Articoli di riviste sul tema "823/.6"
Segui questo link per vedere altri tipi di pubblicazioni sul tema: 823/.6.
Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili
Vedi i top-50 articoli di riviste per l'attività di ricerca sul tema "823/.6".
Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.
Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.
Vedi gli articoli di riviste di molte aree scientifiche e compila una bibliografia corretta.
1
Golosov, O. A., S. S. Khvostov, S. V. Staritsyn, A. V. Barybin, V. I. Pastukhov, N. V. Glushkova, Y. P. Zaikov, E. V. Nikitina e N. A. Kazakovtseva. "EP-823 STEEL CORROSION RATE IN MOLTEN CHLORIDES OF ALKALI METALS". Расплавы, n. 2 (1 marzo 2023): 203–18. http://dx.doi.org/10.31857/s0235010623020068.
Testo completoAbstract (sommario):
At present, technologies are being developed for the regeneration of mixed nitride uranium-plutonium spent nuclear fuel (MNUP SNF) for the BREST-OD-300 reactor plant, including the use of a pyrochemical method of mild chlorination in alkali metal chloride melts to separate fuel from fuel rod claddings made from high radiation resistance of ferritic-martensitic steel EP-823. The paper gives the results of EP-823 static corrosion tests in KCl–LiCl and KCl–LiCl–nPbCl2 molten salts at the temperature of 500 and 650°С during 24 h. Corrosion behaviour of EP-823 steel in non-oxidized and thermal air oxidized state with oxide film thickness up to ~12.5 µm has been investigated using neutron-activation analysis. EP-823 steel samples, irradiated in IVV-2M reactor up to neutron fluence of ~2.9 · 1017 n/cm2, have been examined. It has been shown that corrosion impact of 2KCl–3LiCl and 2KCl–3LiCl–nPbCl2 molten salts on EP-823 element corrosion is selective. It has been established that EP-823 steel in 2KCl–3LiCl molten salts of eutectic composition is highly corrosion-resistant. An increase in the test temperature and the introduction of PbCl2 into the KCl–LiCl salt melt in the amount of one mole percent leads to an increase in the corrosion rate and the removal of steel corrosion products by almost two orders of magnitude. It has been established that oxide films on EP-823 steel surface does not restrain corrosion rate in 2KCl–3LiCl–nPbCl2 molten salts. The values of the constants given in Table 6, make it possible to calculate the values of the average corrosion rates of EP-823 steel and its components (Fe, Cr, Mn) in molten salts 2KCl–3LiCl and 2KCl–LiCl–nPbCl2 at various temperatures.
2
Yuan, Pingchuan, Fang Fang, Taili Shao, Ping Li, Wei Hu, Yuyan Zhou, Guodong Wang, Jun Han e Kaoshan Chen. "Structure and Anti-Tumor Activities of Exopolysaccharides from Alternaria mali Roberts". Molecules 24, n. 7 (5 aprile 2019): 1345. http://dx.doi.org/10.3390/molecules24071345.
Testo completoAbstract (sommario):
In this study, an extracellular polysaccharide from Alternaria mali Roberts (AMEP) was extracted, and its structure was characterized, in addition to its antitumor activity in vitro. Neutral polysaccharide AMEP-1 and anionic polysaccharide AMEP-2 were isolated from AMEP, and their monosaccharide compositions consisted of mannose (Man), glucose (Glc), and galactose (Gal) but at different ratios. The linking mode of both AMEP-1 and AMEP-2 is Manp-(1→4) and Glcp-(1→6), and the branched chains are connected to the main chain through O-6. AMEP-2 inhibited the proliferation of BGC-823 cells in a time- and concentration-dependent manner. AMEP-2 also induced the apoptosis of BGC-823 cells, and showed anti-tumor effects by inducing cell cycle arrest in the S phase, reactive oxygen species production, and mitochondrial membrane potential reduction in BGC-823 cells. Therefore, AMEP-2 shows potential for further development as a novel anti-tumor agent.
3
Yin, Yan-Jiao, Dan-Ling Huang, Bin Qiu, Dan Cai, Jiao-Jiao Zhang, Shao-Xiang Wang, Da-Peng Qin e Yong-Xian Cheng. "Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H". Molecules 25, n. 1 (31 dicembre 2019): 158. http://dx.doi.org/10.3390/molecules25010158.
Testo completoAbstract (sommario):
Five new meroterpenoids, zizhines P-S and U (1−4,7), together with two known meroterpenoids (5 and 6) were isolated from Ganoderma sinensis. Their structures including absolute configurations were assigned by using spectroscopic, computational, and chemical methods. Racemics zizhines P and Q were purified by HPLC on chiral phase. Biological evaluation found that 4, 5 and 6 are cytotoxic toward human cancer cells (A549, BGC-823, Kyse30) with IC50 values in the range of 63.43–80.83 μM towards A549, 59.2 ± 2.73 μM and 64.25 ± 0.37 μM towards BGC-823, 76.28 ± 1.93 μM and 85.42 ± 2.82 μM towards Kyse30.
4
Nath, Jayant, e Paul A. Heidenreich. "823-6 Dilated inferior vena cava: A marker of poor survival". Journal of the American College of Cardiology 43, n. 5 (marzo 2004): A347. http://dx.doi.org/10.1016/s0735-1097(04)91469-6.
Testo completo
5
Holcberg, Gershon, Alaa Amash, Adi Y. Weintraub, Eyal Sheiner, Mahmoud Abu Elhija e Mahmoud Huleihel. "823: Magnesium sulfate downregulates interleukin-6 secretion by preeclamptic human placenta". American Journal of Obstetrics and Gynecology 199, n. 6 (dicembre 2008): S232. http://dx.doi.org/10.1016/j.ajog.2008.09.854.
Testo completo
6
Zygmunt-Kiper, M., L. Blaz e M. Sugamata. "Effect of Temperature on the Structure and Mechanical Properties of Mechanically Alloyed Al-Nio Composite". Archives of Metallurgy and Materials 59, n. 1 (1 marzo 2014): 121–26. http://dx.doi.org/10.2478/amm-2014-0019.
Testo completoAbstract (sommario):
Abstract Mechanical alloying of high-purity aluminum and 10 wt.% NiO powders combined with powder vacuum compression and following hot extrusion method was used to produce an Al-NiO composite. Mechanical properties of as-extruded materials as well as the samples annealed at 823 K /6 h, were tested by compression at 293 K - 770 K. High mechanical properties of the material were attributed to the highly refined structure of the samples. It was found that the structure morphology was practically not changed during hot-compression tests. Therefore, the effect of deformation temperature on the hardness of as-deformed samples was very limited. The annealing of samples at 823 K/6 h induced a chemical reaction between NiO-particles and surrounding aluminum matrix. As a result, the development of very fine aluminum oxide and Al3Ni grains was observed.
7
YE, Qian, Jeong Gyu PARK, Katsutoshi SAWADA, Hiroshi MATSUHISA e Yoshihisa HONDA. "823". Proceedings of Conference of Kansai Branch 2001.76 (2001): _8–51_—_8–52_. http://dx.doi.org/10.1299/jsmekansai.2001.76._8-51_.
Testo completo
8
Chen, Zhou, Dan Hong, Siting Li e Yingmin Jia. "Novel Property Cytotoxicity and Mechanism of Food Preservative Brevilaterins against Human Gastric Cancer Cells". Foods 12, n. 8 (21 aprile 2023): 1732. http://dx.doi.org/10.3390/foods12081732.
Testo completoAbstract (sommario):
Brevilaterins, antimicrobial peptides produced by Brevibacillus laterosporus, are regarded as excellent food preservatives and are popular as antimicrobial applications. Recent research has uncovered their potent cytotoxic effects against diverse cancer cells, thereby underscoring the pressing need for more extensive and intensive investigations into this use. In this study, we explored their novel function in inducing cytotoxicity to cancer cells and systematically investigated the mechanism of action of Brevilaterin B/C (BB/BC) in vivo. Proliferation, membrane permeability, and apoptotic rate were evaluated using CCK-8 assay, LDH assay, and Annexin V-FITC/PI kits. ROS levels and mitochondrial membrane potential were detected using the fluorescent probe DCFH-DA and JC-1. Our results demonstrated that both BB and BC at concentrations of 4–6 µg/mL significantly inhibited the proliferation and migration of gastric cancer cells BGC-823. Treatment with 4 µg/mL of BB/BC rapidly increased LDH levels in the supernatant of BGC-823 cells, leading to further investigation of the mechanism of apoptosis. We found that the apoptotic rate of BGC-823 cells significantly increased upon treatment with BB/BC, demonstrating their potent induction of apoptosis. BB/BC-induced ROS production in BGC-823 cells impaired their growth and induced apoptosis, indicating a close association between apoptosis and ROS elevation. Additionally, JC-1 aggregates rapidly accumulated after treatment with 4 µg/mL of BB/BC, suggesting changes in mitochondrial membrane potential and early apoptosis. Taken together, our findings revealed that BB and BC exhibit significant anticancer effects against gastric cancer cells, highlighting the promising potential of Brevilaterins as anticancer agents.
9
Castrillejo, Y., F. Oduber e E. Barrado. "Evaluation of the thermochemical properties of Ho–Cd intermetallic compounds using electrochemical techniques". RSC Advances 6, n. 75 (2016): 71719–26. http://dx.doi.org/10.1039/c6ra15442e.
Testo completoAbstract (sommario):
The electrochemical formation of HoCd6, HoCd45/11, HoCd3, HoCd2 and HoCd, on a Cd coated tungsten electrode in the eutectic LiCl–KCl has been evaluated using electrochemical techniques over the temperature range of 673–823 K.
10
Zygmunt-Kiper, M., L. Błaz e M. Sugamata. "Effect of Magnesium Addition on Properties of Al-Based Composite Reinforced with Fine NiO Particles". Archives of Metallurgy and Materials 59, n. 2 (1 giugno 2014): 431–35. http://dx.doi.org/10.2478/amm-2014-0071.
Testo completoAbstract (sommario):
Abstract An Al(Mg)-NiO composite was manufactured using combined mechanical alloying (MA) and powder consolidation methods that yielded well-consolidated and very-fine grained bulk material. Compression tests at 293 K - 773 K revealed high mechanical properties of the material. Preliminary annealing at 823 K/6 h was found to result in the flow stress reduction at 573 K - 773 K. However, the effect of preliminary annealing on the flow stress value was relatively low for Al(Mg)-NiO if comparing to similar tests performed for the Al-NiO composite. Structural observations revealed very-fine grained structure of both as-extruded and annealed Al(Mg)-NiO composites. The chemical reaction between the composite matrix and reinforcements (NiO) at sufficiently high temperatures resulted in fine grains and spinel-type particles’ development. With respect to the similarly produced Al-NiO composite, a magnesium addition was found to intensify chemical reaction between Al(Mg)-based matrix and NiO particles. As result, fine Al3Ni particles were observed in both hot-extruded material and Al(Mg)-NiO samples annealed at 823 K/6 h.
11
Tsodyks, Misha, Yeal Adini e Dov Sagi. "Erratum to: Associative learning in early vision [Neural Networks 17 (5–6) 823–832]". Neural Networks 17, n. 10 (dicembre 2004): 1495. http://dx.doi.org/10.1016/j.neunet.2004.09.001.
Testo completo
12
Ke, Chen, Cheng Xiaowen, Wan Yufeng, Li Dongchang, Zhu Huaqing e Wang Zhengguang. "Posttranslational Modifications of Rev-Erbα Protein and Abnormal Inflammatory Response in Gastric Cancer". Journal of Oncology 2022 (28 dicembre 2022): 1–13. http://dx.doi.org/10.1155/2022/6291656.
Testo completoAbstract (sommario):
We reported that Rev-erbα, a transcriptional repressor, is reduced in human gastric cancer and that it inhibits glycolysis in cultured gastric cancer cells. However, it is unclear whether Rev-erbα undergoes posttranslational modifications in gastric cancer. Here, we determined levels of Rev-erbα and its posttranslational modifications including phosphorylation, SUMOylation, and ubiquitination in N-methyl-N-nitrosourea (MNU)/Helicobacter pylori (H. pylori)-induced gastric cancer in mice and in cultured human gastric cancer cells. Administration of MNU plus H. pylori infection successfully induced gastric tumor in C57BL/6J mice. MNU/H. pylori decreased the levels of Rev-erbα in gastric tumor tissues of mice accompanied by an increase in the level of lactic acid. Rev-erbα protein SUMOylation and ubiquitination modifications were significantly increased, whereas phosphorylation was unchanged, in gastric cancer cells line BGC-823 and MNU/H. pylori-induced mouse gastric cancer tissues. Using human gastric cancer tissues, we found that Rev-erbα was specifically reduced in mucosal epithelial cells in gastric tissue. Cytokine levels were increased in MNU/H. pylori-exposed mice compared with control mice. Similarly, the levels of IL-6 IL-10, TNF-α, and VEGF were higher in the BGC-823 cell line compared with GES-1 cells. IL-6 and IL-1 incubation did not affect Rev-erbα levels in BGC-823 cells. Furthermore, Rev-erbα was recruited on the promoters of these cytokine genes, which suppressed their expression. Conclusively, Rev-erbα SUMOylation and subsequent ubiquitination may contribute to its protein reduction, which leads to increased glycolysis and abnormal inflammatory responses during the development of gastric cancer. Targeting Rev-erbα and its SUMOylation represents promising approaches for prevention and management of gastric cancer.
13
Najvar, P., T. Janík e S. Šebestová. "The language of communication in English classrooms in the Czech Republic: Mixing languages". Pedagogická orientace 23, n. 6 (5 febbraio 2014): 823–43. http://dx.doi.org/10.5817/pedor2013-6-823.
Testo completoAbstract (sommario):
Studie se zabývá komunikací ve školní třídě. Konkrétně je zaměřena na používání angličtiny jako cílového jazyka a češtiny jako mateřského jazyka ve výuce angličtiny na základních školách v České republice. Představuje výsledky analýzy 89 vyučovacích hodin anglického jazyka zaměřené na proporci mezi používáním angličtiny a češtiny učiteli a žáky a také na specifické situace, ve kterých jsou oba jazyky míšeny. Analýzy ukázaly, že učitelé ve vyučování vyřkli více českých slov než anglických, zatímco žáci naopak vyřkli více anglických slov než českých. Analýzy využívající časové kódování ukázaly, že angličtina a čeština se ve výuce objevují vyváženě. Alternativní perspektivou na vztah cílového a mateřského jazyka je pohled skrze příležitosti k procvičování jednotlivých jazykových dovedností, jež učitelé ve výuce vytvářejí. V souladu s jinými realizovanými výzkumy byly mezi jednotlivými zkoumanými učiteli pozorovány podstatné rozdíly v tom, do jaké míry využívají ve výuce mateřský jazyk žáků. V závěru studie je představeno pět typických situací, ve kterých ve výuce dochází k míšení jazyků.
14
O' Sullivian, Shaun. "Byzantium and Egypt during the First Arab Civil War". Chronos 25 (23 marzo 2019): 7–31. http://dx.doi.org/10.31377/chr.v25i0.420.
Testo completoAbstract (sommario):
Internal troubles afflicted the Islamic State for the first time in the late 650s and early 660s. Known in Islamic tradition as the firstfitnah, the troubles were described by early Western historians of Islam as what may be termed the 'standard account' of the first Arab civil war. Their account is founded upon the Islamic historical- biographical written tradition, whose corpus ofrecords on the firstfitnah is preserved in the early comprehensive collections of al-Tabari (d.923) and al-Mas'üdi (d.956). But these writers depended on earlier written compilations of oral accounts of the civil war (akhbär), whose authors are listed in al-Nadim's Fihrist, compiled about 987. They include Abü Mikhnaf (d.774), Sayf ibn 'Umar (d. 796), ibn al-Muthannä (d.823-6), al-Wäqidi (d. 823), al-Minqäri (d.827), al-Madä'ini (d.839), ibn Abi Shayba (d.849), and ibn Shabba (d.877). The compilations ofall these authors were grouped around the selected themes of 'Uthmän's murder, the battle of the Camel, and the battle of Siffin with the subsequent arbitration process. Four of the compilations survive.
15
Wang, Hai-Jun, Yu Liu, Bao-Jun Zhou, Zhan-Xue Zhang, Ai-Ying Li, Ran An, Bin Yue, Li-Qiao Fan e Yong Li. "Inhibitory effects of CP on the growth of human gastric adenocarcinoma BGC-823 tumours in nude mice". Journal of International Medical Research 46, n. 5 (23 marzo 2018): 1756–66. http://dx.doi.org/10.1177/0300060518761505.
Testo completoAbstract (sommario):
Objective To investigate the potential antitumour effects of [2-(6-amino-purine-9-yl)-1-hydroxy-phosphine acyl ethyl] phosphonic acid (CP) against gastric adenocarcinoma. Methods Human BGC-823 xenotransplants were established in nude mice. Animals were randomly divided into control and CP groups, which were administered NaHCO3 vehicle alone or CP dissolved in NaHCO3 (200 µg/kg body weight) daily, respectively. Tumour volume was measured weekly for 6 weeks. Resected tumours were assayed for proliferative activity with anti-Ki-67 or anti-proliferating cell nuclear antigen (PCNA) antibodies. Cell apoptosis was examined using terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) assays and with caspase-3 immunostaining. Proteins were measured by Western blotting. Results There was a significant reduction in tumour volume and a reduced percentage of Ki-67-positive or PCNA-positive cells in the CP group compared with the control group. The percentage of TUNEL-positive or caspase 3-positive cells significantly increased following CP treatment compared with the control group. Tumours from the CP group had higher levels of phosphorylated-extracellular signal-regulated kinase (p-ERK) and phosphorylated-AKT (p-AKT) compared with control tumours. Conclusion CP treatment inhibited tumour growth and induced tumour cell apoptosis in a nude mouse model of BGC-823 gastric adenocarcinoma. Activation of the AKT and ERK signalling pathways may mediate this antitumour activity.
16
Belomyttsev, M. Yu, e V. G. Molyarov. "CREEP RESISTANCE OF FERRITIC-MARTENSITIC STEEL 16Cr12MoWSiVNbB (EP-823)". Izvestiya. Ferrous Metallurgy 62, n. 4 (20 giugno 2019): 290–302. http://dx.doi.org/10.17073/0368-0797-2019-4-290-302.
Testo completoAbstract (sommario):
Base characteristics of ferritic-martensitic heat resisting steels with 12 % of chrome are parameters of their strength and creep resistance at temperatures of 600 – 750 °С. Steel 16Cr12MoWSiVNbB (EP-823) is considered as the basic material for manufacturing environments fuel rods (TVEL) of a developed reactor with natural safety of BRESTtype. In the literature, there are data about its mechanical characteristics for tensile tests in a range of temperatures of 20 – 750 °С and the limited characteristics of rupture strength. Data on its creep velocity is absent. Laws of creep of steel EP-823 were investigated on metal of three heats with weight of 3 kg. The compression tests at air were applied for cylindrical samples of 5 ÷ 6 mmat temperatures of 600 – 760 °С and stresses of 70 – 310 MPa. The base of compression tests did not exceed 11 hours. The structure after quenching and tempering consisted of tempered martensite and 6 – 12 vol. % of delta-ferrite, the grain size was less 20 μm. It is shown, that the description of creep tests results in double logarithmic (log (σ) – log (έ)) coordinates provides the best concurrence of results of approximation and experiment, than in half-logarithmic (σ – log (έ)). The analysis of parametrical dependences on Hollomon’s PS = (T/1000)[CS – log (έ) and to Larsen-Miller’s PE = (T/1000)[СE – log (σ)] has allowed to find the equations for creep velocity for the set pressure level of 100 – 220 MPa in the form of log (έ) = –19,355 + 9,17 (T/1000) log (σ) and ultimate strength of creep under the set admissions for creep velocity of 0,01 – 1 %/hour in the form of log (σ) = 4,304 – – 0,109 (T/1000) [20 – log (έ)]. Calculations of ultimate strength of creep and creep velocity on pair models and models of Hollomon (Larsen-Miller) give close results, but the preference should be given the second ones as these models consider all three varied factors. Data of control tests under the scheme of a tensile in the same conditions are cited. It is shown, that between results of tests on compression and on tensile at definition of durability characteristics, there is the linear dependence expressed by the equation σ0.2 at compression = 1.3σ0.2 at tensile. At the analysis of creep it has been established, that creep velocity for steel of one grade (09Cr12W3NbB) and for one heat at different type of loading (tensile or compression) have similar values while creep velocities for steel of one grade (EP-823), but of different heats even at one type of loading – compression, can differ substantially.
17
Yakufu, Mirensha, Renaguli Hailiwu, Yuanyuan Cong, Ayijiang Habaike, Xiaomei Wang e Palida Abulizi. "Antitumor activity of flavonoids from Alpinia officinarum hance on gastric cancer". European Journal of Inflammation 19 (gennaio 2021): 205873922110511. http://dx.doi.org/10.1177/20587392211051119.
Testo completoAbstract (sommario):
Introduction: To investigate antitumor activity and mechanism of flavonoids from Alpinia officinarum Hance against gastric cancer. Methods: Transplanted mouse fore-stomach carcinoma (MFC) tumor mice were divided into six groups: control group, model group, low dose (20 mg/kg), middle dose (40 mg/kg), and high dose (80 mg/kg) groups of TFAO and 5-Fu group. Mice were treated with TFAO or 5-Fu for 14 days, except those of control and model group. Tumor inhibitory rate, spleen, and thymus index were calculated. Contents of proliferating cell nuclear antigen, MMP-9, vascular endothelial growth factor, IL-1β, IL-6, and IL-17 in serum were detected. Effect of galangin on BGC-823 cell growth was detected. Cell apoptosis and cell cycle distribution were measured. Enzyme activity of Caspase-3, Caspase-8, and Caspase-9 was detected. Western blot was used to detect STAT3, Bcl-2, Bax, Caspase-3, Caspase-8, Caspase-9, CyclinB1, and CyclinD1 protein expression in BGC-823 cell. Results: Compared with model group, tumor weight of mice decreased significantly ( p < .01) in 5-Fu group, low dose, middle dose, and high dose group of TFAO; thymus index of mice decreased significantly ( p < .05) in 5-Fu group; and spleen index decreased significantly ( p < .05) in low dose and middle dose groups of TFAO. Compared with model group, levels of PCNA, MMP-9, IL-1β, and IL-6 in serum of mice decreased obviously ( p < .01) in all administration groups; levels of VEGF in serum of mice decreased obviously ( p < .01) in low dose and high dose group of TFAO and 5-Fu group; and levels of IL-17 in serum of mice decreased significantly ( p < .01) in low-dose and middle-dose groups of TFAO and 5-Fu group. Galangin could inhibit BGC-823 cell growth; accelerate apoptosis; block cell cycle; increase cell Caspase-3, Caspase-8, and Caspase-9 enzyme activity; upregulate expression of Caspase-3, Caspase-8, Caspase-9, and Bax; and downregulate expression of STAT3, CyclinB1, CyclinD1, and Bcl-2 protein. Conclusion: Flavonoids from A. officinarum showed antitumor activity in gastric cancer. Mechanisms may be associated with inhibition of tumor angiogenesis, tumor cell proliferation, and cancer-associated inflammation.
18
Guo, Xiao, LiPing An, RunHong Mu, YuPeng Li, JiaYing Xing, YanDong Li, Rui Lin, SiPing Ye, YaoYue Zhang e Han Mu. "Effect of lentivirus-mediated peroxiredoxins 6 gene silencing on the phenotype of human gastric cancer BGC-823 cells". Journal of Cancer Research and Therapeutics 18, n. 2 (2022): 411. http://dx.doi.org/10.4103/jcrt.jcrt_1083_21.
Testo completo
19
Eftifeeva, Anna S., Elena Y. Panchenko, Ilya D. Fatkullin, Mikhail N. Volochaev, Anton I. Tagiltsev e Yuriy I. Chumlyakov. "The Cyclic Stability of Superelasticity in Aged Ti49.3Ni50.7 Single Crystals with Oxide Surface". Metals 12, n. 12 (8 dicembre 2022): 2113. http://dx.doi.org/10.3390/met12122113.
Testo completoAbstract (sommario):
The cyclic stability of superelasticity in compression in [001]B2-oriented Ti49.3Ni50.7 single crystals is considered in this paper. The crystals were aged at 823 K for 1.0 h in air and helium. It has been experimentally shown that a two-layered surface thin film, consisting of a Ni-free oxide layer and a Ni-rich sublayer, appears after the oxidation at 823 K in air. The surface layers have a weak effect on the forward B2-R-B19’ martensitic transformation temperatures: TR temperature increases by 4 K; Ms and Mf temperatures decrease by 6 K. The oxide layer does not affect either the superelasticity response during fatigue tests or the temperatures of reverse B19’-B2 martensitic transformation. The cracking of the surface oxide layer during fatigue tests was not found in [001]B2-oriented single crystals aged in air. This is contributed by the relaxation of internal stresses. Such internal stresses are caused by both the formation of an oxide layer during aging and the matrix deformation at the stress-induced martensitic transformation. The main relaxation mechanisms of the internal stresses are the oriented growth of Ti3Ni4 precipitation near a thin surface film at aging in air, the formation of dislocations near the precipitation-matrix interface and a fine twinned B19’-martensite at fatigue tests.
20
Zhang, Jing, Xin-Ling Fu, Nan Yang e Qiu-An Wang. "Synthesis and Cytotoxicity of Chalcones and 5-Deoxyflavonoids". Scientific World Journal 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/649485.
Testo completoAbstract (sommario):
Chalcones1~8and 5-deoxyflavonoids9~22were synthesized in good yields by aldol condensation, Algar-Flynn-Oyamada reaction, glycosidation, and deacetylation reaction, respectively, starting from 2-acetyl phenols substituted by methoxy or methoxymethoxy group and appropriately benzaldehydes substituted by methoxy, methoxymethoxy group, or chlorine. Among them,13and17~22are new compounds. The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds2, 4, 5, 6, 10, 15, and19exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).
21
Norikawa, Yutaro, Kouji Yasuda e Toshiyuki Nohira. "Effect of Temperature on Grain Growth during Ti Electrodeposition in Lif–LiCl Eutectic Melt". ECS Meeting Abstracts MA2022-01, n. 23 (7 luglio 2022): 1197. http://dx.doi.org/10.1149/ma2022-01231197mtgabs.
Testo completoAbstract (sommario):
1. Introduction Ti has superior properties, such as high specific strength, corrosion resistance, biocompatibility, and is used for many fields such as airplane, chemical plant, consumer products. However, its high manufacturing cost and poor processability have hindered its further spread. Thus, a number of smelting processes and processing methods have been investigated to reduce the cost and spread the use of Ti. Among them, plating Ti metal on inexpensive substrates is one of the methods that can utilize the surface properties of Ti. Electrodeposition is a promising plating method from the viewpoints of the cost and the flexibility in shape of substrate. Therefore, electrodeposition of Ti metal in high-temperature molten salts has been investigated for a long time [1–3]. Our group has reported the electrodeposition of Ti films with compact and smooth surfaces in molten KF–KCl and LiF–LiCl containing Ti(III) ions at 923 K [4–7]. We also reported that the Ti films obtained in LiF–LiCl at 823 K had smoother surfaces [8]. In the present study, we investigated the effect of temperature on the grain growth and smoothness of Ti films electrodeposited in LiF–LiCl eutectic melt at 823–973 K. 2. Experimental The experiments were carried out in eutectic LiF–LiCl melt (30:70 mol%, melting point 774 K) at 823–973 K. The melt was placed in a nickel crucible and the experiments were conducted in an airtight Kanthal container in an argon glove box. As Ti(III) ion sources, Li2TiF6 (2.00 mol%) and Ti sponge (1.33 mol%) were added to the melt. The added amounts of Ti sponge were twice the amounts necessary to generate Ti(III) ions by comproportionation reaction between Ti(IV) ions and Ti(0) according to Eq. 1. Ti(0) + 3Ti(IV) → 4Ti(III) (1) Ni plates were used as working electrodes, and Ti rods was used as counter and reference electrodes. The samples prepared by galvanostatic electrolysis were analyzed by XRD and SEM/EDX after washing with distilled water to remove adhered salts. 3. Results and Discussion Fig. 1 shows the optical and surface SEM images of the samples obtained by galvanostatic electrolysis at 823, 873, 923, and 973 K. The cathodic current density was 50 mA cm−2 and electrolysis time was 20 min. All the samples have a metallic luster and are confirmed to be Ti metal by XRD analysis. However, the brightness differs between samples, with the Ti film at 823 K showing the highest brightness. From the surface SEM images, the crystal grain size of Ti increases as the temperature rises. This tendency is reasonably explained by previous work on the temperature dependence on grain growth of Ti [9]. Also, the value of surface roughness (Sa) measured by SEM increases as the temperature increases. The smoothest Ti film with Sa = 2.05 ± 0.22 μm was obtained at 823 K. These results show that Ti film with smoother surface can be electrodeposited by suppressing the grain growth of Ti at lower temperatures. To obtain thicker films, electrolysis was conducted for longer time at 823 K, where grain growth is suppressed. Fig. 2 shows the optical and SEM images of the samples obtained by galvanostatic electrolysis at a cathodic current density of 50 mA cm−2 and charge densities of 60, 150, and 450 C cm−2. As shown in the SEM images, the thickness of the Ti film increases with the increase in charge density. Although some deposition onto the edge was observed at 450 C cm−2, the thickness of the Ti film reaches 100 μm. Acknowledgement A part of this work was supported by JSPS Fellows grant number 19J15015. A part of this study was conducted as a collaboration with Sumitomo Electric Industries, Ltd. The present address of Kouji Yasuda is Graduate School of Engineering, Kyoto Univ. References [1] D. Wei, M. Okido, and T. Oki, J. Appl. Electrochem., 24, 923 (1994). [2] A. Robin and R. B. Ribeiro, J. Appl. Electrochem., 30, 239 (2000). [3] V. V. Malyshev and D. B. Shakhnin, Mater. Sci., 50, 80 (2014) [4] Y. Norikawa, K. Yasuda, and T. Nohira, Mater. Trans., 58, 390 (2017). [5] Y. Norikawa, K. Yasuda, and T. Nohira, Electrochemistry, 86, 99 (2018). [6] Y. Norikawa, K. Yasuda, and T. Nohira, J. Electrochem. Soc., 166, D755 (2019). [7] Y. Norikawa, K. Yasuda, and T. Nohira, J. Electrochem. Soc., 167, 082502 (2020). [8] M. Unoki, Y. Norikawa, K. Yasuda, and T. Nohira, ECS Trans., 98, 393 (2020) [9] K. Okazaki and H. Conrad, Metall. Trans., 3, 2411 (1972). Figure 1
22
Gómez-Vargas, O. A., M. Ortiz-Domínguez, I. Campos-Silva, U. Figueroa-López, J. Oseguera-Peña, J. A. García-Macedo, V. A. Castellanos-Escamilla et al. "Formación de una capa boronitrurada en un hierro puro ARMCO". Tópicos de Investigación en Ciencias de la Tierra y Materiales 2, n. 2 (1 settembre 2015): 209–19. http://dx.doi.org/10.29057/aactm.v2i2.9872.
Testo completoAbstract (sommario):
El presente trabajo estudia un proceso de endurecimiento superficial a través de la formación de una capa boronitrurada sobre la superficie de un hierro puro. La selección del hierro puro es para evadir la influencia de algún elemento de aleación que modifique el crecimiento de las capas. Los procesos fueron llevados a cabo de acuerdo a la siguiente secuencia: Para el proceso de borurización de pasta se sometieron diferentes muestras a temperaturas de 1173, 1223 y 1273 K con tiempos de 4, 6 y 8 horas para cada temperatura. Posteriormente, para el proceso de nitrurado empleando la técnica de empaquetamiento en caja se utilizaron temperaturas de 823 y 843K con tiempos de 4 y 6 horas. Las capas obtenidas fueron caracterizadas por microscopia óptica, microscopía electrónica de barrido, análisis por EDS así como evaluación por microdureza.
23
Dekemper, E., F. Vanhellemont, N. Mateshvili, G. Franssens, D. Pieroux, C. Bingen, C. Robert e D. Fussen. "Zernike polynomials applied to apparent solar disk flattening for pressure profile retrievals". Atmospheric Measurement Techniques 6, n. 3 (27 marzo 2013): 823–35. http://dx.doi.org/10.5194/amt-6-823-2013.
Testo completoAbstract (sommario):
Abstract. We present a passive method for the retrieval of atmospheric pressure profiles based on the measurement of the apparent flattening of the solar disk as observed through the atmosphere by a spaceborne imager. This method was applied to simulated sunsets. It relies on accurate representation of the solar disk, including its limb darkening, and how its image is affected by atmospheric refraction. The Zernike polynomials are used to quantify the flattening in the Sun images. The inversion algorithm relies on a transfer matrix providing the link between the atmospheric pressure profile and a sequence of Zernike moments computed on the sunset frames. The transfer matrix is determined by a training dataset of pressure profiles generated from a standard climatology. The performance and limitations of the method are assessed by two test cases. Pressure profiles similar to the training dataset show that retrieval error can be up to 10 times smaller than the natural variability in the lower mesosphere, and up to 500 times smaller in the upper troposphere. Tests with other independent profiles emphasize the need for better representativeness of the training dataset.
24
Rodrigo Comino, J., C. Brings, T. Lassu, T. Iserloh, J. M. Senciales, J. F. Martínez Murillo, J. D. Ruiz Sinoga, M. Seeger e J. B. Ries. "Rainfall and human activity impacts on soil losses and rill erosion in vineyards (Ruwer Valley, Germany)". Solid Earth 6, n. 3 (9 luglio 2015): 823–37. http://dx.doi.org/10.5194/se-6-823-2015.
Testo completoAbstract (sommario):
Abstract. Vineyards are one of the eco-geomorphological systems most conditioned by human activity in Germany. The vineyards of the Ruwer Valley (Germany) are characterized by high soil erosion rates and rill problems on steep slopes (between 23 and 26°) caused by the increasingly frequent heavy rainfall events as well as deterioration due to incorrect land use managements. The objective of this paper is to determine and to quantify the hydrological and erosive phenomena in one vineyard in Germany during different seasons and under different management conditions (before, during and after vintage). For this purpose, a combined methodology was applied. Climatic (rainfall depth distributions and return periods), pedological (soil analysis and classification), geomorphological (sediment movements and rills evolution) and biological (botanic marks on the vines) variables were used on the two experimental plots in the village of Waldrach (Trier, region of Rhineland-Palatinate). The results showed high infiltration rates (near 100 %) and subsurface flow which were detected by rainfall simulations performed at different times of the year (between September and December). The highest variations of the monitored rills (lateral and frontal movements) were noted before and during vintage, when footsteps occurred concentrated during a short period of time (between September and October). Finally, two maps of soil loss were generated, indicated by botanic marks on the graft union of the vines. 62.5 t ha−1 yr−1 soil loss was registered in the experimental plots of the new vineyards (2 years), while 3.4 t ha−1 yr−1 was recorded in the old one (35 years).
25
Valentine, B. A., e B. J. Cooper. "Incidence of Polysaccharide Storage Myopathy: Necropsy Study of 225 Horses". Veterinary Pathology 42, n. 6 (novembre 2005): 823–27. http://dx.doi.org/10.1354/vp.42-6-823.
Testo completoAbstract (sommario):
Muscle samples were obtained at necropsy from 225 horses and ponies 1 year of age or older. Samples were processed in routine manner and were stained with hematoxylin and eosin and with periodic acid-Schiff for glycogen. Sections were examined for abnormal glycogen content and amylase- resistant complex polysaccharide and for chronic myopathic change (excessive fiber size variation, increase in number of internal nuclei). A total of 101 horses and ponies with lesions of polysaccharide storage myopathy were identified. Age of affected horses ranged from one to 30 years, with a mean of 14.7 years. Mean age of nonaffected horses was 12 years. Incidence of polysaccharide storage myopathy varied depending on breed; Thoroughbreds had the lowest (27%) and draft-related horses had the highest (86%) incidence. Chronic myopathic changes were more severe in polysaccharide storage myopathy-affected horses than in nonaffected horses. Results of this study indicate that polysaccharide storage myopathy is a common disorder of many breeds of horses and ponies.
26
Al-Dissi, A. N., D. M. Haines, B. Singh e B. A. Kidney. "Immunohistochemical Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Associated with Tumor Cell Proliferation in Canine Cutaneous Squamous Cell Carcinomas and Trichoepitheliomas". Veterinary Pathology 44, n. 6 (novembre 2007): 823–30. http://dx.doi.org/10.1354/vp.44-6-823.
Testo completo
27
Cheng, Kuo-Chi, Perrin C. White e Ke-Nan Qin. "Molecular Cloning and Expression of Rat Liver 3α-Hydroxysteroid Dehydrogenase". Molecular Endocrinology 5, n. 6 (giugno 1991): 823–28. http://dx.doi.org/10.1210/mend-5-6-823.
Testo completo
28
Jia, Tai Xuan, Ji Chang Zhang e Zi Li Liu. "Preparation and Property of Y-Mg-Al-Layered Double Oxides". Advanced Materials Research 396-398 (novembre 2011): 764–67. http://dx.doi.org/10.4028/www.scientific.net/amr.396-398.764.
Testo completoAbstract (sommario):
Y-Mg-Al-layered double Oxides (Y-Mg-Al-LDO) were prepared by calcining Y3+-doped Mg-Al-layered hydrotalcites at 823 K for 8 h from co-precipitation method. The samples were detected by XRD and CO2-TPD. Micro-structure and essential regularity were disclosed. The acetone condensation reaction as a probe reaction was carried on fixed-bed micro-reactor at reactive temperature 673 K, reactive time 3 h and liquid hourly space velocity (LHSV) 6 h-1 over Y-Mg-Al-LDO. The catalyst evaluation results show that Y-Mg-Al-LDO possess high catalytic activity. The maximum value of acetone conversion reached 37.53%. The selectivity and single-pass-yield of isophorone were 55.66% and 20.89%, respectively.
29
Singh, D. K., C. S. P. Singh e H. R. Mishra. "Genetic and non-genetic factors affecting post-weaning survivability in goats". Animal Science 53, n. 2 (ottobre 1991): 199–202. http://dx.doi.org/10.1017/s0003356100020122.
Testo completoAbstract (sommario):
AbstractGenetic and non-genetic factors affecting survival during the post-weaning period from 3 to 12 months of age were assessed in 823 kids (217 Black Bengal, 410 Jamunapari × Black Bengal and 196 Beetal × Black Bengal) born during 1981-86. The overall survival rates during 3 to 6 and 6 to 12 months of age were 79·22 (s.e. 4·06) and 82·02 (s.e. 5·49)% respectively. Variation in survival rate during 3 to 6 months of age was significant due to season of their birth (P < 0·01) and birth weight (P < 0·05). Survival rate during 6 to 12 months of age varied due to genetic group (P < 0·01), sex (P < 0·05) and birth weight (P < 0·05). Type of birth (litter size), dam's weight at kidding and filial generation had no significant effect on survival rate during the post-weaning period. Birth weight of kids had a positive linear relationship with their survivability during post-weaning period. Summer-born kids had significantly lower survival rates from 3 to 6 months of age compared with those born in the winter and monsoon periods. Heritability estimates for survival rates during the post-weaning period were not significantly different from zero.
30
Naydenkin, E. V., e I. P. Mishin. "Evolution of the structure and grain boundary ensemble of nickel during diffusion annealing under conditions of a segregating impurity (silver) along grain boundaries". Izvestiya vysshikh uchebnykh zavedenii. Fizika, n. 7 (2021): 30–35. http://dx.doi.org/10.17223/00213411/64/7/30.
Testo completoAbstract (sommario):
Investigations of the effect of an impurity (silver) segregating along the grain boundaries of nickel on the evolution of the structure and grain-boundary ensemble under conditions of diffusion annealing at a temperature of 823 K for 6 hours have been carried out. It is shown that, under these conditions, the development of a diffusion-induced recrystallization (DIR) process is observed in the Ni(Ag) system, in contrast to the Ni(Cu) system, in which the process of diffusion-induced grain boundary migration (DIGM) was observed. The estimates made have shown that a possible reason for the fact that diffusion-induced migration of grain boundaries practically does not occur in the Ni(Ag) system can be significantly lower than in the Ni(Cu) system the value of osmotic pressure as the driving force for the DIGM process.
31
Verhoeven, J. W. "The Chemistry of Enols. Zvi Rappoport, ed. John Wiley & Sons, Chichester, 1990. XVI + 823 pp., £195.00. ISBN 0-471-91720-6". Recueil des Travaux Chimiques des Pays-Bas 110, n. 9 (2 settembre 2010): 389. http://dx.doi.org/10.1002/recl.19911100908.
Testo completo
32
Petukhov, Nikolai, Ekaterina Ryabtseva, Yuri Tuganov e Vladimir Aulov. "Preventing Corruption in the Judicial System of the Russian Federation: Opportunities for Corruption Connected with the Discretionary Powers of the Court Chairperson". Russian Journal of Criminology 14, n. 6 (30 dicembre 2020): 823–33. http://dx.doi.org/10.17150/2500-4255.2020.14(6).823-833.
Testo completoAbstract (sommario):
At the present moment, corruption crimes committed by civil service employees not only interfere with the work of public officials endowed with authority, but they also undermine the credibility of state power, the trust and respect of people for state institutions and, primarily, for equitable justice. The article describes the experience of counteracting corruption in the practice of courts and judicial bodies, including the High Qualification Board of Judges, the Councils of Judges of the Russian Federation and of its regions. Adhering to the requirements of international law and taking into consideration the national law systems, the authors based their research on the inter-disciplinary systemic approach, which is necessary for the effective prevention of corruption in the court system. The theoretical results of the research were reflected in determining both the general regularities of combating corruption in the court system and the specific characteristics that take into consideration the structural and functional features of court power and the legal status of public officials. The practical results include suggestions on optimizing the organization of corruption prevention in the court system, the cooperation of courts and judicial bodies with other state bodies and public institutions on counteracting corruption while preserving the independence of the judicial power. The practical conclusions could be used for optimizing the work of courts and judicial bodies connected with the organization and implementation of anti-corruption measures.
33
MARANTZ, PAUL R. "Inability to Predict Diagnosis in Febrile Intravenous Drug Abusers". Annals of Internal Medicine 106, n. 6 (1 giugno 1987): 823. http://dx.doi.org/10.7326/0003-4819-106-6-823.
Testo completo
34
Ramirez, Ramses M., e Lisa Kaltenegger. "HABITABLE ZONES OF POST-MAIN SEQUENCE STARS". Astrophysical Journal 823, n. 1 (16 maggio 2016): 6. http://dx.doi.org/10.3847/0004-637x/823/1/6.
Testo completo
35
XianYu, Zheng-Nan, e An Du. "Magnetic Properties of XXZ Heisenberg Antiferromagnetic and Ferrimagnetic Nanotubes". Communications in Theoretical Physics 70, n. 6 (dicembre 2018): 823. http://dx.doi.org/10.1088/0253-6102/70/6/823.
Testo completo
36
Messier, Stephen P., Daniel P. Beavers, Kate Queen, Shannon L. Mihalko, Gary D. Miller, Elena Losina, Jeffrey N. Katz et al. "Effect of Diet and Exercise on Knee Pain in Patients With Osteoarthritis and Overweight or Obesity". JAMA 328, n. 22 (13 dicembre 2022): 2242. http://dx.doi.org/10.1001/jama.2022.21893.
Testo completoAbstract (sommario):
ImportanceSome weight loss and exercise programs that have been successful in academic center–based trials have not been evaluated in community settings.ObjectiveTo determine whether adaptation of a diet and exercise intervention to community settings resulted in a statistically significant reduction in pain, compared with an attention control group, at 18-month follow-up.Design, Setting, and ParticipantsAssessor-blinded randomized clinical trial conducted in community settings in urban and rural counties in North Carolina. Patients were men and women aged 50 years or older with knee osteoarthritis and overweight or obesity (body mass index ≥27). Enrollment (N = 823) occurred between May 2016 and August 2019, with follow-up ending in April 2021.InterventionsPatients were randomly assigned to either a diet and exercise intervention (n = 414) or an attention control (n = 409) group for 18 months.Main Outcomes and MeasuresThe primary outcome was the between-group difference in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) knee pain score (range, 0 [none] to 20 [severe]; minimum clinically important difference, 1.6) over 18 months, tested using a repeated-measures mixed linear model with adjustments for covariates. There were 7 secondary outcomes including body weight.ResultsAmong the 823 randomized patients (mean age, 64.6 years; 637 [77%] women), 658 (80%) completed the trial. At 18-month follow-up, the adjusted mean WOMAC pain score was 5.0 in the diet and exercise group (n = 329) compared with 5.5 in the attention control group (n = 316) (adjusted difference, −0.6; 95% CI, −1.0 to −0.1; P = .02). Of 7 secondary outcomes, 5 were significantly better in the intervention group compared with control. The mean change in unadjusted 18-month body weight for patients with available data was −7.7 kg (8%) in the diet and exercise group (n = 289) and −1.7 kg (2%) in the attention control group (n = 273) (mean difference, −6.0 kg; 95% CI, −7.3 kg to −4.7 kg). There were 169 serious adverse events; none were definitely related to the study. There were 729 adverse events; 32 (4%) were definitely related to the study, including 10 body injuries (9 in diet and exercise; 1 in attention control), 7 muscle strains (6 in diet and exercise; 1 in attention control), and 6 trip/fall events (all 6 in diet and exercise).Conclusions and RelevanceAmong patients with knee osteoarthritis and overweight or obesity, diet and exercise compared with an attention control led to a statistically significant but small difference in knee pain over 18 months. The magnitude of the difference in pain between groups is of uncertain clinical importance.Trial RegistrationClinicalTrials.gov Identifier: NCT02577549
37
Johnson, Anne Marie, e Ted Whitwell. "Selecting Species to Produce Wildflower Seeds". HortTechnology 7, n. 4 (ottobre 1997): 415–17. http://dx.doi.org/10.21273/horttech.7.4.415.
Testo completoAbstract (sommario):
Twenty-nine annual and perennial wildflower species were evaluated for commercial seed production potential in South Carolina. Species selection was based on adaptability to southeastern conditions and potential for use in wildflower sod. Potential for seed production was based on seed maturation ratings, percent germination 4 to 6 weeks after harvest, and yield. Individual species were seeded into I-m2 plots (3.3 ft2), on 7 Oct. Seeds were collected, clcaned, and counted, and total seed yield (lb) was calculated based on seed germination and weight of 100 seeds. Species with potential for production were Hesperis matronalis L. (2605 lb/acre), Monarda citriodora Cer. ex Lag. (1247 lb/A), Silene armeria L. (1122 lb/acre), Bidens aristosa (Michaux) Britton. (41 lb/acre), Centaurea cyanus L. (823 lb/acre), Coreopsis tinctoria Nutall (185 lb/acre), Gypsophila elegans L. (120 lb/acre), Ipomopsis rubra (L.) (2301 lb/acre) Wherry, and Rudbeckia hirta L. (500 lb/acre).
38
He, Wen Jun, Zhao Hui Fu, Hong Jin Han, He Yan, Guang Zhi Zeng, Chang Jiu Ji, Hong Biao Chu, Yu Mei Zhang e Ning Hua Tan. "Benzoic Acid Allopyranosides and Lignan Glycosides from the Twigs of Keteleeria evelyniana". Zeitschrift für Naturforschung B 66, n. 7 (1 luglio 2011): 733–39. http://dx.doi.org/10.1515/znb-2011-0715.
Testo completoAbstract (sommario):
Seven new compounds, including three benzoic acid allopyranosides keteleeroside A (1), keteleeroside B (2) and keteleeroside C (3), and four lignan glycosides 3’-demethylicariside E3 (4), isocupressoside B (5), 3-methoxyisocupressoside B (6), and isomassonianoside B (7), along with five known compounds (8 - 12), were isolated from the n-butanol part of the methanolic extract of the twigs of Keteleeria evelyniana. The structures of these compounds were elucidated mainly by the analysis of their NMR and MS data. All compounds were isolated from this genus for the first time. The skeleton of lignan glycoside 4 was isolated from the Pinaceae family for the first time. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and their cytotoxic activity against K562, HT-29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines was studied. Results indicated that none of the compounds showed antimicrobial or cytotoxic activity.
39
Berrada, N., R. Conforti, S. Delaloge, M. Spielmann e F. Andre. "Use of molecular classification combined with p53 and topoisomerase IIa expression to identify tumors highly responsive to FEC regimen: A tissue microarray". Journal of Clinical Oncology 27, n. 15_suppl (20 maggio 2009): 546. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.546.
Testo completoAbstract (sommario):
546 Background: Identification of highly responsive tumors to specific regimen is needed in order to better tailor post-operative chemotherapy regimen. We previously reported using a tissue microarrays that basal-like and HER2-overexpressing tumors derive higher benefit from adjuvant chemotherapy than luminal-like tumors. Previous studies have reported that p53+/basal-like tumors, and HER2+/topoisomerase IIa + tumors were highly sensitive to alkylating agents and anthracyclines respectively. In the present study, we have evaluated whether p53+/basal-like and HER2+TopIIa+ tumors derive high benefit from an alkylating/anthracyclines based chemotherapy. Methods: A tissue microarrays was built with tumor samples from 823 patients randomized between FEC/FAC regimen and no chemotherapy. Basal-like breast cancers were defined as HER2-/ER-/EGFR+ and/or CK5/6+ tumors. HER2-overexpressing were defined using HER2 expression by IHC (3+ score). P53 and topoisomerase IIa expression were assessed by IHC. Treatment effect was assessed by Cox model that included prognostic parameters and stratification variables. Predictive value for treatment effect were assessed by interaction test and test for heterogeneity. Results: 823 patients were included. 12.5% and 12.9% patients presented a basal-like and HER2-overexpressing breast cancer respectively. P53 and topoisomerase IIa were expressed in 20% and 35% patients. Hazard ratio for relapse associated with FEC/FAC regimen was 0.79 (95%CI: 0.62–1). Hazard ratio associated with FEC/FAC were 0.31 (0.1–0.97 ) and 1.19 (0.38–3.7 ) in patients with p53+/basal-like and p53- basal-like breast cancer. A p53/basal-based classification was associated with a trend for heterogeneity (p = 0.15). Hazard ratio associated with FEC/FAC were 0.34 (0.11–1.0 ) and 1.27(0.32–4.9) in patients with topIIa+/HER2+ and topIIa-/HER2+ breast cancer. A HER2/TopIIa classification was associated with a trend for heterogeneity (p = 0.07). Conclusions: The present study suggest that p53+/basal-like cancer and TopIIA+/HER2 cancers derive high benefit from adjuvant FEC/FAC regimen. This finding requires further validation given multihypothesis testing and subgroup analysis. No significant financial relationships to disclose.
40
Gaisenok, O. V. "THE USE OF AMIODARONE IN CLINICAL PRACTICE: THE PROBLEM OF SIDE EFFECTS". Rational Pharmacotherapy in Cardiology 6, n. 6 (1 gennaio 2010): 823–27. http://dx.doi.org/10.20996/1819-6446-2010-6-6-823-827.
Testo completo
41
Liu, Zhang, Wu, Chen, Li, Dai e Wang. "Four New ent-Kaurane Diterpene Glycosides from Isodon henryi". Molecules 24, n. 15 (27 luglio 2019): 2736. http://dx.doi.org/10.3390/molecules24152736.
Testo completoAbstract (sommario):
To obtain diterpene glycosides from an aqueous extract of the aerial parts of Isodon henryi and further investigate their cytotoxicities, in this study, a total of seven compounds were isolated, including six ent-kaurane diterpene glycosides (1–6) and one diterpene aglycon (7). Among the seven ent-kaurane diterpenes obtained, four were novel compounds, including ent-7,20-epoxy- kaur-16-en-1α,6β,7β,15β-tetrahydroxyl-11-O-β-d-glucopyranoside (1), ent-7,20-epoxy-kaur-16-en- 6β,7β,14β,15β-tetrahydroxyl-1-O-β-d-glucopyranoside (2), ent-7,20-epoxy-kaur-16-en-6β,7β,15β- trihydroxyl-1-O-β-d-glucopyranoside (3), and ent-7,20-epoxy-kaur-16-en-7β,11β,14α,15β-tetrahydr- oxyl-6-O-β-d-glucopyranoside (4), and three were isolated from this plant for the first time (5–7). Their structures were elucidated by utilizing spectroscopic methods and electronic circular dichroism analyses. Furthermore, the cytotoxicities of all seven compounds were investigated in four human cancer cell lines, including A2780, BGC-823, HCT-116, and HepG2. The IC50 values of these diterpenes ranged from 0.18 to 2.44 mM in the tested cell lines. In addition, the structure–cytotoxicity relationship of diterpene glycosides was also evaluated to study the effect of glycosylation on the cytotoxicity of diterpene compounds.
42
Schy, Debbie, Nathaniel Leonardi, Sarah E. Kozmic, Jeanne Wiesbrock e Suela Sulo. "Pumping Practices and Characteristics of Mothers With Preterm Babies Going to the Neonatal Intensive Care Unit". Clinical Lactation 8, n. 2 (2017): 66–73. http://dx.doi.org/10.1891/2158-0782.8.2.66.
Testo completoAbstract (sommario):
Introduction: The benefits of mothers own milk on premature and ill infants’ nutritional, immunological, and developmental needs have been shown. This article aims to provide insights regarding pumping practices and characteristics of mothers with preterm babies in the neonatal intensive care unit (NICU).Methods: Data on the milk production of women who gave birth to preterm babies at a tertiary teaching hospital was collected between 2010 and 2013. Mothers logged their pumping sessions, and milk was brought to the NICU in accordance with hospital policies.Results: Eighty-one mothers were enrolled in the study. Thirteen (16%) who did not return any logs were excluded from the data analysis. Of the remaining 68 mothers, 16 (24%) began pumping within 6 hours of the birth, whereas 52 (77%) did not. On Day 1, the average daily volume of breast milk pumped was 6 ml (SD = 10, range 0–63 ml). By Day 5, the average daily volume pumped increased to 285 ml (SD = 221, range 0–823 ml).Conclusion: There is a wide range in milk production for mothers of preterm infants, thus highlighting the need for evidence-based information and continuous encouragement of mothers to provide this valuable resource to the very vulnerable preterm infants.
43
Shi, Jin, Yaping Yue, Weiping Zhao e Qiaoqiao Huang. "Towards the Sustainable Development of Young Children: Impact of After-School Tutoring on Chinese Preschoolers’ Social Behavior". Sustainability 15, n. 1 (22 dicembre 2022): 181. http://dx.doi.org/10.3390/su15010181.
Testo completoAbstract (sommario):
This study aimed to examine whether participation in more types of after-school tutoring for 3- to 6-year-old preschool children is more beneficial to their social behavior. The study was based on survey data collected from 823 children aged between 3 and 6 years in Beijing City, the Guangdong Province and the Jiangsu Province, China. Binary logistic regression and hierarchical multiple regression results revealed that: (1) gender, age, and family socioeconomic status were important factors that affected whether preschool children participated in after-school tutoring; (2) in terms of the types of after-school tutoring, participation in the arts and health-related activities was beneficial to the development of children’s social skills, participation in arts and science ameliorated children’s problem behavior, but participation in arts, science, and health-related activities simultaneously posed a negative impact on children’s problem behavior; (3) in terms of the breadth of participation, children’s social skills were weakly strengthened if the participation breadth is greater, but this, however, did not reduce problem behavior; (4) parental involvement and individual factors were important in determining children’s social behavior. Based on the findings of this study, we suggest that parents should carefully consider the impact of after-school tutoring on preschool children’s social behavior and choose after-school tutoring appropriately.
44
MIZOGUCHI, Wataru, Katsuya FUKUDA, Qiusheng LIU e Sutopo P. Fitri. "823 Pool Boiling Critical Heat Flux of Horizontally Vertical Ribbon in FC-72". Proceedings of Conference of Kansai Branch 2008.83 (2008): _8–27_. http://dx.doi.org/10.1299/jsmekansai.2008.83._8-27_.
Testo completo
45
Tappe, Frank, Christian Schwickert e Rainer Pöttgen. "Dimorphic EuCu5Cd". Zeitschrift für Naturforschung B 67, n. 10 (1 ottobre 2012): 1107–14. http://dx.doi.org/10.5560/znb.2012-0109.
Testo completoAbstract (sommario):
Two modifications of EuCu5Cd were synthesized from the elements in sealed tantalum ampoules.The high-temperature (HT) modification was obtained from an induction-melted sample that was finally annealed at 873 K, while the low-temperature (LT) phase is formed in a muffle furnace by annealing a pre-melted sample at 673 K. DSC measurements gave a transition temperature of 823±2 K. Both structures were refined on the basis of single-crystal X-ray diffractometer data: R3̄m, a = 511:58(7), c = 3059:6(6) pm, wR2 = 0.0289, 316 F2 values, 22 variables for HTEuCu4 :85(1)Cd1:15(1) and Pnma, a = 2545:6(5), b = 511:60(1), c = 1060:3(2) pm, wR2 = 0.0386, 2044 F2 values, 121 variables for LT-EuCu4:92(1)Cd1:08(1). A small degree of Cu/Cd mixing was observed for three sites. Both structures adopt new types. The europium atoms have high coordination numbers of 18, 19 and 20 in LT- and 18 and 20 in HT- EuCu5Cd. These three types of polyhedra are the basic building units also in the closely related structures of CeCu6, CeCu5Au, CeCu4:38In1:62, and CeNi5Sn, a family of stacking variants. Temperature-dependent magnetic susceptibility measurements of a HT- EuCu5Cd sample showed an experimental magnetic moment of 7.56(1) μB per Eu atom in the paramagnetic regime, compatible with divalent europium. HT- EuCu5Cd orders antiferromagnetically at 17.7(5) K.
46
Finch, Rebecca Elizabeth, Kevin McGeechan, Anne Johnstone e Sharon Cameron. "Impact of self-administration of misoprostol for early medical abortion: a prospective observational cohort study". BMJ Sexual & Reproductive Health 45, n. 4 (17 agosto 2019): 296–301. http://dx.doi.org/10.1136/bmjsrh-2018-200278.
Testo completoAbstract (sommario):
IntroductionIn October 2017, Scotland legalised the home use of misoprostol for the purpose of early medical abortion (EMA). Women up to 9+6 weeks’ gestation can now self-administer the drug at home, 24–48 hours after receiving mifepristone in the clinic.ObjectiveTo evaluate the impact of this change on the uptake and success rate of EMA, and on the provision of effective contraception on discharge.MethodsA prospective observational study was conducted to compare the outcomes of two cohorts of women in the 6 months before and 6 months after the introduction of home administration of misoprostol. The main outcome measures were uptake of EMA, success of EMA and provision of long-acting reversible contraception (LARC) to women undergoing EMA.ResultsThere was a statistically significant increase in the uptake of EMA from 698/1075 (64.9%) women in the first study period to 823/1146 (71.8%) in the second study period. There was no statistically significant difference in the success rate of EMA: 99.3% and 98.9% in clinic and home misoprostol cohorts, respectively. There was also no statistically significant difference in the proportion of women provided with LARC: 37.7% and 33.7% in clinic and home misoprostol cohorts, respectively.ConclusionsSelf-administration of misoprostol at home increased uptake of EMA, with no effect on the high success rate that was previously seen with clinic administration of misoprostol. In addition, the reduced number of visits associated with home use of misoprostol has not affected the provision of effective contraception to women.
47
Liu, Yu, Yan Zhao, Chongxu Han e Chuanli Ren. "Expression of CDK6 in Stomach Cancer and the Effect of CDK4/6 Inhibitor PD-0332991 on the Function of Stomach Cancer Cells". Computational and Mathematical Methods in Medicine 2022 (30 aprile 2022): 1–8. http://dx.doi.org/10.1155/2022/2402567.
Testo completoAbstract (sommario):
Objective. To study the expression and prognostic value of CDK6 in stomach cancer and the function of CDK4/6 inhibitor PD-0332991 on the proliferation of stomach cancer cells. Methods. Immunohistochemistry was used to detect the expression of CDK6 in stomach cancer tissues and adjacent normal tissues and to analyze the effect of CDK6 on clinicopathological parameters of stomach cancer patients. Kaplan-Meier plotter was employed to study the relationship between CDK6 and overall survival in stomach cancer. Western blot and RT-PCR were used to detect protein and gene expression of CDK6 in different cells. The effects of CDK4/6 inhibitor PD-0332991 on apoptosis and aging of stomach cancer cells were detected by flow cytometry and β-galactosidase aging staining assay. The effects of CDK4/6 inhibitor PD-0332991 on the invasion and migration of stomach cancer cells were explored by the wound healing experiment and the Transwell experiment. The supernatant of stomach cancer cells was collected, and the effect of CDK4/6 inhibitor PD-0332991 on tumor markers of stomach cancer cells was detected by biochemical immunoassay. Results. (1) CDK6 was highly expressed in stomach cancer tissues and cells. (2) Abnormally elevated CDK6 expression results in shorter survival in stomach cancer patients. (3) CDK4/6 inhibitor PD-0332991 could block the proliferation of stomach cancer cells, but not stomach epithelial proliferation. PD-0332991 could inhibit the secretion of pro-GRP by MGC 823. (4) PD-0332991 could advance the development of the apoptosis and senescence of stomach cancer cells and suppressed the invasion and migration of stomach cancer cells. Conclusion. CDK6 expression is elevated in gastric cancer, and the CDK4/6 inhibitor PD-0332991 can remarkably promote apoptosis and senescence of stomach cancer cells and effectively inhibit the migration and invasion of stomach cancer cells.
48
BENSON, JACK A. "A Novel Gaba Receptor in the Heart of a Primitive Arthropod, Limulus Polyphemus". Journal of Experimental Biology 147, n. 1 (1 novembre 1989): 421–38. http://dx.doi.org/10.1242/jeb.147.1.421.
Testo completoAbstract (sommario):
1. The isolated, intact heart of the marine arachnid Limulus polyphemus continues to beat in vitro for many hours. Application of γaminobutyric acid (GABA) decreased the heart beat frequency with a threshold of 3xlO−7 moll−1 and an EC50 of 2.0±0.6xlO−5 moll−1 (mean±s.D., N = 8). At lO−4moll−1 and above the heart beat was completely and reversibly inhibited. 2. The agonist potency profile of the Limulus heart chronotropic GABA receptor was very similar to that of the vertebrate GABAA receptor: muscimol > ZAPA>GABA=⋍TACA>isoguvacine>THIP>3-aminopropane sulphonic acid> imidazole-4-acetic acid ⋍ß-guanidino proprionic acid ⋍5-aminovalerate. In contrast, the antagonist profile differed dramatically: bicuculline, pitrazepin and SR 95103, as well as the channel blocker picrotoxin, were without effect at concentrations up to 10−4moll−1. 3. The benzodiazepines clorazepate, flunitrazepam, flurazepam and diazepam, as well as the barbiturate sodium pentobarbital, were without effect on the GABA response, suggesting that the Limulus heart GABA receptor is not complexed with the benzodiazepine and barbiturate modulatory subunits that characterize vertebrate GABAA receptor. 4. The GABAB ligands baclofen, phaclophen and kojic amine were inactive on the heart. However, 3-aminopropyl-phosphonous acid (CGA147 823), a potent and highly selective GABAb agonist, was the most active of the compounds tested. It inhibited the heart beat with a threshold of about SnmolP1, an EC50 of 4.0±2.7×10−7 mol1−1, and produced total inhibition of the heart at 10−5moll−1. CGA 147 823 was inactive on the locust thoracic somal GABA receptors. 5. cis-4-aminocrotonic acid (CACA), the ligand defining a proposed GAB Actype receptor, was inactive on the heart. 6. The GABA-induced inhibition of the heart beat was enhanced by pretreatment with the GABA uptake inhibitor nipecotic acid but not with sodium valproate or ß-alanine. 7. The Limulus heart chronotropic GABA receptor appears to be of a hitherto undescribed type that differs in pharmacology from the vertebrate GABAA and GABAB receptors as well as from the well-defined GABA receptors on the somata of locust neurones and the muscle fibres of insects and the nematode Ascaris.
49
Zhang, Tao, Chang Liu, Shi Huang, Yuanping Ma, Jiansong Fang e Yuanneng Chen. "A Downmodulated MicroRNA Profiling in Patients with Gastric Cancer". Gastroenterology Research and Practice 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/1526981.
Testo completoAbstract (sommario):
Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a subset of 6 paired samples. The stem-loop quantitative real-time polymerase chain reaction (qRT-PCR) assay was subsequently performed to confirm the sequencing results in the remaining 6 paired samples. The profiling results were also validated in vitro in three human GC cell lines (BGC-823, MGC-803, and GTL-16) and a normal gastric epithelial cell line (GES-1). Results. The miR sequencing approach detected 5 differentially expressed miRs, hsa-miR-132-3p, hsa-miR-155-5p, hsa-miR-19b-3p, hsa-miR-204-5p, and hsa-miR-30a-3p, which were significantly downmodulated between the tumoral and peritumoral GC tissues. Most of the results were further confirmed by qRT-PCR, while no change was observed for hsa-miR-30a-3p. The in vitro finding also agreed with the results of both miR sequencing and qRT-PCR for hsa-miR-204-5p, hsa-miR-155-5p, and hsa-miR-132-3p. Conclusion. Together, our findings may serve to identify new molecular alterations as well as to enrich the miR profiling in human GC.
50
Liu, S. M., L. O'Brien e S. G. Moore. "A single recessive gene confers effective resistance to powdery mildew of field pea grown in northern New South Wales". Australian Journal of Experimental Agriculture 43, n. 4 (2003): 373. http://dx.doi.org/10.1071/ea01142.
Testo completoAbstract (sommario):
Reactions to powdery mildew (Erysiphe pisi Syd.) of a range of varieties, advanced lines and pea germplasm from the Australian Temperate Field Crops Collection (ATFCC) were evaluated under field conditions at Narrabri, New South Wales. Thirteen resistant genotypes, including 3 M257 sister lines [M257-2-1 (Mukta), M257-3-6 and M257-5-1], Glenroy, Kiley and PSI 11 from Australian breeding programs, and LE 25 (ATC 1275), ATC 649, ATC 767, ATC 823, ATC 1036, ATC 1121 and ATC 1181 from the ATFCC, along with 8 susceptible lines Dinkum, Bohatyr, Jupiter, Greenfeast, Solara, P441-6, Trapper and Cressy Blue, were used to make resistant × resistant, resistant × susceptible and susceptible × susceptible combinations to examine the inheritance of resistance. Parental lines and F1 and F2 populations were evaluated in the field under natural disease epiphytotics at the Plant Breeding Institute, Narrabri, during the winters of 1996 and 1997. In 1996, resistant and susceptible F2 plants were selected from 5 crosses, and further examined as F3 families in 1997. No fully resistant line was identified among the parents. F1 reactions indicated that resistance was governed by recessive genes and there were no maternal effects. Segregation patterns in the F2 and F3 generations supported the hypothesis of resistance in the genotypes M257-5-1, Glenroy, Kiley, ATC 649 and ATC 1121 being conferred by the same single recessive gene.