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Pires, Diego Paiva. "Modelo de Kane 8 × 8 para a estrutura eletrônica de wurtzitas". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/76/76131/tde-19032013-165854/.
Testo completoThe spin-orbit interaction has played a crucial role in the development of low-dimensional semiconductor devices. In recent results addressing the 8 × 8 Kane model for cubic systems, particularly zincblende lattices, effective hamiltonians for the conduction band are calculated in a semi-analytical way. By folding down the Kane hamiltonian, the spinor components in the conduction band are isolated, resulting in an equation having the energy in denominators. Through a linearization process, controlled by a power expansion in the inverse of the energy gap, the energy is removed from the denominators and an effective hamiltonian is obtained. In a zincblende system, terms dependent on spin only appear in the effective hamiltonian of second order in the inverse of the energy gap of a heterostructure [PRL 99, 076603 (2007); PRB 78, 155313 (2008)]. In this masters thesis we apply this semi-analytical procedure to generate effective hamiltonians for the conduction band of wurtzite systems. Using the symmetries of the hexagonal lattice, the 8 × 8 Kane model is reviewed by taking into account all couplings mediated by the linear momentum and spin angular momentum. We show that exists an unified treatment for the Kane model of zincblende and wurtzite systems, which can be very useful in studies with nanowhiskers. We have found a first-order effective Hamiltonian having terms dependent on spin even in the bulk case. One of these spin-dependent terms is the helicity operator. The spin-orbit interaction only appears in the second order expansion. Considering the first order hamiltonian, we have calculated the Zitterbewegung effect and discussed the Datta-Das transistor. We have found that only the spin operators exhibit the Zitterbewegung effect. The linear dependence with time shown by the position operators make of the spin operators harmonic fields, which form spin grattings similar to those found in zincblende heterostructures (persistent spin helix). We have also included a radiation field and calculated the (direct) optical transitions assisted by spin. We have found that the transition rates are harmonic functions of the incidence angle.
Tallant, Shane, Michael Martin e Scott Hedrick. "Analysis of contractor logistics support for the P-8 Poseidon Aircraft". Monterey California. Naval Postgraduate School, 2008. http://hdl.handle.net/10945/10350.
Testo completoThis study assesses the costs as an independent variable (CAIV) of the maintenance manpower of both the original equipment manufacturer (OEM) contractor logistics support (CLS) and an estimated organic Navy compliment for the P-8 Poseidon program. Comparisons to similar aircraft procurements will be analyzed for possible benefits and limitations regarding a single source provider of CLS. Furthermore, current logistic acquisition culture and operational impacts will be reviewed in order to determine feasibility and possible further research.
Strieder, Frank. "Astrophysikalischer S-Faktor von 7Be(p, [gamma]8B [7 Be(p, gamma) 8 B] verbesserte und neuartige Messtechniken /". [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960207341.
Testo completoTallant, Shane Hedrick Scott Martin Michael. "An analysis of contractor logistics support for the P-8 Poseidon Aircraft". Monterey, Calif. : Naval Postgraduate School, 2008. http://handle.dtic.mil/100.2/ADA483513.
Testo completoAdvisor(s): Petross, Diana ; Kang, Keebom. "June 2008." "MBA professional report"--Cover. Description based on title screen as viewed on August 8, 2008. Includes bibliographical references (p. 79-81). Also available in print.
Boer, Jason. "Mechanistic investigation of cytochrome P450 1A2 catalyzed metabolism of 8-alkylxanthines /". Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8161.
Testo completoCaruso, Melania <1989>. "Sistema sanitario americano e sistema sanitario italiano a confronto nell'Azienda ULSS 8 Berica". Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21092.
Testo completoSchümann, Frank. "Messung des astrophysikalischen S-Faktors der Reaktion 7Be(p, [gamma]8B [7 Be(p, gamma) 8 B] durch Coulombaufbruch von 8B". [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965035581.
Testo completoKamath, Arati B. "Apoptosis as a Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immunotoxicity". Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/40094.
Testo completoPh. D.
Simoniello, R. "MEASUREMENT OF MISSING TRANSVERSE MOMENTUM AND SEARCH FOR H->TAUTAU IN P-P COLLISIONS AT SQRT{S}=8 TEV WITH ATLAS". Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/230543.
Testo completoXian, Kenneth Yijing. "P-type ATPases studied by electron microscopy and two-dimensional crystallization /". Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3778-8/.
Testo completoRicciardulli, Vittorio. "Analisi dello spettro di massa invariante j/psi pi+ pi- in collisioni p-p a sqrt(s) = 8 tev con il rivelatore cms". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/6617/.
Testo completoBennett, Joe. "A critical social semiotic study of the word chav in British written public discourse, 2004-8". Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1485/.
Testo completoBorgwardt, Derek Steven. "Histatin 5 attenuates IL-8 dendritic cell response to gingivalis Hemagglutinin B". Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/926.
Testo completoBALL, JACQUES. "Transmission, diffusion elastique et reconstruction directe des amplitudes n-p entre 0. 8 et 1. 1 gev". Paris 11, 1992. http://www.theses.fr/1992PA112187.
Testo completoTomida, Natsuki. "Search for η’-nucleus bound states from ¹²C(γ, p) reaction with simultaneous detection of decay products". Kyoto University, 2020. http://hdl.handle.net/2433/258972.
Testo completoSpezzapria, Mario. "A linha metafísica do belo: estética e antropologia em K. P. Moritz". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/8/8133/tde-05102017-184315/.
Testo completoIn this work I propose to find out in the thought of Karl Philipp Moritz (1756- 1793) a homogeneous and coherent philosophical position, whose theoretical structures are paradigmatically exemplified in his aesthetical theory, which at least in part constitutes their seminal place. In short, Moritz\'s aesthetics presents itself both as an ample reflexion on totality, and as a theory of the intrinsic value of any individuality, themes that he transposed to the reflexion on man. At the heart of his aesthetical and anthropological thought lies the question: how an \"object\" (a work of art, or the character or taste of a people, or of a singular individual) can be thought in its autonomous value? Question that presupposes the experience of a lack, a lost of sense, and at the same time the man\'s constant effort to reproduce this \"objective\" value (a tension for the ideal of a whole completed totality), while human life remains essentially dominated by limitation, destruction, grief and failure. By learning to deal with a whole and complete totality (the artistic object), aesthetics becomes a paradigm for the comprehension of further domains (humanity, nature, history), and an instrument of appreciation of life as a \"work of art\".
Zhou, Qin. "The Impact of Substance P (SP) N-Terminal Metabolite SP1-7 in Opioid Tolerance and Withdrawal". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5174-8/.
Testo completoPeruzzo, Pierangela <1998>. "La finanza sostenibile e i fondi di investimento classificati Art.8 e Art.9 secondo il Regolamento SFDR: analisi empirica". Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21423.
Testo completoCreusen, Charlotte M. "Phaseneigenschaften von pentakoordinierten 18-e-d8-Übergangsmetall-p-Allyl-Komplexen [18-e-d-8-Übergangsmetall-Pi-Allyl-Komplexen]". Aachen Mainz, 2009. http://d-nb.info/995293791/04.
Testo completoDelmas, Frédéric. "L'acide 3-Désoxy-D-Manno-2octulosonique 8-Phosphate (KDO-8-P) synthase chez les plantes : caractérisation fonctionnelle d'une enzyme impliquée dans la biosynthèse d'un composé pectinique des parois végétales". Bordeaux 2, 2004. http://www.theses.fr/2004BOR21104.
Testo completoThe KDSA gene codes for the 3-deoxy-D-manno-octulosonic acid 8-phosphate (Kdo-8-P) synthase which synthesizes the phosphorylated precursor of Kdo, an essential and indissociable component of the outer membrane in Gram-negative bacteria. In plants, the role of Kdo is largely misunderstood ; however it is a constituent of a complex pectic polysaccharide : rhamnogalacturonan II, essential for the structuration of the pectin bnetwork in primary cell wall. The study of the KDSA enzyme has been performed in tomato (Lycopersicon esculentum Mill. ) and in Arabidopsis thaliana. The expression of KDSA was shown to be preferentially associated with dividing cells. Its function is thought to be of great importance since no null mutant plants, lacking the Kdo-8P synthase activity, could be isolated. A preliminary study of the Kdo transferase has been performed. This enzyme is the last one of the biosynthetic pathway of Kdo and the first results will be discussed
Sobral, Fabio Maia. "Os grundrisse de 1857-8 como manifesto social". [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/280129.
Testo completoTese (doutorado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas
Made available in DSpace on 2018-08-11T18:11:41Z (GMT). No. of bitstreams: 1 Sobral_FabioMaia_D.pdf: 743243 bytes, checksum: a8598ae1636e2bea3cbadcd97c075b78 (MD5) Previous issue date: 2008
Resumo: Apresentamos a obra Grundrisse de Marx, escrita em 1857-1858, como um ¿Manifesto Social¿ que expõe os pontos programáticos a serem implementados por uma sociedade que substituísse o modo de produção capitalista, o comunismo. Os Grundrisse seriam um programa elaborado por Marx para orientar a luta da classe operária como programa da revolução. Marx esperava que a crise financeira de 1857 se transformasse em crise mundial, o que poderia fazer com que estourasse uma revolução, assim como ocorrera em 1848. Os Grundrisse desempenhariam uma tarefa tríplice: crítica ao socialismo proudhonista, que buscava reformar o mercado para eliminar a exploração; análise dos fundamentos do sistema capitalista, de seus pilares de sustentação; proposição dos elementos constitutivos da sociedade comunista. Para realizar estas tarefas, Marx analisa ainda o funcionamento das sociedades anteriores ao domínio do capital. Apresentamos no primeiro capítulo as análises de Roman Rosdolsky e Antonio Negri sobre o papel desempenhado pelos Grundrisse. Rosdolsky defende a concepção de que esta obra é um caminho em direção a O Capital, algo que seria demonstrado pelos planos de Marx para a criação de sua obra. Negri compreende os Grundrisse como obra de antagonismo e combate ao capitalismo. Afirmamos que os Grundrisse são um programa para a revolução e que não está além ou aquém d¿O Capital, sendo apenas distinto na linguagem por estarem em épocas diferentes da luta revolucionária; aqueles teriam uma linguagem de manifesto social para o combate, já este seria a demonstração científica ¿ na concepção de nova ciência em Marx ¿ da crítica da economia política. Aqui, demonstramos ainda que Marx dedica atenção especial à luta contra os princípios oportunistas do proudhonismo, que buscavam manter a sociedade da mercadoria e do mercado. No segundo capítulo expomos o método dialético de Marx desenvolvido na ¿Introdução¿ de 1857, texto suprimido por Marx, mas que, afirmava ele, expunha as conclusões de sua ciência. No terceiro capítulo expomos os princípios das sociedades anteriores ao capitalismo, os ¿princípios do passado¿, os seus fundamentos, em um jogo dialético de positivo e negativo, entre o que deveria ser aproveitado pelo comunismo e o que deveria ser evitado. No quarto e quinto capítulos expomos os ¿princípios do presente¿, da sociedade dominada pelo capital, através das categorias dinheiro (quarto capítulo). Apresentamos nestes os fundamentos a serem extirpados pela luta da classe operária, os elementos que definem a especificidade da sociedade capitalista. Por fim, no quinto capítulo apresentamos os ¿princípios do futuro¿, o programa da revolução para a construção da sociedade comunista. Este é o ponto central de nosso trabalho: tentar provar que Marx busca dar orientações às lutas da classe operária para que ela possa erradicar a sociedade capitalista, e tal erradicação somente poderia ser efetivada com um programa correto e que destruísse os fundamentos sociais e econômicos da sociedade de mercado. Os Grundrisse, ao realizarem tal papel, se tornariam um manifesto à revolução, um novo manifesto comunista, um ¿manifesto social¿ por uma sociedade do futuro.
Abstract: We present the work of Marx intituled Grundrisse, written in 1857-1858, as a "Social Manifesto" which sets out the points of a programme to be implemented by a society to replace the capitalist mode of production, the communism. The Grundrisse would be a programme drawn up by Marx to guide the struggle of the working class as a program of the revolution. Marx hoped that the financial crisis of 1857 to become a world crisis, which could make it brings a revolution, as occurred in 1848. The Grundrisse would a triple task: criticism of proudhonist socialism, which sought to reform the market to eliminate the exploitation; analysis of the foundations of the capitalist system, its pillars of support; proposition of the constituent elements of communist society. To perform these tasks, Marx also examines the functioning of societies before domination of the capital. We present the analysis in the first chapter of Roman Rosdolsky and Antonio Negri on the role played by Grundrisse. Rosdolsky defends the idea that this work is a path towards The Capital, something that would be shown by the plans of Marx for the creation of his work. Negri comprises the Grundrisse as work of antagonism and anti-capitalism. We affirm that the Grundrisse is a program for the revolution and is not above or below The Capital, and only because they are distinct in language at different times of revolutionary struggle, and those would have a language of social manifesto for the fight, because this would be the scientific demonstration - in the design of new science in Marx - of criticism of political economy. Here, we demonstrate that Marx still devotes special attention to the fight against the principles of opportunistic proudhonism, who sought to keep the society's commodity and market. The second chapter expose the dialectic method of Marx developed at the "Introduction" of 1857, deleted text by Marx, but, he said, explained the foundations of their science. In the third chapter expose the principles of the societies prior to capitalism, the "principles of the past", their foundations, in a game dialectic of positive and negative, between what should be maintained by communism and what should be avoided. In the fourth and fifth chapters expose the "principles of the present", society dominated by capital, by category of money (the fourth chapter). We present these to be extirpated the reasons for the struggle of working class, the elements that define the specific nature of capitalist society. Finally, the fifth chapter presents the "principles of the future," the program of the revolution for the construction of communist society. This is the focus of our work: trying to prove that Marx seeks to give guidance to the struggles of the working class so that it can eradicate the capitalist society, and that eradication could only be effected with a correct program and that destroy the foundations of social and economic society of the market. The Grundrisse, in performing this role, would become a manifesto for revolution, a new communist manifesto a "social manifesto" by a society of the future.
Doutorado
Doutor em Filosofia
Burdová, Martina. "Návrhy na zlepšení služeb hotelu Slunce". Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2011. http://www.nusl.cz/ntk/nusl-223315.
Testo completoRapp, Insa [Verfasser], Eric P. [Akademischer Betreuer] Achterberg e Martin [Gutachter] Frank. "Trace metal sources and cycling in tropical oxygen minimum zones / Insa Rapp ; Gutachter: Martin Frank ; Betreuer: Eric P. Achterberg". Kiel : Universitätsbibliothek Kiel, 2018. http://nbn-resolving.de/urn:nbn:de:gbv:8-diss-239971.
Testo completoLASCOMBE, MARIE-BERNARD. "Determination de la structure tridimensionnelle du fragment fab d'un anticorps murin anti-p-azophenylarsonate a 2. 8 angstroms de resolution". Paris 7, 1989. http://www.theses.fr/1989PA077081.
Testo completoFontana, álvaro. "Considerações a Respeito da Determinação de Parâmetros Eletrônicos de Moléculas Conjugadas por Meio de Medidas Eletroquímicas". UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2015. http://tede2.uepg.br/jspui/handle/prefix/8.
Testo completoFundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Paraná
In this work were performed organic synthesis of the monomer derivatives of poly (p-phenylenevinylene) whose main interest was to obtain a monomer with an aromatic ring having attached two bromine atoms (this step not being performed), a cyano group, a side chain of six carbon atoms and a sulfonic group linked to the end of side chain. The syntheses were performed starting from the compound 2,5-dimethylphenol and adding the aromatic ring an iodine atom, made subsequently replacing the iodine atom by a cyano group, and the sequences of reactions by adding a side chain with six carbon atoms attached at its one end a sulfonic group. The characterization of the obtained compounds was performed by spectroscopy techniques, Infrared, nuclear magnetic resonance 1H and 13C and GC-MS. These analyzes showed that the structures of the proposed monomers were achieved almost entirely. Part of this doctoral work was performed in the laboratory of the Emeritus Professor Dr. Alan Maxwell Bond at Monash University, Melbourne - Australia, such as sandwich doctorate program. The study in Australia comprised learning and application of cyclic voltammetry technique ac coupled to Fourier transform in chemical reactions studying the kinetics of 1 and 2 electron transfer, in this case, taking as an example the molecule N,N,N',N'-Tetramethyl-p-phenylenediamine, TMPD. The molecular solvents used for the study of electron transfer in the molecule TMPD were acetone and acetonitrile, and the following ionic liquids: [BMPIPTFSI], [BMIM] [TFSI], [BMIm][BF4] and [BDMIM] [TF2N]. In all the results obtained it was found the process known as internal reference, where the first electron transfer reaction in the molecule, because it is faster, can be used to compare the values of the thermodynamic and kinetic parameters obtained in the first process with the parameter values obtained in the second electron transfer process in the same molecule.
Neste trabalho foram realizadas sínteses orgânicas de monômeros derivados de poli(p-fenilenovinileno) cujo principal interesse foi a obtenção de um monômero com um anel aromático tendo ligado a ele, dois átomos de bromo (não sendo realizada essa etapa), um grupamento ciano, uma cadeia lateral com seis átomos de carbono, e um grupamento sulfônico ligado a extremidade da cadeia lateral. As sínteses foram realizadas partindo-se do composto 2,5-dimetilfenol e adicionando-se ao anel aromático um átomo de iodo, posteriormente feita a troca do átomo de iodo por um grupo ciano e nas sequências das reações adicionando-se uma cadeia lateral com seis átomos de carbono oposta ao grupo ciano e ligado na extremidade da cadeia lateral um grupo sulfônico. A caracterização dos compostos foi realizada através das técnicas, infravermelho, ressonância magnética nuclear 1H, 13C e CG-MS. Essas análises evidenciaram que as estruturas dos monômeros propostos foram alcançadas em quase sua totalidade. Parte deste trabalho de doutoramento foi realizada no laboratório do professor Emeritus Dr. Alan Maxwell Bond na Monash University em Melbourne – Austrália, como doutorado sanduíche. O estudo feito na Austrália compreendeu a aprendizagem e aplicação da técnica de voltametria cíclica ac acoplada à transformada de Fourier, estudando-se a cinética de transferência de 1 e 2 elétrons, neste caso, utilizando-se como exemplo, a molécula N,N,N′,N′-Tetramethyl-p-phenylenediamine, TMPD. Os solventes moleculares utilizados para o estudo da transferência de elétrons nesta molécula foram acetona e acetonitrila e também os seguintes líquidos iônicos: [BMPIPTFSI], [BMIM][TFSI], [BMIm][BF4] e [BDMIM][TF2N]. Em todos os resultados obtidos constatou-se o processo chamado de referência interna, onde, a primeira reação de transferência de elétrons nesta molécula, por ser mais rápida, pode ser utilizada para comparar os valores dos parâmetros termodinâmicos e cinéticos obtidos no primeiro processo de transferência de elétrons com os valores dos parâmetros obtidos no segundo processo na mesma molécula.
Pinheiro, Mauricio Mota Saboya. "A abordagem das práticas doxásticas à epistemologia de William Payne Alston: uma interpretação a partir da leitura de Thomas Reid". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/8/8133/tde-23052012-145104/.
Testo completoThis thesis aims at analyzing the bearings between William Payne Alstons doxastic practice approach and Thomas Reids theory of the intellectual powers of men. After surveying the epistemological concepts of Alston and Reid, one deeply examines the arguments of each other for the reliability of the basic modes of forming beliefs and, after that, one compares both authors. The comparative analysis suggests strong evidence for the claim that the essential elements of basic doxastic practices are rooted in Reids doctrine of intellectual powers. Also, fighting against skepticism concerning the reliability of the belief forming processes we are typically engaged in seems to have been a motivation for the development of both philosophical projects. But we have found important differences between them, especially concerning the role of skepticism, realism and theism as general conditions under which Alstons and Reids epistemological theories were built.
Zhu, Miaojun. "Rôle du Cholestérol, du 24S-hydroxycholestérol et des microdomaines sur la fonction de la P-glycoprotéine : possible implication dans la maladie d'Alzheimer". Paris 13, 2010. http://www.theses.fr/2010PA132016.
Testo completoAlzheimer’s disease (AD) is the most common dementia in elderly patients. Many studies have shown the importance of the amyloïd cascade in the pathology mechanisms of AD including the Aβ peptides. These peptides are substrates of many membrane transporters such as P-glycoprotein over-expressed in the blood-brain barrier (BBB). However, the existing relations between the cholesterol, its metabolites and AD are still poorly understood. Investigations by nuclear magnetic resonance (NMR) may evidence cholesterol metabolism impairment in AD as well as involvement of other metabolic pathways. The first goal of this work was to explore the effects of cholesterol and its brain metabolite, the 24S-hydroxycholesterol (24S-OH), on the transport activity of P-gp. Finally, through the NMR analysis of cerebral cortex fragments of patients, we studied the changes of lipid content and water-soluble metabolites of samples from patients with AD and those from patients with Amyotrophic Lateral Sclerosis (ALS). Our study suggests that P-gp and caveolin-1 modulate the rate of cellular cholesterol and its distribution within the plasma membrane, with an ATP-dependent mechanism only when this two proteins coexist. Moreover, 24S-OH modulates the P-gp function. For the first time an inhibition of P-gp by a metabolite of cholesterol was suggested. At least, NMR metabolomics has shown that some metabolic pathways are altered differently in the frontal cortex of patients with AD and the frontal cortex of patients with ALS
Mirghani, Rajaa A. "Quinine metabolism in man : emphasis on the 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 /". Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-174-8.
Testo completoVarese, Stefano. "MARCEL GRIAULE: Méthode de tethnographie. 1 vol. de 107 p., 8 ilustraciones en el texto y 11 planchas. Presse Universitaires, París, 1957". Pontificia Universidad Católica del Perú, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/113760.
Testo completoMurcia, Salazar Clara Paola. "THz emission from optimized p-doped silicon top devices". Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 64 p, 2007. http://proquest.umi.com/pqdweb?did=1338919401&sid=8&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Testo completoVignola, Jay S. "A study on the political cost savings associated with implementing airline pilot training curricula into the future P-8 MMA fleet replacement squadron". Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2006. http://library.nps.navy.mil/uhtbin/hyperion/06Jun%5FVignola.pdf.
Testo completoCastro, Cláudia Irene Emilio de. "Alterações cariotípicas dos cromossomos 7 e 8 em Síndromes Mielodisplásicas de novo (SMD-p) e sua correlação com variáveis biológicas de significado prognóstico". Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-24042015-150822/.
Testo completoMyelodisplastic Syndromes (MDS) are clonal disordes of hematopoietic stem cells characterized by ineffective hematopoiesis leading to blood cytopenias. They predominate in elderly patients and are associated with a high risk of progression to acute myelogenous leukemia (AML). The etiology of MOS is unknown in most cases (de novo) but about 10% of MDS are secondary to the use of xenobiotics, such as antineoplastic agents and organic solvents (secondary MDS). Though incurable, MDS patients have different clinical courses. Some patients can live for a decade with anemia being the only complaint whilst others present a very short term survival due to a rapid development of a treatment-refractory AML. Scales taking in account different biological aspects of the disease have been used in order to allocate patients in discrete risk levels. This risk stratification might help clinical decisions in a patient-by-patient basis. Most of these scales take in account the morphological subtype (FAB classification) and the cytogenetic status of the myelodysplastic clone. Chromosome abnormalities are very important markers of MDS. Most patients with this syndrome present cytogenetic aberrations which can be helpful in the diagnosis of SMD. Moreover, some of these aberrations have been correlated to a poorer prognosis, such as monosomy 7 and trissomy 8. These aneuploidies have been investigated by conventional (G-Banding) and molecular cytogenetic studies (In Situ Hybridization - FISH). In order to compare the efficiency of both techniques and to define the frequency and significance of monosomy 7 and trisomy 8 in MDS in a single institution population, chromosome studies of 28 patients were performed in metaphases by G-banding and in interphases by FISH (α satellite probes), before chemotherapy treatment. Chromosome studies by both techniques were obtained for 19 patients; monosomy 7 was detected by FISH in 6 patients; only one of these has been detected by conventional cytogenetics. Clinical follow-up of this monosomy 7 group patients disclosed short survival and increased risk for developing AML. Five out of the six patients with monosomy 7 were previously classified as the FAB subtypes of poor prognostic. 2 patients presented trisomy 8 in this series and were detected by both techniques. No difference in survival could be seen in these patients. Our results demonstrate that FISH is much more efficient to investigate chromosome numerical anomaly (at least monossomy 7) with prognostic relevance. This is specially true mainly when bone marrow samples lack metaphases since the studies can be performed in interphases cells.
Sylvestre, Florence. "La dernière transition glaciaire-interglaciaire (18 000-8 000 14C ans B. P. ) des Andes tropicales du Sud (Bolivie) d'après l'étude des diatomées". Paris, Muséum national d'histoire naturelle, 1997. http://www.theses.fr/1997MNHN0009.
Testo completoVignola, Jay S. "A study on the potential cost savings associated with implementing airline pilot training curricula into the future P-8 MMA fleet replacement squadron". Thesis, Monterey California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/2704.
Testo completoSilva, Marcelle Figueira Marques da. "Rotavírus a genótipos G5 e G1 associados ao genótipo P[8] circulando no Brasil de 1986 a 2013variabilidade genética pré e pós-vacinação". reponame:Repositório Institucional da FIOCRUZ, 2014. https://www.arca.fiocruz.br/handle/icict/12122.
Testo completoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Os rotavírus da espécie A (RVA) são os principais agentes etiológicos causadores de gastroenterite aguda (GA) em crianças \2264 5 anos e, anualmente, são responsáveis por aproximadamente 196.000 casos de óbito infantil em todo o mundo. Diferentes mecanismos genéticos (mutações pontuais, rearranjos genéticos, reestruturação de segmentos genômicos (reassortment) e recombinação genética) estão envolvidos na geração de variabilidade genética destes vírus. As combinações genotípicas mais encontradas mundialmente são: G1P[8], G2P[4], G3P[8], G4P[8] e G9P[8], entretanto, os países em desenvolvimento apresentam uma maior variabilidade genotípica entre as cepas circulantes. No intuito de se compreender a diversidade dos RVA, em 2011 foi proposto um novo sistema de classificação para os RVA baseado no sequenciamento nucleotídico dos onze segmentos gênicos destes vírus. No presente estudo foram realizadas análises filogenéticas dos onze genes de 28 cepas brasileiras de RVA de genótipo G5P[8] coletadas entre 1986 e 2005, 90 cepas de RVA de genótipo G1P[8] em diferentes regiões brasileiras entre 1986 e 2013, além do perfil de flutuação do genótipo P[8] no Brasil durante as últimas 3 décadas Os resultados demonstraram que as cepas brasileiras de genótipo G5P[8] e G1P[8] possuem uma constelação gênica do genótipo Wa-like (I1-R1-C1-M1-A1-N1-T1-E1-H1), com exceção de duas cepas G1P[8], que apresentaram o genótipo T3 (genótipo AU-1-like), comumente detectado em felinos. Foi proposta a classificação do genótipo G5 em 3 linhagens diferentes (I, II e III), de modo que a linhagem I circulou no Brasil entre 1986 e 2005 e a linhagem que está circulando atualmente entre países dos continentes Africano e Asiático pertencem à linhagem III. Os resultados permitiram demonstrar que a prevalência do genótipo G1P[8] variou anualmente no Brasil e que o genótipo G1 circulou em associação com as linhagens P[8]-1, P[8]-2 e P[8]-3 no país. A vacina RV1 apresenta especificidade P[8]-1, enquanto as cepas que estão circulando atualmente são P[8]-3. A análise do perfil de P[8] no Brasil demonstrou que no país circularam as linhagens P[8]-1, P[8]-2 e P[8]-3 e a variabilidade verificada para a linhagem P[8]-3 permitiu a sua classificação em 6 sublinhagens (P[8]-3.1 \2013 P[8]-3.6). Portanto, a melhoria dos programas de vigilância de RVA através de estudos que incluam a análise dos 11 segmentos gênicos das cepas circulantes no país contribuirá para entender melhor alguns pontos ainda não esclarecidos a respeito da biologia dos RVA, como de que maneira a introdução de um esquema de vacinação em massa pode influenciar na circulação de RVA em humanos e animais e a real frequência de detecção de eventos de reassortment entre cepas de espécies diferentes ou entre cepas selvagem e vacinal na população
Specie A rotaviruses (RVA) are the main etiological agent of acute gastroenteritis (AG) in children ≤ 5 years old and, annually, are responsible for about death of 196.000 children worldwide. Different genetic mechanisms (pontual mutation, genetic rearrangement, reassortment and genetic combination) are involved in the generation of variability of this viruses. The most detected combinations worldwide are: G1P[8], G2P[4], G3P[8], G4P[8] and G9P[8], however developing countries have strains with a greater genotypic variability. In order to unsderstand the RVA diversity, in 2011, was proposed a new classification system for RVA based on the nucleotide sequencing of the 11 gene segments. In the present study were conducted Phylogenetic analyses of the 11 gene segments from 28 brazilian RVA strains genotype G5P[8] collected between 1986 and 2005, 90 RVA strains genotype G1P[8] collected between 1986 and 2013 in different regions of the country, besides the analysis of the fluctuation profile from genotype P[8] during the last 3 decades in Brazil. The results showed that brazilian RVA strains genotypes G5P[8] and G1P[8] have a genectic constellation characteristic of the genotype Wa-like (I1-R1-C1-M1-A1-N1-T1-E1-H1), except for 2 G1P[8] strains, which showed genotype T3 (AU-1-Like), generally detected in felines. Was proposed the classification of genotype G5 in 3 different lineages (I, II and III), lineage I circulated in Brazil between 1986 and 2005, while the lineage actually circulating in African and Asiatic continents is lineage III. The results demonstrated that the G1P[8] prevalence in Brazil changed annually and genotype G1 circulated in Brazil in association to P[8]-1, P[8]-2 and P[8]-3 lineages. RV1 vaccine shows P[8]-1 specificity, whilst the actually circulating strains have P[8]-3 specificity. The analysis of the P[8] genotype profile demonstrated that P[8]-1, P[8]-2 and P[8]-3 lineages circulated in Brazil and the P[8]-3 variability enabled the classification into 6 sublineages (P[8]-3.1 – P[8]-3.6). Therefore, the enhancement of surveillance RVA programs through studies that include analysis of the 11 gene segments of strains circulating in the country contribute to better understand some points that remain unclear about the RVA biology, such as how the introduction of a mass vaccination scheme can influence the circulation of RVA in humans and animals and the actual frequency of reassortment events between strains of different species or between wild and vaccine strains in the population.
Ccantuta, Chirapo Karlos Alexander. "Controle de potência do gerador de relutância variável de 12/8 utilizando o controlador fuzzy pi auto-ajustável". reponame:Repositório Institucional da UFABC, 2018.
Cerca il testo completoCoorientador: Prof. Dr. José Alberto Torrico Altuna
Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Engenharia Elétrica, Santo André, 2018.
Este trabalho apresenta o controle de potência do gerador de relutância variável de 12/8 utilizando o controlador Fuzzy PI auto-ajustável e o controlador P+ressonante para o conversor conectado à rede elétrica. Inicialmente são estudados os princípios de operação da máquina e a topologia do conversor eletrônico de potência. Usando o software de simulação Matlab/Simulink é implementado o modelo da máquina de relutância variável utilizando as curvas características de corrente e de torque. Com o objetivo de controlar a potência gerada pela máquina e utilizando seu modelo matemático dinâmico projeta-se o controlador PI, e implementa-se o controlador Fuzzy PI auto-ajustável para atingir o mesmo objetivo. Assim, projeta-se também um controlador PI para o controle da tensão CC além de um controlador P+ressonante com o objetivo de melhorar a resposta em regime permanente da potência injetada na rede elétrica. Para este propósito é utilizado um conversor monofásico de dois níveis. Os resultados das simulações mostram o bom desempenho do sistema proposto e o controlador de potência é validado também através de resultados experimentais.
This work presents the power control of the 12/8 variable reluctance generator using Fuzzy self-tuning PI controller and the P+resonant controller for the converter connected to the electric network. Initially are studied the principles of operation of the machine and power electronic converter topology. Using the Matlab/Simulink simulation software is implemented the model of switched reluctance machine using the current and its torque characteristic curves. With the purpose of controlling the power generated by the machine and using his dynamic mathematical model is designed the PI controller, and the Fuzzy self-tuning PI controller is implemented to achieve the same objective. So, also is designed a PI controller for control of the link DC, in addition to the P+resonant controller with the objective of improving the response to its steady state of the injected power into the electric network. For this purpose it is used a single-phase two-level converter. The results of the simulations show the good performance of the proposed system and the power controller is validated by experimental results.
Neto, Alberto Paulo. "Entre o consenso e a contestação no Estado democrático de direito: uma interlocução entre a teoria democrática de J. Habermas e P. Pettit". Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/8/8133/tde-02072015-153958/.
Testo completoThe contemporary discussion on the organization of a political society to establish normative principles aimed at legitimizing the rule of law is at the epicenter of the grounds of deliberative democracy theories. Therefore, we inquire on structuring constitutional mechanisms that enable the exercise of political rights for the formation of public opinion. The thesis to be defended is that there are trouble spots in the deliberative theory of Habermas that hinder their implementation in social praxis. What we observe is the need to establish mechanisms for the protection of citizens before the instrumental means by which social system operate in late capitalist society. Therefore, with the help of contestatory democracy theory and the design of republican liberty, presented by Pettit, we aim to safeguard the discursive principles of Habermas\' theory of democracy and at the same time, enabling an expansion in the process of normative and discursive reconstruction of the democratic state of law. The republican theory of freedom as non-domination gives us a ploy to escape quandary in which contemporary theories of deliberative democratic are trapped in particular as regards the purpose of balancing the legitimacy under power communicative and their influence in shaping the administrative-state apparatus.
Barioni, Adriana. "Estudo da interação de núcleos de massa A=8 com alvo de carbono e da reação de captura 8Li(p,)9Be de interesse astrofísico". Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-13102009-133215/.
Testo completoThe measurements of the angular distributions for the elastic scatterings 12C(\'Li,\'Li) and 12C(8B,8B) reported in this work have been done in two laboratories. Those corresponding to the angular distributions for the elastic scattering 12C(8Li,8Li) were performed at two ene&ies, 20.6 MeV and 23.9 MeV, at the Pelletron Laboratory of the University of São Paulo. The *Li beam used in this laboratory had been produced in the RIBRASsystem. The measurements of angular distribution for the elastic scattering 12C(\'B,\'B) were performed at the Nuclear Structure Laboratory, at the University of Notre Dame, in the United States of America. The \'B beam was produced by the Twinsol system, at 25.8 MeV. The results obtained for total reaction cross section were included in a systematics\'together with other stable and exotic weakly bound nuclei and also with tightly bound ones, elastically scattered by 12C target. The data obtained from the literature were re-analised on the same framework of the data of this work. The reaction cross sections were obtained by fitting to the data, the cross secti\'ons calculated with the São Paulo potential. From the analysis one could conclude that no increase was observed in the total reaction cross section for the studied systems, indicating that effects, such as breakup, are not important for this system.
EZELIN, MARIE-CHRISTINE. "Suivi medico-physiologique du centre permanent d'entrainement et de formation de tennis au c. R. E. P. S. De reims chez 8 garcons minimes". Reims, 1989. http://www.theses.fr/1989REIMM068.
Testo completoDüppe, Marie Magdalena Verfasser], Karina [Akademischer Betreuer] [Reiß e P. J. [Gutachter] Saftig. "Untersuchung zur Bedeutung der sauren Sphingomyelinase für die ADAM10- und ADAM17-Aktivierung im Endothel / Marie Magdalena Düppe ; Gutachter: P. J. Saftig ; Betreuer: Karina Reiss". Kiel : Universitätsbibliothek Kiel, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:8-mods-2020-00029-3.
Testo completoHammache, Fairouz. "Mesures de la section efficace de la réaction $^7$Be(p,$\gamma)^8$B à basse énergie et implications dans le problème des neutrinos solaires". Phd thesis, Université Paris Sud - Paris XI, 1999. http://tel.archives-ouvertes.fr/tel-00002668.
Testo completoMacedo, Francisco Barbosa de. "O (re)fazer-se da historiografia: a obra de E. P. Thompson na produção discente do Programa de Pós-Graduação em História da Unicamp (1982-2002)". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/8/8137/tde-08032018-130327/.
Testo completoThis thesis investigates the reception, between 1982 and 2002, of the works of Edward Palmer Thompson (1924-1993) in student productions of the Postgraduate Programme in History of the University of Campinas, also known as Unicamp, (PPGHU). The institution stood out during this period for the significant number of references to Thompsonian texts, both in theses and dissertations, and the involvement of students and academics in the production of Brazilian editions of the writings of the English historian. Since the 1980s, E.P. Thompsons work has been indicated as one of the main influences on Brazilian historiography, being the object of recent systematic studies on its reception in the country. Based on theoretical and methodological considerations, especially from Roger Chartier (reading and appropriation) and Michel de Certeau (historiographical operation), and varied documentation (dissertations and theses, interviews, articles and reviews, bibliographic assessments and diverse institutional documents from PPGHU), we explore the relationship between the reception process previously mentioned and the changes experienced by university institutions of national historiographic production (accentuating specific aspects of PPGHU institutional dynamics), while additionally considering the social, political and cultural conjuncture of Brazil in the period (emphasising its impact on important current concepts among historians). We also investigate the circulation of national and foreign editions of E. P. Thompsons works, underlining the different forms of participation, in Brazilian editions, of both academics and students from PPGHU. Finally, we analyse the reading options of the Thompsonian work chosen by the latter, their appropriation, and the results in the work produced, taking into account how students developed a dialogue with historiographic debates and theoretical-methodological references that dominated the disciplinary (sub)fields to which they belonged. It is evident from our research that there are both creative and productive characteristics in the process of appropriation performed by the national historians here analysed, who were capable of bringing E.P. Thompsons concepts to territories he could hardly have imagined.
Anguiano, Bethany J. "The P-delta effects on the story drifts of steel moment frames /". Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1559856671&sid=8&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Testo completoSchönauer, Sebastian [Verfasser]. "Struktur-Wirkungsbeziehungen bei Homologen der Schlüsselaromastoffe 1-p-Menthen-8-thiol, 2-Furfurylthiol und 1-Phenylethanthiol sowie Spurenanalytik zum Nachweis von Thiolen in Früchten und Wein / Sebastian Schönauer". München : Verlag Dr. Hut, 2017. http://d-nb.info/1126295914/34.
Testo completoSchönauer, Sebastian M. [Verfasser]. "Struktur-Wirkungsbeziehungen bei Homologen der Schlüsselaromastoffe 1-p-Menthen-8-thiol, 2-Furfurylthiol und 1-Phenylethanthiol sowie Spurenanalytik zum Nachweis von Thiolen in Früchten und Wein / Sebastian Schönauer". München : Verlag Dr. Hut, 2017. http://nbn-resolving.de/urn:nbn:de:101:1-2017022423327.
Testo completoCarneiro, Natália Ketelut. "Modulação da resposta imune contra Paracoccidioides brasiliensis pelas vias canônica e não canônica do inflamassoma: participação da IL-1β, IL-18 e IL-1α no controle da infecção". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-08062017-093404/.
Testo completoGranuloma is a lesion characterized by a compact aggregate of mature phagocytes arising in response to a persistent stimulus. By driving uncontrolled innate immunity and tissue remodelling, IL-1 family pro-inflammatory mediators govern the pathophysiology of paracoccidioidomycosis, a granulomatous lung disorders caused by Paracocccidioides brasiliensis. A major inflammatory pathway involved in IL-1?, IL-18 e IL-1? secretion is the activation of inflammasomes, large multimolecular complexes best known for their ability to control activation of the proteolytic enzyme caspase-1. In this study we addressed the mechanisms that underlie canonical and non-canonical inflammasome pathways, assessing the functional importance of caspase-1, caspase-11 and caspase-8 in the regulation of inflammasome-mediated host resistance during P. brasiliensis infection. We found that IFN-?-mediated protective immune response following by caspase-1- dependent IL-18 release after is the key mechanism responsible for the fungal control after P. brasiliensis-induced cell damage recognition by NLRP3 canonical inflammasome pathway. Nonetheless, despite the important role of caspase-1 in the IL-1? maturation, the lack of caspase-1 only partially reduced IL-1? levels during P. brasiliensis infection. Unlike caspase-1, caspase-11 deficiency did not impair IL-1? production, cytokine strictly secreted by canonical caspase-1 inflammasome pathway. Instead, P. brasiliensis-triggered caspase-11 activation in an ill-defined manner leads to a rapid pore-mediated cell lysis and is required for IL-1? production during P. brasiliensis infection. IL-1?, in turn, is important for promoting the restriction of fungal growth trough IL-17-based inflammation. Finally, the caspase-8 induction by dectin-1/Syk signaling besides playing a role in mediating the caspase-1/11-independent IL-1? maturation is also required to efficient canonical caspase-1 inflammasome pathway, demonstrating a connected network between non-canonical caspase-8 and canonical caspase-1 inflammasome pathways to coordinate IL-1?. Taken together, our results revealed distincts contributions of both canonical and non-canonical inflammasome pathways in IL-1 family cytokine production and emphasizes the versatility of this platform to recruit several effector proteins to tailor the antifungal immune response, sheding new light on the complexity of this hostpathogen interaction.
Martin, Blanco Javier. "Study of J/Ψ production dependence with the charged particle multiplicity in p-Pb collisions at √sNN = 5. 02 TeV and pp collisions at √s = 8 TeV with the ALICE experiment at the LHC". Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=730dbcb5-68e6-4f80-b4f0-6de306fe2f6b.
Testo completoA suppression of the J/Ψ production was found in Pb- Pb collisions at √sNN = 2. 76 TeV, providing further evidence of the formation of a deconfined medium in ultrarelativistic heavy-ion collisions, the so-called Quark- Gluon Plasma. In addition, p-Pb collisions at √sNN = 5. 02 TeV have been studied at the LHC to measure cold nuclear matter effects (e. G. Gluon shadowing, energy loss, nuclear absorption). Understanding p-Pb collisions will help to disentangle hot and cold nuclear matter effects in Pb-Pb collisions. Surprisingly, some observables in p-Pb collisions behave as in heavy-ion collisions where it is understood as a result of a collective expansion of the medium. This thesis analyses inclusive J/Ψ production in p- Pb and pp collisions with the ALICE muon spectrometer. The J/Ψ production rate, and its mean transverse momentum, have been measured at forward and backward rapidities as a function of the charged particle multiplicity. Measurements of particle production as a function of the event multiplicity in small size systems provide a way to sign the presence of collective final state effects like those observed in Pb-Pb collisions. The observed increase of the J/Ψ production at backward rapidity with multiplicity, is consistent with that observed in pp collisions. However, a deviation from this behaviour in the J/Ψ production at forward rapidity at high multiplicity has been measured. A trend towards saturation has also been observed in the J/Ψ mean transverse momentum in p-Pb collisions. Whether these effects can be explained by cold nuclear matter effects or by the presence of further final state effects is still unresolved
BOKOBZA, PHILIPPE. "Infections neuromeningees a p. Acnes : a propos de 13 cas dont 9 porteurs de derivations de liquide cephalo-rachidien : etude des concentrations minimales inhibitrices de 8 antibiotiques sur ces souches". Reims, 1991. http://www.theses.fr/1991REIMMO97.
Testo completoSilveira, Lívia Teresa Ribeiro da [UNESP]. "Papel do resveratrol sobra a modulação do receptor Aril-hidrocarboneto (AhR) e o desenvolvimento da próstata de ratos expostos ao 2, 3, 7, 8-tetraclorodibenzo-p-dioxina (TDCC) durante a gestação". Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/132067.
Testo completoFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O TCDD (2,3,7,8-tetraclorodibenzo-p-dioxina), é considerado o contaminante ambiental com maior toxicidade na atualidade e sua ação está associada à interação com o receptor aril-hidrocarboneto (do termo inglês, AhR), responsável pela resposta biológica do TCDD sobre as células. Na próstata, o TCDD age diretamente no UGS inibindo o brotamento prostático através da ativação das vias dependentes de AhR. O Resveratrol destaca-se por suas propriedades anticâncer, antiagregação de plaquetas, antiinflamatória e antialérgica, atuando inclusive como antagonista do AhR. O estudo teve por objetivo avaliar o potencial quimioprotetor do Resveratrol sobre o desenvolvimento da próstata de ratos expostos ao TCDD durante a fase inicial da morfogênese prostática. Para isso, ratas prenhes da linhagem Wistar foram divididas em 4 grupos experimentais: Controle, TCDD, TCDD+Resveratrol e Resveratrol. O TCDD foi administrado em dose única no 15º. dia gestacional (DG15) na dose de 1μg/kg (diluído em óleo de milho) e o Resveratrol foi administrado entre o DG10 e o dia pós-natal 21 (DPN21) na dose de 20mg/kg (diluído em etanol 8%), ambos por via oral. Machos recém-nascidos (DPN1) foram eutanasiados para avaliação dos efeitos imediatos do TCDD (com ou sem a adição do Resveratrol) sobre a morfogênese prostática inicial, através de técnicas morfológicas e imunohistoquímicas, enquanto que, machos adultos (DPN90) foram eutanasiados para avaliação dos efeitos tardios. . No DPN1, os aspectos histológicos e morfométricos apontaram para a redução no número de brotos prostáticos no grupo TCDD quando comparado aos demais grupos Nesse mesmo grupo, as células epiteliais periféricas foram menos imunorreativas para p63 comparado com o Controle e TCDD+Resveratrol. O índice de proliferação celular nos brotos epiteliais e no mesênquima no grupo TCDD foi inferior ao observado nos grupos Controle e TCDD + Resveratrol, bem como o índice...
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is the most toxic environmental contaminant which mechanism of action is through the interaction with the aryl hydrocarbon receptor (AhR). In the prostate, TCDD works inhibiting the prostatic budding and activating the AhR-dependent pathways. Resveratrol is known by your anticancer, antiplatelet, anti-inflammatory and anti-allergic properties, besides acting as AhR antagonist. Therefore, the current research aimed to assess the protective effect of Resveratrol on prostate development in rats exposed to TCDD during early prostate morphogenesis. Pregnant Wistar rars were divided in four experimental groups: Control, TCDD. TCDD+Resveratrol and Resveratrol. TCDD (1μg/kg body weight) diluted in corn oil was administered by gavage as a single dose on 15th gestational day (GD15) while Resveratrol (20mg/kg body weight) was given by gavage (diluted in 8% of ethanol) between GD10 and postnatal day 21 (PND21). Newborn males (PND1) were euthanized to evaluate immediate effects of TCDD and Resveratrol on the initial prostatic morphogenesis, through morphological and immunohistochemical assays, while male rats (PND90) were euthanized for evaluation the late effects. There was decreasing of prostatic buds number in TCDD group. In the same group, basal cells showed weak immunoreactivity for p63 when compared to Control and TCDD+Resveratrol. TCDD reduced the cell proliferation index in the epithelial buds and mesenchyme as well as the number of androgen receptor (AR)-positive mesenchyme cells compared to Control and TCDD+Resveratrol groups. It is worth mentioning that the AR immunostaining was weak in the epithelial buds and intense in the surrounding mesenchyme in all experimental groups. On the other hand, α-actin staining was less intense in the differentiated mesenchymal cell that surrounded the epithelial buds in the TCDD group. Regarding to adult animals (PND90), the histological analysis revealed in ...
FAPESP: 2013/04401-0
Silveira, Lívia Teresa Ribeiro da. "Papel do resveratrol sobra a modulação do receptor Aril-hidrocarboneto (AhR) e o desenvolvimento da próstata de ratos expostos ao 2, 3, 7, 8-tetraclorodibenzo-p-dioxina (TDCC) durante a gestação /". Botucatu, 2015. http://hdl.handle.net/11449/132067.
Testo completoBanca: Patricia Simone Leite Vilamaior
Banca: Luis Fernando Barbisan
Resumo: O TCDD (2,3,7,8-tetraclorodibenzo-p-dioxina), é considerado o contaminante ambiental com maior toxicidade na atualidade e sua ação está associada à interação com o receptor aril-hidrocarboneto (do termo inglês, AhR), responsável pela resposta biológica do TCDD sobre as células. Na próstata, o TCDD age diretamente no UGS inibindo o brotamento prostático através da ativação das vias dependentes de AhR. O Resveratrol destaca-se por suas propriedades anticâncer, antiagregação de plaquetas, antiinflamatória e antialérgica, atuando inclusive como antagonista do AhR. O estudo teve por objetivo avaliar o potencial quimioprotetor do Resveratrol sobre o desenvolvimento da próstata de ratos expostos ao TCDD durante a fase inicial da morfogênese prostática. Para isso, ratas prenhes da linhagem Wistar foram divididas em 4 grupos experimentais: Controle, TCDD, TCDD+Resveratrol e Resveratrol. O TCDD foi administrado em dose única no 15º. dia gestacional (DG15) na dose de 1μg/kg (diluído em óleo de milho) e o Resveratrol foi administrado entre o DG10 e o dia pós-natal 21 (DPN21) na dose de 20mg/kg (diluído em etanol 8%), ambos por via oral. Machos recém-nascidos (DPN1) foram eutanasiados para avaliação dos efeitos imediatos do TCDD (com ou sem a adição do Resveratrol) sobre a morfogênese prostática inicial, através de técnicas morfológicas e imunohistoquímicas, enquanto que, machos adultos (DPN90) foram eutanasiados para avaliação dos efeitos tardios. . No DPN1, os aspectos histológicos e morfométricos apontaram para a redução no número de brotos prostáticos no grupo TCDD quando comparado aos demais grupos Nesse mesmo grupo, as células epiteliais periféricas foram menos imunorreativas para p63 comparado com o Controle e TCDD+Resveratrol. O índice de proliferação celular nos brotos epiteliais e no mesênquima no grupo TCDD foi inferior ao observado nos grupos Controle e TCDD + Resveratrol, bem como o índice...
Abstract: TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is the most toxic environmental contaminant which mechanism of action is through the interaction with the aryl hydrocarbon receptor (AhR). In the prostate, TCDD works inhibiting the prostatic budding and activating the AhR-dependent pathways. Resveratrol is known by your anticancer, antiplatelet, anti-inflammatory and anti-allergic properties, besides acting as AhR antagonist. Therefore, the current research aimed to assess the protective effect of Resveratrol on prostate development in rats exposed to TCDD during early prostate morphogenesis. Pregnant Wistar rars were divided in four experimental groups: Control, TCDD. TCDD+Resveratrol and Resveratrol. TCDD (1μg/kg body weight) diluted in corn oil was administered by gavage as a single dose on 15th gestational day (GD15) while Resveratrol (20mg/kg body weight) was given by gavage (diluted in 8% of ethanol) between GD10 and postnatal day 21 (PND21). Newborn males (PND1) were euthanized to evaluate immediate effects of TCDD and Resveratrol on the initial prostatic morphogenesis, through morphological and immunohistochemical assays, while male rats (PND90) were euthanized for evaluation the late effects. There was decreasing of prostatic buds number in TCDD group. In the same group, basal cells showed weak immunoreactivity for p63 when compared to Control and TCDD+Resveratrol. TCDD reduced the cell proliferation index in the epithelial buds and mesenchyme as well as the number of androgen receptor (AR)-positive mesenchyme cells compared to Control and TCDD+Resveratrol groups. It is worth mentioning that the AR immunostaining was weak in the epithelial buds and intense in the surrounding mesenchyme in all experimental groups. On the other hand, α-actin staining was less intense in the differentiated mesenchymal cell that surrounded the epithelial buds in the TCDD group. Regarding to adult animals (PND90), the histological analysis revealed in ...
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