Letteratura scientifica selezionata sul tema "668.402 86"

Abstract Background Imatinib mesylate (IM) at 400 mg/d remains a standard for first line therapy in patients (pts) with newly diagnosed chronic phase CML (CP-CML). A sub analysis of the IRIS study (Larson et al. Blood, 2008) demonstrated that pts with high IM trough levels achieved higher rates of major molecular response (MMR). The level of 1000 ng/ml was established as the [C]min value threshold to predict molecular response (Picard et al. Blood, 2007). We conducted a randomized trial to evaluate the value of IM dose optimization based on the monitoring of [C]min levels in newly diagnosed CP-CML pts (OPTIM-imatinib trial, EudraCT number 2008-006854-17). Patients and Methods Pts diagnosed with CP- CML for less than 3 months, not previously treated or treated with IM for less than 3 months were eligible and treated with IM 400 mg/d. IM [C]min was determined by chromatography-tandem mass-mass spectrometry 15 days after enrollment. Pts with a [C]min < 1000 ng/ml were randomized between a dose-increase strategy aiming to reach the threshold of 1000 ng/ml (arm A1) versus standard IM management (arm A2). Pts with [C]min levels ≥1000 ng/ml were observed (arm A3). All pts were managed according to the ELN 2009 recommendations (amended with ELN 2013 recommendations). IM [C]min levels were assessed monthly in A1 and A2 and every 3 months in A3. BCR-ABLIS was assessed every 3 months. The primary end-point was MMR rates at 12 months. Results One hundred thirty nine pts were enrolled. Median follow-up was 31 months. Median age was 64y (25 to 88y), sex ratio (M/F) was 1.4 and Sokal score distribution was 21%, 41% and 38% for high, intermediate and low categories respectively, equally distributed in the 3 arms. In 6 pts the initial [C]min was not assessed (3 were intolerant and 3 declined the dosage). Thus 133 pts were studied. In 86 pts (65%), initial [C]min value was < 1000 ng/ml. These pts were randomized between A1 (43 pts) and A2 (43 pts). [C]min was ≥1000 ng/ml in the 47 remaining pts followed in A3. Table 1 shows the significant improvement of the median IM [C]min after dose adjustment in A1 (p<0.0001) as compared to standard management in A2. Correspondingly, IM daily dose increased in A1 (p<0.0001) to reach a mean value of 600 mg/d. In the experimental A1 arm, the distribution of IM doses at 12 months was 13% for 500 mg/d, 30% for 600 mg/d, 34% for 800 mg/d whereas 16% of the pts remained at 400 mg/d and 7% were dose decreased at 300 mg/d. During follow-up, a similar proportion of pts with AE was observed in A1 (58%) and A2 (51%). Eight SAE related to IM were equally distributed in A1, A2 and A3. Cumulative incidences of treatment discontinuation were comparable in the 3 arms (overall, 18.8% by 12 months and 34.1% by 24 months). Reasons for discontinuation were not similar in A1 and A2 with a trend for more treatment failures in A2 as compared to A1 (60% versus 18%, p=0.08). At 12 months, MMR was achieved in 27 out of 43 pts (63%; 95%CI 49-77) in A1 as compared to 16 out 43 pts (37%; 95%CI 23-51) in A2 (p=0,031). The rates of MMR were not statistically different between A1 and A3 (p=0.12). Conclusions Only 1/3 of pts on IM400 were correctly dosed and may not require systematic high dose IM. Two-thirds of the pts were not exposed enough to IM at standard dose and may benefit from individualized strategies. A tailored dose adjustment based on pharmacology resulted in higher MMR rate at 12 months (63% vs 37%), a magnitude in line with the results previously reported with second generation tyrosine kinase inhibitors or high dose IM front line. Our results may provide a strong rational to early personalize the use of IM and IM generic formulations in order to optimize the outcome for each patient. This study was supported by a grant from the French Department of Health (Programme Hospitalier de Recherche Clinique). Table 1. Median [C]min (ng/ml; (95% CI)) Initial Assessment M3 M6 M9 M12 A1 591; (508-654) 838; (746-922) 1001; (748-1261) 1062; (918-1221) 1013; (830-1277) A2 651; (558-797) 605; (487-786) 591; (517-722) 605; (460-720) 646; (576-894) A3 1314; (1199-1514) 1032; (899-1143) 1002; (784-1205) 935; (737-1073) 1000; (846-1098) Mean IM daily dose (mg/d; (95% CI)) Inclusion M3 M6 M9 M12 A1 400 538; (508-568) 611; (563-658) 607; (545-668) 600; (535-665) A2 400 395; (387-402) 392; (383-401) 391; (381-401) 391; (381-401) A3 400 400; (400-400) 398; (385-410) 389; (376-402) 382; (370-395) Disclosures Rousselot: BMS: Consultancy, Speakers Bureau; Novartis: Speakers Bureau; Pfizer: Consultancy. Johnson-Ansah:BMS: Speakers Bureau; Hybrigenics SA: Consultancy, Research Funding; Novartis: Consultancy, Speakers Bureau. Huguet:PFIZER: Consultancy, Speakers Bureau; ARIAD: Consultancy, Speakers Bureau; BMS: Consultancy, Speakers Bureau; Novartis: Consultancy, Research Funding. Legros:Novartis: Research Funding, Speakers Bureau; ARIAD: Speakers Bureau; BMS: Speakers Bureau. Gardembas:Novartis: Speakers Bureau. Coiteux:ARIAD: Speakers Bureau; BMS: Speakers Bureau; Novartis: Speakers Bureau. Deau:BMS: Honoraria. Mahon:ARIAD: Consultancy; Pfizer: Consultancy; Bristol-Myers Squibb: Consultancy, Honoraria; Novartis: Consultancy, Honoraria.

Section 404 of the Sarbanes-Oxley Act and Auditing Standard No. 2 (PCAOB 2004) require management and the auditor to report on internal controls over financial reporting. Section 404 is arguably the most controversial element of SOX, and much of the debate around the costs of implementing section 404 has focused on auditors' fees (Ernst & Young 2005). In this paper, we examine the association between audit fees and internal control disclosures made pursuant to section 404. Our sample includes 660 manufacturing firms that have a December 31, 2004 fiscal year-end and filed the section 404 report by May 15, 2005. We find that the mean (median) audit fees for the firms in our sample for fiscal 2004 is 86 (128) percent higher than the corresponding fees for fiscal 2003. Audit fees for fiscal 2004 are 43 percent higher for clients with a material weakness disclosure compared to clients without such disclosure; however, audit fees for fiscal 2003 are not associated with an internal control material weakness disclosure (in the 10-K filed following fiscal 2004). We also find that the association between audit fees and the presence of a material weakness disclosure does not vary depending on the type of material weakness (systemic or non-systemic).

Introduction. Foreign body aspiration (FBA) into the respiratory tract is a severe, life-threatening condition in children which requires urgent medical and diagnostic measures. Purpose. To study outcomes after FBA diagnostics and treatment in children and to develop an algorithm for diagnosing foreign bodies in the respiratory tract in this group of patients. Material and methods. Outcomes in 86 children who were hospitalized with suspected foreign bodies in their respiratory tract to the Clinic of Pediatric Surgery in Marat Ospanov West Kazakhstan Medical University, Aktobe, Republic of Kazakhstan in 2018–2022. Results. In 73 children, out of 86, FBA was confirmed. Distribution of children with FBA by age was as follows: less than one year – 5 (6.8 %) children; 1–3 years – 46 (63.1 %); 3–5 years – 7 (9.6 %), over 5 years – 15 (20.5 %). Localization of foreign bodies in the respiratory tract was as follows: larynx –6; trachea – 10, right main bronchus –26, left main bronchus – 30, both lower lobe bronchi – 1. The revealed foreign bodied were : peanuts – 24 (32.8 %) cases, sunflower seed – 13 (17.8 %), fountain pen cap – 7 (9.6 %), plastic toy part – 5 (6.8 %), fish bone – 5 (6.8 %), stationery carnation – 4 (5.5 %), bone – 4 (5.5 %), small rock – 4 (5.5 %), carrot – 3 (4.2 %), tooth – 2 (2.7 %), bead – 1 (1.4 %), food masses –1 (1.4 %). In the diagnostics of foreign bodies, anamnesis, clinical examination, radiation and endoscopic diagnostic techniques were of great importance. On analyzing the obtained clinical material, the researchers developed their own algorithm for FBA diagnosis. Foreign bodies were removed with rigid bronchoscopy in 55 children, with fibrobronchoscopy in 9 children, direct laryngoscopy – in 6 cases, at thoracotomy and bronchotomy – in 3 children. There were no complications associated with the removal of foreign bodies. Conclusions. Foreign bodies in the respiratory tract are met most often in children , aged 1–3. In doubtful cases, MSCT was used in addition to traditional diagnostic methods. It allows to exclude or identify foreign bodies invisible at X-ray images. FBA removal should be performed at the third level medical institutions.

El objetivo de este estudio es evaluar el crecimiento inicial de la caña de azúcar variedad RB 86-7515, cultivada en sistema de producción orgánica y fertilizada con dosis de lithothanmium y vinaza, se desarrolló un experimento. La investigación se llevó a cabo en la Escuela de Agronomía de la Universidade Federal de Goiás, Brasil. El delineamiento estadístico fue en un diseño completamente aleatorio con tres repeticiones, en esquema factorial (5 x 5 x 2). Las plantas fueron cultivadas en contenedores de plástico de 200 litros. Los tratamientos correspondieron a cinco dosis de vinaza (0, 165, 330, 495 e 660 m3.h-1) y cinco dosis de lithothanmium (0, 100, 200, 300 e 400 kg.ha-1) en dos ambientes: irrigado y no irrigado. El sistema de irrigación utilizado fue por goteo con emisores de 4 L.h-1. La aplicación de los tratamientos de fertilización, fueron divididas de acuerdo con la marcha de absorción de nutrientes por las plantas de caña de azúcar. Se evaluaron número de brotes (cañas), altura de plantas, índice de área foliar y diámetro del cormo a lo largo de diferentes etapas fenológicas del cultivo. Los tratamientos aplicados provocaron efectos significativos sobre los parámetros de crecimiento del cultivo, siendo las plantas irrigadas y fertilizadas con 196 kg.ha-1 de lithothanmium y 330 m3.ha-1 de vinaza, las que exhibieron los mejores resultados.

LITHOTHAMNIUM E VINHAÇA NA PRODUÇÃO DE CANA-DE-AÇÚCAR ORGÂNICA IRRIGADA E DE SEQUEIRO WALTER DANILO MARADIAGA RODRIGUEZ1; ADÃO WAGNER PÊGO EVANGELISTA1; JOSÉ ALVES JÚNIOR1; WILSON MOZENA LEANDRO1; MARCUS VINICIUS HONORATO DOMINGOS1 E DERBLAI CASAROLI1 ¹Núcleo de Pesquisa em Clima e Recursos Hídricos do Cerrado – Escola de Agronomia - Universidade Federal de Goiás, Rodovia Goiânia / Nova Veneza, Km 0, Goiânia, Goiás, CEP: 74690-900, E-mail: maradiagawd@gmail.com, awpego@bol.com.br, josealvesufg@yahoo.com.br, wilsonufg@gmail.com, derblaicasaroli@yahoo.com.br, marcus-domingos@hotmail.com 1 RESUMO Com o objetivo de avaliar a influência do lithothamnium e vinhaça na produtividade e as características tecnológicas da cana-planta variedade RB 86-7515 cultivada em sistema de produção orgânica, conduziu-se um experimento na Universidade Federal de Goiás. O delineamento estatístico utilizado foi inteiramente casualizado com 3 repetições em esquema fatorial (5x5x2). As plantas foram cultivadas no interior de tambores de 200 litros. Os tratamentos corresponderam a cinco doses de vinhaça (0, 165, 330, 495 e 660 m3 ha-1) e cinco doses de lithothamnium (0, 100, 200, 300 e 400 kg ha-1) e cultivo em regime irrigado e de sequeiro. O sistema de irrigação utilizado foi por gotejamento com emissores com vazão de 4 L h-1. Avaliaram-se: produtividade do colmo (t ha-1), teor de sólidos solúveis (Brix %), porcentagem de umidade do colmo, teor de sacarose aparente na cana (Pol %), teor de fibra (Fibra %), pureza do caldo e açúcar total recuperável (ATR) expresso em kg t ha-1. Os tratamentos aplicados produziram efeitos significativos sobre a produtividade e características tecnológicas da cultura, sendo as plantas irrigadas e adubadas com 200 kg ha-1 de lithothamnium e 330 m3 ha-1 de vinhaça as que apresentaram os melhores resultados. Palavras-chaves: Saccharum sp., adubação, irrigação. MARADIAGA-RODRIGUEZ, W. D.; EVANGELISTA, A. W.; ALVES JÚNIOR, J.; MOZENA, W.; DOMINGOS, M. V. H.; CASAROLI D. LITHOTHAMNIUM AND VINASSE IN THE PRODUCTION OF ORGANIC SUGAR CANE IRRIGATED AND UNIRRIGATED 2 ABSTRACT The objective of this study was to evaluate the productivity and technological characteristics of sugarcane, variety RB 86-7515. The experiment was carried out in the experimental area of the School of Agronomy, of the Federal University of Goiás. A completely randomized experimental design (CRD) was applied, with three replicates, in a 5x5x2 factorial scheme. The plants were grown in containers of 200 liters. The treatments were five vinasse doses (0, 165, 330, 495 and 660 m3 h-1) and five doses of lithothamnium (0, 100, 200, 300 and 400 kg ha-1) and cultivation under irrigated and unirrigated. The irrigation system used was drip emitters with flow rate of 4 L h-1. The variables evaluated were fiber % cane; Brix % juice; pol % cane; juice purity and total recoverable sugar - TRS and productivity per hectare. The treatments produced significant effects on the parameters of crop growth, and irrigated plants, fertilized with 200 kg ha-1lithothamnium and 330 m3 ha-1 of vinasse showed the best results. Keywords: Saccharum sp., fertilization, irrigation.

Spinel cobalt oxide or Co3O4, has been proven to be a promising material as bifunctional electrocatalyst for ORR/OER. In this study, we show further improvement of the electrocatalytic activity via metal doping. Metal-doped Co3O4 was synthesized using a simple hydrothermal method at 120° C for 24 h, followed by calcination at 400° C for 1 h. A surfactant was used to control the morphology of the sample such that either 1D or 2D structure was obtained. The 2D structure shows better electrical conductivity with Rct of 70 Ohm vs. 86 Ohm for the 1D structure. Electrochemical test show that the 2D structure gives a ∆E of 870 mV vs. 949 mV for the 1D structure, due to primarily the excellent ORR activity of the 2D structure, i.e., E-3 = 711 mV for the 2D structure vs. E-3 = 667 mV for the 1D structure. The use of the 2D structure in zinc air battery is also demonstrated.

593 Background: Cancer stem cells or stemness-high cancer cells are considered to be fundamentally important for resistance to therapy, recurrence and metastasis. Napabucasin, a first-in-class cancer stemness inhibitor in clinical development, suppresses cancer stemness by targeting Stat3-driven gene transcription. Preclinical studies suggest that napabucasin sensitizes heterogeneous cancer cells to chemotherapeutics and targeted agents. Methods: This study was performed to assess signs of anti-tumor activity of napabucasin in combination with FOLFIRI +/- Bev in CRC pts. Napabucasin was administered at 240 mg BID. FOLFIRI (5-FU 400 mg/m2 bolus with 2400 mg/m2, irinotecan 180 mg/m2, and leucovorin 400 mg/m2 infusion) +/- Bev 5 mg/kg was administered biweekly until disease progression or other discontinuation criterion. pSTAT3 status of archival tumor tissue was assayed by immunohistochemistry using the H-score with pSTAT3highdefined as ≥ 5% pSTAT3+ cancer cells and tumor stroma staining at ≥ 2+ intensity. Results: 63 CRC pts with an average of >2 prior therapy lines were enrolled. No pharmacokinetic interactions or dose-limiting toxicity was observed. Most common adverse events (AEs) included grade 1/2 diarrhea, nausea, vomiting and fatigue. 25 pts had grade 3 AEs, including diarrhea (14), fatigue (4), dehydration (2), electrolyte imbalance (4), nausea (1) and weight loss (1) resolved with dose reduction and supportive care. Among 63 pts enrolled who received RECIST evaluation, disease control (CR+PR+SD) was observed in 49 pts (86%) with an overall response (CR+PR) of 28% with 1 pt achieving CR. Clinical trial information: NCT02024607. Conclusions: This phase Ib/II study suggests napabucasin may sensitize chemorefractory CRC to FOLFIRI +/- Bev. Encouraging signs of synergistic activity between napabucasin and FOLFIRI was observed in CRC pts regardless of pSTAT3 status.[Table: see text]

Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissue, ACE2 was most abundant in testis and corpus luteum, kidney, small intestine and capillaries of selected organs. At least an occasional weak ACE2 positivity of tumour cells was seen in 83 of 119 (70%) tumour types. ACE2 tumour cell positivity was particularly frequent in papillary (94%) and clear cell (86%) renal cell carcinoma, colorectal adenocarcinoma (81%), mucinous ovarian cancer (61%), cholangiocarcinoma (58%), hepatocellular carcinoma (56%), and in adenocarcinomas of the stomach (47%), pancreas (42%), and the lung (35%). ACE2-positive capillaries were found in 409/12,644 (3%) of analysable tumours, most frequently in tumours with endocrine/neuroendocrine activity. Presence of ACE2-positive capillaries was linked to low stage in papillary thyroid cancer and low grade in neuroendocrine neoplasms. In conclusion, ACE2 expression can occur both in tumour cells and tumour-associated capillaries in a broad variety of different tumour types at highly variable frequencies.

The Ogoki-North Nakina Forests consist of (10 638 km2) unroaded boreal forest approximately 400 km northeast of Thunder Bay, Ontario (lat 50&deg;- 51&deg;31'N, long 86&deg;30'- 89&deg;W). Woodland caribou (Rangifer tarandus caribou) inhabit discrete portions within these forests based on minimal current and past historical data. As part of the Forest Management Planning process, for the period 1997-2097, a woodland caribou habitat mosaic has been developed to coordinate present and future forest management activities with the retention and development of current and future woodland caribou habitat. Several criteria including, past fire history, forest structure, age, species composition, proximity to current road access and location of existing and potential caribou habitat, helped identify and delineate 50 mosaic harvest blocks. Each harvest block will be logged in one of five 20 year periods over a 100 year rotation (1997&not;2097). The harvest blocks have been developed to simulate a pattern of past wildfire history in an area that has not been subjected to past forest management activities, while managing for woodland caribou, a locally featured species.

In situ net N mineralization and net nitrification rates were measured in organic forest floor (LFH) and mineral horizons of mature and logged trembling aspen (Populus tremuloides Michx.) stands on the Boreal Plain in western Canada. Cumulative May to September mineralization for mature and logged plots was 1354 ± 534 and 1631 ± 1584 mg N·m–2, respectively, in the LFH horizon and 810 ± 394 and –305 ± 3957 mg N·m–2, respectively, in the mineral horizon. Net nitrification in mature and logged plots was 86 ± 142 and 658 ± 435 mg NO3-N·m–2, respectively, in the LFH horizon and 67 ± 50 and 409 ± 325 mg NO3-N·m–2, respectively, in the mineral horizon. Monthly mean NH4-N concentrations in the LFH tended to be higher in logged plots than in mature plots. Winter net N mineralization and nitrification rates in the LFH of mature plots were up to 7% and 11% of growing season net rates, respectively. In comparison, these rates in logged plots were up to 127% and 59% of the growing season net rates, respectively, indicating that winter activity may make a large contribution to annual net mineralization and nitrification after logging.

Abstract Manuscripts dated certainly or possib y before 1261 H Jerusalem, Patriarchike Bibliotheke 36. Turyn 86–7, Matthiessen 41-2, Mastronarde 2. Facsimile: S. G. Daitz, The Jerusalem Palimpsest of Euripides. A Facsimile Edition with Commenta y (1970). Scholia (and corrigenda to the preceding work): S. G. Daitz, The Scholia in the Jerusalem Palimpsest of Euripides. A critical Edition (1979). A collation, made from photographs, was published by J. A. Spranger, CQ32 (1938) 200–2 10th–11th century. Lines 105–213, 313–412, 564–614, 716–66, 897–946, II52–1200, 1356–1556. Collated from the facsimile.

В рамках отечественных исследований закономерностей формирования и распространения растительного покрова и оптимизации способов его использования на урбанизированных территориях наблюдается рост актуальности изучения малых и средних городов. В результате анализа порядка 60 публикаций и статистических материалов за период с 2010 по 2022 гг., представленных в российских электронных научных библиотеках Elibrary, ResearchGate, Google Scholar, обсуждаемые сегодня вопросы изучения растительного покрова, рассматриваемой категории городов России были объединены в несколько направлений: Видовое богатство урбанофлоры и ее структуры. За указанный период найдено и проанализировано 50 публикаций и статистических материалов, в которых отражены полные списки видов урбанофлоры для 86 городов (18 малых и 68 средних). Видовое богатство колеблется от 140 (г. Анива, Сахалинская область) до 786 (г. Ливны, Орловская область). В 6 городах отмечено до 200 видов растений, в 37 – от 201 до 400, в 27 – от 401 до 600 и только в 12 зарегистрировано свыше 600 видов [3]. Как отмечают специалисты, разница в количестве зависит от многих факторов: площади и численности населения города, возраста населенного пункта, природно-климатических условий и др. [1, 5, 6]. Однако нами не выявлено тесных корреляционных связей между факторами. В структуре урбанофлоры преобладают семейства: Asteraceae, Poaceae, Rosaceae, Fabaceae, Brassiaceae, Cyperaceae, Сaryophyllaceae, Apiaceae, Polygonaceae, Ranuncllaceae [3]. Аборигенная и адвентивная (чужеродная) фракция урбанофлоры. В анализируемых научных публикациях отмечено, что в среднем на долю аборигенной и адвентивной фракции приходится 71% (317 видов) и 29% (130) соответственно. В урбанофлоре 7 городов отмечается до 200 аборигенных видов, в 37 – от 201 до 400 и в 8 городах свыше 400. Что касается адвентивных, то в 42 городах отмечено не больше 200 видов и только в 5 – от 201 до 400. В связи с тем, что в некоторых городах процесс адвентизации достигает 40-50%, актуальным является организация охраны аборигенных, в том числе редких и охраняемых видов. Это связано с их приспособленностью к внешней среде, а также они поддерживают устойчивость биоразнообразия [3]. Охрана урбанофлоры. В урбанофлоре малых и средних городов - Абазы (Республика Хакасия) 8 видов занесены в Красную книгу (6 – Красная книга России и 2 – региональная), Кинешма (Ивановская область) 2 вида в региональной Красной книге, Кумертау (Республика Башкортостан) 11 видов занесено в Красную книгу России, Мелеуз (Республика Башкортостан) 10 видов и другие. В некоторых городах отмечены редкие и охраняемые виды: Гаврилов Посад (Ивановская область) 24 вида, Кадников (Вологодская область) 74 вида отнесены к статусу «редкие», 34 – «охраняемые» и для 40 видов необходим ботанический контроль, Сенгилей (Ульяновская область) – 19 редких видов и другие. В настоящее время в городах активно организуется сеть ООПТ различного типа (памятники природы, ботанические сады, дендрарии, парки и другие). Однако большинство публикаций по данному направлению касается больших и крупных городов. Отмечено всего 4 средних города, имеющих ООПТ – Туапсе и Геленджик (Краснодарский край), Биробиджан (ЕАО), Магадан (Магаданская область) [4, 6].

Introduction: Guillain-Barré syndrome is an acute/subacute set of clinical features of immune mediated polyradiculoneuropathy, typically after respiratory or gastrointestinal viral infection. In this scenario, we described a case of the syndrome mentioned after infection by sars-cov-2 virus. Objectives and Methods: Description of a clinical case after analysis of medical history and complementary exams, in addition to literature review. Design and Setting: Case report, type of descriptive study, developed in the Institute of Medical Assistance to the State Public Servant of São Paulo. Results: A 68-year-old female patient with clinical and laboratory diagnosis of coronavirus infection, hospitalized in need of oxygen supplementation, which evolved after twelve days of symptoms with hypoesthesia on legs and feet and progressively ascending and symmetrical flaccid paraparesis that led to tetraparesis. Neurological examination showed tetraparesis (muscle strength: grade III in MMSS and grade II in MMII), hyporeflexia in MMSS and reflexes abolished in the lower limbs, plantar skin reflex in flexion in both feet, preserved facial mimicry. About complementary tests, it presented cerebrospinal fluid with albuminocytologic dissociation (cell: 1, protein: 89, glucose: 86), RT-PCR for sars-cov-2 research in cerebrospinal fluid, inconclusive, in addition to four-limb electroneuromyography performed after 19 days of onset of neurological condition, indicated polyradiculoneuropathy with involvement of sensory and motor fibers, primarily demyering. Treatment with human immunoglobulin 400 mg/kg/day for 05 days was started. The reported patient was dismissed from the hospital with significant improvement, presenting muscle strength: grade V in MMSS and grade IV in MMII and already with the ability to walk. Conclusions: the case describes a classic neurological complication associated with a virus that was once non-circulating, but currently with a big clinical relevance.