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Dumond, Mark, David Dumond, Cheryl Cook, Brett Duffner e Julie Laribee. "A Clinical Evaluation of the Correlation and Reprodicibility Of Three Automated Devices For Measurement of Activated Clotting Times". Journal of ExtraCorporeal Technology 22 (1990): 27–29. http://dx.doi.org/10.1051/ject/199022s027.
Abstract (sommario):
The Activated Clotting Time (ACT) assumes an important role in documentation of adequacy of perfusion. Therefore, it is important to document the correlation and reproducibility of automated systems currently available to measure the ACT value. During surgical procedures of 37 patients requiring cardiopulmonary bypass a blood sample was drawn in a single syringe and ACT values obtained using four Hemotec ACTs (T-ACT), four Hemochron ACTs (M-ACT), and two Sonoclot ACTs (S-ACT). Sample points with the mean of two of the three sets of ACTs exceeding 650 were excluded and the values were divided into heparinized (ACTH) (n=44) and nonheparinized (ACTN) (n=58) groups. Group Mean Value Avg. Std. Dev. r 2/T-ACTN r w/H-ACTN r w/T-ACTH r w/H-ACTH T-ACTN 104 3 - .638 - - H-ACTN 128 5 .638 - - - S-ACTN 138 11 .663 .580 - - T-ACTH 551 48 - - - .224 M-ACTH 514 69 - - .224 - S-ACTH 768 98 - - .041 .244 The very poor correlation of the three systems raises doubts as to interchangeability of ACT values from each system. The reproducibility (based on the size of the STD. DEV.) of the Hemotec system is significantly better than the Sonoclot.
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Barr, Emma, Judith Neubauer e Celine Gelinas. "516 LinkedIn Marketing Strategies to Drive NJ ACTS Regulatory Core Engagement". Journal of Clinical and Translational Science 6, s1 (aprile 2022): 106. http://dx.doi.org/10.1017/cts.2022.310.
Abstract (sommario):
OBJECTIVES/GOALS: Our purpose is to promote traffic toward the NJ ACTS Regulatory Cores recently launched website and increase investigator engagement through marketing strategies on LinkedIn. Landscaping to characterize the profiles of researchers on LinkedIn was also completed to estimate the feasibility of engaging with a target population on LinkedIn. METHODS/STUDY POPULATION: Insight gathering was performed to analyze what percentage of researchers possessed a LinkedIn profile and actively used their accounts. A sample population consisting of 284 NJ ACTS members were analyzed to summarize the type of researchers on LinkedIn, and their likelihood of responding to LinkedIn marketing campaigns. Efforts to launch a company LinkedIn page and collect followers were completed. Different methods of promotion were evaluated, including direct vs. mass email outreach to over 600+ researchers at Rutgers. Effectiveness of our platform was measured by comparing/overlaying Regulatory website traffic with LinkedIn traffic, as well as tracking the metrics of LinkedIn posts. RESULTS/ANTICIPATED RESULTS: Among 284 NJ ACTS members, 76% (n=215) possess a LinkedIn profile, but only 21% (n=59) are actively interacting with material on LinkedIn, such as creating, commenting, or sharing posts. Among the NJ ACTS LinkedIn users, 27% of individuals (n=57/215) responded to a direct outreach. Retention of the created organizational page was strong, as most users who visited the Regulatory Core page were likely to become followers. Massive email outreach to 600+ researchers within RBHS did not yield a strong LinkedIn following, however it did result in strong signals of website traffic during the days after the promotion was sent. Engagement with posts on LinkedIn can also be amplified and messaging proliferated when colleagues reshare Regulatory posts on their personal feeds. DISCUSSION/SIGNIFICANCE: 3/4 of academic researchers are likely to be on LinkedIn but may not be active users of the platform. The most effective outreach is through direct messaging as opposed to broader, less individualized tactics (including mass email outreach). Evidence suggests potential to utilize LinkedIn to proactively engage in regulatory-related activities.
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Sljivo, Armin, Lejla Brigic, Arian Abdulkhaliq, Ilma Dadic, Leopold Reiter, Iman Sirucic, Mohammed Abdulkadir e Ahmed Mulac. "Echocardiographic Findings of Covid-19 Patients in Canton Sarajevo During the Third Wave of the Covid-19 Pandemic". Materia Socio Medica 35, n. 4 (2023): 290. http://dx.doi.org/10.5455/msm.2023.35.290-294.
Abstract (sommario):
Background: Increasing evidence indicates that COVID-19 may result in cardiac issues in certain individuals, such as myocarditis, arrhythmias, and heart failure. Ongoing research on echocardiographic manifestations is still limited.Objective: To investigate the incidence and patterns of left and right ventricular dysfunction in COVID-19 patients. Methods: This study retrospectively observed COVID-19 patients admitted to the Clinical Center of University of Sarajevo during the third wave, with a particular focus on cardiac evaluations.Results. Our patients, predominantely male 155 (72.4%), with a mean age of 66.2±11.4, having hypertension 86 (40.1%), diabetes mellitus 61 (28.5%), hyperlipidemia 144 (67.3%), were active smokers 87 (40.6%), had family history of cardiovascular diseases 123 (57.5%) and were COVID-19 positive 95 (44.4%), presented because of chest pain 78 (36.4%), dyspnea 103 (48.1%), palpitations 67 (31.3%), fatigue 106 (49.5%) and peripheral oedema 30 (14.0%). COVID-19 patients reported much higher symptoms of dyspnea (65 (68.4%) vs 38 (31.9%)) and fatigue (73 (76.8%) vs 33 (27.7%)) than COVID-19 negative patients. On the initial laboratory report, COVID-19 patients had a significantly (p<0.05) higher mean score of C-reactive protein (24.0±4.8 vs. 6.0±2.1), D-dimer (1.6±2.5 vs 0.8±0.6), ALT (94.8±17.2 vs 36.5±19.9) and creatinine (128.0±80.8 vs. 93.4±40.1) when compared to COVID-19 negative patients. COVID-19 patients had enlarged left atrium diametes (31.6±5.6 vs 27.5±5.3), enlarged left ventricular diameter both in systole (27.9±18.1 vs 23.3±16.3) and diastole (39.3±24.1 vs 34.9±22.7), reduced left ventricular ejection fraction (53.5±9.2 vs 59.8±4.3) and elevated right ventricular systolic pressure (37.0±16.4 vs 35.1±8.6). Conclusion. COVID-19 patients had enlarged left atrium, enlarged systolic and diastolic left ventricular diameter, reduced left ventricular ejection fraction and elevated right ventricular systolic pressure.
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Carretero, M. V., e F. de A. F. de Mello. "Produção de latex por clones de seringueira (Hevea spp) no planalto e litoral do Estado de São Paulo". Anais da Escola Superior de Agricultura Luiz de Queiroz 45 (1988): 151–66. http://dx.doi.org/10.1590/s0071-12761988000100011.
Abstract (sommario):
A partir dos dados de produção em volume de látex, extraído de clones de seringueira (Hevea spp.), durante 17 anos no Centro Experimental Theodureto de Camargo (Campinas, região de planalto) e 16 anos na Estação Experimental Vale do Ribeira (Pariquera-Açú, região litorânea), ambos pertencentes ao Instituto Agro_ nômico do Estado de São Paulo, Campinas, foi estudado o comportamento da produção de cada clone. Pelo teste de Tukey foi possível determinar, considerando-se as duas regiões, os melhores clones quanto ao potencial produtivo dado pelas médias de produção. Entre os melhores encontram-se: RRIM 600 e BSA 20. 0 primeiro pertence a Estação Experimental e o segundo ao Centro Experimental. Em seguida tem-se um grupo intermediário, formado pelos clones CA 1328, Tjir 16, C 228, RRIm 526, C 297, LCB 510 e Fx 25, todos pertencentes ao Centro Experimental. Os menos produtivos foram: Fx 25, C 290 e RRIM 600, todos pertencentes ao Centro Experimental. 0 clone Fx 25 apresentou baixa produção nas regiões estudadas, porém sua produção na Estação Experimental foi superior à do Centro Experimental, bem como às dos clones C 290 e RRIM 600, cultivados no Centro Experimental.
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Poole, S. G., M. J. Dooley e D. Rischin. "Calculating carboplatin doses using the 4-variable modification of diet in renal disease (4-v MDRD) estimate of glomerular filtration rate (GFR) in the Calvert formula". Journal of Clinical Oncology 25, n. 18_suppl (20 giugno 2007): 2521. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.2521.
Abstract (sommario):
2521 Background: The dose of carboplatin is usually calculated using the Calvert formula, with various bedside estimates utilized rather than directly measured GFR. The 4-v MDRD equation (Levey AS, et al. Ann Intern Med 2006; 145: 247–254) is now advocated as the routine method of estimating renal function from serum creatinine in all patients. Adoption in clinical practice is occurring despite lack of validation in oncology patients. The aim of this study was to compare carboplatin doses derived from the Calvert formula using measured GFR and the estimates of the 4-v MDRD equation and other established estimates. Methods: GFR was determined using technetium-99m diethyl triamine penta-acetic acid (Tc99mDTPA) clearance. Serum creatinine (Jaffe method) was measured and GFR estimates calculated using 4-v MDRD, Cockcroft and Gault formula (CGF), Wright, Martin, and Jelliffe (JF) formulae. Carboplatin doses were calculated using the Calvert formula, targeting an area under the curve of 7mg.ml- 1.min-1. Results: GFR was measured in 510 adult oncology patients (323 male, 187 female, mean age 63 years, range 17–87 years, mean GFR 84 mL/min, range 16–205 mL/min). The mean (range) carboplatin dose was 765 mg (287–1,610 mg), 681 mg (237–1,306 mg), 674 mg (249–2,044 mg), 721 mg (261–1,536mg), 741 mg (261–2,128mg), 620 mg (244- 1,329 mg) for measured GFR, 4-v MDRD, CGF, Wright, Martin, and JF formulas respectively. The accuracy (% within 20% of ‘true’ dose) was 58%, 63%, 73%, 72% and 49% for 4-v MDRD, CGF, Wright, Martin, and JF formulas respectively. Carboplatin doses derived using the 4-v MDRD estimate of GFR become increasingly less accurate with increasing GFR (see table ). All other formulas performed similarly. Conclusions: The 4-v MDRD equation resulted in an imprecise estimation of carboplatin doses with the degree of variability dependant on the level of renal function. [Table: see text] No significant financial relationships to disclose.
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Afroz, M., MR Amin, MRU Miah e MM Hossain. "Incidence of major insect pests on sweet gourd germplasm". Bangladesh Journal of Agricultural Research 44, n. 4 (1 marzo 2020): 621–30. http://dx.doi.org/10.3329/bjar.v44i4.45697.
Abstract (sommario):
Abundance of the major insect pests viz., red pumpkin beetle, epilachna beetle and fruit fly on twelve sweet gourd germplasms namely BD 264, BD 265, BD 266, BD 268, BD 269, BD 274, BD 275, BD 277, BARI Mistikumra 1, BARI Mistikumra 2, Gazipur Local Line and China line was studied in the experimental field of the Department of Entomology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh during July 2018 to June 2019. The mean number of red pumpkin was the highest (2.3 adults/ 3 leaves) during 4th week of December and the lowest (0.7 adults/ 3 leaves) during 4th week of March. The mean number of grub (6.5 grubs/3 leaves) and adult (2.3 adults/ 3 leaves) of epilachna beetle were the highest during 2nd week of March and 4th week of February, respectively. The mean number of fruit fly was found the lowest (1.0 adults plant-1) during 5th week of January and the highest (2.5 adults plant-1) during 4th week of February. BARI Mistikumra 1, BARI Mistikumra 2 and China Line provided the lowest yield ranged from 4.8 ± 5.3 to 7.4 ± 0.5 t ha-1 and the remaining germplasms showed statistically similar yield.
Bangladesh J. Agril. Res. 44(4): 621-630, December 2019
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Oleg Kshivets. "Non-small cell lung cancer: 10-year survival after surgery". World Journal of Advanced Research and Reviews 12, n. 2 (30 novembre 2021): 246–60. http://dx.doi.org/10.30574/wjarr.2021.12.2.0586.
Abstract (sommario):
Objective: 10-Year survival (10YS) after radical surgery for non-small cell lung cancer (LC) patients (LCP) (T1-4N0-2M0) was analyzed. Methods: We analyzed data of 768 consecutive LCP (age=57.6±8.3 years; tumor size=4.1±2.4 cm) radically operated (R0) and monitored in 1985-2021 (m=660, f=108; upper lobectomies=277, lower lobectomies=177, middle lobectomies=18, bilobectomies=42, pneumonectomies=254, mediastinal lymph node dissection=768; combined procedures with resection of trachea, carina, atrium, aorta, VCS, vena azygos, pericardium, liver, diaphragm, ribs, esophagus=193; only surgery-S=618, adjuvant chemoimmunoradiotherapy-AT=150: CAV/gemzar + cisplatin + thymalin/taktivin + radiotherapy 45-50Gy; T1=320, T2=255, T3=133, T4=60; N0=516, N1=131, N2=121, M0=768; G1=194, G2=243, G3=331; squamous=417, adenocarcinoma=301, large cell=50; early LC=214, invasive LC=554; right LC=412, left LC=356; central=290; peripheral=478. Variables selected for 10YS study were input levels of 45 blood parameters, sex, age, TNMG, cell type, tumor size. Survival curves were estimated by the Kaplan-Meier method. Differences in curves between groups of LCP were evaluated using a log-rank test. Multivariate Cox modeling, analysis, clustering, SEPATH, Monte Carlo, bootstrap and neural networks computing were used to determine any significant dependence. Results: Overall life span (LS) was 2244.9±1750.3 days and cumulative 5-year survival (5YS) reached 72.9%, 10 years – 64.3%, 20 years – 43.1%. 502 LCP lived more than 5 years (LS=3128.7±1536.8 days), 145 LCP – more than 10 years (LS=5068.5±1513.2 days).199 LCP died because of LC (LS=562.7±374.5 days). AT significantly improved 10YS (52.4% vs. 27.7%) (P=0.00002 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 10YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time, weight, color index (P=0.000-0.039). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 10YS and PT early-invasive LC (rank=1), thrombocytes/CC (rank=2), PT N0—N12(rank=3), segmented neutrophils/CC (4), healthy cells/CC (5), lymphocytes/CC (6), erythrocytes/CC (7), stick neutrophils/CC (8), eosinophils/CC (9), leucocytes/CC (10), monocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0). Conclusions: 10-Year survival of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) anthropometric data; 10) surgery type. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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B. K. Yadav, Indra Mani e J. S. Panwar. "Relationship Between Disc Geometry and Draft Requirement". Journal of Agricultural Engineering (India) 43, n. 1 (31 marzo 2006): 49–52. http://dx.doi.org/10.52151/jae2006431.1158.
Abstract (sommario):
A disc is considered as part of shell of a hallow sphere and used as soil working tool with tillage implement. Detailed information about the effect of disc geometry specially disc diameter with varying concavity is not available. A single disc tool carrier was designed to mount and test the performance of disc of different diameter and concavity. A total of nine discs in the diameter range of 510-610 mm and concavity within 51-95 mm were tested under field conditions for their draft requirement and work performance. The results showed that draft increased consistently with increase in diameter of the disc but the range of variation was low. The draft range in unploughed soil for 510, 560 and 610 mm disc was observed as 177-194,192-204 and 176-227 kg respectively. The increase in draft for higher diameter disc was mainly due to increase in width of cut. Disc concavity showed a pronounced effect on draft. Over the three levels of diameter, the concavity variation of 17,14 and19mm caused draft variations of 14,18 and 43 kg, respectively, in the same order.
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Rodrigues, Alisson Mendes, Fabiana Pereira da Costa, Suellen Lisboa Dias Beltrão, Jucielle Veras Fernandes, Romualdo Rodrigues Menezes e Gelmires de Araújo Neves. "Development of Eco-Friendly Mortars Produced with Kaolin Processing Waste: Durability Behavior Viewpoint". Sustainability 13, n. 20 (15 ottobre 2021): 11395. http://dx.doi.org/10.3390/su132011395.
Abstract (sommario):
This study presents the development of new eco-friendly mortar compositions containing kaolin residues (KR) and assesses their durability behavior. Firstly, the natural and calcinated kaolin residues (600 °C, 650 °C, 700 °C, 750 °C, and 800 °C) were characterized by X-ray diffraction (XRD), differential thermal analysis (DTA), granulometric analysis, and surface area. The kaolin residue calcinated at 800 °C was chosen to be added to new compositions of mortar because it presented the best pozzolanic performance. The aging tests accomplished in internal (Ei) and external (Ee) environments were applied in mortars with a mass proportion of 1:2:6 (cement + KR: lime: sand), in which the KR, calcinated at 800 °C, replaced the cement in the mass fraction of 0%, 5%, 10%, 15%, 20%, and 30%. The Ei was performed for 30, 60, 90, 180, and 360 days, and the Ee for 90; 210; 360; and 512 days. After the aging tests were completed, the mortar compositions containing KR were evaluated to determine their mineralogical phases (XRD), compressive strength (CS), and thermal behavior (DTA and thermogravimetry). In summary, the KR addition to the mortar compositions decreases the mechanical resistance to compression; however, mortars with a substitution of 10% and 20% presented resistance values within the minimum limit of 2.4 MPa established by ASTM C 270.
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Tepper, Stewart J., Hans-Christoph Diener, Messoud Ashina, Jan Lewis Brandes, Deborah I. Friedman, Uwe Reuter, Sunfa Cheng et al. "Erenumab in chronic migraine with medication overuse". Neurology 92, n. 20 (17 aprile 2019): e2309-e2320. http://dx.doi.org/10.1212/wnl.0000000000007497.
Abstract (sommario):
ObjectiveTo determine the effect of erenumab, a human anti-calcitonin gene-related peptide receptor monoclonal antibody, in patients with chronic migraine and medication overuse.MethodsIn this double-blind, placebo-controlled study, 667 adults with chronic migraine were randomized (3:2:2) to placebo or erenumab (70 or 140 mg), stratified by region and medication overuse status. Data from patients with baseline medication overuse at baseline were used to assess changes in monthly migraine days, acute migraine-specific medication treatment days, and proportion of patients achieving ≥50% reduction from baseline in monthly migraine days.ResultsOf 667 patients randomized, 41% (n = 274) met medication overuse criteria. In the medication overuse subgroup, erenumab 70 or 140 mg groups had greater reductions than the placebo group at month 3 in monthly migraine days (mean [95% confidence interval] −6.6 [−8.0 to −5.3] and −6.6 [−8.0 to −5.3] vs −3.5 [−4.6 to −2.4]) and acute migraine-specific medication treatment days (−5.4 [−6.5 to −4.4] and −4.9 [−6.0 to −3.8] vs −2.1 [−3.0 to −1.2]). In the placebo and 70 and 140 mg groups, ≥50% reductions in monthly migraine days were achieved by 18%, 36% (odds ratio [95% confidence interval] 2.67 [1.36–5.22]) and 35% (odds ratio 2.51 [1.28–4.94]). These clinical responses paralleled improvements in patient-reported outcomes with a consistent benefit of erenumab across multiple measures of impact, disability, and health-related quality of life. The observed treatment effects were similar in the non–medication overuse subgroup.ConclusionsErenumab reduced migraine frequency and acute migraine-specific medication treatment days in patients with chronic migraine and medication overuse, improving disability and quality of life.Clinicaltrials.gov identifierNCT02066415.Classification of evidenceThis study provides Class II evidence that erenumab reduces monthly migraine days at 3 months in patients with chronic migraine and medication overuse.
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Wimalasingham, Akhila Ganeshi, Alfonso Gomez De Liano Lista, Roderick de Bruijn, John B. A. G. Haanen, Bernadett Szabados, Peter Hall, Christian U. Blank et al. "Meta-analysis of upfront VEGF targeted therapy prior to nephrectomy in metastatic clear cell renal cancer." Journal of Clinical Oncology 35, n. 6_suppl (20 febbraio 2017): 514. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.514.
Abstract (sommario):
514 Background: The safety and efficacy of upfront VEGF targeted, before nephrectomy in metastatic clear cell renal cancer (mCCRC) has not been robustly evaluated. Methods: In this study we performed a meta-analysis of 3 studies (NCT) with an almost identical design and included a single institution experience (which adopted this approach as a standard). Patients with newly diagnosed mCCRC had 12-18 weeks of sunitinib or pazopanib therapy prior to planned cytoreductive nephrectomy (CN). Results: 224 patients were included in this analysis (54% had sunitinib and 46% pazopanib). Overall, 73% had MSKCC intermediate risk and 23% poor risk disease. 20% of patients had an ECOG performance status of 0.84% of patients obtained stable disease or a response to therapy (by RECIST) before surgery. The median reduction of size of the primary tumour was 14%. 60% of patients had CN. The commonest reason for not performing CN was progression of disease. Progression free survival (PFS) and overall survival (OS) was 6.2 (95% CI 5.7-6.7) and 13 (95% CI: 10.2-15.7) respectively. Patients with MSKCC poor risk disease had a poor outcome irrespective of CN (OS = 7.5 months 95% CI 5.8-9.2). A comparison of sunitinib and pazopanib showed no significant difference in median PFS 7.1 (95% CI, 6.0-9.2) and 6.0 (95% CI: 5.1-6.8) or surgical complications (p<0.05). Conclusions: Outcomes with this approach are in line with expected survival for this population. Results with sunitinib and pazopanib were similar. This approach is attractive for patients with MSKCC intermediate risk disease.
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Kamdin, Farzan, Kruti Khemani e Annamma Varghese. "COVID-19 lockdown impact on physical activity and anxiety levels among physiotherapy practitioners, teaching faculty and students in Mumbai: a cross-sectional web-based e-survey study". International Journal Of Community Medicine And Public Health 8, n. 5 (27 aprile 2021): 2406. http://dx.doi.org/10.18203/2394-6040.ijcmph20211765.
Abstract (sommario):
Background: Coronavirus (COVID-19) has spread rapidly throughout the world leading to an emergency global pandemic. Among the varied affected sections of the population and healthcare, physiotherapy is no exception. To what extent, both the physical activity and anxiety levels have been affected amongst the physiotherapy practitioners, teaching faculty and students is not completely known. Hence, this study was undertaken.Methods: Among a potential 400 participants, 357 responded (response rate=89.25%). Cross-sectional web based open e-survey was sent using google forms via emails and social media platforms such as Whatsapp, facebook, instagram and linkedin messenger. The primary outcome measures were international physical activity questionnaire-short form (IPAQ-SF) for self-reported physical activity and general anxiety disorder (GAD-7) questionnaire for measuring self-reported anxiety.Results: Out of the 357 participants, 40 were inactive (<600 METs/week), 175 were minimally active (600-3000 METs/week) and 142 were health enhancing physically active (>3000 METs/week). The GAD-7 score showed a significant proportion of participants (74%) to have mild to moderate anxiety and only 26% had moderately severe to severe anxiety. Physiotherapy students were found to do least amount of physical activity in a week (mean METs/week of 2590) and were also more anxious with an average GAD-7 score of 7.7. Practicing physiotherapists and teachers had better scores of 3285 and 3028 METs/week and also better mean GAD-7 scores at 6.4 and 5.3, respectively.Conclusions: The lockdown caused by the COVID-19 pandemic has affected the physical activity levels and mental wellbeing of physiotherapy students more than the physiotherapy practitioners and teaching faculty.
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Matsuyama, Hideyasu, Nobuaki Matsubara, Tomoyuki Taguchi, Takeshi Seto e Kazuhiro Suzuki. "Post marketing surveillance study of cabazitaxel (CBZ) in Japanese patients with castration resistant prostate cancer (CRPC) in real world settings." Journal of Clinical Oncology 36, n. 6_suppl (20 febbraio 2018): 290. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.290.
Abstract (sommario):
290 Background: The study evaluated safety and efficacy of CBZ in Japanese patients (pts) with CRPC in real world settings. Methods: This prospective, observational study targeted all CRPC pts receiving CBZ in daily practice between September 2014 and June 2015. Observation period was 1 year after first dose of CBZ given. Adverse drug reactions (ADRs) were evaluated for safety by CTCAE 4.0. Overall survival (OS), time to treatment failure (TTF) and prostate specific antigen (PSA) response rate (≥30% PSA decrease) were the efficacy endpoints. Two groups, those given 25mg/m2 of CBZ as initial dose (C25) and those given 20mg/m2 of CBZ (C20), were comparatively analyzed. This study was supported by Sanofi. Results: Of 662 enrolled pts with CRPC treated with CBZ, 660 pts were analyzed. ADRs occurred in 511 pts (77.4%). Most frequent all grade ADRs were neutropenia (49.2%), febrile neutropenia (18.0%) and anemia (14.2%). Median OS and TTF were 319 and 116 days, respectively. Of 540 PSA evaluable pts, 158 (29.3%) achieved PSA response. Populations for post hoc analysis were 159 pts for C25 and 190 pts for C20. Patient characteristics were similar C25 and C20 groups. Statistical significant differences were observed between C25 and C20 groups for OS (Hazzard Ratio [HR] = 0.71) and TTF (HR = 0.78) in favor of C25 group. Initial dose of CBZ remained as the independent prognostic factor for OS and TTF in univariate and multivariate analysis. There was no significant difference for PSA response rate. ≥ Grade 3 ADRs with C25 and C20 occurred in 129 pts (81.1%) and 116 pts (61.1%), respectively. Conclusions: Safety profile of CBZ was generally consistent with clinical studies conducted before approval in Japan. Although there are some limitations of studies done in real world settings, there were significant differences for OS and TTF between C25 and C20. Less ADRs occurred with C20. [Table: see text]
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Han, Molong, Ashok Meghwal, Soon Hock Ng, Daniel Smith, Haoran Mu, Tomas Katkus, De Ming Zhu et al. "Microparticles of High Entropy Alloys Made by Laser-Induced Forward Transfer". Materials 15, n. 22 (15 novembre 2022): 8063. http://dx.doi.org/10.3390/ma15228063.
Abstract (sommario):
The controlled deposition of CoCrFeNiMo0.2 high-entropy alloy (HEA) microparticles was achieved by using laser-induced forward transfer (LIFT). Ultra-short laser pulses of 230 fs of 515 nm wavelength were tightly focused into ∼2.4 μm focal spots on the ∼50-nm thick plasma-sputtered films of CoCrFeNiMo0.2. The morphology of HEA microparticles can be controlled at different fluences. The HEA films were transferred onto glass substrates by magnetron sputtering in a vacuum (10−8 atm) from the thermal spray-coated substrates. The absorption coefficient of CoCrFeNiMo0.2α≈6×105 cm−1 was determined at 600-nm wavelength. The real and imaginary parts of the refractive index (n+iκ) of HEA were determined from reflectance and transmittance by using nanofilms.
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Pulito-Cueto, V., F. Genre Romero, S. Remuzgo Martinez, B. Sevilla, N. Ortego, M. Leonardo, A. Peñalba et al. "AB0166 IGAV AND IGAN: A SINGLE ENTITY REGARDING CD40, BLK AND BANK1 POLYMORPHISMS". Annals of the Rheumatic Diseases 82, Suppl 1 (30 maggio 2023): 1263.2–1264. http://dx.doi.org/10.1136/annrheumdis-2023-eular.81.
Abstract (sommario):
BackgroundIgA vasculitis (IgAV) and IgA nephropathy (IgAN) are inflammatory conditions that share pathophysiological mechanisms, being B-cells crucial players in both diseases [1]. In this regard, some authors have suggested that IgAV and IgAN may represent different outcomes of a continuous spectrum of a disease [2]. In addition,CD40, BLKandBANK1are relevant genes involved in the development and signalling of B-cells and are also identified as susceptibilitylocifor several immune-mediated diseases [3-6].ObjectivesTo determine whether IgAV and IgAN may be different outcomes of a single disease, by assessing theCD40, BLKandBANK1genetic pattern.MethodsThree genetic variants withinCD40(rs1883832, rs1535045, rs4813003), three genetic polymorphisms withinBLK(rs2254546, rs2736340, rs2618476) as well as twoBANK1genetic variants (rs10516487, rs3733197) were genotyped in 380 Caucasian patients diagnosed with IgAV, 90 patients diagnosed with IgAN and 1,012 ethnically matched healthy controls. The eight polymorphisms selected were previously associated with several inflammatory diseases [3-6].ResultsSimilar genotype and allele frequencies were observed in IgAV patients when compared to those with IgAN, whenCD40, BLKandBANK1variants were analyzed independently (Table 1). In addition, no statistically significant differences were observed between patients with IgAV and healthy controls as well as between patients with IgAN and healthy controls, whenCD40, BLKandBANK1genetic variants were analyzed independently (Table 1). Similar results were disclosed when haplotype frequencies ofCD40, BLKandBANK1were compared between patients with IgAV and those with IgAN, as well as between patients with IgAV and healthy controls and between IgAN and healthy controls.ConclusionOur results reveal a similarCD40, BLKandBANK1genetic distribution in IgAV and IgAN, supporting that IgAV and IgAN may represent different outcomes of a single disease.References[1] N Engl J Med 2013;368:2402-14;[2] Am J Kidney Dis 1988;12:373-7;[3] Nat Genet 2009;41:824-8;[4] Ann Rheum Dis 2012;71:136-42;[5] Nat Genet 2012;44:517-21;[6] Nat Genet 2012;44:522-5.Table 1.Genotype and allele frequencies ofCD40, BLKandBANK1in patients with IgAV, patients with IgAN and healthy controls.ChangeGenotypes, % (n)Alleles, % (n)Polymorphism1/2Data set1/11/22/212CD40rs1883832C/TIgAV54.0 (204)37.0 (140)9.0 (34)72.5 (548)27.5 (208)IgAN56.5 (48)36.5 (31)7.0 (6)74.7 (127)25.3 (43)Healthy controls52.9 (532)40.4 (409)6.7 (68)73.1 (1,479)26.9 (545)CD40rs1535045C/TIgAV53.6 (200)39.4 (147)7.0 (26)73.3 (547)26.7 (199)IgAN51.8 (44)41.2 (35)7.1 (6)72.4 (123)27.6 (47)Healthy controls56.7 (574)36.2 (366)7.1 (72)74.8 (1,514)25.2 (510)CD40rs4813003C/TIgAV78.0 (291)20.1 (75)1.9 (7)88.1 (657)11.9 (89)IgAN76.6 (59)20.8 (16)2.6 (2)87.0 (134)13.0 (20)Healthy controls74.9 (758)22.7 (230)2.4 (24)86.3 (1,746)13.7 (278)BLKrs2254546G/AIgAV74.5 (278)22.3 (83)3.2 (12)85.7 (639)14.3 (107)IgAN64.7 (55)31.8 (27)3.5 (3)80.6 (137)19.4 (33)Healthy controls71.3 (722)26.8 (271)1.9 (19)84.7 (1,715)15.3 (309)BLKrs2736340C/TIgAV62.8 (236)31.9 (120)5.3 (20)78.7 (592)21.3 (160)IgAN67.5 (52)31.2 (24)1.3 (1)83.1 (128)16.9 (26)Healthy controls59.9 (606)35.8 (362)4.3 (44)77.8 (1,574)22.2 (450)BLKrs2618476T/CIgAV60.2 (227)34.2 (129)5.6 (21)77.3 (583)22.7 (171)IgAN68.2 (58)24.7 (21)7.1 (6)80.6 (137)19.4 (33)Healthy controls57.9 (586)37.3 (377)4.8 (49)76.5 (1,549)23.5 (475)BANK1rs10516487G/AIgAV52.8 (200)39.8 (151)7.4 (28)72.7 (551)27.3 (207)IgAN50.6 (42)38.6 (32)10.8 (9)69.9 (116)30.1 (50)Healthy controls50.8 (514)41.8 (423)7.4 (75)71.7 (1,451)28.3 (573)BANK1rs3733197G/AIgAV50.0 (187)39.0 (146)11.0 (41)69.5 (520)30.5 (228)IgAN47.1 (40)37.6 (32)15.3 (13)65.9 (112)34.1 (58)Healthy controls49.5 (501)41.6 (421)8.9 (90)70.3 (1,423)29.7 (601)AcknowledgementsThis study has been funded by Instituto de Salud Carlos III (ISCIII) through the project PI18/00042 and PI21/00042, co-funded by European Regional Development Fund (ERDF), `Investing in your future´; VP-C: PI18/00042 from ISCIII, co-funded by ERDF; MSM-G is supported by funds of TRANSVAL22/01 from IDIVAL; RL-M: Miguel Servet type II programme fellowship from the ISCIII, co-funded by the European Social Fund (`Investing in your future´) [CPII21/00004].Disclosure of InterestsVerónica Pulito-Cueto: None declared, Fernanda Genre Romero: None declared, Sara Remuzgo Martinez: None declared, Belén Sevilla: None declared, Norberto Ortego: None declared, Maite Leonardo: None declared, Ana Peñalba: None declared, J. Narváez: None declared, Luis Martín-Penagos: None declared, Lara Belmar-Vega: None declared, Cristina Gomez-Fernandez: None declared, María Sebastián Mora-Gil: None declared, LUIS CAMINAL MONTERO: None declared, PAZ COLLADO: None declared, Antonio Fernandez-Nebro: None declared, Gisela Diaz-Cordobes: None declared, Secundino Cigarrán: None declared, Jesús Calviño: None declared, Carmen Cobelo: None declared, Diego de Argila: None declared, Javier Sanchez Perez: None declared, Miren Uriarte-Ecenarro: None declared, Esteban Rubio-Romero: None declared, MANUEL LEON LUQUE: None declared, Juan María Blanco-Madrigal: None declared, E. Galíndez-Agirregoikoa: None declared, Javier Martin Ibanez: None declared, Santos Castañeda: None declared, Miguel A González-Gay Speakers bureau: Abbvie, Pfizer, Roche, Sanofi, Lilly, Celgene, MSD and GSK, Grant/research support from: Abbvie, MSD, Jansen and Roche, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Raquel López-Mejías: None declared.
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Salah alhalbusi, Ghazwan, e A’amal A. H. Al-Saidi. "Enhancing the Ability of The Square Footing to Resist Positive and Negative Eccentric Inclined Loading Using an Inclined Skirt". E3S Web of Conferences 427 (2023): 01020. http://dx.doi.org/10.1051/e3sconf/202342701020.
Abstract (sommario):
Laboratory model tests were performed to investigate the behavior of shallow and inclined skirted foundations placed on sandy soil with R.D%=30 and the extent of the impact of the positive and negative eccentric-inclined loading effect on them. To achieve the experimental tests, it was used a box of (600×600) mm cross-sectional and 600mm in height and a square footing of (50*50) mm and 10 mm in thickness attached to the skirt with Ds=0.5B and various an angle of (10°, 20°, 30°). The results showed that using skirts leads to a significant improvement in load-carrying capacity and decreased settlement. In addition, when the skirt angle increased, the ultimate load improved. Load-carrying capacity decreased with increasing eccentricity and load inclination. For load inclination (Beta) 15° when the eccentricity changed from e=0.15B to e=0.05B, the load improvement percentages were (323.2 to 263%) and (214 to 220%). The settlement reduction factor was (83 to 78%) and (62 to 58%) for positive and negative eccentric-inclined loading, respectively. Also, the result showed that the positive effect on reducing soil-bearing capacity is more than the negative. Increasing eccentricity increases the improvement percentage for positive eccentric-inclined load and decreases for the case of negative eccentric-inclined load. Increased skirt angle will increase the Improvement factor (IR). When the skirt angle increased from 10° to 30° for an improved foundation with load angles of 5°, 10°, and 15°, the improvement factor (IR) increased from (2.53, 2.51, 2.4) to (3.45, 3.65, 3.97) and (2.43, 2.58, 2.54) to (4, 4.63, 5.3) for both negative and positive eccentric-inclined load respectively and settlement reduction factor for load angle 15° and skirt angle increase from 10° to 30° were 34% and 27% for positive and negative eccentric-inclined load respectively. The (IR) for the positive eccentric-inclined load is more than the negative eccentric-inclined load for all cases. In addition, the skirt angle of 30° significantly improved the improvement factor (IR).
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Watanabe, Yasumasa, Alec Houpt e Sergey Leonov. "Plasma-Assisted Control of Supersonic Flow over a Compression Ramp". Aerospace 6, n. 3 (12 marzo 2019): 35. http://dx.doi.org/10.3390/aerospace6030035.
Abstract (sommario):
This study considers the effect of an electric discharge on the flow structure near a 19.4° compression ramp in Mach-2 supersonic flow. The experiments were conducted in the supersonic wind tunnel SBR-50 at the University of Notre Dame. The stagnation temperature and pressure were varied in a range of 294–600 K and 1–3 bar, respectively, to attain various Reynolds numbers ranging from 5.3 × 105 to 3.4 × 106 based on the distance between the exit of the Mach-2 nozzle and the leading edge of the ramp. Surface pressure measurements, schlieren visualization, discharge voltage and current measurements, and plasma imaging with a high-speed camera were used to evaluate the plasma control authority on the ramp pressure distribution. The plasma being generated in front of the compression ramp shifted the shock position from the ramp corner to the electrode location, forming a flow separation zone ahead of the ramp. It was found that the pressure on the compression surface reduced almost linearly with the plasma power. The ratio of pressure change to flow stagnation pressure was also an increasing function of the ratio of plasma power to enthalpy flux, indicating that the task-related plasma control effectiveness ranged from 17.5 to 25.
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Wibisono Nugraha, Eka Devinta Novi Diana, Frieda, Alfina Rahma e Prasetyadi Mawardi. "Secondary Syphilis in the Second Trimester Pregnancy : Case Report". Indian Journal of Forensic Medicine & Toxicology 16, n. 1 (30 novembre 2021): 1263–70. http://dx.doi.org/10.37506/ijfmt.v16i1.17670.
Abstract (sommario):
Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum, which is transmitted through sexual contact, blood transfusion and transplacental from an infected mother to the fetus. Syphilis in pregnancy can cause complications including abortion, low birth weight, premature birth, neonatal death or congenital syphilis infection.Case: A 39-year-old woman, 16 weeks pregnant, presented with a complaint of a small lump on the genitals accompanied by red patches on the palms of the hands and feet. Serological tests showed a reactive VDRL of 1:512 and a reactive TPHA of 1:640. Based on the history, physical examination and serological tests the patient was diagnosed with secondary syphilis in pregnancy. The management of this patient was given a single dose of Benzathine Penicillin G injection of 2.4 million units intramuscularly.Conclusion: Early screening for syphilis in pregnancy isvery important to prevent complications in the fetus. VDRL serological test examination 3 months after therapy was carried out to determine the success of therapy. In this case, there was a decrease in the VDRL titer to 1:4 in the absence of skin lesions 3 months after therapy with benzathine penicillin G 2.4 million units intramuscularly single dose.
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He, S. Y., Y. Q. Yu, G. C. Zhang e Q. R. Yang. "Effects of Vacuum Pre-Cooling on Quality of Mushroom after Cooling and Storage". Advanced Materials Research 699 (maggio 2013): 189–93. http://dx.doi.org/10.4028/www.scientific.net/amr.699.189.
Abstract (sommario):
Experiments were conducted to determine if vacuum cooling has an effect on the physical and chemical quality characteristics of mushroom after cooling and storage. Pressure, temperature and mass variations of mushroom were obtained during vacuum cooling. The pressure was decreased from 10000 Pa to 600 Pa within 4 min and then maintained it until the end of vacuum cooling process. Accordingly the temperature of mushroom dropped from initial 25.1 °C to 2.4 °C within 25 min, and the mass loss was 5.3%. Subsequently, vacuum cooled mushroom were stored at 1±0.5°C. and 85-95% of relative humidity for 2 weeks. The effects of vacuum cooling on the color, firmness, polyphenol oxidase and membrane permeability of mushroom after cooling and storage were determined. The results showed that vacuum cooling significantly reduced the polyphenol oxidase and membrane permeability.
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Goodman, Rachel S., J. Randall Patrinely, Cosby A. Stone, Eli Zimmerman, Rebecca R. Donald, Sam S. Chang, Sean T. Berkowitz et al. "Accuracy and Reliability of Chatbot Responses to Physician Questions". JAMA Network Open 6, n. 10 (2 ottobre 2023): e2336483. http://dx.doi.org/10.1001/jamanetworkopen.2023.36483.
Abstract (sommario):
ImportanceNatural language processing tools, such as ChatGPT (generative pretrained transformer, hereafter referred to as chatbot), have the potential to radically enhance the accessibility of medical information for health professionals and patients. Assessing the safety and efficacy of these tools in answering physician-generated questions is critical to determining their suitability in clinical settings, facilitating complex decision-making, and optimizing health care efficiency.ObjectiveTo assess the accuracy and comprehensiveness of chatbot-generated responses to physician-developed medical queries, highlighting the reliability and limitations of artificial intelligence–generated medical information.Design, Setting, and ParticipantsThirty-three physicians across 17 specialties generated 284 medical questions that they subjectively classified as easy, medium, or hard with either binary (yes or no) or descriptive answers. The physicians then graded the chatbot-generated answers to these questions for accuracy (6-point Likert scale with 1 being completely incorrect and 6 being completely correct) and completeness (3-point Likert scale, with 1 being incomplete and 3 being complete plus additional context). Scores were summarized with descriptive statistics and compared using the Mann-Whitney U test or the Kruskal-Wallis test. The study (including data analysis) was conducted from January to May 2023.Main Outcomes and MeasuresAccuracy, completeness, and consistency over time and between 2 different versions (GPT-3.5 and GPT-4) of chatbot-generated medical responses.ResultsAcross all questions (n = 284) generated by 33 physicians (31 faculty members and 2 recent graduates from residency or fellowship programs) across 17 specialties, the median accuracy score was 5.5 (IQR, 4.0-6.0) (between almost completely and complete correct) with a mean (SD) score of 4.8 (1.6) (between mostly and almost completely correct). The median completeness score was 3.0 (IQR, 2.0-3.0) (complete and comprehensive) with a mean (SD) score of 2.5 (0.7). For questions rated easy, medium, and hard, the median accuracy scores were 6.0 (IQR, 5.0-6.0), 5.5 (IQR, 5.0-6.0), and 5.0 (IQR, 4.0-6.0), respectively (mean [SD] scores were 5.0 [1.5], 4.7 [1.7], and 4.6 [1.6], respectively; P = .05). Accuracy scores for binary and descriptive questions were similar (median score, 6.0 [IQR, 4.0-6.0] vs 5.0 [IQR, 3.4-6.0]; mean [SD] score, 4.9 [1.6] vs 4.7 [1.6]; P = .07). Of 36 questions with scores of 1.0 to 2.0, 34 were requeried or regraded 8 to 17 days later with substantial improvement (median score 2.0 [IQR, 1.0-3.0] vs 4.0 [IQR, 2.0-5.3]; P &lt; .01). A subset of questions, regardless of initial scores (version 3.5), were regenerated and rescored using version 4 with improvement (mean accuracy [SD] score, 5.2 [1.5] vs 5.7 [0.8]; median score, 6.0 [IQR, 5.0-6.0] for original and 6.0 [IQR, 6.0-6.0] for rescored; P = .002).Conclusions and RelevanceIn this cross-sectional study, chatbot generated largely accurate information to diverse medical queries as judged by academic physician specialists with improvement over time, although it had important limitations. Further research and model development are needed to correct inaccuracies and for validation.
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Trifilio, S., M. K. Khalid, G. Pennick, J. Pi, N. Bainbridge, J. Zook e J. Mehta. "Voriconazole Therapeutic Drug Monitoring: Relationship between Drug Levels and Liver Function Tests." Blood 108, n. 11 (16 novembre 2006): 2950. http://dx.doi.org/10.1182/blood.v108.11.2950.2950.
Abstract (sommario):
Abstract Voriconazole is increasingly being used after HSCT. The hepatic cytochrome P450 isoenzyme 2C19 plays a significant role in voriconazole metabolism. As CYP2C19 exhibits significant genetic polymorphism, some patients metabolize voriconazole poorly resulting in increased plasma drug levels. However, the clinical significance of this is unknown. There is some evidence that toxicity rates are higher in patients with higher voriconazole levels (Boyd et al. Clin Infect Dis2004;39:1241–1244). In a preliminary study of 41 voriconazole levels in 25 patients, we had found that voriconazole levels correlated with aspartate aminotransferase (AST) and alkaline phosphatase (AP) levels (Trifilio et al. Bone Marrow Transplant2005;35:509–513). It was unclear if the abnormal liver function was the cause or the result of higher voriconazole levels. To further elucidate this relationship, we analyzed data on 171 steady-state plasma trough levels performed after at least 5 days of voriconazole therapy in 87 patients with hematologic malignancies. There were 1–5 levels per patient (median 2). Most patients had undergone allogeneic hematopoietic stem cell transplantation. Drug levels were monitored using HPLC (Pennick et al. Antimicrob Agents Chemother2003;47:2348–2350). Of the 201 samples assayed, 30 were below the detection limit of the assay (0.2 μg/mL), and were excluded. The daily voriconazole dose (divided into 2) was 200 mg (n=3), 400 mg (n=129), 500 mg (n=18), 600 mg (n=15), or 800 mg (n=6); corresponding to 2.0–13.3 mg/kg (median 5.3). The voriconazole levels were 0.2–12.5 μg/mL (median 1.7). The table shows the correlation between voriconazole levels, and weight, dose and biochemical parameters individually. However, in multivariate regression analysis, the parameters found to correlate significantly with voriconazole levels were ALT (P=0.0005), AST (P=0.003), and AP (P=0.027). The relationship with albumin was of borderline significance (P=0.062). Importantly, the daily dose of voriconazole in mg or in mg/kg was not predictive of drug levels. This larger data set confirms our previous observation that there is a significant relationship between elevated liver function tests and higher voriconazole levels. However, because of the relatively high frequency of abnormal liver function tests in such groups of patients, the cause-effect relationship still remains uncertain. These data suggest that pending further clarification, voriconazole levels may need to be monitored in patients with significantly abnormal liver function tests. Parameter Median (range) r P Dose (mg) 400 (200–800) 0.19 0.013 Weight (kg) 80 (39–135) 0.18 0.018 Dose (mg/kg) 5.3 (2.0–13.3) 0.23 0.002 ALT (IU/L) 25 (4–608) 0.10 0.25 AST (IU/L) 25 (6–524) 0.14 0.11 AP (IU/L) 95 (27–920) 0.27 0.002 Bilirubin (mg/dL) 1.1 (0.1–17.3) 0.01 0.89 Albumin (g/dL) 2.4 (0.8–3.9) 0.28 0.001 Creatinine (mg/dL) 1.1 (0.2–10.1) 0.01 0.92
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Nicolaeva, B. K., e A. P. Borisov. "Development of a Software and Hardware Complex for Investigation of the Velocity Vector Field in a Cyclone Separator". Bulletin of Kalashnikov ISTU 21, n. 2 (2 luglio 2018): 204. http://dx.doi.org/10.22213/2413-1172-2018-2-204-210.
Abstract (sommario):
Рассмотрен актуальный вопрос автоматизации и исследования векторного поля скоростей в циклоне-сепараторе с винтовой вставкой. В отличие от циклонов, используемых сейчас на зерноперерабатывающих предприятиях, имеющих эффективность 80 %, циклон-сепаратор с винтовой вставкой позволяет увеличить эффективность очистки до 99,5-99,9 %, что позволяет более эффективно использовать его во взрывоопасном мукомольном производстве. Для выявления эффективных режимов работы и параметров циклона-сепаратора было проведено моделирование векторного поля скоростей в SolidWorks, исследованы тангенциальная, осевая и радиальная скорости. Также был разработан программно-аппаратный комплекс, позволяющий получать данные о скорости внутри циклона-сепаратора. Основой разработанного программно-аппаратного комплекса является Raspberry Pi, позволяющий с высокой скоростью обрабатывать полученные данные. Также в статье описаны принципы работы разработанного комплекса. Результаты эксперимента показали, что на мучной пыли эффективность рассматриваемого циклона-сепаратора превысила 99,5 %, при этом расход воздуха составил 376 м3/ч, 472 м3/ч и 516 м3/ч, а ΔР - менее 600 Па. Скорость во входном патрубке винтовой вставки составила 18-20 м/с, а на выходе из винтовой вставки скорость воздушного потока составляет 50-70 м/с.
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Sukauichai, Sitthi, Kulthida Maneenil, Archara Supavavej, Vinai Paul, Duangnapa Benjawongsathien, Chaichana Chantharakhit, Sunee Neesanun, Chawalit Chayangsu, Thissawan Bowornkitiwong e Napawan Sukaraphat. "EGFR Mutation-positive Lung Cancer in Real-world Treatment Outcomes: A Multicenter Study from Thailand". Asian Pacific Journal of Cancer Care 7, n. 4 (10 novembre 2022): 643–50. http://dx.doi.org/10.31557/apjcc.2022.7.4.643-650.
Abstract (sommario):
Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been the standard of care as first-line (1L) therapy for patients with advanced EGFR mutated lung cancer since 2009. In Thailand, however, it was not fully introduced to all health care funds until 2020. The purpose of this study was to determine the overall survival (OS) and treatment pattern in the period before EGFR-TKI became universally available to all patients.
Methods: This was a retrospective study conducted at 10 medical centers in Thailand. Patients harboring the common mutation (exon 19 deletion or exon 21 L858R) diagnosed during January 2013 and December 2019 were enrolled.
Results: This study included 284 patients with a median follow-up time of 19.8 months and a death rate of 80.3% (228/284). Clinical characteristics included median age 62.5 years, female 65.5%, never-smoking 74.3%, stage 3B/4/recurrence 2.1/93.3/4.6%, exon 19/exon 21- 60.9/38.7%. Treatment patterns to EGFR-TKI included not receiving (NR) (9.5%), first-line (1L) (56.0%), switch maintenance (MN) (3.5%), second-line (2L) (21.8%) and third-line (3L) or more (9.2%). Median OS of patient receiving EGFR-TKI as NR, 1L+MN, 2L and 3L or more was 11.10 (95%CI: 8.21 to14.00), 19.08 (95%CI: 15.76 to 22.41), 23.06 (95%CI: 15.91 to 30.21) and 32.46 (95%CI: 21.61 to 43.30) months (p=0.006), respectively. Factors contributing to poor prognosis in the multivariate model included poor ECOG-PS (HR 3.17, 95%CI: 1.96-5.13), not receiving EGFR-TKI (HR 3.83, 95%CI, 1.94-7.56) and receiving EGFR-TKI 1L (HR 2.30, 95%CI: 1.40-3.79)
Conclusion: OS of patients with EGFR mutation positive lung cancer treated with EGFR-TKIs in Thailand was comparable to clinical studies. EGFR-TKI treatment should be provided to patients as early as possible, but TKI remained beneficial at later points in the treatment timeline.
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Truett, A. P., R. Snyderman e J. J. Murray. "Stimulation of phosphorylcholine turnover and diacylglycerol production in human polymorphonuclear leukocytes. Novel assay for phosphorylcholine". Biochemical Journal 260, n. 3 (15 giugno 1989): 909–13. http://dx.doi.org/10.1042/bj2600909.
Abstract (sommario):
Receptor-bypassing stimulants of human polymorphonuclear leukocytes (PMNLs), such as ionomycin or phorbol 12-myristate 13-acetate (PMA), generate an increase in diacylglycerol (DAG) which is independent of a phospholipase C specific for phosphatidylinositol 4,5,-bisphosphate (PIP2). Activation of a phospholipase C specific for phosphatidylcholine (PC) has been implicated as a source of DAG in other cells by measuring the release of radiolabelled phosphorylcholine. However, since PMNLs could not be labelled sufficiently with [3H]choline, we developed an h.p.l.c. assay to quantify mass levels of phosphorylcholine after enzymic conversion to [32P]CDP-choline with CTP-phosphorylcholine (choline phosphate) cytidylyltransferase (EC 2.7.7.15). This assay was linear to at least 20 nmol, and was sensitive to 10 pmol of phosphorylcholine. Baseline phosphorylcholine levels in unstimulated PMNLs were 2300 +/- 510 pmol/10(7) cells and were decreased by pretreatment with PMA (166 nM) or ionomycin (1 microM) for 10 min by 360 +/- 130 and 600 +/- 290 pmol/10(7) cells respectively (P less than 0.05). In contrast, baseline DAG levels were 147.6 +/- 11.7 pmol/10(7) cells in unstimulated PMNLs, and were increased by PMA or ionomycin by 1320 +/- 222 and 1891 +/- 264 pmol/10(7) cells respectively (P less than 0.05). Similarly, the chemoattractant fMet-Leu-Phe raised DAG levels by 731 +/- 111 pmol/10(7) cells and decreased phosphorylcholine levels by 180 +/- 60 pmol/10(7) cells. Activation of PMNLs by PMA, ionophore or fMet-Leu-Phe thus leads to the sustained production of DAG accompanied by the disappearance of phosphorylcholine. This suggests that these stimulants enhance PC turnover via a hydrolytic mechanism which is independent of phospholipase C, with activation of a PC-specific phospholipase D being a plausible mechanism.
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Hu, Xichun, Jian Zhang, Rujiao Liu, Shuiping Gao, Yan Qing, Shuli Yi, Juanjuan Yuan et al. "Phase I study of A166 in patients with HER2-expressing locally advanced or metastatic solid tumors." Journal of Clinical Oncology 39, n. 15_suppl (20 maggio 2021): 1024. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1024.
Abstract (sommario):
1024 Background: A166 is an antibody-drug conjugate composed of a novel cytotoxic drug (Duo-5, anti-microtubule agent) site-specifically conjugated to an anti-HER2 antibody (transtuzumab) via a stable protease-cleavable valine citrulline linker. In a phase I trial in US patients (pts) with relapsed or refractory advanced solid tumor, A166 had an acceptable toxicity profile and best objective response rate (ORR) of 36% at efficacious dose levels (Yongheng Liu et al. ASCO 2020). Here we report a phase I study of A166 in Chinese pts with locally advanced or metastatic solid tumors (CTR20181301). Methods: KL166-I-01-CTP is a single arm, open-label, dose-escalation and dose-expansion phase I study evaluating A166 in pts with HER2-expressing locally advanced or metastatic solid tumors. Pts received A166 at doses of 0.1, 0.3, 0.6, 1.2, 2.4, 3.6, 4.8, 6.0 mg/kg IV Q3W. Dose cohorts were expanded at 4.8 and 6.0 mg/kg Q3W. The objectives were to determine the safety and tolerability, pharmacokinetics and antitumor activity of A166. Results: 57 pts (median age 53 [range 26-74], 50 female, 7 male) enrolled from Aug 1, 2018 to Nov 30, 2020. HER2 expression was available for all 57 pts: 51 HER2-positive (3+ or 2+/ISH+), 6 HER2-low (1+ or 2+/ISH-). 61.4% (35/57) had received ≥5 prior lines of therapy. No DLTs were observed in all dose groups. Any grade treatment-related AEs (TRAEs) were documented in 96.5% (55/57) of pts, with 31.6% (18/57) being grade 3 or higher. Common TRAEs were corneal epitheliopathy (73.7%), vision blurred (59.6%), peripheral sensory neuropathy (26.3%), dry eye (21.1%), anemia (19.3%), hyponatremia (19.3%). Most common grade ≥3 TRAEs were corneal epitheliopathy (17.5%), hypophosphatemia (5.3%), and dry eye (5.3%). Four pts had serious AEs, two of which were possibly related to the study drug, including thrombosis and fatigue. TRAEs led to 5.3% (3/57) dose reduction and 5.3% (3/57) treatment discontinuation. One death occurred during the treatment due to progressive disease. At the doses of 0.3-6.0 mg/kg, the exposure of ADC in serum were dose dependent and the mean half-life was found to be 1.17-11.04 days. Serum free toxins was about 0.1% and 0.2% of total A166 (ADC) on a molar basis with the Cycle 1 Cmax and AUC, respectively. At efficacious dose, 36 HER2-positive breast cancer pts with measurable disease were assessed for efficacy, best ORR were 59.1% (13/22) and 71.4% (10/14) in 4.8 and 6.0 mg/kg cohort, respectively. Median progression-free survival (PFS) was not reached, and one patient in 4.8 mg/kg cohort has undergone the treatment for more than 19 months. Conclusions: A166 had a manageable safety profile and high stability in the circulation with much lower acute hematological and gastrointestinal toxicities in terms of incidence rate and grade. It demonstrated promising antitumor activity with clinically meaningful responses in heavily pretreated subjects with HER2-positive breast cancer. Clinical trial information: CTR20181301 .
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Walsh, Kimberly D., Nader Soltani, David C. Hooker, Robert E. Nurse e Peter H. Sikkema. "Biologically effective rate of sulfentrazone applied pre-emergence in soybean". Canadian Journal of Plant Science 95, n. 2 (marzo 2015): 339–44. http://dx.doi.org/10.4141/cjps-2014-264.
Abstract (sommario):
Walsh, K. D., Soltani, N., Hooker, D. C., Nurse, R. E. and Sikkema, P. H. 2015. Biologically effective rate of sulfentrazone applied pre-emergence in soybean. Can. J. Plant Sci. 95: 339–344. Sulfentrazone is a protoporphyrinogen (PPO)-inhibiting herbicide under evaluation for use in soybean in Ontario, Canada. The primary objective of this study was to determine the dose of sulfentrazone applied pre-emergence (PRE) needed to provide 50 and 90% control of redroot pigweed, common ragweed, common lambsquarters and green foxtail. Seven field trials were conducted over a 3-yr period (2007, 2008 and 2009) in southwestern Ontario to evaluate the efficacy of sulfentrazone applied PRE at doses ranging from 26 to 1120 g a.i. ha−1. The doses of sulfentrazone applied PRE to reduce redroot pigweed, common ragweed, common lambsquarters and green foxtail dry weight by 50% were 104, 139, 15 and 65 g a.i. ha−1; doses of 241, 514, 133 and 721 g a.i. ha−1 of sulfentrazone were required for 90% reduction in above-ground biomass of those weed species, respectively. Sulfentrazone applied PRE caused soybean injury only at 560 and 1120 g a.i. ha−1, with 6 and 13% soybean injury at 4 wk after herbicide application (WAT), respectively. Weed control provided by sulfentrazone applied PRE at a dose of 600 g a.i. ha−1 was sufficient to maintain 90% of the soybean yield compared with the weed-free control. Therefore, PRE application of sulfentrazone has the potential to provide excellent (>90%) control of selected weeds with minimal to no crop injury; however, weed control varied by species, and thus broad spectrum weed control is not feasible using sulfentrazone alone.
27
Jeong, Ka Yeon, Claudio Pasian e David Tay. "(125) Response of Six Begonia Species to Different Substrate pH". HortScience 40, n. 4 (luglio 2005): 1085C—1085. http://dx.doi.org/10.21273/hortsci.40.4.1085c.
Abstract (sommario):
Substrate pH of soilless media directly affects nutrient availability. Limited information about the effect of substrate pH on growth of begonia species (not cultivated hybrids) was found in the literature. The objective of this study was to evaluate the effect of substrate pH on the growth and quality of six begonia species grown from June to Aug. 2004. The targeted pH ranges (<4.5, 4.5∼5.0, 5.0∼5.5, 5.5∼6.0, 6.0∼6.5, 6.5∼7.0, and over 7.0) of the peat-based substrates were obtained by adding seven different amounts of dolomitic hydrated lime: 0, 1.0, 1.3, 1.6, 2.0, 2.4, and 2.6 kg·m3. Begonia albopicta, B. cucullata var. cucullata, B. echinosepala var. elongatifolia, B. holtonis, B. fuchsioides (red), and B. fuchsioides (pink), were propagated by stem cuttings, and then transplanted into plastic containers. This experiment was a factorial experiment arranged in a randomized complete-block design. The pH was monitored weekly using the pour-through method and adjusted accordingly by adding flowable lime or a mild sulfuric acid solution. The pH values were averaged for each treatment of each species. There were significant differences between species in the inflorescence number and SPAD readings, but no interaction between species and substrate pH was found. Stem length, leaf area, and dry weight of each plant were significantly affected by species and substrate pH. B. albopicta performed best at substrate pH of 5.6 and 6.0, showing no symptoms of phytotoxicity. B. cucullata, above substrate pH 6.0, and B. holtonis at pH 5.0 and 5.6 had the highest vegetative growth and plant quality. Plant mortality was observed for B. cucullata and B. fuchsioides (red) at pH below 4.4 and 5.3, respectively.
28
Wise, R., T. Gee, G. Marshall e J. M. Andrews. "Single-Dose Pharmacokinetics and Penetration of BMS 284756 into an Inflammatory Exudate". Antimicrobial Agents and Chemotherapy 46, n. 1 (gennaio 2002): 242–44. http://dx.doi.org/10.1128/aac.46.1.242-244.2002.
Abstract (sommario):
ABSTRACT The pharmacokinetics of a single dose of BMS 284756 were determined following oral administration of a 600-mg dose to eight healthy male volunteers. Concentrations of the drug were measured in plasma and a cantharidine-induced inflammatory exudate by a microbiological assay. The mean peak concentration in plasma of 10.4 μg/ml (standard deviation [SD], 1.3 μg/ml) was attained at a mean time of 1.2 h (SD, 0.5 h) after the dose. The penetration into the inflammatory exudate was 82% (SD, 15.7%). A mean peak concentration of 7.2 μg/ml (SD, 2.4 μg/ml) was attained in the inflammatory exudate at 5.3 h (SD, 1.5 h). The elimination half-lives from plasma and inflammatory fluid were 9.8 h (SD, 1.1 h) and 8.5 h (SD, 1.9 h), respectively. The areas under the concentration-time curves for plasma and inflammatory fluid were 96.7 μg · h/ml (SD, 10.3 μg · h/ml) and 77.9 μg · h/ml (SD, 19.2 μg · h/ml), respectively.
29
Akman, A., O. Oram e P. Aydin. "Optic Disc Measurements with the 78 Diopter Lens, Zeiss 4-Mirror Contact Lens and Computerized Image Analysing System". European Journal of Ophthalmology 8, n. 1 (gennaio 1998): 22–27. http://dx.doi.org/10.1177/112067219800800106.
Abstract (sommario):
We evaluated the 78 diopter (D) lens and Zeiss 4-mirror lens for the measurement of vertical and horizontal optic disc diameters during slit-lamp biomicroscopy and compared the results with the measurements made with the computerized image analysing system (IMAGEnet 640, Topcon, Japan) in 30 eyes of 30 patients. The 78D lens and Zeiss 4-mirror lens measurements both correlated well with the computerized image analysis measurements (r=0.881 for vertical and r=0.895 for horizontal disc diameter measurements with the 78D lens and r=0.883 for vertical and r=0.891 for horizontal disc diameter measurements with the Zeiss 4-mirror lens). The 78D lens measurements overestimated vertical disc diameter by 5.3% and horizontal disc diameter by 4.4%. The Zeiss 4-mirror lens underestimated the vertical disc diameter by 2.4% and horizontal disc diameter by 2.2%. Thus either lens can be used for a quick estimation of the optic disc size, since the results correlate well with the computerized image analysis measurements.
30
Balla, József, György Balla, Viktoria Jeney, György Kakuk, Harry S. Jacob e Gregory M. Vercellotti. "Ferriporphyrins and endothelium: a 2-edged sword—promotion of oxidation and induction of cytoprotectants". Blood 95, n. 11 (1 giugno 2000): 3442–50. http://dx.doi.org/10.1182/blood.v95.11.3442.011k51_3442_3450.
Abstract (sommario):
Heme arginate infusions blunt the symptoms of patients with acute intermittent porphyria without evidence of the vascular or thrombotic side effects reported for hematin. To provide a rationale for heme arginate's safety, the present study examined the effects of various ferriporphyrins to sensitize human endothelial cells to free radical injury and to induce heme oxygenase and ferritin expression. Heme arginate, unlike hematin, did not amplify oxidant-induced cytotoxicity mediated by hydrogen peroxide (5.3 ± 2.4 versus 62.3 ± 5.3% 51Cr release,P < .0001) or by activated neutrophils (14.4 ± 2.9 versus 41.1 ± 6.0%, P < .0001). Nevertheless, heme arginate efficiently entered endothelial cells similarly to hematin, since both markedly induced heme oxygenase mRNA (more than 20-fold increase) and enzyme activity. Even with efficient permeation, endothelial cell ferritin content was only minimally increased by heme arginate compared with a 10-fold induction by hematin; presumably less free iron was derived from heme arginate despite up-regulation of heme oxygenase. Hematin is potentially vasculopathic by its marked catalysis of oxidation of low-density lipoprotein (LDL) to endothelial-toxic moieties. Heme arginate was significantly less catalytic. Heme arginate–conditioned LDL was less than half as cytotoxic to endothelial cells as hematin-conditioned LDL (P < .004). It is concluded that heme arginate may be less vasculotoxic than hematin since it is an effective heme oxygenase gene regulator but a less efficient free-radical catalyst.
31
Vyayzenen, G., R. Dautov, A. Vyayzenen, D. Bolshakov e N. Prodanov. "Vitamin nutrition of calves". Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), n. 3 (1 marzo 2020): 25–36. http://dx.doi.org/10.33920/sel-05-2003-03.
Abstract (sommario):
Experimental studies have shown an increase in productivity, metabolic processes, the effectiveness of the use of nutrients and biologically active substances and the metabolic energy of diets, the health of heifers aged 1–6 months under the conditions of industrial technology of their rearing. Increasing the productivity of heifers is closely related to improving the nutrition system during all periods of rearing with the use of the vitamin complex Vitaminol in diets depending on their age and body weight. The highest effectiveness of rearing young animals has been established when using Vitaminol in doses: 1,3 g/head./day – up to 1 month, 2,4 g/head./day – 2 months, 3,3 g/head./day – 3 months, 4,3 g/head./day – 4 months, 4,8 g/head./day – 5 months and 5,3 g/head./day – at the age of 6 months. Differentiated feeding of optimal doses of feed additives to calves increases the digestibility of dry matter by 1,41–10,8 %, organic matter by 1,6–10,0 %, raw protein by 1,6–6,8 %, raw fat by 1,4–8,7 %, raw fiber by 1,5–3,0 % and nitrogen-free extractive substances by 1,6–6,0 % depending on age and body weight (from 1 to 6 months inclusive). It has a positive effect on the absorption of nitrogen and the use of calcium and phosphorus in the body. The use of Vitaminol in diets of calves contributes to an increase in live weight and average daily gain compared to the control group. In calves up to one month of age (at the dose of 1,3 g/head/day) live weight increased by 6,5 %, the average daily gain by 11,4 %, in 2 months (at the dose of 2,4 g/head/day) these indicators were 2,9 and 2,6 %, respectively, at 3 months (at the dose of 3,3 g/head/day) – 3,4 and 8,2 %, in 4 months (at the dose of 4,3 g/head/day) – 6,7 and 12,8 %, in 5 months (at the dose of 4,8 g/head/day) – 4,4 and 3,6 % and at 6 months (at the dose of 5,3 g/head/day) – 4,3 and 2,7 %, respectively. In order to improve the quality of feeding when rearing calves, more fully realize their genetic potential, increase productivity and use of nutrients in diets and normalize metabolic processes in the body we recommend the optimal doses of the feed additive Vitaminol depending on age (g/head/day): 1,3 – in 1 month, 2,4 – in 2 months, 3,3 – in 3 months, 4,3 – in 4 months, 4,8 – in 5 months, 5,3 – in 6 months. Feed additive Vitaminol enter into the composition of complete feed, wet feed mixtures and feed to calves 1 time per day.
32
Todd-Brown, K. E. O., J. T. Randerson, W. M. Post, F. M. Hoffman, C. Tarnocai, E. A. G. Schuur e S. D. Allison. "Causes of variation in soil carbon predictions from CMIP5 Earth system models and comparison with observations". Biogeosciences Discussions 9, n. 10 (18 ottobre 2012): 14437–73. http://dx.doi.org/10.5194/bgd-9-14437-2012.
Abstract (sommario):
Abstract. Stocks of soil organic carbon represent a large component of the carbon cycle that may participate in climate change feedbacks, particularly on decadal and century scales. For Earth system models (ESMs), the ability to accurately represent the global distribution of existing soil carbon stocks is a prerequisite for predicting future carbon-climate feedbacks. We compared soil carbon predictions from 16 ESMs to empirical data from the Harmonized World Soil Database (HWSD) and Northern Circumpolar Soil Carbon Database (NCSCD). Model estimates of global soil carbon stocks ranged from 510 to 3050 Pg C, compared to an estimate of 890–1660 Pg C from the HWSD. Model predictions for the high latitudes fell between 60 and 800 Pg C, compared to 380–620 Pg C from the NCSCD and 290 Pg C from the HWSD. This 5.3-fold variation in global soil carbon across models compared to a 3.4-fold variation in net primary productivity (NPP) and a 3.8-fold variation in global soil carbon turnover times. The spatial distribution of soil carbon predicted by the ESMs was not well correlated with the HWSD (Pearson's correlations < 0.4, RMSE 9.4 to 22.8 kg C m−2), although model-data agreement generally improved at the biome scale. There was poor agreement between the HWSD and NCSCD datasets in northern latitudes (Pearson's correlation = 0.33), indicating uncertainty in empirical estimates of soil carbon. We found that a reduced complexity model dependent on NPP and soil temperature explained most of the spatial variation in soil carbon predicted by most ESMs (R2 values between 0.73 and 0.93). This result suggests that differences in soil carbon predictions between ESMs are driven primarily by differences in predicted NPP and the parameterization of soil carbon responses to NPP and temperature not by structural differences between the models. Future work should focus on accurately representing these driving variables and modifying model structure to include additional processes.
33
Giai, Valentina, Stefania Tamiazzo, Sabrina Leoncino, Lia Mele, Maria Matilde Ciriello, Federico Monaco, Elisa Bernocco et al. "Graft Purity and Composition Significantly Impact the Engraftment of Autologous Stem Cell Transplants". Blood 128, n. 22 (2 dicembre 2016): 5733. http://dx.doi.org/10.1182/blood.v128.22.5733.5733.
Abstract (sommario):
Abstract Background: Autologous stem cell transplantation (ASCT) has been widely used in the treatment of hematological malignancies over the last two decades. Despite its broad use, some characteristics that might influence engraftment have not been exhaustively investigated, particularly graft purity with respect to contamination by platelets (PLTS) and White Blood Cells (WBC). Here we report collection characteristics and engraftment kinetics of a single Center consecutive series of 510ASCTs. Methods: We retrospectively collected clinical records of patients who underwentleucapheresis procedures (LA; followed or not byASCT) at our Institution over 16 years (2000-2016): 290 patients collected peripheral blood stem cells (PBSC) (80 Multiple Myeloma MM, 133 Non Hodgkin Lymphoma NHL, 22 Hodgkin Lymphoma HL, 32 Acute Myeloid Leukemia AML, 23 other diseases) for a total of 481LAs. Mobilizing regimens are described in Table 1. We considered the number of harvested CD34+ cells *106/kg the first day of LA. Data on 458 patients (191 MM, 190 NHL, 45 HL, 19 AML and 13 other diseases) for a total of 510 ASCTs were acquired. The impact on engraftment kinetics of conditioning chemotherapies, amount of infused CD34+ cells and WBC/PLTS graft contamination were analyzed. Absolute neutrophil count (ANC) engraftment was defined as the duration of neutropenia (from day 0 to the first of 3 consecutive days of ANC>500/ul post ASCT). Results: Regarding CD34+ cell collection, no impact of mobilizing regimens and WBC count during LA was observed. On the other hand, we observed a difference in the number of total CD34+ cells collected among different diagnoses: the median overall collection was 7.2 (0.65-64.06)*106/kg CD34+ cells for NHL patients, 5.66 (0.71-23.31)*106/kg for MM patients, 6.15 (0.51-23.24) *106/kg for HL patients and 3.56 (0.64-20.3)*106/kg for AML patients) (p = 0.001). Considering CD34+ cells/kg harvested on the first day of LA, 59.2% of NHL and HL, 57.5% of MM patients and 34% of AML patients harvested ³ 5*106/Kg CD34+ cells. Of note, among AML patients, 40.6% collected less than 2.5*106/kg. The differences were statistically significant (p = 0.003) (Tab. 2). Moreover, an inverse correlation between collected CD34+ cells and age was shown (p = 0.001) (Fig.1). ANC recovery after ASCTwas not influenced by conditioning regimen whereas diagnosis impacted on the duration of neutropenia (AML patients displayed a longer aplasia, p < 0.01). We observed that the median days with ANC<500/ul were 10, 11 and 12 in patients who received >5.3*10^6/kg, 3.5-5.3*10^6/kg and <3.5*10^6/kg CD34+ cells, respectively (p <0.0001) (Fig 2a). Furthermore, the same finding was observed considering the duration of thrombocytopenia (median number of days with PLTS <50000/ul: 15, 18 and 20 in patients who received >5.3*10^6/kg, 3.5-5.3*10^6/kg and <3.5*10^6 CD34+ cells, p<0.0001) (Fig.2b). Looking at the apheresis product, we analyzed the impact of harvest contaminating WBC and PLTSon engraftment kinetics. Notably, when the ASCTcollection contained >100*103/ul WBC, ANC engraftment (days with ANC < 500/ul) lasted longer (median days 11) compared to patients who received a graft with lower WBC count (p < 0.0001) (Fig. 3a). A faster ANC engraftment was also observed in patients receiving harvests with PLTS levels >600*103/ul compared to those who infused a collection bag with PLTS <600*103/ul (p = 0.005) (Fig.3b,c). Conclusions: Herein, we confirmed that the disease and the amount of infusedCD34+ cells significantly influence time of ANC andPLTS engraftment; furthermore, we observed for the first time that quality and purity of the graft have a substantial impact on engraftment kinetics. Disclosures No relevant conflicts of interest to declare.
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Weltman, Arthur, Cathy J. Pritzlaff, Laurie Wideman, Judy Y. Weltman, Jeffery L. Blumer, Robert D. Abbott, Mark L. Hartman e Johannes D. Veldhuis. "Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow". Journal of Applied Physiology 89, n. 2 (1 agosto 2000): 629–35. http://dx.doi.org/10.1152/jappl.2000.89.2.629.
Abstract (sommario):
To test the hypothesis that heightened sympathetic outflow precedes and predicts the magnitude of the growth hormone (GH) response to acute exercise (Ex), we studied 10 men [age 26.1 ± 1.7 (SE) yr] six times in randomly assigned order (control and 5 Ex intensities). During exercise, subjects exercised for 30 min (0900–0930) on each occasion at a single intensity: 25 and 75% of the difference between lactate threshold (LT) and rest (0.25LT, 0.75LT), at LT, and at 25 and 75% of the difference between LT and peak (1.25LT, 1.75LT). Mean values for peak plasma epinephrine (Epi), plasma norepinephrine (NE), and serum GH concentrations were determined [Epi: 328 ± 93 (SE), 513 ± 76, 584 ± 109, 660 ± 72, and 2,614 ± 579 pmol/l; NE: 2.3 ± 0.2, 3.9 ± 0.4, 6.9 ± 1.0, 10.7 ± 1.6, and 23.9 ± 3.9 nmol/l; GH: 3.6 ± 1.5, 6.6 ± 2.0, 7.0 ± 2.0, 10.7 ± 2.4, and 13.7 ± 2.2 μg/l for 0.25, 0.75, 1.0, 1.25, and 1.75LT, respectively]. In all instances, the time of peak plasma Epi and NE preceded peak GH release. Plasma concentrations of Epi and NE always peaked at 20 min after the onset of Ex, whereas times to peak for GH were 54 ± 6 (SE), 44 ± 5, 38 ± 4, 38 ± 4, and 37 ± 2 min after the onset of Ex for 0.25–1.75LT, respectively. ANOVA revealed that intensity of exercise did not affect the foregoing time delay between peak NE or Epi and peak GH (range 17–24 min), with the exception of 0.25LT ( P < 0.05). Within-subject linear regression analysis disclosed that, with increasing exercise intensity, change in (Δ) GH was proportionate to both ΔNE ( P = 0.002) and ΔEpi ( P = 0.014). Furthermore, within-subject multiple-regression analysis indicated that the significant GH increment associated with an antecedent rise in NE ( P = 0.02) could not be explained by changes in Epi alone ( P = 0.77). Our results suggest that exercise intensity and GH release in the human may be coupled mechanistically by central adrenergic activation.
35
Tsao, Bang Hung, Jacob Lawson, James D. Scofield, Clinton Laing e Jeffery Brown. "3D Thermal Stress Model for SiC Power Modules". Materials Science Forum 600-603 (settembre 2008): 1227–30. http://dx.doi.org/10.4028/www.scientific.net/msf.600-603.1227.
Abstract (sommario):
Three dimensional models of both single-chip and multiple-chip power sub-modules were generated using ANSYS in order to simulate the effects of various substrate materials, heat fluxes, heat transfer coefficients, and device placement configurations on temperature and thermal stress contours. Alumina, aluminum-nitride, and CVD diamond were compared as substrates. Heat fluxes of 100 to 500 watts/cm2 resulted in SiC device junction temperatures in the range of 350 to 650 K. The predicted maximum operating temperature for a chip, to which 300 watts/cm2 of heat flux was applied, would be 239°C (512 K). In the applied heat flux range, the minimum and maximum Von Mises stress of a simulated single SiC device sub-module was between 1.2 MPa to 2.4 GPa. The maximum shear stress at 300 watts/cm2 was predicted to be 243 MPa. Both the maximum and minimum chip temperature decreased with increasing heat transfer coefficient from 25 to 2500 watts/m2 K. With modest cooling, represented by a heat transfer coefficient (hconv) of 250 watts/m2 K, SiC chips operated at 300 watts/cm2 power density maintained junction temperatures Tj < 400 K. If consistent with simulation results, CVD diamond integrated substrates should be superior to those comprised of AlN or Al2O3. Asymmetric device placement in the multi-chip module proved more effective at avoiding potential hot spots than the symmetric configuration.
36
Balla, József, György Balla, Viktoria Jeney, György Kakuk, Harry S. Jacob e Gregory M. Vercellotti. "Ferriporphyrins and endothelium: a 2-edged sword—promotion of oxidation and induction of cytoprotectants". Blood 95, n. 11 (1 giugno 2000): 3442–50. http://dx.doi.org/10.1182/blood.v95.11.3442.
Abstract (sommario):
Abstract Heme arginate infusions blunt the symptoms of patients with acute intermittent porphyria without evidence of the vascular or thrombotic side effects reported for hematin. To provide a rationale for heme arginate's safety, the present study examined the effects of various ferriporphyrins to sensitize human endothelial cells to free radical injury and to induce heme oxygenase and ferritin expression. Heme arginate, unlike hematin, did not amplify oxidant-induced cytotoxicity mediated by hydrogen peroxide (5.3 ± 2.4 versus 62.3 ± 5.3% 51Cr release,P < .0001) or by activated neutrophils (14.4 ± 2.9 versus 41.1 ± 6.0%, P < .0001). Nevertheless, heme arginate efficiently entered endothelial cells similarly to hematin, since both markedly induced heme oxygenase mRNA (more than 20-fold increase) and enzyme activity. Even with efficient permeation, endothelial cell ferritin content was only minimally increased by heme arginate compared with a 10-fold induction by hematin; presumably less free iron was derived from heme arginate despite up-regulation of heme oxygenase. Hematin is potentially vasculopathic by its marked catalysis of oxidation of low-density lipoprotein (LDL) to endothelial-toxic moieties. Heme arginate was significantly less catalytic. Heme arginate–conditioned LDL was less than half as cytotoxic to endothelial cells as hematin-conditioned LDL (P < .004). It is concluded that heme arginate may be less vasculotoxic than hematin since it is an effective heme oxygenase gene regulator but a less efficient free-radical catalyst.
37
Puxeddu, Mariano. "Interaction of B-rich supercritical magmatic fluids with granite: first report of dumortierite in a geothermal field, Larderello, Italy". South Florida Journal of Development 3, n. 3 (4 maggio 2022): 3162–69. http://dx.doi.org/10.46932/sfjdv3n3-009.
Abstract (sommario):
In a peraluminous two-mica monzogranite cored at 4.5 km depth in well Radicondoli 29, dumortierite occurs together with andalusite, Li-rich tourmaline, fluorite and fluorapatite. The average composition is SiO2: 30.9, Al2O3: 58.6, FeO: 0.44, MgO: 0.47, CaO: 0.02, F: 0.15. Dumortierite crystallized from supercritical magmatic fluids at T =520-620°C, P = 100 ± 30 MPa. Synthetic fluid inclusions yielded T = 510 ± 10 MPa, P = 42 ± 3 MPa at 2.9 km depth in well Venelle 2. Al data suggest present day T = 450-550°C, P = 40-80 MPa. The supercritical magmatic fluids were hypersaline brines with ~ 30 wt % LiCl and up to 2.4 wt % F, extreme contents that can be found only in pegmatites, aplites and leucogranites. Larderello granites derived from partial melting of a lower crust made up of interlayered metasediments and amphibolites. Extensive melting took place in the lower crust during the last 10 Ma owing to extensional tectonics, lithosphere thinning, roll back or break down of the west merging Adria plate and swelling of the asthenosphere below the western side of the Apennines.
38
Puxeddu, Mariano. "Interaction of B-rich supercritical magmatic fluids with granite: first report of dumortierite in Larderello, Italy". E3S Web of Conferences 98 (2019): 01042. http://dx.doi.org/10.1051/e3sconf/20199801042.
Abstract (sommario):
In a peraluminous two-mica monzogranite cored at 4.5 km depth in well Radicondoli 29, dumortierite occurs together with andalusite, Li-rich tourmaline, fluorite and fluorapatite. The average composition is SiO2: 30.9, Al2O3: 58.6, FeO: 0.44, MgO: 0.47, CaO: 0.02, F: 0.15. Dumortierite crystallized from supercritical magmatic fluids at T =520-620°C, P = 100 ± 30 MPa. Synthetic fluid inclusions yielded T = 510 ± 10°C, P = 42 ±3 MPa at 2.9 km depth in well Venelle 2. All data suggest present-day T = 450-550°C, P = 40-80 MPa. The supercritical magmatic fluids were hypersaline brines with ~ 30 wt % LiCl and up to 2.4 wt % F, extreme contents that can be found only in pegmatites, aplites and leucogranites. Larderello granites derived from partial melting of a lower crust made up of interlayered metasediments and amphibolites. Extensive melting took place in the lower crust during the last 10 Ma owing to extensional tectonics, lithosphere thinning, roll back or break down of the west merging Adria plate and swelling of the asthenosphere below the western side of the Apennines.
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Sartori Dameto, Larissa, Francisco Carlos Krzyzanowski, Marco Eustáquio de Sá, Adonis Moreira e Larissa Alexandra Cardoso Moraes. "DESEMPENHO FISIOLÓGICO DE SEMENTES DE CULTIVARES SOJA CONVENCIONAL EM FUNÇÃO DO TAMANHO E TEOR DE UMIDADE NA GERMINAÇÃO". BRAZILIAN JOURNAL OF AGRICULTURE - Revista de Agricultura 98, n. 2 (27 settembre 2023): 119–31. http://dx.doi.org/10.37856/bja.v98i2.4330.
Abstract (sommario):
Quality test protocols for soybean seeds recommend a period of soaking and preconditioning without detailing the size of the seeds to be evaluated, as seeds of different sizes reach different degrees of humidity in each period owing to differences in their initial moisture level and size. Determining the degree of seed moisture during the preconditioning period is important when conducting accelerated aging, tetrazolium, and primary root protrusion tests. The objective of this study was to evaluate the physiological performance of two conventional soybean cultivars (BRS 284 and BRS 511) with three seed sizes (6.0, 6.5, and 7.0 mm) and three moisture levels, adjusted to 10%, 12%, and 14% and a control condition with 8.8% moisture. The experimental design was a randomized block scheme in a factorial arrangement of (3×3)+1 involving seed size and moisture. Regardless of the cultivar and moisture content, seeds with large diameters were more resistant to changes, such as accelerated aging, and resulted in larger seeds and higher numbers of developed seedlings than seeds with small diameters.
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Marincowitz, Carl, Omar Bouamra, Tim Coates, Dhushy Kumar, David Lockey, Virginia Newcombe, Lyndon Mason, David Yates, Julian Thompson e Fiona Lecky. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals". Emergency Medicine Journal 39, n. 12 (22 novembre 2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.
Abstract (sommario):
Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics, injury mechanism, severity, treatment and outcomes of major trauma in England.Method and DesignDemographic characteristics and clinical pathways of TARN eligible patients in the first lockdown (24th March to 3rd July 2020 inclusive) and second lock down (1st November 2020 to 16th May 2021 inclusive) were compared to equivalent pre-COVID-19 periods in 2018–2019.A segmented regression model predicting the weekly risk adjusted survival was estimated and a discontinuity in the gradient (trend) or intercept (level) of the fitted model was tested for at the weekly time point of implementation of each lockdown.Abstract 1427 Figure 1Strobe diagram for inclusion of study populationAbstract 1427 Figure 2Interrupted time series analysis assessing the impact of COVID restrictions on likelihood of survival (red horizontal lines indicate introduction and relaxation of ‘lockdown’ measures)Abstract 1427 Table 1Comparison of demographics ‘lockdown’ and pre-COVID periodsPeriodPeriod24Mar19 – 03Jul19 (comparator)24Mar20 – 03Jul20 (lockdown 1)Absolute change [percentage point change (95%CI)] p-value01Nov18 – 16May19 (comparator)01Nov20 – 16May21 (lockdown 1)Absolute change [percentage point change (95%CI)] p-valueTotal2224317510-4733 (-21%)p<0.0001‡41016382622754 (–6.7%)p<0.0001‡Age (years), Median (IQR)67.6 (46.5–83.1)70.9 (50.3–84.2)3.3 (2.4 to 4.2)p<0.000169.1 (48.7–83.6)73.1 (53.3–85.1)4 (3.5 to 4.2)<0.0001Age bands, n(%)Age< 1138 (0.6%)130 (0.7%)-8 [0.1(-0.04 to 0.030)] p=0.14281 (0.7%)234 (0.6%)-47 [0.1 (-0.2 to 0.04)]p=0.1979Age <16942 (4.2%)674 (3.8%)-268 [-0.4 (-0.8 to 0]p=0.05311444 (3.5%)1218 (3.2%)-226 [-0.3(-0.6 to – 0.1)p=0.0084Age 16 – 649561 (43%)6974 (39.8%)-2587 [-3.2(-4.1 to -2.2)P<0.000117173 (41.9%)13980 (36.5%)-3193 [-5.3(-6 to -5)]p<0.0001Age 65 and over11740 (52.8%)9862 (56.3%)-1878 [3.5 (2.5 to 4.5)]p<0.000122399 (54.6%)23064 (60.3%)665 [5.7(5 to 6.3)]P<0.0001Age 85 and over4610 (20.7%)4047 (23.1%)-563 [2.4(1.6 to 3.2)]p<0.00018903 (21.7%)9731 (25.4%)828 [3.7 (3.1 to 4.3)]p<0.0001Male, n(%)12316 (55.4%)9512 (54.3%)-2804 [-1 (-2 to -0.6)]p=0.037322146 (54%)19769 (51.7%)-2377 [-2.3 (-3 to -1.6)]<0.0001CCI*, n(%)CCI 09359 (42.1%)6220 (35.5%)-3139 [ -6.5 (-7.5 to -5.6)] p<0.000116665 (40.6%)12806 (33.5%)-3859 [-7.1(-7.8 to -6.5)]p<0.0001CCI 1 – 58538 (38.4%)6896 (39.4%)-1642 [1 (0.3 to 2)]p=0.042615899 (38.8%)15667 (40.9%)-232 [2.2 (1.5 to 2.9)]p<0.0001CCI 6 – 103032 (13.6%)3061 (17.5%)29 [3.8 (3.2 to 4.6)]p<0.00015987 (14.6%)6863 (17.9%)876 [3.3(2.8 to 3.8)]p<0.0001CCI > 10927 (4.2%)1024 (5.8%)97 [1.7(1.2 to 2.1)]p<0.00011648 (4%)2410 (6.3%)762 [2.3(2 to 2.6)]p<0.0001Not recorded387 (1.7%)309 (1.8%)-88 [0.2 (-0.2 to 0.3)]p=0.8513817 (2%)516 (1.3%)-301 [-0.6(-0.8 to -0.5)]p<0.0001MOI**: RTC, n(%)Car occupant1247 (30.7%)551 (20.4%)-696 [-10.4(-12.4 to -8.2)]p<0.00012485 (35.2%)1551 (31.3%)-934 [-3.9(-5.6 to -2.2)]p<0.0001Pedestrian661 (16.3%)288 (10.6%)-373 [-5.6 (-7.2 to -4)]p<0.00011629 (23.1%)962 (19.4%)-667 [-3.7(-5.1 to -2.2)]p<0.0001Motorcycles1196 (29.4%)711 (26.3%)-485 [-3.2(-5.3 to -1)]p<0.00011524 (21.6%)976 (19.7%)-548[ -1.9(-3.3 to -0.4)]p<0.0001Cyclist912 (22.4%)1139 (42.1%)227 [19.6(17.4 to 21.9)]p<0.00011315 (18.6%)1396 (28.2%)81 [9.5(8 to 11.1)]p<0.0001Other11 (0.3%)<9 ()-10 [ -0.2(-0.4 to -0.06)p=0.025131 (0.4%)10 (0.2%)-21 [-0.23(-0.4 to -0.04)]p=0.0281MOI: Intentional, n(%)Intentional assault130 (0.6%)88 (0.5%)-42 [-0.08 (-0.2 to 0.06)]p=0.2724227 (0.6%)175 (0.5%)-52 [-0.1(-0.2 to 0.002)]P=0.0570Self harm276 (1.2%)284 (1.6%)8 [0.4 (0.1 to 0.6)]p=0.0014525 (1.3%)562 (1.5%)37 [0.2 (0.02 to 0.3)]p=0.0223NAI63 (0.3%)27 (0.2%)-36 [-0.1(-0.2 to -0.03)]p=0.007297 (0.2%)90 (0.2%)-7 [-0.001(-0.07 to 0.07)]p=0.9701Shooting34 (0.2%)40 (0.2%)6 [0.08(-0.01 to 0.2)]p=0.082680 (0.2%)56 (0.1%)-24 [ -0.05(-0.1 to 0.001)]p=0.0979Stabbing450 (2%)312 (1.8%)-138 [-0.2(-0.5 to 0.03)]p=0.0816791 (1.9%)589 (1.5%)-202 [-0.4 (-0.6 to -0.2)]p<0.0001Blows1174 (5.3%)647 (3.7%)-527 [-1.6(-1.9 to -1.2)]p<0.00012059 (5%)1299 (3.4%)-760 [-1.6(-1.9 to -1.3)]p<0.0001Unintentional, n(%)Falls>2m2055 (9.2%)1757 (10%)-298 [0.8(0.2 to 1.4)]P=0.00753740 (9,1%)3528 (9.2%)-212 [0.1(-0.3 to 0.5)]p=0.6181Falls<2m13384 (60.2%)11314 (64.6%)-2070 [4.4 (3.5 to 5.4)]p<0.000125505 (62.2%)26203 (65.8%)698 [6.3 (5.6 to 6.9)]p<0.0001Sport449 (2%)320 (1.8%)-129 [-0.2 (-0.5 to 0.01]p=0.1697615 (1.5%)489 (1.3%)-126 [-0.2 (-0.4 to -0.006)]p=0.0079GCS bands , n(%)Mild19609 (88.2%)15449 (88.2%)4160 [0.1 (-0.6 to 0.7)]p=0.826435831 (87.4%)34051 (89%)-1780 [1.6 (1.2 to 2.1)]p<0.0001Moderate689 (3.1%)625 (3.6%)-64 [0.5(0.1 to 0.8)]p=0.00901333 (3.2%)1127 (2.9%)-206 [-0.3 (-0.5 to -0.06)]p=0.0135Severe955 (4.3%)765 (4.4%)-190 [0.1 (-0.3 to 0.5)]p=0.71361886 (4.6%)1464 (3.8%)-422 [-0.8(-1 to -0.5)]p<0.0001Not recorded990 (4.5%)671 (3.8%)-319 [ -0.6(-1 to -0.2)]p=0.00221966 (4.8%)1620 (4.2%)-346 [-0.6(-0.8 to -0.3)]p=0.0002ISS***, median (IQR)9 (9–18)9 (9–18)09 (9–18)9 (9–17)0ISS bands, n(%)ISS 1 – 84545 (20.4%)3062 (17.5%)-1483 [-3 (-4 to -2)]p=<0.00018266 (20.2%)7838 (20.5%)-428 [0.3(-0.2 to 0.9)]p=0.2457ISS 9 – 159290 (41.8%)7728 (44.1%)-1562 [2.4(1.4 to 3.3)]p<0.000117207 (42%)16969 (44.3%)-233 [2.4(1.7 to 3.1)]p<0.0001ISS >158408 (37.8%)6720 (38.4%)-1688 [5.6(-0.4 to 1.5)]p=0.239115543 (37.9%)13455 (35.2%)-2088 [-2.7 (-3.4 to -2)]p<0.0001ISS >253995 (18%)3127 (17.9%)-868 [-0.1(-0.9 to 0.7 )]p=0.79217521 (18.3%)6201 (16.2%)-1320 [-2.1(-2.6 to -1.6)]p<0.0001Body regions, n(%)Head AIS 3+5911 (26.6%)4670 (26.7%)-1241 [0.1 (-0.8 to 1)]p=0.830111128 (27.1%)9629 (25.2%)-1499 [ -2(-2.6 to -1.3)]p<0.0001Face AIS 3+63 (0.3%)41 (0.2%)-22 [-0.05 (-0.1 to 0.05)]p=0.341699 (0.2%)69 (0.2%)-30 [-0.06 (-0.1 to 0)]p=0.0618Chest AIS 3+4787 (21.5%)3915 (22.4%)-872 [8.3 (0.2 to 1.6)]<0.04508515 (20.8%)8075 (21.1%)-440 [0.3 (-0.2 to 0.9)]p=0.2337Abdomen AIS 3+872 (3.9%)690 (3.9%)-182 [0.02 (-0.3 to 0.4)]p=0.91771465 (3.6%)1179 (3.1%)-286 [-0.5 (-0.7 to -0.2)]p=0.0001Spine AIS 3+1985 (8.9%)1561 (8.9%)-424 [-0.01(-0.6 to 0.5)]p=0.97443784 (9.2%)3459 (9%)-325 [-0.2(-0.6 to 0.2)]p=0.3654Pelvis AIS 3+758 (3.4%)600 (3.4%)-158 [0.02(-0.3 to 0.4)]p=0.91841501 (3.7%)1386 (3.6%)-115 [-0.04(-0.3 to 0.2)]p=0.7802Limb AIS 3+5707 (25.7%)4892 (27.9%)-815 [2.3 (1.4 to 3.2)]p<0.000110719 (26.1%)10122 (26.5%)-597 [0.3(-0.3 to 0.9)]p=0.3053Other AIS 3+217 (1%)199 (1.1%)-18 [0.2 (-0.04 to 0.3)]p=0.1176375 (0.9%)396 (1%)21 [0.1 (-0.01 to 0.2]p=0.0836Polytrauma1622 (7.3%)1350 (7.7%)-272 [0.4 (-0.1 to 0.9)]p=0.11602984 (7.3%)2429 (6.3%)-555 [-0.9(-1.2 to 0.6)]p<0.0001*CCI Charlson Comorbidity Index**MOI Mechanism of injury***ISS Injury Severity Score‡chi square test for uniform distributionAbstract 1427 Table 2Comparison care pathways ‘lockdown’ and pre-COVID periodsPeriodPeriod24Mar19 – 03Jul19 (comparator)24Mar20 – 03Jul20 (lockdown 1)Absolute Change01Nov18 – 16May19 (comparator)01Nov20 – 16May21 (lockdown 2)Absolute Change1stHospital MTC9908 (44.5%)7376 (42.1%)-2532 [-2.4 (-3.4 to -1.4)]p<0.000118099 (44.1%)15928 (41.6%)-2171 [-2.5 (-3.2 to -1.8)]p<0.0001Treated at MTC11176 (50.2%)8256 (47.2%)-2920 [-3 (-4 to -2)]p<0.000120395 (49.7%)17852 (46.7%)-2543[-3 (-4 to -2.4)]p<0.0001Consultant ED8140 (36.6%)5562 (31.8%)-2578 [-4.8(-5.8 to -3.9)]p<0.000114779 (36%)12577 (32.9%)-2202 [-3.2 (-3.8 to -2.5)]p<0.0001CT within 1 hr5062 (31.9%)3992 (30.9%)-1070 [-0.9(-2 to 0.1)]p=0.09449203 (31.6%)7776 (27.1%)-1427 [-4(-5 to -3.7)]p<0.0001Whole body CT3348 (15.1%)3210 (18.3%)-138 [3 (2 to 4)]p<0.00016040 (14.7%)6417 (16.8%)377 [2 (1.5 to 2.5)]p<0.0001ICU stay3092 (13.9%)2208 (12.6%)-884 [-1.3(-1.9 to -0.6) ]p=0.00025591 (13.6%)3850 (10.1%)-1741 [-3.6(-4 to -3)]p<0.0001Mortality*1417 (7.1%)1316 (8.3%)-101 [1.2 (0.6 to 1.7)]p<0.00012916 (7.9%)2858 (8.1%)-58 [0.2 (-0.1 to 0.6)] p=0.2040Discharge destination, n(%)Home (own)13800 (62%)10484 (59.9%)-3316 [-2(-3.1 to -1.2)]p<0.000124961 (60.9%)23368 (61.1%)-1593 [-0.7 (-1.4 to -0.05)]p=0.0340Home (relative/carer)473 (2.1%)372 (2.1%)-101 [0 (-0.3 to 0.3)]p=0.9890974 (2.4%)852 (2.2%)-122 [-0.1(-0.4 to 0.06)]p=0.1653Mortuary*1501 (6.7%)1323 (7.6%)-178 [0.8(0.3 to 1.3)]p=0.00193086 (7.5%)2977 (7.8%)-109 [0.1 (-0.3 to 0.5)]p=0.5113No fixed abode75 (0.3%)47 (0.3%)-28 (-37.3%)107 (0.3%)87 (0.2%)-20 (-18.7%)Not Known87 (0.4%)39 (0.2%)-48 (-55.2%)101 (0.2%)95 (0.2%)-6 (-5.9%)Nursing Home1190 (5.3%)1063 (6.1%)-127 [0.7(0.3 to 1.2)]p=0.00202448 (6%)2231 (5.8%)-217 [-0.2(-0.6 to 0.1)]p=0.1620Other Acute hospital2425 (10.9%)1736 (9.9%)-689 [-0.1(-1.6 to -0.4)]p=0.00144346 (10.6%)3313 (8.7%)-1033 [-0.1(-0.5 to 0.2)]p=0.4115Other institution526 (2.4%)516 (2.9%)-10 [0.6 (0.3 to 0.9)]p=0.0003980 (2.4%)870 (2.3%)-110 [-0.1 (-0.3 to 0.1)]p=0.2817Rehabilitation2077 (9.3%)1871 (10.7%)-206 [1.3(0.7 to 1.9)]p<0.00013851 (9.4%)4274 (11.2%)423 [ 1.7(1.3 to 2.2)]p<0.0001Social care63 (0.3%)50 (0.3%)-13 [0 (-0.1 to 0.1)]p=0.9657121 (0.3%)103 (0.3%)-18 [-0.2(-0.1 to 0.5)]p=0.4939*These totals do not correspond as mortality includes deaths in the community and is censored at 30 daysResults and ConclusionThe first ‘lockdown’ had a larger associated reduction in total trauma volume (-21%) compared to the pre-COVID period than the second ‘lockdown’ (-6.7%). Trauma volume increased for those 65 and over (3%) and 85 and over (9.3%) during the second ‘lockdown’.There was a reduction in likelihood of survival (-1.71; 95% CI:-2.76 to -0.66) associated with the immediate introduction of the first ‘lockdown’. However, this was followed by a trend of improving survival (0.25; 95% CI: 0.14 to 0.35) and likelihood of survival returned to pre-pandemic levels by the end of the first ‘lockdown’ period.Future research is needed understand the initial reduction in likelihood of survival after major trauma observed with the implementation of the first ‘lockdown’ to prevent this occurring if measures re-introduced.
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Young, Richard A., Sarah Holder, Neelima Kale, Sandra K. Burge e Kaparaboyna A. Kumar. "Coding Family Medicine Residency Clinic Visits, 99213 or 99214? A Residency Research Network of Texas Study". Family Medicine 51, n. 6 (6 giugno 2019): 477–83. http://dx.doi.org/10.22454/fammed.2019.862757.
Abstract (sommario):
Background and Objectives: The purpose of this study was to characterize Current Procedural Terminology (CPT) coding patterns for professional services in family physician (FP) residency clinics. Methods: Trained assistants directly observed during every other FP-patient encounter in 10 clinics affiliated with eight residencies of the Residency Research Network of Texas. Three investigators later independently coded each visit for the highest code level reasonably allowed. The primary outcome was the number of clinic visits that were actually coded as a CPT 99203/213 that could have been coded at a higher level. Results: In 850 physician-patient encounters where the CPT code billed was identified, the investigators completely agreed on the allowable code 93% of the time. Overall, a 99203/13 or lower or preventive services code was billed in 651 visits (76.6%), more commonly in resident visits (515/570 [90.4%] vs 136/280 for faculty [48.6%], P<.001). There were 476/660 (72.1%) visits coded at a 99213 or less that could have been coded as a 99204/214 or higher. This was more common in resident visits 385/434 (88.7%), but there was undercoding in faculty patients as well 91/226 (40.3%). We found very few cases of overcoding—16 total. Conclusions and relevance: FPs coding patient encounters in residency clinics undercode for their work, which leads to decreased clinic revenue. This may be because the primary care exception is felt to be too onerous to bill for higher-paid codes, or a lack of knowledge of CMS coding rules among residents and faculty, or other reasons.
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Rome, Sophie, Virginie Lecomte, Emmanuelle Meugnier, Jennifer Rieusset, Cyrille Debard, Vanessa Euthine, Hubert Vidal e Etienne Lefai. "Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle". Physiological Genomics 34, n. 3 (agosto 2008): 327–37. http://dx.doi.org/10.1152/physiolgenomics.90211.2008.
Abstract (sommario):
In this study we have identified the target genes of sterol regulatory element binding protein (SREBP)-1a and SREBP-1c in primary cultures of human skeletal muscle cells, using adenoviral vectors expressing the mature nuclear form of human SREBP-1a or SREBP-1c combined with oligonucleotide microarrays. Overexpression of SREBP-1a led to significant changes in the expression of 1,315 genes (655 upregulated and 660 downregulated), whereas overexpression of SREBP-1c modified the mRNA level of 514 genes (310 upregulated and 204 downregulated). Gene ontology analysis indicated that in human muscle cells SREBP-1a and -1c are involved in the regulation of a large number of genes that are at the crossroads of different functional pathways, several of which are not directly connected with cholesterol and lipid metabolism. Six hundred fifty-two of all genes identified to be differentially regulated on SREBP overexpression had a sterol regulatory element (SRE) motif in their promoter sequences. Among these, 429 were specifically regulated by SREBP-1a, 69 by SREBP-1c, and 154 by both 1a and 1c. Because both isoforms recognize the same binding motif, we determined whether some of these functional differences could depend on the environment of the SRE motifs in the promoters. Results from promoter analysis showed that different combinations of transcription factor binding sites around the SRE binding motifs may determine regulatory networks of transcription that could explain the superposition of lipid and cholesterol metabolism with various other pathways involved in adaptive responses to stress like hypoxia and heat shock, or involvement in the immune response.
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Haferlach, Torsten, Manja Meggendorfer, Susanne Schnittger, Annette Fasan, Wolfgang Kern e Claudia Haferlach. "Clinical Impact of Minimal Residual Disease (MRD) Monitoring in AML with PM-Rara, CBFB-MYH11, and RUNX1-RUNX1T1: A Study on 600 Patients". Blood 126, n. 23 (3 dicembre 2015): 228. http://dx.doi.org/10.1182/blood.v126.23.228.228.
Abstract (sommario):
Abstract Introduction: The cure rate in AML is dependent on patient´s (pts) age and performance, cytogenetics, early blast clearance and sustainable first complete remission. Investigation of minimal residual disease (MRD) is possible by multiparameter flow cytometry and molecular techniques. Recent findings have further depicted a broad spectrum of molecular markers in AML in 99% of pts (TCGA, NEJM, 2013). This broadens the portfolio of targets for MRD assessment and will hopefully help to better individualize treatment strategies. We here focused - as a paradigm - on the three hallmarks for molecular MRD studies in AML. Aims: To better define the clinical impact and to suggest strategies for MRD monitoring in AML with PML-RARA, CBFB-MYH11, and RUNX1-RUNX1T1. Patients and Methods: Between 2005 und 2015 we at diagnosis investigated 321 PML-RARA, 134 CBFB-MYH11, and 145 RUNX1-RUNX1T1 AML pts. Individual follow-up time points during their course of disease were studied in 2657, 1047, and 890 samples, respectively. Thus, the combined number of investigated samples is 4,594. Molecular techniques applied comprised quantitative real-time PCR and nested PCR. Median age in PML-RARA was 52 years (yrs) (2-86 yrs), in CBFB-MYH11 53 yrs (21-81 yrs), and in RUNX1-RUNX1T1 52 yrs (10-83 yrs). Median time between 2 investigations was 3.0 months (mo) in PML-RARA, 2.1 mo in CBFB-MYH11, and 2.8 mo in RUNX1-RUNX1T1 pts (range for all 0.1-40.4 mo), respectively. All pts were treated with standard protocols according to genotype and age. Allogeneic bone marrow or stem cell transplantation was performed in 85 pts (14%). Results: 294/321 pts (92%) with PML-RARA achieved complete molecular remission (CMR) after a median of 2.9 mo (range: 0.8-9.7 mo). In contrast, in CBFB-MYH11 CMR was reached in 89/134 pts (66%) after a median of 7.4 mo (range: 1.6-16.8 mo), and in RUNX1-RUNX1T1 CMR was reached in 75/145 pts (51%) after a median of 4.7 mo (range: 1.0-11.5 mo). Of note, some of the CBFB-MYH11 pts never reached CMR, always showing low level signals. 95% (278/294) of PML-RARA pts that achieved CMR stayed in first CMR and did not relapse within a median follow-up of 32.6 mo (range: 1.2-134.5 mo). 5% (16/294) relapsed at a median interval after CMR of 8.1 mo. However, a second CMR was reached in 12/16 pts after relapse. Five of these 12 pts suffered from second relapses, whereof 4 pts achieved a third CMR. Third relapses occurred in 2/4 pts. 69/89 (78%) of pts with CBFB-MYH11 stayed in first CMR and never relapsed during a median follow-up of 10.4 mo (range: 1.6-47.1 mo). 20/89 relapsed after 4.0 mo of CMR, whereof 11 achieved second CMR. 3/11 relapsed again. 63/75 (84%) of pts with RUNX1-RUNX1T1 stayed in first CMR and never relapsed during a median follow-up of 10.1 mo (range: 1.0-65.8 mo). However, 12/75 relapsed after a median time of CMR of 5.3 mo. 4/12 achieved another CMR. In 85 patients (10 PML-RARA, 42 CBFB-MYH11, and 33 RUNX1-RUNX1T1) allogeneic bone marrow or stem cell transplantation (Tx) was performed, and 72/85 (85%) were rescued by Tx. However, two patients each with PML-RARA and RUNX1-RUNX1T1 relapsed, respectively, and 9 in CBFB-MYH11 positive AML after Tx. Patients did not experience first relapse later than 50.3 mo in CMR in PML-RARA, later than 30.7 mo in CBFB-MYH11, and later than 35.7 mo in RUNX1-RUNX1T1. Additionally, keeping periods between two MRD samplings at a maximum of 3 mo allowed the detection of nearly all cases of first relapse due to the molecular hint. Addressing the sensitivity levels of the assays applied to bone marrow (BM) versus peripheral blood (pB) samples showed a 1.4 fold higher sensitivity for BM samples (median copies of reference gene, 13,204 vs 9,240). Due to the comparable sensitivities pB can be investigated until a first hint of relapse, followed by BM sampling for confirmation. Conclusions: 1) MRD by molecular techniques reliably defines pts risks in AML with PML-RARA, CBFB-MYH11, and RUNX1-RUNX1T1, respectively. 2) Clinical decisions are reliable within screening intervals of 3 mo using pB. 3) Relapses in first CMR are not detected later than 50.3 mo in PML-RARA, 30.7 mo in CBFB-MYH11, and 35.7 mo in RUNX1-RUNX1T1 AML, respectively. 4) Pts after relapse can be rescued by transplantation in the majority of cases. 5) As the availability of other molecular markers in AML has dramatically increased, more individualized treatment strategies based on specific MRD monitoring are achievable in nearly every patient in the near future. Disclosures Haferlach: MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Meggendorfer:MLL Munich Leukemia Laboratory: Employment. Schnittger:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Fasan:MLL Munich Leukemia Laboratory: Employment. Kern:MLL Munich Leukemia Laboratory: Employment, Equity Ownership. Haferlach:MLL Munich Leukemia Laboratory: Employment, Equity Ownership.
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Graham, George G., William C. MacLean, Kenneth H. Brown, Enrique Morales, Jorge Lembcke e Arturo Gastañaduy. "Protein Requirements of Infants and Children: Growth During Recovery From Malnutrition". Pediatrics 97, n. 4 (1 aprile 1996): 499–505. http://dx.doi.org/10.1542/peds.97.4.499.
Abstract (sommario):
Objective. To evaluate the adequacy of protein intakes now recommended as safe for infants and toddlers. Methods. Subjects were recovering malnourished infants, age 5.3 to 17.9 months, length age (LA) 2.5 to 6.4 months, weight age (WA) 1.5 to 5.2 months, weight/length (W/L) 78% to 100% of National Center for Health Statistics data; and toddlers age 11.4 to 31.6 months, LA 6.1 to 17.9 months, WA 3.9 to 12.0 months, W/L 79% to 99%. Infants were assigned at random to formulas with 5.5%, 6.7%, or 8.0% energy as 60:40 whey:casein protein. The 5.5% was based on FAO-WHO-UNU safe protein and average energy for ages 2.5 to 6.0 months. Toddlers received 4.7% (recommended for 6 to 18 months), 6.4%, or 8.0%. Identical concentrations (weight/kcal) of other nutrients were maintained; intakes were adjusted weekly to reach, in 90 days, the 50th percentile of weight for a LA 3 months greater than the initial one. Results. Infants consumed 125 ± 11 (SD), 116 ± 10, and 126 ± 14 kcal and 1.7 ± 0.1, 1.9 ± 0.2, and 2.5 ± 0.3 g protein Kg-1· d-1; gained 2.4 ± 0.7, 2.9 ± 0.7, and 2.6 ± 0.5 months in LA, and reached a W/L of 105 ± 5, 103 ± 6, and 105 ± 5% of reference. Sum of four fat-folds (Σ FF) grew 13.1 ± 6.9, 10.4 ± 4.8, and 11.7 ± 5.3 mm to 32.5 ± 5.2, 31.7 ± 4.7, and 30.5 ± 5.5 mm; arm muscle areas (AMA) 57%, 51%, 70% to 1004 ± 109, 1017 ± 110, and 1004 ± 116 mm2, still low; arm fat areas (AFA) 93%, 66%, and 93% to higher-than-normal 598 ± 105, 610 ± 101, and 541 ± 116 mm2. Regression of intake on weight gain estimated energy for maintenance + activity to be 81.0 ± 7.5 (SEM) kcal · kg-1· d-1, and cost of gain (storage + metabolic cost) as 7.6 ± 1.7 kcal/g, with no significant effect of % protein. Toddlers consumed 107 ± 9, 103 ± 12, and 105 ± 10 kcal and 1.3 ±0.1, 1.6 ± 0.2, and 2.1 ± 0.2 g protein kg-1 · d-1; gained 3.3 ± 0.7, 2.9 ± 0.6, and 3.3 ± 0.7 months in LA; to a W/L of 102 ± 1, 102 ± 3, and 101 ± 4%. Σ FF grew 9.2 ± 4.0, 7.4 ± 4.3, and 6.0 ± 3.8 to 28.9 ± 5.2, 30.5 ± 3.7, and 27.0 ± 2.7 mm; AMA 31%, 33%, and 34% to 1121 ± 115, 1124 ± 110, and 1117 ± 120 mm2; AFA 53%, 44%, and 45% to higher-than-normal 578 ± 106, 636 ± 99, and 569 ± 68 mm2. Cost of maintenance + activity was 70.8 ± 3.8 (SEM) kcal · kg-1 · d-1, that of weight gain 9.7 ± 1.35 kcal/g, with no effect of % protein. Conclusions. Within age groups, there were no significant protein-related differences in growth. In both infants and toddlers, high-energy intakes resulted in mild obesity, with lean body mass still deficient. Protein intakes two SD below the means in the lowest protein/energy cells, 1.5 g · kg-1 · d-1 for infants and 1.1 g · Kg-1 · d-1 for toddlers, should still be safe for nearly all children of comparable biological ages.
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Savchenko, D., Ekaterina N. Kalabukhova, A. Sitnikov, A. V. Vasin, S. Starik, O. Gontar, G. Rudko, A. N. Nazarov, V. S. Lysenko e V. Tertykh. "Magnetic Resonance and Optical Study of Carbonized Silica Obtained by Pyrolysis of Surface Compounds". Advanced Materials Research 854 (novembre 2013): 99–104. http://dx.doi.org/10.4028/www.scientific.net/amr.854.99.
Abstract (sommario):
The carbonized silica (SiO2:C) nanopowders were prepared by chemical modification of fumed silica (aerosil) by phenyltrimethoxysilane followed by thermal annealing at temperature in range of 500-800 °C in nitrogen flow. Their magnetic properties were investigated by electron paramagnetic resonance (EPR) in the temperature range from 4.2 K to 292 K. The initial and annealed SiO2:C samples revealed carbon (C) related defects. The carbon related radicals (CRR) in annealed SiO2:C nanopowders withg-factors 2.0042, 2.0039 were attributed to the oxygen (O)-centered CRR and C-centered CRR with a nearby O heteroatom, respectively. The EPR data were compared with infrared (IR) and photoluminescence (PL) data. It was found that the position of the PL band depends on the type of CRR formed after sample annealing. The PL with maximum intensity at 440 nm was found for the sample annealed at 500°C in which O-centered CRR was observed while in the sample annealed at 600°C in which C-centered CRR with a nearby O heteroatom was observed and graphite-like amorphous C clusters were appeared the peak of the PL band was shifted to the 510-520 nm.
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Engoren, Milo, e Daniel Barbee. "Comparison of Cardiac Output Determined by Bioimpedance, Thermodilution, and the Fick Method". American Journal of Critical Care 14, n. 1 (1 gennaio 2005): 40–45. http://dx.doi.org/10.4037/ajcc2005.14.1.40.
Abstract (sommario):
• Background Cardiac output can be determined by using a variety of methods.• Objectives To determine the precision and bias between 3 methods for determining cardiac output: bioimpedance, thermodilution, and the Fick method.• Methods Cardiac output was determined by using bioimpedance via neck and thorax patches and thermodilution via pulmonary artery catheter in 46 patients in the intensive care unit. A subset of 15 patients also had cardiac output determined by using the Fick method.• Results Mean (SD) cardiac output in all patients was 6.3 (2.2) L/min by thermodilution and 5.6 (2.0) L/min by bioimpedance. In the 15 patients in whom all 3 methods were used, mean cardiac output was 6.0 (1.7) L/min by thermodilution, 5.3 (1.7) L/min by bioimpedance, and 8.6 (4.5) L/min by the Fick method. Bias and precision (mean difference ± 2 SDs) were 0.7 ± 2.9 L/min between thermodilution and bioimpedance, 1.7 ± 3.8 L/min between the Fick method and thermodilution, and 2.4 ± 4.7 L/min between the Fick method and bioimpedance.• Conclusion Bioimpedance, thermodilution, and Fick determinations of cardiac outputs are not interchangeable in a heterogenous population of critically ill patients.
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Bui, Anh-Hoa, e Hoang Le. "STRENGTH AND MICROSTRUCTURE OF COLD-ROLLED IF STEEL". Acta Metallurgica Slovaca 22, n. 1 (29 marzo 2016): 35. http://dx.doi.org/10.12776/ams.v22i1.690.
Abstract (sommario):
<p>With the emerge of vacuum technology, it is possible to produce ultra low carbon (ULC) steels with carbon content of less than 0.005 %mass which is called interstitial free (IF) steels. In this study, strength and microstructure of IF steel after cold-rolling have been determined. The initial steel plates were cold-rolled using two different cold reductions (CR) as 80 and 90% in total, thereafter the steel sheets were cut into specimens for tensile test and optical microscopy. Ultimate tensile strength (UTS) of the cold-rolled steel was high (650¸807 MPa), but the elongation (EL) was low (3.5¸5.3%). Meanwhile, UTS of the annealed steels was decreased to 290 MPa when soaking temperature was 800<sup>o</sup>C because of stress relief and recrystallization. It was concluded that higher CR (more severe deformation) increased the strength but decreased the ductility of the IF steels. In consistence with micrograph of the steels, X-ray diffraction (XRD) results showed that microstructure of the cold-rolled and annealed IF steels was only ferrite. Textures, one of the most important factors affecting the recrystallization, were found in cold-rolled steels.</p>
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Pasha, A. B. M. Kamal, Syed Omayer Mustafa, S. M. Mahmudur Rahman, Muhammad Abdullah, Md Azharul Haque Chowdhury e Mahfuza Parveen. "Analysis of Water Quality of Hatirjheel Lake, Dhaka, Bangladesh". Nature Environment and Pollution Technology 22, n. 1 (2 marzo 2023): 245–52. http://dx.doi.org/10.46488/nept.2023.v22i01.023.
Abstract (sommario):
The study assessed the status of water quality parameters for an urban water body (Hatirjheel Lake) in Dhaka, the Capital city of Bangladesh. Nine different water samples were collected from nine points of the lake during the dry season in January 2021. Water quality parameters such as pH, electrical conductivity (EC), total dissolved solids (TDS), total suspended solids (TSS), total alkalinity, total acidity, total hardness, Ca2+ hardness, free CO2, and dissolved oxygen (DO) were determined for the samples. The status of the parameters is pH (6.51-7.05), EC (510-600 μS.cm-1), TDS (450-590 ppm), TSS (0.0-0.034 mg.L-1), total alkalinity (80-392 mg.L-1), total acidity (224-500 mg.L-1), total hardness (348-452 mg.L-1), Ca2+ hardness (74-162 mg.L-1), free CO2 (730-1170 mg.L-1), DO (2.7-5.5 mg.L-1). However, the DO value at some points of the lake is too less (2.7 mg.L-1 and 3.7 mg.L-1) than the standard value (> 5-6 mg.L-1) of ECR, DoE, which might not be healthy for any water body and aquatic ecosystem. Other water quality parameters are within the permissible limit of WHO and ECR, DoE.
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Kalra, Paul R., Jonathan R. Clague, Andrew J. Coats, Stefan D. Anker, Philip A. Poole-Wilson e Allan D. Struthers. "C-type natriuretic peptide production by the human kidney is blunted in chronic heart failure". Clinical Science 118, n. 1 (2 ottobre 2009): 71–77. http://dx.doi.org/10.1042/cs20090092.
Abstract (sommario):
CNP (C-type natriuretic peptide) is a vasodilatory peptide produced by vascular endothelium and the human heart with a short half-life. CNP has been identified within the human kidney; however, few results are available on whether the human kidney is a systemic source of CNP. The aim of the present study was to establish whether CNP is secreted by the human kidney and if synthesis is blunted in CHF (chronic heart failure). A total of 20 male subjects (age, 57±2 years; mean±S.E.M.) undergoing CHF assessment (n=13) or investigation of paroxysmal supraventricular arrhythmia (normal left ventricular function in sinus rhythm during procedure) (n=7) were recruited. Renal CNP production was determined from concomitant plasma concentrations in the aorta and renal vein. When considering all subjects, a significant step-up in plasma CNP was found from the aorta to renal vein (3.0±0.3 compared with 8.3±2.4 pg/ml respectively; P=0.0045). The mean increase in CNP was 5.3±2.4 pg/ml (range, −0.9 to +45.3 pg/ml). In patients with CHF, the aortic concentration was 3.3±0.4 pg/ml compared with a renal vein concentration of 4.3±0.6 pg/ml (P=0.11). In those with normal left ventricular function, the respective values were 2.5±0.5 and 15.7±6.0 pg/ml (P=0.01). In conclusion, CNP is synthesized and secreted into the circulation by the normal human kidney, where it may have paracrine actions. Net renal secretion of CNP appears to be blunted in patients with CHF.
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Malhotra, K., O. Chan, S. Cullen, M. Welck, A. J. Goldberg, N. Cullen e D. Singh. "Prevalence of isolated gastrocnemius tightness in patients with foot and ankle pathology". Bone & Joint Journal 100-B, n. 7 (luglio 2018): 945–52. http://dx.doi.org/10.1302/0301-620x.100b7.bjj-2017-1465.r1.
Abstract (sommario):
Aims Gastrocnemius tightness predisposes to musculoskeletal pathology and may require surgical treatment. However, it is not clear what proportion of patients with foot and ankle pathology have clinically significant gastrocnemius tightness. The aim of this study was to compare the prevalence and degree of gastrocnemius tightness in a control group of patients with a group of patients with foot and ankle pathology. Patients and Methods This prospective, case-matched, observational study compared gastrocnemius tightness, as assessed by the lunge test, in a control group and a group with foot and ankle pathology. Gastrocnemius tightness was calculated as the difference in dorsiflexion of the ankle with the knee extended and flexed. Results A total of 291 controls were paired with 97 patients with foot and ankle pathology (FAP). The mean gastrocnemius tightness was 6.0° (sd 3.5) in controls and 8.0° (sd 5.7) in the FAP group (p < 0.001). Subgroup analysis showed a mean gastrocnemius tightness of 10.3° (sd 6.0) in patients with forefoot pathology versus 6.9° (sd 5.3) in patients with other pathology (p = 0.008). A total of 12 patients (37.5%) with forefoot pathology had gastrocnemius tightness of > two standard deviations of the control group (> 13°). Conclusion Gastrocnemius tightness of > 13° may be considered abnormal. Most patients with foot and ankle pathology do not have abnormal degrees of gastrocnemius tightness compared with controls, but it is present in over a third of patients with forefoot pathology. Cite this article: Bone Joint J 2018;100-B:945–52.