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Letteratura scientifica selezionata sul tema "62F99"

Autore: Grafiati

Pubblicato: 5 ottobre 2024

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Articoli di riviste sul tema "62F99"

Chattopadhyay, Gaurangadeb. "Detailed Statistical Inference – From Multiple Decisions to Confidence Sets – A NonBayesian Approach". Calcutta Statistical Association Bulletin 50, n. 1-2 (marzo 2000): 17–32. http://dx.doi.org/10.1177/0008068320000102.

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A new approach to detailed statistical inference for the two-decision and multiple decision problem was developed by Chatterjee and Chattopadhyay (1992, 1993). The procedure developed for the multipledecision case is used here to find a solution to, what may be called, the problem of estimation by a ‘confidence set’ when the parameter space is finite. The confidence set problem in which we are required to state a datadependent measure of ‘confidence’ which can be interpreted in terms of betting odds that are ‘optimal’ under repeated experimentation, is considered. A truncated form of utility function is introduced. The case of the truncated form of logarithmic utility function is considered in detail. AMS {2000} Subject Classification: 62A01, 62F99.

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Mansoori, Naveed. "Fearing the Night". Comparative Islamic Studies 13, n. 1-2 (23 ottobre 2019): 170–78. http://dx.doi.org/10.1558/cis.39131.

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Transnationalism in Iranian Political Thought: The Life and Times of Ahmad Fardid, by Ali Mirsepassi. Cambridge University Press, 2017. 408pp., Hb. £62.99, ISBN-13: 9781107187290; Pb. £19.99, ISBN-13: 9781316636473.

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Mukhopadhyay, N., e S. Chattopadhyay. "Simultaneous Estimation of Proportions in a Finite Population". Calcutta Statistical Association Bulletin 43, n. 1-2 (marzo 1993): 65–74. http://dx.doi.org/10.1177/0008068319930106.

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Sequential and multistage sampling strategies via simple random sampling without replacement, are proposed for simultaneously estimating several proportions in a finite population. Various asymptotic first-order properties are addressed, while some limited moderate sample performance have also been included. AMS (1980) Subject Classification: Primary 62L99; Secondary 62L12

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Mandal, N. K., e K. R. Shah. "Designs Robust Against Aberrations". Calcutta Statistical Association Bulletin 43, n. 1-2 (marzo 1993): 95–108. http://dx.doi.org/10.1177/0008068319930109.

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In this paper, we obtain sufficient conditions for a design to be robust against aberrations in the sense of Box and Draper. Block designs, row-column designs and fractional designs are considered here. An alternative formulation of robustness is also presented. AMS Subject Classification: Primary 62K99; Secondary 62K05.

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Dhillon, Sharanjit Singh. "Book review: C. Veeramani and R. Nagraj (eds), International Trade and Industrial Development in India: Emerging Trends, Patterns and Issues". Sociological Bulletin 67, n. 2 (4 luglio 2018): 241–43. http://dx.doi.org/10.1177/0038022918775449.

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C. Veeramani and R. Nagraj (eds), International Trade and Industrial Development in India: Emerging Trends, Patterns and Issues. Hyderabad: Orient Blackswan, 2016, xviii + 399 pp., (hardback). ISBN 978-81-250-6299-8

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Stewart-Brown, Benjamin B., E. Dale Wood, Jim Noe, H. Roger Boerma e Zenglu Li. "Registration of G13-6299 Soybean Germplasm Line with Diverse Pedigree". Journal of Plant Registrations 12, n. 1 (gennaio 2018): 132–37. http://dx.doi.org/10.3198/jpr2017.07.0041crg.

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Perez, Samantha M., Brian P. Murphy, Danielle B. Heckert, Sarah Hall, Abby L. Colvin, Molly F. Owens, Ben R. Verfurth et al. "Abstract 6299: ZB131 antibody-drug conjugates induce potent antitumor activity". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 6299. http://dx.doi.org/10.1158/1538-7445.am2023-6299.

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Abstract Antibody-drug conjugates (ADCs) have become increasingly adopted clinically, with 13 drugs FDA-approved and over 100 under clinical development. Despite this momentum and major advances in payload and linker technology, ADCs are limited by off-cancer target-mediated toxicities incurred by currently available targets. In contrast to genomic and proteomic strategies, our unique drug discovery approach accounts for a disease’s native context. This led to the identification of cancer-specific plectin (CSP) as not only overexpressed in malignant tissue compared to healthy, but exclusively present on the surface of cancer cells and absent in normal or pre-malignant tissue. A Phase 0 imaging trial (Biodistribution of Novel Imaging for Resectable Pancreatic Cancer - NCT01962909) evaluating a radiolabeled CSP-targeted peptide has revealed that CSP is bioavailable and abundant, with over a million CSP molecules per cancer cell in pancreatic cancer. Previously, we generated ZB131, a humanized monoclonal antibody that targets CSP. ZB131 demonstrated potent monotherapy efficacy in pancreatic, ovarian, and bile duct preclinical cancer models, indications that have high CSP expression and are being evaluated in a first-in-human Phase 1/2 clinical trial (NCT05074472). Here, we show that CSP is an ideal target for an ADC: it is abundantly and selectively expressed in many indications, bioavailable, and its inhibition is predicted to synergize with FDA-approved payloads. ZB131 binds specifically to CSP, rapidly internalizes, displays linear pharmacokinetics in pre-clinical models, and demonstrates a strong safety profile. We describe the development of two ZB131 ADCs, ZB131-MMAE (monomethyl auristatin E) and ZB131-DXd (Deruxtecan), with drug-to-antibody ratios of 3 – 4 and 7 – 8, respectively. After binding, both ADCs are rapidly and specifically internalized by CSP-positive cells resulting in drug payload release and enhancing cancer cell death compared to ZB131 alone. Moreover, we characterize cytotoxic activity in high and low CSP cell lines to evaluate ADC activity in relation to CSP abundance. In preclinical xenograft models, ZB131-ADC enhanced tumor regression compared to controls at clinically relevant doses. Furthermore, anti-huIgG staining revealed selective target engagement by ZB131-ADC. Taken together, these data show that ZB131-ADCs demonstrate potent antitumor activity and support their evaluation in a Phase 1 clinical trial. Citation Format: Samantha M. Perez, Brian P. Murphy, Danielle B. Heckert, Sarah Hall, Abby L. Colvin, Molly F. Owens, Ben R. Verfurth, Julien Dimastromatteo, Jiang He, Reid B. Adams, Yelena Kovtun, Lindsey T. Brinton, Kimberly A. Kelly. ZB131 antibody-drug conjugates induce potent antitumor activity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6299.

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Mahomoodally, Mohamad Fawzi, Sharmeen Jugreet, Kouadio Ibrahime Sinan, Gokhan Zengin, Gunes Ak, Ramazan Ceylan, József Jekő et al. "Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant". Antibiotics 10, n. 2 (23 febbraio 2021): 223. http://dx.doi.org/10.3390/antibiotics10020223.

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To avail the possible pharmacological actions of Brideliaferruginea Benth., the present investigation was designed to quantitatively analyze the total flavonoid and phenolic contents and assess the various antioxidant and enzyme inhibition properties of leaf and stem bark extracts (ethyl acetate, water and methanolic) of B. ferruginea. Anti-proliferative effect was also investigated against human colon cancer cells (HCT116) as well as the antimicrobial potential against multiple bacterial and fungal (yeasts and dermatophytes) strains. The methanolic and water extracts of the stem bark demonstrated the highest phenolic content (193.58 ± 0.98 and 187.84 ± 1.88 mg/g, respectively), while the leaf extracts showed comparatively higher flavonoid contents (24.37–42.31 mg/g). Overall, the methanolic extracts were found to possess the most significant antioxidant potency. Compared to the other extracts, methanolic extracts of the B. ferruginea were revealed to be most potent inhibitors of acetyl- and butyryl-cholinesterases, tyrosinase α-amylase, except α-glucosidase. Only the ethyl acetate extracts were found to inhibit glucosidase. Additionally, the stem bark methanolic extract also showed potent inhibitory activity against E. coli and gram-positive bacteria (MIC (minimum inhibitory concentration): 2.48–62.99 µg/mL), as well as all the tested fungi (MIC: 4.96–62.99 µg/mL). In conclusion, B. ferruginea can be regarded as a promising source of bioactive compounds displaying multifunctional pharmacological activities and thus is a potential candidate for further investigations in the endeavor to develop botanical formulations for pharmaceutical and cosmeceutical industries.

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Flood, L. "CHRONIC OTITIS MEDIA: PATHOGENESIS ORIENTED THERAPEUTIC MANAGEMENTB Ars (ed) Kugler Publications, 2008 ISBN 10: 90 6299 216 1/13: 978 6299 216 4 Price €110, US$165". Journal of Laryngology & Otology 123, n. 2 (2 dicembre 2008): 257. http://dx.doi.org/10.1017/s002221510800412x.

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Ogata, Hideaki, Elena Decaneto, Moran Grossman, Martina Havenith, Irit Sagi, Wolfgang Lubitz e Markus Knipp. "Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase". Acta Crystallographica Section F Structural Biology Communications 70, n. 2 (22 gennaio 2014): 232–35. http://dx.doi.org/10.1107/s2053230x13034857.

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Membrane type 1 matrix metalloproteinase (MT1-MMP) belongs to the large family of zinc-dependent endopeptidases termed MMPs that are located in the extracellular matrix. MT1-MMP was crystallized at 277 K using the vapour-diffusion method with PEG as a precipitating agent. Data sets for MT1-MMP were collected to 2.24 Å resolution at 100 K. The crystals belonged to space groupP43212, with unit-cell parametersa= 62.99,c= 122.60 Å. The crystal contained one molecule per asymmetric unit, with a Matthews coefficient (VM) of 2.90 Å3 Da−1; the solvent content is estimated to be 57.6%.

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Tesi sul tema "62F99"

Pic, Romain. "Statistical postprocessing of ensemble forecasts : theory, application in weather forecasting and verification". Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCD018.

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Cette thèse porte sur l'utilisation de méthodes de post-traitement statistiques dans le but d'améliorer les prévisions d'ensemble. Les prévisions d'ensemble sont des prévisions composées de différents membres dont la diversité tente de capturer l'incertitude liée à la prédiction. Les prévisions d'ensemble souffrent de biais et de sous-dispersion et un post-traitement est donc nécessaire afin d'améliorer leur performance. D'un point de vue théorique, cette thèse apporte des résultats sur le taux de convergence en régression distributionnelle en termes de continuous ranked probability score. De nombreuses méthodes de post-traitement statistiques établies tombent dans le cadre théorique de ce résultat. Par ailleurs, dans le cadre de la collaboration avec Météo-France, une méthode de post-traitement statistique basée sur un réseau de neurones U-Net a été développée afin de remédier aux limitations des méthodes utilisées opérationnellement lors de l'utilisation de données sous forme de grille. Cette thèse propose également la construction de scoring rules propres basées sur l'agrégation et la transformation afin de faciliter la vérification de prévisions probabilistes dans le cas multivarié.En parallèle de la thématique principale de cette thèse, des travaux portant sur la convergence universelle en régression distributionnelle et sur l'utilisation de méthodes de régression distributionnelle pour prédire le risque de récurrence de cancer du sein ont été conduits
This thesis focuses on the use of statistical postprocessing methods to improve ensemble forecasts. Ensemble forecasts are composed of different members whose diversity attempts to capture forecast uncertainties. Ensemble forecasts suffer from bias and underdispersion, and postprocessing is therefore necessary to improve their performance. From a theoretical point of view, this thesis provides rates of convergence for distributional regression in terms of continuous ranked probability score. Numerous well-established statistical post-processing methods fall within the theoretical framework of this result. Furthermore, in collaboration with Météo-France, a statistical postprocessing method based on a U-Net neural network has been developed to overcome the limitations of the methods used operationally when using gridded data. This thesis also proposes the construction of proper scoring rules based on aggregation and transformation to facilitate the verification of probabilistic forecasts in multivariate settings.In parallel with the main theme of this thesis, work has been carried out on universal convergence in distributional regression and on the use of distributional regression methods to predict breast cancer recurrence risk

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Schreuder, Nicolas. "A study of some trade-offs in statistical learning : online learning, generative models and fairness". Electronic Thesis or Diss., Institut polytechnique de Paris, 2021. http://www.theses.fr/2021IPPAG004.

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Les algorithmes d'apprentissage automatique sont reconnus pour leurs performances impressionnantes sur de nombreuses tâches que l'on croyait dédiées à l'esprit humain, de la reconnaissance des chiffres manuscrits (LeCun et al. 1990) au pronostic du cancer (Kourou et al. 2015). Néanmoins, l'apprentissage automatique devenant de plus en plus omniprésent dans notre quotidien, il existe un besoin croissant de comprendre précisément leurs comportements et leurs limites.La théorie de l'apprentissage statistique est la branche de l'apprentissage automatique qui vise à fournir un formalisme de modélisation solide pour les problèmes d'inférence ainsi qu'une meilleure compréhension des propriétés statistiques des algorithmes d'apprentissage.Il est important de noter que la théorie de l'apprentissage statistique permet (i) de mieux comprendre les cas dans lesquels un algorithme fonctionne bien (ii) de quantifier les compromis inhérents à l'apprentissage pour des choix algorithmiques mieux informés (iii) de fournir des informations pour développer de nouveaux algorithmes qui finira par surpasser ceux existants ou s'attaquer à de nouvelles tâches. S'appuyant sur le cadre d'apprentissage statistique, cette thèse présente des contributions liées à trois problèmes d'apprentissage différents : l'apprentissage en ligne, l'apprentissage des modèles génératifs et, enfin, l'apprentissage équitable.Dans la configuration d'apprentissage en ligne - dans laquelle la taille de l'échantillon n'est pas connue à l'avance - nous fournissons des bornes de déviations (ou intervalles de confiance) uniformes dans la taille de l'échantillon dont la largeur a le taux donné dans la loi du logarithme itéré pour une classe générale de M-estimateurs convexes -- comprenant la moyenne, la médiane, les quantiles, les M-estimateurs de Huber.En ce qui concerne les modèles génératifs, nous proposons un cadre pratique pour étudier les modèles génératifs adversariaux (Goodfellow et al. 2014) d'un point de vue statistique afin d'évaluer l'impact d'une (éventuelle) faible dimensionnalité intrinsèque des données sur l'erreur du modèle génératif. Dans notre cadre, nous établissons des limites de risque non asymptotiques pour le minimiseur du risque empirique (MRE).Enfin, notre travail sur l'apprentissage équitable consiste en une large étude de la contrainte de parité démographique (DP en anglais), une contrainte populaire dans la littérature sur l'apprentissage équitable. La parité démographique contraint essentiellement les prédicteurs à traiter les groupes définis par un attribut sensible (par exemple, le sexe ou l'origine ethnique) pour qu'ils soient « traités de la même manière ». En particulier, nous proposons un cadre statistique minimax pour quantifier précisément le coût en risque d'introduire cette contrainte dans le cadre de la régression
Machine learning algorithms are celebrated for their impressive performance on many tasksthat we thought were dedicated to human minds, from handwritten digits recognition (LeCunet al. 1990) to cancer prognosis (Kourou et al. 2015). Nevertheless, as machine learning becomes more and more ubiquitous in our daily lives, there is a growing need for precisely understanding their behaviours and their limits.Statistical learning theory is the branch of machine learning which aims at providing a powerful modelling formalism for inference problems as well as a better understanding of the statistical properties of learning algorithms.Importantly, statistical learning theory allows one to (i) get a better understanding of the cases in which an algorithm performs well (ii) quantify trade-offs inherent to learning for better-informed algorithmic choices (iii) provide insights to develop new algorithms which will eventually outperform existing ones or tackle new tasks. Relying on the statistical learning framework, this thesis presents contributions related to three different learning problems: online learning, learning generative models and, finally, fair learning.In the online learning setup -- in which the sample size is not known in advance -- we provide general anytime deviation bounds (or confidence intervals) whose width has the rate given in the Law of Iterated Logarithm for a general class of convex M-estimators -- comprising the mean, the median, quantiles, Huber’s M-estimators.Regarding generative models, we propose a convenient framework for studying adversarial generative models (Goodfellow et al. 2014) from a statistical perspective to assess the impact of (eventual) low intrinsic dimensionality of the data on the error of the generative model. In our framework, we establish non-asymptotic risk bounds for the Empirical Risk Minimizer (ERM).Finally, our work on fair learning consists in a broad study of the Demographic Parity (DP) constraint, a popular constraint in the fair learning literature. DP essentially constrains predictors to treat groups defined by a sensitive attribute (e.g., gender or ethnicity) to be “treated the same”. In particular, we propose a statistical minimax framework to precisely quantify the cost in risk of introducing this constraint in the regression setting

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Uqba, Khaled Ali. "The water resources of the United Arab Emirates : a comprehensive empirical appraisal of their status and management". Thesis, Durham University, 1991. http://etheses.dur.ac.uk/6299/.

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The expansion in the cultivated area since the mid-1970s, and the eventual high demand for water, have taxed the groundwater resources of the Emirates to the limit. The annual groundwater abstraction by agriculture, based on average discharge measurements for the present study, is put at 2556 MCM/a. while the overall groundwater volume abstracted by all sectors is 3359 MCM/a; the total output from all the desalination plants at 300 MCM/a, and that from the wastewater recycling plants at 80 MCM/a. With the population for 1989 standing at .1.8 million, the per capita consumption is 2116 m( 3)/a, which is close to that for the United States of America (2300 m( 3)/a ).The water resource problem is common to all the Gulf Cooperation Council states. In the Emirates, as in all the neighbouring countries, the problem is embodied in the paradox of expansion in extensive agriculture despite the depleting groundwater resources. There is also the absence of a water policy, a plan or coherent water resource management. For the last aspect, there is a lack of indigenous expertise with the necessary knowledge to monitor water resources and guide their development. The 8-fold increase in the cultivated acreage from 12,894 ha. in 1973 to 96,704 ha. in 1988, the 10-fold increase in population from 179,100 in 1968 to 1,748,804 in 1988, the continuously stable high cost of food imports during the past decade of above 3.0 billion dirhams ($ US 0.8 billion) a year and the 22-fold increase in water consumption from 172 MCM/a in 1968 to 3659 MCM/a. in 1989, sum up the water resource problem of the Emirates. As a result, water-tables have been receding continuously, groundwater salinity rising both in inland and coastal aquifers, and the shallow fresh water aquifer in the Quaternary deposits has been depleted in many parts of the piedmont (gravel) plains. Given this critical state of the groundwater resources, the preclusive cost of desalinated water to its application to agriculture and the ill-advised outlets to which every possible water resource developed is put, an urgent rethinking of water policies and development is vital. Such rethinking should set water-related priorities right, should resist all temptations, for reasons of national security, to imports of foreign water, and should be within the context of well-intentioned efforts towards achieving food security, through specialized agriculture, as much as is naturally possible.

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Ni, Shuinear Sinead. "Irish travellers : ethnolect, alliance, control". Thesis, University of Greenwich, 2003. http://gala.gre.ac.uk/6299/.

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Khan, Muhammad Jaffar. "Gut microbiota in obesity of different aetiology : cause or effect?" Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/6299/.

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Baccolini, Carlotta. "Alcune proprietà dei poliedri". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/6299/.

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Guan, Mingfu. "Geomorphic impacts of rapid sediment-laden flows through computational modelling". Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/6299/.

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Outburst floods are one of the most catastrophic natural hazards for populations and infrastructure. They are usually generated from storm runoff, rapid melting of glacial ice or man-made and natural dam breaks, such as river dikes, volcanic debris dams and landslide damns etc. Such high-magnitude sudden onset floods generally comprise of an advancing intense kinematic water wave that can induce considerable sediment transport. Therefore, the exploration and investigation of sediment-laden outburst floods cannot be limited solely to water flow but must also include the flood-induced sediment transport. Understanding the complex flow-bed interaction process in large (field) scale outburst floods is still limited, not least due to a lack of well-constrained field data, but also because consensus on appropriate modelling schemes has yet to be decided. In recent years, attention has focussed on the numerical models capable of describing the process of erosion, transport and deposition in such flows and they are now at a point at which they provide useful quantitative data. Although the "exact" measure of bed change is still unattainable the numerical models enhance and improve insights into large outburst flood events. In order to model and better understand heavily sediment-laden flows and resulting geomorphic impacts, this thesis adopts a layer-based conceptual model which separates the system into an active bed layer, a water sediment mixed sheet flow layer and a suspension layer. Correspondingly, a layer-based hydro-morphodynamic model is proposed fully considering both bedload and suspended load based on shallow water theory. The model system is primarily composed of a combination of three modules: (1) a hydrodynamic module; (2) a sediment transport module; and (3) a morphological evolution module. In the thesis, firstly, a robust hydrodynamic model is proposed and tested including addressing the source terms and wetting/drying issues for application to irregular beds. Then based on the robust hydrodynamic model, a layer-based morphodynamic model is developed and solved numerically by an advanced second-order Godunov-type finite volume method. A series of theoretical and experimental tests are applied to validate the model in terms of both hydrodynamic and morphodynamic aspects. The results of these tests show that the developed models can predict the hydrodynamic and morphodynamic process effectively with good agreement with theoretical and experimental results. To demonstrate a real application, a full-scale volcano-induced jökulhlaup or glacial outburst flood (GLOF) at Sólheimajökull, Iceland is reproduced by the proposed model. The simulation of the sediment-laden outburst flood is shown to perform well, with further insights into the flow-bed interaction obtained from the modelling output. These results are beneficial to flood risk management and hazard prevention and mitigation.

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Cassano, Rosangela <1983&gt. "Il potere di esternazione dei presidenti di assemblea parlamentare". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6299/.

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Il tema relativo al potere di esternazione del Presidente di Assemblea parlamentare rappresenta un aspetto problematico del diritto costituzionale a causa delle sue diverse implicazioni nonché delle numerose intersezioni tra dato costituzionale e legislativo, dottrina e prassi configurando, dunque, un ambito di ricerca di indubbia rilevanza e attualità all’interno del dibattito costituzionalistico.È chiaro che l’analisi di tale problematica necessita dell’assunzione di un punto di vista che non potrà essere strettamente tecnico-giuridica, ma che necessariamente dovrà confrontarsi con elementi della prassi politico-costituzionale.
The issue related to the power of externalization of the Assembly's President represents a problematic aspect of constitutional law due to its different implications and the numerous intersections between constitutional and legislative fact as well, and also doctrine and praxis configuring, so, it is an environment of research made by an undoubtful relevance and actuality of the internal constitutionalist debate. It's clear that the analysis about this statement needs the assuming of a point of view which won't can be just strictly technical -juridical but also and necessarily will have to relate with the elements of the political-constitutional praxis.

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Chen, Ruiqi. "Implications of PI3K/AKT inhibition on REST protein stability and neuroendocrine prostate cancer". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62099.

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Treatment-induced neuroendocrine (NE) prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer (PCa) that can arise as a consequence of rigorous androgen receptor pathway inhibition (ARPI) therapies now used to treat castration resistant disease (CRPC). While the PI3K/AKT pathway has been investigated as a co-therapeutic target with ARPI for advanced prostate adenocarcinoma, whether this strategy has implications on t-NEPC progression remains unknown. Findings from this work indicate that PI3K/AKT inhibition alone reduces protein expression of the RE-1 silencing transcription factor (REST) and induces multiple NE markers in PCa cells. The loss of REST by PI3K/AKT inhibition is through protein degradation mediated by the E3-ubiquitin ligase β-TRCP and REST phosphorylations at the S1024, S1027, and S1030 sites. Since AR inhibition was previously reported to deplete REST, results from this project reveal that the combined inhibition of PI3K/AKT and AR further aggravates REST protein reduction. Upon profiling the transcriptomes of AKT inhibition, AR inhibition, and AKT/AR co-inhibition in the LNCaP cell model, Gene Set Enrichment Analysis (GSEA) shows that these transcriptomes are highly correlated with the REST-regulated gene signature. Co-targeting AKT and AR resulted in an even higher correlation comparing to those of single treatment. Comparing these transcriptomes to the RNA-seq gene signature of t-NEPC patients by GSEA, it was observed that adding AKT inhibition to AR blockade enhanced the expression of neurogenesis-related genes and resulted in a stronger and broader upregulation of REST-regulated genes specific to t-NEPC. Collectively, these results indicate that AKT pathway inhibition can induce NE transdifferentiation in PCa cells via REST protein degradation. It delineates a potential risk for the AR and PI3K/AKT co-targeting strategy as it may further facilitate t-NEPC development.
Medicine, Faculty of
Experimental Medicine, Division of
Medicine, Department of
Graduate

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Robertson, Anne Burnett. "Fluorescent implantable elastomer tags for the measurement of oxygen in insects". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62399.

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Implantable fibre-optic probes are commonly used to measure the oxygen partial pressure (PO₂) within the haemolymph and tissues of insects, but they are highly invasive and traumatic. Furthermore, they can only measure the PO₂ of one spot of the insect’s body at a time. The objective of this thesis was to develop Fluorescent Implantable Elastomer Tags (FIETs) as an alternative to fibre-optic probes. These FIETs were characterized in terms of their uniformity in size, response to PO₂ and photodegradation. I assessed their viability for in vivo measurements by testing them in an autofluorescent system in situ. I constructed a microfluidic chip to produce the FIETs, and characterized their uniformity. To establish the FIETs response to PO2, they were exposed to oxygen (O₂) gas in nitrogen, ranging from 0 to 0.2 atm O₂. Holding the FIETs within steady-state environments of 0, 0.1 and 0.2 atm O2 and constantly illuminating them for 60 seconds with the excitation light source determined the degree of photodegradation. The FIETs were tested within an autofluorescent system by creating an O₂ gradient within a block of 0.5% (w/v) agar. My results indicate that 72% of the emulsions produced by the microfluidic chip are highly uniform when 1% sodium dodecyl sulfate (SDS) in water is used as the continuous phase. In comparison, only 55% of emulsions are highly uniform when 5% Kolliphor in water is used. FIET diameters ranged from 110 – 401 μm for 1% SDS and 67-120 μm for 5% Kolliphor. The FIETs exhibit a linear response to PO₂ (R²=0.963), which is improved when fluorescence is normalized to fluorescence in anoxia (R²=0.983). Photodegradation occurred over 60 seconds, causing a 31.6%, 6.1% and 359.7% drift in measured PO₂ within 0.2, 0.1 and 0.02 atm O₂ respectively. The FIETs were able to detect an O₂ gradient within 0.5% agar. These results suggest that the FIETs are a viable option for measuring O₂ in insects in vivo, although improvements can be made to the uniformity and photostability of the FIETS. Future work should focus on the FIETs response to confounding factors such as temperature.
Science, Faculty of
Zoology, Department of
Graduate

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Mössenböck, Hanspeter, a cura di. Modular Programming Languages. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2.

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Dandekar, Thomas, e Meik Kunz. Bioinformatik. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62399-2.

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Hilgert, Ingrid, e Joachim Hilgert. Mathematik – ein Reiseführer. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62599-6.

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Saka, Abdelmjid, Jean-Yves Choley, Jamel Louati, Zakaria Chalh, Maher Barkallah, Mohammed Alfidi, Mounir Ben Amar, Fakher Chaari e Mohamed Haddar, a cura di. Advances in Integrated Design and Production. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62199-5.

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Hammouch, Zakia, Hemen Dutta, Said Melliani e Michael Ruzhansky, a cura di. Nonlinear Analysis: Problems, Applications and Computational Methods. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-62299-2.

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Rupakhety, Rajesh, e Símon Ólafsson, a cura di. Earthquake Engineering and Structural Dynamics in Memory of Ragnar Sigbjörnsson. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-62099-2.

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Grassi, Walter. Heat Pumps. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-62199-9.

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Hameurlain, Abdelkader, e A. Min Tjoa, a cura di. Transactions on Large-Scale Data- and Knowledge-Centered Systems XLIII. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-662-62199-8.

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Baldi, Antonio, John M. Considine, Simon Quinn e Xavier Balandraud, a cura di. Residual Stress, Thermomechanics & Infrared Imaging, Hybrid Techniques and Inverse Problems, Volume 8. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-62899-8.

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Alonso-Betanzos, Amparo, Bertha Guijarro-Berdiñas, Verónica Bolón-Canedo, Elena Hernández-Pereira, Oscar Fontenla-Romero, David Camacho, Juan Ramón Rabuñal et al., a cura di. Advances in Artificial Intelligence. Cham: Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-62799-6.

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Goos, Gerhard. "From programming languages to program construction". In Lecture Notes in Computer Science, 1–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_27.

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Gough, K. John. "Multi-language, multi-target compiler development: Evolution of the Gardens Point compiler project". In Lecture Notes in Computer Science, 17–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_28.

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Gough, K. John, e Herbert Klaeren. "Executable assertions and separate compilation". In Lecture Notes in Computer Science, 41–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_29.

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Kistler, Thomas. "Dynamic runtime optimization". In Lecture Notes in Computer Science, 53–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_30.

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Collin, Suzanne, Dominique Colnet e Olivier Zendra. "Type inference for late binding: The SmallEiffel Compiler". In Lecture Notes in Computer Science, 67–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_31.

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Supcik, Jacques, e Moira C. Norrie. "An object-oriented database programming environment for Oberon". In Lecture Notes in Computer Science, 82–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_32.

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Knasmüller, Markus. "Adding persistence to the Oberon-System". In Lecture Notes in Computer Science, 97–111. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_33.

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Weck, Wolfgang. "An abstract data type for freezable lists and DAGs". In Lecture Notes in Computer Science, 112–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_34.

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Puntigam, Franz. "Types that reflect changes of object usability". In Lecture Notes in Computer Science, 125–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_35.

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Roe, Paul, e Clemens Szyperski. "Lightweight parametric polymorphism for Oberon". In Lecture Notes in Computer Science, 140–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/3-540-62599-2_36.

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Atti di convegni sul tema "62F99"

Zhu, W. D., e Y. Chen. "Forced Response of Translating Media With Variable Length and Tension: Application to High-Speed Elevators". In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-62199.

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The lateral response of vertically translating media with variable length and tension, subjected to general initial conditions and external excitation, are determined. The translating media are modeled as a taut string and tensioned beams with pinned and fixed boundaries. In each model a rigid body is attached to the lower end of the medium and has a prescribed displacement along the horizontal direction. The rate of change of the energy of the translating medium is analyzed from the control volume and system viewpoints. The models are used to predict the forced response of a moving cable in a high-speed elevator. Three spatial discretization schemes are used to calculate the response and shown to yield the same results. The convergence of the solution for each model is investigated. The approximate solution for the string model with constant tension is compared with its exact solution from the wave method.

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Dalquist, Stephanie, e Timothy Gutowski. "Life Cycle Analysis of Conventional Manufacturing Techniques: Sand Casting". In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-62599.

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Conventional manufacturing techniques have not been subject to much scrutiny by industrial ecologists to date. Many newer techniques and products draw more attention as they rise quickly from research to global scales, amplifying their environmental consequences. Despite the presence of new technologies and increased overseas production, casting activity continues to have a strong presence in the US, and represents a stable component in the national economy. Data from the US government, US industry groups, and UK mass balance profiles facilitate an understanding of sand casting and comparison across manufacturing processes. The figures in the US and UK are similar in terms of diversity of metals (where the US is 72%, 13%, 10% and the UK 76%, 13%, 8% for iron, aluminum, and steel, respectively), energy per ton of saleable cast metal (10.1 and 9.3 million Btu/ton in the US and UK), and overall emissions, with notable similarities in benzene and particulate emissions. One notable discrepancy is in sand use, where the US sends to waste 0.5 tons of sand per ton of cast metal, whereas the UK sends 0.25 tons to landfill.

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Wheeley, Chad, e Pedro J. Mago. "A Methodology to Conduct a Combined Heating and Power System Assessment and Feasibility Study for Industrial Manufacturing Facilities". In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62299.

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This paper considers combined heat and power (CHP) systems based on topping cycles only, in which electricity is generated by a prime mover and heat is then recovered from the exhaust and utilized to offset all or a portion of the facility’s process and/or space heating requirements.. The objective of this paper is to develop a methodology to perform a topping cycle CHP assessment and feasibility study for industrial manufacturing facilities. In order to determine the best and most viable option for the facility in question, the proposed methodology can be used to size different systems which utilize diverse technologies and fuel sources, perform an economic analysis of each proposed option, and then compare the benefits and setbacks of each type of CHP system considered. The calculations performed in the economic analysis will then provide a broad insight as to which proposed system will show the best payback if installed. Examples are presented in this paper that describe in detail the application of this methodology, from equipment selection and sizing through economic analyses and proposed system comparisons, which is recommended for use in order to determine the most economically feasible CHP system for an industrial manufacturing facility.

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Pasangulapati, V., N. R. Kesana, G. Sharma, F. W. Chambers, M. E. McNally e R. M. Hoffman. "Computational Study of Slurry Flow in Pipes to Determine Profiles Sensed in Near Infrared Slurry Measurements". In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62799.

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It is desired to perform accurate Near Infrared sensor measurements of slurries flowing in pipes leaving large batch reactors. A concern with these measurements is the degree to which the slurry sensed is representative of the material in the reactor and flowing through the pipe. Computational Fluid Dynamics (CFD) has been applied to the flow in the pipe to determine the flow fields and the concentration profiles seen by the sensors. The slurry was comprised of a xylene liquid phase and an ADP (2-amino-4, 6-dimethylpyrimidine) solid phase with a density ratio of 1.7. Computations were performed for a horizontal pipe with diameter 50.8 mm, length 2.032 m, and 1.76 m/s and 3.26 m/s mixture velocities. The corresponding pipe Reynolds numbers were 1.19E+05 and 2.21E+05. The flow through a slotted cylindrical probe inserted radially in the pipe also was considered. Spherical slurry particles with diameters from 10 μm to 1000 μm were considered with solid volume fractions of 12%, 24%, and 35%. Computations were performed with ANSYS FLUENT 12 software using the Realizable k-ε turbulence model and the enhanced wall treatment function. Comparisons of computed vertical profiles of solid volume fraction to results in the literature showed good agreement. Symmetric, nearly flat solid volume fraction profiles were observed for 38 μm particles for all three initial solid volume fractions. Asymmetric solid volume fraction profiles with greater values toward the bottom were observed for the larger particles. Changes in the profiles of turbulent kinetic energy also were observed. These changes are important for optical measurements which depend upon the mean concentration profiles as well as the turbulent motion of the slurry particles.

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Zhao, Min, Shikai Yang e Daoyong Yang. "Performance Evaluation of Hybrid Thermal-Solvent Injection in a Post-CHOPS Reservoir With Consideration of Wormhole Network". In ASME 2021 40th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/omae2021-62999.

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Abstract In this paper, techniques have been developed to evaluate performance of thermal, solvents, and hybrid thermal-solvent processes in a post-CHOPS reservoir with consideration of wormhole network. With the experimentally determined properties of injected gases and reservoir fluids, history matching is accomplished for the reservoir geological model conditioned to the fluid and sand production profiles together with pressure. Meanwhile, the wormhole network is characterized with the newly developed pressure-gradient-based (PGB) sand failure criterion. Once the history matching is completed, the calibrated reservoir geological model is then employed to evaluate performance of thermal, solvents, and hybrid thermal-solvent processes under various conditions. It is found that huff-n-puff processes have a very good performance on enhancing oil recovery when wormhole network is fully generated and propagated. Among all solvent-based methods, pure CO2 huff-n-puff process shows a better performance than flue gas, while the addition of alkane solvents leads to a higher oil recovery compared with CO2 only method. Since the addition of C3H8 and n-C4H10 will significantly decrease the heavy oil viscosity and enhance the swelling factor, all hybrid thermal-solvent injection achieves high oil recovery by taking the advantage of both hot steam and solvents injection.

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Bhandiwad, M. S., e T. Nasar. "Drag Coefficient for Porous Screen in a Non-Oscillating Perpendicular to Plane-in Flow". In ASME 2021 40th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/omae2021-62799.

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Abstract The flow-through porous bodies/structure is one of the more advanced research in the area of energy dissipation in coastal and civil engineering fields. The experiments on the determination of drag coefficient of screens with varying porosities and for the range of flow velocities lead to explore damping ratio in a typical fluid-structure interaction problem. An experimental study has been carried out to assess the drag coefficient of the porous screens as suggested by Keulegan, G. H (1968) [3]. Six different screens with porosities of 4.4%, 6.8%, 9.2% 15%, 20% and 25% are considered. In the experiments, water with a known head from one tank is allowed to flow through a pipe equipped with porous screens into the other tank. Based on the experimental observation, the correlation between Reynolds number and drag coefficient is obtained for all porous screens. The effect of damping nature (damping ratio) of the screen for a particular range of Reynolds number has been explored. As the Reynolds number increases, the drag coefficient decreases with increasing the porosity of the screen. Further, it is understood that the value of the damping ratio decreases with an increasing relative head (H/L).

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Ignatenko, Yaroslav, Andrey Gavrilov e Oleg Bocharov. "Helical Flow of Drilling Mud With Cuttings in a Vertical Well". In ASME 2021 40th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/omae2021-62699.

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Abstract The paper presents the results of an investigation into drilling mud flow with cuttings in a vertical well. The drilling mud rheology was described with the Herschel-Bulkley model. The axial Reynolds number was around 1000, the flow regime changing together with drill pipe RPM. The investigation covered the flow’s structures, integral parameters and cuttings transport in relation to drill pipe RPM and rate of penetration (ROP). In the laminar flow, most of the particles were localized in the quasi-solid region to move together with the last; the integral parameters had little dependence on drill pipe RPM increase. Increasing drill pipe RPM resulted in formation of the Görtler vortices near the channel’s external and internal walls, whose interaction led to the formation of smaller eddies converting the flow into a turbulent one. Due to the turbulence dispersion, the region taken by the particles widened. Particles suppress the vortex intensity near the channel’s external wall. Under the conditions described, increasing drill pipe RPM and ROP resulted in higher pressure drops and lower transport efficiency.

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Uehara Sasaki, Humberto A., André S. Sandes Ianagui, Pedro Cardozo de Mello e Eduardo Aoun Tannuri. "Digital Twin of a Maneuvering Ship: Real-Time Estimation of Derivatives and Resistance Coefficient Based on Motion Sensor". In ASME 2021 40th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/omae2021-62899.

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Abstract Retrieving certain hydrodynamics coefficients from a marine craft during a maneuver can be useful for various reasons, such as the validation of project specifications or the rapid verification of structural changes that could impact the vessel movement. Intended to estimate some of these parameters, the present work proposes a method purely based on traditional Extended Kalman Filter (EKF) focused for limited drift angles. Albeit not posing as a replacement to conventional estimations, such as from Computer Fluid Dynamics (CFD) — which solve equations in order of millions — and experimental tests — with its time-consuming preparation setups and post-analyses — the method can possibly present itself as a convenient and quicky technique to estimate the hydrodynamics coefficients in real time, as each iteration resorts only into a few dozen of equations. Preliminary results in the simulated environment called pyDyna — a python version of the Numerical Offshore Tank ship maneuvering simulator — indicate this procedure is faster along with an acceptable margin of accuracy, possibly pointing as a feature for future digital twin applications.

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Kabelac, S., e K. B. Anoop. "Experimental Convective Heat Transfer With Nanofluids". In ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2008. http://dx.doi.org/10.1115/icnmm2008-62099.

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Nanofluids are colloidal suspensions with nano-sized particles (<100nm) dispersed in a base fluid. From literature it is seen that these fluids exhibit better heat transfer characteristics. In our present work, thermal conductivity and the forced convective heat transfer coefficient of an alumina-water nanofluid is investigated. Thermal conductivity is measured by a steady state method using a Guarded Hot Plate apparatus customized for liquids. Forced convective heat transfer characteristics are evaluated with help of a test loop under constant heat flux condition. Controlled experiments under turbulent flow regime are carried out using two particle concentrations (0.5vol% and 1vol %). Experimental results show that, thermal conductivity of nanofluids increases with concentration, but the heat transfer coefficient in the turbulent regime does not exhibit any remarkable increase above measurement uncertainty.

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Tamayol, A., M. Bahrami e P. Taheri. "Slip-Flow Pressure Drop in Microchannels of General Cross-Section". In ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2008. http://dx.doi.org/10.1115/icnmm2008-62199.

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In the present study, a compact analytical model is developed to determine the pressure drop of fully-developed, incompressible, and constant properties slip-flow through arbitrary cross-section microchannels. An averaged first-order Maxwell slip boundary condition is considered. Introducing a relative velocity, the difference between the bulk flow and the boundary velocities, the axial momentum reduces to the Poisson’s equation with homogeneous boundary condition. Square root of area is selected as the characteristic length scale. Bahrami et al.’s model, which was developed no-slip boundary condition, is extended to cover the slip-flow regime in this study. The proposed model is a function of geometrical parameters of the channel: cross-sectional area, perimeter, polar moment of inertia and the Knudsen number. The model is successfully validated against existing numerical and experimental data from different sources in the literature for several shapes, including: circular, rectangular, trapezoidal, and double-trapezoidal cross-sections and a variety of gases such as: nitrogen, argon, and helium.

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