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Letteratura scientifica selezionata sul tema "616.831 1"

Autore: Grafiati

Pubblicato: 8 giugno 2024

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Articoli di riviste sul tema "616.831 1":

Rektiansyah, Rahmat Robbi, e Ilmiawan Auwalin. "Analisis Dampak Kesadaran Halal dan Label Halal terhadap Niat Beli Mie Instan Korea Pada Remaja di Sumenep Melalui Sikap". Jurnal Ekonomi Syariah Teori dan Terapan 9, n. 5 (30 settembre 2022): 600–616. http://dx.doi.org/10.20473/vol9iss20225pp600-616.

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ABSTRAK Tujuan dilangsungkannya sebuah penelitian ini ialah untuk mengkaji pengaruh kesadaran halal dan label halal terhadap niat beli mie instan Korea pada remaja di Sumenep melalui sikap. Metode penelitian yang digunakan yaitu kuantitatif dengan menggunakan data primer. Sampel yang digunakan yaitu 100 responden yang belum pernah membeli mie instan Korea. Pengujian menggunakan analisis SEM-PLS dengan konstruk yang menunjukkan semua konstruk mempunyai hasil yang valid, sehingga dilanjutkan pengujian pada hubungan antar variabelnya. Secara langsung kesadaran halal berpengaruh signifikan terhadap sikap, namun kesadaran halal tidak berpengaruh signifikan terhadap niat beli. Label halal berpengaruh secara signifikan t atas niat beli, namun label halal tidak berpengaruh signifikan terhadap sikap, dan sikap berpengaruh secara signifikan atas niat beli. Secara tidak langsung, kesadaran halal berpengaruh signifikan terhadap niat beli jika melalui sikap, sedangkan label halal tidak berpengaruh signifikan terhadap niat beli jika melalui sikap. Penelitian ini hanya berfokus terhadap remaja generasi Z usia 13-23 tahun di Sumenep yang belum pernah membeli mie instan Korea. Adapun saran pada penelitian ini adalah remaja generasi Z di Sumenep diharapkan lebih memperhatikan dan peduli terhadap kehalalan suatu produk yang dikonsumsi, dan bagi peneliti selanjutnya diharapkan meneliti hal serupa dengan mengganti objek dan tempat penelitian. Kata Kunci: Kesadaran Halal, Label Halal, Niat Beli, Sikap. ABSTRACT The purpose of this research is to examine the effect of halal awareness and halal label on the intention to buy Korean instant noodles in adolescents in Sumenep through attitudes. The research method used is quantitative using primary data. The sample used is 100 respondents who have never bought Korean instant noodles. The test uses SEM-PLS analysis with constructs that show all constructs have valid results, so that testing continues on the relationship between the variables. Halal awareness directly has a significant effect on attitudes, but halal awareness has no significant effect on purchase intention. Halal labels have a significant effect on purchase intention, but halal labels have no significant effect on attitudes, and attitudes have a significant effect on purchase intentions. Indirectly, halal awareness has a significant effect on purchase intention if it is through attitude, while the halal label has no significant effect on purchase intention if it is through attitude. This study only focuses on Generation Z teenagers aged 13-23 years in Sumenep who have never bought Korean instant noodles. The suggestion in this study is that Generation Z teenagers in Sumenep are expected to pay more attention and care about the halalness of a product that is consumed, and for future researchers it is expected to examine similar things by changing the object and place of research. Keywords: Halal Awareness, Halal Labels, Purchase Intention. Attitudes. DAFTAR PUSTAKA Abd Rahman, A., Asrarhaghighi, E., & Ab Rahman, S. (2015). Consumers and halal cosmetic products: Knowledge, religiosity, attitude and intention. Journal of Islamic Marketing, 6(1), 148–163. https://doi.org/10.1108/JIMA-09-2013-0068 Adisumarto, H. (2000). Hukum perusahaan mengenai hak atas kepemilikan intelektual (Hak cipta, hak paten, hak merek). Bandung: Mandar Magu. Adiwarman, K. (2010). Ekonomi mikro Islam. Jakarta: PT. RajaGrafindo Persada. Ahaari, J. A. N., & Arifin, N. S. M. (2010). Dimension halal purchase intention: A preliminary study. International Review of Business Research Papers, 6 (4), 444–456. Aliman, N.K. dan Othman, M. N. (2007). Purchasing local and foreign brands: What product attributes matter? 13th astutiAsia Pacific Management Conference, Melbourne, Australia, 400–411. Ambali, A. R., & Bakar, A. N. (2014). People’s awareness on halal foods and products: Potential issues for policy-makers. Procedia - Social and Behavioral Sciences, 121(September 2012), 3–25. https://doi.org/10.1016/j.sbspro.2014.01.1104 Astuti, Y., & Asih, D. (2021). Country of origin, religiosity and halal awareness: A case study of purchase intention of Korean food. Journal of Asian Finance, Economics and Business, 8(4), 0413–0421. https://doi.org/10.13106/jafeb.2021.vol8.no4.0413 Awan, H. M., Siddiquei, A. N., & Haider, Z. (2015). Factors affecting Halal purchase intention – evidence from Pakistan’s halal food sector. Management Research Review, 38(6), 640–660. https://doi.org/10.1108/mrr-01-2014-0022 Azam, A. (2016). An empirical study on non-Muslim’s packaged halal food manufacturers . Journal of Islamic Marketing, 7(4), 441–460. https://doi.org/10.1108/jima-12-2014-0084 Aziz, Y. A., & Chok, N. V. (2013). The role of halal awareness, halal certification, and marketing components in determining halal purchase intention among non-Muslims in Malaysia: A Structural equation modeling approach. Journal of International Food and Agribusiness Marketing, 25(1), 1–23. https://doi.org/10.1080/08974438.2013.723997 Aziz, Y. A., Vui, C. N., Yuhanis, A. A., & Chok, N. V. (2012). The role of halal awareness and halal certification in influencing non-Muslims’ purchase intention. In Proceedings of the 3rd International Conference on Business and Economic Research (3rd ICBER 2012), March, 1819–1830. BPS. (2021). Hasil sensus penduduk 2020 jumlah penduduk Kabupaten Sumenep (Issue 01). Briliana, V., & Mursito, N. (2017). Exploring antecedents and consequences of Indonesian Muslim youths’ attitude towards halal cosmetic products: A case study in Jakarta. Asia Pacific Management Review, 22(4), 176–184. https://doi.org/10.1016/j.apmrv.2017.07.012 Garg, P., & Joshi, R. (2018). Purchase intention of “Halal” brands in India: the mediating effect of attitude. Journal of Islamic Marketing, 9(3), 683–694. https://doi.org/10.1108/JIMA-11-2017-0125 Hair, J., Black, W., Babin, B., & Anderson, R. (2010). Multivariate data analysis: A global perspective. Pearson Education Hasan, H. (2016). A study on awareness and perception towards halal foods among Muslim students in Kota Kinabalu, Sabah. Australia-Middle East Conference on Business and Social Sciences, 803–804. Hendradewi, S., Mustika, A., & Darsiah, A. (2021). Pengaruh kesadaran halal dan label halal terhadap minat beli mie instan Korea pada remaja sekolah di Jakarta. Jurnal Ilmiah Pariwisata, 26(2), 204–212. https://doi.org/10.30647/jip.v26i2.1510 Izzuddin, A. (2018). Pengaruh label halal, kesadaran halal, dan bahan makanan terhadap minat beli makanan kuliner. Jurnal Penelitian Ipteks, 3(2), 100–114. https://doi.org/10.32528/ipteks.v3i2.1886 Kotler, P. (2008). Manajemen pemasaran (Edisi terjemahan). Erlangga: Jakarta. Mukhtar, A., & Butt, M. M. (2012). Intention to choose Halal products: The role of religiosity. Journal of Islamic Marketing, 3(2), 108–120. https://doi.org/10.1108/17590831211232519 Nisrina, D., Widodo, I. A., Larassari, I. B., Rahmaji, F., Kinanthi, G., & Adi, H. (2020). Studi tentang pengaruh budaya Korea pada penggemar K-Pop. Jurnal Penelitian Humaniora, 21(1), 78–88. Rambe, Y., & Afifuddin, S. (2012). Pengaruh pencantuman label halal pada kemasan mie instan terhadap minat pembelian masyarakat Muslim (Studi kasus pada mahasiswa Universitas Al-washliyah, Medan). Jurnal Ekonomi dan Keuangan, 1(1), 14866. Rangkuti. (2010). Pengaruh labelisasi halal terhadap keputusan pembelian produk makanan dalam kemasan (Snack merek Chitato) pada mahasiswa fakultas hukum Universitas Muhammadiyah Sumatera Utara). Skripsi tidak dipublikasikan. Medan: Universitas Sumatera Utara. Rochmanto, B. Al. (2014). Pengaruh pengetahuan produk dan norma religius tehadap sikap konsumen dalam niat mengkonsumsi produk makanan dan minuman halal. Diponegoro Journal of Management, 4(1), 280-291. Sarwono, S. ., & Meinarno, E. . (2009). Psikologi remaja. Surabaya: Raja Grafindo Persada. Schiffman, L. G., & Wisenblit, J. (2019). Consumer behavior. Harlow, United Kingdom: Pearson Education Limited. Setiawati, L. M., Chairy, C., & Syahrivar, J. (2019). Factors affecting the intention to buy halal food by the millennial generation: The mediating role of attitude. DeReMa (Development Research of Management): Jurnal Manajemen, 14(2), 175. https://doi.org/10.19166/derema.v14i2.1738 Shafie, S., & Othman, M. N. (2008). Halal certification: An international marketing issues and challenges. http://www.ncbi.nlm.nih.gov/pubmed/12568103 Shim, D. (2006). Hybridity and the rise of Korean popular culture in Asia. Media, Culture and Society, 28(1), 25–44. https://doi.org/10.1177/0163443706059278 Sudarsono, H., & Nugrohowati, R. N. I. (2020). Determinants of the intention to consume halal food, cosmetics and pharmaceutical products. Journal of Asian Finance, Economics and Business, 7(10), 831–841. https://doi.org/10.13106/jafeb.2020.vol7.no10.831 Sugiyono. (2006). Metode penelitian bisnis. Bandung: CV. Alfabeta. Windiana, L., & Putri, D. N. (2021). Pengaruh logo halal terhadap sikap dan minat beli konsumen UMM Bakery. Jurnal Ekonomi Pertanian dan Agribisnis (JEPA), 5, 1206–1216. https://doi.org/10.21776/ub.jepa.2021.005.0224. Yuliani, F. (2021). Pengaruh label halal dan citra merek terhadap keputusan pembelian produk kosmetik wardah pada rahmah cosmetic Banjarmasin (Studi kasus pada konsumen loyal produk wardah di Banjarmasin Selatan). Skripsi tidak dipublikasikan. Banjarmasin: Universitas Islam Kalimantan MAB.

Di Carlo, Antonio, Leonardo Bellino, Domenico Consoli, Fabio Mori, Augusto Zaninelli, Marzia Baldereschi, Alessandro Cattarinussi et al. "Prevalence of atrial fibrillation in the Italian elderly population and projections from 2020 to 2060 for Italy and the European Union: the FAI Project". EP Europace 21, n. 10 (6 giugno 2019): 1468–75. http://dx.doi.org/10.1093/europace/euz141.

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Abstract Aims To estimate prevalence of atrial fibrillation (AF) in a representative sample of the Italian elderly population, projecting figures for Italy and the European Union. Methods and results A cross-sectional examination of all subjects aged 65+ years from three general practices in Northern, Central, and Southern Italy started in 2016. Participants were administered a systematic and an opportunistic screening, followed by clinical and electrocardiogram confirmation. The study sample included 6016 subjects. Excluding 235 non-eligible, among the remaining 5781 participation was 78.3%, which left 4528 participants (mean age 74.5 ± 6.8 years, 47.2% men). Prevalence of AF was 7.3% [95% confidence intervals (CI) 6.6–8.1], higher in men and with advancing age (6.6% from systematic plus 0.7% from opportunistic screening). Using prevalence figures, Italian elderly having AF in 2016 were estimated at ∼1 081 000 (95% CI 786 000–1 482 000). Considering stable prevalence, this number will increase by 75% to ∼1 892 000 in 2060 (95% CI 1 378 000–2 579 000). European Union elderly having AF in 2016 were estimated at ∼7 617 000 (95% CI 5 530 000–10 460 000), increasing by 89% to ∼14 401 000 in 2060 (95% CI 10 489 000–19 647 000). In 2016, subjects aged 80+ years represented 53.5% of cases in Italy and 51.2% in the European Union; in 2060, 69.6% and 65.2%, respectively. Conclusions Our findings indicate a high burden of AF in coming decades, especially among the oldest-old, who carry the higher AF-related risk of stroke and medical complications.

Speak, Thomas H., Mark A. Blitz, Daniel Stone e Paul W. Seakins. "A new instrument for time-resolved measurement of HO<sub>2</sub> radicals". Atmospheric Measurement Techniques 13, n. 2 (20 febbraio 2020): 839–52. http://dx.doi.org/10.5194/amt-13-839-2020.

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Abstract. OH and HO2 radicals are closely coupled in the atmospheric oxidation and combustion of volatile organic compounds (VOCs). Simultaneous measurement of HO2 yields and OH kinetics can provide the ability to assign site-specific rate coefficients that are important for understanding the oxidation mechanisms of VOCs. By coupling a fluorescence assay by gaseous expansion (FAGE) laser-induced fluorescence (LIF) detection system for OH and HO2 with a high-pressure laser flash photolysis system, it is possible to accurately measure OH pseudo-1st-order loss processes up to ∼100 000 s−1 and to determine HO2 yields via time-resolved measurements. This time resolution allows discrimination between primary HO2 from the target reaction and secondary production from side reactions. The apparatus was characterized by measuring yields from the reactions of OH with H2O2 (1:1 link between OH and HO2), with C2H4∕O2 (where secondary chemistry can generate HO2), with C2H6∕O2 (where there should be zero HO2 yield), and with CH3OH∕O2 (where there is a well-defined HO2 yield). As an application of the new instrument, the reaction of OH with n-butanol has been studied at 293 and 616 K. The bimolecular rate coefficient at 293 K, (9.24±0.21)×10-12 cm3 molec.−1 s−1, is in good agreement with recent literature, verifying that this instrument can measure accurate OH kinetics. At 616 K the regeneration of OH in the absence of O2, from the decomposition of the β-hydroxy radical, was observed, which allowed the determination of the fraction of OH reacting at the β site (0.23±0.04). Direct observation of the HO2 product in the presence of oxygen has allowed the assignment of the α-branching fractions (0.57±0.06) at 293 K and (0.54±0.04) at 616 K, again in good agreement with recent literature; branching ratios are key to modelling the ignition delay times of this potential “drop-in” biofuel.

Johnson, Drew. "Type 1 Brugada pattern induced by DKA". Endocrinology and Disorders 6, n. 1 (7 gennaio 2022): 01–02. http://dx.doi.org/10.31579/2640-1045/106.

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A 25-year-old man with a past medical history of type 1 diabetes presented to the emergency department with 2 days of progressive abdominal pain, nausea, and vomiting after stopping insulin. His heart rate was 125 and the respiratory rate was 26. The glucose was 832 mg/dl, the potassium was 6.6 mmol/L, the beta-hydroxybutyrate was 111.8 mg/dl, and the pH was 6.95.

Marshall, Chloe. "Brain, behavior and learning in language and reading disorders. Edited by M. Mody and E. Silliman. The Guilford Press, New York, 2008. pp. 400. Price: £33. ISBN 978-1-59385-831-5". Infant and Child Development 18, n. 6 (novembre 2009): 579–81. http://dx.doi.org/10.1002/icd.619.

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Khamiruev, T. N., I. V. Volkov e B. Z. Bazaron. "Line breeding of sheep when creating a new type of Transbaikal breed". Siberian Herald of Agricultural Science 50, n. 2 (28 maggio 2020): 64–74. http://dx.doi.org/10.26898/0370-8799-2020-2-8.

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The role of line breeding in fine-wool sheep husbandry is shown. Productivity indicators of fine-wool sheep of Transbaikal breed of Khangil type, in the conditions of Trans-Baikal Territory are presented. Four inbred lines were created in the Khangil type of Transbaikal breed, which are distinguished by increased indicators of wool and meat productivity, as well as high wool indicators. These are lines No 616, 8351, 8099, 8349. The positive effect of the new lines on the improvement of productive qualities in the herd of fine-wool sheep of Transbaikal breed of Khangil type was revealed. Line-bred rams exceeded their peers in live weight by 0.5–3.5%, amount of washed wool shorn – 7.2–23.8% (p ˂ 0.01), yield of washed wool – 2.2–6.5 abs.%, wool length – 1.0–8.0%, wool coefficient – 1.7–11.5 g per 1 kg of live weight. Moreover, animals of line No 8351 differ from individuals of other lines in the increased density of wool fibers and significantly finer wool (p ˂ 0.05), corresponding to the 64th quality. Lines No 8099 and 8349 are represented by large individuals with high indicators of live weight and wool productivity, lines No 616 and 8351 are characterized by an increased amount of wool shorn combined with good growth and development indicators. Line-bred ewes exceed the breed standard in live weight by 12.5–24.3%, and the amount of shorn washed wool by 33.8– 40.7%. The length of hair was 9.3–9.6 cm, the proportion of animals with fine wool of 64th quality was 80.1–86.0%. The lines are maintained by selection of ewes both related and unrelated to the ram (line extension) that meet the requirements of the desired type and characteristics of the line.

Maddali, L. S., e S. Maddali. "Pattern of malignancies in geriatric patients". Journal of Clinical Oncology 25, n. 18_suppl (20 giugno 2007): 19650. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.19650.

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19650 Background: Information regarding pattern of malignancies in geriatric patients in India is not readily available. Methods: Between 1st January 1999 and 31st December 2006 we encountered 832 geriatric patients among a total of 3748 cases. Analysis was done with respect to age, sex and disease. Results: Geriatric patients constituted 832/3748 (22.20%) of our work load. Males 432 (51.92%) Females 400 (48.08%). Hematologic malignancies 214 (25.72%) Solid tumors 618 (74.28%). male preponderance in Hematologic malignancies 141/214 (66.89%); female preponderance in solid tumors 327/618 (52.91%). Top 7 malignancies: Males (432)-NSCLC 60 (13.89%) Prostate 57 (13.19%) NHL 48 (11.11%) Myeloma 39 (9.03%) CLL 31 (7.18%) HNSCC 30 (6.94%) Colon 26 (6.02%); Females (400)- Breast 147 (36.75%) Ovary 50 (12.50%) Uterus 44 (11.00%) NHL 25 (6.25%) Colon 20 (5.00%) NSCLC 11 (2.75%) CML 10 (2.50%). Age groups: (65–70) yrs-517 (62.13%) males 254, females 263; (71–80) yrs-264 (31.73%) males 152 females 112; (81–90) yrs-48 (5.78%) males 24, females 24; >91yrs-3 (0.36%) males 2 female 1. Top 5 malignancies in each age & sex group: Males, (65–70) yrs, 254: NSCLC 39 NHL 30 Prostate 29 Myeloma 24 Colon 19; (71–80) yrs, 152: Prostate 20 NSCLC 19 NHL 17 CLL 15 HNSCC 14; (81–90) yrs, 24: Prostate 7 Myeloma 2 CLL 2 CML 2 AML 2; Females, (65–70) yrs, 263: Breast 99 Ovary 37 Uterus 30 colon 13 NHL 13; (71–80) yrs, 112: Breast 41 Ovary 12 NHL 11 Uterus 10 CLL 9; (81–90) yrs, 24: Breast 7 Uterus 4 CLL 2 Renal cell carcinoma 2 Ovary 1. Conclusions: Solid tumors are the predominant malignancies in geriatric patients 618/832 (74.28%). B Cell neoplasms constitute bulk of the hematologic neoplasms 173/214 (80.84%). Sarcomas are uncommon 20/832 (2.40%). Important solid tumors: Prostate, NSCLC, Colon and HNSCC in males; Breast, Ovary, Uterus and colon in females. Age group (65–70) yrs is the major group 517/832 (62.13%) followed by significant age group (71–80) yrs 264/832 (31.73%). It is imperative to employ curative strategies for malignancies in this ever expanding population. No significant financial relationships to disclose.

Boote, D. J., I. F. Dennis, P. R. Twentyman, R. J. Osborne, C. Laburte, S. Hensel, J. F. Smyth, M. H. Brampton e N. M. Bleehen. "Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer." Journal of Clinical Oncology 14, n. 2 (febbraio 1996): 610–18. http://dx.doi.org/10.1200/jco.1996.14.2.610.

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PURPOSE To determine the maximum-tolerated dose (MTD) and toxicity of PSC 833 infusion administered with etoposide for 5 days in patients with cancer, and to determine the effect of PSC 833 on etoposide pharmacokinetics. PATIENTS AND METHODS Thirty-five patients were entered onto the study, one of whom was ineligible. Etoposide was delivered from day 1 as a 2-hour infusion over 5 consecutive days at a dose of 75 to 100 mg/m2/d. PSC 833 was administered from day 2 as a 2-hour loading dose and as a 5-day continuous infusion. Doses were escalated from 1 to 2 mg/kg (loading dose) and 1 to 15 mg/kg/d (continuous infusion). RESULTS Thirty-four patients were treated with 53 cycles of PSC 833 and etoposide. Steady-state blood PSC 833 levels more than 1,000 ng/mL were achieved in all patients treated at PSC 833 doses > or = 6.6 mg/kg/d by continuous infusion. Myelosuppression was the most common toxicity. The major dose-related toxicity of PSC 833 was reversible hyperbilirubinemia, which occurred in 83% of cycles. The dose-limiting toxicity of PSC 833 was severe ataxia, which occurred in two of nine patients treated at 12 mg/kg/d and in both of the single patients treated at 13.5 and 15 mg/kg/d. PSC 833 concentrations more than 2,000 ng/mL resulted in an increase in etoposide area under the curve (AUC) of 89%, a decrease in etoposide clearance (Cl) of 45%, a decrease in volume of steady-state distribution (Vss) of 41%, and an insignificant increase in alpha half-life (t 1/2 alpha) and significant increase of beta half-life (t 1/2 beta) of 19% and 77%, respectively. CONCLUSION PSC 833 can be administered in combination with etoposide with acceptable toxicity. The recommended continuous infusion dose of PSC 833 for this schedule is 10 mg/kg/d over 5 days. PSC 833 results in an increase in etoposide exposure and etoposide doses should be reduced in patients receiving PSC 833.

Новіков, Вадим. "СПРОЩЕНА СИСТЕМА ОБЛІКУ І ЗВІТНОСТІ: ІСТОРИЧНИЙ АСПЕКТ". Grail of Science, n. 24 (22 febbraio 2023): 107–9. http://dx.doi.org/10.36074/grail-of-science.17.02.2023.013.

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Суб’єкти малого підприємництва складають найвагомішу частку української економіки. За статистикою у 2021 р. в Україні діяло 1 880 858 (96%) мікропідприємств, 56 969 (3%) малих підприємств, 17 811 (0,9%) середніх підприємств та 610 (0,1%) великих підприємств. Великі підприємства займали 33,7 % у структурі загальної виробленої продукції, середні – 34,4 %, малі – 31,9%, з них мікропідприємства – 18,2%. [3].

Anderson, Gregory J., William T. Roswit, Michael J. Holtzman, James C. Hogg e Stephan F. Van Eeden. "Effect of mechanical deformation of neutrophils on their CD18/ICAM-1-dependent adhesion". Journal of Applied Physiology 91, n. 3 (1 settembre 2001): 1084–90. http://dx.doi.org/10.1152/jappl.2001.91.3.1084.

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Mechanical deformation of polymorphonuclear leukocytes (PMN) changes their expression of the surface adhesion molecule CD11b/CD18. We tested the hypothesis that mechanical deformation of PMN enhances their adhesiveness. Purified human PMN were deformed through either 5- or 3-μm polycarbonate membrane filters and allowed to adhere to 96-well plates coated with human recombinant intercellular adhesion molecule-1 (ICAM-1). Flow cytometric studies showed that deformation of PMN increased CD11b/CD18 expression ( P < 0.01). PMN adhesion to ICAM-1-coated plates was dependent on the magnitude of cell deformation (5 μm, 63.8 ± 8.1%, P < 0.04; 3 μm, 232.4 ± 20.9%, P < 0.01). Priming of PMN (0.5 nM N-formyl-methionyl-leucyl-phenylalanine) before deformation (5 μm) increased PMN adhesion (63.8 ± 8.1 vs. 105.3 ± 16.4%; P < 0.04). Stimulation (5% zymosan-activated plasma) of PMN after deformation resulted in increased adhesion, and the degree of increase was dependent on the magnitude of PMN deformation (stimulation, 50.6 ± 4%; 5-μm filtration and stimulation, 62.9 ± 6.6%; 3-μm filtration and stimulation, 249.9 ± 24.2%; P < 0.01). This study shows that mechanical deformation of PMN causes an increase in PMN adhesiveness to ICAM-1 that was enhanced by both priming of PMN before deformation and stimulation after cell deformation.

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Tesi sul tema "616.831 1":

Abdel-Rahman, Soumaya. "The role of B7-1 molecules in the activation of CD4+ T cells from IL-2 deficient mice". Thesis, Imperial College London, 2001. http://hdl.handle.net/10044/1/8311.

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Hameed, Shaista. "Investigation of the production and isolation of bioactive compounds from cyanobacteria". Thesis, Robert Gordon University, 2013. http://hdl.handle.net/10059/841.

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Due to heavy nutrient load and adverse climate change the occurrence of toxic cyanobacterial blooms have significantly increased during the last decades. Nodularia spumigena is one of the dominant toxic cyanobacteria which produces massive and inherent blooms in brackish water body, the Baltic Sea, particularly in late summer. Nodularia spp. are known to produce nodularins (NOD) and a range of other bioactive peptides such as spumigins and nodulopeptins, all of which have unclear function. In a recent study, three new nodulopeptins with molecular weight of 899, 901 and 917 were characterised from N. spumigena KAC 66. In the present study, N. spumigena KAC 66 was fractionated by reversed phase flash chromatography and their toxicity was determined by their lethality to Daphnia pulex and D. magna along with inhibition of protein phosphatase 1 assay (PP1). All fractions showed lethality to Daphnids and inhibitory activity against PP1, the toxicity was due to additional compounds as NOD and nodulopeptin 901 were only detected in 7 fractions. Pure NOD was lethal to D. pulex and D. magna LC50= 8.4 μg/mL and 5.0 μg/mL, respectively. The newly characterised nodulopeptin 901 was also tested against D. magna (LC50=>100 μg/mL). NOD and nodulopeptin 901 inhibited PP1 with IC50 0.038 μg/mL and 25 μg/mL, respectively. In common with many studies, the maximum amount of NOD was retained within the cells during the seven week growth experiment. In contrast, as much as ~50% of nodulopeptin 901 was detected in the growth media throughout the duration of experiments. To gain further insight on the effects of environmental stress on growth and production of bioactive metabolites in N. spumigena KAC 66, a range of parameters were investigated which included; temperature, salinity, nitrate and phosphorus. In the present study it was investigated that extreme growth conditions have a considerable effect on biomass and toxin levels by N. spumigena KAC 66. The light intensity ranged from 17.35-17.47 μmol/s/m2, 22°C and 11-20 ‰ of salinity were the optimal growth conditions to obtain maximum biomasses, intra and extracellular peptide contents. At 6.5 mg/L nitrate the maximum growth, as indicated by Chl-a and maximum concentrations of intracellular NOD and nodulopeptin 901 were detected found in week 5 and 4, respectively. Temperature had the greatest effect on peptide production. Whilst growth was similar at 22°C, 25°C and 30°C, increase in temperature had a profound effect on NOD production in that an increase from 22°C to 25°C resulted in a 50% decrease in intracellular NOD levels. At 30°C little or no NOD was detected. In contrast, whilst concentrations of nodulopeptin 901 decreased with increasing temperature, they were still detected at consistent levels suggesting they play an important role. The results from phosphate experiment showed Chl-a, cell biomass and peptide production did not show clear dependency on availability of PO-3 4. This is the first study to evaluate the effects of selected environmental parameters on NOD/nodulopeptin 901 production which ultimately may be helpful to explain the distribution, control of natural blooms and toxin levels of N. spumigena in the Baltic Sea and as well as laboratory based experiments. In an attempt further exploit cyanobacterial diversity, 20 strains were isolated from the Dian Lake and 6 from the Dead Sea. The UPLC-PDA-MS analysis of isolates, Microcystis spp. from Dian Lake, China indicated the presence of several peptides namely MC-LR, cyanopeptolin A and aerucyclamides A-D. These new isolates will be examined for biological activity and chemical characterisation in future studies.

Ortmann, Regina, e Erich Pummerer. "Formula Apportionment or Separate Accounting? Tax-Induced Distortions of Multinationals' Location Investment Decisions". WU Vienna University of Economics and Business, Universität Wien, 2015. http://epub.wu.ac.at/4703/1/SSRN%2Did2688090.pdf.

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We examine which tax allocation system leads to more severe distortions with respect to locational investment decisions. We consider separate accounting (SA) and formula apportionment (FA). The effects of both systems have been hotly debated in Europe in the past years. The reason is that the EU Member States are striving to implement a common European tax system that would lead to a switch from SA to FA. While existing studies focus primarily on the impact of taxes on locational decisions under either SA or FA, the main innovation of this paper is that it compares both systems with regard to the level of distortions they induce. We compare the optimal pre-tax investment decision with the optimal after-tax investment decision and infer from the difference in the allocation of investment funds which tax allocation system causes more severe distortions. We assume that the multinational group (MNG) has comprehensive book income shifting opportunities under SA. We find that the investment incentives under SA are opposed to those under FA for a profitable investment project. Whereas under SA as much as possible should be invested in a high-tax country, under FA as much as possible should be invested in a low-tax country. The distortions of locational investment decisions tend to be more severe under SA than under FA if a greater share of investment funds is to be invested in a low-tax country from a pre-tax perspective and the investment is profitable. Vice versa, locational decisions may be more distorted under FA if the optimal pre-tax investment decision requires investing a major share of funds in the high-tax country. In contrast to the often stated insensitivity of FA towards income shifting, we find the introduction of a tax allocation system based on FA in Europe could lead to a severe shift of economic substance to low-tax countries. The results of this paper are of particular interest for European policy makers and MNGs as our findings may induce European MNGs to reassess their recent locational investment decisions in the face of a potential future change in the applied tax allocation system. (authors' abstract)
Series: WU International Taxation Research Paper Series

Ortmann, Regina. "Uncertainty in Weighting Formulary Apportionment Factors and its Impact on After-Tax Income of Multinational Groups". WU Vienna University of Economics and Business, Universität Wien, 2015. http://epub.wu.ac.at/4609/1/SSRN%2Did2521386.pdf.

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Formulary apportionment is an intensively debated mechanism for allocating tax base within multinational groups. Systems under which the formula is identical in all jurisdictions and systems under which jurisdictions can determine the weights on the formula factors individually can be observed. The latter systems produce uncertainty about the overall tax-liable share of the future group tax base. Counter-intuitively, I identify scenarios under which increased uncertainty leads to higher expected future group income. My results provide helpful insights for firms and policy makers debating the specific design of a formulary apportionment system. (author's abstract)
Series: WU International Taxation Research Paper Series

Wittlich, Marc [Verfasser]. "Strukturelle Untersuchungen an membranassoziierten Proteinen : NMR-Strukturen des HIV-1 Virus-Protein U (39-81) und des humanen CD4 (372-433) / vorgelegt von Marc Wittlich". 2008. http://d-nb.info/99076513X/34.

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Libri sul tema "616.831 1":

Ratujmy Alfa! Katowice, Poland: Debit, 2022.

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W blasku nocy. Jaguar, 2018.

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Edytor tekstów Word. Itstart, 2022.

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Майстер корабля. Знання, 2020.

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Marques, Marcia Alessandra Arantes, a cura di. Pesquisa em Engenharia: Ciência e Aplicação. Bookerfield Editora, 2022. http://dx.doi.org/10.53268/bkf22040200.

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Neste livro são apresentados resultados de trabalhos científicos aplicados à grande área de Engenharia. De abordagem objetiva, a obra se mostra de grande relevância para graduandos, alunos de pós-graduação, docentes e profissionais. Os capítulos estão agrupados em duas seções: i) materiais; ii) águas continentais e oceânicas. Pelo capítulo um é apresentado o desenvolvimento de uma metodologia para obter-se reprodutibilidade da área superficial de um eletrodo de estanho durante o estudo do crescimento de óxidos de estanho. A reprodutibilidade da área superficial pode ser comprovada pela reprodutibilidade das densidades de carga anódicas dos voltamogramas anódicos a 50 mVs-1 posteriores a cada tratamento. Por meio do capítulo dois é analisada a substituição de parte do carvão mineral, utilizado em siderúrgicas, por biomassa. Entre os grandes desafios do setor estão a produção de aço a preços competitivos e a substituição de parte do carvão mineral utilizado por biomassa. A biomassa é considera neutra em emissões de CO2, devido a captura do mesmo durante o processo de fotossíntese, o que a torna atraente para seu uso nos processos siderúrgicos. Além disso, o seu uso pode gerar redução de custos, principalmente se for considerado os rejeitos do agronegócio que não possuem um alto valor agregado. Neste contexto, por este capítulo serão mostradas algumas possíveis utilizações de biomassa nos processos siderúrgicos através de estudos que vem sendo realizado no tema e aplicações na indústria. Será possível notar que o uso de biomassa é uma alternativa viável a curto prazo para atender as crescentes restrições ambientais atuais. Através do capítulo três é analisado o crescimento voltamétrico de óxido de estanho em solução tampão fosfato, pH 8,7. Medidas elipsométricas ex-situ foram realizadas para determinar a espessura dos óxidos crescidos. A partir desses resultados, o volume do filme por unidade de carga, Vf, foi calculado para diferentes densidades de carga. As medidas elipsométricas mostram que filmes de óxido de estanho crescidos a 2 mVs-1 são menos densos para valores de espessura 3,37 nm, tendo Vf próximo a 1,70 x 10-4 cm3C-1. Para valores mais altos de espessura (11,0 – 12,4 nm) os filmes se tornam mais densos tendo Vf próximo a 0,5 x 10-4 cm3C-1. No caso de 100 mVs-1 os filmes apresentam o mesmo comportamento, tendo Vf próximo de 3,74 x 10-4 cm3.C-1 para espessura de 4,56 nm e Vf próximo de 1,32 x 10-4 cm3.C-1 para espessura de 7,42 nm. Imagens de Microscopia de Força Atômica mostraram que a morfologia muda e a rugosidade dos filmes aumenta com o aumento da espessura e do potencial final da voltametria. O capítulo quatro trata do Nitreto cúbico de boro (cBN), material imprescindível para usinagem com alta precisão e alta velocidade de APRESENTAÇÃO materiais ferrosos como aço. O cBN é recomendado para trabalhos sob condições severas, tais como corte intermitente, em que dureza deve estar associada com tenacidade para evitar a quebra. Na síntese do cBN, são aplicados, basicamente, dois tipos de catalisadores: nitreto de magnésio e magnésio. Cada qual oferece diferentes possibilidades, tais como maiores valores de profundidade de corte ou menor nível de rugosidade superficial. Este capítulo contribui para uma melhor compreensão da manipulação dos parâmetros aplicados no regime de síntese deste elemento e, favorecendo o desenvolvimento da tecnologia de sua produção. Por meio do capítulo cinco é avaliada a aplicação de separação magnética de alta intensidade no beneficiamento de itabiritos pobres. Na rota de processo avaliada (separação magnética + flotação), a etapa de separação magnética executa a função de pré-concentração e deslamagem. O teor de SiO2 no concentrado foi de 1,46% (menor que o teor objetivo de 2,00%). As recuperações mássica e metalúrgica obtidas com a rota separação magnética + flotação foram maiores em termos absolutos 3,3% e 4,4%, respectivamente. Através do capítulo seis é realizada a otimização de injeção de poliamida PA66 com 50% GF usando o método Taguchi. O estudo se justifica pela necessidade crescente de materiais mais leves e de maior produtividade em substituição às ligas metálicas, o que demanda o constante desenvolvimento de compósitos poliméricos e eficazes processos de fabricação. Como resposta do estudo, mediu-se a resistência máxima de tração (RTmáx), numa poliamida 66 com carga de 50% de fibra de vidro, Grivory GV-5H®. Fez-se uso da metodologia ANOVA para indentificar-se os fatores de maior significância para o processo. A melhor resistência máxima de tração obtida de 242,6 N/m2, mostrou-se como uma opção na substituição à aplicações de ligas metálicas de alumínio. A melhor resultado se obteve com a temperatura de processamento em 270°C, o fluxo volumétrico de 83 cm³/s, a pressão de recalque de 300 bar, a contrapressão de 10 bar, velocidade da rosca de 50 min-1 e o tempo de recalque com valor de 5 s. As porcentagens de contribuição encontradas foram pressão de recalque com contribuição de 61%, seguido da temperatura de processamento, com contribuição de 17% e em terceiro, o fluxo volumétrico com contribuição de 12%. A instalação de grandes equipamentos submarinos em águas profundas apresenta uma série de desafios. O capítulo sete trata da análise de estabilidade hidrodinâmica de Manifolds submarinos durante a instalação pelo método pendular. O presente capítulo racionaliza tal método e, além disso, considera sistemas para evitar o capotamento, durante um momento crítico do método que é o início da descida, apresentando uma modelagem matemática fenomenológica a partir de casos similares. A etapa de validação foi realizada pela análise comparativa entre a modelagem proposta e resultados de testes experimentais realizados com modelos físicos. Com a confirmação da aderência dos resultados numéricos com os experimentos, esta abordagem se confirma como uma ferramenta de engenharia para dimensionamento dos equipamentos submarinos instalados pelo Método Pendular para que sejam direcionalmente estáveis. Por meio do capítulo oito são apresentados os resultados da simulação da distribuição espacial das ondas geradas pela ação de ventos severos sobre o reservatório da barragem de Salto Caxias, no rio Iguaçu, estado do Paraná. Os ventos severos foram estimados através da análise de frequência regional para várias estações anemométricas do Instituto Meteorológico do Paraná (SIMEPAR) para o período de 1998 a 2005. As alturas de ondas foram estimadas pelo método paramétrico SMB, que usa como dados de entrada o fetch e a velocidade do vento. O método SMB foi aplicado pelo modelo computacional ONDACAD. Os testes estatísticos indicaram que a distribuição de Wakeby foi a mais robusta para as séries curtas de ventos horários máximos anuais, produzindo estimativas de ventos severos que variaram entre 25,7 ms-1 (tempo de retorno de Tr=10 anos) a 50,9 ms-1 (Tr=100 anos). O estudo presta grande contribuição à compreensão da quantificação das alturas de ondas geradas por ventos severos neste importante reservatório do estado do Paraná. Pelo capítulo nove é apresentada uma análise comparativa bidimensional entre alturas de ondas resultantes da aplicação dos modelos paramétricos MARQUES e JONSWAP ao reservatório da Usina Hidrelétrica de Itaipu Binacional, localizado no Rio Paraná entre o Brasil e o Paraguai. Os campos de vento uniforme relacionados a períodos de recorrência de 10, 20, 50 e 100 anos foram obtidos pelos registros realizados pelo Sistema Meteorológico do Paraná (SIMEPAR). Através da utilização do modelo ONDACAD foram determinados os campos de fetch e a transformação em campos de ondas pela utilização dos modelos paramétricos MARQUES e JONSWAP. Ao proceder a análise constatou-se que, ao majorar os resultados do modelo JONSWAP em 78% chega-se aos resultados bidimensionais gerados pelo modelo Marques. Esta condição foi verificada para situações de ventos extremos, ou seja, superiores a 20ms-1 e corpos hídricos que possuem fetch máximo da ordem de 10 quilômetros. O estudo contribui para a compreensão da distribuição das magnitudes das alturas de ondas neste reservatório de grande importância no âmbito da América do Sul, de grande utilidade para estudos relacionados, por exemplo, a erosões marginais, ecossistemas aquáticos continentais, psicultura por tanques-rede, quantificação de gases de efeito estufa devido à ressuspensão de sedimentos devido a propagação de ondas.

Marques, Marcia Alessandra Arantes, a cura di. Pesquisa em Engenharia: Ciência e Aplicação. Bookerfield Editora, 2022. http://dx.doi.org/10.53268/bkf22040200.

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Capitoli di libri sul tema "616.831 1":

Xiao, Jun, e Maofei Geng. "Analysis and Treatment of Gas Pulsation in the Pipeline of a Hydrogen Diaphragm Compressor". In Proceedings of the 10th Hydrogen Technology Convention, Volume 1, 1–14. Singapore: Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-8631-6_1.

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AbstractBased on the plane wave theory and the transfer matrix method, the modeling, calculation and analysis of gas pulsation in a complex pipeline system of a hydrogen diaphragm compressor were carried out. The calculations show that the gas pulsations of the intake and exhaust pipelines of the cylinder gradually attenuate along the pipeline upstream and downstream, and the gas pulsation of the exhaust pipeline of the second stage cylinder is larger. The gas pulsations of the exhaust pipelines of the first and second stage cylinders are significantly higher than the limit values of API 618. From the perspective of pulsation control, an attempt was made to add orifice plates at appropriate positions of the pipeline to reduce the pulsation amplitude. The trial calculations show that the added orifice plate can effectively reduce the maximum gas pulsation of the pipeline, and can provide a useful reference for the treatment of gas pulsation.

Лук'яник, І. В. "Проходження комет через перигелій у 2022 році". In Одеський астрономічний календар 2022, 98–101. Одеса, Україна: Odesa I. I. Mechnikov National University, 2021. http://dx.doi.org/10.18524/978-617-689-514-5.2022.23.98-101.

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У 2022 році очікується проходження через перигелій 83 комет: 75 короткоперіодичних (2 – загублених, 16 – лише вдруге проходитимуть перигелій) та лише 8 довгоперіодичних. Цей рік, на відміну від трьох попередніх, обіцяє бути роком надій на добрий улов для спостерігачів комет. Очікується одинадцять комет, блиск яких у максимумі перевищить 10 m. У таблиці 1 наведено комети, проходження яких через перигелій очікується у 2022 році. У таблиці 2 наведено комети, очікуваний блиск яких у 2022 році буде більшим за 10 m.

Blouin, Cécile, e Cristina Zamora Gómez. "Institutional and Social Xenophobia Towards Venezuelan Migrants in the Context of a Racialized Country: The Case of Peru". In IMISCOE Research Series, 169–89. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-11061-0_8.

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AbstractAlthough there is a growing academic interest in xenophobia in South America (Chan & Strabucchi, Asian Ethnicity 22(2):374–394, 2020; Tijoux-Merino, Convergencia: Revista de Ciencias Sociales 20(61):83–104, 2013; Guizardi & Mardones, Estudios Fronterizos 21:1–24, 2020), research is incipient on Peru due, in part, to the recent changes in migration trends. Moreover, in the case of Peru, scholars have not explored how xenophobia and racism intersect and connect. Addressing this gap, this chapter examines xenophobia in Peru against the Venezuelan community from an institutional and social perspective, addressing how both perspectives are relational and self-sustaining in a context of racialization. We use a mixed methodology that combines literature and political-normative analysis with quantitative data analysis. We examine how the institutional xenophobia against Venezuelan migration in the country, expressed through legislation as well as informal and formal practices of exclusion, have portrayed migrants as invaders. We also argue that the structural and complex racialization that operates in the country is also nourished by a special hatred against the foreigner who threatens the fragile sense of nationhood in Peru. Thus, we observe the emergence of a feeling of Venezuelanphobia as a hatred towards everything that has to do with ‘the Venezuelan.’

Friedman, Richard D. "Witnesses: competence, impeachment, and support (FRE 801(d)(1)(A), (B), 603, 605, 606, 610, 611, 613, 701)". In Advanced Introduction to Evidence, 115–32. Edward Elgar Publishing, 2024. http://dx.doi.org/10.4337/9781802201819.ch15.

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Atkins, Peter, Julio de Paula e Ronald Friedman. "The uncertainty principle". In Physical Chemistry: Quanta, Matter, and Change. Oxford University Press, 2013. http://dx.doi.org/10.1093/hesc/9780199609819.003.0011.

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Contents Complementarity 58 Brief illustration 8.1: Uncertainty in position and momentum 1 59 The Heisenberg uncertainty principle 59 Example 8.1: Calculating the uncertainty in linear momentum 60 Brief illustration 8.2: Uncertainty in position and momentum 2 60 Commutation and complementarity 61 Example...

Wapakabulo Thomas, Josephine. "Summary and Recommendations". In Advances in IT Standards and Standardization Research, 258–70. IGI Global, 2010. http://dx.doi.org/10.4018/978-1-60566-832-1.ch010.

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The benefits of standardization are realised through the effective adoption, implementation and use of standards. Nonetheless, there are a cross-section of factors that impact the adoption and diffusion of standards. Indeed, within the IT standards research community, there is a research area devoted to looking at IT standards adoption. However, there are currently a limited number of peer-reviewed, empirical studies that look at the adoption of IT standards. One particular set of IT standards where this is true is ISO data-exchange standards, particularly those produced by the ISO subcommittee ISO/TC184/SC4, and to date there are only two known studies that have looked at the adoption of the 614 standards published by the SC4 subcommittee.

Rich, Peter, e Samuel Frank Browning. "Using Dr. Scratch as a Formative Feedback Tool to Assess Computational Thinking". In Research Anthology on Computational Thinking, Programming, and Robotics in the Classroom, 550–72. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-2411-7.ch026.

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This study investigated if using Dr. Scratch as a formative feedback tool would accelerate students' Computational Thinking (CT). Forty-one 4th-6th grade students participated in a 1-hour/week Scratch workshop for nine weeks. We measured pre- and posttest results of the computational thinking test (CTt) between control (n = 18) and treatment groups (n = 23) using three methods: propensity score matching (treatment = .575; control = .607; p = .696), information maximum likelihood technique (treatment effect = -.09; p = .006), and multiple linear regression. Both groups demonstrated significantly increased posttest scores over their pretest (treatment = +8.31%; control = +5.43%), showing that learning to code can increase computational thinking over a 2-month period. In this chapter, we discuss the implications of using Dr. Scratch as a formative feedback tool the possibilities of further research on the use of automatic feedback tools in teaching elementary computational thinking.

Rich, Peter, e Samuel Frank Browning. "Using Dr. Scratch as a Formative Feedback Tool to Assess Computational Thinking". In Advances in Educational Technologies and Instructional Design, 220–42. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-1479-5.ch012.

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Gee, Austin. "Britain Since 1914". In Annual Bibliography Of British And Irish History, 178–222. Oxford University PressOxford, 1998. http://dx.doi.org/10.1093/oso/9780198152941.003.0009.

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Abstract Brothers, Barbara; Gergits, Julia M. (eds.) British travel writers, 1910-1939. (Detroit (WA): Gale, 1998), xxi, 465p. (Dictionary of literary biography, 195.) Wurm, Clemens August. ‘Britain and European integration, 1945-63’, Contemporary European History 7 (1998), 249-61. Wylie, Neville. ‘Marcel Pilet-Golaz, David Kelly and Anglo-Swiss relations in 1940’, Diplomacy and Statecraft 8:1 (1997), 49. Yearwood, Peter J. ‘ “Real securities against new wars”: official British thinking and the origins of the League of Nations, 1914-19’, Diplomacy and Statecraft 9:3 (1998), 83-109.

Araújo, Vanessa De Fátima Carneiro De, Juce Silva de Souza, Karolayne Janilda Lima de Oliveira, Michele Menezes de Barros, Wanderson Cunha Pereira e Thaisa Pegoraro Comassetto. "TOXICIDADE DE PARACETAMOL EM SEMENTES DE ALFACE (LACTUCA SATIVA)". In Conservação e Biodiversidade Amazônica: potencialidade e incertezas - Volume 2, 138–45. Editora Científica Digital, 2022. http://dx.doi.org/10.37885/230212235.

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Este trabalho teve como objetivo avaliar a toxicidade do fármaco paracetamol por meio de bioensaio em sementes de alface. O experimento, realizado em placas de petri, foi instalado em laboratório, com delineamento inteiramente ao acaso, com 5 tratamentos (água destilada = 0 mg L-1; 2,7 mg L-1; 5,0 mg L-1; 9,3 mg L-1 e 15 mg L-1) e 4 repetições. As parcelas experimentais, placas de petri, foram compostas por 10 sementes de alface, cujas variáveis analisadas foram o número de sementes germinadas, crescimento da radícula e do hipocótilo (mm) de cada semente, e peso (mg) das 10 sementes. Estas foram submetidas à Análise de Variância (α = 0,05) e ao Teste de Tukey (α = 0,05) para comparações das médias quando necessário. As concentrações de paracetamol de 2,7 mg L-1 e 15 mg L-1 causaram redução no crescimento da radícula em 30% e 82%, respectivamente. No crescimento do hipocótilo, tais concentrações afetaram em 53% e 83%, respectivamente. Já no peso tais concentrações afetaram em 45% e 66%, respectivamente. Nas condições em que esse experimento foi realizado, o fármaco paracetamol foi tóxico para o desenvolvimento das plântulas de alface.

Atti di convegni sul tema "616.831 1":

Zacharski, L., V. Memoli e S. Rousseau. "THROMBIN-SPECIFIC SITESOF FIBRINOGEN IN SMALL CELL CARCINOMA OF THE LUNG". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643670.

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Thrombin-generated cleavage sites of human fibrinogen have been identified within the connective tissue stroma adjacent to viable tumor cells in fresh frozen sections of small cell carcinomaof the lung (SCCL) by means of immunohistochemical techniques using mouse monoclonal antibodies (designated alpha and beta) to the N-terminal peptides of the fibrinogen alpha and beta chains(provided by G. Matsueda and E. Haber).Specific connective tissue staining with antibody alpha was diffuse while staining with antibody beta was linear and focal. These results indicate thatthrombin is generated in situ in this tumor type. Previous demonstration of an initiator of coagulation together with coagulation factor intermediates associated with viable SCCL tumor cellsin situ(Cancer Res. 43:3963, 1983; Blood 66 (Suppl.1):329, 1985) is consistent with the hypothesis that the tumorcells themselves are responsible for the local thrombin generation. Because favorable effects of anticoagulant therapy with warfarin in SCCL have been demonstrated previouslyin two randomized clinical trials (J.A.M.A. 145:831, 1981; Proc. Am.Soc. Clin. Oncol. 4:191,1985), we postulate that local tumor cell-induced thrombin formation may contributeto self-regulated progression of SCCL through formation of a supportive, fibrin-rich connective tissue stroma (N. Engl. J. Med. 315:1650, 1986) and/or stimulation of cell proliferation (e.g. E.M.B.0. J. 4: 2927,1985; Proc. Natl. Acad. Sci. U.S.A. 83:976, 1986). These results suggest novel treatment strategies for this particular tumor type and justify efforts to identify other tumortypes in which similarmechanisms exist.

Rao, Nikhil M., e Cengiz Camci. "Axial Turbine Tip Desensitization by Injection From a Tip Trench: Part 2 — Leakage Flow Sensitivity to Injection Location". In ASME Turbo Expo 2004: Power for Land, Sea, and Air. ASMEDC, 2004. http://dx.doi.org/10.1115/gt2004-53258.

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In Part 1 of this paper it was shown that discrete jets issuing from a tip platform trench were successful in reducing the total pressure deficit due to tip leakage flow. The specific tip cooling system used in Part 1 had all four injection locations active. This paper examines the effect of the individual location of the injection hole on the tip leakage flow. The investigation was carried out in a large-scale rotating rig. Total pressure downstream of the rotor exit was measured using a Kulite sensor. The measurements were phase-locked and ensemble averaged over 200 rotor revolutions. The injection holes are located at 61%, 71%, 81%, and 91% blade axial chord, in the tip trench of a single blade with a clearance of 1.40% blade height. Individual injection at 61% and 71% chord reduced the leakage vortex size. Coolant injection at 81% chord was the most successful in reducing the total pressure deficit in the leakage vortex. Injection from 91% chord had no effect on the leakage vortex. Injection from combinations of holes had greater effect in reducing the leakage vortex size and the total pressure deficit associated with the vortex. It can be concluded that the individual jets most likely turn the leakage flow towards the trailing edge. Most of the leakage flow that is responsible for the greatest total pressure deficit occurs around 80% chord.

Jansone, Baiba, Edgars Dubrovskis e Linards Sisenis. "INFLUENCE OF TREE SPECIES MIXTURE TO REDUCE WIND DAMAGES IN BIRCH STANDS". In GEOLINKS International Conference. SAIMA Consult Ltd, 2020. http://dx.doi.org/10.32008/geolinks2020/b2/v2/07.

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Climate change is linked to increase in frequency and/or severity of different damages in forest stands. Birch (Betula spp.) stands can be significantly affected by wind and snow (freezing rain). Aim of our study was to assess, if admixture of other tree species reduces the proportion of damaged trees in birch stands. Data from total of 836 sample plots (size 500m2) in birch stands at the age of up to 81 year were analysed. Among the mixed sands (MS) and pure stands (PS >80% of single tree species), the mean proportion (± confidence interval) of damage was assessed from the total number (TN) and basal area (BA) of overstory (first layer) trees. MS were further assessed in two groups – one or more species in admixture (MS+1 and MS+2). The proportion of mixed birch stands was increasing with age: from average of 21% at the age of up to 20 years to 64% at the age of 61-70 years, most likely do to difference in historical management. In period between the 1950th and 1990th, birch was considered as undesirable species and the older stands formed mainly due to low survival of coniferous trees and natural ingrowth of birch, whereas starting from the 1990th birch was more widely recognized and used as target species. Proportion of undamaged birch trees (both, when assessed as TN or BA) was not significantly different between MS and PS. Also presence of second layer trees did not affect the proportion of damaged overstory trees significantly. There were significant differences among the groups of mixed stands: more wind or snow damaged trees were found in certain age groups in stands with more than one admixture species present. Creating a mixed birch stands in comparison to pure stands of the same tree species may not result in lower frequency of damaged trees, thus this approach cannot be automatically recommended as a tool for adaptation to climate change

Tengker, Soenandar Milian, Marlina Karundeng e Jessica Indah Samuri. "Metal Analysis of Pb, Fe, Cd with Activated Carbon Material in Tondano Watershed, East Kombos Area, Manado City". In Unima International Conference on Science and Technology 2022. Switzerland: Trans Tech Publications Ltd, 2023. http://dx.doi.org/10.4028/p-5ghdcj.

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This study aimed to determine the characteristics of activated charcoal from mangroves resulting from pyrolysis and activation with 3M KCl using Fourier Transform Infra-Red (FTIR), X-Ray Diffraction (XRD) and ash content analysis and to determine the ratio of Pb, Fe and Cd metal content in river water before and after filtered with activated charcoal. The results of the FTIR test for charcoal from mangroves resulting from pyrolysis and activation with KCl showed the presence of O-H, C=C, C-H, C-N and C-Cl groups as additional groups that appeared after the activation process. The results of XRD analysis show that the lattice parameter (α) can be calculated, namely in pyrolysis mangrove charcoal = 5.79 and charcoal from pyrolysis and activation mangrove wood = 5.88. The results show that there is a change in the distance between the crystal planes after activation, with the known value of, the results of d-spacing 3 strong peaks are 3.39 , 2.94 and 5.88 . The results of the analysis of the ash content are 15.4% and exceed the maximum percentage that has been determined, because there are still impurities attached to the carbon surface. The results of the analysis using Atomic Absorbtion Spectrophotometry (AAS) showed that there were differences in the levels of Pb, Fe and Cd in river water before and after being filtered with activated charcoal. There was a decrease in Pb levels from points 1,2 and 3 as much as 73%, 49% and 55.23%. Meanwhile, Fe metal decreased from points 1, 2 and 3 as much as 58%, 66% and 81%. And on Cd there was a decrease of 44%, 61% and 92%. From these percentage results, activated charcoal from mangroves can be said to be effective because it can absorb metals in river water. Pb metal in river water in East Kombos Manado City has passed the concentration specified in Government Regulation of the Republic of Indonesia No. 22 of 2021, Class II Water Quality Standards.

Giannessi, D., R. De Caterina, G. Lazzerini, R. Sicari e P. Gazzetti. "RELATIVE SENSITIVITY OF CARDIAC PROSTACYCLIN AND THROMBOXANE TO INHIBITION BY NON-STEROIDAL ANTIINFLAMMATORY DRUGS IN THE RAT HEART". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643390.

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We have previously shown that the isolated perfused rat Langendorff heart is able to synthesize detectable amounts of thromboxane (TX) A2, as well as prostacyclin (PGI2). Eicosanoid production in this system is increased during post-ischemic reperfusion, reflecting greater availability of substrate and net increase of synthesis. We assessed relative sensitivity of cyclooxygenases synthesizing TX and prostacyclin (probably located in different cell types) to aspirin (0.1, 0.5, 1 g/1), ibuprofen (1, 10, 80, 160, 320 mg/1) and diclofenac (0.01, 0.1, 0.5, 2.5, 5, 10, 25 mg/1), by radioimmunoassays of TXB2 and 6-keto-PGFα in the perfusate. Sixty Wistar male rat hearts were perfused with buffer containing control vehicle or drugs for 30 min, followed by 5 min clamping of the perfusion line and subsequent post-ischemic reperfusion. Baseline production was (mean±SD, pg/min/g wet weight) 754±261 and 143±66 for PGI2 and TXA2, respectively. Peak post-ischemic production was 7628±2673 and 1036±135, respectively. At doses of aspirin, ibuprofen and diclofenac (100, 10 and 2.5 mg/1, respectively) which were equally effective on prostacyclin production (mean % inhibition: 68, 67 and 72 for basal production and 90, 86 and 85 for peak post-ischemic production, respectively), % inhibition of TX production was consistently less, but also similar for the three drugs: 55, 58 and 56 for basal production and 78, 81 and 76 for peak post-ischemic production, for aspirin, ibuprofen and diclofenac, respectively; difference between inhibition of prostacyclin and TX: P < .01, difference for subsets among different drugs: N.S.). TX production was, on the contrary, selectively inhibited by the TX-synthase inhibitor 0KY 046 (by 79 and 92% at 0.1 mg/1, versus a complete sparing of prostacyclin production). The lesser sensitivity of cardiac (vascular?) TX versus prostacyclin to non-steroidal antiinflammatory drugs (NSAIDs) inhibition and the similar degree of inhibition by various NSAIDs, differing in structure and diffusing capacity, suggest heterogeneity among cyclooxygenases present in the system and different intrinsic sensitivity of TX- from prostacyclin-producing cyclooxygenases.

Овсянникова, А. К., М. В. Дудина, Р. Б. Галенок e О. Д. Рымар. "КЛИНИЧЕСКИЕ ОСОБЕННОСТИ ТЕЧЕНИЯ РАЗЛИЧНЫХ ТИПОВ САХАРНОГО ДИАБЕТА У ЛИЦ МОЛОДОГО ВОЗРАСТА". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-84.

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Возрастная группа до 45 лет наиболее сложна для определения типа сахарного диабета (СД), так как в ней может встречаться диабет 1 типа (СД1), 2 типа (СД2), MODY и LADA. Целью исследования: определить клинические маркеры для проведения дифференциальной диагностики типов СД у молодых пациентов. МАТЕРИАЛЫ И МЕТОДЫ: включено 202 пациента, которые наблюдаются в НИИТПМ-филиал ИЦиГ СО РАН, с началом диабета в возрасте от 18 до 45 лет: 1 группа – 77 пациентов с MODY, 2 – 83 с СД 2, 3 – 14 с СД 1, 4 – 28 с LADA. Группы сопоставимы по полу, возрасту. Пациенты сравнивались по отягощенной наследственности по СД, особенностям дебюта заболевания, коморбидным патологиям, исходным ан- тропометрическим показателям. РЕЗУЛЬТАТЫ: при MODY чаще, чем при СД2, при СД1 и LADA определялась отягощенная наследствен- ность по СД2 (95 и 79 %, р=0,005, 95 и 29 %, р<0,001, 95 и 64 % р=0,035), чаще родственники заболевали СД до 45 лет (70 и 29 %, р<0,001, 70 и 14 %, р<0,001) и более, чем в 3 поколениях (65 и 28 %, р<0,001, 65 и 7 %, р<0,001, 65 и 8 %, р<0,001, 65 и 15 %, р<0,001). При СД 2 чаще определялось ожирение, чем при MODY (34 и 4 %, р<0,001), заболевания желудочно-кишечного тракта (25 и 6 %, р=0,001) и артериальная гиперто- ния (14 и 5 %, р=0,044). При СД1 чаще, чем при MODY и при СД2, были симптомы при диагностировании СД (93 и 23%, р<0,001, 93 и 26 %, р<0,001), снижение веса (50 и 3 %, р<0,001, 50 и 0 %, р<0,001), кетоацидоз (64 и 1 %, р<0,001, 64 и 1 %, р<0,001). При СД1 чаще чем при LADA был кетоацидоз (64 и 15 %, р=0,013). При LADA, чаще при СД2 были симптомы СД (61 и 26%, р=0,016) и снижение веса (15 и 0%, р=0,017) и реже за- болевания желудочно-кишечного тракта (0 и 25 %, р=0,031). При LADA чаще, чем при MODY были симптомы СД (61 и 23 %, р=0,009), ожирение (31 и 4 %, р=0,008) и патология щитовидной железы (31 и 9%, р = 0,040). ВЫВОДЫ: 1. Основные клинические характеристики для проведения дифференциальной диагностики типа СД: отягощенная наследственность по СД, вес пациентов; наличие клинических симптомов гипергликемии, кетоацидоза в дебюте. 2. При диагностировании СД 2 у лиц молодого возраста необходимо проводить скрининг на наличие артериальной гипертонии, заболеваний желудочно-кишечного тракта, ожирения, при LADA - на за- болевания щитовидной железы. Тезисы написаны в рамках гранта Президента РФ для государственной поддержки молодых российских ученых - докторов наук МД-3017.2022.3.

Салимханов, Р. Х., А. К. Еремкина, Е. В. Ковалева, А. Р. Елфимова, А. М. Горбачева, О. К. Викулова, Г. А. Мельниченко, И. И. Дедов e Н. Г. Мокрышева. "КЛИНИЧЕСКИЕ ХАРАКТЕРИСТИКИ ПЕРВИЧНОГО ГИПЕРПАРАТИРЕОЗА ПО ДАННЫМ ВСЕРОССИЙСКОГО РЕГИСТРА". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-41.

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ЦЕЛЬ: изучить основные эпидемиологические и клинические характеристики первичного гиперпара- тиреоза (ПГПТ) по данным всероссийского регистра. МАТЕРИАЛЫ И МЕТОДЫ: объектом исследования являются пациенты с ПГПТ, данные которых внесены в электронную информационно-аналитическую базу регистра (http://pgpt.clin-reg.ru/) с возможностью он- лайн-доступа на всей территории Российской Федерации (РФ). Анализ проводился 12.01.2023 г. по данным последнего визита пациента, внесенного в регистр, независимо от его давности. РЕЗУЛЬТАТЫ: общее количество пациентов составило 6003 чел. (женщины/мужчины 11,7/1) из 81 ре- гиона РФ. Активная фаза заболевания зарегистрирована у 61% пациентов (3681/6003). Среди них в 74% (2717/3681) случаев отмечена симптомная форма ПГПТ, бессимптомная - в 26% (964/3681). Сочетание костных и висцеральных осложнений заболевания выявлено в 37% (1017/2717), а изолированные вис- церальные и костные нарушения - в 20% (536/2717) и 32% (861/2717), соответственно. Пациенты с сим- птомной формой заболевания имеют значимо более высокие показатели ПТГ и кальция крови, а также суточной кальциурии по сравнению с лицами с бессимптомным течением – медиана ПТГ 131,0 [84,6; 218,0] vs 112,0 пг/мл [84,0; 157,0]; общего кальция 2,72 [2,60; 2,88] vs 2,66 ммоль/л [2,53; 2,77], альбумин-скоррек- тированного кальция 2,68 [2,57; 2,83] vs 2,61 ммоль/л [2,50; 2,71], ионизированного кальция 1,35 ммоль/л [1,26; 1,45] vs 1,30 ммоль/л [1,21; 1,38], суточной кальциурии 7,16 [4,64; 9,90] vs 6,79 [5,02; 9,48] (p<0,001, U-тест, поправка Бонферрони Р0=0,008). Обращает на себя внимание низкая частота расчета альбумин- скорректированного кальция крови (только у 23% (1406/6003) пациентов), несмотря на то, что имеется автоматический расчет данного показателя при внесении результатов общего кальция и альбумина. Хирургическое лечение ПГПТ проведено у 53% (3215/6003) пациентов, среди них аденома диагно- стирована в 84%, гиперплазия - в 9%, карцинома околощитовидных желез - в 4% случаев (90/3215), ати- пическая аденома - в 2% (53/3215). Ремиссия заболевания после хирургического лечения установлена у 55% (1758/3215) пациентов, рецидив – у 13%. Подозрение на наследственный характер ПГПТ имеют 13% пациентов (805/6003), из них генетическое подтверждение получено в 171 случаях (21%), с наличием герминальных мутаций в генах MEN1 у 107 пациентов, CDC73 – у 6 и RET – у 2 человек. ВЫВОДЫ: в РФ преобладает симптомная форма ПГПТ с выраженными нарушениями фосфорно-каль- циевого обмена. При этом в большинстве случаев заболевание обусловлено доброкачественными обра- зованиями ОЩЖ. По данным проведенного анализа альбумин-скорректированный кальций определялся только в 23% случаев, тогда как расчет данного показателя необходим для исключения ложных отклонений уровня кальция крови при изменении концентрации плазменных белков. Повышение выявляемости ПГПТ в РФ имеет приоритетное значение для улучшения качества оказания медицинской помощи пациентам с данной патологией.

Lorenz, R., M. Holweger, GE Vogel e M. Classen. "SUBSTITUTION THERAPY WITH ANTITHROMBIN III: CLINICAL EXPERIENCE WITH DECOMPENSATED LIVER CIRRHOSIS AND HEMORRHAGIC COMPLICATIONS". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643069.

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In patients with decompensated liver cirrhosis, the coagulation disorder requires therapy only when bleeding complications occur. As therapy involves the risk of triggering a consumption coagulopathy, the discussion here examines the beneficial effect of boosting the inhibitor Potential by supplementing the administration of fresh plasma with substitution of AT III concentrate. To investigate this question, we conducted a retrospective study on the clinical course in 19 patients with decompensated liver cirrhosis, hepatic encephalopathy and bleeding complications.The following treatment scheme was employed uniformly in all 19 cases: substitution of vitamin K 20 mg/d, heparin 100 - 300 U/h and fresh plaspna 2-4 bags/d. AT III concentrate (3 - 8 × 500 U/d Ky-bemin HS ) was administered additionally in group 1 (n=8), but was omitted in group 2 (n= 11). Both groups were statistically comparable with regard to initial laboratory findings (e.g. bilirubin, group 1: 11.7 ± 3.6 mg/dl; bilirubin, group 2: 10 ± 2.9 mg/dl) and encephalopathy Tcoma stages 1-2), with the exception of the two survivors in group - who had been in a precomatose stage (stages 0-1) and had bilirubin levels of 3 ± 1.5 mg/dl.A comparison oT both collectives shows a lethality of 62.5 % (n=5) for group 1, and of 81 % (n=9) for group 2. Clinically, the incidence of hemorrhagic complications in group 1 was 61 %, but 100 % in group 2, although laboratory analysis showed no differences in the parameters of systemic coagulation. As regards the other laboratory values, including the transaminases and blood count, there were only differences in the development of the bilirubin values which, in group 1, rose to -3 ± 4 mg/dl only during the terminal phase, but which, in group 2, began to rise continuously from the second day of treatment onwards 2nd reached values of 28 ± 8.6 mg/dl.It follows that, in patients with decompensated liver cirrhosis and bleeding complications, the administration of AT III concentrate (Ky-bernin HS ) as a supplement to conventional coagulation therapy, increases the survival rate and reduces the incidence of further bleeding. It is, however, not possible tc explain the cause of this effect from the analysis of the laboratory data for the systemic coagulation. Therefore, one may hypothesize that the effect is due to beneficial effect of AT III within microcirculation.

Sotelo, Melissa, Dylan Richards, Matthew Pearson e Protective Strategies Study Team. "Self-Reported Symptoms of Cannabis Use Disorder (SRSCUD): Psychometric Testing and Validation". In 2020 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2021. http://dx.doi.org/10.26828/cannabis.2021.01.000.16.

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Findings from national surveys demonstrate that cannabis use peaks in young adulthood and that the annual prevalence of marijuana use among young adults (34.0%) is the highest it has been in decades (Johnston et al., 2016). We developed a 13 item measure designed to characterize the 11 symptoms of CUD as described in the DSM 5 (APA, 2013). To evaluate the performance of this Self Reported Symptoms of Cannabis Use Disorder (SRSCUD) measure, we examined its associations with other measures of CUD symptoms, negative cannabis related consequences, and other known risk factors for CUD (i.e., coping motives). Colleges students (n =7000) recruited from 9 universities in 9 states throughout the U.S. Our analyses focus on past month cannabis users (n = 2077). We split our sample in half to conduct exploratory factor analysis (EFA,n = 1011) and confirmatory factor analysis (CFA, n = 1012). All items loaded saliently on a single factor of CUD symptoms in both EFA (.553 = λ = 805) and CFA models (.524 = λ = 830) (see Table 1). In our final model, we allowed correlated errors between the two indicators of tolerance (items 10 and 11) and the two indicators of withdrawal (items 12 and 13), and obtained acceptable model fit across most indices: CFI = .941, TLI = .927, RMSEA = .059, SRMR = .042. As shown in Table 2, the total score of the SRSCUD was strongly correlated with other CUD symptoms measures (.617 < r s < .697), demonstrating convergent validity. SRSCUD was moderately positively correlated with a well known risk factor for CUD (coping motives) and moderately negative correlated with a well known protective (cannabis protective behavioral strategies). We conducted receiver operator characteristic (ROC) curve analyses to identify well how our continuous measure of CUD symptoms could identify individuals who exceed the cutoffs for probable CUD on these other symptom measures. For the most well validated measure (CUDIT R), we had excellent sensitivity/specificity (mean score of 1.5 on SRSCUD) for predicting probable CUD. Although more research evaluating performance of the SRSCUD compared to a clinical diagnosis is needed, we have preliminary evidence for construct validity of this measure.

Jackson, C. W., N. K. Hutson, S. A. Steward e H. H. Edwards. "THE WISTAR-FURTH RAT: AN ANIMAL MODEL OF HEREDITARY MACRO THROMBOCYTOPENIA". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643925.

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The mechanisms which determine and regulate platelet size are unknown. By phase microscopy, we serendipitously observed that Wistar/Furth (W/F) rats had macrothrombocytopenia. In this study, we have characterized and compared platelets and megakaryocytes (MK) of W/F rats to those of Wistar (W), Long-Evans hooded (LE) and Sprague-Dawley (SD) rats. In addition, we have examined the mode of inheritance of this W/F rat platelet abnormality. Average platelet count of W/F rats was only 312 ± 57 x 103/mm3 compared to 1086 ± 68, 868 ± 91 and 926 ± 82 x 103/mm3 respectively for W, LE and SD rats. Mean platelet volume (MPV) of W/F rats (8.1 ± 1.4 fl) was twice that of W (4.0 ± 0.2 fl), LE (4.2 ± 0.3 f1) and SD (4.1 ± 0.2 f1) rats. However, average MK diameter and DNA content distribution of W/F rats were not significantly different than those of LE rats. Average MK concentration was somewhat lower (4.5 MK/high power field) in the W/F strain compared to that of LE rats (6.6 MK/HPF). Maze-like membrane formations were observed in W/F MK and platelets by electron microscopy. Reciprocal crosses of W/F and LE rats resulted in offspring with MPVs (4.2 fl) and platelet counts like those of LE rats, indicating that the macrothrombocytopenic trait is recessive in its inheritance. Reciprocal marrow transplants between the W/F and LE strains resulted in MPVs like those of the donor strain indicating that the macrothrombocytopenia is an intrinsic marrow abnormality of the W/F strain. Analysis of W/F platelets by two-dimensional polyacrylamide gel electrophoresis revealed two readily detectable differences from those of W and LE rats: (1) absence of a protein of MW of 41,000 and pi of 6.35 and (2) presence of a protein of MW of 35,000 and pi of 5.9. In summary, the W/F rat has a hereditary macrothrombocytopenia which is recessive in nature and not due to differences in MK size or DNA content. These results suggest that the macrothrombocytopenia of W/F rats results from formation of fewer platelets per MK, possibly due to a qualitative or quantitative defect in some component necessary for proper subdivision of megakaryocyte cytoplasm into platelets.

Rapporti di organizzazioni sul tema "616.831 1":

O'Neill, Francis, Kristofer Lasko e Elena Sava. Snow-covered region improvements to a support vector machine-based semi-automated land cover mapping decision support tool. Engineer Research and Development Center (U.S.), novembre 2022. http://dx.doi.org/10.21079/11681/45842.

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This work builds on the original semi-automated land cover mapping algorithm and quantifies improvements to class accuracy, analyzes the results, and conducts a more in-depth accuracy assessment in conjunction with test sites and the National Land Cover Database (NLCD). This algorithm uses support vector machines trained on data collected across the continental United States to generate a pre-trained model for inclusion into a decision support tool within ArcGIS Pro. Version 2 includes an additional snow cover class and accounts for snow cover effects within the other land cover classes. Overall accuracy across the continental United States for Version 2 is 75% on snow-covered pixels and 69% on snow-free pixels, versus 16% and 66% for Version 1. However, combining the “crop” and “low vegetation” classes improves these values to 86% for snow and 83% for snow-free, compared to 19% and 83% for Version 1. This merging is justified by their spectral similarity, the difference between crop and low vegetation falling closer to land use than land cover. The Version 2 tool is built into a Python-based ArcGIS toolbox, allowing users to leverage the pre-trained model—along with image splitting and parallel processing techniques—for their land cover type map generation needs.

Hajarizadeh, Behzad, Jennifer MacLachlan, Benjamin Cowie e Gregory J. Dore. Population-level interventions to improve the health outcomes of people living with hepatitis B: an Evidence Check brokered by the Sax Institute for the NSW Ministry of Health, 2022. The Sax Institute, agosto 2022. http://dx.doi.org/10.57022/pxwj3682.

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Background An estimated 292 million people are living with chronic hepatitis B virus (HBV) infection globally, including 223,000 people in Australia. HBV diagnosis and linkage of people living with HBV to clinical care is suboptimal in Australia, with 27% of people living with HBV undiagnosed and 77% not receiving regular HBV clinical care. This systematic review aimed to characterize population-level interventions implemented to enhance all components of HBV care cascade and analyse the effectiveness of interventions. Review questions Question 1: What population-level interventions, programs or policy approaches have been shown to be effective in reducing the incidence of hepatitis B; and that may not yet be fully rolled out or evaluated in Australia demonstrate early effectiveness, or promise, in reducing the incidence of hepatitis B? Question 2: What population-level interventions and/or programs are effective at reducing disease burden for people in the community with hepatitis B? Methods Four bibliographic databases and 21 grey literature sources were searched. Studies were eligible for inclusion if the study population included people with or at risk of chronic HBV, and the study conducted a population-level interventions to decrease HBV incidence or disease burden or to enhance any components of HBV care cascade (i.e., diagnosis, linkage to care, treatment initiation, adherence to clinical care), or HBV vaccination coverage. Studies published in the past 10 years (since January 2012), with or without comparison groups were eligible for inclusion. Studies conducting an HBV screening intervention were eligible if they reported proportion of people participating in screening, proportion of newly diagnosed HBV (participant was unaware of their HBV status), proportion of people received HBV vaccination following screening, or proportion of participants diagnosed with chronic HBV infection who were linked to HBV clinical care. Studies were excluded if study population was less than 20 participants, intervention included a pharmaceutical intervention or a hospital-based intervention, or study was implemented in limited clinical services. The records were initially screened by title and abstract. The full texts of potentially eligible records were reviewed, and eligible studies were selected for inclusion. For each study included in analysis, the study outcome and corresponding 95% confidence intervals (95%CIs) were calculated. For studies including a comparison group, odds ratio (OR) and corresponding 95%CIs were calculated. Random effect meta-analysis models were used to calculate the pooled study outcome estimates. Stratified analyses were conducted by study setting, study population, and intervention-specific characteristics. Key findings A total of 61 studies were included in the analysis. A large majority of studies (study n=48, 79%) included single-arm studies with no concurrent control, with seven (12%) randomised controlled trials, and six (10%) non-randomised controlled studies. A total of 109 interventions were evaluated in 61 included studies. On-site or outreach HBV screening and linkage to HBV clinical care coordination were the most frequent interventions, conducted in 27 and 26 studies, respectively. Question 1 We found no studies reporting HBV incidence as the study outcome. One study conducted in remote area demonstrated that an intervention including education of pregnant women and training village health volunteers enhanced coverage of HBV birth dose vaccination (93% post-intervention, vs. 81% pre-intervention), but no data of HBV incidence among infants were reported. Question 2 Study outcomes most relevant to the HBV burden for people in the community with HBV included, HBV diagnosis, linkage to HBV care, and HBV vaccination coverage. Among randomised controlled trials aimed at enhancing HBV screening, a meta-analysis was conducted including three studies which implemented an intervention including community face-to-face education focused on HBV and/or liver cancer among migrants from high HBV prevalence areas. This analysis demonstrated a significantly higher HBV testing uptake in intervention groups with the likelihood of HBV testing 3.6 times higher among those participating in education programs compared to the control groups (OR: 3.62, 95% CI 2.72, 4.88). In another analysis, including 25 studies evaluating an intervention to enhance HBV screening, a pooled estimate of 66% of participants received HBV testing following the study intervention (95%CI: 58-75%), with high heterogeneity across studies (range: 17-98%; I-square: 99.9%). A stratified analysis by HBV screening strategy demonstrated that in the studies providing participants with on-site HBV testing, the proportion receiving HBV testing (80%, 95%CI: 72-87%) was significantly higher compared to the studies referring participants to an external site for HBV testing (54%, 95%CI: 37-71%). In the studies implementing an intervention to enhance linkage of people diagnosed with HBV infection to clinical care, the interventions included different components and varied across studies. The most common component was post-test counselling followed by assistance with scheduling clinical appointments, conducted in 52% and 38% of the studies, respectively. In meta-analysis, a pooled estimate of 73% of people with HBV infection were linked to HBV clinical care (95%CI: 64-81%), with high heterogeneity across studies (range: 28-100%; I-square: 99.2%). A stratified analysis by study population demonstrated that in the studies among general population in high prevalence countries, 94% of people (95%CI: 88-100%) who received the study intervention were linked to care, significantly higher than 72% (95%CI: 61-83%) in studies among migrants from high prevalence area living in a country with low prevalence. In 19 studies, HBV vaccination uptake was assessed after an intervention, among which one study assessed birth dose vaccination among infants, one study assessed vaccination in elementary school children and 17 studies assessed vaccination in adults. Among studies assessing adult vaccination, a pooled estimate of 38% (95%CI: 21-56%) of people initiated vaccination, with high heterogeneity across studies (range: 0.5-93%; I square: 99.9%). A stratified analysis by HBV vaccination strategy demonstrated that in the studies providing on-site vaccination, the uptake was 78% (95%CI: 62-94%), significantly higher compared to 27% (95%CI: 13-42%) in studies referring participants to an external site for vaccination. Conclusion This systematic review identified a wide variety of interventions, mostly multi-component interventions, to enhance HBV screening, linkage to HBV clinical care, and HBV vaccination coverage. High heterogeneity was observed in effectiveness of interventions in all three domains of screening, linkage to care, and vaccination. Strategies identified to boost the effectiveness of interventions included providing on-site HBV testing and vaccination (versus referral for testing and vaccination) and including community education focussed on HBV or liver cancer in an HBV screening program. Further studies are needed to evaluate the effectiveness of more novel interventions (e.g., point of care testing) and interventions specifically including Indigenous populations, people who inject drugs, men who have sex with men, and people incarcerated.

Farahbod, A. M., e J. F. Cassidy. Temporal variations in coda Q before and after the 2017 Barrow Strait earthquake (Mw 5.9) in Nunavut and the 2012 Haida Gwaii earthquake (Mw 7.8) in British Columbia. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/331095.

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In this study, we examine potential temporal changes in coda Q values for two significant Canadian earthquakes in different tectonic environments: the 2017 (Mw 5.9) Barrow Strait earthquake along Canada's northern margin and the 2012 (Mw 7.8) Haida Gwaii subduction earthquake on Canada's west coast. Waveforms from 124 earthquakes (2.0 &lt;/= M &lt;/= 4.6) for ~30 years prior to the January 8, 2017 Barrow Strait earthquake and 66 events (mainly aftershocks of M 2.0-5.3) in about 4 years after the mainshock recorded by the closest seismic station (RES) of the Canadian National Seismograph Network (CNSN) were utilized in this study. Based on our analysis, overall average of Q0 (Q at 1 Hz) decreased from 92 (before the mainshock) to 81. The most significant decrease in the frequency range between 2 and 16 Hz is observed for areas corresponding to ellipse parameter a2 of 50, 70 and 80 mainly related to aftershock activity. Precursory Q changes could not be evaluated before the mainshock due to the lack of reported seismicity within 100 km of the recording seismic station for almost 2 years from April 2015 to January 2017. Coda Q values before and after the October 28, 2012 Haida Gwaii earthquake in British Columbia show a similar pattern. Waveforms from 249 earthquakes (2.0 &lt;/= M &lt;/= 4.9) in 2 years before the mainshock and 498 events (2.5 &lt;/= M &lt;/= 6.3) in 2 years after the mainshock recorded by the three closest seismic stations of the CNSN were utilized. Overall average of Q0 decreased from 89 (before the mainshock) to 69 (station BNB), from 90 to 79 (station DIB) and from 86 to 78 (station VIB). In general, these results are in agreement with other global studies that show a decrease in Q0 following a major earthquake, likely the result of increased fracturing and fluids in the epicentral region.