Letteratura scientifica selezionata sul tema "571.7/4"
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Articoli di riviste sul tema "571.7/4"
Park, Chan-ran, Eun-ji Kim, Chang-gue Son, Jung-hyo Cho e Nam-hun Lee. "3 Cases of Cancer Patients Whose Natural Killer Cell Activity Improved with Traditional Korean Medicine Treatment: A Case Series". Journal of Internal Korean Medicine 42, n. 3 (30 giugno 2021): 444–54. http://dx.doi.org/10.22246/jikm.2021.42.3.444.
Testo completoKaplan, David Edward, Tamar H. Taddei, Ayse Aytaman, Kristel Hunt, Astrid Knott, Eric Dieperink, Michelle Baytarian et al. "Interim analysis of hepatocellular carcinoma (HCC) screening and survival in 4,087 veterans diagnosed with HCC from 2008 to 2010." Journal of Clinical Oncology 33, n. 3_suppl (20 gennaio 2015): 243. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.243.
Testo completoEbadi, Mona, Nurul Asikin-Mijan, Mohd Suzeren Md. Jamil, Anwar Iqbal, Emad Yousif, Ahmad Rifqi Md Zain, Tengku Hasnan Tengku Aziz e Muhammad Rahimi Yusop. "Palladium Nanoparticles on Chitosan-Coated Superparamagnetic Manganese Ferrite: A Biocompatible Heterogeneous Catalyst for Nitroarene Reduction and Allyl Carbamate Deprotection". Polymers 15, n. 1 (1 gennaio 2023): 232. http://dx.doi.org/10.3390/polym15010232.
Testo completoKratochvíl, Bohumil, Jan Ondráček, Karel Malý e László Csordás. "The molecular and crystal structure of benzamidinium bromoacetate". Collection of Czechoslovak Chemical Communications 53, n. 2 (1988): 294–300. http://dx.doi.org/10.1135/cccc19880294.
Testo completoShahinul, M., MJ Hussain, MMR Salim, B. Ahamed e M. Rahman. "Determination of Optimum Rate of Nitrogen, Phosphorus, Potassium and Boron for Leaf and Seed Yield of Lettuce". Bangladesh Journal of Agricultural Research 45, n. 4 (15 dicembre 2022): 455–71. http://dx.doi.org/10.3329/bjar.v45i4.63251.
Testo completoGori, Eleonora, Alessio Pierini, Ilaria Lippi, Noemi Boffa, Francesca Perondi e Veronica Marchetti. "Urinalysis and Urinary GGT-to-Urinary Creatinine Ratio in Dogs with Acute Pancreatitis". Veterinary Sciences 6, n. 1 (13 marzo 2019): 27. http://dx.doi.org/10.3390/vetsci6010027.
Testo completoSyarifuddin, S., H. Husin, M. Mahidin, J. Jakfar, N. Nurhazanah, F. Nasution, F. R. Nasri e H. D. Ramadhan. "Experimental study of calcium carbonate solution saturation in the separation process of palm kernel-shell mixtures using water clay bath systems". IOP Conference Series: Earth and Environmental Science 1356, n. 1 (1 giugno 2024): 012117. http://dx.doi.org/10.1088/1755-1315/1356/1/012117.
Testo completoGallocchio, Federica, Alessandra Moressa, Francesco Pascoli, Alessia Vetri, Anna Toffan, Tobia Pretto, Giuseppe Arcangeli, Roberto Angeletti e Antonia Ricci. "Effect of TiO2 Nanoparticle on Bioaccumulation of ndl-PCBs in Mediterranean Mussels (Mitilus galloprovincialis)". Animals 13, n. 7 (30 marzo 2023): 1208. http://dx.doi.org/10.3390/ani13071208.
Testo completoErber, Luke, Samantha Goodman, Caitlin Jokipii Krueger, Ivan Rusyn e Natalia Tretyakova. "Quantitative NanoLC/NSI+-HRMS Method for 1,3-Butadiene Induced bis-N7-guanine DNA-DNA Cross-Links in Urine". Toxics 9, n. 10 (2 ottobre 2021): 247. http://dx.doi.org/10.3390/toxics9100247.
Testo completoFeyerabend, S., S. Stefanovic, C. Gouttefangeas, M. Widenmeyer, D. Wernet, J. Hennenlotter, J. Bedke et al. "HLA-associated multipeptide vaccination in biochemically relapsed prostate cancer patients". Journal of Clinical Oncology 27, n. 15_suppl (20 maggio 2009): 5134. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.5134.
Testo completoTesi sul tema "571.7/4"
Carulli, Sonia. "Molecular basis of syndecan-1 mediated cell adhesion to laminin 332". Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10134.
Testo completoThe HSPG receptor syndecan-1 interacts with the carboxy-terminal LG4/5 domain in laminin 332 to participate in keratinocyte migration by inducing formation of cytoskeleton related protrusive structures. We have shown that syndecan-1 mediated cell adhesion occurs in heparan sulphate and chondroitin sulphate dependent manner and that these two glycosaminoglycan (GAG) chains bind independently to LG4/5 with different affinities. To identify residues involved in the interaction of the LG4/5 domain with syndecan-1 and to apprehend the molecular basis of the GAGs interaction specificity, we have used a site-directed mutagenesis approach of the recombinant LG4/5 fragment. The residues identified as conserved heparin binding residues throughout laminins, as well as “candidate” basic residues identified through predictive approaches, have been replaced by the neutral residue glutamine. All LG4/5 proteins carrying a hexa-histidine tag at their C-terminal end were expressed in mammalian cells. The produced proteins were purified and characterized biochemically. Circular dichroism studies performed on all mutagenised proteins showed that the overall structure of each mutant is comparable to that of the wild type protein. Heparin affinity chromatography analysis allowed us to identify a major heparin binding site in the LG4/5 domain surrounded by several minor GAG binding sites. Surface plasmon resonance analysis of mutated LG4/5 proteins-heparan sulphate interaction confirmed these results. These findings were well correlated with our in cellulo syndecan-1 mediated cell adhesion as the lack of this major heparin binding site totally abrogated cell adhesion. Pull down experiments allowed us to show that this heparin binding site sequence is responsible not only for the interaction of the receptors syndecan-1 but also for syndecan-4 suggesting that additional cellular functions may be carried by this sequence. Our structural predictions suggest that the LG4/5 in laminin 332 encompasses a major GAG binding site surrounded by a track of converging positively charged residues
Jadid, Nurul. "Etude moléculaire et fonctionnelle du rôle des isoprénoïdes cytosoliques (dolichol et stérol) au cours du développement chez Arabidopsis thaliana". Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ118.
Testo completoIsoprenoids represent important cell constituents synthesized in many living organisms. ln plants, isoprenoid biogenesis occurs in three compartments : plastids, the endoplasmic reticulum-cytosol and mitochondrie.We focused on the molecular and functional studies of the role of Iwo cytosolic isoprenoids ( dolichol andsterol) in the development of plants. The key Io our strategy is the targeted silencing of specific Arabidopsis genes using the RNAi technology (knockdown) and the identification of T-DNA insertion mutants (knockout). ln the first chapter, we show that isoprenoids are involved indirectly in protein N-glycosylation via Dolichol P-Mannose derived from dolichol phosphate mannose synthase (DPMS). We demonstrate that plant DPMSis organized as a heteromeric enzyme complex localized in the endoplasmic reticulum (ER) and consists of DPMS1 acting as the catalytic core and two interacting subunits DPMS2 and DPMS3. The DPMS1-RNAiand dpms1 lines display an altered N-glycosylation pattern and exhibit extensive chlorosis, strong inhibition of root growth and hypersensitivity to ammonium. These phenotypic defects are associated with an «unfolded protein response» in the ER. These data demonstrate that the DPMS genes are essential for the protein N-glycome and plant development. ln the second chapter, we focused on the potentiel roles of sterol biosynthetic intermediates (SBls) in plant development using ERG28 protein, a component of the sterol C-4 demethylation (SC4DM) complex, as a target. We demonstrate that ERG28 is localized in ER and tethers 3 enzymes, sterol 4alpha-methyl oxidase, 4alpha carboxysterol-C3-dehydrogenase/C4- decarboxylase and sterone ketoreductase. We show that the Arabidopsis ERG28-RNAi and erg28 lines develop the hallmarks of altered polar auxin transport (PAT) including the differentiation of pin-like inflorescences, the loss of apical dominance, leaf fusion and inhibition root growth. The observed phenotypes correlate with the accumulation of methylene-cycloartanol-4-carboxy-4-methyl, a cryptic SBI. Our data provide a new level of interaction between sterols and auxin
Shulov, Ievgen. "Synthesis of fluorescent organic nanoparticles for biological applications". Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ001/document.
Testo completoQuantum dots (QDs) and fluorescent silica nanoparticles (NPs) have impacted the domain of bioimaging by their high brightness and robust photostability. In comparison to QDs, organic NPs can be even brighter and fully biodegradable, as well biocompatible and not containing toxic elements inside. Herein, we developed four types of these NPs. At first, lipid nano-droplets loaded with lipophilic flavone and Nile Red dyes for in vivo imaging in zebrafish; second, ion-association of alkyl rhodamine B with fluorinated tetraphenylborate (TPB) counterions result in 11-20 nm NPs with fluorescence quantum yield up to 60%; third, 7 nm micellar NPs obtained by co-assembly of cyanine amphiphiles with TPB counterions; finally, polymerization of calix[4]arene micelles using bi-functional cyanine crosslinkers giving 7 nm NPs, that show fluorogenic behavior and high intracellular stability. These NPs, being of smaller size and brighter than QDs, have emerged as promising tools for bioimaging
Pugieux, Céline. "Meiotic spindle assembly on chromatin micropatterns : investigating the roles of Augmin, Kinesin-10 and Kinesin-4". Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ011.
Testo completoCell division is essential for the survival of every living organism. During this process, the chromosomes of the dividing cell are transmitted to the two daughter cells. The partition of the chromosomes is orchestrated by a transient sub-cellular structure called the mitotic spindle (or meiotic spindle in gamete cells). The spindle is composed of microtubules, numerous proteins and molecular motors, which interact in an intricate and yet precise manner leading to a highly dynamic and complexstructure. As some molecular mechanisms remain elusive, we have chosen to address the question of meiotic spindle assembly in Xenopus egg extracts. Xenopus laevis is a model system that is evolutionary close to human, and suitable for cell division studies. We have combined this with an in vitro assay - spindle array - which we developed prior to this work, and which provides advantages over existing approaches. A spindle array is composed of chromatin-coated beads that are immobilized according to geometrical patterns obtained by microcontact printing. The assembly of meiotic spindles wasvisualized by time-lapse fluorescence confocal microscopy. Using these tools, we first addressed the role of augmin in the assembly of meiotic spindles. Augmin is a recently identified protein complex that has been hypothesized to induce microtubule nucleation from the side of preexisting microtubules. By depleting augmin, we found that microtubule nucleationwas reduced and that spindles were morphologically impaired. Spindles were predominantly multipolar but finally reached bipolarity as a result of a newly uncovered augmin-independent microtubule nucleation pathway from acentrosomal poles. Our results thus reveal that augmin is essential for the proper establishment of the microtubule scaffolding and the bipolarity ofacentrosomal spindles. Secondly, we investigated the functions of the chromokinesins kinesin-4 (Xklp1) and kinesin-10 (Xkid)in acentrosomal spindle architecture and motions. Xkid plays a major role in the polar ejection forces leading chromosome movements during congression while the main function of XKlp1 is to regulate microtubule dynamics. We studied spindle assembly in depleted extracts and we report that Xkid limits the dynamics of spindle longitudinal movements, contributes to spindle bipolarity and affects spindle length while XKlp1 controls the spindle microtubule mass. Altogether these findings contribute to a better understanding of meiotic spindle assembly and confirm the pertinence of our method to study spindle morphogenesis
Guibert, Mathilde. "Altération du phénotype chondrocytaire : Rôle de l’homéostasie locale de facteurs modulant la balance Pi/Ppi". Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0160/document.
Testo completoOsteoarthritis (OA) is the most common form of chronic joint disease, characterized by cartilage degeneration that results from complex changes in the chondrocyte phenotype. The presence of phosphate-containing microcrystals in the injured cartilage areas suggests the contribution of the phosphocalcic metabolism in the phenotype switch of chondrocytes during the disease. Numerous studies have shown that elevated concentrations of extracellular inorganic phosphate (ePi) or inorganic pyrophosphate (ePPi) have, respectively, activating or repressive mineralizing effects on articular cartilage. As Fibroblast Growth Factor 23 (FGF23) plays a major role in regulating concentrations of Pi, FGF23 is an attractive candidate to participate in the phenotype switch of the articular chondrocyte observed in OA. Moreover, we recently demonstrated that ePPi also prevents the in vitro dedifferentiation of articular chondrocyte in rats, an effect mostly triggered by Ank-induced release of PPi. This suggests that PPi may be an attractive candidate to prevent the phenotype switch of the articular chondrocyte. Firstly, we showed that FGF23 expression was higher in OA samples than in healthy one. When stimulated with increasing concentrations of FGF23, human OA chondrocytes displayed a sustained expression of markers of hypertrophy such as COL10A1, VEGF and MMP13. We demonstrated further, that MMP13 expression was mainly dependent on FGFR1 and independent of Klotho and was strongly regulated by the MEK/ERK cascade and to a lesser extent by the PI-3K/AKT pathway. Secondly, we showed that FGF23 and FGFRs were produced more importantly during ATDC5 differentiation and that FGF23 stimulation increased hypertrophic markers expression and mineralization in a synergic manner with Pi. In the second part, we showed that human OA chondrocytes stimulated with PPi displayed a decreased expression of collagen components of the matrix and sustained expression of MMPs, fibronectin and integrins. We demonstrated further that PPi stimulation mostly activates p38 pathway and to a lesser extent ERK pathway to regulate the expression of its target genes in an Ank-independent manner. Finally, we demonstrated that FGF23 stimulation increased Pit-1, ENPP1 and Ank expressions and PPi production by human OA chondrocyte. Altogether, the results obtained in this study demonstrate that FGF23 locally promotes differentiation of OA chondrocytes towards a hypertrophic phenotype and may therefore be considered as an aggravating factor for OA. In contrast to previous data obtained in rats, we demonstrated that PPi promotes matrix-remodeling of human OA chondrocytes and might contribute to FGF23 pro-hypertrophic effect
Libri sul tema "571.7/4"
Transport Phenomena in Biological Systems (2nd Edition). 2a ed. Prentice Hall, 2007.
Cerca il testo completoTransport Phenomena in Biological Systems. Pearson Education, Limited, 2007.
Cerca il testo completoCell Signaling: Principles and Mechanisms. CRC Press LLC, 2024.
Cerca il testo completoStructure and Function in Cell Signalling. Wiley, 2008.
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