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Abdellaoui, K., I. Z. Hager, Hosam A. Othman, A. Boumaza e Najoua Kamoun. "Structural, Optical and Thermal Characterizations of Lithium Borate Glasses Containing the Barite". Defect and Diffusion Forum 397 (settembre 2019): 24–38. http://dx.doi.org/10.4028/www.scientific.net/ddf.397.24.
Testo completoAbstract (sommario):
A glass system was prepared according to the formula 60mol%B2O3 – x mol %barite – (40-x) mol %Li2O, where x=0, 5, 7.5, 10, 15 and 20 mol%. The amorphous nature of the prepared glasses was confirmed through X-ray diffraction. The prepared glasses were also characterized by FTIR spectroscopy, UV-vis absorption spectroscopy and the differential thermal analysis (DTA). The density is found to increase and this is because of the higher molecular of the added barite. The molar volume also increases with increasing barite content that indicates the structural changes occurred in borate network that were also confirmed using FTIR. Increasing the concentration of barite shifts the UV cutoff edge toward higher wavelengths from about 300 nm at 0 mol% barite to about 400 nm at 15 mol% of barite. Glass transition temperature (Tg) is found to increase with the increasing barite content. When analyzed by photoluminescence, the samples exhibit luminescence emission centered at around 400, 415, 480, 430, 485, 520, 545, and 570 nm when excited at 300 nm wavelength. The emission peaks at 420 nm, and 440 nm were assigned to F center emission. Between 440 nm and 520 nm it is rather the effect of the presence of the impurities.
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Piechocka-Kłos, Maria. "Wróżbiarstwo i praktyki magiczne w świetle dokumentów wczesnochrześcijańskich synodów oraz ustaw państwowych pierwszych cesarzy chrześcijańskich (IV-VI w.)". Studia Warmińskie 57 (31 dicembre 2020): 361–82. http://dx.doi.org/10.31648/sw.5340.
Testo completoAbstract (sommario):
Chrześcijanie późnego antyku, mimo rosnącej roli chrześcijaństwa i uznania go za religię państwową, żyli w świecie, który nadal obfitował w różnorodne formy kultu pogańskiego. Pogańskie wróżbiarstwo i liczne praktyki magiczne wciąż miały doskonałe warunki do rozwoju. Kulturowa i religijna działalność człowieka, mimo zakazów państwowych i kościelnych, w naturalny sposób utrzymywała potrzebę podejmowania prób, za pomocą specjalnych środków i technik, poznania przyszłości lub wpłynięcia na los i przebieg wydarzeń. Takiej sytuacji sprzyjał fakt, że chrześcijanie nie żyli w izolacji, lecz współegzystowali z poganami na terenie Imperium Romanum. W niniejszej publikacji przedstawiono szczegółową analizę postanowień synodów obradujących od IV do VI w. w odniesieniu do wróżbiarstwa i praktyk magicznych. Analizie w tej kwestii poddano m.in. kanony ogłoszone w Elwirze (306), Arles (314), Laodycei we Frygii (koniec IV w.), Saliq w Seleucji-Ktezyfonie (410), Irlandii (456–465), Vannes w Bretanii (461–491), Galii (ok. 475–485), Agde (506), Orleanie (511), Eleuze (551) dwa razy ponownie w Seleucji-Ktezyfonie (544 i 554) oraz w Bradze (572) i Narbon (589). W celu pełniejszego ukazania przywołanego w temacie zagadnienia omówiono również prawodawstwo cesarskie, ogłaszane w sprawach religijnych przez pierwszych chrześcijańskich cesarzy rzymskich, począwszy od Konstantyna aż do Arkadiusza. Analizie poddano przede wszystkim ustawy zawarte w 16 księdze Kodeksu Teodozjańskiego. W tym kontekście przywołano edykty cesarskie ogłoszone w latach 341, 381, 385, 392, 395 oraz 396.
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Craig, J. B. "Electrochemical oxygen technology Kim Kinoshita, Wiley, Chichester, 1992. Pages ix + 431. £105.00 ISBN 0-471-570-435." Talanta 40, n. 9 (settembre 1993): 1475. http://dx.doi.org/10.1016/0039-9140(93)80233-h.
Testo completo
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Krupa, Michał. "Notki recenzyjne". Z Badań nad Książką i Księgozbiorami Historycznymi 10 (11 dicembre 2019): 397–410. http://dx.doi.org/10.33077/uw.25448730.zbkh.2016.131.
Testo completoAbstract (sommario):
Pamiętniki i relacje w zbiorach rękopiśmiennych BN (wydanie drugie poprawione i rozszerzone), oprac. Danuta Kamolowa przy współudziale Teresy Sieniateckiej, Warszawa: Biblioteka Narodowa, 2015, 539, [1] s., [26] k. tabl.: il., ISBN 978-83-7009-623-6 – Katarzyna Seroka [397-398]
Anna Kocot, Artyści „czarnej sztuki”. Typografia druków Floriana Unglera i Macieja Wirzbięty, Kraków: Księgarnia Akademicka, 2015, ss. 416, ISBN/ISSN 978-83-76384-60-3 – Anna Kamler [398-403]
Justyna Kiliańczyk-Zięba, Sygnety drukarskie w Rzeczypospolitej XVI wieku: źródła ikonografi czne i treści ideowe, Kraków: Wydawnictwo Towarzystwa Naukowego „SocietasVistulana”, 2015, ss. 342, [1]: il., ISBN 978-83-61033-89-9 – Katarzyna Seroka [403-405]
Catalogue of books from the Library of Sigismund II Augustus, King of Poland, in the collection of the National Library of Russia in Saint Petersburg, ed. by Maria I. Tkachenko, Maria Brynda, National Library of Poland (Warsaw), National Library of Russia (Saint Petersburg),Warsaw: National Library of Poland, 2015, 198 [1] s., [21] s. tabl., ISBN 978-83-7009-621-2 – Karolina Figaszewska [405-406]
Joanna Matyasik, Polonika XVI-XVII w. ze zbiorów Wojewódzkiej i Miejskiej Biblioteki Publicznej w Bydgoszczy. Katalog, Bydgoszcz: Wojewódzka i Miejska Biblioteka Publiczna im. Dr. Witolda Bełzy, 2015, ss. 345, ISBN 978-83-85979-21-0; 978-83-62545-86-5 – Agnieszka Chamera-Nowak [406-409]
Polski wkład w przyrodoznawstwo i technikę: słownik polskich i związanych z Polską odkrywców, wynalazców oraz pionierów nauk matematycznoprzyrodniczych i techniki, t. 1-4, red. nauk. Bolesław Orłowski, Warszawa: Instytut Historii Nauki im. Ludwika i Aleksandra Birkenmajerów Polskiej Akademii Nauk, Instytut Pamięci Narodowej – Komisja Ścigania Zbrodni przeciwko Narodowi Polskiemu, 2015, t. 1 ss. 521, t. 2 ss. 437, t. 3 ss. 511, t. 4 ss. 543, ISBN 978-83-8606-229-4; 978-83-8606-228-7; 978-83-7629-829-0; 978-83-7629-828-3; 978-83-7545-569-4; 978-83-7545-570-0 – Sarah Skumanov [409-410]
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Wu, Ming, Fang Long, Hao Ran Geng e Fang Yang. "Effects of Heat Treatment on Microstructure and Properties of AZ91D Magnesium Alloy". Key Engineering Materials 575-576 (settembre 2013): 410–13. http://dx.doi.org/10.4028/www.scientific.net/kem.575-576.410.
Testo completoAbstract (sommario):
The microstructure, hardness and corrosion resistance of AZ91D alloy were investigated under different solution treatments and artificial aging conditions.When ascast AZ91D alloy was heat treated at 415°C by solution treatmentfor 12 h and artificially aged at 200°C, the volume fraction of precipitates increased with the aging time up to 10 h.When ascast AZ91D alloy was treated at 430°C by solution treatment for 12 h and artificially aged at 200°C for 10h, the volume fraction of precipitates reached a peak value.The results of the corrosion test showed that a high corrosion resisting of the second phase precipitates was beneficial to improving the strength and hardness. Solution treatment at 445°C temperature for 12 h destroied the consecutiveness of β-Mg17Al12 phases.
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Juknevičienė, Renata, Justas Simonavičius, Aurimas Mikalauskas, Kamilė Čerlinskaitė-Bajorė, Mattia Arrigo, Vytautas Juknevičius, Irina Alitoit-Marrote et al. "Soluble CD146 in the detection and grading of intravascular and tissue congestion in patients with acute dyspnoea: analysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort". BMJ Open 12, n. 9 (settembre 2022): e061611. http://dx.doi.org/10.1136/bmjopen-2022-061611.
Testo completoAbstract (sommario):
ObjectivesTo evaluate the potential of soluble cluster of differentiation 146 (sCD146) in the detection and grading of congestion in patients with acute dyspnoea.DesignSubanalysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort.SettingTwo Lithuanian university centres.ParticipantsAdult patients with acute dyspnoea admitted to the emergency department.MethodsCongestion was assessed using clinical and sonographic parameters. All patients underwent sCD146 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing.ResultsThe median value of sCD146 concentration in the study cohort (n=437) was 405 (IQR 315–509) ng/mL. sCD146 was higher in patients with peripheral oedema than in those without (median (IQR) 472 (373–535) vs 400 (304–501) ng/mL, p=0.009) and with pulmonary rales than in those without (439 (335–528) vs 394 (296–484) ng/mL, p=0.001). We found a parallel increase of estimated right atrial pressure (eRAP) and sCD146 concentration: sCD146 was 337 (300–425), 404 (290–489) and 477 (363–572) ng/mL in patients with normal, moderately elevated and high eRAP, respectively (p=0.001). In patients with low NT-proBNP, high sCD146 distinguished a subgroup with a higher prevalence of oedema as compared with patients with low levels of both biomarkers (76.0% vs 41.0%, p=0.010). Moreover, high sCD146 indicated a higher prevalence of elevated eRAP, irrespective of NT-proBNP concentration (p<0.05).ConclusionsCD146 concentration reflects the degree of intravascular and tissue congestion assessed by clinical and echocardiographic indices, with this association maintained in patients with low NT-proBNP. Our data support the notion that NT-proBNP might represent heart stretch while sCD146 rather represents peripheral venous congestion.
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Putiš, Marián, Peter Ivan, Milan Kohút, Ján Spišiak, Pavol Siman, Martin Radvanec, Pavel Uher et al. "Meta-igneous rocks of the West-Carpathian basement, Slovakia: indicators of Early Paleozoic extension and shortening events". Bulletin de la Société Géologique de France 180, n. 6 (1 ottobre 2009): 461–71. http://dx.doi.org/10.2113/gssgfbull.180.6.461.
Testo completoAbstract (sommario):
Abstract The paper reviews the main West-Carpathian Early Paleozoic metamorphosed originally sedimentary-magmatic complexes, dated by SHRIMP on zircons, as indicators of crustal extension and shortening events. Igneous precursors of a Layered Amphibolite Complex (LAC) – fractionated upper mantle gabbros to diorites, dated at 503 ± 4 and 492 ± 4 Ma from the North-Veporic, or 480 ± 5 and 450 ± 6 Ma from the Tatric basement are contemporaneous with subaluminous to metaluminous I-type (507 ± 4 Ma, the South-Veporic basement), peraluminous S-type (497 ± 4 Ma, the South-Veporic basement; 516 ± 7, 485 ± 6 and 462 ± 6 Ma, the North-Veporic basement; 497 ± 6, 472 ± 6 and 450 ± 6 Ma, the Tatric basement), alkaline A-type (511 ± 6 Ma, South-Veporic basement) granitic orthogneisses and calcalkaline rhyolitic (482 ± 6 Ma) and dacitic (476 ± 7 Ma) metavolcanics (Gemeric basement), indicating a magmatic immature back arc setting. The ages point to Middle/Late Cambrian, Early and Late Ordovician magmatic phases, coeval with the extension in the northern Gondwana margin. Separation of an inferred Avalonian and/or Galatian terranes distal continental ribbon corresponds with the opening of a Medio-European Basin. A 430-390 Ma dated MP/HP metamorphic event, recorded in the LAC and associated orthogneisses, occurred in the area of thinned immature back arc basin crust due to closure of the Medio-European Basin. Thus a distal Gondwana continental ribbon north of this basin could be an eastward lateral pendant of Armorica, derived from Galatian terrane. Metaophiolites of the Pernek Group (a metagabbrodolerite dated at 371 ± 4 Ma) in the Tatric basement, analogous to island-arc tholeiites and back-arc basin basalts, indicate a back-arc basin setting north of a 430-390 Ma old northward dipping subduction/collision zone, dividing the northward drifting western Galatian terrane microplate from the Gondwana margin. Some metabasites of the Gemeric basement might indicate Late Devonian to Mississippian opening of a peri-Gondwanan Paleotethyan oceanic basin: a 383 ± 3 Ma old remelted metagabbro (482 ± 9 Ma) from the Klátov gneiss-amphibolite complex, ca. 385 Ma old porphyritic metabasite of the Zlatník ophiolite complex, as well as a 350 ± 5 Ma old HP metabasite as tectonic fragment within the Rakovec Group. The closure of Devonian-Mississippian basins, accompanied by medium-pressure (the Pernek Group) to high-pressure (blueschist to eclogitic tectonic fragments in greenschist facies rocks of the Rakovec Group) metamorphism, occurred in late Carboniferous to early Permian, when Paleotethyan realm complexes accreted to a Galatian terrane microplate, the latter represented by the older and the higher-grade Tatric and Veporic basement complexes.
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Ziogas, Dimitrios, Kiruthikah Thillai, Ippokratis Korantzis, MH Ruhe Chowdhury, Dionysios Papadatos-Pastos, Abid Suddle, John O'Grady, Nigel Heaton, Paul J. Ross e Debashis Sarker. "Outcomes and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma (HCC)." Journal of Clinical Oncology 33, n. 3_suppl (20 gennaio 2015): 435. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.435.
Testo completoAbstract (sommario):
435 Background: HCC is the third commonest malignancy worldwide, with the highest incidence rates in patients over 75 years of age. Although sorafenib is used for patients with advanced HCC, there are concerns about the outcomes and tolerability in this age group. Methods: We conducted a retrospective study of 190 patients treated with sorafenib (177 with sorafenib alone, 17 patients with a combination of sorafenib and erlotinib/placebo within the SEARCH trial). Patient demographics and outcomes were recorded. Results: 190 patients were identified with a median age of 66 (26-87). 151 patients were <75 years old (yrs) and 39 patients were >75. 157 patients were male and 33 female. Underlying liver disease in the over 75 group were: non-alcoholic fatty liver disease (N=14, 35.9%), unknown aetiology (N=14, 35.9%), alcoholic liver disease (N=7, 17.9%), hepatitis C (N=2, 5.1%), hepatitis B (N=1, 2.56%,) and autoimmune hepatitis (N=1, 2.56%). 33 patients were Child-Pugh A status when starting sorafenib (A5=25, A6=8) and 6 patients were Child-Pugh B (B7=5, B8=1). There was no statistically significant difference in OS between patients over the age of 75 and younger (7.1m for >75 yrs and 10.4 <75 yrs p=0.360), or in PFS (4.2m vs. 6.8m [p=0.539]). There was also no increase in G3/4 toxicities between both groups of patients with comparable incidences of G3/4 diarrhoea (4.7% <75 vs. 2.6% ≤75 p=0.481), skin toxicity (6.6% vs. 5.1% p=0.537), fatigue (7.3% vs. 7.7% p =0.58) and deteriorating liver function (2.6% vs. 7.3% p = 0.25). There was no difference between the incidence of dose reductions or interruptions (34% vs. 35.9% p=0.5). Conclusions: Our study suggests that patients aged 75 or older appear to tolerate treatment with sorafenib well with comparable toxicities to those less than 75. We also found no significant differences in survival. With an aging population and increasing incidences of HCC, further prospective evidence is needed to identify safety and survival outcomes in this important group of patients.
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Kubáň, Vlastimil, Josef Hedbávný, Irena Jančářová e Milan Vrchlabský. "Spectrophotometric investigation of interactions of sulfophthalein dyes with surfactants". Collection of Czechoslovak Chemical Communications 54, n. 3 (1989): 622–32. http://dx.doi.org/10.1135/cccc19890622.
Testo completoAbstract (sommario):
The effect of cationic (hexadecylpyridinium bromide, hexadecyltrimethylammonium bromide, Septonex), anionic (sodium dodecyl sulfate) and nonionic (Brij 35, Triton X-100) surfactants on the deprotonation of the phenolic oxygen in bromophenol red, bromophenol blue and bromocresol green is studied. The conditional dissociation constants Kai* depend on the surfactant concentration and, in the alkylpyridinium surfactant series, on the alkyl chain length at a constant concentration of inert electrolyte, and on the concentration of the inert electrolyte (Cl-, Br-, NO3-, SO42-, H2PO4-, CH3COO-, HCOO-, ClO4-) or of the sulfophthalein dye at a constant concentration of a cationic surfactant. In acid and alkaline solutions, cationic surfactants (tensides, T) and the dyes (H2L) form ionic associates with the stoichiometric composition {T+, LH-} and {T2+, L2-}, respectively, exhibiting absorption maxima at 400-430 nm (ε = 1.3-2.0 m2 mmol-1) and at 570-630 nm (ε = 3.5-4.5 m2 mmol-1), respectively, formation of these associates was confirmed for chloroform extracts by the continuous variations and molar ratios methods.
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Zhu, Xinhua, Yong Zhou, Yuzi Zhang e Shangli Cai. "Genomic somatic alterations of human epidermal growth factor-2 (HER2) gene: A pan-cancer analysis." Journal of Clinical Oncology 37, n. 15_suppl (20 maggio 2019): 3112. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3112.
Testo completoAbstract (sommario):
3112 Background: Human epidermal growth receptor 2 (HER2) is a well-known oncogenic drive gene with multiple targeted therapeutic options. In this study, we aim to assess the landscape of HER2 alterations in solid tumors and evaluate the feasibility of circulating tumor DNA (ctDNA) tested by next-generation sequence (NGS) as a tool to detect HER2 alterations. Methods: Alterations of HER2 by NGS (Illumina NextSeq 500) were queried in 3D Medicines database. The mean depth of tissue and circulating tumor DNA (ctDNA) test was 500X and 5000X, respectively. 11,013 patients tested using tumor tissue and 6,970 patients tested using ctDNA were included in this analysis. Results: Of 11,013 patients tested using tumor tissue, any HER2 and known or likely deleterious HER2 mutations were identified in 739 (6.7%) and 531 (4.8%) patients, respectively. Of 531 patients who carried known or likely deleterious HER2 mutations, 263 (49.5%) had HER2 amplification and 259 (48.8%) had single nucleotide variations (SNVs). Across all tumor types, breast cancer was found to have the highest frequency of HER2 amplification (14.9%, 48/323), followed by gastric cancer (6.6%, 31/470) and biliary tract cancer (5.8%, 33/571). Moreover, 11% (8/73) of duodenal cancer, 4.5% (7/154) of urothelial cancer, 3.8% (18/470) of gastric cancer, 3.1% (142/4555) of lung cancer, 2.9% (17/571) of biliary tract cancer, 2.8% (44/1562) of colorectal cancer and 2.7% (9/323) of breast cancer carried known or likely deleterious HER2 SNVs. Of 6970 patients tested using ctDNA, any HER2 and known or likely deleterious HER2 mutations were identified in 592 (8.5%) and 277 (4.0%) patients, respectively. In the ctDNA cohort, 15.7% (36/230) of breast cancer and 3.1% (5/161) of biliary tract cancer carried HER2 amplification. However, 11.6% (20/173) of gastric cancer had HER2 amplification tested by ctDNA which was higher than that tested using tissue. Furthermore, 5.6% (13/230) of breast cancer, 4.5% (2/44) of urothelial cancer, 3.4% (6/173), 2.5% of biliary tract cancer and 2.0% (94/4586) lung cancer harbored known or likely deleterious HER2 SNVs in ctDNA cohort. Conclusions: HER2 alterations existed across tumor types and the landscape of genomic alterations in HER2 gene varied according to different type of tumor. In addition, ctDNA can be used as a potential tool to detect HER2 alterations.
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Hansen, Marianne, Brittmarie Sandström, Mikael Jensen e Sven S. Sørensen. "Casein Phosphopeptides Improve Zinc and Calcium Absorption from Rice‐Based but not from Whole‐Grain Infant Cereal". Journal of Pediatric Gastroenterology and Nutrition 24, n. 1 (gennaio 1997): 56–62. http://dx.doi.org/10.1002/j.1536-4801.1997.tb01452.x.
Testo completoAbstract (sommario):
Background:Casein phosphopeptides (CPP) are phosphorus‐rich peptide fragments of casein, assumed to contribute to the high bioavailability of calcium from milk.Methods:The effect of casein phosphopeptides on calcium and zinc absorption from infant foods was investigated. Twenty‐two men and women were given single test meals extrinsically labeled with Ca and Zn. Absorption was calculated from measurements on whole‐body retention of the radioisotopes. Each subject was given either rice‐based cereal (n = 11) or whole‐grain cereal (n = 11) on three occasions together with 250 ml water and added 0, 1, and 2 g CPP in random order. One serving of rice‐based cereal contained 481 mg Ca and 1.29 mg Zn: whole‐grain cereal contained 541 mg Ca and 1.77 mg Zn. One and 2 g of CPP contributed with additional 69 and 138 mg Ca, respectively.Results:From rice‐based cereal, fractional calcium absorption was not affected by CPP addition (mean ± SD): 16.0 ± 4.0% (no CPP), 17.6 ± 4.5% (1 g CPP), and 15.8 ± 4.3% (2 g CPP), while the total quantity of calcium absorbed was significantly improved: 7 ± 19 mg, 97 ± 25 mg, and 98 ± 26 mg, respectively (p = 0.0004). Fractional zinc absorption as well as total quantity of zinc absorbed were increased with addition of CPP: 19.4 ± 9.0% (0.25 ± 0.12 mg), 25.2 ± 7.5% (0.33 ± 0.10 mg) and 23.9 ± 5.4% (0.31 ± 0.07 mg) at the three CPP levels (p = 0.04). From whole‐grain cereal, CPP had no effect on the percentage or actual quantity of calcium absorbed: 17.0 ± 3.2% (92 ± 18 mg), 17.2 ± 4.5% (105 ± 27 mg), and 15.0 ± 4.6% (102 ± 31 mg), respectively. Zinc absorption was also not influenced by CPP: 16.0 ± 5.1% (0.28 ± 0.09 mg), 15.3 ± 3.1% (0.27 ± 0.06 mg) and 18.1 ± 4.4% (0.32 ± 0.08 mg), respectively.Conclusions:CPP addition improved calcium and zinc absorption from rice‐based cereal, while no effect was seen from whole‐grain cereal.
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Butkovskaya, L. K., V. Е. Mudrova e А. О. Polyakov. "Bioenergy estimation of spring barley and oat varieties’ cultivation depending on seed-sowing rates in the Krasnoyarsk forest-steppe". Grain Economy of Russia 16, n. 3 (16 luglio 2024): 78–84. http://dx.doi.org/10.31367/2079-8725-2024-92-3-78-84.
Testo completoAbstract (sommario):
The purpose of the current study was a bioenergy estimation of different seed sowing rates of spring barley and oat varieties in the conditions of the Krasnoyarsk forest-steppe. The trials were carried out in the village of Minino, Emelyanovsky district, Krasnoyarsky Krai in 2021–2023. The objects of the study were the spring barley varieties ‘Abalak’, ‘Takmak’, ‘Oplot’, ‘Biom’ and the spring oat varieties ‘Tubinsky’, ‘Sayan’, ‘Kazyr’, ‘Uspekh’. Experimental schemes were as follows: barley varieties with seeding rates of 3.5, 4.0, 4.5 million germ. grains per hectare; oat varieties with seeding rates of 4.0, 4.5, 5.0 million germ. grains per hectare. High yields (5.60–5.71 t/ha) were produced by the barley varieties ‘Oplot’ and ‘Takmak’, while other varieties produced less on 0.9–1.4 t/ha. There has been revealed that the reproduction coefficient of barley seeds increased to 34.6 at a seed-sowing rate of 3.5 million germ. grains per hectare and decreased to 22.2–31.3 at a seed-sowing rate of 4.5 million germ. grains per hectare. There has been established that among oats, the variety ‘Tubinsky’ produced the highest yield of 4.79 t/ha at a seeding rate of 5.0 million germ. grains per hectare, followed by the variety ‘Sayan’ with 4.85 t/ha, the new promising variety ‘Uspekh’ with 4.67 t/ha and ‘Kazyr’ with 4.53 t/ha. The reproduction coefficient reached 26.9–29.7 with 4.0 million germ. grains per hectare and 21.3–23.5 at 5.0 million germ. grains per hectare. The energy estimation has shown that the optimal seed-sowing rate is 4.5 million germ. grains per hectare for barley varieties and 4.0 million germ. grains per hectare for oat varieties. The total energy increase (the difference between the total energy and energy costs) was 94.4 and 83.2 GJ/ha for the barley varieties ‘Takmak’ and ‘Oplot’, respectively and 58.9 and 59.0 GJ/ha for the oat varieties ‘Tubinsky’ and ‘Sayan’.
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Korshunov, F. P., N. E. Zhdanovich e D. N. Zhdanovich. "Influence of high-temperature annealing on the characteristics of fast electron-irradiated p-n-structures based on neutron doped silicon". Proceedings of the National Academy of Sciences of Belarus. Physics and Mathematics Series 55, n. 4 (7 gennaio 2020): 489–97. http://dx.doi.org/10.29235/1561-2430-2019-55-4-489-497.
Testo completoAbstract (sommario):
The investigation results of the annealing influence (Тann = 300–800 ºС) on the minority charge currier lifetime tP in the n-base of p-n-structures, manufactured on the base of neutron transmutation doped silicon (NTD) КОФ300, irradiated at room temperature by different fluences (F = 1 · 1014 – 3 · 1016 cm–2) of electrons with the energy of Еe = 4 MeV are presented. It is established that at low electron fluences (F = 1 · 1014 cm–2), the annealing of minority charge currier lifetime tP in the n-base of p-n-structures occurs in two stages: the first – 320–400 ºС and the second – 550–650 ºС. At higher electron fluences (F = 5 · 1015–2 · 1016 cm–2), three annealing stages occur: the first – 400–450 ºС, the second – 520–650 ºС and the third – 710–770 ºС. At this, the structure barrier capacitance C dependences on Тann at high electron fluences show the geometry capacitance up to the annealing temperatures Тann = 400 ºС. In the annealing temperature range of Тann = 420–570 ºС, the increase in С with maximum is seen at Тann = 480 ºС and a subsequent decrease in the geometry capacitance is seen in the annealing temperature range of Тann = 600–670 ºС, and then again the increase in С occurs in the annealing temperature range of Тann = 720–770 ºС reaching the С values corresponding to those of the non-irradiated samples in the annealing temperature range of Тann = 770–800 ºС. The analysis of the DLTS-spectra of the investigated structures has allowed establishing the formation in the annealing process of the deep acceptor level ЕС – 0.68 eV at Тann > 400 ºС, the deep donor level ЕС – 0.32 eV in the annealing temperature range of Тann = 420–570 ºС and the deep acceptor level ЕС – 0.53 eV at Тann > 700 ºС, which satisfactorily explains the dependences of t P and С on Тann obtained in this paper.
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Pesnyakov, V., R. Kharisova e A. Ignatiev. "Absorption properties of bromide photo-thermo-refractive glasses doped with Ytterbium". Journal of Physics: Conference Series 2086, n. 1 (1 dicembre 2021): 012159. http://dx.doi.org/10.1088/1742-6596/2086/1/012159.
Testo completoAbstract (sommario):
Abstract In this work bromide photo-thermo-refractive glasses with different Ytterbium concentration were explored. It is shown that UV irradiation and subsequent heat treatment of samples with Yb 2 mol.% causes significant red-shift absorption line from 410 nm with temperature lower than Tg to 517 nm with temperature Tg +60 °C. For small concentration of Yb (0,1 mol. %) maximum red-shift in plasmon resonance absorption band is shown as 485 nm and it is the same for heat treatment temperatures from Tg +20 °C to Tg +60 °C.
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Kobayashi, T., E. Kanda, K. Kitada, K. Ishiguro e Y. Torigoe. "Detection of Rice Panicle Blast with Multispectral Radiometer and the Potential of Using Airborne Multispectral Scanners". Phytopathology® 91, n. 3 (marzo 2001): 316–23. http://dx.doi.org/10.1094/phyto.2001.91.3.316.
Testo completoAbstract (sommario):
Rice reflectance was measured to determine the spectral regions most sensitive to panicle blast infection. Reflectance increased in the 430- to 530-, 580- to 680-, and 1,480- to 2,000-nm regions at the dough stage both in the laboratory and the field as the percentage of diseased spikelets increased. The wavebands of the greatest sensitivity were in the visible region, located near 485 and 675 nm. After the yellow-ripe growth stage, near-infrared rather than visible reflectance responded to panicle blast infections. Ratios of rice reflectance were evaluated as indicators of panicle blast. R470/R570 (reflectance at 470 nm divided by reflectance at 570 nm), R520/R675, and R570/R675 decreased significantly as the incidence of panicle blast increased at the dough stage. At the yellow-ripe stage, R550/R970 and R725/R900 were used to estimate panicle blast severity as measured in terms of the percentage of diseased spikelets. According to the simulation that uses ground-based sensor data, airborne multispectral scanners may be effective in detecting the occurrence of panicle blast using a band combination of 530- to 570- and 650- to 700-nm regions at the dough stage.
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McKay, Rana R., Xun Lin, Laurence K. Albiges, Andre Poisl Fay, Marina Dusevic Kaymakcalan, Suzanne S. Mickey, Paiman Peter Ghoroghchian et al. "Impact of statins and survival outcomes in patients with metastatic renal cell carcinoma." Journal of Clinical Oncology 33, n. 7_suppl (1 marzo 2015): 435. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.435.
Testo completoAbstract (sommario):
435 Background: A growing body of evidence has demonstrated the antineoplastic activity of statins. The objective of this study was to investigate the impact of statin use on survival in patients with metastatic renal cell carcinoma (mRCC) treated in the modern therapy era. Methods: We conducted a pooled analysis of mRCC patients treated on phase II and III clinical trials. Statistical analyses were performed using Cox regression adjusted for age, sex, race, histology, prior therapy, body-mass index, and other known prognostic factors and the Kaplan-Meier method. Results: We identified 4,736 patients treated with sunitinib (n=1,059), sorafenib (n=772), axitinib (n=896), temsirolimus (n=457), temsirolimus + interferon-alpha (n=208), bevacizumab + temsirolimus (n=393), bevacizumab + interferon-alpha (n=391), or interferon-alpha (n=560), of whom 511 were statin users. Overall, statin users demonstrated a statistically significant improvement in overall survival (OS) but not progression-free survival (PFS) compared to non-users (OS: 25.6 versus 18.9 months; p=0.015; adjusted hazard ratio [aHR] 0.787; 95% CI, 0.648-0.955; PFS: 7.9 versus 6.9 months; p=0.823, aHR 1.018; 95% CI, 0.867-1.196). When stratified by therapy type, a benefit in OS was demonstrated in statin users compared to non-users in individuals receiving therapy targeting vascular endothelial growth factor (28.4 versus 22.2 months, p=0.023; aHR 0.749; 95% CI, 0.584-0.961) or mammalian target of rapamycin (18.6 versus 14.0; p=0.035; aHR 0.657; 95% CI, 0.445-0.972), but not in those receiving interferon-alpha (15.6 versus 14.8 months; p=0.410; aHR 1.292; 95% CI 0.703-2.275). Adverse events were similar between statin users and non-users. Conclusions: In the largest RCC analysis to date, we demonstrate that statin use improved survival outcomes in patients with mRCC treated in the targeted therapy era. Statins could represents a potential adjunct therapeutic option for patients with metastatic RCC; however, this hypothesis needs to be corroborated with preclinical work exploring the mechanisms underlying their anti-cancer effects and well-designed clinical trials investigating the clinical benefits of adding statins to modern therapies.
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Schmidt-Hebbel, J., G. H. Toniollo, F. G. Leite, A. S. Ferraudo, D. Perecin e L. J. Pacola. "Características físicas e morfológicas de sêmen de touros jovens das raças Gir, Guzerá, Nelore (Bos taurus indicus) e Caracu (Bos taurus taurus)". Arquivo Brasileiro de Medicina Veterinária e Zootecnia 52, n. 5 (ottobre 2000): 461–67. http://dx.doi.org/10.1590/s0102-09352000000500010.
Testo completoAbstract (sommario):
Foram utilizados 38 tourinhos com idade inicial entre 426 e 462 dias e final entre 751 e 781 dias das raças Nelore, Guzerá, Gir e Caracu, subdivididos em sete grupos genéticos conforme o método de seleção, com o objetivo de comparar o desenvolvimento reprodutivo, avaliado pelas características físicas e morfológicas do sêmen (volume, aspecto, turbilhonamento, motilidade progressiva e vigor, morfologia e concentração espermáticas), em 11 colheitas com intervalos de 29 dias. Os touros dos grupos Nelore seleção (NeS, n=6), Nelore tradicional (NeT, n=9) e Caracu seleção (CaS, n=6), com 415, 430 e 419kg de peso, respectivamente, apresentaram diferenças em todas as características quando comparados com o Nelore controle (NeC, n=4), com 302kg de peso, na segunda colheita, e este foi o único a diferir dos outros seis grupamentos na décima primeira colheita (P<0,05). Foram registradas diferenças na motilidade progressiva média dos espermatozóides na terceira colheita entre o grupamento CaS (68,3%) e o Guzerá tradicional (GuT, n=5) (10,0%), assim como entre o CaS (76,7%) e o NeS (45,0%) na quarta colheita (P<0,05). Não foram registradas diferenças no total de defeitos de espermatozóides nas segunda e última colheitas. Com base na morfologia espermática pode-se concluir que os tourinhos dos grupos genéticos NeT, CaS, Gir Seleção (GiS, n=4), Guzerá Seleção (GuS, n=4), NeC, GuT e NeS alcançaram a maturidade sexual com idades de 547, 532, 578, 544, 547, 572 e 600 dias, e pesos corporais de 430, 440, 389, 420, 336, 451 e 438kg, respectivamente.
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Heng, Daniel Yick Chin, Connor Wells, Frede Donskov, Brian I. Rini, Jae-Lyun Lee, Georg A. Bjarnason, Benoit Beuselinck et al. "Third-line therapy in metastatic renal cell carcinoma: Results from the International mRCC Database Consortium." Journal of Clinical Oncology 33, n. 7_suppl (1 marzo 2015): 430. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.430.
Testo completoAbstract (sommario):
430 Background: Third-line targeted therapy efficacy in metastatic renal cell carcinoma (mRCC) is not well characterized and many funding bodies do not provide reimbursement for it. Methods: The International mRCC Database Consortium (IMDC) consists of consecutive patient series from 25 cancer centers. It was queried for specific sequences of targeted therapy and third-line therapy. Kaplan Meier estimates were used for survival. Cox proportional hazards models were used to adjust hazard ratios for confounders. Patients that stopped second-line therapy were divided into two groups: those that went onto third-line therapy and those did not. Results: 4,050 patients were treated with first-line targeted therapy, of which 2,011 (49.6%) had second-line therapy and 879 (21.7%) had third-line targeted therapy. The most common third-line therapies were everolimus 25%, sorafenib 14%, sunitinib 13%, temsirolimus 11%, pazopanib 10%, and axitinib 6%. IMDC prognostic groups at third-line therapy initiation were 6% favorable risk, 67% intermediate risk, and 27% poor risk. Overall response rate for third-line therapy was 10.5% and 50.9% had stable disease in those patients that were evaluable. Median PFS was 5.1 months (95% CI, 4.5-5.7) and median OS from third-line therapy initiation was 12.0 months (95% CI, 10.7-12.9). Patients stopping second-line therapy that move on to third-line therapy vs. those that do not receive third line therapy have a median OS from stopping second-line therapy of 13.1 vs. 2.3 mons (p<0.0001). When adjusted for second-line IMDC prognostic criteria and KPS at second-line treatment cessation, patients who do receive third-line therapy have a HR of death of 0.41 (95% CI, 0.32-0.52; p<0.0001) compared to those that do not receive third-line therapy. This may be in part due to patient selection. To further limit bias, when excluding patients that live less than 3 months after second-line therapy cessation, the adjusted HR was similar. Conclusions: Third-line targeted therapy has demonstrated activity and is prevalent in use. Further studies are required to determine appropriate sequencing.
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Tsang, Erica S., Hui-Li Wong, Ying Wang, Daniel John Renouf, Winson Y. Cheung, Howard John Lim, Sharlene Gill, Jonathan M. Loree e Hagen F. Kennecke. "Outcomes and characteristics of patients receiving second-line therapy for advanced pancreatic cancer." Journal of Clinical Oncology 36, n. 4_suppl (1 febbraio 2018): 435. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.435.
Testo completoAbstract (sommario):
435 Background: Recent trials have demonstrated improved outcomes in the 1st-line treatment of advanced pancreatic cancer (APC). However, there is limited randomized data to guide 2nd-line chemotherapy (CT) selection. We aimed to characterize predictors and outcomes of 2nd-line CT in patients (pts) with APC. Methods: We identified all pts with APC (locally advanced (LAPC) or metastatic (MPC)) who received ≥1 cycle of 1st-line CT between January 1, 2012 and December 31, 2015 across 6 centers in British Columbia, Canada. Baseline characteristics and survival outcomes were summarized. Results: Of 676 pts with APC (31% LAPC, 69% MPC) who received ≥1 cycle of CT, 164 (24%) received 2nd-line CT. These pts were younger (median 63.7 vs. 67.4 years; p= 0.01), had a lower ECOG (77% ECOG 0-1 vs. 51% ECOG ≥2; p< 0.001), and higher CA19-9 (median 1034 vs. 829; p= 0.01) compared to patients who did not receive 2nd-line CT. There were no differences in rates of 2nd-line CT between LAPC and MPC (28% vs. 23%; p= 0.18). On logistic regression, only 1st-line FOLFIRINOX (OR 5.90, p< 0.001) was associated with 2nd line CT. CT regimens are summarized by line (Table). Median duration of 2nd-line CT was 3 cycles (range 1-30). Median overall survival (mOS) from diagnosis of patients with 2nd-line CT was 16 months. mOS from 2nd-line CT was longer with 2nd-line gemcitabine/nab-paclitaxel than fluoropyrimidine or gemcitabine (7.9 vs. 5.1 vs. 4.3 months; p= 0.008). On multivariate analysis, longer OS from 2nd-line CT was associated with gemcitabine/nab-paclitaxel (vs. single agent CT), lower ECOG, LAPC (vs MPC), and lower CA 19-9 (HRs 0.49, 0.67, 0.58, 0.38, respectively). Conclusions: In this population-based cohort, pts treated with 2nd line CT were younger, have better ECOG, similar rates of LAPC vs. MPC, and achieved a median OS of 16 months. 1st-line FOLFIRINOX was the strongest predictor of 2nd-line CT. Gemcitabine/nab-paclitaxel was associated with superior 2nd line OS compared to gemcitabine/fluoropyrimidine. [Table: see text]
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Yasaka, Patarawagee, Winut Wongwan, Kitipun Boonin e Jakrapong Kaewkhao. "The Comparative Studies of TeO2: ZnF2: BaO doped Sm2O3 Glass Which Prepare in a Different Atmosphere". Journal of Physics: Conference Series 2602, n. 1 (1 settembre 2023): 012003. http://dx.doi.org/10.1088/1742-6596/2602/1/012003.
Testo completoAbstract (sommario):
Abstract Sm3+ ion doped TeO2: ZnF2: BaO glasses are prepared in different atmospheres by melt quenching technique. The glasses structure was analyzed using a Rigaku SmartLab SE X-ray diffractometer (XRD). Absorption spectra (Shimadzu, 3600) in the wavelength between 400 to 1800 nm were recorded using a UV-VIS-NIR spectrophotometer. They found a total of seven peaks, which corresponded with the energy transitions of Sm3+ ion from the ground level 6H5/2 → 6F11/2, 6F9/2, 6F7/2, 6F5/2, 6F3/2, 6H15/2, and 6F1/2 at 944, 1083, 1238, 1383, 1485 and 1543 nm respectively. A spectrofluorophotometer (Cary-Eclipse) was used to detect the photoluminescence, and the excitation spectra were obtained from measurements in wavelengths of 300 to 550 nm using the emission spectrum at 597 nm. from 6H5/2 (ground state) → 4D7/2 (345), 4D3/2 (362), 6P7/2 (375), 6P3/2 (403), 6P5/2 (417) 4G9/2 (438), 4I13/2 (462) 4I11/2 (474), 4G7/2 (501) and 4F3/2 (526) the excited states. Using a 405 nm exciting wavelength, the emission spectra were captured in the 500–750 nm. The lifetime of the sample between the sample prepared in the air atmosphere and the CO2 atmosphere at the excitation wavelength of 405 nm was 0.679 and 0.662 ms, respectively.
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Aminde, Leopold Ndemnge, Linda J. Cobiac e J. Lennert Veerman. "Potential impact of a modest reduction in salt intake on blood pressure, cardiovascular disease burden and premature mortality: a modelling study". Open Heart 6, n. 1 (febbraio 2019): e000943. http://dx.doi.org/10.1136/openhrt-2018-000943.
Testo completoAbstract (sommario):
ObjectiveTo assess the potential impact of reduction in salt intake on the burden of cardiovascular disease (CVD) and premature mortality in Cameroon.MethodsUsing a multicohort proportional multistate life table model with Markov process, we modelled the impact of WHO’s recommended 30% relative reduction in population-wide sodium intake on the CVD burden for Cameroonian adults alive in 2016. Deterministic and probabilistic sensitivity analyses were conducted and used to quantify uncertainty.ResultsOver the lifetime, incidence is predicted to decrease by 5.2% (95% uncertainty interval (UI) 4.6 to 5.7) for ischaemic heart disease (IHD), 6.6% (95% UI 5.9 to 7.4) for haemorrhagic strokes, 4.8% (95% UI 4.2 to 5.4) for ischaemic strokes and 12.9% (95% UI 12.4 to 13.5) for hypertensive heart disease (HHD). Mortality over the lifetime is projected to reduce by 5.1% (95% UI 4.5 to 5.6) for IHD, by 6.9% (95% UI 6.1 to 7.7) for haemorrhagic stroke, by 4.5% (95% UI 4.0 to 5.1) for ischaemic stroke and by 13.3% (95% UI 12.9 to 13.7) for HHD. About 776 400 (95% UI 712 600 to 841 200) health-adjusted life years could be gained, and life expectancy might increase by 0.23 years and 0.20 years for men and women, respectively. A projected 16.8% change (reduction) between 2016 and 2030 in probability of premature mortality due to CVD would occur if population salt reduction recommended by WHO is attained.ConclusionAchieving the 30% reduction in sodium intake recommended by WHO could considerably decrease the burden of CVD. Targeting blood pressure via decreasing population salt intake could translate in significant reductions in premature CVD mortality in Cameroon by 2030.
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Tiwari, Ashwani Kant, Arun Singh, Tuna Eken e Chandrani Singh. "Seismic anisotropy inferred from direct <i>S</i>-wave-derived splitting measurements and its geodynamic implications beneath southeastern Tibetan Plateau". Solid Earth 8, n. 2 (7 aprile 2017): 435–52. http://dx.doi.org/10.5194/se-8-435-2017.
Testo completoAbstract (sommario):
Abstract. The present study deals with detecting seismic anisotropy parameters beneath southeastern Tibet near Namcha Barwa Mountain using the splitting of direct S waves. We employ the reference station technique to remove the effects of source-side anisotropy. Seismic anisotropy parameters, splitting time delays, and fast polarization directions are estimated through analyses of a total of 501 splitting measurements obtained from direct S waves from 25 earthquakes ( ≥ 5.5 magnitude) that were recorded at 42 stations of the Namcha Barwa seismic network. We observe a large variation in time delays ranging from 0.64 to 1.68 s, but in most cases, it is more than 1 s, which suggests a highly anisotropic lithospheric mantle in the region. A comparison between direct S- and SKS-derived splitting parameters shows a close similarity, although some discrepancies exist where null or negligible anisotropy has been reported earlier using SKS. The seismic stations with hitherto null or negligible anisotropy are now supplemented with new measurements with clear anisotropic signatures. Our analyses indicate a sharp change in lateral variations of fast polarization directions (FPDs) from consistent SSW–ENE or W–E to NW–SE direction at the southeastern edge of Tibet. Comparison of the FPDs with Global Positioning System (GPS) measurements, absolute plate motion (APM) directions, and surface geological features indicates that the observed anisotropy and hence inferred deformation patterns are not only due to asthenospheric dynamics but are a combination of lithospheric deformation and sub-lithospheric (asthenospheric) mantle dynamics. Direct S-wave-based station-averaged splitting measurements with increased back-azimuths tend to fill the coverage gaps left in SKS measurements.
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Duca, Franz, Stefan Aschauer, Caroline Zotter-Tufaro, Christina Binder, Andreas A. Kammerlander, Benedikt Börries, Hermine Agis et al. "Riociguat for the treatment of transthyretin cardiac amyloidosis: data from a named patient use program in Austria". Pulmonary Circulation 9, n. 4 (ottobre 2019): 204589401984939. http://dx.doi.org/10.1177/2045894019849394.
Testo completoAbstract (sommario):
Patients with transthyretin cardiac amyloidosis (TTR CA) suffer from impaired exercise capacity, have a poor quality of life (QoL), and approved treatments are lacking. Stimulators of the soluble guanylate cyclase are promising new pharmaceuticals in the treatment armamentarium of heart failure patients. The aim of the present study was to report on the safety and efficacy of riociguat administration in patients with TTR CA. TTR CA patients received riociguat for 4–6 months within the frames of a national named patient use (NPU) program. Parameters of interest included changes in submaximal exercise capacity, invasive hemodynamic parameters, and QoL. Between March 2012 and June 2017, 86 CA patients were screened for the NPU program, of whom 13 TTR CA patients were eligible for participation. In our study cohort, riociguat had an acceptable tolerability profile. At follow-up, we could detect slight improvements in median 6-min walk distance (396 m [interquartile range (IQR) = 340–518] vs. 400 m [IQR = 350–570], P = 0.045), New York Heart Association class ≥ III (n = 7 [53.9%] vs. n = 0 [0.0%], P = 0.031), cardiac output (4.3 L/min [IQR = 3.9–5.1] vs. 4.5 L/min [IQR = 4.2–5.1], P = 0.022), diastolic pressure gradient (1.0 mmHg [IQR = −1.5–3.0) vs. −1.0 mmHg [IQR = −3.0–1.0], P = 0.049), and QoL (50.0% [IQR = 40.0–58.0] vs. 60.0% [IQR = 50.0–75.0], P = 0.021). Pulmonary arterial pressures were not altered. The present case series of TTR CA patients indicates that riociguat administration was safe and associated with minor clinical as well as hemodynamic improvements.
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Beasley, Malcolm. "BCS: 50 YearsBCS: 50 Years , Edited by Leon N. Cooper and , Dmitri Feldman World Scientific, Hackensack, NJ, 2011. $135.00, $65.00 paper (575 pp.). ISBN 978-981-430-464-1, ISBN 978-981-430-465-8 paper". Physics Today 64, n. 7 (luglio 2011): 53. http://dx.doi.org/10.1063/pt.3.1168.
Testo completo
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Lei, Yidong, Peng Nan, Tashi Tsering, Zhankui Bai e Yang Zhong. "Chemical Composition of the Essential Oils of Two Rhodiola Species from Tibet". Zeitschrift für Naturforschung C 58, n. 3-4 (1 aprile 2003): 161–64. http://dx.doi.org/10.1515/znc-2003-3-402.
Testo completoAbstract (sommario):
The essential oils from rhizomes of Rhodiola crenulata and R. fastigiata in eastern Tibet were analyzed by using GC-MS. The major constituents were geraniol (53.3%), n-octanol (13.4%), 2-methyl-3-buten-2-ol (10.8%), citronellol (5.3%), 3-methyl-2-buten-1-ol (4.0%), myteol (3.0%), and linalool (2.4%) for R. crenulata and geraniol (45.3%), n-octanol (12.3%), 2-methyl-3-buten-2-ol (8.0%), linalool (5.1%), isogeraniol (4.5%), citronellol (4.4%), and cissabinenehydrate (3.6%) for R. fastigiata.
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Jäger, Ralf, Martin Purpura, Jaci Davis, Nikolas Keratsopoulos, Mandy E. Parra, Ariane H. Secrest, Grant M. Tinsley e Lem Taylor. "Glycoprotein Matrix Zinc Exhibits Improved Absorption: A Randomized Crossover Trial". Nutrients 16, n. 7 (30 marzo 2024): 1012. http://dx.doi.org/10.3390/nu16071012.
Testo completoAbstract (sommario):
Biotransformation of minerals via glycosylation by microorganisms such as yeast and/or probiotics yields nutrients bound to a food matrix, resulting in increased bioavailability. The purpose of this study was to compare the effects of glycoprotein matrix-bound zinc (GPM) on absorption compared to inorganic zinc oxide. Sixteen participants ingested 11 mg of zinc as either GPM™ Soy-Free Zinc (GPM, Ashland, Kearny, NJ, USA) or zinc oxide (USP). Blood samples were taken at 0 (i.e., baseline), 30, 60, 90, 120, 180, 240, 300, 360, 420, and 480 min post-ingestion. GPM zinc concentrations were significantly higher at 120 min (p = 0.02; 12.4 ± 5.1 mcg/dL), 180 min (p = 0.002; 16.8 ± 5.1 mcg/dL), and 240 min (p = 0.007; 14.6 ± 5.1 mcg/dL) in comparison to USP zinc oxide. In addition, GPM zinc significantly increased iAUC by 40% (5840 ± 2684 vs. 4183 ± 1132 mcg/dL * 480 min, p = 0.02), and Cmax values were 10% higher in GPM compared to USP (148 ± 21 mcg/dL vs. 135 ± 17.5 mcg/dL, p = 0.08). Tmax was 12% slower in GPM compared to USP (112.5 ± 38.7 min vs. 127.5 ± 43.1 min); however, differences in Tmax failed to reach statistical significance (p = 0.28). Zinc bound to a glycoprotein matrix significantly increased absorption compared to zinc oxide.
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Ohiienko, O. V., S. V. Posmashnyi e T. V. Shvetz. "Investigation of the photoluminescence spectra of rare-earth elements in pores of an opal matrix". Journal of Physics and Electronics 26, n. 2 (26 dicembre 2018): 67–72. http://dx.doi.org/10.15421/331827.
Testo completoAbstract (sommario):
The main idea of this paper is researching the light emission of Eu3+ and Dy3+ in an opal matrix. The opal synthesis was carried out using Stöber method. The size of globules calculated from the transmission spectrum of prepared samples is equal to 231 nm. The samples were infiltrated with rare-earth element oxides in concentrated solution of nitric HNO3 and perchloric HCl acids in the ratio 3:1. Next, the samples were heated to 100°C to reduce the relative content of water. The spectra of photoluminescence in the range 420-640 nm were excited by a semiconductor laser with λ=405 nm at the radiation registration along the direction of growth [111]. In the spectrum of the sample infiltrated by europium, there are distinctive europium lines at 580, 593 and 618 nm, which correspond to the typical transitions of this rare-earth element, such as 5D0→7F0, 5D0→7F1 and 5D0→7F2. Distinctive spectral lines of dysprosium luminescence are at wavelengths of 480 and 572 nm. The maxima of these wavelengths correspond to the typical lines of luminescence of trivalent dysprosium – specifically, transitions 4D9/2→6H13/2 and 4D9/2→6H11/2. The influence of photonic crystalline effects on the photoluminescence spectra of the obtained samples is studied.
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Bayraktar, Funda S., Peter Staron, Mustafa Koçak e Andreas Schreyer. "Analysis of Residual Stress in Laser Welded Aerospace Aluminium T-Joints by Neutron Diffraction and Finite Element Modelling". Materials Science Forum 571-572 (marzo 2008): 355–60. http://dx.doi.org/10.4028/www.scientific.net/msf.571-572.355.
Testo completoAbstract (sommario):
The residual stress distribution in three laser welded T-joint configurations of aerospace aluminium alloys were measured using neutron diffraction and FE-simulation was conducted to compare with the experimental results. A 2 mm thick AA 6013 T6 sheet (as clip) was welded to a 4.5 mm thick and 400 mm wide AA 6156 T4 base plate (as skin of the airframe). In two samples, the thickness of the plate was reduced in some areas after welding to produce so-called “pockets” with the purpose of the weight reduction to resemble the fabrication practise in aircraft industry. The effect of pocketing process, which produced two different geometries around the clip weld on the residual stress evolution was analysed. In the plain sample (without pockets), residual stresses were predicted using the SYSWELD finite element software. The strain measurements on the base plate were performed at three locations; namely, the middle of the weld length (mid-clip), welding start (run-in) and end (run-out) locations. In all welded plates, slightly higher longitudinal tensile residual stresses were detected at the midclip locations, whereas transverse residual stresses were similar for all locations. In the run-out location, higher longitudinal tensile residual stresses were present than in the run-in location, which was the case in our previous results on other samples. The first results of the SYSWELD FE-simulation of the plain sample were compared with experimental results. The comparison has shown particularly good agreement for the transverse stresses. Although the simulation yields higher longitudinal tensile stresses than the experimental results, the stress distributions were very similar.
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Chen, I.-Cherng, e Teng-Ming Chen. "Sol-gel synthesis and the effect of boron addition on the phosphorescent properties of SrAl2O4:Eu2+,Dy3+ phosphors". Journal of Materials Research 16, n. 3 (marzo 2001): 644–51. http://dx.doi.org/10.1557/jmr.2001.0122.
Testo completoAbstract (sommario):
The effects of boron addition on the microstructure and afterglow properties of the long-phosphorescent SrAl2O4:Eu2+,Dy3+ (SAED), synthesized via a novel sol-gel route, were systematically investigated. Significant improvement on luminescence intensity and the lengthening of afterglow persistent time in boron-added SAED (BSAED) phases were observed, as compared to those without boron addition and commercial phosphors. Typical bluish-green emissions attributed to the doublet phosphorescence with wavelengths peaking at 412 and 501 nm for BSAED phase and 398 and 486 nm for the pristine SAED phase were observed. Afterglow with wavelengths peaking at 403 and 485 nm was observed for BSAED phase, whereas that with wavelengths peaking at 486.5 nm was found for the pristine SAED phase, as indicated by time-dependent afterglow decay profiles. Results from scanning electron microscopic morphological studies were used to investigate the modification of microstructure of the BSAED phases.
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Xiao, Qi, e Gao Yuan Zhu. "Photoluminescence Properties of Sm3+-Doped La2O3 Powders". Advanced Materials Research 399-401 (novembre 2011): 967–72. http://dx.doi.org/10.4028/www.scientific.net/amr.399-401.967.
Testo completoAbstract (sommario):
The Sm3+-Doped La2O3powders were prepared by precipitation method. The room temperature photoluminescence (PL) spectra of Sm3+-Doped La2O3powders doped with different Sm3+concentration excited at 405 nm have been investigated. The PL spectra showed three main strong emissions peaks at near 572, 613, and 657 nm, which were due to the f-f forbidden transitions of the 4f electrons of Sm3+, corresponding to4G5/2→6H5/2(572 nm),6H7/2(613 nm), and6H9/2(657 nm), respectively. The optimum Sm3+concentration in La2O3powders for optical emission was determined to be 2.0 %. Since the 2% Sm-doped La2O3 offer a rather strong f–f transition excitation in near the UV region, the as-prepared phosphors are likely to be used as potential red phosphors for near-ultraviolet (370-410 nm) light-emitting diodes (LEDs).
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Hasiak, Mariusz, Marcel Miglierini, Narges Amini e Marek Bujdoš. "Microstructure and magnetic properties of amorphous Fe51Co12Si16B8Mo5P8 alloy". Nukleonika 62, n. 2 (27 giugno 2017): 85–89. http://dx.doi.org/10.1515/nuka-2017-0011.
Testo completoAbstract (sommario):
Abstract Microstructure and thermomagnetic characteristics of the amorphous Fe51Co12Si16B8Mo5P8 alloy in the as-quenched state and after 1 h of annealing at 573 K and 773 K are studied. The structural investigations performed by Mössbauer spectroscopy and X-ray diffractometry confirmed the amorphous structure of the analysed materials. An increase in the annealing temperature up to 773 K does not lead to crystallization of the amorphous alloy. Only structural rearrangement that causes changes in the topological short-range order and annealing out of free volume is observed. This behaviour was confirmed by modifications of the shapes of hyperfine field distributions derived from the corresponding Mössbauer spectra of the investigated alloys. The Curie temperatures of the as-quenched and annealed Fe51Co12Si16B8Mo5P8 alloy at 573 and 773 K are 400, 405 and 421 K, respectively.
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Hartanto, Laili Budi, Maradu Sibarani e Jones Victor Tuapetel. "Analisa Teknis Dan Biaya Penggunaan Bahan Bakar Cangkang Kelapa Sawit Dan Batu Bara Pada Boiler DZL4 Di PT. Lautan Luas Tbk." Jurnal Teknik Mesin ITI 4, n. 1 (27 febbraio 2020): 17. http://dx.doi.org/10.31543/jtm.v4i1.301.
Testo completoAbstract (sommario):
Abstrak Boiler DZL4 dengan tipe solid fuel dioperasikan di PT. Lautan Luas Tbk untuk proses reaksi kimia. Penelitian ini bertujuan untuk menganalisa jumlah kebutuhan dan biaya untuk bahan bakar batu bara jenis bituminus dan cangkang sawit. Variabel bebas adalah kapasitas boiler 2,5 ton/jam, 3 ton/jam, 4 ton/jam. Variabel konstan adalah tekanan steam 1,25 MPa, temperatur steam 194ºC, temperature air umpan 75°C pada tekanan 0,15 MPa, efisiensi boiler 78,8%. Metode penelitian adalah dengan menghitung kebutuhan kalor boiler, kebutuhan bahan bakar, jumlah biaya untuk setiap jenis bahan bakar dilanjutkan dengan analisa. Hasil perhitungan kalor boiler kapasitas 2,5 ton/jam, 3 ton/jam, 4 ton/jam berturut-turut adalah 1.482.476 kkal/jam, 1.778.972 kkal/jam, 2.371.962 kkal/jam. Kebutuhan bahan bakar batu bara dan cangkang sawit per jam berturut-turut sebesar 304 kg, 364 kg, 483 kg dan 430 kg, 511 kg, 681 kg. Biaya untuk batu bara dan cangkang sawit per jam berturut-turut adalah Rp350.000, Rp419.000, Rp555.500, dan Rp365.500, Rp435.500, Rp579.000.Kata kunci: boiler, solid fuel, cangkang sawit, batu bara, biayaAbstract The Boiler DZL4 with solid fuel type are operated in PT. Lautan Luas Tbk for chemical reaction processes. The purpose of this research is to analize the amount of use and costs between palm kernel shell and bituminous type of coal. The independent variables are boiler capacity of 2,5 tons/hour, 3 tons/hour and 4 tons/hour. The constant variable is steam pressure 1,25 MPa, steam temperature 194ºC, feed water temperature 75°C at 0,15 MPa pressure and boiler efficiency 78,8%. The research method is to calculate the boiler heat requirements, amount of fuel needs, the costs for each type of fuel then continue the analysis. The results of heating boiler calculations for capacity of 2,5 tons/hour, 3 tons/hour and 4 tons/hour respectively are 1.482.476 kcal/hour, 1.778.972 kcal/hour, 2.371.962 kcal/hour. The fuel consumption of coal and palm kernel shells per hour respectively are 304 kg, 364kg, 483 kg, and 430 kg, 511 kg, 681 kg. The cost for coal and palm kernel shells per hour respectively are Rp350.000, Rp419.000, Rp555.500, and Rp365.500, Rp435.500, Rp579.000.Keywords: boiler, solid fuel, palm kernel shell, coal, cost
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Sahar, M. R., R. Arifin e S. K. Ghoshal. "Emission Spectra of Zinc Oxychloride Tellurite Glass: Effects of Eu3+/Sm3+ Co-Doping". Solid State Phenomena 181-182 (novembre 2011): 451–54. http://dx.doi.org/10.4028/www.scientific.net/ssp.181-182.451.
Testo completoAbstract (sommario):
Eu3+or/and Sm3+co-doped glasses based on TeO2-ZnO-ZnCl2-Li2O are prepared using the melt quenching technique and the effects of co-doping on the emission spectra of these glasses are examined. The Sm3+doped glass under 403 nm excitations show emission bands around 561, 598 and 642 nm corresponding to the transitions of4G5/2→6H5/2,4G5/2→6H7/2and4G5/2→6H9/2respectively. Whereas, in Eu3+doped glass under 397 nm excitation emission bands appear around 553, 586, 613, 650 and 699 nm that corresponds to the transitions of5D1→7F2,5D0→7F1,5D0→7F2,5D0→7F3and5D0→7F4. In addition, the emission spectra of the Eu3+/Sm3+co-doped glass under 482 nm excitation consists of five bands in which three are contributed by Sm3+at 561, 598 and 642 nm and two by Eu3+at 613 nm and 699 nm respectively. Surprisingly, the emission bands of Eu3+are still observed in the emission spectra of Sm3+for the Eu3+/Sm3+co-doped glasses despite the absence of the excitation wavelength 482 nm in the absorption and excitation domain of Eu3+. This observation is attributed to the partial resonance transfer of the absorption energy from Sm3+to the Eu3+ions.
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González Austria Noguez, Liliana. "La Tumba 3 del Templo XVIII-A de Palenque y su pintura mural". EntreDiversidades. Revista de Ciencias Sociales y Humanidades 21 (13 maggio 2024): 1–21. http://dx.doi.org/10.31644/ed.iei.v21.2024.a02.
Testo completoAbstract (sommario):
La Tumba 3 del Templo XVIII-A de Palenque es el lugar en donde se localizó el entierro primario más antiguo conocido hasta el momento en este sitio arqueológico y, por lo tanto, la fuente más importante para acercarnos a una parte de la historia temprana de esta ciudad. En la cámara fue enterrado un hombre con escoliosis idiopática severa acompañado de una mujer. El hombre tenía restos de cinabrio en su pelvis con fines conservativos y simbólicos. Su ajuar funerario consistía en platos y cuencos rojos y negros del complejo cerámico Motiepa, jades, conchas, una máscara y unas hachuelas de un cinturón ceremonial. Las paredes y las jambas estaban decoradas con un fondo blanco de estuco con figuras en rojo realizadas con cinabrio. Desde el descubrimiento de esta tumba se ha especulado sobre su posible dueño: K’uk B’ahlam (431-435), Ch’a (435-487), B’utz’aj Sak Chiik (487-501) y Ahku’l Mo’ Naahb’ I (501-524), ya que ha sido considerada como el modelo de K’ihnich Janaab’ Pakal para realizar su propio mausoleo en el Templo de las Inscripciones. Pero el enigma continúa ya que recientes pruebas de radiocarbono la ubican antes que todos ellos (250-420 d. C.).
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Pechyen, Chiravoot, Duangdao Aht-Ong, Duangduen Atong e Viboon Sricharoenchaikul. "Physicochemical Properties of Carbons Prepared from Physic Nut Waste by Phosphoric Acid and Potassium Hydroxide Activations". Materials Science Forum 561-565 (ottobre 2007): 1719–22. http://dx.doi.org/10.4028/www.scientific.net/msf.561-565.1719.
Testo completoAbstract (sommario):
Char derived from pyrolysis of physic nut waste at 400-800°C was used for the preparation of activated carbon by chemical impregnation of phosphoric acid and potassium hydroxide. The original char exhibited the BET surface area in the range of 120-250 m2·g-1. The surface area increased to 480 and 532 m2·g-1 when activated with H3PO4 and KOH, respectively. Equilibrium adsorption data was found to be best represented by the Langmuir isotherm with maximum monolayer adsorption capacity of 560.13 mg·g-1 at 30°C. The adsorption capacity of the physic nut residue activated carbon was comparable to commercial activated carbon.
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Balas, Antonio, Miguel A. Moreno‐Hidalgo, Raquel Alenda, Félix García‐Sánchez e José L. Vicario. "Identification of four new HLA alleles, HLA‐B*40:455 , ‐ C*03:521 , ‐ C*03:04:81 and ‐ DQB1*03:431". HLA 96, n. 2 (11 giugno 2020): 219–20. http://dx.doi.org/10.1111/tan.13946.
Testo completo
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VALENÇA, MARCELO MORAES, e LUCIANA PATRÍZIA A. ANDRADE VALENÇA. "Etiologia das crises epilépticas na cidade do Recife, Brasil: estudo de 249 pacientes". Arquivos de Neuro-Psiquiatria 58, n. 4 (dicembre 2000): 1064–72. http://dx.doi.org/10.1590/s0004-282x2000000600014.
Testo completoAbstract (sommario):
Estudamos as causas etiológicas das crises epilépticas apresentadas por 249 pacientes, que procuraram um serviço de neurologia na Cidade do Recife, Brasil. A causa da crise não foi identificada em 43,0% dos pacientes. Como fatores de risco determinantes das crises encontramos: acidente vascular cerebral isquêmico (AVCI ; 17,3%), cisticercose (8,8%), trauma crânio-encefálico (TCE; 6,8%), neoplasias intracranianas (6,8%), AVC hemorrágico (AVCH; 4,8%), malformação vascular cerebral (3,6%) e outras causas (8,4%). Nos pacientes com menos de 15 anos, a causa mais frequente foi cisticercose (10,3%), seguida por malformação vascular (5,1%) e AVCI (5,1%). No grupo com idade entre 15 e 45 anos o fator determinante mais frequente foi cisticercose (11,6%), seguido por TCE (10,7%), AVCI (4,5%) e neoplasia (3,6%). Porém, nos pacientes com mais de 45 anos a principal causa foi AVCI (36,7%), seguido por neoplasia (12,3%), AVCH (11,2%) e cisticercose (5,1%). Concluindo, a doença cerebrovascular foi a causa mais prevalente de crise epiléptica, quando consideramos todas as idades. No entanto, a cisticercose cerebral foi a principal causa encontrada em pacientes com menos de 45 anos.
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Gong, Chun Xia, Oluwatosin Emmanued Bankole e Li Xu Lei. "The Effect of PEG on Performance of Li0.96Na0.04Ni1/3Co1/3Mn1/3O2 as Cathode Material". Key Engineering Materials 575-576 (settembre 2013): 7–10. http://dx.doi.org/10.4028/www.scientific.net/kem.575-576.7.
Testo completoAbstract (sommario):
Li0.96Na0.04Ni1/3Co1/3Mn1/3O2with PEG400 or PEG2000 as additive was synthesized by coprecipitation method. Xray diffraction pattern reveals that both the products with PEG400 and PEG2000 are pure phase. Scanning Electron Microscopy shows that the average sizes of the powders are 100 nm and 80 nm, respectively. The sample with PEG 2000 has initial discharge capacity (205.8 Mah×g1) and the sample with PEG 400 exhibits good cycle performance with the capacity retention of 86.34 % after 90 cycles compared to that has no additive (167.6 mAh.g-1and 71.18 %) in the cut-off voltage of 2.0-4.5 V at 0.1 C rate. Therefore, PEG400 or PEG2000 as additive should improve the performance of Li0.96Na0.04Ni1/3Co1/3Mn1/3O2cathode material.
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Zhou, Jia, Zhidong Qiu, Minghua Duan, Zhe Lin e Xiaowei Huang. "Identification of Cortex Cercis chinensis Decoction Pieces from Different Growth Origins Using Raman Spectroscopy". Journal of Biobased Materials and Bioenergy 18, n. 4 (1 luglio 2024): 667–74. http://dx.doi.org/10.1166/jbmb.2024.2412.
Testo completoAbstract (sommario):
The complexity of traditional Chinese medicine (TCM) components and the time-consuming of traditional detection methods make it necessary and meaningful to establish rapid and efficient identification techniques. This study explores the potential of Raman spectroscopy, a non-destructive technique offering details of molecular structure, for rapid and accurate identification. Cortex Cercis chinensis (CCC) decoction pieces from diverse geographical origins, Anhui, Sichuan, Zhejiang, and Hubei, were collected and analyzed using Raman spectroscopy at 785 nm, and the Raman characteristic peaks were analyzed. MATLAB software was employed to analyze the similarity between the spectra of CCC decoction pieces, and the original Raman spectral data were transformed into first and second derivative spectra. The results revealed distinct Raman spectral characteristics of carbohydrates and glycosidic bonds (characteristic peaks at 480, 531, 549, 873, 946 and 1086 cm−1). The correlation coefficients of the all the four samples from different origins ranged from 0.9625 to 0.9912, while the coincidence coefficients ranged from 0.9602 to 0.9934. The first and second derivative demonstrated significantly different peaks within specific ranges, 180–200, 280–380, and 680–740 cm−1 for first derivatives, 160–300, 340–400 and 420–480 cm−1 for second derivatives. These obvious differences in first and second derivative spectra of Raman spectra of CCC decoction pieces demonstrated the different growth origins. In conclusion, the study demonstrated the ability of Raman spectroscopy to accurately differentiate CCC decoction pieces from different geographical growth origin. These findings provided a basis for further application of Raman spectra characteristic fingerprints to be used in quality control for rapid identification of the quality and origin of TCM raw materials.
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Belozorov, Alexei, Olga Fedets, Tatjana Chastii, Elena Milutina, Oksana Sokol, Ritsa Grigorova e Sergey Unuchko. "Chlamydia trachomatis infection positivity rates determined by nucleic acid amplification test in patients of hospitals in the northeastern region of Ukraine". International Journal of STD & AIDS 28, n. 14 (5 giugno 2017): 1405–9. http://dx.doi.org/10.1177/0956462417709831.
Testo completoAbstract (sommario):
There are no accurate data regarding the prevalence of Chlamydia trachomatis infection in Ukraine. This study aims to estimate the prevalence in the northeastern region of the country through reviewing nucleic acid amplification test results in patients of medical institutions in the Kharkov region during 2014–2016. Samples from 6920 patients (5028 women and 1892 men) aged 12–76 years were tested. The overall positivity rate was 4.5% (95% CI 4.0–5.0): 3.9% (95% CI 3.4–4.5) in women and 6.1% (95% CI 5.1–7.3) in men. The highest prevalence was found in the 16–20 (8.5%, CI 6.3–11.4) and 21–25 (8.0%, CI 6.7–9.4) year age groups. The prevalence in men was higher than in women in all investigated groups. The results show the need for more attention to the prevention, diagnosis, and treatment of chlamydial infection in these age groups of women and men in this region.
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Conard, Jacqueline, Christophe Marzac, Fabrice Juin, Marie-Helene Horellou, Ors’Antone Calendini e Nicole Casadevall. "JAK2 V617F in 3 Patients with Venous Thromboembolism (VTE) Followed during a Long Period of Time." Blood 108, n. 11 (16 novembre 2006): 4092. http://dx.doi.org/10.1182/blood.v108.11.4092.4092.
Testo completoAbstract (sommario):
Abstract Hereditary thrombophilia and myeloproliferative disorders (MPD) are risk factors of VTE. The JAK2 V617F mutation may be found in polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis. We report three women referred to our out-patient clinic for a thrombophilia screening. JAK2 mutation was studied using wild type FRET probes and subsequent analysis of the melting curve (James et al, Leukemia2006; 20: 350–353). Patient 1, 75 year-old (yo), had pulmonary embolism (PE) and proximal deep vein thrombosis (DVT) at 68. We detected heterozygous FV Leiden (FVL) and FII 20210A mutations. In 2005, she had internal jugular vein thrombosis after surgery (platelet count > 600 G/L). ET was suspected in 2006. Patient 2, 44 yo, on oral contraception, had PE and proximal DVT at 33 after sclerotherapy, recurrent massive PE requiring emergency embolectomy and proximal DVT during pregnancy. Heterozygous FVL was detected in 1995 (platelet count was 432 G/L) and ET in 2000. Patient 3, 65 yo, with PV detected in 1995, had a proximal DVT one year later. Heterozygous FVL was detected. She is the only patient treated with hydroxyurea. Results of blood cell counts and JAK2 V617F/JAK2 WT ratios are shown in the table. Conclusion 1. JAK2 mutation was found in 3 patients with VTE, platelet count >400 G/L and hereditary thrombophilia; 2. the risk of VTE related to JAK2 needs further investigation; 3. JAK2 V617F increased over time in 2 of 3 cases; 4. its early detection might improve the diagnosis and treatment of MPD and VTE. Patient Year Platelet (G/L) Hemoglobin (g/dl) Hematocrit (%) Leukocytes (G/L) JAK2 ratio 1 2000 431 15.3 45.9 8.6 10% 2006 448 13.9 43.3 10.4 50% 2 1997 541 14.1 42.6 6.1 25% 2005 796 14.0 42.8 7.4 15% 3 1997 501 14.1 42.6 4.6 15% 2003 609 13.6 42.1 5.8 20% 2006 485 12.8 37.9 4.8 50%
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Koie, Takuya, Hayato Yamamoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto e Chikara Ohyama. "Significance of preoperative butyrylcholinesterase as an independent predictor of overall survival in patients with renal clear cell carcinoma treated with nephrectomy." Journal of Clinical Oncology 32, n. 4_suppl (1 febbraio 2014): 458. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.458.
Testo completoAbstract (sommario):
458 Background: Prognostic factors for overall survival (OS) of the patients with clear cell renal cell carcinoma (cRCC) treated with nephrectomy are still not defined well. Butyrylcholinesterase (BChE) is an α-glycoprotein found in the nervous system and liver. Advanced cancer is a condition with mild to moderate inflammation and interacts with various degree of protein-energy malnutrition. In this study, we analyzed the potential preoperative prognostic significance of BChE in patients with cRCC undergoing nephrectomy. Methods: etween 1992 and 2013, we treated 551 patients with renal cell carcinoma. Of these 400 patients with cRCC who underwent radical or partial nephrectomy were enrolled. Serum BChE was routinely measured before operation in all patients. Covariates included age, gender, performance status (PS), preoperative laboratory data, clinical T stage, and distant metastasis status. Univariate analyses were performed using the Kaplan-Meier and log-rank methods. Multivariate analysis was performed using a Cox proportional hazard model. Univariate and multivariate analyses were performed to determine clinical factors that associated with OS. Results: Of these, 302 patients had an organ-confined disease (T1-2N0M0) and 56 patients had a distant metastasis (any T, any N, and M1). The median BChE level was 250U/L (normal range from 168 to 470U/L). The median follow-up period was 34 months. At the time of analysis, 26 patients (6.5%) had alive with recurrent cRCC and 38 patients (9.5%) had died from cRCC. The 3-year OS rate for our entire cohort of 400 patients was 88%. The 3-year OS rates were 89.3% and 77.7% in the BChE ≥100 and <100U/L groups (p= 0.004). In the univariate analysis, PS, anemia, hypoalbuminemia, BChE, corrected calcium, C-reactive protein, and distant metastasis status were significantly associated with OS. Multivariate analysis revealed that BChE and distant metastasis status were significantly associated with OS. Conclusions: These data suggest a possible role of pre-operative BChE as an independent predictor of OS after nephrectomy for cRCC.
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Wang, H., X. Liu, K. Chance, G. Gonzalez Abad e C. Chan Miller. "Water vapor retrieval from OMI visible spectra". Atmospheric Measurement Techniques Discussions 7, n. 1 (22 gennaio 2014): 541–67. http://dx.doi.org/10.5194/amtd-7-541-2014.
Testo completoAbstract (sommario):
Abstract. There are distinct spectral features of water vapor in the wavelength range covered by the Ozone Monitoring Instrument (OMI) visible channel. Although these features are much weaker than those at longer wavelengths, they can be exploited to retrieve useful information about water vapor. They have an advantage in that their small optical depth leads to fairly simple interpretation as measurements of the total water vapor column density. We have used the Smithsonian Astrophysical Observatory (SAO)'s OMI operational retrieval algorithm to derive the Slant Column Density (SCD) of water vapor from OMI measurements using the 430–480 nm spectral region after extensive optimization of retrieval windows and parameters. The Air Mass Factor (AMF) is calculated using look-up tables of scattering weights and monthly mean water vapor profiles from the GEOS-5 assimilation products. We convert from SCD to Vertical Column Density (VCD) using the AMF and generate associated retrieval averaging kernels and shape factors. Our standard water vapor product has a median SCD of ~ 1.3 × 1023 molecule cm−2 and a median relative uncertainty of ~ 11% in the tropics, about a factor of 2 better than that from a similar OMI algorithm but using narrower retrieval window. The corresponding median VCD is ~ 1.2 × 1023 molecule cm−2. We have also explored the sensitivities to various parameters and compared our results with those from the Moderate-resolution Imaging Spectroradiometer (MODIS) and the Aerosol Robotic NETwork (AERONET).
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Nakayama, T., K. Sato, Y. Matsumi, T. Imamura, A. Yamazaki e A. Uchiyama. "Wavelength and NO<sub>x</sub> dependent complex refractive index of SOAs generated from the photooxidation of toluene". Atmospheric Chemistry and Physics 13, n. 2 (16 gennaio 2013): 531–45. http://dx.doi.org/10.5194/acp-13-531-2013.
Testo completoAbstract (sommario):
Abstract. Recently, secondary organic aerosols (SOAs) generated from anthropogenic volatile organic compounds have been proposed as a possible source of light-absorbing organic compounds, "brown carbon," in the urban atmosphere. However, the atmospheric importance of these SOAs remains unclear due to limited information about their optical properties. In this study, the complex refractive index (RI, m = n-ki values at 405, 532, and 781 nm of the SOAs generated during the photooxidation of toluene (toluene-SOAs) under a variety of initial nitrogen oxide (NOx = NO + NO2) conditions were examined by photoacoustic spectroscopy (PAS) and cavity ring-down spectroscopy (CRDS). The complex RI-values obtained in the present study and reported in the literature indicate that the k-value, which represents the light absorption of the toluene-SOAs, increased to shorter wavelengths at <532 nm, and the n-value also increased to shorter wavelengths from 781 to 355 nm. The k-values at 405 nm were found to increase from 0.0018 to 0.0072 with increasing initial NOx concentration from 109 to 571 ppbv. The nitrate to organics ratio of the SOAs determined using a high-resolution time-of-flight aerosol mass spectrometer (H-ToF-AMS) also increased with increasing initial NOx concentration. The RI-values of the SOAs generated during the photooxidation of 1,3,5-trimethylbenzene in the presence of NOx (1,3,5-TMB-SOAs) were also determined to investigate the influence of the chemical structure of the precursor on the optical properties of the SOAs, and it was found that the light absorption of the 1,3,5-TMB-SOAs is negligible at all of the wavelengths investigated (405, 532, and 781 nm). These results can be reasonably explained by the hypothesis that nitroaromatic compounds, such as nitrocresols, are the major contributors to the light absorption of the toluene-SOAs. Using the obtained RI-values, mass absorption cross sections of the toluene-SOAs at 405 nm were estimated to be 0.08–0.52 m2g−1 under typical conditions in an urban atmosphere during the daytime. These results indicate that light absorption by the SOAs potentially contributes to the radiation balance at ultraviolet wavelengths below ~400 nm, specifically when the mass concentrations of the anthropogenic SOAs are significant compared with other light-absorbing particles.
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Voskanyan, S. E., A. I. Artemiev, E. V. Naydenov, Ilya Yurievich Kolyshev, D. A. Zabezhinsky, M. V. Shabalin, A. N. Bashkov, O. O. Grigorieva, V. V. Shcherbin e A. S. Zhurbin. "ALPPS in overcoming small remnant liver volume in alveolar echinococcosis". Annaly khirurgicheskoy gepatologii = Annals of HPB surgery 23, n. 4 (23 gennaio 2019): 21–32. http://dx.doi.org/10.16931/1995-5464.2018421-32.
Testo completoAbstract (sommario):
Aim.To evaluate the possibilities and indications for ALPPS, immediate and long-term results of surgical treatment of alveolar echinococcosis including great vessels invasion in case of small remnant liver volume.Material and methods. There were 30 ALPPS procedures. Seven patients had small future liver remnant (FLR) — 24.5% (22.4—26.7%). Bile ducts repair with Roux-en-Y procedure for biliodigestive anastomosis during the first surgical stage was performed in 5 patients (71.4%). ALPPS combined with great vessels resection (portal vein or portal vein and left hepatic vein) was required in 4 patients (57.1%). RO-resections were carried out in all patients.Results.Mean duration of ALPPS stage I was 365 (330—415) min, intraoperative blood loss — 800 (700—1000) ml. Time of stage II was 85 (70—110) min, intraoperative blood loss — 200 (100—300) ml. The second stage of ALPPS was performed in 6—7 days (max 8 days) after preliminary assessment of FLR volume according to CT-volumetry, which was 570 (430—630) ml (37.9% (31.9—52.4%) in relation to FLR volume before the first stage of ALPPS. Augmentation of FLR volume was 200 (150—290) ml (60.9% (48.3—80.6%)). The daily increase of FLR volume was 29 (23—46) ml. Overall postoperative morbidity was 42.9% (complications grade I were noted in 2 patients (28.6%), grade IV — in 1 patient (14.3%). Incidence of post-hepatectomy liver failure grade A (ISGLS, 2011) after ALPPS stage II was 42.9% (n = 3). Bile leakage grade A (ISGLS, 2011) occurred in 28.6% of cases (n = 2). Mortality was absent. Postoperative hospital-stay after stage II was 22 (18—35) days. Maximum follow-up was 50 months. Long-term disease-free survival was 100%, median survival — 29 months.Conclusion.ALPPS technique is feasible, followed by desired increase of FLR volume and safe hepatectomy. The procedure leads to good immediate and long-term postoperative results in patients with alveolar echinococcosis and small FLR volume regard less invasion of afferent and/or efferent liver vessels.
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YOKOYA, AKINARI, RITSUKO WATANABE e TAKEHIRO HARA. "Single- and Double-Strand Breaks in Solid pBR322 DNA Induced by Ultrasoft X-rays at Photon Energies of 388, 435 and 573 eV". Journal of Radiation Research 40, n. 2 (1999): 145–58. http://dx.doi.org/10.1269/jrr.40.145.
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Groen, Harry J. M., Hannie Sietsma, Andrew Vincent, Monique M. H. Hochstenbag, John W. G. van Putten, Anke van den Berg, Otilia Dalesio et al. "Randomized, Placebo-Controlled Phase III Study of Docetaxel Plus Carboplatin With Celecoxib and Cyclooxygenase-2 Expression As a Biomarker for Patients With Advanced Non–Small-Cell Lung Cancer: The NVALT-4 Study". Journal of Clinical Oncology 29, n. 32 (10 novembre 2011): 4320–26. http://dx.doi.org/10.1200/jco.2011.35.5214.
Testo completoAbstract (sommario):
Purpose Cyclooxygenase-2 (COX-2) protein expression in patients with non–small-cell lung cancer (NSCLC) may be not only a prognostic marker but also predictive for COX-2 inhibition. We hypothesized that COX-2 expression is associated with shorter survival and that celecoxib, being a potent COX-2 inhibitor, increases tumor response and survival. Patients and Methods A phase III study was performed in patients with stage IIIb/IV NSCLC who had pathologic confirmation, no prior chemotherapy, Eastern Cooperative Oncology Group performance status of 0 to 2, and adequate organ function. Treatment consisted of docetaxel and carboplatin every 3 weeks for five cycles. Patients were randomly assigned to receive celecoxib 400 mg or placebo twice daily. COX-2 expression on tumor cells was detected by immunohistochemistry. Primary end point was overall survival (OS). Results From July 2003 to December 2007, 561 patients were randomly assigned. Toxicity was mild, and no increase in cardiovascular events was observed. Tumor response was 38% in the celecoxib arm and 30% in the placebo arm (P = .08). Median progression-free survival was 4.5 months (95% CI, 4.0 to 4.8) for the celecoxib arm and 4.0 months (95% CI, 3.6 to 4.9) for the placebo arm (hazard ratio [HR], 0.8; 95% CI, 0.6 to 1.1; P = .25). Median OS was 8.2 months (95% CI, 7.5 to 8.8) for both treatment arms (HR, 0.9; 95% CI, 0.6 to 1.2; P = .32). COX-2 expression did not independently predict survival. Benefit from celecoxib, restricted to patients with low COX-2 expression, was not significant when adjusted for prognostic factors. Conclusion In advanced NSCLC, celecoxib does not improve survival. In this study, COX-2 expression was not a prognostic biomarker and had no predictive value when celecoxib was added to chemotherapy.
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Oliveira, Luiz Antonio de, e Hélio Paracaima de Magalhães. "Quantitative evaluation of acidity tolerance of root nodule bacteria". Revista de Microbiologia 30, n. 3 (luglio 1999): 203–8. http://dx.doi.org/10.1590/s0001-37141999000300004.
Testo completoAbstract (sommario):
Quantification of acidity tolerance in the laboratory may be the first step in rhizobial strain selection for the Amazon region. The present method evaluated rhizobia in Petri dishes with YMA medium at pH 6.5 (control) and 4.5, using scores of 1.0 (sensitive, "no visible" growth) to 4.0 (tolerant, maximum growth). Growth evaluations were done at 6, 9, 12, 15 and 18 day periods. This method permits preliminary selection of root nodule bacteria from Amazonian soils with statistical precision. Among the 31 rhizobia strains initially tested, the INPA strains 048, 078, and 671 presented scores of 4.0 at both pHs after 9 days of growth. Strain analyses using a less rigorous criterion (growth scores higher than 3.0) included in this highly tolerant group the INPA strains 511, 565, 576, 632, 649, and 658, which grew on the most diluted zone (zone 4) after 9 days. Tolerant strains still must be tested for nitrogen fixation effectiveness, competitiveness for nodule sites, and soil persistence before their recommendation as inoculants.
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Giang, N. T. N., N. D. Tan, T. V. Khai e V. T. X. Tuyen. "Effect of initial total soluble solids and pH on the quality of fermented beverage from green asparagus roots (Asparagus officinalis L.)". Food Research 8, n. 3 (20 giugno 2024): 460–68. http://dx.doi.org/10.26656/fr.2017.8(3).570.
Testo completoAbstract (sommario):
Green asparagus (Asparagus officinalis L.) root was used as raw materials for the new fermented beverage because of its nutrition. With the goal of improving the value of green asparagus and contributing to the diversification of asparagus products; the fermented beverage (light alcoholic beverage) was the target of the research. The fermentation was conducted with 2 factors including initial total soluble solids (18-24°Bx) and pH (4.0-5.5). The results showed that the suitable conditions for fermenting the beverage from green asparagus root were 20°Bx and pH 4.5. The ethanol content, the contents of bioactive compounds (phenolic, flavonoid, tannin and saponin) and vitamin C (per 100 g of dry matter) of the fermented beverage from green asparagus were 5.0% v/v, 2.242 g tannic acid equivalent (TAE), 0.206 g quercetin equivalent (QE), 0.273 g TAE, 1.454 g saponin equivalent (SE) and 3.214 g, respectively.
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Bernier, M., M. J. Curtis e D. J. Hearse. "Ischemia-induced and reperfusion-induced arrhythmias: importance of heart rate". American Journal of Physiology-Heart and Circulatory Physiology 256, n. 1 (1 gennaio 1989): H21—H31. http://dx.doi.org/10.1152/ajpheart.1989.256.1.h21.
Testo completoAbstract (sommario):
The relationship between heart rate and ischemia-induced and reperfusion-induced arrhythmias was studied using 573 isolated rat hearts. Hearts (12/group), subjected to 7 min of coronary occlusion and 10 min reperfusion, were paced at 300, 330, 360, 390, 420, 480, or 540 beats/min. Pacing either throughout the experiment or during ischemia alone led to a rate-dependent increase in the incidence of reperfusion-induced ventricular fibrillation (VF) from 25% in the unpaced hearts to greater than 90% when the rate was 420 beats/min or higher. However, pacing during reperfusion alone did not increase the incidence of reperfusion-induced VF. In separate hearts, the right atrium was removed to permit examination of both low and high rates (167 +/- 2, 240, 336 +/- 3, or 480 beats/min throughout the experiment) over a wide range of durations of occlusion (3, 5, 7, 10, 15, 20, or 40 min). Ischemia-induced VF incidence was critically dependent on heart rate, low rates being protective. During reperfusion, the incidence of VF was also highly rate dependent if reperfusion was initiated within 10 min of the onset of ischemia (ranging from 8% when rate was 167 +/- 2 beats/min to 100% when rate was 480 beats/min) but was unrelated to heart rate when reperfusion occurred at later times (ranging from 33 to 50% when ischemia duration was 40 min). Heart rate can therefore influence susceptibility to ischemia- and reperfusion-induced arrhythmias, probably as a result of an effect on the rate of development of ischemic injury.