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Articoli di riviste sul tema "571.430 485"
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Abdellaoui, K., I. Z. Hager, Hosam A. Othman, A. Boumaza e Najoua Kamoun. "Structural, Optical and Thermal Characterizations of Lithium Borate Glasses Containing the Barite". Defect and Diffusion Forum 397 (settembre 2019): 24–38. http://dx.doi.org/10.4028/www.scientific.net/ddf.397.24.
Testo completoAbstract (sommario):
A glass system was prepared according to the formula 60mol%B2O3 – x mol %barite – (40-x) mol %Li2O, where x=0, 5, 7.5, 10, 15 and 20 mol%. The amorphous nature of the prepared glasses was confirmed through X-ray diffraction. The prepared glasses were also characterized by FTIR spectroscopy, UV-vis absorption spectroscopy and the differential thermal analysis (DTA). The density is found to increase and this is because of the higher molecular of the added barite. The molar volume also increases with increasing barite content that indicates the structural changes occurred in borate network that were also confirmed using FTIR. Increasing the concentration of barite shifts the UV cutoff edge toward higher wavelengths from about 300 nm at 0 mol% barite to about 400 nm at 15 mol% of barite. Glass transition temperature (Tg) is found to increase with the increasing barite content. When analyzed by photoluminescence, the samples exhibit luminescence emission centered at around 400, 415, 480, 430, 485, 520, 545, and 570 nm when excited at 300 nm wavelength. The emission peaks at 420 nm, and 440 nm were assigned to F center emission. Between 440 nm and 520 nm it is rather the effect of the presence of the impurities.
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Piechocka-Kłos, Maria. "Wróżbiarstwo i praktyki magiczne w świetle dokumentów wczesnochrześcijańskich synodów oraz ustaw państwowych pierwszych cesarzy chrześcijańskich (IV-VI w.)". Studia Warmińskie 57 (31 dicembre 2020): 361–82. http://dx.doi.org/10.31648/sw.5340.
Testo completoAbstract (sommario):
Chrześcijanie późnego antyku, mimo rosnącej roli chrześcijaństwa i uznania go za religię państwową, żyli w świecie, który nadal obfitował w różnorodne formy kultu pogańskiego. Pogańskie wróżbiarstwo i liczne praktyki magiczne wciąż miały doskonałe warunki do rozwoju. Kulturowa i religijna działalność człowieka, mimo zakazów państwowych i kościelnych, w naturalny sposób utrzymywała potrzebę podejmowania prób, za pomocą specjalnych środków i technik, poznania przyszłości lub wpłynięcia na los i przebieg wydarzeń. Takiej sytuacji sprzyjał fakt, że chrześcijanie nie żyli w izolacji, lecz współegzystowali z poganami na terenie Imperium Romanum. W niniejszej publikacji przedstawiono szczegółową analizę postanowień synodów obradujących od IV do VI w. w odniesieniu do wróżbiarstwa i praktyk magicznych. Analizie w tej kwestii poddano m.in. kanony ogłoszone w Elwirze (306), Arles (314), Laodycei we Frygii (koniec IV w.), Saliq w Seleucji-Ktezyfonie (410), Irlandii (456–465), Vannes w Bretanii (461–491), Galii (ok. 475–485), Agde (506), Orleanie (511), Eleuze (551) dwa razy ponownie w Seleucji-Ktezyfonie (544 i 554) oraz w Bradze (572) i Narbon (589). W celu pełniejszego ukazania przywołanego w temacie zagadnienia omówiono również prawodawstwo cesarskie, ogłaszane w sprawach religijnych przez pierwszych chrześcijańskich cesarzy rzymskich, począwszy od Konstantyna aż do Arkadiusza. Analizie poddano przede wszystkim ustawy zawarte w 16 księdze Kodeksu Teodozjańskiego. W tym kontekście przywołano edykty cesarskie ogłoszone w latach 341, 381, 385, 392, 395 oraz 396.
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Craig, J. B. "Electrochemical oxygen technology Kim Kinoshita, Wiley, Chichester, 1992. Pages ix + 431. £105.00 ISBN 0-471-570-435." Talanta 40, n. 9 (settembre 1993): 1475. http://dx.doi.org/10.1016/0039-9140(93)80233-h.
Testo completo
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Krupa, Michał. "Notki recenzyjne". Z Badań nad Książką i Księgozbiorami Historycznymi 10 (11 dicembre 2019): 397–410. http://dx.doi.org/10.33077/uw.25448730.zbkh.2016.131.
Testo completoAbstract (sommario):
Pamiętniki i relacje w zbiorach rękopiśmiennych BN (wydanie drugie poprawione i rozszerzone), oprac. Danuta Kamolowa przy współudziale Teresy Sieniateckiej, Warszawa: Biblioteka Narodowa, 2015, 539, [1] s., [26] k. tabl.: il., ISBN 978-83-7009-623-6 – Katarzyna Seroka [397-398]
Anna Kocot, Artyści „czarnej sztuki”. Typografia druków Floriana Unglera i Macieja Wirzbięty, Kraków: Księgarnia Akademicka, 2015, ss. 416, ISBN/ISSN 978-83-76384-60-3 – Anna Kamler [398-403]
Justyna Kiliańczyk-Zięba, Sygnety drukarskie w Rzeczypospolitej XVI wieku: źródła ikonografi czne i treści ideowe, Kraków: Wydawnictwo Towarzystwa Naukowego „SocietasVistulana”, 2015, ss. 342, [1]: il., ISBN 978-83-61033-89-9 – Katarzyna Seroka [403-405]
Catalogue of books from the Library of Sigismund II Augustus, King of Poland, in the collection of the National Library of Russia in Saint Petersburg, ed. by Maria I. Tkachenko, Maria Brynda, National Library of Poland (Warsaw), National Library of Russia (Saint Petersburg),Warsaw: National Library of Poland, 2015, 198 [1] s., [21] s. tabl., ISBN 978-83-7009-621-2 – Karolina Figaszewska [405-406]
Joanna Matyasik, Polonika XVI-XVII w. ze zbiorów Wojewódzkiej i Miejskiej Biblioteki Publicznej w Bydgoszczy. Katalog, Bydgoszcz: Wojewódzka i Miejska Biblioteka Publiczna im. Dr. Witolda Bełzy, 2015, ss. 345, ISBN 978-83-85979-21-0; 978-83-62545-86-5 – Agnieszka Chamera-Nowak [406-409]
Polski wkład w przyrodoznawstwo i technikę: słownik polskich i związanych z Polską odkrywców, wynalazców oraz pionierów nauk matematycznoprzyrodniczych i techniki, t. 1-4, red. nauk. Bolesław Orłowski, Warszawa: Instytut Historii Nauki im. Ludwika i Aleksandra Birkenmajerów Polskiej Akademii Nauk, Instytut Pamięci Narodowej – Komisja Ścigania Zbrodni przeciwko Narodowi Polskiemu, 2015, t. 1 ss. 521, t. 2 ss. 437, t. 3 ss. 511, t. 4 ss. 543, ISBN 978-83-8606-229-4; 978-83-8606-228-7; 978-83-7629-829-0; 978-83-7629-828-3; 978-83-7545-569-4; 978-83-7545-570-0 – Sarah Skumanov [409-410]
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Wu, Ming, Fang Long, Hao Ran Geng e Fang Yang. "Effects of Heat Treatment on Microstructure and Properties of AZ91D Magnesium Alloy". Key Engineering Materials 575-576 (settembre 2013): 410–13. http://dx.doi.org/10.4028/www.scientific.net/kem.575-576.410.
Testo completoAbstract (sommario):
The microstructure, hardness and corrosion resistance of AZ91D alloy were investigated under different solution treatments and artificial aging conditions.When ascast AZ91D alloy was heat treated at 415°C by solution treatmentfor 12 h and artificially aged at 200°C, the volume fraction of precipitates increased with the aging time up to 10 h.When ascast AZ91D alloy was treated at 430°C by solution treatment for 12 h and artificially aged at 200°C for 10h, the volume fraction of precipitates reached a peak value.The results of the corrosion test showed that a high corrosion resisting of the second phase precipitates was beneficial to improving the strength and hardness. Solution treatment at 445°C temperature for 12 h destroied the consecutiveness of β-Mg17Al12 phases.
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Juknevičienė, Renata, Justas Simonavičius, Aurimas Mikalauskas, Kamilė Čerlinskaitė-Bajorė, Mattia Arrigo, Vytautas Juknevičius, Irina Alitoit-Marrote et al. "Soluble CD146 in the detection and grading of intravascular and tissue congestion in patients with acute dyspnoea: analysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort". BMJ Open 12, n. 9 (settembre 2022): e061611. http://dx.doi.org/10.1136/bmjopen-2022-061611.
Testo completoAbstract (sommario):
ObjectivesTo evaluate the potential of soluble cluster of differentiation 146 (sCD146) in the detection and grading of congestion in patients with acute dyspnoea.DesignSubanalysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort.SettingTwo Lithuanian university centres.ParticipantsAdult patients with acute dyspnoea admitted to the emergency department.MethodsCongestion was assessed using clinical and sonographic parameters. All patients underwent sCD146 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing.ResultsThe median value of sCD146 concentration in the study cohort (n=437) was 405 (IQR 315–509) ng/mL. sCD146 was higher in patients with peripheral oedema than in those without (median (IQR) 472 (373–535) vs 400 (304–501) ng/mL, p=0.009) and with pulmonary rales than in those without (439 (335–528) vs 394 (296–484) ng/mL, p=0.001). We found a parallel increase of estimated right atrial pressure (eRAP) and sCD146 concentration: sCD146 was 337 (300–425), 404 (290–489) and 477 (363–572) ng/mL in patients with normal, moderately elevated and high eRAP, respectively (p=0.001). In patients with low NT-proBNP, high sCD146 distinguished a subgroup with a higher prevalence of oedema as compared with patients with low levels of both biomarkers (76.0% vs 41.0%, p=0.010). Moreover, high sCD146 indicated a higher prevalence of elevated eRAP, irrespective of NT-proBNP concentration (p<0.05).ConclusionsCD146 concentration reflects the degree of intravascular and tissue congestion assessed by clinical and echocardiographic indices, with this association maintained in patients with low NT-proBNP. Our data support the notion that NT-proBNP might represent heart stretch while sCD146 rather represents peripheral venous congestion.
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Putiš, Marián, Peter Ivan, Milan Kohút, Ján Spišiak, Pavol Siman, Martin Radvanec, Pavel Uher et al. "Meta-igneous rocks of the West-Carpathian basement, Slovakia: indicators of Early Paleozoic extension and shortening events". Bulletin de la Société Géologique de France 180, n. 6 (1 ottobre 2009): 461–71. http://dx.doi.org/10.2113/gssgfbull.180.6.461.
Testo completoAbstract (sommario):
Abstract The paper reviews the main West-Carpathian Early Paleozoic metamorphosed originally sedimentary-magmatic complexes, dated by SHRIMP on zircons, as indicators of crustal extension and shortening events. Igneous precursors of a Layered Amphibolite Complex (LAC) – fractionated upper mantle gabbros to diorites, dated at 503 ± 4 and 492 ± 4 Ma from the North-Veporic, or 480 ± 5 and 450 ± 6 Ma from the Tatric basement are contemporaneous with subaluminous to metaluminous I-type (507 ± 4 Ma, the South-Veporic basement), peraluminous S-type (497 ± 4 Ma, the South-Veporic basement; 516 ± 7, 485 ± 6 and 462 ± 6 Ma, the North-Veporic basement; 497 ± 6, 472 ± 6 and 450 ± 6 Ma, the Tatric basement), alkaline A-type (511 ± 6 Ma, South-Veporic basement) granitic orthogneisses and calcalkaline rhyolitic (482 ± 6 Ma) and dacitic (476 ± 7 Ma) metavolcanics (Gemeric basement), indicating a magmatic immature back arc setting. The ages point to Middle/Late Cambrian, Early and Late Ordovician magmatic phases, coeval with the extension in the northern Gondwana margin. Separation of an inferred Avalonian and/or Galatian terranes distal continental ribbon corresponds with the opening of a Medio-European Basin. A 430-390 Ma dated MP/HP metamorphic event, recorded in the LAC and associated orthogneisses, occurred in the area of thinned immature back arc basin crust due to closure of the Medio-European Basin. Thus a distal Gondwana continental ribbon north of this basin could be an eastward lateral pendant of Armorica, derived from Galatian terrane. Metaophiolites of the Pernek Group (a metagabbrodolerite dated at 371 ± 4 Ma) in the Tatric basement, analogous to island-arc tholeiites and back-arc basin basalts, indicate a back-arc basin setting north of a 430-390 Ma old northward dipping subduction/collision zone, dividing the northward drifting western Galatian terrane microplate from the Gondwana margin. Some metabasites of the Gemeric basement might indicate Late Devonian to Mississippian opening of a peri-Gondwanan Paleotethyan oceanic basin: a 383 ± 3 Ma old remelted metagabbro (482 ± 9 Ma) from the Klátov gneiss-amphibolite complex, ca. 385 Ma old porphyritic metabasite of the Zlatník ophiolite complex, as well as a 350 ± 5 Ma old HP metabasite as tectonic fragment within the Rakovec Group. The closure of Devonian-Mississippian basins, accompanied by medium-pressure (the Pernek Group) to high-pressure (blueschist to eclogitic tectonic fragments in greenschist facies rocks of the Rakovec Group) metamorphism, occurred in late Carboniferous to early Permian, when Paleotethyan realm complexes accreted to a Galatian terrane microplate, the latter represented by the older and the higher-grade Tatric and Veporic basement complexes.
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Ziogas, Dimitrios, Kiruthikah Thillai, Ippokratis Korantzis, MH Ruhe Chowdhury, Dionysios Papadatos-Pastos, Abid Suddle, John O'Grady, Nigel Heaton, Paul J. Ross e Debashis Sarker. "Outcomes and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma (HCC)." Journal of Clinical Oncology 33, n. 3_suppl (20 gennaio 2015): 435. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.435.
Testo completoAbstract (sommario):
435 Background: HCC is the third commonest malignancy worldwide, with the highest incidence rates in patients over 75 years of age. Although sorafenib is used for patients with advanced HCC, there are concerns about the outcomes and tolerability in this age group. Methods: We conducted a retrospective study of 190 patients treated with sorafenib (177 with sorafenib alone, 17 patients with a combination of sorafenib and erlotinib/placebo within the SEARCH trial). Patient demographics and outcomes were recorded. Results: 190 patients were identified with a median age of 66 (26-87). 151 patients were <75 years old (yrs) and 39 patients were >75. 157 patients were male and 33 female. Underlying liver disease in the over 75 group were: non-alcoholic fatty liver disease (N=14, 35.9%), unknown aetiology (N=14, 35.9%), alcoholic liver disease (N=7, 17.9%), hepatitis C (N=2, 5.1%), hepatitis B (N=1, 2.56%,) and autoimmune hepatitis (N=1, 2.56%). 33 patients were Child-Pugh A status when starting sorafenib (A5=25, A6=8) and 6 patients were Child-Pugh B (B7=5, B8=1). There was no statistically significant difference in OS between patients over the age of 75 and younger (7.1m for >75 yrs and 10.4 <75 yrs p=0.360), or in PFS (4.2m vs. 6.8m [p=0.539]). There was also no increase in G3/4 toxicities between both groups of patients with comparable incidences of G3/4 diarrhoea (4.7% <75 vs. 2.6% ≤75 p=0.481), skin toxicity (6.6% vs. 5.1% p=0.537), fatigue (7.3% vs. 7.7% p =0.58) and deteriorating liver function (2.6% vs. 7.3% p = 0.25). There was no difference between the incidence of dose reductions or interruptions (34% vs. 35.9% p=0.5). Conclusions: Our study suggests that patients aged 75 or older appear to tolerate treatment with sorafenib well with comparable toxicities to those less than 75. We also found no significant differences in survival. With an aging population and increasing incidences of HCC, further prospective evidence is needed to identify safety and survival outcomes in this important group of patients.
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Kubáň, Vlastimil, Josef Hedbávný, Irena Jančářová e Milan Vrchlabský. "Spectrophotometric investigation of interactions of sulfophthalein dyes with surfactants". Collection of Czechoslovak Chemical Communications 54, n. 3 (1989): 622–32. http://dx.doi.org/10.1135/cccc19890622.
Testo completoAbstract (sommario):
The effect of cationic (hexadecylpyridinium bromide, hexadecyltrimethylammonium bromide, Septonex), anionic (sodium dodecyl sulfate) and nonionic (Brij 35, Triton X-100) surfactants on the deprotonation of the phenolic oxygen in bromophenol red, bromophenol blue and bromocresol green is studied. The conditional dissociation constants Kai* depend on the surfactant concentration and, in the alkylpyridinium surfactant series, on the alkyl chain length at a constant concentration of inert electrolyte, and on the concentration of the inert electrolyte (Cl-, Br-, NO3-, SO42-, H2PO4-, CH3COO-, HCOO-, ClO4-) or of the sulfophthalein dye at a constant concentration of a cationic surfactant. In acid and alkaline solutions, cationic surfactants (tensides, T) and the dyes (H2L) form ionic associates with the stoichiometric composition {T+, LH-} and {T2+, L2-}, respectively, exhibiting absorption maxima at 400-430 nm (ε = 1.3-2.0 m2 mmol-1) and at 570-630 nm (ε = 3.5-4.5 m2 mmol-1), respectively, formation of these associates was confirmed for chloroform extracts by the continuous variations and molar ratios methods.
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Zhu, Xinhua, Yong Zhou, Yuzi Zhang e Shangli Cai. "Genomic somatic alterations of human epidermal growth factor-2 (HER2) gene: A pan-cancer analysis." Journal of Clinical Oncology 37, n. 15_suppl (20 maggio 2019): 3112. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3112.
Testo completoAbstract (sommario):
3112 Background: Human epidermal growth receptor 2 (HER2) is a well-known oncogenic drive gene with multiple targeted therapeutic options. In this study, we aim to assess the landscape of HER2 alterations in solid tumors and evaluate the feasibility of circulating tumor DNA (ctDNA) tested by next-generation sequence (NGS) as a tool to detect HER2 alterations. Methods: Alterations of HER2 by NGS (Illumina NextSeq 500) were queried in 3D Medicines database. The mean depth of tissue and circulating tumor DNA (ctDNA) test was 500X and 5000X, respectively. 11,013 patients tested using tumor tissue and 6,970 patients tested using ctDNA were included in this analysis. Results: Of 11,013 patients tested using tumor tissue, any HER2 and known or likely deleterious HER2 mutations were identified in 739 (6.7%) and 531 (4.8%) patients, respectively. Of 531 patients who carried known or likely deleterious HER2 mutations, 263 (49.5%) had HER2 amplification and 259 (48.8%) had single nucleotide variations (SNVs). Across all tumor types, breast cancer was found to have the highest frequency of HER2 amplification (14.9%, 48/323), followed by gastric cancer (6.6%, 31/470) and biliary tract cancer (5.8%, 33/571). Moreover, 11% (8/73) of duodenal cancer, 4.5% (7/154) of urothelial cancer, 3.8% (18/470) of gastric cancer, 3.1% (142/4555) of lung cancer, 2.9% (17/571) of biliary tract cancer, 2.8% (44/1562) of colorectal cancer and 2.7% (9/323) of breast cancer carried known or likely deleterious HER2 SNVs. Of 6970 patients tested using ctDNA, any HER2 and known or likely deleterious HER2 mutations were identified in 592 (8.5%) and 277 (4.0%) patients, respectively. In the ctDNA cohort, 15.7% (36/230) of breast cancer and 3.1% (5/161) of biliary tract cancer carried HER2 amplification. However, 11.6% (20/173) of gastric cancer had HER2 amplification tested by ctDNA which was higher than that tested using tissue. Furthermore, 5.6% (13/230) of breast cancer, 4.5% (2/44) of urothelial cancer, 3.4% (6/173), 2.5% of biliary tract cancer and 2.0% (94/4586) lung cancer harbored known or likely deleterious HER2 SNVs in ctDNA cohort. Conclusions: HER2 alterations existed across tumor types and the landscape of genomic alterations in HER2 gene varied according to different type of tumor. In addition, ctDNA can be used as a potential tool to detect HER2 alterations.
Tesi sul tema "571.430 485"
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Hussein, Fadi. "Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2". Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-AD01-A.
Testo completoLibri sul tema "571.430 485"
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Yūsuf, Irshīd. Salājiqat al-Shām wa-al-Jazīrah: Fī al-fatrah mā bayna 435-570 H. [Amman: s.n.], 1988.
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Yūsuf, Irshīd. Salājiqat al-Shām wa-al-Jazīrah: Fī al-fatrah mā bayna 435-570 H. [Amman: s.n.], 1988.
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The Brendan Legend: Texts And Versions (The Northern World: North Europe and the Baltic C.400-1700 Ad; Peoples, Economies and Cultures). Brill Academic Pub, 2006.
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Báez Daza, Eliana Yadira, Genaro Andrés Agudelo Castañeda, Lucero Gertrudis Rodriguez Silva, Roberto Antonio Coronado Silva, Luis Javier López Giraldo e Karen Stephanie Núñez Gómez. Caracterización agronómica, fisicoquímica, sensorial y de metabolitos con actividad funcional de cacaos especiales cultivados bajo sistemas agroforestales en el departamento de Santander. Corporación Colombiana de Investigación Agropecuaria (Agrosavia), 2022. http://dx.doi.org/10.21930/agrosavia.investigation.7405309.
Testo completoAbstract (sommario):
En el presente documento se hace una compilación de información producto de resultados de investigación cuyo objetivo principal fue la caracterización agronómica fisicoquímica, funcional y análisis sensorial de 22 genotipos regionales denominados TCS 01, 02, 04, 05, 06, 08, 10, 11, 12, 13, 19, 20, 40, 41, 42, 44, 45, 46, 47, 48 y 49, los cuales son producto de selección natural participativa, y el material TCS 03 que es producto de cruzamiento, así como la evaluación de dos genotipos introducidos y comercialmente distribuidos a nivel nacional ICS 95 y CCN 51. Esta evaluación fue ejecutada por el equipo científico y técnico de AGROSAVIA, en el Centro de Investigación La Suiza y la Universidad Industrial de Santander, desde el Laboratorio de Alimentos del CICTA encontrándose como resultado que los genotipos en estudio presentan un comportamiento productivo y sanitario de interés comercial (TCS 06, 01, 11, 13, 03 y 49), así como un potencial en su composición funcional (TCS 01, 04, 06, 13 y 47) y atributos sensoriales (TCS 01, 02, 05, 13, 19 y 06) además se desarrolló un modelo de predicción de perfiles. Toda la información consignada en este manuscrito sirve como base para investigadores, gremios, industriales, agricultores y comunidad académica, en la evaluación de nuevos genotipos de interés y ratificar a Colombia como país productor de cacao fino y aromatizado reconocido por la International Cocoa Organization (ICCO).
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Various bills and resolutions: Markup before the Committee on Foreign Affairs, House of Representatives, One Hundred Tenth Congress, first session, on H.R. 3887, H.R. 275, H.R. 1746, H.R. 3890, H.R. 2705, H.R. 2949, H.R. 3320, H.R. 3912, H.R. 3913, H.Res. 435, H. Res. 550, H. Res. 573, H. Res. 726, H. Res. 740, and H. Res. 747, H. Con. Res. 234, and H. Con. Res. 236, October 23, 2007. Washington: U.S. G.P.O., 2008.
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Gleń-Karolczyk, Katarzyna. Zabiegi ochronne kształtujące plonowanie zdrowotność oraz różnorodność mikroorganizmów związanych z czernieniem pierścieniowym korzeni chrzanu (Atmoracia rusticana Gaertn.). Publishing House of the University of Agriculture in Krakow, 2019. http://dx.doi.org/10.15576/978-83-66602-39-7.
Testo completoAbstract (sommario):
Horseradish roots, due to the content of many valuable nutrients and substances with healing and pro-health properties, are used more and more in medicine, food industry and cosmetics. In Poland, the cultivation of horseradish is considered minor crops. In addition, its limited size causes horseradish producers to encounter a number of unresolved agrotechnical problems. Infectious diseases developing on the leaves and roots during the long growing season reduce the size and quality of root crops. The small range of protection products intended for use in the cultivation of horseradish generates further serious environmental problems (immunization of pathogens, low effectiveness, deterioration of the quality of raw materials intended for industry, destruction of beneficial organisms and biodiversity). In order to meet the problems encountered by horseradish producers and taking into account the lack of data on: yielding, occurrence of infectious diseases and the possibility of combating them with methods alternative to chemical ones in the years 2012–2015, rigorous experiments have been carried out. The paper compares the impact of chemical protection and its reduced variants with biological protection on: total yield of horseradish roots and its structure. The intensification of infectious diseases on horseradish leaves and roots was analyzed extensively. Correlations were examined between individual disease entities and total yield and separated root fractions. A very important and innovative part of the work was to learn about the microbial communities involved in the epidemiology of Verticillium wilt of horseradish roots. The effect was examined of treatment of horseradish cuttings with a biological preparation (Pythium oligandrum), a chemical preparation (thiophanate-methyl), and the Kelpak SL biostimulator (auxins and cytokinins from the Ecklonia maxima algae) on the quantitative and qualitative changes occurring in the communities of these microorganisms. The affiliation of species to groups of frequencies was arranged hierarchically, and the biodiversity of these communities was expressed by the following indicators: Simpson index, Shannon–Wiener index, Shannon evenness index and species richness index. Correlations were assessed between the number of communities, indicators of their biodiversity and intensification of Verticillium wilt of horseradish roots. It was shown that the total yield of horseradish roots was on average 126 dt · ha–1. Within its structure, the main root was 56%, whereas the fraction of lateral roots (cuttings) with a length of more than 20 cm accounted for 26%, and those shorter than 20 cm for 12%, with unprofitable yield (waste) of 6%. In the years with higher humidity, the total root yield was higher than in the dry seasons by around 51 dt · ha–1 on average. On the other hand, the applied protection treatments significantly increased the total yield of horseradish roots from 4,6 to 45,3 dt · ha–1 and the share of fractions of more than 30 cm therein. Higher yielding effects were obtained in variants with a reduced amount of foliar application of fungicides at the expense of introducing biopreparations and biostimulators (R1, R2, R3) and in chemical protection (Ch) than in biological protection (B1, B2) and with the limitation of treatments only to the treatment of cuttings. The largest increments can be expected after treating the seedlings with Topsin M 500 SC and spraying the leaves: 1 × Amistar Opti 480 SC, 1 × Polyversum WP, 1 × Timorex Gold 24 EC and three times with biostimulators (2 × Kelpak SL + 1 × Tytanit). In the perspective of the increasing water deficit, among the biological protection methods, the (B2) variant with the treatment of seedlings with auxins and cytokinins contained in the E. maxima algae extract is more recommended than (B1) involving the use of P. oligandrum spores. White rust was the biggest threat on horseradish plantations, whereas the following occurred to a lesser extent: Phoma leaf spot, Cylindrosporium disease, Alternaria black spot and Verticillium wilt. In turn, on the surface of the roots it was dry root rot and inside – Verticillium wilt of horseradish roots. The best health of the leaves and roots was ensured by full chemical protection (cuttings treatment + 6 foliar applications). A similar effect of protection against Albugo candida and Pyrenopeziza brassicae was achieved in the case of reduced chemical protection to one foliar treatment with synthetic fungicide, two treatments with biological preparations (Polyversum WP and Timorex Gold 24 EC) and three treatments with biostimulators (2 × Kelpak SL, 1 × Tytanit). On the other hand, the level of limitation of root diseases comparable with chemical protection was ensured by its reduced variants R3 and R2, and in the case of dry root rot, also both variants of biological protection. In the dry years, over 60% of the roots showed symptoms of Verticillium wilt, and its main culprits are Verticillium dahliae (37.4%), Globisporangium irregulare (7.2%), Ilyonectria destructans (7.0%), Fusarium acuminatum (6.7%), Rhizoctonia solani (6.0%), Epicoccum nigrum (5.4%), Alternaria brassicae (5.17%). The Kelpak SL biostimulator and the Polyversum WP biological preparation contributed to the increased biodiversity of microbial communities associated with Verticillium wilt of horseradish roots. In turn, along with its increase, the intensification of the disease symptoms decreased. There was a significant correlation between the richness of species in the communities of microbial isolates and the intensification of Verticillium wilt of horseradish roots. Each additional species of microorganism contributed to the reduction of disease intensification by 1,19%.
Capitoli di libri sul tema "571.430 485"
1
Nève, Gabriel, Patrick Bonneau, Alain Coache, Artur Serrano e Gérard Filippi. "The Beetles (Coleoptera) of Príncipe, São Tomé and Annobón". In Biodiversity of the Gulf of Guinea Oceanic Islands, 295–348. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-06153-0_12.
Testo completoAbstract (sommario):
AbstractThe known beetle fauna of Príncipe, São Tomé, and Annobón amounts to 403 species and subspecies, of which 190 (47%) are endemic. The most diverse families of beetles are the Cerambycidae (61 species), the Tenebrionidae (57 species), the Carabidae (45 species), the Scarabaeidae (34 species), and the Coccinellidae (31 species). Most records come from São Tomé, with 297 species. In comparison, Príncipe, with 151 recorded species, and especially Annobón, with 16 recorded species, still require extensive faunistic investigations. The families Staphylinidae and Curculionidae probably hold numerous undescribed species and should be the focus of future research. Most of the endemic species live in forests. Therefore, the continued conservation of large forest areas on the islands is key to the long-term survival of their unique beetle fauna. As elsewhere, the beetle fauna will likely suffer from the effects of climatic change, and high-altitude species are likely to be the most severely affected.
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"Titel 9. Beweis durch Urkunden §415–§435". In Wieczorek/Schuetze Zivilprozeßordnung und Nebengesetze. §§ 128-541. Berlin, New York: De Gruyter, 2010. http://dx.doi.org/10.1515/9783899498479.629.
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Franzen, Dietmar, e Klaus Schäfer. "5.1 Investmentprozess". In Assetmanagement, 435–41. Schäffer-Poeschel, 2018. http://dx.doi.org/10.34156/9783791038308-435.
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Harrison, Dr Mark. "Thorax". In Revision Notes for MCEM Part A, 40–55. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199583836.003.0003.
Testo completoAbstract (sommario):
3.1 Thoracic body wall, 40 3.2 The diaphragm, 45 3.3 Thoracic inlet, 46 3.4 Trachea, 47 3.5 Thymus, 48 3.6 Heart and pericardium, 48 3.7 Oesophagus, 51 3.8 Pleura and lungs, 51 • See Figure A.3.1. • Thoracic part of the vertebral column...
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Loukopoulou, Louisa, e Adam Laitar. "Propontic Thrace". In An Inventory Of Archaic And Classical Poleis, 912–23. Oxford University PressOxford, 2004. http://dx.doi.org/10.1093/oso/9780198140993.003.0059.
Testo completoAbstract (sommario):
Abstract The European coast of the Propontis was settled by Megarians (no. 225) and Samians (no. 864). By 480 four colonies are recorded: viz. from east to west, Megarian Byzantion (no. 674) and Selymbria (no. 679), and Samian Perinthos (no. 678) and Bisanthe (no. 673), along with two probably smaller and presumably dependent settlements, Tyrodiza (no. 681) and Heraion [Teichos] (no. 676) (Loukopoulou (1989) 51–57).
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Croke, Brian. "Illyrians at Constantinople". In Count Marcellinus and his Chronicle, 78–102. Oxford University PressOxford, 2001. http://dx.doi.org/10.1093/oso/9780198150015.003.0004.
Testo completoAbstract (sommario):
Abstract In the preface to his chronicle Marcellinus makes clear to his audience that his preoccupation is chiefly with the eastern empire—Orientale tantum imperium. So we might reasonably expect to find little in the chronicle pertaining to affairs in the western empire, and then only in so far as such affairs affected Constantinople and the East. For Marcellinus the perspective and nomen clature of the Chronicle clearly divide East and West. There is a geographical east (Oriens: 418. 3, 420. 2, 484. 1, 529) and west (Occidens: 416. 1,468), as well as an imperial east (Orientale imperium: Praef.; Orientate respublica: 379. 1) and west (Occidentalis respublica: 434, 454. 2; Occidentalie imperium: 392. 1; Occidentale regnum: 424. 3; Hesperium regnum: 454. 2; Hesperium imperium: 476. 2; principatum Occidentis: 465. 2). There are also designated eastern emperors (Orientalibus principibus: 379. 1) and consuls (Orientalium consulum: 521). Not once after 395 does he refer to the Roman empire as a whole but only to its separate halves. However, on the occasions when he identifies himself as specifically Roman it is clearly as a citizen of the Roman empire as a whole, not just the eastern part of it. In speaking of ‘us’ (447. 2), ‘our generals’ (503), ‘this expedition of ours’ (529) and ‘our emperor’ (532, 533) he identifies him self as a citizen of the Roman world as distinguished from its foes,the Huns (447) and Persians (503, 529).’
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"Titel 9. Beweis durch Urkunden Titel 10. Beweis durch Parteivernehmung weggefallen §436–§455". In Wieczorek/Schuetze Zivilprozeßordnung und Nebengesetze. §§ 128-541. Berlin, New York: De Gruyter, 2010. http://dx.doi.org/10.1515/9783899498479.754.
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Marius, Arghirescu. "A Preonic Model of Quarks and Particles, Based on a Cold Genesis Theory". In Redefining Standard Model Particle Physics [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.109123.
Testo completoAbstract (sommario):
The theoretic model explains the generating of heavy quarks and of heavy particles using the known quark s(strange) and two semi-light quarks: λ±(435 MeV) and v±(∼574 MeV) resulting from a cold genesis theory1 of astro-particles’ forming, (CGT), the masses of the quarks c• (charm) and b• (bottom) of the Standard Model but also the values used by de Souza: c = 1.7 GeV and b = 5 GeV, being re-obtained as tri-quark clusters in the form: [(qq¯)q]], by a simple de-excitation reaction, with the emission of a preonic boson obtained in CGT: z0 = 34me, respective: z2 = 4z0 and zμ = 6z0- for the quarks b• and b. A similar de-excitation reaction, with emission of a preonic boson zk = n⋅z0, (n = 1÷7), representing less than 2.7% from the particle’s mass, explains the experimentally obtained masses of heavy baryons and mesons and of some multi-quark particles, with discrepancy <1% generally. The heavy current quarks result by lighter current quarks with quasi-crystalline internal structure, with trigonal/hexagonal symmetry of preonic kernels of two preonic bosons: z2 = 4z0; zπ = 7z0, the top-quark resulting as: t = 17(bb¯) + b = (7x5)⋅m(b), with a kernel of regular hexagonal polyhedron form, given by kernels of b-quarks. The model is compatible with the generation model and explains the quarks pairs forming from relativist e−- e+ jets.
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calendar, Martin J. Loessner richard. "The Listeria Bacteriophages". In The Bacteriophages, 593–601. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195168778.003.0037.
Testo completoAbstract (sommario):
Abstract Bacterial viruses specific for the genus Listeria were discovered almost 60 years ago (57), and were early reported for their usefulness in phage typing (61) of isolates of the pathogen Listeria monocytogenes (65). In the following years, phage typing of Listeria isolates has proven to be a very useful method, and led to the isolation of more than 400 phages for L. monocytogenes, L. ivanovii, and the nonpathogenic species L. innocua, L. seeligeri, and L. welshimeri (5, 9, 16, 19, 22, 25, 26, 31^33, 48^51, 53, 55, 63). To date, no phages infecting organisms of the species L. grayi have been found. This chapter briefly summarizes our present knowledge on Listeria phages, and gives an overview on their general and particular properties, with respect to both the basic science and the various practical applications.
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Loessner, Martin J., e Richard Calendar. "The Listeria Bacteriophages". In The Bacteriophages, 593–601. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195148503.003.0037.
Testo completoAbstract (sommario):
Abstract Bacterial viruses specific for the genus Listeria were discovered almost 60 years ago (57), and were early reported for their usefulness in phage typing (61) of isolates of the pathogen Listeria monocytogenes (65). In the following years, phage typing of Listeria isolates has proven to be a very useful method, and led to the isolation of more than 400 phages for L. monocytogenes, L. ivanovii, and the nonpathogenic species L. innocua, L. seeligeri, and L. welshimeri (5, 9, 16, 19, 22, 25, 26, 31^33, 48^51, 53, 55, 63). To date, no phages infecting organisms of the species L. grayi have been found. This chapter briefly summarizes our present knowledge on Listeria phages, and gives an overview on their general and particular properties, with respect to both the basic science and the various practical applications. Ultrastructure, Composition, and Taxonomy of Listeria Phages
Atti di convegni sul tema "571.430 485"
1
Spenard, Elisabeth, Julie Nguyen, S. Daisy Kosa e Taymaa May. "EP391/#571 Utilization of indocyanine green fluorescence angiography for anastomotic perfusion assessment following bowel resection for gynecologic malignancies: a pan-Canadian survey". In IGCS 2022 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-igcs.480.
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Sakata, Mikihiro, Tomoaki Kiso, Masayuki Tanaka e Yasuhiro Sato. "Difference in Susceptibility to 475°C Embrittlement of Duplex Stainless Steel Base Metal and Weld Metal". In ASME 2018 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/pvp2018-84361.
Testo completoAbstract (sommario):
Duplex and super duplex stainless steels are susceptible to thermal aging embrittlement, referred to as 475°C (885°F) embrittlement. The object of this study is to understand the difference in susceptibility to 475°C (885°F) embrittlement of the base metal and the weld metal of these steels. Isothermal aging heat treatment at 300–450 °C (570–840°F) up to 1,000 hours was performed on 22% Cr duplex stainless steel: UNS S32205 and 25% Cr super duplex stainless steel: UNS S32750 and S32760 and these weld metals made using their matching SMAW electrodes or GTAW rods. After heat treatment, the embrittlement behavior was evaluated by Charpy impact test and Vickers hardness test. The results revealed the time-temperature embrittlement curves of the weld metals were displaced to a significantly shorter period of time and extended to lower temperatures compared to those of the corresponding base metals. More importantly, these results suggested that the maximum design temperature limit on these steels currently specified in the ASME Pressure Piping Codes and Boiler and Pressure Vessel Code is not always sufficient to avoid the risk of 475°C (885°F) embrittlement in their welded components.
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Calkins, David J. "Discrimination and sensation in the opponent colors channels". In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1990. http://dx.doi.org/10.1364/oam.1990.thdd7.
Testo completoAbstract (sommario):
"Indiscriminability action spectra" of the red/green opponent channel can be measured by using a foveally presented 500 ms raised cosine without spatial edges. These spectra represent lights that are rendered indiscriminable at a cone-antagonistic locus. I found that mid-waveand long-wave low-frequency stimuli falling on the same contour, when presented simultaneously on an intense 578 nm adapting field, cancel the "green" and "red" sensations, respectively, elicited by each. That is, the isocancellation contours of the red/green channel are identical to the indiscriminability spectra. Also, using the low-frequency stimulus, I isolated a short-wave mechanism that codes a single "violet" both at and above threshold. Lights between 400 and 489 nm, which fall on the same indiscriminability contour up to 2 log units suprathreshold, are indiscriminable. This single "violet" is distinct from a single "blue" elicited by a second short-wave mechanism whose sensitivity is suppressed by a 578 nm adapting field. This mechanism is manifestly opponent since the color it codes is cancelled by an appropriate yellow low-frequency light.
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Farrag, Sayed, e Ihab Mahmoud. "Petrophysical Evaluation and Geochemical Characterization of Abu Roash F Member Abu Gharadig Basin, Western Desert, Egypt". In International Petroleum Technology Conference. IPTC, 2022. http://dx.doi.org/10.2523/iptc-22187-ms.
Testo completoAbstract (sommario):
Abstract Abu Roash F Member (ARF) is a carbonate formation extended all over the Western Desert in Egypt, ARF has good lateral continuity in all western desert basins but has very poor connectivity and very low permeability. it can be considered as an example of unconventional reservoir. This work aims to evaluate the reservoir quality of Abu Roash "F" Member and compare with the unconventional play commercial developed all over the world. in this study, the key parameters to define reservoir quality; include mineralogy, porosity, water saturation, permeability, organic matter content, Kerogen type and thermal maturity has been investigated. More than 30 Rock-Eval pyrolysis samples from different fields where ARF at significantly different level has been used to evaluate and understand ARF geochemical reservoir quality. On the other side, core and well log data from different fields at different level has been inspected and integrated to evaluate ARF mineralogy, porosity, permeability, water saturation, and identify Potential sweet spots. The results of Rock-Eval analysis show that most of the investigated samples have the total organic carbon content (TOC) values between 1.6 and 6.63 wt% indicating good to very good source rocks and the pyrolysis Yield (PY) ranged from 6 to 20 indicating good to very good potential generation. Based on Tmax and Hydrogen index (HI), the deepest well samples have Tmax values in the range of 435 and 441°C and Hydrogen index (HI) values in the range of 311 to 570 indicating that the organic matter has reached the early to intermediate stages of thermal maturity with dominate kerogen type I-II. While the shallower well samples have Tmax values in the range of 421 and 430°C and Hydrogen index (HI) values in the range of 127 to 687 indicating that the organic matter immature with mixed kerogen type II-III. Petrophysical results supporting that ARF is a carbonate rock deposit under marine conditions and has mixed layer clay (montomonlionite, Kolonite and illite). Numerous techniques to estimate ARF permeability from wireline logs have been investigated, using the available core data porosity permeability relationship has been established. Moreover, the results of petrophysical analysis indicate that Lucia class 3 permeability has good math with core permeability. So, Lucia class 3 permeability can be used to estimate ARF permeability using the calculated effective porosity from well log data. Generally, the results of geochemical and petrophysical evaluation of this study show that ARF has very good reservoir quality comparing with the most of commercially developed unconventional resources all over the world. Moreover, the results show that ARF has a similarity with Eagle Ford Shale in terms of Age, mineralogy, pressure, depth, thickness, and TOC which reflect the potentiality of ARF commercial development.
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Moreira, Debora C., Gherhardt Ribatski e Satish G. Kandlikar. "Effects of Taper Configurations on Heat Transfer and Pressure Drop in Single-Phase Flows in Microgaps". In ASME 2020 18th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2020 Heat Transfer Summer Conference and the ASME 2020 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/icnmm2020-1012.
Testo completoAbstract (sommario):
Abstract This paper presents a comparison of heat transfer and pressure drop during single-phase flows inside diverging, converging, and uniform microgaps using distilled water as the working fluid. The microgaps were created on a plain heated copper surface with a polysulfone cover that was either uniform or tapered with an angle of 3.4°. The average gap height was 400 microns and the length and width dimensions were 10 mm × 10 mm, resulting in an average hydraulic diameter of approximately 800 microns for all configurations. Experiments were conducted at atmospheric pressure and the inlet temperature was set to 30 °C. Heat transfer and pressure drop data were acquired for flow rates varying from 57 to 485 ml/min and the surface temperature was monitored not to exceed 90 °C to avoid bubble nucleation, so the heat flux varied from 35 to 153 W/cm2 depending on the flow rate. The uniform configuration resulted in the lowest pressure drop, and the diverging one showed slightly higher pressure drop values than the converging configuration, possibly because the flow is most constrained at the inlet section, where the fluid is colder and presents higher viscosity. In addition, a minor dependence of pressure drop with heat flux was observed due to temperature dependent properties. The best heat transfer performance was obtained with the converging configuration, which was especially significant at low flow rates. This behavior could be explained by an increase in the heat transfer coefficient due to flow acceleration in converging gaps, which compensates the decrease in temperature difference between the fluid and the surface due to fluid heating along the gap. Overall, the comparison between the three configurations shows that converging microgaps have better performance than uniform or diverging ones for single-phase flows, and such effect is more pronounced at lower flow rates, when the fluid experiences higher temperature changes.
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Yang, Nicholas H., Kathleen Allen Rodowicz e David Dainty. "Baseball Head Impacts to the Non-Helmeted and Helmeted Hydrid III ATD". In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38648.
Testo completoAbstract (sommario):
Traumatic brain injury may occur in baseball due to a head impact with a thrown, pitched, or batted ball. It has been shown that the average pitching speed of youth pitchers and high school pitchers is approximately 63 mph (28 m/s) and 74 mph (33 m/s), respectively. At pitching speeds of approximately 52 mph (23 m/s), the bat exit velocity (BEV) for metal bats has been shown to be approximately 100 mph (45 m/s). Head kinematics, such as linear and angular head accelerations, are often used to establish head injury risk for head impacts. With a possible ball impact velocity reaching speeds in excess of those typically tested for baseball headgear, it is necessary to understand how the head will respond to high velocity impacts in both helmeted and non-helmeted situations. In this study, head impacts were delivered to the front and side of a Hybrid III 50th percentile male anthropomorphic test device (ATD) by a baseball traveling at speeds of 60 mph (27 m/s), 75 mph (34 m/s), and 100 mph (45 m/s). Head impacts were performed on the non-helmeted ATD head and with the ATD wearing a standard batting helmet certified in accordance with the NOCSAE standard. The Hybrid III headform was instrumented with a nine accelerometer array to measure linear accelerations of the head and determine angular accelerations. Peak resultant linear head accelerations for the non-helmeted ATD were approximately 200–400 g for frontal impacts and approximately 220–480 g for lateral impacts. Peak resultant angular head accelerations for the non-helmeted condition were approximately 17,000–32,000 rad/s2 for frontal impacts and approximately 30,000–60,000 rad/s2 for lateral impacts. For the helmeted ATD, peak resultant linear accelerations of the head were approximately 70–300 g for frontal impacts and approximately 80–360 g for lateral impacts. Peak resultant angular head accelerations for the helmeted ATD were approximately 5,000–14,000 rad/s2 for frontal impacts and approximately 7,500–30,000 rad/s2 for lateral impacts. HIC values for the non-helmeted ATD were approximately 193–1,025 for frontal impacts and approximately 241–1,588 for lateral impacts. SI values for the non-helmeted ATD were approximately 235–1,267 for frontal impacts and approximately 285–1,844 for lateral impacts. HIC values for the helmeted ATD were approximately 16–415 for frontal impacts and approximately 23–585 for lateral impacts. SI values for the helmeted ATD were approximately 25–521 for frontal impacts and approximately 32–708 for lateral impacts. In comparison to the non-helmeted condition, the results demonstrate the effectiveness of a batting helmet in mitigating head accelerations for the frontal and lateral impact conditions tested.
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Velzing, Evert-Jan, Annemiek Van der Meijden, Kitty Vreeswijk e Ruben Vrijhoef. "Circularity in value chains for building materials". In CARPE Conference 2019: Horizon Europe and beyond. Valencia: Universitat Politècnica València, 2019. http://dx.doi.org/10.4995/carpe2019.2019.10196.
Testo completoAbstract (sommario):
AbstractThe urgency for developing a circular economy is growing, and more and more companies and organisations are concerned with the importance of adapting their business to fit a changing economy. However, many analyses on the circular economy are still rather abstract and there is a lack of understanding about what circularity would mean for specific industries. This insufficient insight especially seems to be apparent in the building and construction sector. Besides, the building and construction sector is responsible for a major part of energy use and emissions. To tackle the issue of insufficient insight into the business consequences of circular devlopments, further research is necessary. Therefore, we propose to collaborate on a research project that aims to provide a more detailed level of analysis. The goal is to identify drivers and barriers to make better use of materials in the building and construction sector. This further research would benefit from an international collaboration between universities of applied sciences and industry from different European countries. An additional benefit of the applied orientation would be the relevance for professional education programmes. References CBS, PBL & Wageningen UR. (2017). Vrijkomen en verwerking van afval per doelgroep, 1990-2014 (indicator 0206, versie 13, 26 janauri2017). Retrieved from: https://www.clo.nl/indicatoren/nl0206-vrijkomen-en-verwerking-van-afval-per-doelgroep Cuchí, A.; Arcas, J.; Casals, M. & Fobella, G. (2014). Building a common home Building sector – A global vision report. Produced by the Global Vision Area within the World SB14 Barcelona Conference. De Jesus, A. & Mendonça, S. (2018). Lost in Transition? Drivers and Barriers in the Eco-innovation Road to the Circular Economy. Ecological Economics, 145, 75-89. doi: 10.1016/j.ecolecon.2017.08.001. EC. (2015). Closing the Loop – An EU action plan for the Circular Economy. Brussels: European Commission. EC. (2019). Report from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions on the implementation of the Circualr Economy Action Plan. Brussels: European Commission. Ghisellini, P; Cialini, C. & Ulgiati, S. (2016). A review on circular economy: the expected transition to a balanced interplay of environmental and economic systems. Journal of Cleaner Production, 114, 11-32. doi: 10.1016/j.jclepro.2015.09.007. Kirchherr, J., Pisciceli, L., Bour, R., Kostense-Smit, E., Muller, J., Huibrechtse-Truijens, A. & Hekkert, M. (2018). Barriers to the Circular Economy: Evidence From the European Union (EU). Ecological Economics, 150, 264-272. Mazzucato, M. (2018). Mission-Oriented Research & Innovation in the European Union – A problem-solving approach to fuel innovation-led growth. Retrieved from: European Commission; https://ec.europa.eu/info/sites/info/files/mazzucato_report_2018.pdf Nederland circulair in 2050. Rijksbreed programma Circulaire Economie (2016). Den Haag: Ministerie van Infrastructuur en Milieu & Ministerie van Economische Zaken. Stahel, W.R. (2016) The Circular Economy. Nature, 531(7595), 435-438. UN. (2018). 2018 Global Status Report – Towards a zero-emission, efficient and resilient buildings and construction sector. United Nations Environment Programme. UNCTAD. (2018). Circular Economy: The New Normal (Policy Brief No. 61). Retrieved from United Nations Conference on Trade and Development (UNCTAD): https://unctad.org/en/PublicationsLibrary/presspb2017d10_en.pdf
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Jackson, C. W., N. K. Hutson, S. A. Steward e H. H. Edwards. "THE WISTAR-FURTH RAT: AN ANIMAL MODEL OF HEREDITARY MACRO THROMBOCYTOPENIA". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643925.
Testo completoAbstract (sommario):
The mechanisms which determine and regulate platelet size are unknown. By phase microscopy, we serendipitously observed that Wistar/Furth (W/F) rats had macrothrombocytopenia. In this study, we have characterized and compared platelets and megakaryocytes (MK) of W/F rats to those of Wistar (W), Long-Evans hooded (LE) and Sprague-Dawley (SD) rats. In addition, we have examined the mode of inheritance of this W/F rat platelet abnormality. Average platelet count of W/F rats was only 312 ± 57 x 103/mm3 compared to 1086 ± 68, 868 ± 91 and 926 ± 82 x 103/mm3 respectively for W, LE and SD rats. Mean platelet volume (MPV) of W/F rats (8.1 ± 1.4 fl) was twice that of W (4.0 ± 0.2 fl), LE (4.2 ± 0.3 f1) and SD (4.1 ± 0.2 f1) rats. However, average MK diameter and DNA content distribution of W/F rats were not significantly different than those of LE rats. Average MK concentration was somewhat lower (4.5 MK/high power field) in the W/F strain compared to that of LE rats (6.6 MK/HPF). Maze-like membrane formations were observed in W/F MK and platelets by electron microscopy. Reciprocal crosses of W/F and LE rats resulted in offspring with MPVs (4.2 fl) and platelet counts like those of LE rats, indicating that the macrothrombocytopenic trait is recessive in its inheritance. Reciprocal marrow transplants between the W/F and LE strains resulted in MPVs like those of the donor strain indicating that the macrothrombocytopenia is an intrinsic marrow abnormality of the W/F strain. Analysis of W/F platelets by two-dimensional polyacrylamide gel electrophoresis revealed two readily detectable differences from those of W and LE rats: (1) absence of a protein of MW of 41,000 and pi of 6.35 and (2) presence of a protein of MW of 35,000 and pi of 5.9. In summary, the W/F rat has a hereditary macrothrombocytopenia which is recessive in nature and not due to differences in MK size or DNA content. These results suggest that the macrothrombocytopenia of W/F rats results from formation of fewer platelets per MK, possibly due to a qualitative or quantitative defect in some component necessary for proper subdivision of megakaryocyte cytoplasm into platelets.
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Виктор, С. А., И. В. Курлович, Т. П. Ващилина e В. А. Прилуцкая. "НЕПРОПОРЦИОНАЛЬНАЯ ФОРМА ФЕТАЛЬНОЙ МАКРОСОМИИ: РОЛЬ САХАРНОГО ДИАБЕТА И ОЖИРЕНИЯ". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-114.
Testo completoAbstract (sommario):
ЦЕЛЬ: выявить взаимосвязь между наличием нарушений углеводного и/или жирового обмена у бере-
менных женщин и формированием непропорционально развитых макросомных новорожденных.
МАТЕРИАЛЫ И МЕТОДЫ: проведен ретроспективный анализ историй родов 243 родильниц и их
макросомных новорожденных детей (4000 г и более). Для новорожденных была проведена оценка про-
порциональности физического развития с расчетом масса-ростового индекса (МРИ, отношение массы
тела (кг) к длине тела (м)) и его центильной оценкой относительно гестационного возраста и пола ново-
рожденного с использованием онлайн калькулятора INTERGROWTH-21st. Сформировано 2 группы с учетом
пропорциональности развития новорожденного:
-- группа 1 – 119 родильниц и их новорожденные дети с МРИ менее 90 центиля (макросомные пропорци-
онально развитые новорожденные);
-- группа 2 – 124 родильниц и их новорожденные дети с МРИ, соответствующим 90 центилю и более (ма-
кросомные непропорционально развитые новорожденные).
Анализируемые группы были сопоставимы по возрасту матери: в группе 1 возраст матерей составил 31
(27–35) лет, в группе А2 – 31 (27–34) лет (р=0,751). Масса тела новорожденных в группе 1 составила 4090
(4050–4185) г, в группе 2 – 4295 (4200-4430) г (р<0,001); длина тела в группе 1 – 56 (55–57) см, в группе 2 – 55
(54-56) см (р<0,001); центильная оценка МРИ в группе 1 – 96,3 (93,0-98,6) %, в группе 2 – 81,3 (74,4-86,1) %
(р<0,001). Статистическую обработку полученных данных выполнили с использованием статистической
программы «STATISTICA 10». Статистически значимыми принимали различия при p<0,05.
РЕЗУЛЬТАТЫ: наибольшие значения массы тела и индекс массы тела (ИМТ) до беременности отмеча-
лись у матерей в группе 2 (73 (63–83) кг и 26,0 (22,9–30,4) кг/м2 соответственно), по сравнению с группой 1,
где они составили 68 (59–76) кг (р=0,005) и 23,2 (20,9–26,5) кг/м2 (р<0,001) соответственно. При проведении
корреляционного анализа была выявлена прямая корреляционная связь умеренной силы между массой
новорожденного и прегестационной массой тела матери (rs=0,36, p<0,001) и ИМТ до беременности (rs=0,32,
p<0,001). У матерей непропорционально развитых новорожденных избыток массы тела (ИМТ 25,0-29,9) или
ожирение (ИМТ 30,0 и более) (57,3 % случаев) диагностировались статистически значимо чаще по срав-
нению с группой 1 (ОШ 2,46 (1,46-4,12), р=0,007). Сахарный диабет (прегестационный или гестационный)
статистически значимо чаще регистрировался в группе 2 (в 39,5% случаев) по сравнению с группой 1 (7,6 %
случаев, ОШ 7,99 (3,70-17,23), р<0,001).
ВЫВОДЫ: на формирование непропорционального избыточного роста плода оказывает влияние на-
личие у беременной женщины избытка массы тела или ожирения до беременности (ОШ 2,46 (1,46-4,12),
р=0,007) или прегестационного или гестационного сахарного диабет (ОШ 7,99 (3,70-17,23), р<0,001).
10
Nakka, Thejeswar, Prasanth Ganesan, Luxitaa Goenka, Biswajit Dubashi, Smita Kayal, Latha Chaturvedula, Dasari Papa, Prasanth Penumadu, Narendran Krishnamoorthy e Divya B. Thumaty. "Epithelial Ovarian Cancer: Real-World Outcomes". In Annual Conference of Indian Society of Medical and Paediatric Oncology (ISMPO). Thieme Medical and Scientific Publishers Pvt. Ltd., 2021. http://dx.doi.org/10.1055/s-0041-1735369.
Testo completoAbstract (sommario):
Abstract Introduction Ovarian cancer is the third most common cancer and the second most common cause of death among gynecological cancers in Indian women. Ovarian cancer is heterogeneous, among them, epithelial ovarian cancer (EOC) is the most common. Primary cytoreductive surgery along with six to eight cycles of a combination of platinum and taxanes chemotherapy is the cornerstone of first-line treatment in EOC. This study was done to find clinicopathological factors affecting survival outcomes with first-line therapy in EOC in a real-world setting. Objectives This study was aimed to find factors affecting progression-free survival (PFS) and overall survival (OS) with first-line treatment in EOC. Materials and Methods We conducted a single-center retrospective study. We screened all the patients diagnosed with ovarian cancer from January 2015 till December 2019. We locked data in August 2019. Eligible patients were histologically confirmed EOC who underwent primary cytoreduction or received more than or equal to two cycles of chemotherapy or both. Patients who had received first-line treatment at another hospital were excluded. Results Patients demographics and clinical characteristics: between January 5, 2015 to August 31, 2019, 435 patients with a diagnosis of ovarian malignancy were registered at our center. Among them, 406 (82%) had EOC, 290 (64%) newly diagnosed, and fulfilling eligibility criteria were included in the final analysis. The median age of the cohort was 53 years (range: 21–89 years) and 157 patients (54%) were >50 years of age (the Eastern Oncology Cooperative Group Performance status was ≥ 2 in 124 patients [43%]; median duration of symptoms was 3 months; and stage III/IV: 240 [83%]). Grading of the tumor was available in 240 patients of which 219 (91%) were of high grade. Subtyping was available in 272 patients (94%) of which the serous subtype was the most common constituting 228 patients (79%).Treatment Most patients received chemotherapy (n = 283 [98%]) as the first modality of treatment (neoadjuvant/adjuvant and palliative). As neoadjuvant (NACT) in 130 patients (45%) and as adjuvant following surgery in 81 patients (29%). The most common chemotherapy regimen was a combination of carboplatin and paclitaxel in 256 patients (88%). Among 290 patients 218 (75%) underwent cytoreductive surgery. Among them, optimal cytoreduction was achieved in 108 patients (52%). Optimal cytoreduction rate (OCR) with upfront surgery and after NACT was 44 and 53%, respectively (Chi-square test: 0.86; p = 0.35).Survival The median follow-up of the study was 17 months (range: 10–28 months) and it was 20 months (range: 12–35 months) for patients who were alive. At last, follow-up, 149 patients (51%) had progressed and 109 (38%) died. The estimated median PFS and OS were 19 months (95% CI: 16.1–21.0) and 39 months (95% CI: 29.0–48.8), respectively. On multivariate analysis, primary surgery (HR: 0.1, 95% CI: 0.06–0.21; p-value: <0.001) and early-stage disease (HR: 0.2, 95% CI: 0.1–0.6; p-value 0.04) were associated with superior PFS and primary surgery (HR: 0.1, 95% CI: 0.09–0.2; p-value: <0.001) was associated with superior OS. Conclusion Primary surgery (upfront or interval) was associated with improved survival. Newer agents like bevacizumab, poly-ADP (adenosine diphosphate)-ribose polymerase inhibitors and HIPEC should be incorporated precisely into first line of therapy to improve outcomes.
Rapporti di organizzazioni sul tema "571.430 485"
1
Padget, C. D. W., D. R. M. Pattison, D. P. Moynihan e O. Beyssac. Pyrite and pyrrhotite in a prograde metamorphic sequence, Hyland River region, SE Yukon: implications for orogenic gold. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328987.
Testo completoAbstract (sommario):
The distribution of pyrite and pyrrhotite is documented within an andalusite-sillimanite type (high-temperature, low-pressure) metasedimentary succession exposed in the Hyland River region of southeastern Yukon, Canada. The following metamorphic zones are recognized: chlorite, biotite, cordierite/staurolite (porphyroblast-in), andalusite, sillimanite, and K-feldspar + sillimanite. Pyrite occurs in the chlorite zone through the biotite zone, while pyrrhotite occurs from the chlorite zone to K-feldspar + sillimanite zone. The pyrite-pyrrhotite transition, therefore, occupies an interval in the chlorite and lower biotite zones that is terminated upgrade by a pyrite-out isograd in the upper part of the biotite zone or lowest grade part of the cordierite/staurolite zone. Pressure and temperature conditions of the rocks were estimated from phase equilibrium modelling and from Raman spectroscopy of carbonaceous material (RSCM) thermometry. Modelling indicates pressures of 3.7-4.1 kbar with temperatures of ~425 °C at the biotite isograd, 560-570 °C for chlorite-out/porphyroblast-in, ~575 °C for andalusite-in, 575-600 °C for the sillimanite isograd, and 645-660 °C at the K-feldspar + sillimanite isograd. RSCM temperatures are greater than or equal to 420 °C in the Chl zone, 500 °C at the Bt isograd, 525-550 °C for porphyroblast-in isograd, ~550 °C at the And isograd, and 580 °C at the Sil isograd. These results suggest the pyrite-pyrrhotite transition occurs from less than or equal to 420°C to ~560 °C. Thermodynamic modelling shows 0.6 wt. % H2O is released during metamorphism over the ~140 °C interval of the pyrite-pyrrhotite transition. The gradual release of fluid in the biotite zone is interpreted to have broadened the pyrite-pyrrhotite transition compared to other studies that predict a small interval of vigorous fluid release associated with volumetric chlorite consumption. Samples from the pyrite-pyrrhotite transition zone contain lower whole rock and pyrite Au values than samples from unmetamorphosed/lower rocks, suggesting that Au was removed from the rock at conditions below the pyrite-pyrrhotite transition (&lt;420 °C). The chlorite zone and higher-grade metamorphic rocks of the Hyland River area do not appear to be a plausible source region for orogenic gold.
2
Atal, Juan Pablo, Pedro Zitko, Catalina Gutiérrez e Úrsula Giedon. ¿Cuánto podrían ahorrar y qué ganarían los hogares Chilenos usando medicamentos genéricos en vez de sus equivalentes del marca? Banco Interamericano de Desarrollo, settembre 2023. http://dx.doi.org/10.18235/0005158.
Testo completoAbstract (sommario):
En Chile, el gasto en salud pagado directamente por los hogares el gasto de bolsillo en salud es de 32 por ciento del total, uno de los más altos entre los países de la OCDE. De este gasto, 40 por ciento corresponde a la adquisición de medicamentos. 40 por ciento de los medicamentos ambulatorios a los que accede la población chilena son adquiridos de forma particular en el mercado del retail a través de farmacias privadas. Este trabajo cuantifica cuánto podrían ahorrar los hogares si compraran medicamentos genéricos sin marca en vez de sus equivalentes de marca. Adicionalmente, estima cómo se distribuiría este ahorro por nivel socioeconómico y calcula su costo de oportunidad en términos de gasto de bolsillo y consumo de otros bienes en el hogar. Los resultados indican que existe la posibilidad de sustitución para 29 por ciento del valor del mercado y que el ahorro potencial alcanzaría los 315 millones de dólares anuales. Esto corresponde a un ahorro potencial de 48 por ciento en este segmento. Adicionalmente, para 51 por ciento del mercado no hay sustitutos genéricos disponibles a pesar de que los medicamentos de este segmento perdieron la patente y existen alternativas genéricas con registro sanitario en Chile u otros países. El ahorro potencial de sustituir productos de marca por productos genéricos reduciría 4 por ciento el gasto total en salud de los hogares y 10 por ciento el gasto en medicamentos. Los ahorros son más importantes para hogares con menor nivel educativo entre 12 y 17 por ciento del gasto en medicamentos. Para ilustrar la importancia en términos de otros gastos del hogar, este ahorro permitiría a los hogares con menor nivel educativo pagar cerca de 50 días de transporte por año o más de 2 meses de transporte de días laborales.
3
Pavlovic, Noel, Barbara Plampin, Gayle Tonkovich e David Hamilla. Special flora and vegetation of Indiana Dunes National Park. National Park Service, 2024. http://dx.doi.org/10.36967/2302417.
Testo completoAbstract (sommario):
The Indiana Dunes (comprised of 15 geographic units (see Figure 1) which include Indiana Dunes National Park, Dunes State Park, and adjacent Shirley Heinze Land Trust properties) are remarkable in the Midwest and Great Lakes region for the vascular plant diversity, with an astounding 1,212 native plant species in an area of approximately 16,000 acres! This high plant diversity is the result of the interactions among postglacial migrations, the variety of soil substrates, moisture conditions, topography, successional gradients, ?re regimes, proximity to Lake Michigan, and light levels. This richness is all the more signi?cant given the past human alterations of the landscape resulting from logging; conversion to agriculture; construction of transportation corridors, industrial sites, and residential communities; ?re suppression; land abandonment; and exotic species invasions. Despite these impacts, multiple natural areas supporting native vegetation persist. Thus, each of the 15 units of the Indiana Dunes presents up to eight subunits varying in human disturbance and consequently in ?oristic richness. Of the most signi?cant units of the park in terms of number of native species, Cowles Dunes and the Dunes State Park stand out from all the other units, with 786 and 686 native species, respectively. The next highest ranked units for numbers of native species include Keiser (630), Furnessville (574), Miller Woods (551), and Hoosier Prairie (542). The unit with lowest plant richness is Heron Rookery (220), with increasing richness in progression from Calumet Prairie (320), Hobart Prairie Grove (368), to Pinhook Bog (380). Signi?cant natural areas, retaining native vegetation composition and structure, include Cowles Bog (Cowles Dunes Unit), Howes Prairie (Cowles Dunes), Dunes Nature Preserve (Dunes State Park), Dunes Prairie Nature Preserve (Dunes State Park), Pinhook Bog, Furnessville Woods (Furnessville), Miller Woods, Inland Marsh, and Mnoke Prairie (Bailly). Wilhelm (1990) recorded a total of 1,131 native plant species for the ?ora of the Indiana Dunes. This was similar to the 1,132 species recorded by the National Park Service (2014) for the Indiana Dunes. Based on the nomenclature of Swink and Wilhelm (1994), Indiana Dunes National Park has 1,206 native plant species. If we include native varieties and hybrids, the total increases to 1,244 taxa. Based on the nomenclature used for this report?the Flora of North America (FNA 2022), and the Integrated Taxonomic Information System (ITIS 2022)?Indiana Dunes National Park houses 1,206 native vascular plant species. As of this writing (2020), the Indiana Dunes is home to 37% of the species of conservation concern in Indiana (241 out of 624 Indiana-listed species): state extirpated = 10 species, state endangered = 75, and state threatened = 100. Thus, 4% of the state-listed species in the Indiana Dunes are extirpated, 31% endangered, and 41% threatened. Watch list and rare categories have been eliminated. Twenty-nine species once documented from the Indiana Dunes may be extirpated because they have not been seen since 2001. Eleven have not been seen since 1930 and 15 since 1978. If we exclude these species, then there would be a total of 1,183 species native to the Indiana Dunes. Many of these are cryptic in their life history or diminutive, and thus are di?cult to ?nd. Looking at the growth form of native plants, <1% (nine species) are clubmosses, 3% (37) are ferns, 8% (297) are grasses and sedges, 56% (682) are forbs or herbs, 1% (16) are herbaceous vines, <1% (7) are subshrubs (woody plants of herbaceous stature), 5% (60) are shrubs, 1% (11) are lianas (woody vines), and 8% (93) are trees. Of the 332 exotic species (species introduced from outside North America), 65% (219 species) are forbs such as garlic mustard (Alliaria petiolata), 15% (50 species) are graminoids such as phragmites (Phragmites australis ssp. australis), 2% (seven species) are vines such as ?eld bindweed (Convulvulus arvensis), <1% (two species) are subshrubs such as Japanese pachysandra (Pachysandra terminalis), 8% (28 species) are shrubs such as Asian bush honeysuckle (Lonicera spp.), 1% (three species) are lianas such as oriental bittersweet (Celastrus orbiculatus), and 8% (23 species) are trees such as tree of heaven (Ailanthus altissimus). Of the 85 adventive species, native species that have invaded from elsewhere in North America, 14% (11 species) are graminoids such as broom sedge (Andropogon virginicus), 57% (48 species) are forbs such as fall phlox (Phlox paniculata), 5% (six species) are shrubs such as Carolina allspice (Calycanthus floridus), 3% (two species) are subshrubs such as holly leaved barberry (Berberis repens), 1% (one species) is a liana (trumpet creeper (Campsis radicans), 3% two species) are herbaceous vines such as tall morning glory (Ipomoea purpurea), and 17% (15 species) are trees such as American holly (Ilex opaca). A total of 436 species were found to be ?special? based on political rankings (federal and state-listed threatened and endangered species), species with charismatic ?owers, and those that are locally rare.
4
Sela, Hanan, Eduard Akhunov e Brian J. Steffenson. Population genomics, linkage disequilibrium and association mapping of stripe rust resistance genes in wild emmer wheat, Triticum turgidum ssp. dicoccoides. United States Department of Agriculture, gennaio 2014. http://dx.doi.org/10.32747/2014.7598170.bard.
Testo completoAbstract (sommario):
The primary goals of this project were: (1) development of a genetically characterized association panel of wild emmer for high resolution analysis of the genetic basis of complex traits; (2) characterization and mapping of genes and QTL for seedling and adult plant resistance to stripe rust in wild emmer populations; (3) characterization of LD patterns along wild emmer chromosomes; (4) elucidation of the multi-locus genetic structure of wild emmer populations and its correlation with geo-climatic variables at the collection sites. Introduction In recent years, Stripe (yellow) rust (Yr) caused by Pucciniastriiformis f. sp. tritici(PST) has become a major threat to wheat crops in many parts of the world. New races have overcome most of the known resistances. It is essential, therefore, that the search for new genes will continue, followed by their mapping by molecular markers and introgression into the elite varieties by marker-assisted selection (MAS). The reservoir of genes for disease and pest resistance in wild emmer wheat (Triticumdicoccoides) is an important resource that must be made available to wheat breeders. The majority of resistance genes that were introgressed so far in cultivated wheat are resistance (R) genes. These genes, though confering near-immunity from the seedling stage, are often overcome by the pathogen in a short period after being deployed over vast production areas. On the other hand, adult-plant resistance (APR) is usually more durable since it is, in many cases, polygenic and confers partial resistance that may put less selective pressure on the pathogen. In this project, we have screened a collection of 480 wild emmer accessions originating from Israel for APR and seedling resistance to PST. Seedling resistance was tested against one Israeli and 3 North American PST isolates. APR was tested on accessions that did not have seedling resistance. The APR screen was conducted in two fields in Israel and in one field in the USA over 3 years for a total of 11 replicates. We have found about 20 accessions that have moderate stripe rust APR with infection type (IT<5), and about 20 additional accessions that have novel seedling resistance (IT<3). We have genotyped the collection using genotyping by sequencing (GBS) and the 90K SNP chip array. GBS yielded a total 341K SNP that were filtered to 150K informative SNP. The 90K assay resulted in 11K informative SNP. We have conducted a genome-wide association scan (GWAS) and found one significant locus on 6BL ( -log p >5). Two novel loci were found for seedling resistance. Further investigation of the 6BL locus and the effect of Yr36 showed that the 6BL locus and the Yr36 have additive effect and that the presence of favorable alleles of both loci results in reduction of 2 grades in the IT score. To identify alleles conferring adaption to extreme climatic conditions, we have associated the patterns of genomic variation in wild emmer with historic climate data from the accessions’ collection sites. The analysis of population stratification revealed four genetically distinct groups of wild emmer accessions coinciding with their geographic distribution. Partitioning of genomic variance showed that geographic location and climate together explain 43% of SNPs among emmer accessions with 19% of SNPs affected by climatic factors. The top three bioclimatic factors driving SNP distribution were temperature seasonality, precipitation seasonality, and isothermality. Association mapping approaches revealed 57 SNPs associated with these bio-climatic variables. Out of 21 unique genomic regions controlling heading date variation, 10 (~50%) overlapped with SNPs showing significant association with at least one of the three bioclimatic variables. This result suggests that a substantial part of the genomic variation associated with local adaptation in wild emmer is driven by selection acting on loci regulating flowering. Conclusions: Wild emmer can serve as a good source for novel APR and seedling R genes for stripe rust resistance. APR for stripe rust is a complex trait conferred by several loci that may have an additive effect. GWAS is feasible in the wild emmer population, however, its detection power is limited. A panel of wild emmer tagged with more than 150K SNP is available for further GWAS of important traits. The insights gained by the bioclimatic-gentic associations should be taken into consideration when planning conservation strategies.