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Articoli di riviste sul tema "551.480 11":
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Jäger, Ralf, Martin Purpura, Jaci Davis, Nikolas Keratsopoulos, Mandy E. Parra, Ariane H. Secrest, Grant M. Tinsley e Lem Taylor. "Glycoprotein Matrix Zinc Exhibits Improved Absorption: A Randomized Crossover Trial". Nutrients 16, n. 7 (30 marzo 2024): 1012. http://dx.doi.org/10.3390/nu16071012.
Abstract (sommario):
Biotransformation of minerals via glycosylation by microorganisms such as yeast and/or probiotics yields nutrients bound to a food matrix, resulting in increased bioavailability. The purpose of this study was to compare the effects of glycoprotein matrix-bound zinc (GPM) on absorption compared to inorganic zinc oxide. Sixteen participants ingested 11 mg of zinc as either GPM™ Soy-Free Zinc (GPM, Ashland, Kearny, NJ, USA) or zinc oxide (USP). Blood samples were taken at 0 (i.e., baseline), 30, 60, 90, 120, 180, 240, 300, 360, 420, and 480 min post-ingestion. GPM zinc concentrations were significantly higher at 120 min (p = 0.02; 12.4 ± 5.1 mcg/dL), 180 min (p = 0.002; 16.8 ± 5.1 mcg/dL), and 240 min (p = 0.007; 14.6 ± 5.1 mcg/dL) in comparison to USP zinc oxide. In addition, GPM zinc significantly increased iAUC by 40% (5840 ± 2684 vs. 4183 ± 1132 mcg/dL * 480 min, p = 0.02), and Cmax values were 10% higher in GPM compared to USP (148 ± 21 mcg/dL vs. 135 ± 17.5 mcg/dL, p = 0.08). Tmax was 12% slower in GPM compared to USP (112.5 ± 38.7 min vs. 127.5 ± 43.1 min); however, differences in Tmax failed to reach statistical significance (p = 0.28). Zinc bound to a glycoprotein matrix significantly increased absorption compared to zinc oxide.
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Ortiz-Moreno, Martha Lucia, Jaleydi Cárdenas-Poblador, Julián Agredo e Laura Vanessa Solarte-Murillo. "Modeling the effects of light wavelength on the growth of Nostoc ellipsosporum". Universitas Scientiarum 25, n. 1 (6 maggio 2020): 113–48. http://dx.doi.org/10.11144/javeriana.sc25-1.mte.
Abstract (sommario):
Mathematical models provide information about population dynamics under different conditions. In the study, four models were evaluated and employed to describe the growth kinetics of Nostoc ellipsosporum with different light wavelengths: Baranyi-Roberts, Modified Gompertz, Modified Logistic, and Richards. N. ellipsosporum was grown in BG-11 liquid medium for 9 days, using 12 hours of photoperiod and the following treatments: white light (400-800 nm), red light (650-800 nm), yellow light (550-580 nm) and blue light (460-480 nm). Each experiment was performed in triplicate. The optical density (OD) was measured on days 1, 3, 5, 7 and 9, using a spectrophotometer at 650 nm. The maximum cell growth was obtained under white light (OD650 : 0.090 ± 0.008), followed by the yellow light (OD650 :0.057 ± 0.004). Conversely, blue light showed a marked inhibitory effect on the growth of N. ellipsosporum (OD650 : 0.009 ± 0.001). The results revealed that the Baranyi-Roberts model had a better fit with the experimental data from N. ellipsosporum growth in all four treatments. The findings from this modeling study could be used in several biotechnological applications that require the productionof N. ellipsosporum and its bioproducts.
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Kantarjian, Hagop M., Richard A. Larson, Francois Guilhot, Stephen G. O’Brien e Brian J. Druker. "Declining Rates of Adverse Events (AEs), Rare Occurrence of Serious AEs (SAEs), and No Unexpected Long-Term Side Effects at 5 Years in Patients with Newly Diagnosed Chronic Myeloid Leukemia (CML) in Chronic Phase (CP) Initially Treated with Imatinib (IM) in the International Randomized Study of Interferon vs STI571 (IRIS)." Blood 108, n. 11 (1 novembre 2006): 2136. http://dx.doi.org/10.1182/blood.v108.11.2136.2136.
Abstract (sommario):
Abstract The IRIS trial compared interferon alfa + cytarabine (IFN+Ara-C) and imatinib (IM) in patients (pts) with newly diagnosed CML-CP. Among 553 pts randomized to receive 400 mg IM, 157 (28%) discontinued for reasons which included AEs or deaths unrelated to CML and treatment (6%) and unsatisfactory therapeutic effect (11%). Only 2.4% discontinued due to drug-related AEs. The average daily dose was 389±71 mg, suggesting that no major dose modifications were required due to toxicity. In pts still on IM, the average doses was 382±50 mg. Average duration of exposure is 50 mos (median 60 mos). Table 1 summarizes the most frequently reported non-hematologic AEs (regardless of relationship to study drug) in pts who started IM therapy and those who were still on IM at 2 and 4 years (n=456 and 409 respectively). Table 1. AEs (≥ 20%) on First-Line Imatinib Therapy AE All grades N= 551 (%) All grades, after 2 yrs N = 456 (%) All grades, after 4 yrs N = 409 (%) Grades 3/4 N= 551 (%) Fluid retention 61.7 20.2 5.6 2.5 – Superficial edema 59.9 18.2 5.1 1.5 – Other fluid retention events 6.9 2.4 0.7 1.3 Nausea 49.5 15.4 3.4 1.3 Muscle cramps 49.2 22.8 7.3 2.2 Musculoskeletal pain 47.0 20.8 6.1 5.4 Diarrhea 45.4 23.0 5.1 3.3 Rash and related terms 40.1 13.8 2.4 2.9 Fatigue 38.8 11.4 2.9 1.8 Headache 37.0 12.1 3.4 0.5 Abdominal pain 36.5 15.4 3.4 4.2 Joint pain 31.4 9.2 2.0 2.5 Nasopharyngitis 30.5 14.3 3.7 0 Hemorrhage 28.9 14.3 5.1 1.8 Myalgia 24.1 4.6 1.5 1.5 Vomiting 22.5 9.2 3.7 2.0 Upper respiratory tract infection 21.2 11.2 2.7 0.2 Cough 20.0 7.7 3.4 0.2 Hematologic toxicities were the most frequently occurring grade 3/4 AEs (Table 2). Table 2. Grade 3/4 laboratory abnormalities on First-line Imatinib Overall N = 551 (%) After 2 years N= 456 (%) After 4 years N= 409 (%) Hematologic – Neutropenia 16.7 7 1.0 – Thrombocytopenia 8.9 1.5 0.2 – Anemia 4.4 1.8 0.5 Biochemical – ↑ SGOT/SGPT 5.3 0.4 0 – ↑Total bilirubin 1.1 0.4 0.2 The most frequent reported AEs as well as grade 3/4 hematological and biochemical toxicities were observed at decreasing frequencies throughout therapy. After 4 years, 8% of pts experienced an SAE, compared with 14%, 12%, 7.5%, and 9% during year one through four of therapy. Overall, only 6% of pts had SAEs considered related to study drug (1.5% pts after 4 years of IM). Congestive heart failure/cardiac dysfunction (incl. pulmonary edemas) were reported for 3% of pts (<1% grade 3/4) and pleural effusion in 1% (<1% grade 3/4). Despite much shorter average exposure (12 mos), similar % of these AEs were noted for IFN+Ara-C. Although it should be considered that pts more likely to experience grade 3/4 events may have discontinued from the study prematurely, the 5-year data with IM in pts with newly diagnosed CML-CP show declining frequencies of AEs and SAEs over time. Occurrence of SAEs and laboratory abnormalities with long-term follow-up was rare. No unexpected long-term side effects were noted. These results confirm the IM tolerability and safety profile for durations exceeding 4 years.
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Saputra, Ihsan, Nugroho Pratomo Ariyanto e Mikie Febri. "Pengaruh Temperatur Tempering Terhadap Pembentukan Struktur Mikro Dan Kekerasan Baja Skd 11 Untuk Tool Steel". Jurnal Teknologi dan Riset Terapan (JATRA) 2, n. 1 (30 giugno 2020): 10–13. http://dx.doi.org/10.30871/jatra.v2i1.1787.
Abstract (sommario):
SKD 11 steel is a tool steel which is often applied in the manufacturing industry, such as cutting, punching, stamping tools, shear blades, dies and others. And in it’s application, of course steel must have a hard structure, strong and touhgness affected due to external forces causing deformation or change in shape. To improve the quality, heat treatment is required on the steel by providing austenizing, quenching and tempering temperature variations 400 °C, 550 °C and 650 °C. Which purpose to determine the hardness and microstructure of the tempering variation results. The first step of cutting material SKD 11 steel, followed by austenizing process up to 1050 °C and then quenching process (fast cooling) with medium water and continue the process of tempering variation 400 °C, 550 °C and 650 °C. After the heat treatment was complete, take hardness test and view the microstructure of the SKD 11 steel. At temperatures tempering 400 °C showed the highest hardness value of 56.5 HRC, followed by tempering temperatures 550 °C at 52.9 HRC and the lowest occurred at temperature tempering 650 °C at 39.1 HRC. Microstructure formed pearlite and martensite. Then the higher temperature tempering then the declining value of steel hardness SKD 11.
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Peng, Kuan, Dang Quan Zhang e Huai Yun Zhang. "550°C-Based Py-GC/MS Analysis of Chemical Components of Benzene/Ethanol Extractives from Trunk Bark of Cinnamomum camphora". Key Engineering Materials 480-481 (giugno 2011): 496–501. http://dx.doi.org/10.4028/www.scientific.net/kem.480-481.496.
Abstract (sommario):
Researches about the analysis and identificaion of chemical components of old bark from Cinnamomum camphora trunk were very less. Therefore, 550 °C-based pyrolysis- GC/MS technology was used to identify the top value-added biomedical constituents of old bark-based benzene/ethanol extractives from C. camphora trunk. 107 chemical constituents representing 99.316% were identified from 120 peaks. The main components are as: 1-Nonadecene (6.313% from two peaks), Octacosane (5.749% from two peaks), Octacosanoic acid, methyl ester (4.706%), 9-Tricosene, (Z)- (4.273% from seven peaks), 2-Methoxy-4-vinylphenol (2.385% from three peaks), Pyridine-3-carboxamide, oxime, N-(2-trifluoromethylphenyl)- (2.320% from three peaks), 25-Noroleana-9,12-dien-29-oic acid, 5-methyl-11-oxo-, (18.alpha.)- (2.165%), Cyclotriacontane (2.117%), Nonacosane (1.947%), 2-Pentene, (E)- (1.933%), Octadecane (1.932% from two peaks), Octacosane (1.898%), Hexacosanoic acid, methyl ester (1.861%), 1,2-Benzenedicarboxylic acid, butyl 2-methylpropyl ester (1.849%), Tetracosanoic acid, methyl ester (1.774%), 1-Hexene (1.742), Cyclotetracosane (1.719%), Hexadecane (1.435% from two peaks), etc. The result of functional analysis suggested that the 550 °C pyrolyzate of benzene/ethanol extractives from C. camphora old bark is abundant in biomedical constituents and other bioactive components, which can be used as top value-added materials of high-grade cosmetic, food, spice and chemical solvents.
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Kozlov, V. K., M. Sh Garifullin, A. Kh Sabitov e R. A. Giniatullin. "FLUORESCENT PROPERTIES OF PAPER INSULATION OF OIL-FILLED TRANSFORMERS". Proceedings of the higher educational institutions. ENERGY SECTOR PROBLEMS 20, n. 11-12 (27 febbraio 2019): 144–51. http://dx.doi.org/10.30724/1998-9903-2018-20-11-12-144-151.
Abstract (sommario):
The effect of paper thermal destruction on its luminescence spectra and luminescence excitation spectra in the spectral ranges of 400-550 nm and 250-450 nm, respectively, was studied. It is proposed to use the characteristic changes in the intensity and shape of the luminescence spectra as a criterion for the state of paper insulation of power transformers. On the basis of the analysis performed, it was concluded that when luminescence is excited at a wavelength of 360 nm, none of the main components of the paper can contribute to the recorded luminescence spectra. It is assumed that the resulting luminescence spectra are due to the emission of various impurities that enter the paper during its production.
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Gabey, A. M., W. R. Stanley, M. W. Gallagher e P. H. Kaye. "The fluorescence properties of aerosol larger than 0.8 μm in an urban and a PBA-dominated location". Atmospheric Chemistry and Physics Discussions 11, n. 1 (7 gennaio 2011): 531–66. http://dx.doi.org/10.5194/acpd-11-531-2011.
Abstract (sommario):
Abstract. Dual-wavelength Ultraviolet light-induced fluorescence (UV-LIF) measurements were performed on ambient environmental aerosol in Manchester, UK (urban city centre, winter) and Borneo, Malaysia (remote, tropical), which are taken to represent environments with negligible and significant primary biological aerosol (PBA) influences, respectively. Single-particle fluorescence intensity and optical equivalent diameter were measured with a Wide Issue Bioaerosol Sensor, version 3 (WIBS3) in the diameter range 0.8 μm≤DP≤20 μm for 2–3 weeks and filters were analysed using energy dispersive X-ray (EDX) spectroscopy, which revealed mostly non-PBA dominated particle sizes larger than 1 μm in Manchester. The WIBS3 features three fluorescence channels: Fluorescence excited at 280 nm is recorded at 310–400 nm and 400–600 nm and fluorescence excited at 370 nm is detected at 400–600 nm. In Manchester the primary size mode of fluorescent and non-fluorescent material was at 1.2 μm. In Borneo non-fluorescent material peaked at 1.2 μm and fluorescent at 3–4 μm. The fluorescence intensity at 400–600 nm generally increased with DP at both sites, as did the 310–400 nm intensity in Borneo. In Manchester the 310–400 m fluorescence decreased at DP>4 μm, suggesting this channel offers additional discrimination between fluorescent particle types. Finally, the ratio of fluorescence intensity in two pairs of channels was investigated as a function of particle diameter and this varied significantly between the two environments, demonstrating that the fluorescent aerosol in each can in principle be distinguished using a combination of fluorescence and elastic scattering measurements.
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Prokopenko, A. A., E. V. Bezrukova, G. K. Khursevich, E. P. Solotchina, M. I. Kuzmin e P. E. Tarasov. "Climate in continental interior Asia during the longest interglacial of the past 500 000 years: the new MIS 11 records from Lake Baikal, SE Siberia". Climate of the Past 6, n. 1 (20 gennaio 2010): 31–48. http://dx.doi.org/10.5194/cp-6-31-2010.
Abstract (sommario):
Abstract. A synthesis of paleoclimate responses from Lake Baikal during the MIS 11 interglacial is presented based on proxy records from two drill sites 245 km apart. BDP-99 is located in vicinity of the delta of the major Baikal tributary, whereas the BDP-96 site represents hemipelagic setting distant from riverine influence. The comparison of thicknesses of interglacial intervals in these contrasting depositional settings confirms the extended ca. 33-kyr duration of the MIS 11 interglacial. The new BDP-99 diatom biostratigraphic record matches that of the BDP-96-2 holostratotype and thus allows establishing establishes robust correlation between the records on the same orbitally-tuned timescale. The first detailed MIS 11 palynological record from the BDP-99 drill core indicates the dominance of boreal conifer (taiga) forest vegetation in the Baikal region throughout the MIS 11 interglacial, since at least 424 ka till ca. 396 ka. The interval ca. 420–405 ka stands out as a "conifer optimum" with abundant Abies sibirica, indicative of climate significantly warmer and less continental than today. The closest Baikal analog to this type of vegetation in the history of the current Holocene interglacial is at ca. 9–7 ka. The warm conifer phase lasted for ca. 15 kyr during MIS 11 interrupted by two millennial-scale cooling episodes at ca. 411–410 and 405–404 ka. Reconstructed annual precipitation of 450–550 mm/yr during the MIS 11 interglacial is by ca. 100 mm higher than during the Holocene; regional climate was less continental with warmer mean temperatures both in summer and in winter. At both drill sites, the two-peak structure of the MIS 11 diatom abundance profiles reflects the orbital signature of precession in the interglacial paleoclimate record of continental Eurasia. MIS 11 interglacial was characterized by the sustained high level of primary production and accumulation of autochthonous organic matter at both study sites. The responses of paleoclimate-sensitive indices in the mineralogy of the MIS 11 sediments in BDP-96-2 are consistent with those during the Holocene. Illitization of secondary clay minerals in the Baikal watershed was an important process, but it appears to have been subdued during the first half of the MIS 11, apparently due to elevated humidity and muted seasonality of regional climate.
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Wang, H., X. Liu, K. Chance, G. Gonzalez Abad e C. Chan Miller. "Water vapor retrieval from OMI visible spectra". Atmospheric Measurement Techniques Discussions 7, n. 1 (22 gennaio 2014): 541–67. http://dx.doi.org/10.5194/amtd-7-541-2014.
Abstract (sommario):
Abstract. There are distinct spectral features of water vapor in the wavelength range covered by the Ozone Monitoring Instrument (OMI) visible channel. Although these features are much weaker than those at longer wavelengths, they can be exploited to retrieve useful information about water vapor. They have an advantage in that their small optical depth leads to fairly simple interpretation as measurements of the total water vapor column density. We have used the Smithsonian Astrophysical Observatory (SAO)'s OMI operational retrieval algorithm to derive the Slant Column Density (SCD) of water vapor from OMI measurements using the 430–480 nm spectral region after extensive optimization of retrieval windows and parameters. The Air Mass Factor (AMF) is calculated using look-up tables of scattering weights and monthly mean water vapor profiles from the GEOS-5 assimilation products. We convert from SCD to Vertical Column Density (VCD) using the AMF and generate associated retrieval averaging kernels and shape factors. Our standard water vapor product has a median SCD of ~ 1.3 × 1023 molecule cm−2 and a median relative uncertainty of ~ 11% in the tropics, about a factor of 2 better than that from a similar OMI algorithm but using narrower retrieval window. The corresponding median VCD is ~ 1.2 × 1023 molecule cm−2. We have also explored the sensitivities to various parameters and compared our results with those from the Moderate-resolution Imaging Spectroradiometer (MODIS) and the Aerosol Robotic NETwork (AERONET).
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Ben salem, N., A. Belghith, Z. Ben zina, M. Dhouib, A. Mallek, A. Mnif, F. Karray, H. Ben Amor e M. Abdelmoula. "440 Les fractures du plancher de l’orbite de type « blow-out » pur : à propos de 11 cas". Journal Français d'Ophtalmologie 30 (aprile 2007): 2S278. http://dx.doi.org/10.1016/s0181-5512(07)80253-1.
Tesi sul tema "551.480 11":
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Sant, anna Elcio. "CRIAÇÃO E RECRIAÇÕES COSMOGÔNICAS EM ISAÍAS 51, 9-11: Um estudo do uso do mito cosmogônico pelo Dêutero-Isaías para o entendimento da comunidade dos cativos judaítas em Babilônia". Universidade Metodista de São Paulo, 2007. http://tede.metodista.br/jspui/handle/tede/440.
Abstract (sommario):
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Elcio Santanna.pdf: 407166 bytes, checksum: a93d8e2adb8a6ac95ce33860c3e3dd92 (MD5)
Previous issue date: 2007-09-10Conselho Nacional de Desenvolvimento Científico e Tecnológico
How should a culture or a lost community in biblical times be studied? This is a compelling issue for the author. This is how his interest in discussing the possibility of the use of the cosmogonic myth for the understanding of the community of the captives in Babylon appeared. An initiative which needed to be tracked by researchers who could be available for the study of the cultures of the biblical world. The topic the cosmogonic myth in the First Testament as an instrument to deepen the biblical research was thus elected. The myth is kind of an obvious choice for its capacity of functioning as a paradigm, pragmatic and traditive counter hegemonic within a social interethnic context. These were ponderings which came from the matrices such as those from the phenomenologist Mircea Eliade, from de Anthropologist Roger Bastide and from the theologist and phenomenologist José Severino Croatto. This is the reason why a parallel is traced between the myth of Marduk and the text of Isaiah 51,9-11 which talks about Javé as the creator of the world and the one who fights against forces of the chaos. This is done at the sight of the perception of the prophecy of Isaiah from exile, as a relative and its juxtaposition with the Babylonian mythology, and both approach enough in a syntagmatic and historical social way. Yet it had to be clarified, if the prophecy of the Deutero Isaiah acted in the same way as the poem Enuma elish worked for the Babylonians. This means that social patterns were caused to appear to the slaves communities inside the Neo Babylonian empire; in these chants, the captives managed to build an orderliness for their communities which enjoyed a certain autonomy such as colonies and ghettos ; if owning this daring prophecy, the Jews of the golah were able to elaborate a civil disobedience in terms of nourishing in the hearts, an Utopia which would break up with the status quo of the past, committing them with the hope in Javé the Creator(AU)
Como estudar uma cultura ou uma comunidade perdida nos tempos bíblicos? Esta é um questão motriz para o autor. Foi dessa maneira que surgiu o seu interesse em discutir a possibilidade do uso do mito cosmogônico para o entendimento da comunidade dos cativos judaítas em Babilônia. É uma iniciativa, que precisava ser trilhada pelos pesquisadores que se dispusessem ao estudo das culturas do mundo bíblico. Assim se elegeu o tema Mito Cosmogônico no Primeiro Testamento como instrumento de aprofundamento da pesquisa bíblica. O mito é uma escolha mais ou menos óbvia, pela sua capacidade de funcionar como paradigma, pragmática e traditiva contra-hegemônica dentro de um contexto social interétnico. Estas eram ponderações vindas de matrizes como a do fenomenólogo Mircea Eliade, do Antropólogo Roger Bastide e do teólogo e fenomenólogo José Severino Croatto. É por isto que um paralelo é traçado entre o mito de Marduk e o texto de Isaías 51, 9-11, que fala de Javé como sendo criador do mundo e que luta contra as forças do caos. Isto é feito, com vistas à percepção da profecia do Isaías do exílio, como parentesco e sua justaposição com a mitologia babilônica, e ambos se aproximam bastante de forma sintagmática e histórico-social. Coube ainda saber se a profecia do Dêutero-Isaías atuava da mesma maneira que o poema Enuma elish funcionava para os babilônicos. Ou seja, fazia-se surgir modelos sociais às comunidades de escravos dentro do Império Neobabilônico; se com base nestes cânticos, os cativos conseguiam construir um ordenamento para as suas comunidades, que gozavam de uma relativa autonomia, tais como colônias e guetos ; se de posse dessa ousada profecia, os judeus da golah eram capazes de elaborar uma desobediência cívil nos termos de um nutrir nos corações, uma utopia que rompesse com o status quo do passado, comprometendo-os com a esperança no Javé criador.(AU)
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Sachse, Anna. "Mechanistische Einblicke in die Aktivierung bimetallischer Präkatalysatoren für die Norbornenpolymerisation: Multinukleare Übergangsmetallkomplexe der Gruppen 9-11 mit a-Diimin Pyrazolatliganden". Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-ACC8-1.
Libri sul tema "551.480 11":
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Báez Daza, Eliana Yadira, Genaro Andrés Agudelo Castañeda, Lucero Gertrudis Rodriguez Silva, Roberto Antonio Coronado Silva, Luis Javier López Giraldo e Karen Stephanie Núñez Gómez. Caracterización agronómica, fisicoquímica, sensorial y de metabolitos con actividad funcional de cacaos especiales cultivados bajo sistemas agroforestales en el departamento de Santander. Corporación Colombiana de Investigación Agropecuaria (Agrosavia), 2022. http://dx.doi.org/10.21930/agrosavia.investigation.7405309.
Abstract (sommario):
En el presente documento se hace una compilación de información producto de resultados de investigación cuyo objetivo principal fue la caracterización agronómica fisicoquímica, funcional y análisis sensorial de 22 genotipos regionales denominados TCS 01, 02, 04, 05, 06, 08, 10, 11, 12, 13, 19, 20, 40, 41, 42, 44, 45, 46, 47, 48 y 49, los cuales son producto de selección natural participativa, y el material TCS 03 que es producto de cruzamiento, así como la evaluación de dos genotipos introducidos y comercialmente distribuidos a nivel nacional ICS 95 y CCN 51. Esta evaluación fue ejecutada por el equipo científico y técnico de AGROSAVIA, en el Centro de Investigación La Suiza y la Universidad Industrial de Santander, desde el Laboratorio de Alimentos del CICTA encontrándose como resultado que los genotipos en estudio presentan un comportamiento productivo y sanitario de interés comercial (TCS 06, 01, 11, 13, 03 y 49), así como un potencial en su composición funcional (TCS 01, 04, 06, 13 y 47) y atributos sensoriales (TCS 01, 02, 05, 13, 19 y 06) además se desarrolló un modelo de predicción de perfiles. Toda la información consignada en este manuscrito sirve como base para investigadores, gremios, industriales, agricultores y comunidad académica, en la evaluación de nuevos genotipos de interés y ratificar a Colombia como país productor de cacao fino y aromatizado reconocido por la International Cocoa Organization (ICCO).
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Lee, Jongkyung. A Redactional Study of the Book of Isaiah 13-23. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198816768.001.0001.
Abstract (sommario):
This study argues that a series of programmatic additions were made to the oracles concerning the nations in Isa 13-23 during the late-exilic period by the same circle of writers who were responsible for Isa 40-55. These additions were made to create continuity between the ancient oracles against the nations from the Isaiah tradition and the future fate of the same nations as the late-exilic redactor(s) foresaw. The additions portray a two-sided vision concerning the nations. One group of passages (14:1-2; 14:32b; 16:1-4a; 18:7) depicts a positive turn for certain nations while the other group of passages (14:26-27; 19:16-17; 23:8-9, 11) continues to pronounce doom against the remaining nations. This double-sided vision is set out first in Isa 14 surrounding the famous taunt against the fallen tyrant. 14:1-2, before the taunt, paints the broad picture of the future return of the exiles and the attachment of the gentiles to the people of Israel. After the taunt and other sayings of YHWH against his enemies, 14:26-27 extends the sphere of the underlying theme of 14:4b-25a, namely YHWH’s judgement against boastful and tyrannical power(s), to all nations and the whole earth. The two sides of this vision are then applied accordingly to the rest of the oracles concerning nations in chs 13-23. To the nations that have experienced similar disasters as the people of Israel, words of hope in line with 14:1-2 were given. To the nations that still possessed some prominence and reasons to be proud, words of doom in line with 14:26-27 were decreed.
Capitoli di libri sul tema "551.480 11":
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Theisen-Womersley, Gail. "Prevalence of PTSD Among Displaced Populations—Three Case Studies". In Trauma and Resilience Among Displaced Populations, 67–82. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67712-1_3.
Abstract (sommario):
AbstractAs explored in chapter two, displaced populations face a myriad of traumatic events, throughout the migration process. It comes as no surprise than, that two landmark, systematic meta-reviews found prevalence rates among refugee populations of 40% (Turrini et al., .International Journal of Mental Health Systems 11:51, 2017) and 30.6% (Steel et al., .JAMA 302:537–549, 2009) respectively.
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Eliava, Shalva, Vadim Gorozhanin, Oleg Shekhtman, Yuri Pilipenko e Olga Kuchina. "Surgical Treatment of Unruptured Brain AVMs: Short- and Long-Term Results". In Acta Neurochirurgica Supplement, 87–90. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63453-7_13.
Abstract (sommario):
AbstractUnruptured brain AVMs (bAVMs) remain a controversial subject for practicing neurosurgeons, especially in the light of ARUBA and other observational studies. This retrospective study aims to analyze our experience with unruptured bAVMs to see whether it is beneficial in the long-term and how it corresponds to large literature trials. The study comprised 160 adult patients with unruptured bAVMs surgically treated in Burdenko NMC (Moscow) in 2009–2017. Mean age: 33.4 ± 10лет. Clinical presentations were: seizures in 99 (61.9%), chronical headaches—49 (30.6%), ischemic symptoms—4 (2.5%), asymptomatic in 8 (5%) patients. Spetzler-Martin scale: I—18 pt. (11.3%), II—71 pt. (44.4%), III—60 pt. (37.5%), IV—11 pt. (6.8%). Good outcomes (mRS = 0–2) at discharge were achieved in 149 (93.1%), satisfactory (mRS—3)—9 (5.6%). Follow-up was complete for 97 (60.6%) patients, mean—59.3 (13–108 month). Excellent outcomes (mRS = 0–1) reached in 94.8%. For epilepsy patients, Engel I outcome was found in 50 (84.8%); for chronic headaches, 43 (66.1%) patients reported improvement. Postoperative visual field defects were followed in 22 of 55 (40%), complete recovery was reported in 6 (27%) and partial recovery in 8 (36%) patients. Overall, our results support the conclusion that surgery for low-grade bAVMs (S-M I–II) is a beneficial, low-risk option.
3
van der Lugt, Pieter. "Prologue: Isaiah 40,1–11". In The Rhetorical Design of Isaiah 40-48/55, 31–65. BRILL, 2022. http://dx.doi.org/10.1163/9789004514768_003.
4
Jianlong, Yu, e Cao Lijun. "11 Arbitral Awards: (Articles 48 to 55)". In A Guide to the CIETAC Arbitration Rules. Oxford University Press, 2020. http://dx.doi.org/10.1093/law/9780199671717.003.0011.
Abstract (sommario):
This chapter explores the various issues in relation to arbitral awards under the CIETAC Rules. These issues include: the types of awards (Articles 49 and 50); the time period for rendering an award (Article 48); the making of an award (Article 49); the scrutiny of a draft award (Article 51); the allocation of costs (Article 52); correction of an award (Article 53); an additional award (Article 54); and performance of an award (Article 55). Arbitral awards are written decisions of an arbitral tribunal dealing with substantive matters in dispute and which have been submitted to arbitration. Under the CIETAC Rules, the arbitral tribunal may make the following types of awards: (1) partial award and interlocutory award; (2) consent award; and (3) final award. As set forth in Article 48.1, a final award shall be rendered within six months from the date on which the arbitral tribunal was constituted. Under Article 51, arbitrators are required to submit a draft award to the CIETAC for review before finalizing the award. The purpose of this scrutiny mechanism is to ensure the quality of arbitral awards.
5
Popova, Olga. "A Greek Gospel from the sacristy of the Trinity Lavra of St. Sergius no. 28 (Greek 11)". In Vertograd multicoloured: dedicated to the eightieth anniversary of Boris N. Florya, 19–36. Indrik, 2018. http://dx.doi.org/10.31168/91674-483-5.1.
6
Bygrave, Lee A., e Luca Tosoni. "Article 4(11). Consent". In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0017.
Abstract (sommario):
Article 5 (Principles relating to processing of personal data) (see also recitals 33, 39 and 50); Article 6(1)(a) (Lawfulness of processing on basis of consent) (see too recital 40); Article 7 (Conditions for consent) (see also recital 42); Article 8 (Conditions applicable to child’s consent in relation to information society services) (see too recital 38); Article 9(2)(a) (Processing of special categories of personal data on basis of consent) (see too recital 51); Article 13 (Information to be provided where personal data are collected from the data subject) (see too recitals 60–62); Article 14 (Information to be provided where personal data have not been obtained from the data subject); Article 17 (Right to erasure) (see too recital 65); Article 20 (Right to data portability) (see too recital 68); Article 22 (Automated individual decision-making, including profiling) (see too recital 71); Article 49(1)(a) (Transfer of personal data to third country or international organisation on basis of consent) (see too recitals 111–112).
7
Taber, Douglass. "Synthesis of Heteroaromatics". In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0066.
Abstract (sommario):
Yasutaka Ishii of Kansai University has developed (J. Org. Chem. 2007, 72, 8820) a novel route to furans, using a mixed-metal catalyst to effect condensation of an aldehyde or 1,3 diketone such as 1 with an acceptor such as 2 to give the 3-furoate 3. In a complementary approach, Yong-Min Liang of Lanzhou University has found (J. Org. Chem. 2007, 72, 10276) that diazoacetate 5 will condense with an alkynyl ketone to give the 2-furoate 6. David W. Knight of Cardiff University has shown (Tetrahedron Lett. 2007, 48, 7709) that an alkynyl diol such as 7, readily available by dihydroxylation of the corrresponding alkenyl alkyne, cyclized to the furan on exposure to AgNO3 on silica gel. Professor Knight has also (Tetrahedron Lett. 2007, 48, 7906) established a route to poly-substituted pyrroles 10, by iodination of alkynyl sulfonamides such as 9. Similarly, Richard C. Larock of Iowa State University found (J. Org. Chem. 2007, 72, 9643) that I-Cl cyclized methoximes such as 11 to the corresponding iodo isoxazole 12, and Stephen L. Buchwald of MIT uncovered (Organic Lett. 2007, 9, 5521) the cyclization of an enamide such as 13 with I2 to the corresponding oxazole 14. In developing a more efficient route to a new class of materials that he has named “triazolamers”, Paramjit S. Arora of New York University was able (J. Org. Chem. 2007, 72, 7963) to effect diazo transfer to the amine 15 and subsequent condensation with 16 to give 17, without isolation of the intermediate azide. C. V. Asokan and E. R. Anabha of Mahatma Gandhi University have described (Tetrahedron Lett. 2007, 48, 5641) the activation of a ketone 18 followed by condensation with malononitrile 19 to give the pyridine 20. Hans-Ulrich Reissig of the Freie Universität Berlin has established (Organic Lett. 2007, 9, 5541) a complementary three-component coupling of a nitrile 21 with the allenyl anion 22, followed by a carboxylic acid 23 to deliver the pyridine 24. Akio Saito and Yuji Hanzawa of the Showa Pharmaceutical University have reported (Tetrahedron Lett. 2007, 48, 6852) the intramolecular Rh-catalyzed cyclization of a methoxime lactone such as 25 to the pyridine 26.
8
Taber, Douglass F. "Alkene and Alkyne Metathesis: Navenone B (Cossy), (+)-Asperpentyn (Daesung Lee), (-)-Amphidinolide K (Eun Lee), Norhalichondrin B (Phillips)". In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0031.
Abstract (sommario):
A variety of antibiotics and immune-suppressive agents contain extended arrays of all- ( E )-polyenes. Samir Bouzbouz of CNS Rouen and Janine Cossy of ESPCI ParisTech devised ( Synlett 2009, 803) a simple iterative route to polyacetates such as 1 and demonstrated that after cross-metathesis, elimination, in this case to give Navenone B 3, was facile. Both ketones and esters can promote the elimination. Daesung Lee of the University of Illinois at Chicago designed (Organic Lett. 2009, 11 , 571) a clever chain-walking ring-closing ene-yne metathesis, cyclizing 4 to 5. Deprotection led to (+)-asperpentyn 6. This should be a general entry to such polyoxygenated cyclohexenes. For the structures of H2 and G2, see Organic Highlights, September 13, 2004. One of the challenges in the synthesis of (-)-amphidinoloide K 10 is the assembly of the complex conjugated diene. Eun Lee of Seoul National University found (Angew. Chem. Int. Ed. 2009, 48, 2364) a solution to this problem in the Ru-catalyzed cross-metathesis between the alkyne 7 and the alkene 8. Note that the cross-metathesis proceeded with high regioselectivity and with substantial (7.5:1) control of the product alkene geometry. For the construction of complex natural products such as norhalichondrin B 14, it is important to employ a convergent synthetic strategy. For this to be successful, efficient methods for convergent coupling are required. In the course of a synthesis of 14, Andrew J. Phillips of the University of Colorado showed (Angew. Chem. Int. Ed. 2009, 48, 2346) that Ru-mediated cross-metathesis could be used to couple the enone 11 with the alkene 12. A less congested version of H2, designed by Robert H. Grubbs of Caltech, was used for the coupling. The electron-deficient alkene of 11 and the more electron-rich alkene of 12 made a matched set, promoting the cross-coupling. Note again, in this context, the desirability of leaving the allylic alcohol of 12 unprotected to facilitate Ru-catalyzed alkene cross-metathesis.
9
Jakob, Carolin E. M., Melanie Stecher, Sandra Fuhrmann, Sebastian Wingen-Heimann, Stephanie Heinen, Gabriele Anton, Michael Behnke et al. "Needs for an Integration of Specific Data Sources and Items – First Insights of a National Survey Within the German Center for Infection Research". In German Medical Data Sciences: Bringing Data to Life. IOS Press, 2021. http://dx.doi.org/10.3233/shti210075.
Abstract (sommario):
State-subsidized programs develop medical data integration centers in Germany. To get infection disease (ID) researchers involved in the process of data sharing, common interests and minimum data requirements were prioritized. In 06/2019 we have initiated the German Infectious Disease Data Exchange (iDEx) project. We have developed and performed an online survey to determine prioritization of requests for data integration and exchange in ID research. The survey was designed with three sub-surveys, including a ranking of 15 data categories and 184 specific data items and a query of available 51 data collecting systems. A total of 84 researchers from 17 fields of ID research participated in the survey (predominant research fields: gastrointestinal infections n=11, healthcare-associated and antibiotic-resistant infections n=10, hepatitis n=10). 48% (40/84) of participants had experience as medical doctor. The three top ranked data categories were microbiology and parasitology, experimental data, and medication (53%, 52%, and 47% of maximal points, respectively). The most relevant data items for these categories were bloodstream infections, availability of biomaterial, and medication (88%, 87%, and 94% of maximal points, respectively). The ranking of requests of data integration and exchange is diverse and depends on the chosen measure. However, there is need to promote discipline-related digitalization and data exchange.
10
Taber, Douglass F. "Organocatalytic C–C Ring Construction: Prostaglandin F2α (Aggarwal)". In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0072.
Abstract (sommario):
Marco Lombardo of the Università degli Studi di Bologna devised (Adv. Synth. Catal. 2012, 354, 3428) a silyl-bridged hydroxyproline catalyst that mediated the enantioselective addition of 2 to cinnamaldehyde 1 to give 3. Yoann Coquerel and Jean Rodriguez of Aix Marseille Université showed (Adv. Synth. Catal. 2012, 354, 3523) that a hybrid epi-cinchonine catalyst directed the enantioselective and diastereoselective addition of the amide 4 to the nitro alkene 5 to give 6. Magnus Rueping of RWTH Aachen observed (Angew. Chem. Int. Ed. 2012, 51, 12864) that a chiral Brønsted acid mediated the diastereoselective and enantioselective formation of 9 by the addition of 8 to cyclopentadiene 7. Marco Bandini, also of the University of Bologna, combined (Chem. Sci. 2012, 3, 2859) organocatalysis with gold catalysis to effect the cyclization of 10 to 11. Min Shi of the Shanghai Institute of Organic Chemistry prepared (Chem. Commun. 2012, 48, 2764) the quaternary cyclic amino acid derivative 14 by adding 13 to the acceptor 12. Makoto Tokunaga of Kyushu University prepared (Org. Lett. 2012, 14, 6178) the ketone 17 by the hydrolytic enantioselective protonation of the enol ester 15. Hiyoshizo Kotsuki of Kochi University developed (Synlett 2012, 23, 2554) a dual catalyst combination that effectively mediated the enantioselective addition of malonate even to the congested acceptor 18. Yoshitaka Hamashima and Toshiyuki Kan of the University of Shizuoka established (Org. Lett. 2012, 14, 6016) a protocol for the enantioselective brominative cyclization of 21, readily available by the reductive alkylation of benzoic acid. Polycarbocyclic ring systems can also be prepared by organocatalysis. Ying-Chun Chen of Sichuan University tuned (J. Am. Chem. Soc. 2012, 134, 19942) cinchona-derived catalysts to selectively convert 23 into either exo (illustrated) or endo 25. Peng-Fei Xu of Lanzhou University developed (Angew. Chem. Int. Ed. 2012, 51, 12339) a supramolecular iminium catalyst for the intramolecular Diels-Alder cycloaddition of 26. In a spectacular illustration of the power of organocatalysis, Varinder K. Aggarwal of the University of Bristol dimerized (Nature 2012, 489, 278) succinaldehyde from the hydrolysis of commercial 28 directly to the unsaturated aldehyde 29. Diastereoselective conjugate addition led to prostaglandin F2α 30.
Atti di convegni sul tema "551.480 11":
1
Abe, Fujio. "Creep Life Prediction of Gr.91 Using Creep Parameters in Transient Region". In ASME 2012 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/pvp2012-78102.
Abstract (sommario):
The creep deformation behavior and its effect on creep life have been investigated for Gr.91 by analyzing creep strain data in the NIMS Creep Data Sheet. The creep life tr is mainly determined by the minimum creep rate ε̇min, indicating tr ∝ (ε̇min)−1. The ε̇min is mainly determined by the time to minimum creep rate tm, indicating ε̇min ∝ (tm)−1. Then the creep life is correlated with the tm as tr=3.7tm, where the constant 3.7 is as an average value for a wide range of temperature (450–725 °C), stress (40–450 MPa) and test duration (11–68,755 h). Using this equation, we can predict the creep life by carrying out a short-term creep test for up to the end of transient region, corresponding to about 30% of creep life. The (tm/tr), the ratio of duration of transient region to the creep life, slightly decreases with decreasing stress and is evaluated to be 0.22 at 100 MPa and above 550 °C, which gives us tr= 4.5 tm at 100 MPa. Taking the stress dependence of the (tm/tr) into account, the accuracy of creep life prediction is further improved.
2
Madic, Milomirka, Dalibor Tomic, Aleksandar Paunovic, Vladeta Stevovic e Dragan Đurovic. "PRINOS ZRNA HIBRIDA KUKURUZA RAZLIČITIH FAO GRUPA ZRENJA". In SAVETOVANJE o biotehnologiji sa međunarodnim učešćem. University of Kragujeva, Faculty of Agronomy, 2021. http://dx.doi.org/10.46793/sbt26.093m.
Abstract (sommario):
Field experiments with 11 native maize hybrids for grain production FAO maturity group 400-600 were set up over two years at two sites (near the villages of Brzan and Lužnice, Kragujevac municipality) with the aim of, based on the yield over years, recommending hybrids for specific agroecological conditions. The average maize grain yield for all hybrids in 2017 was 4.2 t ha-1, and in 2018 11.1 t ha-1. Hybrids ZP 548 and NS 5051 had the highest average grain yield in 2017, and in 2018 ZP 560 and NS 4051. Higher yields in 2018 are mainly the result of a larger amount and a more favorable distribution of precipitation in the vegetation period. In both years, which differed in agrometeorological conditions during the vegetation period, especially in the amount and distribution of precipitation in the second part of the vegetation, in which the critical phases of maize development take place, the highest yields were recorded mainly in FAO 500 hybrids.
3
Laubscher, Curt A., Ryan J. Farris e Jerzy T. Sawicki. "Design and Preliminary Evaluation of a Powered Pediatric Lower Limb Orthosis". In ASME 2017 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/detc2017-67599.
Abstract (sommario):
This paper describes the first stages of hardware development and preliminary assessment for a powered lower limb orthosis designed to provide gait assistance and rehabilitation to children with walking impairments, such as those associated with cerebral palsy and spina bifida. The design requirements, including range of motion, speeds, torques, and powers, are investigated and presented based on a target user age range of 6–11 years old. A three stage joint actuator is designed, built, and tested against the design requirements. The 0.6 kg actuator produced 4.2 Nm continuous torque and 17.2 Nm peak torque, and was able to run up to a speed of 480 deg/s. Backdrivability was characterized in terms of rotational friction, which was measured at 1.1 Nm. Finally, a 5.1 kg prototype orthosis was developed consisting of a hip segment, left and right thigh segments, and left and right shank segments, with four identical actuator prototypes installed in the thigh segments to actuate the hips and knees. Control electronics and a basic control structure were implemented to test the joint tracking capability of the orthosis against a predefined set of trajectories which were representative of pediatric gait patterns. Fitted to a dummy, the controlled limb successfully tracked the desired trajectories with a root-mean-square error of 9% and 4% of full scale for the hips and knees, respectively. With the dummy loaded with additional weight to representing a 32 kg child, the limbs also successfully tracked the trajectories with a root-mean-square error of 15% and 6% of full scale for the hips and knees, respectively.
4
Матвеева, Т. А., Л. В. Дитковская, А. В. Орлов e Л. А. Желенина. "ДИАГНОСТИКА НАРУШЕНИЙ УГЛЕВОДНОГО ОБМЕНА У ДЕТЕЙ БОЛЬНЫХ МУКОВИСЦИДОЗОМ". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-80.
Abstract (sommario):
ЦЕЛЬ: выявить частоту и оптимизировать диагностику нарушений углеводного обмена у детей больных
муковисцидозом.
МАТЕРИАЛЫ И МЕТОДЫ: обследовали 68 пациентов со смешанной формой муковисцидоза (МВ),
среди которых 9 человек – дети от 1 до 3 лет, 33 пациента от 3 до 11 лет и 26 подростков от 11 до 18 лет.
Исследовали уровень HbA1c, инсулина, с-пептида методом иммуноферментного анализа. Детям старше
3-х лет выполняли оральный глюкозотолерантный тест (ОГТТ), в ходе которого вычисляли индексы Homa
и Caro. Всем пациентам проводили суточное мониторирование глюкозы крови (CGMS – Continuous Glucose
Monitoring System). С целью выявления вариантов гена CFTR выполнили молекулярно-генетическое ис-
следование. За «тяжелые» мутации в гене CFTR принимали мутации I, II, и III класса: DF508, G542X, G551D,
R553X, W1282X, N1303K, 1677delTA, 621+1G-T, 1717-1G-A, CFTRdele2,3(21kb). Мутации IV и V классов (R117H,
3849 + 10kbC-T, R347P, T338I, G551S, отнесли к «мягким».
РЕЗУЛЬТАТЫ: нарушения углеводного обмена (НУО) были выявлены у 24 обследованных (35%), при-
чем муковисцидоз-ассоциированный сахарный диабет (МВСД) был диагностирован у 14 пациентов (21%),
нарушение толерантности к глюкозе (НТГ) диагностировано у 10 больных (15%). В группе подростков НУО
распределились следующим образом: в 38% случаев МВСД, в 23% случаев НТГ, у детей от 3 до 11 лет НТГ
в 9%, МВСД у 12%.
Средний уровень HbA1C у пациентов с МВСД составил 6,9±2,1% (от 4,2 до 9,0 %), с НТГ – 5,1±1,1%
(от 4,0 до 6,2 %), а у детей с нормальным углеводным обменом был в норме 4,7±0,75% (от 4,0 до 5,5 %).
При расчёте индексов Homa и Caro, у пациентов с НУО в 71% случаев отмечалось снижение индекса Caro
(<0.332), у детей с нормальным углеводным обменом индексы соответствовали референсным значениям.
CGMS выявило постпрандиальную гипергликемию у 53 из 68 пациентов (78%), в то время как, по резуль-
татам стандартных методов НУО диагностированы только в 35% случаев. Постпрандиальная гипергликемия
при проведении CGMS чаще регистрировалась у подростков (93%), чем у детей от 3 до 11 лет (67%).
По результатам молекулярно-генетического исследования у 48 пациентов (70,6%) были выявлены
варианты delF508 гена CFTR, причем у 19 (28%) в гомозиготном состоянии, у 29 (42,6%) в компаунде
с CFTRdele2,3(21kb), N1303K, W1282X, R334W, 2184insA, 2143delT, относящимися к «тяжелым».
Частота НУО у детей с «тяжелыми» мутациями гена CFTR составила 42%, причем все случаи МВСД были
диагностированы у пациентов данной группы.
ВЫВОДЫ:
1. У детей со смешанной формой МВ частота НУО составила 35% и была достоверно выше у подростков
(chi2=12,57; p=0,014).
2. Снижение индекса Caro (<0.332) отмечено у пациентов с МВСД и НТГ, что свидетельствует о развитии
инсулинорезистентности.
3. Использование CGMS позволяет выявить постпрандиальную гипергликемию у детей с МВ значимо чаще,
чем стандартные методы диагностики. Таким образом, проведение суточного мониторирования глюко-
зы целесообразно у больных МВ, так как дает возможность зарегистрировать скрытые гипергликемии.
4. Нарушения углеводного обмена, в том числе МВСД, чаще встречается у пациентов с «тяжелыми» мута-
циями гена CFTR.
5
Кривова, Ю. С., А. Е. Прощина, Д. А. Отлыга, В. М. Барабанов e С. В. Савельев. "БИГОРМОНАЛЬНЫЕ ЭНДОКРИННЫЕ КЛЕТКИ В ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЕ ЛЮДЕЙ С САХАРНЫМ ДИАБЕТОМ 1 ТИПА". In Сборник тезисов III Конференции по лечению и диагностике сахарного диабета «Фундаментальная и клиническая диабетология в 21 веке: от теории к практике». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/diaconfiii25-26.05.23-53.
Abstract (sommario):
ЦЕЛЬ: изучить распределение бигормональных (инсулин+/глюкагон+) клеток в поджелудочной железе
(ПЖ) людей, страдавших сахарным диабетом 1 типа (СД1).
МАТЕРИАЛЫ И МЕТОДЫ: работа выполнена на аутопсиях ПЖ ребенка (мальчик, 3 года 9 месяцев)
и подростка (мальчик, 13 лет 11 месяцев) с недавно диагностированным сахарным СД1, и 2 взрослых лю-
дей с СД1 длительностью более 15 лет (мужчины, 27 лет и 41 год). Группой сравнения послужили аутопсии
ПЖ 3 людей, не страдавших нарушениями углеводного обмена (мальчик, 4 года 9 месяцев; девочка, 8 лет;
женщина, 25 лет). Парафиновые срезы ПЖ исследованы методом иммунофлуоресцентного маркирова-
ния. Для оптимального выявления инсулина использовали и сравнивали первичные антитела различ-
ных производителей: мышиные моноклональные атитела к инсулину (Sigma, Cat.#I2018; Thermo Scientific,
Cat.#Ms-1379-P), кроличьи поликлональные антитела к инсулину (Santa Cruz Biotechnology, Cat.#Sc-9168;
Abcam, Cat.#ab63280; Golden Bridge, Cat.#P9009) и поликлональные антитела морской свинки к инсулину
(Dako, Cat.#A0564). Двойное иммунофлуоресцентное маркирование проводили с использованием мы-
шиных моноклональных антител к инсулину (Sigma и Thermo Scientific) и кроличьих поликлональных
антител к глюкагону (ThermoFisherScientitfic, Cat.#PA-13442). В качестве вторичных антител применяли
AlexaFluor®555 goat anti-rabbit IgG(H+L) (Molecular Probes, Cat#A21429), AlexaFluor®488 goat anti-mouse
IgG(H+L) (Molecular Probes, Cat#A11029), AlexaFluor®488 goat anti-guinea pig IgG(H+L) (Molecular Probes,
Cat#A11073).
РЕЗУЛЬТАТЫ: при использовании антител разных производителей выявлены существенные отличия
в распределении иммунореактивности к инсулину. В реакциях с антителами фирм Thermo Scientific, Santa
Cruz Biotechnology, Golden Bridge, Dako, инсулин+ β-клетки выявлены во всех островках ПЖ людей из груп-
пы сравнения, а также в немногочисленных (около 10% от общего количества) островках ПЖ у ребенка
и подростка с недавно диагностированным СД1. В большинстве островков ПЖ у ребенка и подростка
и во всех островках ПЖ в двух случаях продолжительного СД1 реакция на инсулин была иммунонегативной
(инсулин-дефицитные островки). Колокализация инсулина с глюкагоном обнаружена в единичных клетках
островков ПЖ в группе сравнения и в сохранившихся инсулин-содержащих островках ребенка и подростка
с СД1. При использовании антител фирм Sigma и Abcam наряду с иммунопозитивной реакцией на инсулин
в β-клетках инсулин-содержащих островков, реакция на инсулин меньшей интенсивности обнаружена
в большинстве глюкагон-содержащих клеток инсулин-дефицитных островков ПЖ людей с СД1. Сходная
иммунопозитивная реакция наблюдалась в большинстве глюкагон-содержащих клеток в островках ПЖ
людей из группы сравнения и сохранившихся островках ПЖ у ребенка и подростка с СД1.
ВЫВОДЫ: выявленные различия в распределении иммунореактивности к инсулину, вероятно, об-
условлены различной чувствительностью и эпитоп-специфичностью применяемых антител. Полученные
результаты свидетельствуют о том, что большинство глюкагон-позитивных клеток одновременно содержат
инсулин или его предшественники (проинсулин, препроинсулин) и могут служить источником эндогенного
инсулина даже у людей с продолжительным СД1.
ФИНАНСИРОВАНИЕ: работа выполнена в рамках государственного задания НИОКТР – 122030200535-1.
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Barbosa, Fábio C. "High Speed Intercity and Urban Passenger Transport Maglev Train Technology Review: A Technical and Operational Assessment". In 2019 Joint Rail Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/jrc2019-1227.
Abstract (sommario):
Magnetic levitation (maglev) is a highly advanced technology which provides, through magnetic forces, contactless movement with no wear and friction and, hence, improved efficiency, followed by reduced operational costs. It can be used in many fields, from wind turbines to nuclear energy and elevators, among others. Maglev trains, which use magnetic levitation, guidance and propulsion systems, with no wheels, axles and transmission, are one of the most important application of the maglev concept, and represents the first fundamental innovation of rail technology since the launch of the railroad era. Due to its functional features, which replaces mechanical components by a wear free concept, maglev is able to overcome some of the technical restrictions of steel-wheel on rail (SWR) technology, running smoother and somewhat quieter than wheeled systems, with the potential for higher speeds, acceleration & braking rates and unaffected by weather, which ultimately makes it attractive for both high speed intercity and low speed urban transport applications. From a technical perspective, maglev transport might rely on basically 3 technological concepts: i) electromanetic suspension (EMS), based on the attraction effect of electromagnets on the vehicle body, that are attracted to the iron reactive rails (with small gaps and an unstable process that requires a refined control system); ii) Electrodynamic Levitation (EDL), which levitates the train with repulsive forces generated from the induced currents, resulted from the temporal variation of a magnetic field in the conductive guide ways and iii) Superconducting Levitation (SML), based on the so called Meissner Effect of superconductor materials. Each of these technologies present distinct maturity and specific technical features, in terms of complexity, performance and costs, and the one that best fits will depend on the required operational features of a maglev system (mainly speed). A short distance maglev shuttle first operated commercially for 11 years (1984 to 1995) connecting Birmingham (UK) airport to the the city train station. Then, high-speed full size prototype maglev systems have been demonstrated in Japan (EDL) (552 kph - 343 mph), and Germany (EMS) (450 kph - 280 mph). In 2004, China has launched a commercial high speed service (based on the German EMS technology), connecting the Pudong International Airport to the outskirts of the city of Shanghai. Japan has launched a low speed (up to 100 kph - 62.5 mph) commercial urban EMS maglev service (LIMINO, in 2005), followed by Korea (Incheon, in 2016) and China (Changsha, in 2016). Moreover, Japan is working on the high speed Maglev concept, with the so called Chuo Shinkansen Project, to connect Tokio to Nagoya, in 2027, with top speeds of 500 kph (310 mph). China is also working on a high speed maglev concept (600 kph - 375 mph), supported on EMS Maglev technology. Urban Maglev concept seeks to link large cities, with their satellite towns and suburbs, to downtown areas, as a substitute for subways, due to its low cost potential, compared to metros and light rail (basically due to their lower turning radius, grade ability and energy efficiency). High Speed Maglev is also seen as a promising technology, with the potential do provide high quality passenger transport service between cities in the 240–1,000 km (150–625 mi) distance range into a sustainable and reliable way. This work is supposed to present, based on a compilation of a multitude of accredited and acknowledged technical sources, a review of the maglev transport technology, emphasizing its potential and risks of the low and high speed (urban and intercity) market, followed by a brief summary of some case studies.
Rapporti di organizzazioni sul tema "551.480 11":
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Pavlovic, Noel, Barbara Plampin, Gayle Tonkovich e David Hamilla. Special flora and vegetation of Indiana Dunes National Park. National Park Service, 2024. http://dx.doi.org/10.36967/2302417.
Abstract (sommario):
The Indiana Dunes (comprised of 15 geographic units (see Figure 1) which include Indiana Dunes National Park, Dunes State Park, and adjacent Shirley Heinze Land Trust properties) are remarkable in the Midwest and Great Lakes region for the vascular plant diversity, with an astounding 1,212 native plant species in an area of approximately 16,000 acres! This high plant diversity is the result of the interactions among postglacial migrations, the variety of soil substrates, moisture conditions, topography, successional gradients, ?re regimes, proximity to Lake Michigan, and light levels. This richness is all the more signi?cant given the past human alterations of the landscape resulting from logging; conversion to agriculture; construction of transportation corridors, industrial sites, and residential communities; ?re suppression; land abandonment; and exotic species invasions. Despite these impacts, multiple natural areas supporting native vegetation persist. Thus, each of the 15 units of the Indiana Dunes presents up to eight subunits varying in human disturbance and consequently in ?oristic richness. Of the most signi?cant units of the park in terms of number of native species, Cowles Dunes and the Dunes State Park stand out from all the other units, with 786 and 686 native species, respectively. The next highest ranked units for numbers of native species include Keiser (630), Furnessville (574), Miller Woods (551), and Hoosier Prairie (542). The unit with lowest plant richness is Heron Rookery (220), with increasing richness in progression from Calumet Prairie (320), Hobart Prairie Grove (368), to Pinhook Bog (380). Signi?cant natural areas, retaining native vegetation composition and structure, include Cowles Bog (Cowles Dunes Unit), Howes Prairie (Cowles Dunes), Dunes Nature Preserve (Dunes State Park), Dunes Prairie Nature Preserve (Dunes State Park), Pinhook Bog, Furnessville Woods (Furnessville), Miller Woods, Inland Marsh, and Mnoke Prairie (Bailly). Wilhelm (1990) recorded a total of 1,131 native plant species for the ?ora of the Indiana Dunes. This was similar to the 1,132 species recorded by the National Park Service (2014) for the Indiana Dunes. Based on the nomenclature of Swink and Wilhelm (1994), Indiana Dunes National Park has 1,206 native plant species. If we include native varieties and hybrids, the total increases to 1,244 taxa. Based on the nomenclature used for this report?the Flora of North America (FNA 2022), and the Integrated Taxonomic Information System (ITIS 2022)?Indiana Dunes National Park houses 1,206 native vascular plant species. As of this writing (2020), the Indiana Dunes is home to 37% of the species of conservation concern in Indiana (241 out of 624 Indiana-listed species): state extirpated = 10 species, state endangered = 75, and state threatened = 100. Thus, 4% of the state-listed species in the Indiana Dunes are extirpated, 31% endangered, and 41% threatened. Watch list and rare categories have been eliminated. Twenty-nine species once documented from the Indiana Dunes may be extirpated because they have not been seen since 2001. Eleven have not been seen since 1930 and 15 since 1978. If we exclude these species, then there would be a total of 1,183 species native to the Indiana Dunes. Many of these are cryptic in their life history or diminutive, and thus are di?cult to ?nd. Looking at the growth form of native plants, <1% (nine species) are clubmosses, 3% (37) are ferns, 8% (297) are grasses and sedges, 56% (682) are forbs or herbs, 1% (16) are herbaceous vines, <1% (7) are subshrubs (woody plants of herbaceous stature), 5% (60) are shrubs, 1% (11) are lianas (woody vines), and 8% (93) are trees. Of the 332 exotic species (species introduced from outside North America), 65% (219 species) are forbs such as garlic mustard (Alliaria petiolata), 15% (50 species) are graminoids such as phragmites (Phragmites australis ssp. australis), 2% (seven species) are vines such as ?eld bindweed (Convulvulus arvensis), <1% (two species) are subshrubs such as Japanese pachysandra (Pachysandra terminalis), 8% (28 species) are shrubs such as Asian bush honeysuckle (Lonicera spp.), 1% (three species) are lianas such as oriental bittersweet (Celastrus orbiculatus), and 8% (23 species) are trees such as tree of heaven (Ailanthus altissimus). Of the 85 adventive species, native species that have invaded from elsewhere in North America, 14% (11 species) are graminoids such as broom sedge (Andropogon virginicus), 57% (48 species) are forbs such as fall phlox (Phlox paniculata), 5% (six species) are shrubs such as Carolina allspice (Calycanthus floridus), 3% (two species) are subshrubs such as holly leaved barberry (Berberis repens), 1% (one species) is a liana (trumpet creeper (Campsis radicans), 3% two species) are herbaceous vines such as tall morning glory (Ipomoea purpurea), and 17% (15 species) are trees such as American holly (Ilex opaca). A total of 436 species were found to be ?special? based on political rankings (federal and state-listed threatened and endangered species), species with charismatic ?owers, and those that are locally rare.
2
Newman-Toker, David E., Susan M. Peterson, Shervin Badihian, Ahmed Hassoon, Najlla Nassery, Donna Parizadeh, Lisa M. Wilson et al. Diagnostic Errors in the Emergency Department: A Systematic Review. Agency for Healthcare Research and Quality (AHRQ), dicembre 2022. http://dx.doi.org/10.23970/ahrqepccer258.
Abstract (sommario):
Objectives. Diagnostic errors are a known patient safety concern across all clinical settings, including the emergency department (ED). We conducted a systematic review to determine the most frequent diseases and clinical presentations associated with diagnostic errors (and resulting harms) in the ED, measure error and harm frequency, as well as assess causal factors. Methods. We searched PubMed®, Cumulative Index to Nursing and Allied Health Literature (CINAHL®), and Embase® from January 2000 through September 2021. We included research studies and targeted grey literature reporting diagnostic errors or misdiagnosis-related harms in EDs in the United States or other developed countries with ED care deemed comparable by a technical expert panel. We applied standard definitions for diagnostic errors, misdiagnosis-related harms (adverse events), and serious harms (permanent disability or death). Preventability was determined by original study authors or differences in harms across groups. Two reviewers independently screened search results for eligibility; serially extracted data regarding common diseases, error/harm rates, and causes/risk factors; and independently assessed risk of bias of included studies. We synthesized results for each question and extrapolated U.S. estimates. We present 95 percent confidence intervals (CIs) or plausible range (PR) bounds, as appropriate. Results. We identified 19,127 citations and included 279 studies. The top 15 clinical conditions associated with serious misdiagnosis-related harms (accounting for 68% [95% CI 66 to 71] of serious harms) were (1) stroke, (2) myocardial infarction, (3) aortic aneurysm and dissection, (4) spinal cord compression and injury, (5) venous thromboembolism, (6/7 – tie) meningitis and encephalitis, (6/7 – tie) sepsis, (8) lung cancer, (9) traumatic brain injury and traumatic intracranial hemorrhage, (10) arterial thromboembolism, (11) spinal and intracranial abscess, (12) cardiac arrhythmia, (13) pneumonia, (14) gastrointestinal perforation and rupture, and (15) intestinal obstruction. Average disease-specific error rates ranged from 1.5 percent (myocardial infarction) to 56 percent (spinal abscess), with additional variation by clinical presentation (e.g., missed stroke average 17%, but 4% for weakness and 40% for dizziness/vertigo). There was also wide, superimposed variation by hospital (e.g., missed myocardial infarction 0% to 29% across hospitals within a single study). An estimated 5.7 percent (95% CI 4.4 to 7.1) of all ED visits had at least one diagnostic error. Estimated preventable adverse event rates were as follows: any harm severity (2.0%, 95% CI 1.0 to 3.6), any serious harms (0.3%, PR 0.1 to 0.7), and deaths (0.2%, PR 0.1 to 0.4). While most disease-specific error rates derived from mainly U.S.-based studies, overall error and harm rates were derived from three prospective studies conducted outside the United States (in Canada, Spain, and Switzerland, with combined n=1,758). If overall rates are generalizable to all U.S. ED visits (130 million, 95% CI 116 to 144), this would translate to 7.4 million (PR 5.1 to 10.2) ED diagnostic errors annually; 2.6 million (PR 1.1 to 5.2) diagnostic adverse events with preventable harms; and 371,000 (PR 142,000 to 909,000) serious misdiagnosis-related harms, including more than 100,000 permanent, high-severity disabilities and 250,000 deaths. Although errors were often multifactorial, 89 percent (95% CI 88 to 90) of diagnostic error malpractice claims involved failures of clinical decision-making or judgment, regardless of the underlying disease present. Key process failures were errors in diagnostic assessment, test ordering, and test interpretation. Most often these were attributed to inadequate knowledge, skills, or reasoning, particularly in “atypical” or otherwise subtle case presentations. Limitations included use of malpractice claims and incident reports for distribution of diseases leading to serious harms, reliance on a small number of non-U.S. studies for overall (disease-agnostic) diagnostic error and harm rates, and methodologic variability across studies in measuring disease-specific rates, determining preventability, and assessing causal factors. Conclusions. Although estimated ED error rates are low (and comparable to those found in other clinical settings), the number of patients potentially impacted is large. Not all diagnostic errors or harms are preventable, but wide variability in diagnostic error rates across diseases, symptoms, and hospitals suggests improvement is possible. With 130 million U.S. ED visits, estimated rates for diagnostic error (5.7%), misdiagnosis-related harms (2.0%), and serious misdiagnosis-related harms (0.3%) could translate to more than 7 million errors, 2.5 million harms, and 350,000 patients suffering potentially preventable permanent disability or death. Over two-thirds of serious harms are attributable to just 15 diseases and linked to cognitive errors, particularly in cases with “atypical” manifestations. Scalable solutions to enhance bedside diagnostic processes are needed, and these should target the most commonly misdiagnosed clinical presentations of key diseases causing serious harms. New studies should confirm overall rates are representative of current U.S.-based ED practice and focus on identified evidence gaps (errors among common diseases with lower-severity harms, pediatric ED errors and harms, dynamic systems factors such as overcrowding, and false positives). Policy changes to consider based on this review include: (1) standardizing measurement and research results reporting to maximize comparability of measures of diagnostic error and misdiagnosis-related harms; (2) creating a National Diagnostic Performance Dashboard to track performance; and (3) using multiple policy levers (e.g., research funding, public accountability, payment reforms) to facilitate the rapid development and deployment of solutions to address this critically important patient safety concern.