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Articoli di riviste sul tema "547.057 26":
1
Castro, Selma Barros Daltro de, José Wellington Marinho Aragão, Solange Mary Moreira Santos e Ivonete Barreto de Amorim. "O CONTEXTO DO CME EM FEIRA DE SANTANA: REVELANDO AS INTERSEÇÕES ENTRE O CENÁRIO NACIONAL E LOCAL". Interfaces Científicas - Educação 7, n. 3 (17 aprile 2019): 9–26. http://dx.doi.org/10.17564/2316-3828.2019v7n3p9-26.
Abstract (sommario):
A origem dos CME no Brasil tem relação direta com acontecimentos políticos e sociais de caráter mundial, nacional e local, o que exige considerar as relações existentes entre contexto nacional e local. O presente artigo problematizou a criação do Conselho Municipal de Educação, apresentando as relações existentes entre os contextos nacional e local. Para tanto, objetivou 1) contextualizar o surgimento do CME no contexto brasileiro, 2)analisar a criação do Conselho Municipal de Educação de Feira de Santana até o ano de 1996, apresentando as relações políticas estabelecidas no contexto nacional e local. A discussão teórica amparou-se em Ball e Mainardes ( 2011) Castro (2016). Saviani (1988, 2008, 2010), Souza ( 2006, 2013). A opção teórico-metodológica de pesquisa teve inspiração na abordagem do ciclo de políticas.Como estratégias metodológicas foram feitas a análise de documentos oficiais do município de Feira de Santana, a saber Leis Municipais n. 037/90, n.1 477/1991 e n.1 547/1992, Mensagem n. 011/96 do Executivo feirense encaminhada à Câmara de Vereadores, Atas da Câmara de Vereadores do ano de 1989; e a entrevista com um vereador de mandato no ano 1991. Os resultados revelam que o processo de criação do CME em Feira de Santana se iniciou com mobilização popular, encabeçada pelo movimento de professores da educação básica, enfatizando a necessidade de sistematização de espaços coletivos e democráticos na educação municipal, no final dos anos de 1980. Os textos oficiais elaborados no início da criação e organização do CME de Feira de Santana, Lei Municipais n. 037/90 n. 1.477/91 e 1.547/92 revelam tensões, debates, escuta do contraditório e culminam com a construção hibrida que ora revela a tendência de participação e democracia ora a tendência de centralizadora no âmbito da Educação. A descontinuidade administrativa, ocasionada pela forma de gerir e a priorização de outras ações dos novos gestores públicos, além da falta de mobilização docente para a continuidade dos debates acerca do CME e mudança de gestores em Feira de Santana foram aspectos que influenciaram a não continuidade das ações voltadas para a criação e implementação do CME em Feira de Santana até os anos de 1996.
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Zoughbie, Daniel E., Tin Lok James Ng, Jacqueline Y. Thompson, Kathleen T. Watson, Rami Farraj e Eric L. Ding. "Ramadan fasting and weight change trajectories: Time-varying association of weight during and after Ramadan in low-income and refugee populations". PLOS Global Public Health 2, n. 10 (26 ottobre 2022): e0000371. http://dx.doi.org/10.1371/journal.pgph.0000371.
Abstract (sommario):
Obesity is a significant driver of the global burden of non-communicable diseases. Fasting is one approach that has been shown to improve health outcomes. However, the effects of Ramadan fasting differ in that the type, frequency, quantity, and time of food consumption vary. This phenomenon requires in-depth evaluation considering that 90% of Muslims (~2 billion people) fast during Ramadan. To address this issue, we evaluated the pattern of weight change during and following Ramadan for a total of 52 weeks. The study was conducted in Amman, Jordan. Between 2012 and 2015, 913 participants were recruited as part of a trial investigating the efficacy of a weight loss intervention among those with or at risk for diabetes. Weight was measured weekly starting at the beginning of Ramadan, and changes were analyzed using discrete and spline models adjusted for age, sex, and trial group. Results show slight weight gain within the first two weeks and weight loss in the subsequent weeks. During the first week of Ramadan, the estimate for a weight reduction was 0·427 kg, (95% CI: -0·007, 0·861), increasing to 1·567 kg, (95% CI: 2·547, 3·527) at week 26. There was clear evidence of gradual weight gain from about 4 to 15 weeks and a drop towards the end of the investigation at week 28 (-0·12kg, 95% CI: -0·89, 0·56). Our results show that weight changes occurred during and after Ramadan. Weight fluctuations may affect health risks, and thus, findings from this study can inform interventions. Public health agencies could leverage this period of dietary change to sustain some of the benefits of fasting. The authors (DEZ, EFD) acknowledge the Mulago Foundation, the Horace W. Goldsmith Foundation, Robert Wood Johnson Foundation, and the World Diabetes Foundation. TRIAL REGISTRATION. Clinicaltrials.gov registry identifier: NCT01596244.
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Joshi, Y. N., e M. Mazzoni. "3d-Shell excitation in photoabsorption of atomic selenium". Canadian Journal of Physics 66, n. 4 (1 aprile 1988): 326–29. http://dx.doi.org/10.1139/p88-051.
Abstract (sommario):
The photoabsorption spectrum of the inner 3d-shell excitation of atomic selenium was observed in the 500–170 Å region using the flash-pyrolysis technique. The observations, aided by the Hartree–Fock ab initio calculations and least squares fitted parametric calculations, have lead to the classification of 15 lines in the 4p4–3d94s24p5 transition array and 26 lines in the 4p4–3d94s24p4np transitions. Two series ionization limits have been calculated as 517 500 cm−1 (64.15 eV) and 530 000 cm−1 (67.70 eV).
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Boadi, Dinah, e M. A. Price. "The effects of pre- and early post-calving management on reproductive performance of beef cows". Canadian Journal of Animal Science 76, n. 3 (1 settembre 1996): 337–42. http://dx.doi.org/10.4141/cjas96-050.
Abstract (sommario):
One hundred and thirty-four pregnant beef cows (liveweight = 544.3 kg ± 73 3 kg SD; condition score = 3.5 ± 0.3 SD), were randomly assigned in January to five management treatments (combinations of feed restriction and weaning time) to study the effects on calving and rebreeding performance. Twenty-seven were feed-restricted (54.7 MJ DE d−1) for the last 3 mo of pregnancy then realimented (3REST); their calves were weaned in October. Thirty were feed-restricted for the last 3 mo of pregnancy (54.7 MJ DE d−1) and the first 2 mo of lactation (99.6 MJ DE d−1), then their calves were weaned and turned out to graze in June (5REST). The remaining 77 cows (UNREST) were supplemented on range with 153.5 MJ DE d−1 from January until calving. Their calves were weaned in either August (one group of 26 calves directly into a feedlot, a second group of 26 onto unsupplemented range) or October (25 calves directly into a feedlot). All cows grazed together on the range from June onwards. After calving, the restricted (3REST and 5REST) cows were significantly lighter (464.4 and 469.5 kg vs. 506.9 kg) and thinner (condition scores 2.5 and 2.6 vs. 3.0) than the UNREST cows, but the percentage of cows calving calf mortality, assisted births calving dates, udder scores and mean birth weight of calves were not affected (P > 0.05) by pre-calving nutrition. Catch-up growth was evident in both the 3REST and 5REST cows once exposed to higher energy feeding. There were no significant effects (P > 0.05) of the management (nutrition and weaning) treatments on the following year s breeding and calving performance. It is concluded that the combinations of nutrition and weaning used in this study did not necessarily impair calving or rebreeding performance of beef cows, which calved in condition score 2.5 or above. Key words: Beef cows, feed restriction, reproduction, condition score, rebreeding, birthweight
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CUTCLIFFE, J. A. "EFFECTS OF LIME AND GYPSUM ON YIELDS AND NUTRITION OF TWO CULTIVARS OF BRUSSELS SPROUTS". Canadian Journal of Soil Science 68, n. 3 (1 agosto 1988): 611–15. http://dx.doi.org/10.4141/cjss88-059.
Abstract (sommario):
Field experiments were carried out at different locations in Prince Edward Island each year for 3 consecutive years to determine the effects of calcific limestone, dolomitic limestone, and gypsum on yields and nutrition of two cultivars of Brussels sprouts (Brassica oleracea var. gemmifera). The soils at the sites selected had initial pH levels of 4.9–5.7. Preplant, broadcast applications of gypsum at 5.5 t ha−1 resulted in yield increases of about 30% at all locations. Analysis of leaf tissue collected when the sprouts began to form indicated that Ca, Mg, Mn and Zn concentrations of approximately 1.4–2.6%, 0.25–0.32%, 88–274 μg g−1 and 26–35 μg g−1, respectively, are within the sufficiency range. The incidence of internal browning was not affected by either the lime or gypsum treatments at the two locations where this disorder occurred. Key words: Lime, gypsum, yield, leaf tissue nutrient concentration, internal browning, Brussels sprouts
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Vladimirov, Vladimir, Antonina Mostyakova, Leonid Egorov e Filus Agiev. "POTATO PRODUCTIVITY DEPENDING ON THE METHOD OF APPLICATION OF GROWTH REGULATOR AND CALCULATED BACKGROUND OF MINERAL NUTRITION ON THE GRAY FOREST STEPPE SOIL OF MIDDLE VOLGA REGION". Vestnik of Kazan State Agrarian University 14, n. 4 (5 febbraio 2020): 21–26. http://dx.doi.org/10.12737/2073-0462-2020-21-26.
Abstract (sommario):
The reaction of the early ripening potato of Vineta variety to different methods of using growth regulators against the calculated background of mineral nutrition on the gray forest-steppe soil of middle Volga was studied. The effectiveness of processing planting tubers and foliar treatment of plants during their vegetation has been established. The experiments were carried out on the control without the introduction of NPK and on a fertilized background, designed to obtain a tuber crop of 40 tons per hectare. The studies were conducted on gray forest medium loam granulometric composition soil of “Zemlyaki” farm in Nizhnekamsk district of the Republic of Tatarstan. Field experiments were carried out in 2019 by employees of Plant Growing and Horticulture Department of Kazan State Agrarian University. The humus content in the arable layer of soil according to Tyurin is 3.35%, pH is 5.7, easily hydrolyzable nitrogen is 112 mg/kg of soil, mobile phosphorus is 156 mg/kg, exchange potassium is 136 mg/kg of soil, molybdenum is 0.07, copper is 0.52, boron - 0.7, zinc - 4.82 mg/kg. The effectiveness of the integrated use of growth regulators (treatment of planting tubers and foliar application of the drug during the growing season) has been established. The yield increase to control against the background without applying basic fertilizers amounted to 4.82 tons per hectare, and against the background of their application - 4.80 tons per hectare.
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Christian Louis, Kouakou Ehaulier Soh, Same Bebey Francine, Sougué Charles, Seri Serge Landry, Yao Konan Joe Clauvis, Traore Aissata, Koffi Joseph Kan Enock, Goua Jean Jacques, Goupille Phillipe e Daboiko Jean Claude Felix. "Apport de la Rééducation dans la Prise en Charge de la Lombalgie/Lomboradiculalgie Commune Chronique à Abidjan : Amélioration de la Douleur et de la Capacité Fonctionnelle dans 95% des Cas". European Scientific Journal, ESJ 19, n. 27 (30 settembre 2023): 97. http://dx.doi.org/10.19044/esj.2023.v19n27p97.
Abstract (sommario):
Objectif : Evaluer l’apport de la rééducation dans la prise en charge de la lombalgie/lomboradiculalgie commune chronique (LRCC). Patients et méthodes : Il s’est agi d’une étude prospective transversale allant du 1er janvier 2015 au 1er mai 2016 (16 mois), portant sur des cas de LRCC vu en rééducation au CHU de Cocody à Abidjan en Côte d’ivoire. L’échelle Eifel a permis d’évaluer la capacité fonctionnelle des patients. Il s’agissait de comparer l’intensité de la douleur et de son retentissement fonctionnel avant et après rééducation. Résultats : Sur 1380 patients vus, 86 souffraient de LRCC (6,23 %) soit 46 cas de lombalgie isolée (53,5%) et 40 cas de lomboradiculalgie (46,5%). Leur âge moyen était de 49,9 ans +/- 11,7 (extrêmes : 14 et 71 ans) et le sex ratio de 0,43 (26 hommes et 60 femmes). Le nombre moyen de séances de rééducation effectué était de 13,5±5,2 (Extrêmes : 5 et 25) avec une durée moyenne de 1,6 mois ±0,7 (Extrêmes : 1 et 5). L’évolution clinique était favorable chez 82 patients (95,35%). L’échelle visuelle analogique (EVA) moyenne était de 6,3±2 avant la rééducation, et de 1,8±1,6 après rééducation. Le score moyen de l’échelle EIFEL était de 13,38±5,7 avant la rééducation et de 3,6±4,82 après rééducation. Il existait une amélioration statistiquement significative de l’intensité de la douleur (p=0,02), et de la capacité fonctionnelle des patients après la rééducation (p=0,03). Conclusion : Les patients souffrant de LRCC consultent dans un contexte hyperalgique et invalidant en rééducation au CHU de Cocody. Les séances de rééducation permettent une amélioration de la douleur et de la capacité fonctionnelle des patients.
Objective: To evaluate the contribution of rehabilitation in the management of chronic low back pain/ lomboradiculalgia (LRCC). Patients and methods: This was a 16-month prospective cross-sectional study from January 1, 2015, to May 1, 2016, of LRCC cases seen in rehabilitation at the University Hospital of Cocody in Abidjan, Ivoiry Coast. The Eifel scale was used to assess the functional capacity of patients. The aim was to compare the intensity of pain and its functional impact before and after rehabilitation. Results: Of 1380 patients seen, 86 had LRCC (6.23%), i.e. 46 cases of isolated low back pain (53.5%) and 40 cases of lumbaradiculalgia (46.5%). Their mean age was 49.9 years +/- 11.7 (extremes: 14 and 71 years) and the sex ratio was 0.43 (26 men and 60 women). The average number of rehabilitation sessions performed was 13.5±5.2 (extremes: 5 and 25) with an average duration of 1.6 months ±0.7 (extremes: 1 and 5). The clinical evolution was favorable in 82 patients (95.35%). The mean visual analog scale (VAS) was 6.3±2 before rehabilitation, and 1.8±1.6 after rehabilitation. The mean EIFEL score was 13.38±5.7 before rehabilitation and 3.6±4.82 after rehabilitation. There was a statistically significant decrease in pain intensity (p=0.02), and a statistically significant improvement in patients' functional capacity after rehabilitation (p=0.03). Conclusion: Patients suffering from LRCC consult in a hyperalgesic and disabling context in rehabilitation at Cocody. The rehabilitation sessions allow an improvement of the pain and the functional capacity of the patients.
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Brinkworth, Grant D., Thomas P. Wycherley, Pennie J. Taylor e Campbell H. Thompson. "A Health Care Professional Delivered Low Carbohydrate Diet Program Reduces Body Weight, Haemoglobin A1c, Diabetes Medication Use and Cardiovascular Risk Markers—A Single-Arm Intervention Analysis". Nutrients 14, n. 20 (20 ottobre 2022): 4406. http://dx.doi.org/10.3390/nu14204406.
Abstract (sommario):
This study examined the effectiveness of a health care professional delivered low-carbohydrate diet program (Diversa Health Program) aiming to improve obesity/type-2-diabetes management for people living in Australia. 511 adults (Age:57.1 ± 13.7 [SD] yrs) who participated between January 2017–August 2021 for ≥30 days with pre-post data collected for ≥1 key outcome variable (body weight and HbA1c) were included in the analysis. Average participation duration was 218 ± 207 days with 5.4 ± 3.9 reported consultation visits. Body weight reduced from 92.3 ± 23.0 to 86.3 ± 21.1 kg (n = 506, p < 0.001). Weight loss was −0.9 ± 2.8 kg (−1.3%), −4.5 ± 4.3 kg (−5.7%) and −7.9 ± 7.2 kg (7.5%), respectively, for those with a classification of normal weight (n = 67), overweight (n = 122) and obese (n = 307) at commencement. HbA1c reduced from 6.0 ± 1.2 to 5.6 ± 0.7% (n = 212, p < 0.001). For members with a commencing HbA1c of <5.7% (n = 110), 5.7–6.4% (n = 55), and ≥6.5% (n = 48), HbA1c reduced −0.1 ± 0.2%, −0.3 ± 0.3%, and −1.4 ± 1.3%, respectively. For members with a commencing HbA1c ≥6.5%, 90% experienced a HbA1c reduction and 54% achieved a final HbA1c < 6.5. With inclusion and exclusion of metformin, respectively, 124 and 82 diabetes medications were prescribed to 63 and 42 members that reduced to 82 and 35 medications prescribed to 51 and 26 members at final visit. A health care professional delivered low-carbohydrate diet program can facilitate weight loss and improve glycaemic control with greatest improvements and clinical relevance in individuals with worse baseline parameters.
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Laseter, Isaac H., Steven L. Finkelstein, Micaela J. Bagley, Dustin M. Davis, Karl Gebhardt, Caryl Gronwall, Robin Ciardullo, Gregory R. Zeimann, Erin Mentuch Cooper e Daniel Farrow. "A Search for Lensed Lyα Emitters within the Early HETDEX Data Set". Astrophysical Journal 940, n. 1 (1 novembre 2022): 9. http://dx.doi.org/10.3847/1538-4357/ac9186.
Abstract (sommario):
Abstract The Hobby–Eberly Telescope Dark Energy Experiment (HETDEX) is a large-volume spectroscopic survey without preselection of sources, searching ∼540 deg2 for Lyα emitting galaxies (LAEs) at 1.9 < z < 3.5. Taking advantage of such a wide-volume survey, we perform a pilot study using early HETDEX data to search for lensed Lyα emitters (LAEs). After performing a proof of concept using a previously known lensed LAE covered by HETDEX, we perform a search for previously unknown lensed LAEs in the HETDEX spectroscopic sample. We present a catalog of 26 potential LAEs lensed by foreground, red, non-star-forming galaxies at z ∼ 0.4–0.7. We estimate the magnification for each candidate system, finding 12 candidates to be within the strong lensing regime (magnification μ > 2). Follow-up observations of these potential lensed LAEs have the potential to confirm their lensed nature and explore these distant galaxies in more detail.
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Mukherjee, Akash, Denai R. Milton, Elias Jabbour, Marina Konopleva, Courtney Denton Dinardo, Alison Gulbis, Farhad Ravandi et al. "Allogeneic stem cell transplantation (AlloSCT) for patients (pts) with acute leukemia following venetoclax-based therapy." Journal of Clinical Oncology 37, n. 15_suppl (20 maggio 2019): 7047. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.7047.
Abstract (sommario):
7047 Background: BCL-2 inhibitor Ven has shown a promising benefit in pts with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). There is paucity of information about the safety and efficacy of alloSCT post Ven. Methods: We conducted a retrospective analysis of 35 AML/ALL pts who received alloSCT following Ven-based therapies between 2013-2018 at MDA. Results: Median age at alloSCT was 60 years and 15 (43%) pts had an age-adjusted HCT-CI score ≥ 4. Disease diagnosis – AML (n = 31; 89%), ALL (n = 4; 11%). Disease status at transplant was CR1 (n = 17; 49%), CR2/CR3 (n = 9; 26%) or refractory (n = 9; 26%). 20/26 (77%) CR pts were MRD-negative. Median # of prior therapies was 2 (range 1-7) and 4 (11%) pts had failed a prior alloSCT. AML pts were classified by ELN 2017 criteria to have favorable, intermediate and adverse risks in 16%, 23% and 61% respectively. Ven was provided in combination of hypomethylating agents (HMA) or other chemotherapies in 26 (74%) and 9 (26%) pts, respectively. Among pts treated with Ven + HMA, some also received IDH1/2 inhibitors (n = 7, 20%), FLT3 inhibitors (n = 4; 11%) or anti-PD1 (n = 3, 9%). Median duration of Ven-based treatment was 2 months (range 0.5- 4.6). Ven was discontinued in 6 (17%) pts due to adverse events (n = 4) or progression (n = 2); the remaining pts (83%) continued their Ven-therapy as a bridge to alloSCT. The median time from last Ven dose and transplant was 26 days. Conditioning regimens were melphalan-based reduced intensity (n = 26, 74%), or busulfan-based myeloablative regimens (n = 9; 26%). Donor source was matched -unrelated (n = 14, 40%), -related (n = 9; 26%) or haplo- (n = 12; 34%). GVHD prophylaxis consisted of tacrolimus with either PT-Cy in 25 (71%) pts or methotrexate in 10 (29%) pts. All pts engrafted (median day 30 donor cells = 100%). Median days to ANC > 500 and platelets > 20K was 15.5 and 22.5, respectively. With a median follow up of 5.7 months (range 0.7-15.4), the 1-year rates of OS, PFS, and NRM were 71%, 63% and 3% respectively. CI of acute grade 2-4 and 3-4 GVHD were 26% and 3% respectively. Four pts died: 3 because of disease relapse and 1 of infection. Conclusions: AlloSCT is a safe and feasible consolidation treatment option in acute leukemia pts who were pre- treated with Ven, without excessive risk of NRM or acute GVHD. Larger prospective studies are required to validate our observations.
Capitoli di libri sul tema "547.057 26":
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Aguiar, Rômulo Carlos de. "Anthrophophysiological analysis in a patient with Progressive Ossificant Fibrodysplasia: Casuistic". In UNITING KNOWLEDGE INTEGRATED SCIENTIFIC RESEARCH FOR GLOBAL DEVELOPMENT. Seven Editora, 2023. http://dx.doi.org/10.56238/uniknowindevolp-032.
Abstract (sommario):
The objective was to measure anthropophysiological variables in patients with FOP, comparing them to standards. For this, ECG / ECC, tomography, pulmonary functions, manovacuometry, bioimpedance, blood analysis and goniometry were performed. The resultsAA = 27 mm; LA = 26 mm; LV = 41 mm; RV = 30 mm; FSD-LV = 20 mm; septum = 5 mm; LV-BWLV = 5 mm; LA/AA = 0.96, FE = 83%; septum/BWLV = 1.00, FDV = 74 ml; SV = 61 ml; volume/mass = 1.03 ml / g; Normalized GSF-LV; under bronchodilator, FVC, FEV1 and PEF = 54%, 64% and 81% of the predictors; FEV1% and 2575 = 118% and 116% of the predictors; MEP = 65 mmH (↓42.7%) and MIP = 55 mmHg (↓63.2%); BM = 39.0 kg; h = 1.57 m; BMI = 15.8 k/m2; AC = 64 cm; % FM = 26%; MM = 27.39 kg; BMC = 1.53 kg; FLM = 28.92 kg; RIMM = 4.5 kg / m2; OI = 63.50%; normal blood glucose, triglycerides and CRP; RS, LS, LH, RA and LA = 0º, LK = 25º, RK = 40º, LE = 55º, RH = 110º, RE = 150º. The cardiovascular differences did not cause any dysfunction. FOP caused moderate restrictive respiratory disorder, Pimax / Pmax below the predictors, MC, h, BMI, CA, bone mineral content, low MLG and IO, immobility in 05 joints and impairment in 03, with 02 preserved. It was concluded that FOP is significantly compromising the respiratory system, with moderate restrictive respiratory disorder caused by the sharp convexity thoracic scoliosis directed to the left, due to the compromised position of bipedation due to the new calcifications, in addition to compromised movement and walking.
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"3. A Complementary Pair: Stylistic Experimentation in Mozart’s Final Piano Concertos, No. 26 in D, K. 537 (the ‘Coronation’), and No. 27 in Bb, K. 595". In Mozart's Viennese Instrumental Music, 64–88. Boydell and Brewer, 2007. http://dx.doi.org/10.1515/9781846155765-007.
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Santos, Dainara Silva dos, Eduarda Cavalcante dos Santos, Emilly Carollayne Leandro da Silva, Gabriela Maria Farias da Silva, Layane Karollyane da Silva, Hingridy Medereiros de Asevêdo Lúcio, Renata de Albuquerque Torres, Millena Bezerra Alves das Chagas, Maria Tarcyla Silva Xavier e Jakson Henrique Silva. "Predictive indices of ventilatory weanning in prematures: Literature review". In Navigating through the knowledge of education. Seven Editora, 2024. http://dx.doi.org/10.56238/sevened2024.002-037.
Abstract (sommario):
Objective: To describe the predictive indices for MV weaning in preterm infants. Methodology: This is a descriptive literature review, carried out in a bibliographic survey from July to September 2023, in articles published in the last 10 years, using the databases: National Library of Medicine (Pubmed), Scientific Electronic Library Online (SCIELO), Physiotherapy Evidence Databases (PEDro). RESULTS: Only three articles were selected for this review, showing that 56.5% of the newborns admitted to the NICU were male, with a mean GA of 25 to 36 weeks, birth weight of 754g to 1500g. Conclusion: The correct timing of weaning from mechanical ventilation and extubation is still considered a challenge in NICUs, where the scarcity of literature shows that further studies should be carried out in order to establish the best strategy for a possible success of extubation. Results: Gestational age ranges from 26 to 36 weeks and 6 days, birth weight from 882 g to 1500 g, APGAR score at 1' from 4.9 to 5.4 and at 5' from 6 to 8. In the clinical trials, the underlying diseases found were: In the first group, Respiratory Distress Syndrome (60.4-67.4%), preterm infants used Mechanical Ventilation from 27-29 hours, the number of deaths was 22 (50-53), and the following predictive indices were used: Evaluate: Pulmonary mechanics; Pressure-time index; Minute ventilation test; Clinical trials; and Dynamics of biological signals. In the randomized clinical trial. In group 2: Bronchopulmonary Dysplasia (30%); Intracranial hypertension (7.5%). Deaths in this group were 5.7% and the predictive indices used were: Higher APGAR score at 5 minutes; Higher pH (before extubation); Lowest peak FiO2 (in the first 24 hours of age); Lower PCO2 and FiO2 (before extubation); and Non-PIG status. Subgroup 2: Bronchopulmonary Dysplasia (64%); Intracranial hypertension (23%). Deaths in this group were 28% and the predictive index used was gestational age. And in the third study: Apnea 54.5%; SDR 18.1%; PCA: 5.5%. Days of mechanical ventilation was 2 days. The predictive indices used were: RR = 12 bpm; PIP = 16 cmH 2 0; PEEP = 6 cmH 2 0; FiO 2 ≤ 40%. In group 2 of the third study: Apnea: 16.6%; SDR 33.3%; PCA: 19.4%. Days of ventilation was 1 day and a half. The predictive indices used were: Pressure equal to .6 cmH 2 0; Oxygen Fraction from 2 ≤ 40%.
Atti di convegni sul tema "547.057 26":
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Apte, A., S. Chandrasekharan e E. Klenova. "Abstract P6-05-26: BORIS: A potential novel breast cancer biomarker". In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p6-05-26.
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Lannin, DR, BK Killelea, BJ Grube, N. Horowitz e AB Chagpar. "P3-07-26: How Generalizable Is the Patient Population Enrolled in ACOSOG Z11?" In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p3-07-26.
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Suzart, Gabriel Souza, Ingrid Sanchez, Daniel Guimarães, Pedro Augusto Assis Lopes e Pedro Antonio Pereira de Jesus. "Association between Human Development Index and Delay on Arrival to Stroke Unit". In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.668.
Abstract (sommario):
Background: Stroke outcomes depend somehow on the time taken from the symptoms onset until arrival to the specialized service. However, as it lacks literature exploring the impact of socio-demographics factors on this time, we investigated the association between Human Development Index and delay on arrival to specialized service. Design and setting: Cross-sectional study from a prospective cohort (PMID=33719516) at Hospital Geral Roberto Santos. Methods: From a total of 454 stroke patients, 156 were included in this study because they had registered address, time of admission and of symptoms onset. Patients had HDI defined by their address and were grouped into HDI categories. Results: In our sample, 57 (36,5%) individuals had medium HDI, 70 (44,9%) high HDI and 29 (18,6%) very high HDI. Very high HDI patients’ delay (2:01; 1:22-2:57) was lower than high HDI (3:05; 2:05-5:26) and medium HDI (2:25;1:45-4:04) patients. There was statistical significance comparing these groups (X²=11,41;p<0,05), but a post-hoc test revealed statistical difference just between the very high HDI and high HDI groups (p<0.05). Conclusions: We expected to find a direct relation between delay on arrival to the stroke service and HDI categories. However, this was not observed. *Authors contributed equally.
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von Minckwitz, G., K. Schwedler, M. Schmidt, J. Barinoff, C. Mundhenke, T. Cufer, E. Maartense et al. "Abstract P6-14-05: Final Overall Survival Analysis of the TBP Phase III Study (GBG 26/BIG 3-05): Capecitabine vs. Capecitabine + Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing during Trastuzumab Treatment". In Abstracts: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/0008-5472.sabcs10-p6-14-05.
5
"PV-058 - SUSTANCIAS DE CONSUMO DETECTADAS EN PACIENTES DUALES QUE INGRESAN EN LA UNIDAD DE AGUDOS DE PSIQUIATRÍA DEL HOSPITAL DE MATARÓ". In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.pv058.
Abstract (sommario):
Objetivos Describir sustancias de consumo en pacientes duales que ingresan en la Unidad de agudos de psiquiatría del H. de Mataró entre octubre- diciembre 2021. Material-métodos Pacientes ingresados tipo dual se analizan las sustancias de consumo principal y secundarias. Resultados- conclusiones Del total de 195 ingresos en unidad de agudos, un 27.1% (n=52) eran de perfil dual, el 61.5% de los pacientes hombres (n=32) y con edad media 50.5 años. La sustancia principal más frecuente cánnabis 34.6% (n=18), cocaína 21.2% (n=11) y alcohol 19.2% (n=10); anfetaminas 13.5% (n=7), hipnosedantes 7.6% (n=4) y óxido nitroso 2% (n=1). Consumos comórbidos: nicotina 65.38% (n=34), alcohol 53.8% (n=28); cánnabis 30.7% (n=16); cocaína 23.1% (n=12); hipnosedantes 15.3% (n=8); anfetaminas 9.6% (n=5), xantinas 9.6%. Metanfetamina 3.8% (n=2), opiáceos 5.7% (n=3), y 2% (n=1-respectivamente): GHB, estramonio, ketamina, Popper. Cánnabis: alguna vez 83% (n=43), habitual 70% (n = 26), marihuana 53% (n=18), hachís 43% (n=15) y CBD 3% (n=1). Consumo medio 0.75-1g/día. Cocaína: alguna vez 75% (n=39), habitual 29% (n= 9). El 93% inició esnifada (n=28) y 7% (n=2) inhalada; actualmente esnifado 70% (n=14), inhalado 20% (n=4), fumado 5% (n=1) e inyectado 5%. Consumo medio 0.8g/d. Anfetaminas: ocasional 33% (n=17), habitual 58% (n=7), vía esnifada. Hipnosedantes: 33% (n=17) habían consumido, de los cuales habitualmente 75% (n=9): Diazepam 29.4% (n = 5); Clonazepam 29.4% (n=5), Lorazepam 23.5% (n=4) y Alprazolam 17.6% (n=3), Midazolam 11.7% (n=2); y Lormetazepam 5.8% (n=1). Dosis media 53mg/d equivalentes-Diazepam. Opiáceos: heroína alguna vez 13% (n= 7), ninguno habitual; opiáceos no-heroína 4% (n=2). Tabaco: 79% (n= 41), habitual 80.5% (n=33), tipo procesado 75.7% (n=25) y de liar el 24.2% (n=8). Media de 20 unidades/día. Se registró ChemSex 2% (n=1). Conclusiones: Resultados de acuerdo a fuentes principales: Informe-Europeo-Drogas 2021 y ESTUDES-2021-OEDA: incrementa cánnabis en adulto-joven, mantenimiento de tabaco y alcohol, descenso psicoestimulantes y retroceso opiáceos.
6
Kadoya, T., E. Akimoto, A. Emi, H. Shigematsu, N. Masumoto e M. Okada. "Abstract P6-07-26: Prognostic significance of the maximal value of the baseline standardized uptake value on fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography for predicting pathologic malignancy of operable breast cancer with neoadjuvant chemotherapy". In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p6-07-26.
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Сокуева, Х. Ю. "КОМОРБИДНОСТЬ ПАЦИЕНТОВ С ОСТРЫМ ПЕРЕДНИМ Q ИНФАРКТОМ МИОКАРДА И САХАРНЫМ ДИАБЕТОМ 2 ТИПА". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-91.
Abstract (sommario):
ЦЕЛЬ: изучить коморбидность больных с сахарным диабетом 2 типа (СД2), получающих лечение по по-
воду переднего острого инфаркта миокарда (ОИМ) с зубцом Q.
МАТЕРИАЛЫ И МЕТОДЫ: в исследование вошли 90 пациентов с передним ОИМ с зубцом Q, получаю-
щие гликлазид (n=30, 1-группа), глимепирид (n=30, 2 группа) и глибенкламид (n=30, 3 группа). Изучались
липидограмма, гликированный гемоглобин (HbA1C), креатинин, альбуминурия, осматривались неврологом,
окулистом, рассчитывался индекс массы тела (ИМТ).
РЕЗУЛЬТАТЫ: мужчин было 43 (47,7%), а женщин 47 (52,3%). Возраст мужчин составлял 60±9 [57-62] лет,
женщин 53±8 [50-55]. В 1 группе ИМТ составил 30,4±2,1[29,6-31,1] кг/м2, во 2 группе ИМТ 31,6±2,3 [30,7-32,4],
а в 3 группе- 31,2±3,9 [29,8-32,6] кг/м2. При проведении анализа корреляционной взаимосвязи ИМТ от стажа
СД2 была установлена высокой тесноты обратная связь (р<0,001, rxy= -0,782). При увеличении стажа СД2
на 1год следует ожидать уменьшение ИМТ на 0,402. Полученная модель объясняет 61,2% наблюдаемой
дисперсии. При оценке связи ИМТ и возраста была установлена умеренной тесноты обратная связь. При
увеличении возраста на 1 следует ожидать уменьшение показателя ИМТ на 0,319. При оценке связи ИМТ
и дозы препарата сульфонилмочевины (ПСМ) связь отсутствовала. При увеличении дозы ПСМ на 1 следует
ожидать увеличение ИМТ на 0,019. У всех пациентов регистрировалась дислипидемия: ЛПНП в 1 груп-
пе 3,2±0,4[3,06-3,34], во 2 группе 3,2±0,6 [2,99 -3,41], в 3 группе 3,3±0,7 [3,05-3,55]; холестерин в 1 группе
5,7±1,0 [5,34-6,06], в 2 группе 5,9±0,9 [5,58-6,22], в 3 группе 6,1±0,9 [5,7-6,42]. У всех больных была выявлена
артериальная гипертензия (АГ). Во всех группах диагностировались хроническая болезнь почек (ХБП).
В 1 группе было с ХБП С2А1 5 пациентов (16,7%), 17 больных с ХБП С3а (А1-А2) (56,7%) и 8- ХБП С3б (А1-А2)
(26,7%). Во 2 группе ХБП С2А1 3,3% (n=1), ХБП С3а (А1-А2) 86,7% (n=26), ХБП С3б (А1-А2) 10% (n=3). В 3 группе
ХБПС2А1 40%(n=12), ХБП С3аА1-А2 36,7%(n=11), ХБП С3бА1-А2 23,3% (n=7). Из 90 пациентов со скоростью
клубочковой фильтрации (СКФ) более 50мл/мин/1.73 м2 было 14, а с менее 50 мл/мин/1.73 м2-16 больных.
Чем больше стаж СД2, тем меньше СКФ был. Был проведен анализ для выявления связи между СКФ и дли-
тельности СД2. Исходя из полученных данных при сопоставлении показателя стажа СД более 6 лет и по-
казателя СКФ менее 50 мл/мин/1.73 м2, были установлены статистически значимые различия (p = 0,004,
p < 0,001). Анализ показал, шанс иметь СКФ меньше 50 при наличии СД2 более 6 лет были выше в 37,500 раз,
по сравнению с СД менее 6 лет, различия шансов были статистически значимыми (95% ДИ: 3,638 – 386,513).
HbA1C составил 9,3±1,2 [9,1-9,6]. Корреляционный анализ показал, что при увеличении стажа СД2 на 0,446
следует ожидать увеличение HbA1C на 1. При увеличении HbA1C на 1 следует ожидать увеличение СКФ
на 1,007. При увеличении HbA1C на 1 следует ожидать уменьшение ИМТ на 0,518. При осмотре глазного
дна выявились в 1 группе 80% (n=24) больных с ретинопатией, во 2 группе 80 % (n=24), в 3 группе 66,6 %
(n=20). Всем больным был выставлен диагноз диабетическая полинейропатия.
ВЫВОДЫ: больные с СД2 и передним ОИМ с зубцом Q имели осложнения и заболевания, которые
говорили о наличии и риске значимых сердечно-сосудистых осложнений.
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Contreras, Alejandra, Bonnie Leadbeater e Sybil Goulet-Stock. "The effects tailored interventions on cannabis use motives". In 2021 Virtual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2022. http://dx.doi.org/10.26828/cannabis.2022.01.000.01.
Abstract (sommario):
Background: The motives for cannabis affect on cannabis use and cannabis use consequences. Coping with stress is among the frequent motives for cannabis use. However, non stressed youth may use cannabis for self-enhancing motives like boosting confidence. Both motives are associated with higher frequency of cannabis use and more negative consequences (e.g., effects on schoolwork quality). Interventions targeting these distinctive motives may need to be tailored to assist youth trying to reduce cannabis use. The purposes of this study were: to examine the effect of cannabis use interventions on the change in motives of use; and whether motives for use are associated with hours per week using cannabis. Methods: Participants were from a cross national study including US and Canadian youth (n= 781). Participants included in the current analysis were from two Canadian Universities (n = 397, 54% female, median age = 21) were randomized into either the Cannabis eCHECKUP TO GO or Healthy Stress Management (HSM) intervention. Both interventions were administrated online and assessed at baseline and at a 4- to 6-week follow-up. Eligible youth reported using cannabis more than once a week and wanted to reduce their cannabis use. The 19 items to the question “what do you like about cannabis” were used as an assessment of motives for use (e.g., I feel more courageous, I feel more confident, cannabis helps me reduce stress, cannabis helps me sleep). Confirmatory Factor Analysis showed that a 2-factor model of cannabis use motives (self-confidence and stress-coping) fit the data adequately (CFI = 0.795, RMSEA [90% CI] = .063 [.057, .069]) after removing 2 poorly fitting items. Results: Across conditions self-confidence motives (T1: eCHECKUP condition M = 4.05(2.55), HSM condition M = 4.13(2.43); T2: eCHECKUP condition M = 4.09(2.50), HSM condition M = 4.36(2.28)) were endorse less than stress-coping motives (T1: eCHECKUP condition M = 6.48(1.92), HSM condition M = 6.25(1.78); T2: eCHECKUP condition M = 6.20(1.99), HSM condition M = 6.32(1.96)). Stress-coping motives were significantly correlated with the time spent high (hours a week) (T1 r= .21, T2: r=.26). A repeated measures MANOVA showed a significant interaction between time and intervention condition for the stress-coping motives only (F(1)= 4.08, p = .04). Participants in the Healthy Stress Management condition reported a significant decrease in the amount of stress-coping motives at the follow-up. Conclusions: These results demonstrate that motives of cannabis use can change over the course of a short online intervention for students seeking to reduce their use. In particular, the Healthy Stress Management condition helped participants reduce their stress-coping motives at T2. Neither intervention affected self confidence motives in the short term. These may be harder to address and may fuel continued use over time, even for youth hoping to change.
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Souza, Denis Carvalho de, e Myuki Alfaia Esashika Crispin. "PERFIL EPIDEMIOLÓGICO DOS DOADORES DE SANGUE DA FUNDAÇÃO HEMOAM INFECTADOS PELO VÍRUS DA IMUNODEFICIÊNCIA HUMANA, NO PERÍODO DE 2017 A 2019". In II Congresso Brasileiro de Hematologia Clínico-laboratorial On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/hematoclil/163.
Abstract (sommario):
Introdução: Na última década, a epidemia de HIV/aids no norte do Brasil, em especial no estado do Amazonas é crescente, e caracteriza-se por um aumento acentuado dos casos de incidência do HIV/aids. Doadores de sangue infectados pelo HIV são considerados uma importante população sentinela para a vigilância epidemiológica, no entanto, dados sobre a epidemiologia dessa infecção em doadores de sangue ainda são escassos. Objetivo: Identificar o perfil epidemiológico dos doadores de sangue e a prevalência de coinfecção do HIV/vírus das hepatites B, HIV/vírus da Hepatite C, HIV/vírus linfotrópico das células T humanas HTLV-1/2, HIV/Sífilis e HIV/Doença de Chagas da Fundação HEMOAM no período de 2017 a 2019. Metodologia: Trata-se de um estudo transversal e retrospectivo. Na triagem dos doadores de sangue para o HIV foi utilizado o método de Quimiluminescência (CMIA) e teste de ácido nucleico (NAT). As análises descritivas foram realizadas a partir de informações cadastradas no banco de dados do programa HEMOSYS da Fundação HEMOAM. Resultados: No período do estudo, um total de 172.867 candidatos a doação de sangue compareceram na Fundação HEMOAM. Destes, 0,8% (N=146) testaram positivo para o HIV. Entre estes, houve o predomínio de homens 77,4% (N=113), jovens entre 18 a 27 anos 39% (N=57), solteiros 52,1% (N=76), de raça parda 60,3% (N=88), com escolaridade ensino médio 40,4% (N=59). Em relação a coinfecção, verificou-se alta prevalência de HIV/sífilis com 26% (N=38) entre doadores de sangue, seguido pelo HIV/Hepatite C (HCV), sendo 3,4% (N=05). Não foram encontrados nenhuma coinfecção do HIV com o vírus da hepatite B, vírus linfotrópico de células T humanas HTLV, e Doença de chagas. Conclusão: Os resultados apresentados nesse estudo mostraram que os doadores de sangue infectados pelo HIV, eram adultos jovens, solteiros, do sexo masculino, pardos, com escolaridade ensino médio. Evidenciando que, este grupo necessita de mais políticas de educação e prevenção, ampliando a oferta de testes sorológicos para o HIV-1 nesta população. Os dados destacam a relevância da detecção da prevalência de coinfecções com o HIV em doadores de sangue, que podem subsidiar medidas de prevenção e de disseminação de infecção.
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Петров, А. В., e А. Н. Гаврилова. "ГЛИКИРОВАННЫЙ ГЕМОГЛОБИН И САМОКОНТРОЛЬ ГЛИКЕМИИ У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА – УЧАСТНИКОВ ШКОЛ ДИАБЕТА". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-105.
Abstract (sommario):
ЦЕЛЬ: изучить параметры компенсации углеводного обмена и связанные с ними факторы у пациентов,
проходивших обучение в школах диабета и иных образовательных мероприятиях РООИ «Нижегородская
диабетическая лига».
МАТЕРИАЛЫ И МЕТОДЫ: проведено анкетирование и оценка гликированного гемоглобина (НвА1с)
у 121 пациента с сахарным диабетом 2 типа, обучавшихся в школе диабета или участвовавших в одноднев-
ных образовательных мероприятиях РООИ «Нижегородская диабетическая лига». Оценивался анамнез
сахарного диабета и его терапии, самоконтроль. Данные приведены в формате M±SD, уровень статисти-
ческой значимости принят как р<0.05
РЕЗУЛЬТАТЫ: из 121 обследованного пациента 89% составили женщины, средний возраст 65±11,5 лет;
средняя длительность диабета 9±7,0 лет. 68% пациентов получали терапию метформином; 24% - препара-
тами сульфонилмочевины; 10% - глиптинами; 7,4% (9 чел.) – глифлозинами; 22% - препаратами инсулина.
Тест на гликированный гемоглобин был выполнен у 84 пациентов (69% обследованных), средний уро-
вень составил 7,6±1,94%. Доля пациентов с НвА1с >8% была равна 32%, эти пациенты не имели достовер-
ных отличий по возрасту (68±10,6 пр.63±13,5 лет, р=0,09) и, закономерно, отличались большей длительно-
стью диабета (12±6,7 пр. 7±6,6 лет, р=0,002). Из 11 мужчин НвА1с более 8% отмечался у 9 (82%), тогда как
среди женщин такое повышение было зарегистрировано в меньшинстве случаев (26%, р=0,0003). Среди
пациентов с уровнем НвА1с более 8% 30% получали инсулинотерапию, тогда как в группе с меньшими
значениями инсулинотерапия проводилась достоверно реже (7%, р=0,006).
По результатам опросника регулярный самоконтроль не менее 1 дня в неделю проводили 70% паци-
ентов, среди них 63% измеряли уровень гликемии как натощак, так и в течение дня. 57 пациентов (69%),
проводивших регулярный самоконтроль, сообщили при анкетировании данные о средних показателях
гликемии. В наибольшей степени с уровнем НвА1с коррелировал средний показатель гликемии при са-
моконтроле в течение дня (R=0.75 p<0.0001), для средней гликемии натощак коэффициент корреляции
был меньше (R=0.57 p<0.0001). Доля пациентов, проводивших регулярный самоконтроль, не отличалась
существенно между группами, разделенными по уровню НвА1с 8%. При этом у пациентов с высокими
уровнями НвА1с при самоконтроле регистрировались высокие значения гликемии – натощак 9,1±2,6 пр.
6,4±1,1 ммоль/л, р<0,0001; в течение дня 12,5±2,4 пр. 8,6±1,1 ммоль/л, р<0,0001.
ВЫВОДЫ: среди людей с диабетом 2 типа, принимавших участие в образовательных мероприятиях
региональной общественной организации пациентов с сахарным диабетом, плохой гликемический кон-
троль отмечался не менее чем в 1/3 случаев. Мужчины с сахарным диабетом в большей степени страдают
от низкого уровня знаний и мотивации в отношении сохранения здоровья, при этом имея низкий уровень
участия в обучении. Активное привлечение мужчин с сахарным диабетом 2го типа может являться одним
из приоритетов в организации обучения.
Значительная доля пациентов не осуществляет регулярного самоконтроля гликемии, однако даже при
его проведении сохраняется риск плохого управления гликемией, связанный, по-видимому, с инерцией
в интенсификации сахароснижающей терапии и игнорированием высоких показателей гликемии по дан-
ным самоконтроля.
Rapporti di organizzazioni sul tema "547.057 26":
1
Ramos-Rojas, José, Francisco Novillo, Daniel Nava, Camila Avila, Ana Rojas, Francisca Verdugo-Paiva, Gabriel Rada e Valentina Veloso. In patients with acute COVID-19, should remdesivir be used compared to placebo? Epistemonikos Interactive Evidence Synthesis, luglio 2023. http://dx.doi.org/10.30846/ies.sr1000.
Abstract (sommario):
The aim was to assess the efficacy of remdesivir in people with acute covid-19 compared with placebo. Eligible studies were randomised trials evaluating the effect of remdesivir versus placebo. We conducted searches in COVID-19 L·OVE (Living OVerview of Evidence) platform, a system that performs regular searches in databases, trial registries, preprint servers and websites relevant to COVID-19. All the searches covered the period until 06/23/2023. No date or language restrictions were applied. Two reviewers independently evaluated potentially eligible studies according to predefined selection criteria, and extracted data on study characteristics, methods, outcomes, and risk of bias, using a predesigned, standardised form. We performed meta-analyses using random-effect models and assessed overall certainty in evidence using the GRADE approach. Results: our search strategy yielded 132 references. 10 randomized controlled trials reported in 15 references met our inclusion criteria and were included in the review. The relative risk of mortality was 0.92 (95% CI 0.83 - 1.01). This means remdesivir reduced the risk of mortality in 8%, compared with placebo. In the studies identified in this review 762 people not receiving remdesivir out of 5340 presented the outcome Mortality (143 per 1000) versus 734 out of 5477 in the group that did receive it, with a risk difference of -12 per 1000 (from -24 to 1). In other words, -12 per 1000 (from -24 to 1) people did not develop the outcome because of the intervention. We assessed the certainty of the evidence for this outcome as low. The estimated absolute effect, -12 per 1000 (from -24 to 1), falls in the range of an effect of small magnitude. The relative risk of mechanical ventilation requirement was 0.71 (95% CI 0.41 - 1.24). This means placebo reduced the risk of mechanical ventilation requirement in 29%, compared with . In the studies identified in this review 189 people not receiving placebo out of 989 presented the outcome Mechanical ventilation requirement (191 per 1000) versus 182 out of 1195 in the group that did receive it, with a risk difference of -55 per 1000 (from -113 to 46). In other words, -55 per 1000 (from -113 to 46) people did not develop the outcome because of the intervention. We assessed the certainty of the evidence for this outcome as very low. The estimated absolute effect, -55 per 1000 (from -113 to 46), falls in the range of an effect of moderate magnitude. The relative risk of serious adverse events was 0.74 (95% CI 0.57 - 0.95). This means reduced the risk of serious adverse events in 26%, compared with . In the studies identified in this review 265 people not receiving out of 1238 presented the outcome Serious adverse events (214 per 1000) versus 256 out of 1401 in the group that did receive it, with a risk difference of -56 per 1000 (from -91 to -10). In other words, -56 per 1000 (from -91 to -10) people did not develop the outcome because of the intervention. We assessed the certainty of the evidence for this outcome as moderate. The estimated absolute effect, -56 per 1000 (from -91 to -10), falls in the range of an effect of moderate magnitude. Conclusions: Remdesivir may result in a slight reduction in Mortality. Remdesivir may reduce the Mechanical ventilation requirement but the evidence is very uncertain. Remdesivir probably results in a reduction in Serious adverse events.