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1

Hähner-Rombach, Sylvelyn, e Jörg Wagenblast. "Rezension von: Wagenblast, Jörg, Die Tübinger Militärpsychiatrie im Zweiten Weltkrieg". Zeitschrift für Württembergische Landesgeschichte 76 (23 febbraio 2022): 503–4. http://dx.doi.org/10.53458/zwlg.v76i.1908.

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Carrera de la Red, Avelina. "El Duodenarium (c. 1442) de Alfonso de Cartagena. Cultura castellana y letras latinas en un proyecto inconcluso, estudio, edición y traducción de Luis Fernández Gallardo y Teresa Jiménez Calvente, Córdoba, Editorial Almuzara, 2015". Minerva. Revista de Filología Clásica, n. 30 (12 novembre 2017): 383. http://dx.doi.org/10.24197/mrfc.30.2017.383-387.

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Reseña del libro El Duodenarium (c. 1442) de Alfonso de Cartagena. Cultura castellana y letras latinas en un proyecto inconcluso, estudio, edición y traducción de Luis Fernández Gallardo y Teresa Jiménez Calvente, Córdoba, Editorial Almuzara, 2015, 515 pp., ISBN: 978-84-16392-55-1
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Peever, Tobin L. "Lack of Correlation Between Fitness and Resistance to Sterol Biosynthesis-Inhibiting Fungicides inPyrenophora teres". Phytopathology 84, n. 5 (1994): 515. http://dx.doi.org/10.1094/phyto-84-515.

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4

Deeds, Susan M. "How to Write the History of the New World: Histories, Epistemologies, and Identities in the Eighteenth-Century Atlantic World". Hispanic American Historical Review 84, n. 3 (1 agosto 2004): 515–16. http://dx.doi.org/10.1215/00182168-84-3-515.

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5

Sandanayaka, W. R. M., L. K. Tooman e R. E. Hewett. "The impact of post acquisition period on detection of Candidatus Liberibacter solanacearum in tomato potato psyllid". New Zealand Plant Protection 66 (8 gennaio 2013): 365–73. http://dx.doi.org/10.30843/nzpp.2013.66.5712.

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The impact of post acquisition period (PAP) on detection of Candidatus Liberibacter solanacearum (Lso) in adult tomato potato psyllid (TPP; Bactericera cockerelli) was investigated using qPCR assays on whole insects Lso in adults was initially tested immediately after acquisition access periods (AAP) of 15 24 48 72 96 h or 1 week on Lsoinfected tomato leaves These results were compared with those from adults with 15 or 24 h AAP followed by 24 48 or 72h PAP on Lsofree tomato leaves From 1520 individuals of each treatment tested 515 were positive for Lso immediately after AAP of 15 or 24 h That increased to 84 and 100 with 24 and 48h PAPs respectively but decreased to 2547 after 72 h Longer AAP (48 h1 week) without PAP did not exceed 55 acquisition success The phloem ingestion and possible acquisition of Lso during 15 and 24 h plant access periods are discussed
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Tamura, K., N. Nagashima, H. Oda, M. Kunimi, T. Itoi, M. Yasukawa, T. Miyata e K. Terakado. "Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs". Veterinární Medicína 57, No. 10 (25 ottobre 2012): 529–35. http://dx.doi.org/10.17221/6364-vetmed.

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  The levels of rheumatoid factor (RF), antinuclear antibody (ANA), and composition of peripheral lymphocyte subsets in 515 dogs were examined. Of these sample cases, 33 cases were diagnosed as immune-mediated fever that presented with high C-reactive protein (CRP), 31 cases were diagnosed with Hansen’s Type 1 disc herniation and the remaining 415 cases were clinically healthy dogs, and served as controls. In the cases diagnosed with immune-mediated fever, 84% of the dogs tested positive to either RF or ANA (RF positive 60.6%; ANA positive 24.2%). By contrast, 16.2% of the healthy dogs were positive for either RF or ANA (RF positive 14.9%; ANA 1.3%). The CD4/CD8 ratio for peripheral lymphocyte was high for all analysed cases diagnosed with immune-mediated fever, and was significantly higher than those of healthy controls. These results indicate that the abnormal levels of lymphocytes may be an effective indicator for immune-mediated disease coupled to immune-mediated fever.  
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Lee, S. E., e S. H. Kang. "Estimating the GIS-based soil loss and sediment delivery ratio to the sea for four major basins in South Korea". Water Science and Technology 68, n. 1 (1 luglio 2013): 124–33. http://dx.doi.org/10.2166/wst.2013.194.

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This paper describes a sediment delivery ratio (SDR) using the Geographic Information System (GIS)-based Revised Universal Soil Loss Equation (RUSLE), to calculate the soil loss and sediment rating curve (SRC) basis of measured data in the six basins of Four Rivers, South Korea. The data set for calculating SDR was prepared during 3 years from 2008 to 2010. Mean soil loss in the six basins of Four Rivers was 515–869 t km−2 yr−1 and mean specific sediment yield (SSY) was 20–208 t km−2 yr−1 with basin size. The SDR ranged from 0.03 to 0.33 in the six rivers. Most sediment flows in the monsoon period from June to September (mean Max.: >97%; mean Min.: >84%), but SDR is lower than those of similar continental river basins. This is due to environmental factors, for example rainfall characteristics and associated run-off, soil characteristics and cultivated patterns with increasing basin size. This research provides the first application of SDR based on the observed field data in South Korea.
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Larkin, Denis M., Annelie Everts-van der Wind, Mark Rebeiz, Peter A. Schweitzer, Sharon Bachman, Cheryl Green, Chris L. Wright et al. "A Cattle–Human Comparative Map Built with Cattle BAC-Ends and Human Genome Sequence". Genome Research 13, n. 8 (agosto 2003): 1966–72. http://dx.doi.org/10.1101/gr.1560203.

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As a step toward the goal of adding the cattle genome to those available for multispecies comparative genome analysis, 40,224 cattle BAC clones were end-sequenced, yielding 60,547 sequences (BAC end sequences, BESs) after trimming with an average read length of 515 bp. Cattle BACs were anchored to the human and mouse genome sequences by BLASTN search, revealing 29.4% and 10.1% significant hits (E < e-5), respectively. More than 60% of all cattle BES hits in both the human and mouse genomes are located within known genes. In order to confirm in silico predictions of orthology and their relative position on cattle chromosomes, 84 cattle BESs with similarity to sequences on HSA11 were mapped using a cattle–hamster radiation hybrid (RH) panel. Resulting RH maps of BTA15 and BTA29 cover ∼85% of HSA11 sequence, revealing a complex patchwork shuffling of segments not explained by a simple translocation followed by internal rearrangements. Overlay of the mouse conserved syntenies onto HSA11 revealed that segmental boundaries appear to be conserved in all three species. The BAC clone-based comparative map provides a foundation for the evolutionary analysis of mammalian karyotypes and for sequencing of the cattle genome.
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Mateo-Seco, Lucas F. "Félix María AROCENA, Sol Salutis. La Navidad en la liturgia mozárabe y romana, Regina, Barcelona 2002, 255 pp., 14 x 21, ISBN 84-7129-515-6." Scripta Theologica 35, n. 2 (22 novembre 2017): 627. http://dx.doi.org/10.15581/006.35.13165.

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KRENTZ, PETER. "(C.J.) Tuplin (ed.) Xenophon and his World. (Historia Einzelschriften 172.) Pp. 524, maps, pls. Stuttgart: Franz Steiner Verlag, 2004. Cased, €84. ISBN: 3-515-08392-8." Classical Review 56, n. 2 (ottobre 2006): 301–3. http://dx.doi.org/10.1017/s0009840x06001600.

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Wells, Anita S., Nicholas W. Read, Chris Idzikowski e Jane Jones. "Effects of meals on objective and subjective measures of daytime sleepiness". Journal of Applied Physiology 84, n. 2 (1 febbraio 1998): 507–15. http://dx.doi.org/10.1152/jappl.1998.84.2.507.

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Wells, Anita S., Nicholas W. Read, Chris Idzikowski, and Jane Jones. Effects of meals on objective and subjective measures of daytime sleepiness. J. Appl. Physiol. 84(2): 507–515, 1998.—Effects of recent food ingestion on daytime sleepiness were assessed in 16 subjects (8 men and 8 women) who were each studied on two occasions, 28 days apart. On each occasion, subjects ate a high-fat low-carbohydrate (CHO) (fat/CHO energy ratio 54:41) meal and an isoenergetic low-fat high-CHO meal (fat/CHO energy ratio 7:88) 4 h apart in a counterbalanced order. Sleepiness was measured at 2-h intervals by using the Multiple Sleep Latency Test and the Akerstedt electroencephalograph sleepiness test. To control for circadian factors, one group (4 men, 4 women) ate the meals 2 h later than did the other group of subjects. There were no differences in sleepiness according to the composition of the meal. Sleepiness in the Multiple Sleep Latency Test was significantly greater 1.5 h after the meals were eaten than before ( F 11.37; df 1,15; P = 0.004). Sleepiness was also enhanced in the Akerstedt sleepiness test 3 h 20 min after the meals. The results suggest that the meals induced an enhancement in sleepiness that was not solely due to circadian rhythms.
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Verrina, Enrico, Francesco Perfumo, Graziella Zacchello, Alberto Edefonti, Sergio Bassi, Giovanni Capasso, Domenica A. Caringella et al. "Chronic Peritoneal Dialysis Catheters in Pediatric Patients: Experience of the Italian Registry of Pediatric Chronic Peritoneal Dialysis". Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 13, n. 2_suppl (gennaio 1993): 254–56. http://dx.doi.org/10.1177/089686089301302s63.

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During the period 1986–1991, 140 pediatric patients [age≤15 years at the start of chronic peritoneal dialysis (CPD)], belonging to 15 dialysis centers, were enrolled In the Italian Registry of Pediatric Chronic Peritoneal Dlaly 515. Data on 188 peritoneal catheters were collected: 161 catheters were Tenckhoff (144 double-cuff, 17 singlecuff), and 27 were two-cuff Valll-type catheters. All catheters were surgically inserted; the entry site was in the midline In 84 cases and paramedian in 104. An omentectomy was performed in 78.80/0 of the cases. Apart from peritonitis, there were 161 catheter-related complications (103 exit-site infections, 17 leakages, 15 obstructions, 15 outer-cuff extrusions, 5 hemoperltoneum, 6 others) observed during 2687.5 dialysis-months, with an Incidence of one complication every 16.7 dialysis months. Fifty-five catheters (29.2%) were removed; infection (39 cases) was the main cause for removal, followed by obstruction (9 cases), dislocation, and outer-cuff extrusion (2 cases each). Actuarial survival of all catheters was 79.7% at 1 year, 66.6% at 2 years, 42.8% at 3 years, and 39.80/0 at 4 years. No difference In catheter survival was observed according to the entry site. When considering the age of the patients at catheter insertion, a difference close to statistical significance was found (p=0.06).
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Burton, Alison L., Brent A. Roach, Michael P. Mays, Andrea F. Chen, Brooke A. R. Ginter, Abbey M. Vierling, Charles R. Scoggins et al. "Prognostic Significance of Tumor Infiltrating Lymphocytes in Melanoma". American Surgeon 77, n. 2 (febbraio 2011): 188–92. http://dx.doi.org/10.1177/000313481107700219.

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The prognostic significance of tumor infiltrating lymphocyte (TIL) response in cutaneous melanoma is controversial. This analysis of data from a prospective, randomized trial included patients with cutaneous melanoma ≥ 1.0 mm Breslow thickness who underwent wide local excision and sentinel lymph node (SLN) biopsy. Univariate and multivariate analyses were performed to determine factors associated with TIL response, disease-free survival (DFS), and overall survival (OS). A total of 515 patients were included; TIL response was classified as “brisk” (n = 100; 19.4%) or “non-brisk” (n = 415; 80.6%). Patients in the nonbrisk TIL group were more likely to have tumor-positive SLN (17.6% vs 7%; P = 0.0087). On multivariate analysis, nonbrisk TIL response, increased tumor thickness, and ulceration were significant independent predictors of tumor-positive SLN. By Kaplan-Meier analysis, 5-year DFS rate was 91 per cent for those with a brisk TIL response compared with 86 per cent in the nonbrisk group ( P = 0.41). The 5-year OS rates were 95 per cent versus 84 per cent in the brisk versus nonbrisk TIL groups, respectively ( P = 0.0083). However, on multivariate analysis, TIL response was not a significant independent factor predicting DFS or OS. TIL response is a significant predictor of SLN metastasis but is not a major predictor of DFS or OS.
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Suryana, Asep, e Asep Achmad Rifa'i. "Keputusan Pembelian dan Harga Jual". Formosa Journal of Applied Sciences 1, n. 5 (31 ottobre 2022): 789–98. http://dx.doi.org/10.55927/fjas.v1i5.1591.

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Tujuan dari penelitian ini adalah untuk mengetahui proyeksi keputusan harga beli usaha mikro dan kecil (UMK) isi ulang gas oksigen medis (O2) pada CV. Sukabumi Centra Gas. Desain dalam penelitian ini menggunakan metode penelitian deskriptif dan metode asosiatif dengan pendekatan kuantitatif, dengan metode survei. Populasi dalam penelitian ini adalah seluruh konsumen warung masyarakat yang pernah isi ulang gas dari Arpil - Juli 2022 sebanyak 515 orang, sampel yang digunakan adalah 84 responden yang diperoleh dengan menggunakan metode nonprobability sampling dengan teknik Slovin. Untuk menguji analisis dalam penelitian ini digunakan uji validitas instrumen, uji reliabilitas instrumen, analisis deskriptif, kemudian dilakukan uji analisis statistik untuk analisis hubungan dan pengaruh analisis korelasi, analisis koefisien determinasi, linier sederhana dan uji hipotesis statistic, menggunakan uji t. Hasil diketahui bahwa Tingkat keeratan harga dengan keputusan pembelian sebesar 0,753, artinya hubungan kedua variabel berada pada tingkat hubungan yang kuat dan searah. Hasil perhitungan dan analisis koefisien determinasi (r2) menunjukkan bahwa harga berpengaruh positif terhadap keputusan pembelian, sehingga hipotesis yang diajukan dalam penelitian ini terbukti dapat diterima. Besarnya kontribusi pengaruhnya terhadap Keputusan Pembelian adalah 56,7%, implikasinya sebesar 43,3% adalah sisanya dipengaruhi oleh variabel lain yang tidak diteliti di luar model. Temuan akhir penelitian ini, diketahui bahwa Keputusan Pembelian secara signifikan dipengaruhi oleh harga jual.
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Salifou, Saliou, Daméga Wenkourama, Mawuko Gbétogbé, Sonia Kanékatoua, Charfoundine Affo, Bikiénime Biyante-Afeto, Mayéna Kpinsaga e Kolou Simliwa Dassa. "Deux ans de pratiques psychiatriques à la Clinique Médico-Psychiatrique de Lomé : bilan". Psy Cause N° 80, n. 1 (3 gennaio 2022): 41–48. http://dx.doi.org/10.3917/psca.080.0041.

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Introduction : Au Togo, depuis quelques décennies, la fréquentation des structures de prise en charge psychiatrique est sans cesse croissante et la Clinique Médico-Psychiatrique de Lomé (une clinique privée) a vu le jour il y a deux ans. Le but de cette étude était de faire un bilan panoramique des pratiques psychiatriques de la Clinique Médico-Psychiatrique de Lomé. Matériel et méthode. Il s’est agi d’une étude rétrospective et descriptive portant sur les patients reçus du 3 février 2020 au 31 janvier 2022 à la Clinique Médico-Psychiatrique de Lomé. Résultats. Au cours de la période d’étude, 515 patients ont été suivis à la CMP-L. Le sexe féminin a représenté 52,43 % des patients. L’âge moyen des patients était de 36,59 ans ± 15,27 avec des extrêmes de 05 ans et 84 ans. Les fonctionnaires/ opérateurs économiques ont représenté 44,66 % des patients. Les motifs de consultation les plus fréquents étaient l’insomnie (34,17 %), l’agitation (21,17 %) et le délire (20,39 %). Les troubles de l’humeur ont prédominé chez nos patients (le trouble bipolaire à 28,35 % et le trouble dépressif à 20,97 %). Conclusion. Première et seule clinique psychiatrique privée au Togo, la CMP-L se devait de fournir des données scientifiques exploitables après deux ans d’exercice.
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Lin, Michael. "Support overlapping $L_{1}$ contractions and exact non-singular transformations". Colloquium Mathematicum 84, n. 2 (2000): 515–20. http://dx.doi.org/10.4064/cm-84/85-2-515-520.

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Huizink, Lies. "Messner, Angelika G: Medizinische Diskurse zu Irresein in China (1600-1930). Stuttgart, Steiner, 2000.294 S. Iii. (Münchener Ostasiatische Studien, 78). SFr. 84.-. ISBN 3-515-07548-8." Gesnerus 59, n. 1-2 (3 dicembre 2002): 138. http://dx.doi.org/10.1163/22977953-0590102032.

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PARKER, ROBERT. "(A.) Kledt Die Entführung Kores. Studien zur athenisch–eleusinischen Demeterreligion. (Palingenesia 84.) Pp. 204. Stuttgart: Franz Steiner Verlag, 2004. Cased, €45. ISBN: 978-3-515-08615-8." Classical Review 57, n. 2 (3 settembre 2007): 561. http://dx.doi.org/10.1017/s0009840x07001473.

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Dieterich, Sven, Christian Grebe, Christoph Bräutigam, Rüdiger Hoßfeld, Änne-Dörte Latteck, Anke Helmbold, Stefan Heim et al. "Verbleib der Absolventinnen und Absolventen der Modellstudiengänge in den Gesundheitsfachberufen in Nordrhein-Westfalen: Ergebnisse zu Beschäftigungsmerkmalen und Kompetenzen in der Berufspraxis". Das Gesundheitswesen 82, n. 11 (13 ottobre 2020): 920–30. http://dx.doi.org/10.1055/a-1241-3983.

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Zusammenfassung Ziel Ziel des Artikels ist es, zentrale Ergebnisse aus der landesweiten Studie zum Verbleib der Absolventen aus den 12 Modellstudiengängen in den Gesundheitsfachberufen in Nordrhein-Westfalen zu referieren. Untersuchungsziel der Studie ist es, den beruflichen Verbleib nach dem Abschluss eines berufsqualifizierenden Modellstudiums zu beschreiben und Merkmale sowie Rahmenbedingungen der beruflichen Situation darzustellen. Im Mittelpunkt des Artikels stehen Erkenntnisse zu den Merkmalen der Haupterwerbstätigkeit der Absolventen und zur Anwendung der im Studium vermittelten Kompetenzen im Berufsalltag. Methodik Insgesamt 515 Absolventen aus den Modellstudiengängen Pflege (N=244), Physiotherapie (N=97), Logopädie (N=95), Ergotherapie (N=47) und Hebammenkunde (N=32) haben sich im Frühsommer 2018 an einer Online-Querschnitt-Befragung beteiligt. In die Befragung eingeschlossen waren alle Abschlussjahrgänge zwischen Wintersemester 2013/2014 und Sommersemester 2017. Ergänzend wurden Arbeitgeber (N=109) befragt, die Absolventen aus den genannten Studiengängen eingestellt haben. Ergebnisse Die Absolventen sind v. a. im Krankenhaus und in ambulanten Therapiepraxen tätig. Acht von 10 Absolventen (84%) erbringen vornehmlich klientennahe Aufgaben. 71% dieser klientennah arbeitenden Absolventen erbringen im Vergleich zu fachschulisch ausgebildeten Personen ergänzend besondere Aufgaben. Die Absolventen schätzen sich in allen untersuchten Kompetenzdimensionen durchschnittlich als handlungssicher ein. Die Arbeitgeber nehmen in allen Kompetenzdimensionen bei den Absolventen einen „Kompetenzvorsprung“ im Vergleich zu fachschulisch Ausgebildeten wahr. Schlussfolgerungen Die Resultate der Verbleibstudie unterstützen die Empfehlung, die Studiengänge aller untersuchten Gesundheitsfachberufe berufsgesetzlich zu verankern und ihren Regelbetrieb an den Hochschulen einzuführen.
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Nenasheva, N. M., B. B. Buriev, N. M. Nenasheva e B. B. Buriev. "Features of atopic bronchial asthma in adults: treatment and control". Russian Journal of Allergy 6, n. 4 (15 dicembre 2009): 12–16. http://dx.doi.org/10.36691/rja1024.

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Background. To study the age and gender structure, as well as clinical and functional characteristics and level of control of atopic bronchial asthma in adults. Materials and methods. An analysis of 515 outpatient records of patients with bronchial asthma (BA) was done. Two hundred persons were interviewed by phone to evaluate the current condition of BA. The questionnaires were used included as issues related to current asthma condition during the past year as treatment and control of BA. ACT-test was used to evaluate of the control of the BA. Results. 402 patients (78%, CI: 74-81%) had an atopic form of BA, 103 (20%, CI: 16-23%) - a non-atopic BA and 10 (2%, CI: 1-3%) - both an atopic and a non-atopic forms of BA. Young individuals dominated (66,4%, CI: 62-71%) among patients with an atopic BA. Men (82%, CI: 77-86%) prevailed among young people, while women were in majority in the old group. The most significant allergens in patients with atopic BA for residents of the Moscow region were house dust (363 - 90%, CI: 87-92%) and house dust mites - in 328 patients (81,6%, CI: 77-85%). The tree pollen (51,7%, CI: 47-56%) was the most spread among the pollen allergy. The results of the interactive poll showed that 43% (CI: 36-50%) of BA patients had uncontrolled asthma. Most of patients (79,5%, CI: 73%-84%) noted exacerbations of BA in the past year, among them about 10% (CI: 6-15%) were treated in a hospital, while 8% (CI: 5-13%) - resorted to the emergency help. Conclusion. Atopic BA is 78% (CI: 74-81%) of the total number of adult patients with asthma, the majority of patients (65,7%, CI: 60-70%) had mild disease. The combination of atopic BA and allergic rhinitis had the 98% (CI: 96-99%) of patients. 43% (CI: 36-50%) patients noted uncontrolled asthma according to the ACT-test. 79,5% (CI: 73-84%) of patients had exacerbations of BA during the past year due to the inadequate treatment.
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Rodríguez, Carlos Larrinaga. "Manuel González Portilla (ed.): Los orígenes de una metrópoli industrial: la ría de Bilbao, 2 vols., Bilbao, Fundación BBVA, 2001, 515 y 612 pp. ISBN: 84-95163-57-8." Revista de Historia Económica / Journal of Iberian and Latin American Economic History 20, n. 2 (settembre 2002): 395–98. http://dx.doi.org/10.1017/s0212610900009903.

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Brown, G. P., e R. C. Venuto. "Angiotensin II receptor alterations during pregnancy in rabbits". American Journal of Physiology-Endocrinology and Metabolism 251, n. 1 (1 luglio 1986): E58—E64. http://dx.doi.org/10.1152/ajpendo.1986.251.1.e58.

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Despite activation of the renin-angiotensin system during pregnancy, renal and peripheral vascular blood flows increase, and the systemic blood pressure and the pressor response to exogenous angiotensin II (Ang II) fall. Gestational alterations in Ang II receptors could contribute to these changes. Ang II binding parameters were determined utilizing 125I-Ang II in vascular (glomeruli and mesenteric arteries) and nonvascular (adrenal glomerulosa) tissues from 24- to 28-day pregnant rabbits. Comparisons were made utilizing tissues from nonpregnant rabbits. Binding site concentrations (N) and dissociation constants (Kd) were obtained by Scatchard analyses of binding inhibition data. In glomeruli from nonpregnant and pregnant rabbits, N was 515 +/- 84 and 300 +/- 54 fmol X mg-1 protein (P less than 0.005; n = 8), respectively. Kd did not differ (P greater than 0.05). In mesenteric artery membranes from nonpregnant (n = 3) and pregnant (n = 4) rabbits, N was 304 +/- 21 and 112 +/- 23 fmol X mg-1 (P less than 0.005), respectively. Kd did not differ. Neither N nor Kd differed in adrenal glomerulosa tissues (n = 6). Meclofenamate (M) inhibits prostaglandin synthesis, reduces plasma renin activity, and enhances the pressor response to infused Ang II in pregnant rabbits. Administration of M to pregnant rabbits increased N in glomerular and in mesenteric artery membranes from 298 +/- 16 to 381 +/- 8 fmol X mg-1 (n = 3) and from 144 +/- 13 to 218 +/- 13 fmol X mg-1 (n = 4), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
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MORRIS, ANDREW, RUTH WELSH, RICHARD FRAMPTON, JUDE CHARLTON e BRIAN FILDES. "Vehicle crashworthiness and the older motorist". Ageing and Society 23, n. 4 (25 giugno 2003): 395–409. http://dx.doi.org/10.1017/s0144686x03001223.

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This study examines the relationship between age and the injury outcomes for belted drivers in road vehicle crashes in the United Kingdom. The sample of 1,541 drivers was divided into three age groups: 889 drivers were aged 17–39 years (young drivers); 515 were 40–64 years (middle-aged), and 137 aged 65–84 years (older drivers). Both frontal and side impact crashes in which the vehicles sustained sufficient damage to be towed away from the scene are considered. In-depth information obtained from examinations of the crashed vehicles was combined with clinical data obtained from hospitals to throw light on the mechanisms that led to the injuries. Results show that in crashes of approximately equal severity, older drivers were significantly more likely than middle-aged and young drivers to be fatally injured in both frontal (p<0.001) and side (p<0.05) impact crashes. The results also show that older drivers sustained more injuries to the chest (p<0.0001) and that this body region is particularly problematic. The main sources of the chest injuries were found to be the seat belt in frontal crashes and the door in side impact crashes. As the number of older car users will increase rapidly in most OECD countries in the coming decades, the results suggest that vehicle re-designs are required, including in-vehicle crashworthiness systems, to take into account older people's relatively low tolerance of crash impacts.
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Carcauzon, Victoria, James P. Herrera, Kayla Kaufman, Fiona Baudino, Natalie Wickenkamp, Toky M. Randriamoria, Voahangy Soarimalala et al. "Astroviruses in terrestrial Malagasy mammals". PLOS Neglected Tropical Diseases 18, n. 6 (14 giugno 2024): e0012263. http://dx.doi.org/10.1371/journal.pntd.0012263.

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Small terrestrial mammals are major hosts of infectious agents responsible for zoonotic diseases. Astroviruses (AstVs)–the cause of non-bacterial gastroenteritis mainly affecting young children–have been detected in a wide array of mammalian and avian host species. However, understanding the factors that influence AstV infection within and across hosts is limited. Here, we investigated the impact of land use changes on AstVs in terrestrial small mammals in rural northeastern Madagascar. We sampled 515 small mammals, representing seven endemic and four introduced species. Twenty-two positive samples were identified, all but one of which were found in the introduced species Mus musculus and Rattus rattus (family Muridae), with a positivity rate of 7.7% (6/78) and 5.6% (15/266), respectively. The non-introduced rodent case was from an endemic shrew-tenrec (family Tenrecidae). We found the highest positivity rate of AstVs infection in brushy regrowth (17.5%, 7/40) as compared to flooded rice fields (4.60%, 8/174), secondary forest (4.1%, 3/74), agroforest (3.6%, 1/28), village (2.61%, 3/115), and semi-intact forest (0%, 0/84). A phylogenetic analysis revealed an association between AstVs and their rodent host species. None of the viruses were phylogenetically related to AstVs previously described in Malagasy bats. This study supports AstV circulation in synanthropic animals in agricultural habitats of Madagascar and highlights the need to assess the spillover risk to human populations in rural areas.
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Morales, Juan José. "RESEÑA de: Alvarado Planas, Javier. Masones en la Nobleza de España : una hermandad de iluminados. Madrid: La Esfera de los Libros, 2016. 515 páginas. ISBN: 978-84-9060-575-2." Revista de Derecho de la UNED (RDUNED), n. 19 (1 luglio 2016): 905. http://dx.doi.org/10.5944/rduned.19.2016.18470.

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Sarro-Maluquer, Ramón. "A. Martín del Molino, Los Bubís: ritos y creencias. Malabo (Bioko): Centre Cultural Hispano-Guineano (with Institut de Cooperación para el Desarrollo, Madrid), 1989, 510 pp., ISBN 84 7232 515 6." Africa 60, n. 4 (ottobre 1990): 578. http://dx.doi.org/10.2307/1160224.

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Doghmane, Houssem Eddine, Fatiha Challali, Tahar Touam, Azeddine Chelouche e Djamel Djouadi. "Radio Frequency Magnetron Sputtering Growth of Titanium Dioxide Thin Films: Effects of Substrate Temperature on Microstructural and Optical Properties". Journal of Nano Research 70 (25 ottobre 2021): 1–14. http://dx.doi.org/10.4028/www.scientific.net/jnanor.70.1.

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Titanium dioxide thin films were deposited by radio frequency sputtering on glass substrates at different substrate temperatures. Hence, we first optimized the preparation conditions and parameters which offer better control and reproducibility of film fabrication. Then, we investigate the structural, morphological and optical properties of the prepared titanium dioxide thin films. To do so, we used several characterization techniques: X-ray diffraction, Raman spectroscopy, scanning electron microscopy, atomic force microscopy and ultraviolet-visible spectroscopy. Interesting results were obtained, e.g. X-ray diffraction analysis shows that the films crystallize only in the anatase tetragonal structure with a preferential orientation along the (101) plane. The intensity of the (101) diffraction peak and the crystallite size are found to increase with increasing substrate temperature, indicating a crystallinity improvement of the films. Raman peaks observed around 144, 197, 399, 515 and 639 cm−1 confirm that all samples possess anatase phase and the crystallinity is enhanced with increasing substrate temperatures. The analysis of scanning electron microscopy and atomic force microscopy images demonstrates that increasing the substrate temperature significantly affects the morphology, grain size and surface roughness of TiO2 films. The ultraviolet-visible spectroscopy analysis put into evidence that the film deposited at RT is highly transparent in the visible region with average transmittance greater than 84%. Higher substrate temperatures result in a slight decrease of transmittance. Moreover, the direct optical band gap decreases while the refractive index increases with increasing the substrate temperature. Thus, the obtained results reveal that ultraviolet-visible can be considered as a potential material for optical and photovoltaic applications.
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Kingshott, Ruth N., Florian Gahleitner, Heather E. Elphick, Paul Gringras, Michael Farquhar, Ruth M. Pickering, Jane Martin et al. "Cardiorespiratory sleep studies at home: experience in research and clinical cohorts". Archives of Disease in Childhood 104, n. 5 (19 novembre 2018): 476–81. http://dx.doi.org/10.1136/archdischild-2018-315676.

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ObjectiveTo evaluate the success rates of home cardiorespiratory polygraphy in children under investigation for sleep-disordered breathing and parent perspectives on equipment use at home.DesignProspective observational study.SettingSheffield, Evelina London and Southampton Children’s Hospitals.PatientsData are reported for 194 research participants with Down syndrome, aged 0.5–5.9 years across the three centres and 61 clinical patients aged 0.4–19.5 years from one centre, all of whom had home cardiorespiratory polygraphy including respiratory movements, nasal pressure flow, pulse oximetry, body position and motion.Main outcome measuresPercentage of home cardiorespiratory studies successfully acquiring ≥4 hours of artefact-free data at the first attempt. Parental report of ease of use of equipment and preparedness to repeat home diagnostics in the future.Results143/194 (74%; 95% CI 67% to 79%) of research participants and 50/61 (82%; 95% CI 71% to 90%) of clinical patients had successful home cardiorespiratory polygraphy at the first attempt. Some children required multiple attempts to achieve a successful study. Overall, this equated to 1.3 studies per research participant and 1.2 studies per clinical child. The median artefact-free sleep time for successful research studies was 515 min (range 261–673) and for clinical studies 442 min (range 291–583). 84% of research and 87% of clinical parents expressed willingness to repeat home cardiorespiratory polygraphy in the future. 67% of research parents found the equipment ‘easy or okay’ to use, while 64% of clinical parents reported it as ‘easy’ or ‘very easy’.ConclusionsHome cardiorespiratory polygraphy offers an acceptable approach to the assessment of sleep-disordered breathing in children.
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Tindale, Alexander, e Vasileios Panoulas. "The BE-ALIVE score: assessing 30-day mortality risk in patients presenting with acute coronary syndromes". Open Heart 10, n. 2 (agosto 2023): e002313. http://dx.doi.org/10.1136/openhrt-2023-002313.

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AimTo create and validate a simple scoring system for predicting 30-day mortality in patients presenting with acute coronary syndromes (ACS) at their moment of admission.Methods and results2407 consecutive patients presenting to Harefield Hospital with measured arterial blood gases, from January 2011 to December 2020, were studied to build the training set. 30-day mortality in this group was 17.2%. A scoring algorithm that was built using binary logistic regression of variables available on admission was then converted to an additive risk score. The resultant scoring system is the BE-ALIVE score, which incorporates the following factors:Base Excess (1 point for <−2 mmol/L), Age (<65 years: 0 points, 65–74: 1 point, 75–84: 2 points, ≥85: 3 points), Lactate (<2 mmol/L: 0 points, 2–4.9: 1 point, 5–9.9: 3 points, ≥10: 6 points), Intubated (2 points), Left Ventricular function (mildly impaired or better: −1 point, moderately impaired: 1 point, severely impaired: 3 points) and External/out of hospital cardiac arrest 2 points).The scoring system was validated using a testing set of 515 patients presenting to Harefield Hospital in 2021. The validation metrics were excellent with a c-statistic of 0.9, Brier’s score 0.06 vs a naïve classifier of 0.15, Spiegelhalter’s z-statistic probability of 0.267 and a calibration slope of 1.08.ConclusionThe BE-ALIVE score is a simple and accurate scoring system to predict 30-day mortality in patients presenting with ACS. Appreciating this mortality risk can allow prompt involvement of appropriate care such as the shock team.
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Mueliana, Ika Fitri, Siti Aisyah e Merisa Riski. "Faktor-Faktor yang Berhubungan dengan Perilaku Seksual Pranikah Pada Remaja di SMA X Kecamatan Lempuing OKI Tahun 2021". Jurnal Ilmiah Universitas Batanghari Jambi 22, n. 1 (19 febbraio 2022): 188. http://dx.doi.org/10.33087/jiubj.v22i1.1919.

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Premarital sexual behavior is behavior related to sexual urges with the opposite sex or same sex that is carried out before the existence of a legal marriage bond. WHO states that in developing countries 21 million adolescent girls aged 15-19 years experience pregnancy each year and 49% of pregnancies are unwanted. The IDHS (2017) states that adolescents aged 15-24 years holding hands: Women 64% Men 75%, Kissing lips: Women 30% Men 50%, Hugging: Women 17% Men 33%, likes 82% and loves each other 83% . In Palembang City, 456 teenagers became pregnant out of wedlock and 159 gave birth to health workers. In SMA X Lemrub the results of interviews with 10 students have been in a relationship and sent romantic words, 6 teenagers have walked hand in hand, 2 have hugged, kissed. The purpose of this study was to determine the relationship between parenting, smartphone use, and socioeconomic with premarital sexual behavior in adolescents. This type of research is quantitative with an analytical survey method with a cross sectional approach. The population in this study were 515 students in class X, XI and XII with 84 samples taken by random sampling. Primary data were processed and analyzed by univariate and bivariate analysis and Chi-Square test. The results and conclusions found the relationship between parental parenting with Pvalue = 0.002, smartphone use Pvalue = 0.000 and socio-economic Pvalue = 0.050 with premarital sexual behavior in adolescents at SMA X Lemrub OKI. It is hoped that the results of this study can be used as input for making effective school regulations for adolescents to prevent premarital sexual behavior in adolescents
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Li, Chunyan, Eddie Weeks, Wei Huang, Brian Milan e Renhao Wu. "Weather-Induced Transport through a Tidal Channel Calibrated by an Unmanned Boat". Journal of Atmospheric and Oceanic Technology 35, n. 2 (febbraio 2018): 261–79. http://dx.doi.org/10.1175/jtech-d-17-0130.1.

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AbstractAn unmanned surface vehicle (USV) was designed and constructed to operate continuously for covering both flood and ebb and preferably a complete tidal cycle (e.g., ~24 h) to measure the vertical profiles of horizontal flow velocity. It was applied in a tidal channel at Port Fourchon, Louisiana. A bottom-mounted ADCP was deployed for 515 days. The first EOF mode of the velocity profiles showed a barotropic type of flow that explained more than 98.2% of the variability. The second mode showed a typical estuarine flow with two layers, which explained 0.47% of the variability. Using a linear regression of the total transport from the USV with the vertically averaged velocity from the bottom-mounted ADCP, with an R-squared value of 98%, the total along-channel transport throughout the deployment was calculated. A low-pass filtering of the transport allowed for examining the impact of 76 events with cold, warm, or combined cold–warm fronts passing the area. The top seven most severe events were discussed, as their associated transports obviously stood out in the time series, indicating the importance of weather. It is shown that large-scale weather systems with frontal lines of ~1500–3000-km horizontal length scale control the subtidal transport in the area. Cold (warm) fronts tend to generate outward (inward) transports, followed by a rebound. The maximum coherence between the atmospheric forcing and the ocean response reached ~71%–84%, which occurred at about a frequency f of ~0.29 cycle per day or T of ~3.4 days in the period, consistent with the atmospheric frontal return periods (~3–7 days).
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32

Essani, N. A., M. L. Bajt, A. Farhood, S. L. Vonderfecht e H. Jaeschke. "Transcriptional activation of vascular cell adhesion molecule-1 gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock." Journal of Immunology 158, n. 12 (15 giugno 1997): 5941–48. http://dx.doi.org/10.4049/jimmunol.158.12.5941.

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Abstract Polymorphonuclear leukocytes (neutrophils) can cause hepatic parenchymal cell injury during endotoxin (ET) shock. Because adhesion molecules are critical for inflammatory cell damage, the role of vascular cell adhesion molecule-1 (VCAM-1) was studied in the pathophysiology of ET shock. ET-sensitive mice (C3Heb/FeJ) were treated with 700 mg/kg galactosamine in combination with 100 microg/kg Salmonella abortus equi ET, 15 microg/kg TNF-alpha, or 13 to 23 microg/kg IL-1. VCAM-1 mRNA formation was strongly activated in animals treated with ET, TNF-alpha, or IL-1. In contrast, only TNF-alpha and IL-1, not ET, induced VCAM-1 gene transcription in livers of ET-resistant mice (C3H/HeJ). Immunohistochemistry and isolation of liver cells during endotoxemia indicated that VCAM-1 mRNA and protein were only formed in endothelial cells and Kupffer cells, not in hepatocytes. Galactosamine/ET induced neutrophil accumulation in sinusoids (515 +/- 30 neutrophils/50 high power fields) followed by transmigration at 7 h. At that time, severe liver injury was observed (necrosis, 53 +/- 5%). An anti-VCAM-1 Ab (3 mg/kg) attenuated the area of necrosis by 60%. The Ab reduced neutrophil transmigration by 84%, but had no effect on the total number of cells in the liver vasculature. Flow cytometric analysis identified the presence of very late Ag-4 on mouse peripheral neutrophils. Our data demonstrated cytokine-dependent VCAM-1 gene transcription and protein expression in the liver during endotoxemia. Neutrophils were able to use very late Ag-4/VCAM-1 interactions to transmigrate into liver parenchyma in vivo. Preventing transmigration by blocking VCAM-1 protected hepatocytes against neutrophil-induced injury.
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Ogereau, Julien M. "Katharina Bolle, Carlos Machado and Christian Witschel, eds.: The Epigraphic Cultures of Late Antiquity, Heidelberger Althistorische Beiträge und Epigraphische Studien 60, Stuttgart (Franz Steiner) 2017, 615 pp., ISBN 978-3-515-11558-2, € 84,–." Zeitschrift für Antikes Christentum / Journal of Ancient Christianity 22, n. 2 (3 settembre 2018): 342–46. http://dx.doi.org/10.1515/zac-2018-0021.

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34

Lee, Chee Khoon, Lucy Davies, Val J. Gebski, Sarah J. Lord, Angelo Di Leo, Stephen Johnston, Charles Geyer et al. "Serum Human Epidermal Growth Factor 2 Extracellular Domain as a Predictive Biomarker for Lapatinib Treatment Efficacy in Patients With Advanced Breast Cancer". Journal of Clinical Oncology 34, n. 9 (20 marzo 2016): 936–44. http://dx.doi.org/10.1200/jco.2015.62.4767.

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Purpose We examined the prognostic and predictive value of serum human epidermal growth factor 2 (HER2) extracellular domain (sHER2) in patients with advanced breast cancer treated with lapatinib using data from three randomized trials. Patients and Methods We analyzed sHER2 and tissue HER2 (tHER2) data from 1,902 patients (84%) who were randomly assigned to receive lapatinib or control in the trials EGF30001, EGF30008, and EGF100151. Cox regression analyses were performed to correlate both biomarkers with progression-free survival (PFS) and overall survival (OS). Results Median sHER2 levels were 25.1 and 10.1 ng/mL in tHER2-amplified (tHER-positive) and nonamplified (tHER-negative) populations, respectively (r = 0.42 for sHER2-tHER2 correlation). Lapatinib had significant PFS benefit over control (hazard ratio [HR], 0.855; P = .004), but not OS (HR, 0.941; P = .33). Lapatinib PFS benefit is independently predicted by higher sHER2 values (HR per 10-ng/mL increase in sHER2: lapatinib-containing therapies, 1.009 v nonlapatinib-containing therapies, 1.044; Pinteraction < .001) and by positive tHER2 (HR [lapatinib v nonlapatinib]: tHER2 positive, 0.638 v tHER2 negative, 0.940; Pinteraction = .001). Within the tHER2-positive subpopulation (n = 515), higher sHER2 values still independently predicted lapatinib PFS benefit (HR per 10-ng/mL increase in sHER2: lapatinib-containing therapies, 1.017 v nonlapatinib-containing therapies, 1.041; Pinteraction = .008). In control arms (n = 936), higher sHER2 was associated with worse prognosis in multivariable analyses (PFS HR per 10 ng/mL: PFS, 1.024; P < .001; and OS, 1.018; P < .001). Conclusion Higher sHER2 predicts greater PFS benefit with lapatinib independent of tHER2 status. High sHER2 is also independently prognostic for worse survival in patients who received nonlapatinib-containing therapies. The predictive role of sHER2 for other anti-HER2 agents requires further research.
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Mistiaen, Wilhelm, Ivo Deblier, Karl Dossche e Anthony Vanermen. "Clinical Outcomes after Surgical Aortic Valve Replacement in 681 Octogenarians: A Single-Center Real-World Experience Comparing the Old Patients with the Very Old Patients". Geriatrics 9, n. 2 (1 aprile 2024): 44. http://dx.doi.org/10.3390/geriatrics9020044.

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Aortic valve disease is a lethal condition, once it becomes symptomatic. Surgical aortic valve replacement (SAVR) has, for a long time, been the only treatment option. In patients aged 85 and older, the consequences of SAVR have rarely been investigated. A total of 681 octogenarian patients were subdivided into a group with patients between 80 and 84 years (n = 527) and a group with patients aged 85 or older (n = 154). For each group, the temporal referral pattern, preoperative comorbid profile, operative data, postoperative need for resources, and adverse postoperative events including 30-day mortality and long-term survival were determined using the chi-squared test, Student’s t-test, and log-rank test. For both age groups, the predictors for mortality were identified using a logistic regression analysis. In the oldest patient group, there were significantly more prior episodes of heart failure (75/154 vs. 148/527) and a greater need for urgent SAVR (45/150 vs. 109/515). The operative data and the need for postoperative resources were comparable, but the 30-day mortality was almost twice as high (24/154 vs. 45/527). The need for urgent SAVR was twice as high in the oldest group (odds ratio of 3.12 vs. 6.64). A logistic regression analysis for all 681 patients showed that age over 85 ranked fourth of six predictors for 30-day mortality. Five-year survival was favorable for both groups (67.8 ± 2.1% vs. 60.0 ± 4.3%). A Cox proportional hazard analysis failed to identify an age over 85 as a predictor for long-term mortality. Aortic valve disease and its effect on the left ventricle seemed to be more advanced in the highest age group. The mortality rate was almost double the need for urgent SAVR. This can be avoided by obtaining an earlier referral.
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Kerschbaum, Saskia. "Jasmin Hettinger, Hochwasservorsorge im Römischen Reich. Praktiken und Paradigmen, Stuttgart (Franz Steiner Verlag) 2022 (Geographica Historica 44), 493 S., 21 Abb., 1 Tab., 9 Kt., ISBN 978-3-515-13266-4 (brosch.), € 84,–". Klio 105, n. 2 (1 novembre 2023): 727–31. http://dx.doi.org/10.1515/klio-2023-2018.

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37

Rudnicka-Kassem, Dorota. "Yūsuf Idrīs (1927-1991): Identitätskrise und Gesellschaftlicher Umbruch, by Birgitta Ryberg. (Beiruter Texte und Studien, Band 41) 226 pages, indices, bibliography. Beirut & Stuttgart: Franz Steiner Verlag, 1992. 84 DM (Paper) ISBN 3-515-05277-1". Middle East Studies Association Bulletin 28, n. 1 (luglio 1994): 136–37. http://dx.doi.org/10.1017/s002631840002931x.

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38

Bermúdez Lorenzo, Juan Manuel. "J. Hoffmann-Salz Die wirtschaftlichen Auswirkungen der römischen Eroberung. Vergleichende Untersuchungen der Provinzen Hispania Tarraconensis, Africa Proconsularis und Syria. (Historia Einzelschriften 218.) Pp. 561, maps. Stuttgart: Franz Steiner, 2011. Cased, €84. ISBN: 978-3-515-09847-2." Classical Review 63, n. 1 (1 marzo 2013): 299–300. http://dx.doi.org/10.1017/s0009840x12004015.

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Díaz-Mas, Paloma. "Studemund-Halévy, Michael, ed. (2016), <em>A Sefardic Pepper-Pot in the Caribbean. History, Language, Literature, and Art.</em> Colección Fuente Clara, 36. Barcelona: Tirocinio, 515 páginas. ISBN 978-84-942925-5-2". Miscelánea de Estudios Árabes y Hebraicos. Sección Hebreo 66 (9 gennaio 2018): 227–31. http://dx.doi.org/10.30827/meahhebreo.v66i0.994.

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40

Ravandi-Kashani, Farhad, Hagop Kantarjian, Stefan Faderl, Susan O’Brien, Deborah Thomas, Charles Koller, Jorge Cortes, Sherry Pierce, Michael Keating e Elihu Estey. "Long Term Follow-Up of Patients with Hairy Cell Leukemia (HCL)." Blood 104, n. 11 (16 novembre 2004): 3473. http://dx.doi.org/10.1182/blood.v104.11.3473.3473.

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Abstract (sommario):
Interferon-a (IFN-a) and, more recently, nucleoside analogs (NA) such as 2-CDA and pentostatin have been used with significant success to treat HCL. A single course of 2-CDA produces response rates over 75%, with responses maintained for 4 years in 75% of pts. Similar results have been observed with pentostatin. (Dearden et al, Br J Haematol1999;106:515). To learn more about long-term outcome, we reviewed 234 pts with untreated HCL seen at the MDACC over a 30-year period; their median follow-up was 122 months from diagnosis (up to 387 months). Their median age at diagnosis was 50 years (range 23–83 years). Survival was superior among the 173 pts given either 2-CDA (n = 161) or pentostatin (n = 12) compared to those never given either NA (p = 0.042). Figure Figure Relapse occurred in 32 of 176 pts who received 2-CDA as their first chemotherapy either at MDACC or before presenting to MDACC. Therapy for relapse after 2-CDA included rituximab (N=9), a second course of 2-CDA (n=9), a second course of 2-CDA followed by rituximab (n=8), and other (n=6). No statistically significant differences in survival were seen possibly due to small pt numbers. The estimated 10-year and 20-year survival (from diagnosis) for the 176 pts who received 2-CDA as first chemotherapy was 84%, and 65%, respectively. Figure Figure The majority of pts who died were not in remission at time of death and thus presumably died of HCL. Hence alternatives to NA are needed in at least some pts, and we are evaluating whether covariates exist that might distinguish pts who do and do not relapse and, among the former, pts whose remissions are short. Pending identification of the latter and keeping in mind the length of the average remission, alternatives to NA should have very little toxicity. We have begun to add rituximab to 2-CDA to lengthen remission duration and thus extend survival in pts with untreated HCL.
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Ausín-Olmos, Santiago. "Jaime VÁZQUEZ ALLEGUE, Los hijos de la luz y los hijos de las tinieblas. El prólogo de la Regla de la Comunidad de Qumrán, Ed. Verbo Divino, Estella 2000, 434 pp., 16 x 23,5, ISBN 84-8169-515-0." Scripta Theologica 34, n. 1 (30 novembre 2017): 407. http://dx.doi.org/10.15581/006.34.14036.

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42

Bieber, Paul, Teresa M. Seifried, Julia Burkart, Jürgen Gratzl, Anne Kasper-Giebl, David G. Schmale e Hinrich Grothe. "A Drone-Based Bioaerosol Sampling System to Monitor Ice Nucleation Particles in the Lower Atmosphere". Remote Sensing 12, n. 3 (7 febbraio 2020): 552. http://dx.doi.org/10.3390/rs12030552.

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Abstract (sommario):
Terrestrial ecosystems can influence atmospheric processes by contributing a huge variety of biological aerosols (bioaerosols) to the environment. Several types of biological particles, such as pollen grains, fungal spores, and bacteria cells, trigger freezing processes in super-cooled cloud droplets, and as such can contribute to the hydrological cycle. Even though biogenic particles are known as the most active form of ice nucleation particles (INPs), the transport to high tropospheric altitudes, as well as the occurrence in clouds, remains understudied. Thus, transport processes from the land surface into the atmosphere need to be investigated to estimate weather phenomena and climate trends. To help fill this knowledge gap, we developed a drone-based aerosol particles sampling impinger/impactor (DAPSI) system for field studies to investigate sources and near surface transport of biological INPs. DAPSI was designed to attach to commercial rotary-wing drones to collect biological particles within about 100 m of the Earth’s surface. DAPSI provides information on particulate matter concentrations (PM10 & PM2.5), temperature, relative humidity, and air pressure at about 0.5 Hz, by controlling electrical sensors with an onboard computer (Raspberry Pi 3). Two remote-operated sampling systems (impinging and impacting) were integrated into DAPSI. Laboratory tests of the impinging system showed a 96% sampling efficiency for standardized aerosol particles (2 µm polystyrene latex spheres) and 84% for an aerosol containing biological INPs (Betula pendula). A series of sampling missions (12 flights) were performed using two Phantom 4 quadcopters with DAPSI onboard at a remote sampling site near Gosau, Austria. Fluorescence microscopy of impactor foils showed a significant number of auto-fluorescent particles < 0.5 µm at an excitation of 465–495 nm and an emission of 515–555 nm. A slight increase in ice nucleation activity (onset temperature between −27 °C and −31 °C) of sampled aerosol was measured by applying freezing experiments with a microscopic cooling technique. There are a number of unique opportunities for DAPSI to be used to study the transport of bioaerosols, particularly for investigations of biological INP emissions from natural sources such as birch or pine forests.
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Hartmann, Katrin, e Jutta Hein. "Labordiagnostische Referenzbereiche bei Meerschweinchen". Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 31, n. 06 (2003): 383–89. http://dx.doi.org/10.1055/s-0037-1622380.

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ZusammenfassungDas Ziel der Arbeit war, Referenzwerte für Blutparameter bei gesunden Meerschweinchen verschiedener Rassen mit einer für die Praxis geeigneten Blutentnahmemethode zu erstellen. Zur Sammlung der Daten wurde Blut von 101 klinisch gesunden Meerschweinchen, im Alter von sechs Wochen bis fünfeinhalb Jahren, aus der V. saphena lateralis entnommen. Für die folgenden Parameter wurden Referenzbereiche bestimmt: Hämatokrit (0,39-0,55 l/l), Hämoglobinkonzentration (7,26-10,51 mmol/l), Erythrozytenzahl (4,51-6,36 × 1012/l), Erythrozytenindices (MCHC: 18,1-19,7 mmol/l; MCH: 1,50-1,70 fmol/l; MCV: 80,3-89,1 fl), Leukozytenzahl (2910-14420 × 106/l), Differenzialblutbild (Monozyten: 0-657 × 106/l [0-9%]; Lymphozyten: 1401- 10665 × 106/l [28-84%]; stabkernige neutrophile Granulozyten: 0-72 × 106/l [0-1%]; segmentkernige neutrophile Granulozyten: 889-5097 × 106/l [12-62%]; eosinophile Granulozyten: 0-1563 × 106/l [0-14%]; basophile Granulozyten: 0-106 × 106/l [0-2%]) und Thrombozytenzahl (273-745 × 109/l), die Enzymaktivitäten der Alaninaminotransferase (ALT: 0-61 IU/l), alkalischen Phosphatase (AP: 0-418 IU/l), Aspartataminotransferase (AST: 0-90 IU/l), Glutamatdehydrogenase (GLDH: 0-17 IU/l), γ-Glutamyltransferase (γ-GT: 0-13 IU/l), Laktatdehydrogenase (LDH: 0-515 IU/l), Kreatinkinase (CK: 0-2143 IU/l), α-Amylase (0-3159 IU/l), Lipase (0-152 IU/l) und Cholinesterase (CHE: 0-8052 IU/l), die Konzentration der Substrate Glukose (4,95-15,95 mmol/l), Fruktosamin (134-271 µmol/l), Gesamteiweiß (44,4-65,8 g/l) mit Auftrennung durch Elektrophorese (Albumin: 25,5- 41,1 g/l [53,0-69,7%], α1-Globulin: 1,0-3,6 g/l [2,0-6,3%]; α2-Globulin: 7,9-14,8 g/l [16,3-27,1%]; β-Globulin: 2,5-6,8 g/l [4,8-11,4%]; γ-Globulin: 1,7-7,8 g/l [3,3-13,4%]), Cholesterin (0,31-1,67 mmol/l), Triglyzeride (0,33-2,35 mmol/l), Serum- gallensäuren (0,0-84,5 µmol/l), Bilirubin (0-1,59 µmol/l), Harnstoff (3,34-10,33 mmol/l) und Kreatinin (0-77 µmol/l) sowie der Elektrolyte Kalzium (2,4-3,1 mmol/l), Phosphat (1,03-6,98 mmol/l), Magnesium (0,99-2,56 mmol/l), Natrium (130-150 mmol/l), Kalium (4,5-8,8 mmol/l), Chlorid (94-111 mmol/l) und Eisen (26-76 µmol/l). Alters- (≤ 4 Monate und > 4 Monate) und Geschlechtsabhängigkeiten (männlich/ weiblich) wurden ermittelt.
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44

Rodriguez, George D., Roman Yashayev, Bella Yushuvayev, Anna Kula, Nathan Warren, Geeti Dhillon, Demetra Tsapepas et al. "A Novel Antimicrobial Stewardship Program-Guided Procalcitonin Initiative for Emergency Department Diagnosis of Bacterial Pneumonia in New York City". Open Forum Infectious Diseases 4, suppl_1 (2017): S27—S28. http://dx.doi.org/10.1093/ofid/ofx162.068.

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Abstract Background An accurate diagnosis of bacterial pneumonia in the Emergency Department (ED) is challenging, resulting in inappropriate antibiotic use, adversely impacting patient care and safety. Procalcitonin (PCT), a serum biomarker, has good positive predictive value for bacterial lower respiratory tract infections. We sought to evaluate the impact of using PCT in an antimicrobial stewardship program (ASP)-driven algorithm to manage patients with presumed pneumonia in the ED. Methods We performed an IRB-approved quality initiative, 4-month retrospective evaluation of adult patients evaluated for pneumonia using PCT in a 515-bed university-affiliated hospital. Initial PCT use was restricted to ED for hemodynamically stable patients with presumed pneumonia. Subsequent PCT levels were ordered by ASP team members at 8- to 12-hours and days 3, 5, and 7 to guide the duration of antibiotic use and interpreted as per existing guidelines. Prior to start of initiative, aggressive education was provided by ASP to ED staff, followed by algorithm implementation. Outcomes included hospital admission, days of antibiotics, antibiotic use ≤48 hours, total PCT levels, length of stay, and 30-day pneumonia readmission. Results Baseline demographics of initial 182 patients differed between negative and positive PCT groups with age (78 vs. 84, P = 0.037) and sexfemale (88 vs. 15, P = 0.001). Negative PCT was associated with lower temperature (P = 0.0002), and white blood cell count (P = 0.0001) on admission (Figure 1). Patients with negative PCT had reduced antibiotic initiation (71% vs. 95%, P = 0.001) and were less likely to be admitted (89% vs. 98%, P = 0.078). A total of 460 PCT levels were collected [negative group: 303, median 2(2,2), positive group: 157, median 4(3,4)]. Patients with negative PCT had reduced antibiotic duration (P &lt; 0.001) and length of stay (P = 0.004) (Figures 2 and 3). There were no reported adverse events or differences in 30-day pneumonia readmissions. Conclusion Implementation of a PCT algorithm through ASP is a novel and efficacious addition to improving diagnostic yield, targeting appropriate therapy, and reducing length of stay. The impact on antibiotic resistance remains to be determined. Disclosures All authors: No reported disclosures.
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Gomes, Francisco B. "Graells i Fabregat, R. & Lorrio Alvarado, A. J., Problemas de cultura material: broches de cinturón decorados a molde de la Península Ibérica (s. VII-VI A.C.), Universitat d’Alacant, Alicante, 2017, 271 pp., ilustrado [ISBN 978-84-9717-515-9]". Conimbriga 56 (19 luglio 2018): 227–330. http://dx.doi.org/10.14195/1647-8657_56_9.

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46

Rafel, Núria. "Dirk Brandherm with Salvador Rovira Llorens. Las espadas del Bronce Final en la Península Ibérica y Baleares (Prähistorische Bronzefunde, Abteilung IV, 16. Band). xii+212 pages, 84 illustrations, tables. 2007. Stuttgart: Franz Steiner; 978-3-515-09166-4 hardback €96." Antiquity 83, n. 322 (1 dicembre 2009): 1197–98. http://dx.doi.org/10.1017/s0003598x00099567.

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47

Lienhard, Siegfried. "Dyczkowski, Mark S.G., The Cult of the Goddess Kubjikā. A Preliminary Comparative Textual and Anthropological Survey of a Secret Newar Goddess [Nepal Research Centre Publications No. 23]. Stuttgart: Franz Steiner Verlag 2001, pp. 84, 7 plates. ISBN 3-515-08106-2. €28,-." Indo-Iranian Journal 47, n. 1 (11 marzo 2004): 66–68. http://dx.doi.org/10.1163/15728536-04701011.

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Kraus, Hans-Christof. "Conrad, Benjamin: Umkämpfte Grenzen, umkämpfte Bevölkerung. Die Entstehung der Staatsgrenzen der Zweiten Polnischen Republik 1918–1923 (Quellen und Studien zur Geschichte des östlichen Europa, Bd. 84). Stuttgart: Steiner 2014. ISBN 978-3-515-10908-6. – 382 S., 9 s/w-Karten; 62,– Euro." Jahrbuch für die Geschichte Mittel- und Ostdeutschlands 64, n. 1 (10 ottobre 2019): 365–66. http://dx.doi.org/10.1515/jgod-2018-0059.

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49

Domka, Joanna, Jintae Lee e Thomas K. Wood. "YliH (BssR) and YceP (BssS) Regulate Escherichia coli K-12 Biofilm Formation by Influencing Cell Signaling". Applied and Environmental Microbiology 72, n. 4 (aprile 2006): 2449–59. http://dx.doi.org/10.1128/aem.72.4.2449-2459.2006.

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ABSTRACT We previously discovered that yliH and yceP are induced in Escherichia coli biofilms (D. Ren, L. A. Bedzyk, S. M. Thomas, R. W. Ye, and T. K. Wood, Appl. Microbiol. Biotechnol. 64:515-524, 2004). Here, it is shown that deletion of yceP (b1060) and yliH (b0836) increases biofilm formation in continuous-flow chambers with minimal glucose medium by increasing biofilm mass (240- to 290-fold), surface coverage (16- to 31-fold), and mean thickness (2,800-fold). To determine the genetic basis of the increase in biofilm formation, we examined the differential gene expression profile in biofilms for both the mutants relative to the wild-type strain in rich medium with glucose and found that 372 to 882 genes were induced and that 76 to 337 were repressed consistently >2-fold (P ≤ 0.05). The increase in biofilm formation was related to differential expression of genes related to stress response (8 to 64 genes) for both mutants, including rpoS and sdiA. More importantly, 42 to 130 genes related to autoinducer 2 cell signaling were also differentially expressed, including gadAB and flgBCEGHIJLMN, as well as signaling through indole, since 17 to 26 indole-related genes were differentially expressed, including phoAER, gltBD, mtr (encodes protein for indole import), and acrEF (encodes proteins for indole export). Increased biofilm formation in the yliH and yceP mutants in LB supplemented with 0.2% glucose (LB glu) occurred through a reduction in extracellular and intracellular indole concentrations in both mutants (50- to 140-fold), and the addition of indole to the culture restored the wild-type biofilm phenotype; hence, indole represses biofilms. Additionally, both mutants regulate biofilms through quorum sensing, since deletion of either yliH or yceP increased extracellular autoinducer 2 concentrations 50-fold when grown in complex medium (most notably in the stationary phase). Both proteins are involved in motility regulation, since YliH (127 amino acids) and YceP (84 amino acids) repressed motility two to sevenfold (P ≤ 0.05) in LB, and YceP repressed motility sevenfold (P ≤ 0.05) in LB glu. Heightened motility in the yceP mutant occurred, due to increased transcription of the flagella and motility loci, including fliC, motA, and qseB (3- to 86-fold). We propose new names for these two loci: bssR for yliH and bssS for yceP, based on the phrase “regulator of biofilm through signal secretion.”
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50

Katz, Alan J., e Josephine Kang. "Stereotactic body radiation therapy for low-, intermediate- and high-risk prostate cancer: Disease control and quality of life at 9 years." Journal of Clinical Oncology 34, n. 2_suppl (10 gennaio 2016): 20. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.20.

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20 Background: Stereotactic body radiation therapy (SBRT) takes advantage of the prostate’s low α/β ratio to deliver a large radiation dose in a few fractions. This prospective study expands upon prior studies to further evaluate SBRT efficacy and QOL for a large patient population that includes low-, intermediate- and high-risk patients with prostate cancer. Methods: 515 patients with organ-confined prostate cancer (471 T1c and 44 T2a, all N0M0) received robotic SBRT. The median age was 69 years and the median PSA was 6.48 ng/ml. By NCCN criteria, 324 patients were low-risk, 139 were intermediate-risk, and 52 were high-risk. Androgen deprivation therapy was administered to 70 patients for up to one year. 158 patients with Gleason scores < 4+3 received 35 Gy delivered in 5 daily fractions. The remaining patients, from all risk groups, received a total dose of 36.25 Gy in 5 daily fractions. The proximal seminal vesicles were treated except in low-risk cases. Biochemical failure was assessed using the Phoenix criterion and QOL was assessed with EPIC scoring. Results: At a median follow-up of 84 months, 74 patients died (72 from unrelated causes). The median PSA at 78 months was 0.11 ng/ml. The actuarial 9 year freedom from biochemical failure was 95%, 89%, and 66% for the low-, intermediate- and high-risk groups (p = 0.01). For patients with Gleason scores < 4+3, there was no difference in terms of median nadir or biochemical control between doses of 35 and 36.25 Gy. Late RTOG toxicity was mild with 4% grade 2 rectal, 9.5% grade 2 urinary, and 1.9% grade 3 urinary. Late grade 2-3 urinary toxicity was 6.9% for 35 Gy vs. 13.2% for 36.25 Gy (p = 0.01). Mean EPIC urinary and bowel QOL declined at 1 month post-treatment and returned to baseline by 2 years where it remains. EPIC sexual QOL declined by 29% at 78 months. Conclusions: SBRT alone produces excellent biochemical control rates at up to 9 years with mild toxicity and minimal impact on quality of life. These long-term results appear superior to standard IMRT with lower cost and are strikingly similar to HDR therapy. These results also strongly suggest that 35 Gy is as effective as 36.25 Gy for patients with Gleason < 4+3, with less urinary toxicity.
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