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1
Soni, Arpita, Anil Kumar, Abhishek Kumar, Ravindra Sachan, Anupama Verma e Ram Ashish. "Impact of Industrial Effluent on Physico-Chemical Properties of Soil in Unnao District of Uttar Pradesh, India". International Journal of Plant & Soil Science 35, n. 20 (11 ottobre 2023): 1300–1305. http://dx.doi.org/10.9734/ijpss/2023/v35i203930.
Testo completoAbstract (sommario):
A study was carried out during 2021-22 considering various vegetable growing farmers in Unnao District (U.P.) to find out the effect of using industrial effluents as the only source of irrigation to their crops. 250 surface soil samples collected from farmer’s field were analyzed for physical as well as chemical parameters. The physical properties of soils improved due to industrial effluent irrigation. Among the physical properties bulk density ranged from 1.15 to 1.55 Mg m-3 and particle density ranged between 2.61 to 2.86 Mg m-3. Chemical Parameters of soil such as pH , EC, OC, Available N, P &K were also analyzed and the results indicated that soils had a mean pH of 8.1, E.C. of 1.25 dSm-1, O.C. of 0.756 %, available nitrogen ranged from 377 – 1035 kg ha-1 with mean of 658.26 kg ha-1.The Phosphorus availability was found ranging from 20.5 – 48.80 kg ha-1 with a mean of 35.97 kg ha-1, while Potassium was found with a mean of 204.12 kg ha-1 in range of 163 – 302.2 kg ha-1.
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Abuelgassim, Abuelgassim Omer, Mohamed Abdellatif Eltayeb e Farid Shokry Ataya. "Palm date (Phoenix dactylifera) seeds: A rich source of antioxidant and antibacterial activities". Czech Journal of Food Sciences 38, No. 3 (29 giugno 2020): 171–78. http://dx.doi.org/10.17221/269/2019-cjfs.
Testo completoAbstract (sommario):
Two varieties of palm date seeds (PDS), Sukkari and Khalas, were examined for their antioxidant and antibacterial activities. Total phenol content was 2 014.37 ± 212.05 and 2 060.40 ± 176.0 mg GAE 100 g–1 dry weight (DW); and total flavonoid content was 83.98 ± 1.10 and 94.97 ± 1.36 mg QE 100 g–1 DW for Sukkari and Khalas, respectively. PDS extracts showed potential scavenging activity against ABTS, DDPH, and hydroxyl radical; the calculated IC50s were 431.17 ± 12.45, 400 ± 10.87 and 680 ± 18.12 µg for Sukkari, and 476 ± 20.25, 302.24 ± 14.08 and 284.18 ± 11.62 µg for Khalas, respectively. PDS extracts did not show potential activity against superoxide anion. Both extracts showed a high percentage of reducing power as the calculated FRAP (ferric reducing antioxidant power) concentrations were 12.66 ± 1.08 and 16.14 ± 1.94 mmol ascorbic acid equivalent 100 g–1 for Sukkari and Khalas, respectively. Bacillus subtilis showed a remarkable sensitivity to PDS extracts; the inhibition zones were 21 ± 0.82 and 22 ± 0.67 mm for Sukkari and Khalas, respectively. PDS extracts possess good antioxidant and antibacterial activity, and therefore PDS could be effectively used as a natural source of antioxidants and to be detected against gram-positive bacteria.
3
Khan, Hajera, Swapna S. Bandewar, Mohammad Zameeruddin e Vishvanath B. Bharkad. "Spectroscopic Determination of Aspirin and Omeprazole by Absorbance Ratio and Multicomponent Mode Method". International Journal of Pharmaceutical Sciences and Nanotechnology 10, n. 6 (30 novembre 2017): 3900–3905. http://dx.doi.org/10.37285/ijpsn.2017.10.6.4.
Testo completoAbstract (sommario):
Here we describe a simple, rapid and accurate method for simultaneous assay of aspirin and omeprazole. The first method was Absorbance ratio method (Method 1) and second method was multi component mode method of analysis (Method 2). Methanol: water (8:2) was used as solvent for both methods, using 293 nm as isobestic point for absorbance ratio method. The wavelength ranges 275.80 nm for aspirin and 302.20 nm for omeprazole for method 2, which represents the absorbance maxima of both drugs respectively. Beer’s law was applied in the concentration ranges of 2-14μg/mL and 2-18 μg/mL for aspirin and omeprazole, respectively, in absorbance ratio methods. The percentage assay was found to be in the range 99.74 to 100 % for aspirin and 99.69 to 99.9 % for omeprazole for both the methods. Recovery was found in the range of 99.74 –100.14 % for aspirin and omeprazole for both methods. The analysis data has been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed methods, which were carried out according to the ICH guidelines.
4
Li, Xiaodong. "Preparation and Adsorption Properties of Biochar/g-C3N4 Composites for Methylene Blue in Aqueous Solution". Journal of Nanomaterials 2019 (10 giugno 2019): 1–8. http://dx.doi.org/10.1155/2019/2394184.
Testo completoAbstract (sommario):
Using straw and urea as raw materials, biochar (BC) and g-C3N4 were prepared by oxygen-free pyrolysis at 300°C and 550°C. BC/g-C3N4 was prepared by loading different amounts of g-C3N4 onto the surface of biochar and characterized by SEM and FT-IR. The adsorption effect on methylene blue (MB) was investigated from the aspects of dosage and pH. The studies of adsorption equilibrium isotherms and the kinetic and the thermodynamic parameters on the BC/g-C3N4 adsorbents are discussed. The results showed that BC/g-C3N4 0.16 g/L with a doping ratio of 1 : 3 was added to the MB solution with an initial concentration of 50 mg/L and pH=11. The adsorption rate and adsorption amount were 96.72% and 302.25 mg/g, respectively. The adsorption process included surface adsorption and intraparticle diffusion, which conformed to the pseudo-second-order kinetic model and Langmuir-Freundlich model. Thermodynamic parameters (ΔG0<0, ΔH0>0, and ΔS0>0) showed that the adsorption reaction is spontaneous, which positively correlated with temperature.
5
Maure, Gerson Hans, Emerensiana Latuan e Mariam Alota. "INCOME AND FEASIBILITY ANALYSIS OF COFFEE FARMING". JURNAL AGRIBISAINS 9, n. 2 (2 ottobre 2023): 1–8. http://dx.doi.org/10.30997/jagi.v9i2.7753.
Testo completoAbstract (sommario):
The coffee plant is a national leading commodity in the plantation sub-sector. Alor Regency as an area with a dry climate, has great potential for the development of coffee plants in East Nusa Tenggara Province. The total area of coffee plantations in 2022 in this area will reach 2118 ha with a bean production of 302.2 tons/year. The research was carried out in Maleipea Village, Alor Selatan District from March to May 2022. The sample was determined using the Slovin formula. The processed data comes from direct interviews with farmers and through publications from the Central Bureau of Statistics and the Food and Agriculture Office of Alor Regency. This study aims to analyze the community's income and the feasibility of coffee farming in Malaipea Village. The characteristics of the respondents observed in this study were age, gender, education level, length of business, and land area. The results showed that the income of coffee farming in Malaipea Village was Rp. 1,658,324 with an R/C value of ˃ 1, which is 17.79, so coffee farming in Maleipea Village is feasible.
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Nsengiyumva, J., K. N. Taremwa, H. Vasanthakaalam, P. Musabyimana, V. Ruganzu e N. Etim. "Hydrochemical characteristics and suitability of Kanzenze River for irrigation of akagera upper catchment in Rwanda". Agro-Science 21, n. 4 (6 settembre 2023): 1–12. http://dx.doi.org/10.4314/as.v21i4.1.
Testo completoAbstract (sommario):
The purpose of the study was to assess the hydrochemical characteristics of the Kanzenze River and its suitability for irrigation use in the Akagera upper catchment in Rwanda. In this respect, 12 samples of surface collected water in four sites namely Karumuna, Muzi, Karugenge, and Nyamabuye were at a distance of 100.00 meters one to another. The Food and Agriculture Organization (FAO) standards were referred to analyze water quality parameters such as potential hydrogen (pH), electrical conductivity (EC), total dissolved solids (TDS), sodium adsorption ratio, soluble sodium percent, total hardness, magnesium adsorption ratio and Kelly index were used for the evaluation of water quality and its suitability for irrigation. Data were analyzed using descriptive analysis and principal components analysis. All parameters analyzed were within the FAO standards stipulated for irrigation. The mean pH of the water sample was 7.30; the mean TDS was 205.10 mg l‒1; mean sodium adsorption was 2.30 while the mean EC was 302.26 µS/cm which indicated that Kanzenze River is in category I of classification standard suitable for irrigation. This indicated that the Kanzenze River was suitable for irrigation.
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Rebecca, Rebecca, e Siufui Hendrawan. "Kapasitas Total Antioksidan dan Uji Toksisitas Ekstrak Daun Binahong (Anredera cordifolia (Ten.) Steenis)". Bioscientist : Jurnal Ilmiah Biologi 11, n. 1 (30 giugno 2023): 889. http://dx.doi.org/10.33394/bioscientist.v11i1.9202.
Testo completoAbstract (sommario):
Oxidative stress is an imbalance between the production of Reactive Oxygen Species (ROS) and antioxidants in the body. One plant that contains antioxidants is binahong leaves (Anredera cordifolia (Ten.) Steenis). To determine the compound content contained in binahong leaves, a total antioxidant capacity test and toxicity test were carried out on binahong leaves. This research used an in-vitro experimental study consisting of an antioxidant capacity test with DPPH (1.1-diphenyl-1-picrylhydrazil) and a bioassay, namely a toxicity test with the Brine Shrimp Lethality Test (BSLT) from binahong leaf extract. Extraction of binahong leaves is carried out using the maceration method using methanol solvent and then evaporated to obtain the extract. The total antioxidant capacity test was carried out using the Blois method, the Brine Shrimp Lethality Test (BSLT) toxicity test using the Meyer method. In the antioxidant capacity test, the IC50 value was 284.199 μg/mL, which means that the antioxidant capacity of binahong leaf extract is relatively low. In the toxicity test, the LC50 was obtained at 302.25 μg/mL, which means that binahong leaf extract has a level of toxicity against (Artemia salina L.) shrimp larvae. So it can be concluded that binahong leaf extract has relatively low antioxidant capacity and has toxic properties which are thought to have antimitotic properties.
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Jagtap, Kartikey, Anuradha Mulik, E. A. Singh e Suresh Jagtap. "Comparative Study to Evaluate Ethanol and Ethyl Acetate Extracts of Different 'Vidanga' Species for Antioxidant Efficacy and Phyto-Constituents Screening". Biomedical and Pharmacology Journal 15, n. 1 (31 marzo 2022): 165–77. http://dx.doi.org/10.13005/bpj/2352.
Testo completoAbstract (sommario):
In Ayurveda, ‘Vidanga’ is one such species high in demand for its various uses. All the species of genus Embelia and Maesa belonging to the family Myrsinaceae are reported as ‘Vidanga’. Considering the availability of plant material in the market there is an ambiguity in supplying the authentic species as ‘Vidanga’. In the present study, a comparative analysis was carried out to determine the efficacy of different 'Vidanga’ spp. in terms of their phyto-constituents, antioxidant potential, and free radical scavenging activity. The highest total phenolic contents (TPCs) and total flavonoid contents (TFCs) were found to be in ethanolic and ethyl acetate extract. Quantitative measurements also showed that abundance of phenolic and flavonoid phytoconstituents was significantly (P<0.001) greater in ethanolic extract of all the ‘Vidanga’ fractions (1.773±0.01 to 137.17±0.19 mg/g GAE and 4.84±0.001 to 302.29±0.07 mg/g of quercetin respectively) than in ethyl acetate extract (1.15±0.003 to 15.12±0.01 mg/g GAE and 7.94±0.05 to 25.20±0.001 mg/g of quercetin respectively). Ethanolic extract of Embelia ribes had significant activity in terms of IC50 than ethyl acetate extracts in the case of 2,2-diphenyl,1- picryl hydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and anti-lipid peroxidation (ALP) (9.53, 9.73 and 6.21 µg/mL respectively) indicates Embelia ribes found to be most effective species as ‘Vidanga’. Pearson’s correlation (r2) analysis also suggests a significant correlation between different antioxidant parameters and bioactive constituents. This study may helpful to draw attention of researchers to characterize the various bioactive compounds from the Embelia ribes in terms of their antioxidant prospective.
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Akhabue, E. F., U. D. Chima e F. S. Eguakun. "Comparative evaluation of growth performance and soil quality of two age sequences of Gmelina arborea plantation in University of Port Harcourt, Nigeria". Journal of Applied Sciences and Environmental Management 24, n. 10 (3 novembre 2020): 1767–73. http://dx.doi.org/10.4314/jasem.v24i10.9.
Testo completoAbstract (sommario):
This study was conducted in 2019 to compare the growth performance and soil quality of two agesequences of Gmelina arborea plantation within the premises of the University of Port Harcourt, Nigeria. Data were collected from two stands of G. arborea established in 2011 and 2015. Growth performance was evaluated based on tree growth variables and above-ground carbon stored. Tree growth variables estimated were total height (TH), diameter at breast height (DBH), crown height (CH), crown diameter (CD) and merchantable height (MH). Topsoil (0 – 30 cm) samples collected from the two sites were analyzed for particle size distribution, organic carbon (OC), total nitrogen (TN), available phosphorus (Av.P), exchangeable bases (Mg, Ca, K and Na), exchangeable acidity (Al+ H+), effective cation exchange capacity (ECEC), base saturation (BS), pH, Manganese (Mn), Iron (Fe), Copper (Cu) and Zinc (Zn). The above-ground biomass (AGB) and carbon stock (CS) were also determined. T-test was used to test for significant difference in the measured parameters between the two age-sequences of G. arborea. Higher values for TH, DBH, CS and MH were recorded for the older stand although the differences between the two age-sequences were not significantly different (p ≥ 0.05). The AGB and CS per hectare were higher for the older than the younger G. arborea stand (302.27 m3 ha-1 and 151.52 m3 ha-1, respectively). Higher values for silt, clay, Ca, Mg, Al+ H+, ECEC, BS, Mn, Fe and Zn were also recorded for the older stand. However, the observed differences were only significant (p < 0.05) for clay, pH, Av.P, Mn and Fe. The study revealed that although soil properties, tree growth as well as carbon sequestration capacity of G. arborea stand improved/increased with age, the differences were mainly not statistically significant (p ≥ 0.05) between the two (eight and four years) age-sequences.
Keywords: Gmelina arborea, age sequence, soil quality, carbon sequestration
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Idris, Lini, Muhammad Amirul Adli, Nurul Najihah Yaacop e Rozaini Mohd Zohdi. "Phytochemical Screening and Antioxidant Activities of Geniotrigona thoracica Propolis Extracts Derived from Different Locations in Malaysia". Malaysian Journal of Fundamental and Applied Sciences 19, n. 6 (4 dicembre 2023): 1023–32. http://dx.doi.org/10.11113/mjfas.v19n6.3128.
Testo completoAbstract (sommario):
Propolis, a natural resinous substance secreted by bees, has garnered considerable interest due to its diverse bioactive compounds and potential health benefits. Nevertheless, the phytochemical composition of propolis exhibits significant variation, influenced by multiple factors including geographical region, and botanical origin. These determinants exert profound effects on the distinctive properties and biological diversities of propolis. This study aimed to investigate the phytochemical composition and antioxidant activities of Geniotrigona thoracica propolis extracts collected from three apiary sites, designated as apiary A, apiary B, and apiary C, located in different regions within Selangor. The ethanolic extracts of propolis were prepared using 70% of ethanol and subjected to phytochemical screening to identify the presence of flavonoids, terpenoids, alkaloids, saponins, tannins, steroids, and cardiac glycosides, whilst the total phenolic content (TPC) and total flavonoid content (TFC) were measured using the Folin-Ciocalteu colorimetric and aluminium chloride methods, respectively. Additionally, the antioxidant activities of the propolis extracts were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric-reducing antioxidant power (FRAP) assays. The phytochemical screening revealed the presence of flavonoids, terpenoids, alkaloids, saponins, tannins, steroids, and cardiac glycosides in all propolis extracts. The propolis from apiary A exhibited significantly higher TPC (302.21 ± 0.11 mg/mL GAE) and TFC values (99.08 ± 0.03 mg/mL QE) compared to apiary B and C. The results also indicated that propolis from apiary A possessed significantly higher antioxidant activities, with IC₅₀ value of DPPH at 25.27 μg/mL and FRAP value of 727.53 ± 0.09 μM Fe²+, in comparison to apiary B and C. A strong correlation was observed between TPC, TFC, and IC₅₀ of DPPH. This study highlights significant variations in the phytochemical compositions and antioxidant activities of propolis samples collected from different geographical and botanical sources. Further investigation is in progress to identify the specific phytochemical constituents responsible for these variations.
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Nurrachmi, Irvina, Bintal Amin, Dilla Andini, M. Afriansyah e Rifqi Rafif Anadri. "THE DISTRIBUTION AND ABUNDANCE OF TOXIC BENTHIC DINOFLAGELLATES IN MALANG RAPAT COASTAL WATERS OF BINTAN ISLAND, KEPULAUAN RIAU". Asian Journal of Aquatic Sciences 6, n. 1 (10 aprile 2023): 108–14. http://dx.doi.org/10.31258/ajoas.6.1.108-114.
Testo completoAbstract (sommario):
This research was conducted in May - June 2018 by surveying and taking a sample from Malang Rapat water on the East Coast of Bintan Island, Kepulauan Riau to determine the abundance and distribution of toxic benthic dinoflagellates associated with seaweed (Sargassum sp) and seagrass (Enhalus accoroides). Samples were taken from four sampling locations which were carried out purposively by taking into account the different anthropogenic activities that occurred in each region. The results of the study found 3 genera of toxic benthic dinoflagellates, namely Gambierdiscus sp, Ostreopsis sp, and Prorocentrum sp. The highest abundance of toxic benthic dinoflagellates associated with Sargassum sp was found in station 3, which was 302.279 cells/g, and the lowest at station 4 with (133.529 cells/g), while E. accoroides has the highest abundance at station 1 which was 620.65 cells/g). The abundance of toxic dinoflagellates in Sargassum sp has a positive correlation with nitrate concentration, but on the contrary, it was negatively correlated with the concentration of nitrate and phosphate in these waters to E. accoroides. The measured water quality parameters were still within the tolerance range for the marine organism. Further research is still needed to answer the cause of these differences and whether there are any fluctuations of abundance and the specific appearance of the toxic dinoflagellate.
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Ayonga, Erick O., Diana M. Ondieki e Erick K. Ronoh. "Effects of different pretreatments on thin-layer drying kinetics, vitamin A retention and rehydration of orange-fleshed sweet potato slices". Journal of Agriculture, Science and Technology 22, n. 6 (23 gennaio 2024): 20–37. http://dx.doi.org/10.4314/jagst.v22i6.2.
Testo completoAbstract (sommario):
Orange-fleshed sweet potato (OFSP) is a bio-fortified sweet potato with a high beta-carotene content. OFSP deteriorates rapidly due to its high moisture content. Conventional air drying is one of the most common methods employed but has the disadvantage of low rates of moisture removal, hence the longer drying time, which affects the quality of the final product. Pretreatments prevent quality deterioration and hasten the drying rate. This study investigated the effects of different pretreatments on thin-layer drying kinetics and the quality of OFSP slices. Three-mm-thick OFSP slices were pretreated using three different pretreatments: lemon juice, salt solution, and hot water blanching (HWB). Pretreated slices were dried in a solar dryer. Data collection (weight, temperature, relative humidity, and solar radiation) was done at 1-hour intervals. Four mathematical models (Page, Logarithmic, Modified Page, and Henderson and Pabis) were fitted to the experimental data. Also, the quality parameters of vitamin A and rehydration were investigated. The dryer inside temperatures and relative humidity ranged from 26.93–44.53 oC and 36.87%–65.30%, respectively. The moisture content of fresh OFSP slices for both treated and untreated samples was found to be in the range of 291.55–302.24% (dry basis, db), which reduced to 25.25–35.25% (db) after drying. The drying time ranged between 11 and 13 hours. The page model was found to be the best model for untreated samples, with R2 of 0.9948, RMSE of 0.0151, and χ2 of 0.0097, while the logarithmic model best described the drying behaviour of all the pretreated samples because it had the highest values of R2 and the lowest values of RMSE and χ2. Lemon juice-pretreated samples had the best quality parameters (vitamin A retention and rehydration ratio). A maximum rehydration ratio of 1.6765 was obtained for samples pretreated with lemon juice, and a minimum rehydration ratio of 1.1390 was obtained from HWB-pretreted samples. The results, therefore, indicate that lemon juice can be used as a pretreatment for thin-layer drying of OFSP slices. Pretreatments help minimise postharvest losses associated with OFSP, thus contributing to solving food and nutrition insecurity challenges.
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Леонтієв, Б. С., e О. П. Хворост. "Study of the elemental composition of a series of virland fruits Viburnum Opulus L." Farmatsevtychnyi zhurnal, n. 5 (27 ottobre 2023): 62–70. http://dx.doi.org/10.32352/0367-3057.5.23.07.
Testo completoAbstract (sommario):
Viburnum fruits are a well-known and popular means of folk and scientific medicine. It is used as a vitamin, immunostimulating, diuretic, hypotensive agent. There is information about the use of viburnum fruit processing products in the food industry. Today, there is no drug based on this raw material in our country. A systematic study of the composition of the mineral compounds of viburnum fruits from different harvesting locations in Ukraine was not conducted. This is especially relevant because the significant content of organic acids to a certain extent determines the presence of a number of cations.
The purpose of the work is to determine the elemental composition of the series of common domestic medicinal plant raw materials – Viburnum fruits, harvested in Ukraine.
In the results of the research conducted by the method of atomic absorption spectrography with photographic registration of the results, it was found that in total at least 19 macro-, micro- and ultra-microelements were found in the raw materials. The content of total ash in series of viburnum fruits was determined. It ranged from 0.120 ± 0.005% (series 1) to 0.326 ± 0.010% (series 6). The following regularity is observed for the accumulation of macroelements in raw materials: for all studied series of raw materials, potassium and calcium dominated in terms of content (K > Ca). Significant data variability is observed for the remaining macronutrients. So, for the fruits of series 1 and 5, the following variant is defined – P > Mg > Na > Si, series 2 – Mg > Na > P, Si, series 3 – Mg > Na, P > Si, series 4 – Mg > P > Si > Na, series 6 – Na > Mg > P > Si.
The results of the study show that the potassium content ranges from 986.28 ± 9.27 mg/100 g (series 5) to one and a half times higher – 1451.38 ± 15.34 mg/100 g (series 5). In addition to potassium, the studied series contain large amounts of calcium – its content fluctuates more than twice, in the range: 302.29 ± 3.20 mg/100 g (series 2) – 661.30 ± 3.14 mg/100 g ( series 4). In addition to potassium and calcium, a fairly high content of magnesium was found – its content ranges from 79.22 ± 0.96 mg/100 g (series 5) to 107.95 ± 1.27 mg/100 g (series 6).
The highest content of phosphorus was determined in viburnum fruits of ordinary series 1 – 125.56 ± 1.59 mg/100 g, in the rest of the raw materials this indicator is 1.3–8 times lower, the lowest in fruits of series 2 – 15.80 ± 0,30 mg/100 g. The highest sodium content was determined in the raw materials of series 6 – 144.81 ± 1.84 mg/100 g. At that time, Viburnum fruits of series 2 contained almost five times less of this element (30.92 ± 0.61 mg/100 g). The fruits of series 6 are the leader in the accumulation of silicon compared to the rest of the studied series (where the content of this element can be five times lower) and contain 74.01 ± 0.87 mg/100 g of this compound.
A significant content of potassium (at least 980 mg/100 g), calcium (at least 300 mg/100 g), and magnesium (at least 75 mg/100 g), which play an important role in the functioning of the human body, confirms the perspective of taking into account the elemental of the pharmaceutical composition in the creation of original medicinal products.
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Setyawan, Nurdi, e Widaningrum Widaningrum. "PENGARUH SUHU PENGGORENGAN VAKUM DAN CARA PEMBUMBUAN TERHADAP KARAKTERISTIK KERIPIK WORTEL (Effect of vacuum frying temperature and various technique of flavoring on characteristics of carrot chips)". Jurnal Penelitian Pascapanen Pertanian 10, n. 2 (18 gennaio 2017): 104. http://dx.doi.org/10.21082/jpasca.v10n2.2013.104-112.
Testo completoAbstract (sommario):
<p>Sayuran merupakan bahan pangan yang mudah rusak. Penanganan pascapanen yang baik penting untuk menekan kerusakan, menjaga kualitas nutrisi dan keamanan sayuran. Perubahan gaya hidup konsumen yang menginginkan segala sesuatu yang serba cepat menuntut tersedianya bahan pangan siap santap (dalam bentuk snack) yang dapat langsung dikonsumsi. Teknologi pengolahan sayuran segar menjadi produk sayuran kering siap santap merupakan salah satu alternatifnya. Teknologi penggorengan dengan tekanan rendah memungkinkan mengolah komoditi sayuran menjadi hasil olahan berupa keripik (chip). Tujuan penelitian ini adalah untuk mengetahui pengaruh suhu penggorengan vakum dan cara pembumbuan terhadap karakteristik keripik wortel siap santap. Perlakuan yang diterapkan adalah (1) pembumbuan (basah dan kering) dan (2) suhu penggorengan (60-70oC, 70-80oC, dan 80-90oC). Rancangan penelitian adalah rancangan acak lengkap dengan 4 kali ulangan. Hasil penelitian menunjukkan bahwa kombinasi perlakuan pembumbuan basah dan suhu penggorengan vakum (60-70)°C menghasilkan produk keripik wortel yang paling baik dengan kadar protein (7,37 %), kadar FFA (0,47 %), vitamin A (302,25 ppm), dan kadar serat (8,77%). Hasil analisis organoleptik, produk keripik wortel dengan perlakuan pembumbuan basah dan suhu penggorengan vakum (60-70)°C paling disukai oleh panelis.</p><p>Kata kunci :suhu, penggorengan vakum, bumbu, keripik wortel</p><p>English Version Abstract</p><p>Vegetables are perishable foodstuffs. Postharvest handling is essential to reduce damage, maintain safety and nutritional quality of vegetables. Changing in consumer lifestyles who want everything fast-paced demands the availability of food ready to eat (snacks) that can be eaten. Technology for processing fresh vegetable into dried vegetables products that ready to eat is one of the alternatives. Frying Technology with low pressure allows the processing of commodities into processed vegetables in the form of crisps (chips). The objective of the research was to determine the effect of vacuum frying temperature and technique of flavoring on the characteristics of carrots ready to eat. The treatments applied were (1) technique of flavoring (wet and dry) and (2) frying temperature (60-70°C, 70-80°C, and 80-90°C). The research used factorial completely randomized design with four replications. The results showed that combined treatment wet flavoring method and vacuum frying temperature (60-70)°C produced the best dried carrots with protein (7.37 %), FFA (0.47 %), vitamin A (302.248 ppm), and crude fiber (8.77 %). The results of organoleptic test showed that dried carrot products with wet flavoring method and vacuum frying temperature (60-70)°C most preferred by the panelists.</p><p>Keywords : Temperature, vacuum frying, flavoring, carrot chips</p>
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Doty, Raymond T., Marilyn Sanchez-Bonilla, Siobán B. Keel e Janis L. Abkowitz. "FLVCR1a But Not FLVCR1b Is Required For Effective Erythropoiesis In Adult Mice". Blood 122, n. 21 (15 novembre 2013): 308. http://dx.doi.org/10.1182/blood.v122.21.308.308.
Testo completoAbstract (sommario):
Abstract There are two characterized isoforms of FLVCR. The long form, FLVCR1a, is a broadly expressed cell surface heme exporter (Cell 118: 757, 2004) which exports heme from the cytoplasm to an extracellular carrier protein (JBC 285: 28874, 2010). The short isoform, FLVCR1b, is transcribed off an internal promoter and localizes to the mitochondria where it exports heme out of mitochondria into the cytoplasm (JCI 112: 4569, 2012). Adult mice with an induced deletion of both isoforms of FLVCR develop severe macrocytic anemia (Science 319: 825, 2008), indicating that FLVCR is essential for erythropoiesis. Mice constitutively lacking both isoforms of FLVCR die midgestation with craniofacial and digit abnormalities and lack definitive erythropoiesis while mice lacking only FLVCR1a die midgestation with craniofacial and digit abnormalities yet appear to have intact erythropoiesis (Science 319: 825, 2008, JCI 112: 4569, 2012). These results suggest that FLVCR1b, and not FLVCR1a, is required for erythropoiesis. To definitively test whether FLVCR1a or FLVCR1b is sufficient for red cell development, we transplanted mice with marrow lacking both isoforms of FLVCR that had been transduced with either FLVCR1a or FLVCR1b along with a GFP marker. Both cohorts of mice had comparable marking frequency in granulocytes (31.1±16.4%, N=15, FLVCR1a vs 32.7±16.9%, N=8, FLVCR1b) at 4 weeks post-transplant. By 7 wks post-transplant, 71.3±19.7% of the RBC in mice that received FLVCR1a were derived from transduced cells, while only 1.0±0.8% of the RBC in mice that received FLVCR1b were derived from transduced cells. Mice that received FLVCR1a are healthy and have normal CBC parameters (WBC 8.34±4.7 k/ml, RBC 7.95±1.2 M/ml, HGB 12.5±1.7 g/dl, MCV 47.9±2.0 fl , PLT 879±387 k/ml) which persist 9 months later, while mice that received FLVCR1b are severely anemic (WBC 1.9±1.3 k/ml, RBC 1.5±0.6 M/ml, HGB 2.0±0.8 g/dl, MCV 36.5±0.8 fl , PLT 1442±1232 k/ml) and die by 8 weeks post-transplant. This demonstrates that only the FLVCR1a isoform is capable of reconstituting erythropoiesis in adult mice lacking both isoforms in hematopoietic cells. One possible way to reconcile these data with the reported role of FLVCR1b, would be if FLVCR1b were needed during fetal, but not adult, erythropoiesis. As mentioned above, adult mice with an induced deletion of FLVCR develop severe macrocytic anemia (HBG 6.5±2.2 g/dl, MCV 67.9±7.3 fL; vs controls 14.6±0.7, 44.7±3.6), in contrast, over expression of FLVCR1a results in mild hypochromic microcytic anemia (HBG 13.2±1.4 g/dl, MCV 41±5.2 fL; vs controls 15.4±0.5, 49.3±1.3). Because hypochromasia and microcytosis only result from heme or hemoglobin deficiency, FLVCR1a must export heme from differentiating erythroblasts in vivo. To confirm this, we sorted developing erythroblasts from FLVCR-deleted and control mice and measured heme content at each stage. Terminally differentiating erythroid precursors (populations I-IV, PNAS 106: 17413, 2009) from FLVCR-deficient mice have significantly more heme than those from control mice (I&II 359.6±99.9 pg/cell, III 702.2±302.2 pg/cell, IV 657.8±292.9 pg/cell, versus controls 131.4±65.2, 153.9±27.1, and 269.1±102.7 respectively, all p<0.05) and have significantly more apoptosis. To definitively demonstrate that heme toxicity causes proerythroblast apoptosis and macrocytic anemia, we are using existing mouse model systems to modulate impact heme synthesis or degradation and test whether they alter the effect of FLVCR deletion on erythropoiesis. The presence of the ferrochelatase mutation, Fechm1Pas/m1Pas, does not rescue FLVCR deficiency, most likely because the accumulation of toxic precursor products which are also substrates of FLVCR (JBC 285: 28874, 2010). We are currently evaluating whether over-expression of HO-1 or restricted expression of the transferrin receptor can mitigate the effect of FLVCR deletion. Disclosures: No relevant conflicts of interest to declare.
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Sarker, Md Al-Amin, Saleha Jasmine e Mst Sultanan Okela. "Effects of Feeding Frequency on Growth Performance and Production of Labeo rohita (Hamilton, 1822) Reared in Cage". Asian Journal of Fisheries and Aquatic Research, 28 gennaio 2021, 23–33. http://dx.doi.org/10.9734/ajfar/2021/v11i130194.
Testo completoAbstract (sommario):
Optimum feeding schedule is one of the main things for the proper growth of fish and other animals. A study was conducted to optimize the effects of different feeding frequencies on growth performance and production of Rui (Labeo rohita) under pond cage culture system in Rajshahi, Bangladesh. Labeo rohita with an average weight of 302.23±4.07g (mean ± SD) were randomly stocked in 9 cages at 30 fish/cage in all the treatment. Fish were fed (4% of body weight) a commercial floating feed with three different feeding schedules: feeding of fish thrice daily in T1treatment; twice in T2 treatment and once in T3 treatment. Water quality parameters were measured during the study period. The physico-chemical parameters of pond water were within suitable ranges for fish culture in cages. The obtained values of the water quality parameters were temperature 28.26 to 28.46°C, pH 6.91 to 6.94, DO 5.04 to 5.33 mg/l, CO2 2.95 to 3.02 mg/L. The mean final weight gain was significantly highest in T1 (345.05 g) a followed by T2 (324.66 g) and T3 (257.82 g). The Specific growth rate (SGR) value were significantly higher in T1 treatment (0.91% bwd-1; Body weight per day) than T2 (0.87% bwd-1) and T3 treatment (0.73% bwd-1). The feed conversion ratio (FCR) value was significantly lower in T1 fish group (2.72) than other two T2 (2.84) and T3 (3.44) treatments. The fish productions were 18.13, 17.55 and 15.67 kg/cage/cycle in T1, T2 and T3 respectively. The highest net profit was found (Bangladeshi Taka, BDT 1445.38) in T1 compared to T2 (BDT 1329.24) and T3 treatment (BDT 937.99). The cost benefit ratio (CBR) was significantly higher in T1 (0.57) than T2 (0.53) and T3 (0.37). The feeding schedule three times in a day was most suitable than other two schedules.
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Junaid Iqbal, Muhammad. "CONSTITUTIVE MATERIAL MODEL FOR BLOCK MASONRY AND ITS MECHANICAL PROPERTIES". JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES 16, n. 4 (24 aprile 2021). http://dx.doi.org/10.26782/jmcms.2021.04.00005.
Testo completoAbstract (sommario):
This research work aims at the development of a material model for concrete block masonry used in the load-bearing wall as well as masonry infill. To accomplish this, various tests were performed on concrete block (solid) units and concrete block masonry assemblage. A concrete block having a size of 12 x 8 x 6 inches, were fabricated in a mortar ratio of 1:4, 1:2:2, 1:8 and 1:4:4. The compressive strength of concrete block prisms having size 24.36 x 8.04 x 18.72 inches, was also determined by conducting the compressive strength test. The shear strength of square prisms, having size 26.76 x 8.04 x 25.20 inches, was found by applying diagonal loading. To investigate the bond shear strength of concrete block masonry, triplet tests were carried out on block masonry prisms. Before conduct, a test on block assemblage specimens, the constituent materials of block assemblage i.e. block and mortar were also tested for different properties. The average compressive strength of concrete block (12”x8”x6”) was 302.25 psi and the average unit weight was 119.83 lb/ft3. The compressive strength of mortars of 1:4, 1:2:2, 1:8 and 1:4:4 was 2367, 1752,815 and 1332 psi respectively.
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JEON, So-Heon, Hyo-Seung CHOI e Soon-Ho Yim. "Establishment of simultaneous analysis validation for Perilla frutescens var. acuta extract". Food Science and Technology 43 (1 dicembre 2023). http://dx.doi.org/10.5327/fst.00018.
Testo completoAbstract (sommario):
In this study, the UV spectra maximum absorption wavelengths and molecular weights of major compounds 1–3 were identified in Perilla frutescens var. acuta extract using high-performance liquid chromatography (HPLC)-DAD and HPLC-MS/MS. Luteolin-7-O-diglucuronide (1), scutellarin (2), and rosmarinic acid (3) were identified, and simultaneous analysis validation was performed for quantification using HPLC-DAD. All linearities showed R2 values of 0.9993 or higher, and the limits of detection and quantification were measured in the ranges of 4.4802–5.4133 and 13.5764–16.4038 µg/mL, respectively. The relative standard deviation (RSD) values for accuracy ranged from 0.09 to 0.89%, and the recovery rates were in the range of 99.36–101.96%. The precision RSD values within the laboratory were in the range of 0.05–1.04%, and the RSD values for repeatability evaluation were below the guideline criteria of 2%. The content change of the three marker compounds within 24 h was 0.36–0.69%, confirming the chemical stability of the extract within 24 h, which was below the guideline criteria of 2.0% established by the Ministry of Food and Drug Safety guidelines. The content analysis of the extract according to ethanol concentration showed that luteolin-7-O-diglucuronide had the highest content of 302.22 µg/mL in the 0% ethanol extract, while scutellarin and rosmarinic acid showed the highest contents of 103.61 and 118.77 µg/mL, respectively, in the 60% ethanol extract.
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Xia, Baoyun, Benjamin C. Blount, Tonya Guillot, Christina Brosius, Yao Li, Dana M. Van Bemmel, Heather L. Kimmel et al. "Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)". Nicotine & Tobacco Research, 27 luglio 2020. http://dx.doi.org/10.1093/ntr/ntaa110.
Testo completoAbstract (sommario):
Abstract Introduction The tobacco-specific nitrosamines (TSNAs) are an important group of carcinogens found in tobacco and tobacco smoke. To describe and characterize the levels of TSNAs in the Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014), we present four biomarkers of TSNA exposure: N′-nitrosonornicotine, N′-nitrosoanabasine, N′-nitrosoanatabine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which is the primary urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Methods We measured total TSNAs in 11 522 adults who provided urine using automated solid-phase extraction coupled to isotope dilution liquid chromatography–tandem mass spectrometry. After exclusions in this current analysis, we selected 11 004 NNAL results, 10 753 N′-nitrosonornicotine results, 10 919 N′-nitrosoanatabine results, and 10 996 N′-nitrosoanabasine results for data analysis. Geometric means and correlations were calculated using SAS and SUDAAN. Results TSNA concentrations were associated with choice of tobacco product and frequency of use. Among established, every day, exclusive tobacco product users, the geometric mean urinary NNAL concentration was highest for smokeless tobacco users (993.3; 95% confidence interval [CI: 839.2, 1147.3] ng/g creatinine), followed by all types of combustible tobacco product users (285.4; 95% CI: [267.9, 303.0] ng/g creatinine), poly tobacco users (278.6; 95% CI: [254.9, 302.2] ng/g creatinine), and e-cigarette product users (6.3; 95% CI: [4.7, 7.9] ng/g creatinine). TSNA concentrations were higher in every day users than in intermittent users for all the tobacco product groups. Among single product users, exposure to TSNAs differed by sex, age, race/ethnicity, and education. Urinary TSNAs and nicotine metabolite biomarkers were also highly correlated. Conclusions We have provided PATH Study estimates of TSNA exposure among US adult users of a variety of tobacco products. These data can inform future tobacco product and human exposure evaluations and related regulatory activities.
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Shirao, Satoshi, Hiroshi Yoneda, Hideyuki Ishihara, Hiroko Yoshino, Kazutaka Sugimoto, Hiroyasu Koizumi, Eiichi Suehiro et al. "Abstract WP437: The Relationship Between Cholesterol And Cerebral Vasospasm In A Rat Model Of Subarachnoid Hemorrhage: A Mechanistic Role For Lipid Rafts". Stroke 44, suppl_1 (febbraio 2013). http://dx.doi.org/10.1161/str.44.suppl_1.awp437.
Testo completoAbstract (sommario):
Objective: Rho-kinase (ROK)-mediated vascular smooth muscle (VSM) contraction plays a pivotal role in cerebral vasospasm (CV). Sphingosylphosphorylcholine (SPC), a sphingolipid, induces ROK-mediated VSM contraction, and hypercholesterolemia increases SPC-ROK-mediated VSM contraction. Lipid rafts are cholesterol-enriched membrane microdomains that influence signal transduction. In this study, we report the effect of cholesterol and lipid rafts on CV. Methods: Adult male Sprague-Dawley rats (400-500g, n=53) were fed control, 1% cholesterol or 1% cholesterol +5% β-cyclodextrin (β-CD), which depletes VSM cholesterol, diets for 8 weeks. We used a double-hemorrhage rat subarachnoid hemorrhage (SAH) model, and investigated CV of the basilar artery (BA) at Day5 using a cranial window. T-Cho levels in the internal carotid artery (ICA) were measured using Gas Chromatography. The expression of Flotillin-1, a raft marker, and Flotillin-1 mRNA in the ICA were analysed by Western blot and real-time RT-PCR, respectively. Results: The BA diameters were 358.94±32.05μm and 302.21±38.36μm in control diet (non-treated) and SAH rats, respectively (n=9/group, p<0.05 vs. non-treated). SAH-induced BA contraction was markedly reversed by intracisternal infusion of 10μM Y27632 (n=4, p<0.05), a ROK inhibitor. The BA diameter in SAH rats fed the cholesterol diet was 248.11±34.56μm (n=6, p<0.05 vs. control SAH-rats), compared with 305±25.28μm in SAH rats fed a β-CD diet (n=6, p<0.05 vs. SAH-rat fed a cholesterol diet). T-Cho levels in the ICA were significantly higher in rats fed a cholesterol diet compared with the control diet (0.82±0.24 vs. 0.49±0.09mg/g, n=5/group, p=0.028) or the β-CD diet (0.47±0.06 mg/g, n=5, p=0.016 vs. cholesterol diet). Western blot analysis and real-time RT-PCR revealed increases in Flotillin-1 and Flotillin-1 mRNA expression in the ICA from rats fed a cholesterol diet, whereas Flotillin-1 and Flotillin-1 mRNA expression were not altered in the ICA from rats fed the β-CD diet. Conclusions: These results indicate that cholesterol potentiates SAH-induced CV and are compatible with a role for lipid rafts in this process.
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Huo, Jia, Sikai Liu, Mengnan Li, Zeming Liu, Xuzhuang Ding, Bo Liu, Huijie Li e Yongtai Han. "Femoral neck fracture patients with ischaemic stroke choose hemiarthroplasty or constrained liner total hip arthroplasty? A retrospective comparative study of 199 cases". Frontiers in Surgery 10 (16 ottobre 2023). http://dx.doi.org/10.3389/fsurg.2023.1258675.
Testo completoAbstract (sommario):
BackgroundThe objective of this study was to assess the long-term survival rate, complications, as well as the clinical and radiological outcomes of hemiarthroplasty and total hip arthroplasty using constrained polyethylene liners in patients with ischemic stroke.MethodsThis study was a retrospective cohort study that included patients with ischemic stroke who underwent hip arthroplasty from March 2010 to September 2017. In the Constrained Acetabular Liners (CAL) group, patients received an uncemented acetabular shell with a constrained polyethylene liner. The Dual Mobility (DM) group underwent hemiarthroplasty (HA). Additionally, hip function, range of motion, quality of life, the incidence of clinical complications, and prosthesis stability were investigated.Results96 patients with unilateral femoral neck fractures who underwent hip replacement with CAL were included in the CAL group, while 103 patients who underwent hip replacement with a dual mobility head were included in the DM group. VAS, and SF-36 data were available for both CAL and DM groups. At the 1-year postoperative follow-up, the HHS in the CAL group was significantly lower than that in the DM group (80.83 ± 3.91 vs. 83.17 ± 4.15, P < 0.05). The VAS score in the CAL group peaked at the 1-year follow-up (2.07 ± 0.91 vs. 1.49 ± 0.85, P < 0.05). However, there were no significant differences between the two groups in terms of HSS, VAS, and SF-36 at the last follow-up after surgery. Operative time and the amount of bleeding in the DM group were significantly lower than those in the CAL group (105.30 ± 29.68 vs. 94.85 ± 31.07; 355.11 ± 123.95 vs. 302.22 ± 107.68, P < 0.05). Additionally, there was no significant difference in the mean leg length discrepancy between the two groups.ConclusionThe clinical, imaging, and postoperative complications of the CAL and DM groups were analyzed. The prognosis for DM appears to be more beneficial for early patient recovery, but a higher likelihood of recurrent dislocation is observed. CAL offers excellent stability for primary THA in high-risk patients; however, attention should be given to preventing aseptic loosening.
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Wang, Jing, Jie Zeng, Chao Zhang, Wenwen Zheng, Xilu Huang, Nan Zhao, Guangyou Duan e Cong Yu. "Optimized ventilation strategy for surgery on patients with obesity from the perspective of lung protection: A network meta-analysis". Frontiers in Immunology 13 (18 ottobre 2022). http://dx.doi.org/10.3389/fimmu.2022.1032783.
Testo completoAbstract (sommario):
ObjectivesNew ventilation modes have been proposed to support the perioperative treatment of patients with obesity, but there is a lack of consensus regarding the optimal strategy. Therefore, a network meta-analysis update of 13 ventilation strategies was conducted to determine the optimal mode of mechanical ventilation as a protective ventilation strategy decreases pulmonary atelectasis caused by inflammation.MethodsThe following databases were searched: MEDLINE; Cochrane Library; Embase; CINAHL; Google Scholar; and Web of Science for randomized controlled trials of mechanical ventilation in patients with obesity published up to May 1, 2022.ResultsVolume-controlled ventilation with individualized positive end-expiratory pressure and a recruitment maneuver (VCV+PEEPind+RM) was found to be the most effective strategy for improving ratio of the arterial O2 partial pressure to the inspiratory O2 concentration (PaO2/FiO2), and superior to pressure-controlled ventilation (PCV), volume-controlled ventilation (VCV), volume-controlled ventilation with recruitment maneuver (VCV+RM), volume-controlled ventilation with low positive end-expiratory pressure (VCV+lowPEEP), volume-controlled ventilation with lower positive expiratory end pressure (PEEP) and recruitment maneuver (VCV+lowPEEP+RM), and the mean difference [MD], the 95% confidence intervals [CIs] and [quality of evidence] were: 162.19 [32.94, 291.45] [very low]; 180.74 [59.22, 302.27] [low]; 171.07 [40.60, 301.54] [very low]; 135.14 [36.10, 234.18] [low]; and 139.21 [27.08, 251.34] [very low]. Surface under the cumulative ranking curve (SUCRA) value showed VCV+PEEPind+RM was the best strategy for improving PaO2/FiO2 (SUCRA: 0.963). VCV with high positive PEEP and recruitment maneuver (VCV+highPEEP+RM) was more effective in decreasing postoperative pulmonary atelectasis than the VCV+lowPEEP+RM strategy. It was found that volume-controlled ventilation with high positive expiratory end pressure (VCV+highPEEP), risk ratio [RR] [95% CIs] and [quality of evidence], 0.56 [0.38, 0.81] [moderate], 0.56 [0.34, 0.92] [moderate]. SUCRA value ranked VCV+highPEEP+RM the best strategy for improving postoperative pulmonary atelectasis intervention (SUCRA: 0.933). It should be noted that the quality of evidence was in all cases very low or only moderate.ConclusionsThis research suggests that VCV+PEEPind+RM is the optimal ventilation strategy for patients with obesity and is more effective in increasing PaO2/FiO2, improving lung compliance, and among the five ventilation strategies for postoperative atelectasis, VCV+highPEEP+RM had the greatest potential to reduce atelectasis caused by inflammation.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021288941.
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Shutov, Evgeny, Galina Kotlyarova, Ksenia Lysenko, Galina Ryabinskaya e Sergey Lashutin. "MO793COMPARATIVE STUDY BETWEEN THE IMPACT OF ETELCALCETIDE AND CINACALCET ON LEVELS OF IPTH, FGF-23, KLOTHO PROTEIN, SCLEROSTIN, CA AND P IN DIALYSIS PATIENTS WITH SECONDARY HYPERPARATHYROIDISM. RESULTS FROM A PROSPECTIVE RANDOMIZED TRIAL". Nephrology Dialysis Transplantation 36, Supplement_1 (1 maggio 2021). http://dx.doi.org/10.1093/ndt/gfab096.002.
Testo completoAbstract (sommario):
Abstract Background and Aims The treatment of secondary hyperparathyroidism is one of the main tasks in the correction of mineral and bone disorders (MBD) in patients with chronic kidney disease (CKD). However, the results of therapy for secondary hyperparathyroidism are still unsatisfactory. In our prospective randomized controlled trial were evaluated the effect and safety of 26 weeks of treatment with etelcalcetide (intravenous route of administration) compare with cinacalcet (oral administration) on CKD-MBD parameters in patients on program hemodialysis with secondary hyperparathyroidism. Method The study group included 50 stable patients receiving hemodialysis with secondary hyperparathyroidism (PTH > 300 pg/ml) and corrected Ca level greater than 2.2 mmol/L, who were randomized in a 1: 1 ratio for treatment with etelcalcetide (n = 25) or cinacalcet (n = 25) for 26 weeks. All patients were monthly evaluated the levels of P, Ca, intact parathyroid hormone (iPTH), alkaline phosphatase (ALP); the levels of FGF 23, Klotho protein and sclerostin were assessed once in 3 months. The dose of both drugs was adjusted according to the serum iPTH level. The nature, frequency, and severity of treatment-emergent adverse events were assessed. Results Therapy with cinacalcet and etelcalcetide led to a significant decrease in the level of iPTH in the blood serum from 613.1 ± 235.1 to 302.2 ± 205.1pg/ml (p< 0.01) and from 671.2 ± 272.3 to 358,6 ± 292.5 pg/ml (p <0.01), by 49.2% and 53.4%, respectively. A significant decrease in the levels of corrected Ca was noted in both groups: in the etelcalcetide group from 2.20 ± 0.12 to 2.06 ± 0.18 mmol/L (p <0.05), in the cinacalcet group from 2.25 ± 0.12 to 2.04 ± 0.21 mmol/l (p <0.05). There was no significant change in the P levels. The alkaline phosphatase level significantly decreased in the cinacalcet group from 178.7 ± 116.8 to 78.9 ± 34.1 U/L, p <0.05) and in the etelcalcetide group from 170,3 ± 115.7 to 87.1 ± 30.8 U/L, p <0.05. There was a significant increase in Klotho protein levels by the end of the study from 17.9 ± 5.0 to 57.1 ± 39.3 (p <0.05) and from 17.6 ± 3.7 to 91.6 ± 56.2 pg/ml (p <0.05), respectively, in the cinacalcet and etelcalcetide group. Changes in FGF-23 and sclerostin by 6 months reached statistically significant changes only in the etelcalcetide group, a decrease from the FGF-23 level from 42.7 ± 22.2 to 23.0 ± 12.3 pg/ml and an increase in the level of sclerostin from 1, 59 ± 0.31 to 2.20 ± 0.33 ng/ml (p <0.05). During the study, 2 patients in the cinacalcet group dropped out due to dyspeptic symptoms and 1 patient in the etelcalcetide group dropped out due to hypocalcemia. Conclusion Etelcalcetide and cinacalcet are effective PTH-lowering drugs with a comparable safety profile. Treatment with etelcalcetide, in contrast to cinacalcet, was associated with significant increases in sclerostin and decreases in FGF-23, which may have beneficial effects on outcomes and requires further study.