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Autore: Grafiati

Pubblicato: 25 luglio 2024

Ultima modifica: 31 luglio 2024

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1

Nasr, I., M. Austin e M. Tarzi. "PTU-158 Coeliac disease investigation and follow-up: Abstract PTU-158 Table 1". Gut 61, Suppl 2 (28 maggio 2012): A250.1—A250. http://dx.doi.org/10.1136/gutjnl-2012-302514c.158.

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2

Clapper, Brenda, Anh-Hue T. Tu, Warren L. Simmons e Kevin Dybvig. "Bacteriophage MAV1 Is Not Associated with Virulence of Mycoplasma arthritidis". Infection and Immunity 72, n. 12 (dicembre 2004): 7322–25. http://dx.doi.org/10.1128/iai.72.12.7322-7325.2004.

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ABSTRACT Previous studies demonstrated that Mycoplasma arthritidis strain 158 acquired a high degree of virulence upon lysogenization with bacteriophage MAV1. In the present study, the association between MAV1 and virulence was reexamined by creating new lysogens of 158 and of a relatively avirulent mutant, strain 158-1. In the absence of lysogenization, 158 was more virulent than expected. The virulence of 158 and 158-1 did not increase upon lysogenization. A major antigenic difference between 158 and 158-1 was identified that is unrelated to MAV1 and could account for the difference in virulence.

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3

Clark, John R. "Pope's Epilogue to the Satires, dialogue 1, 155–158". Explicator 50, n. 3 (aprile 1992): 144–46. http://dx.doi.org/10.1080/00144940.1992.9937936.

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4

BOYLE, K., M. ANDERSON e P. TURKELLAUB. "158 Characterization of cat extracts: Beyond fel d 1". Journal of Allergy and Clinical Immunology 87, n. 1 (gennaio 1991): 178. http://dx.doi.org/10.1016/0091-6749(91)91441-u.

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5

Zhang, Chunfen, Katie L. Zobeck e Zachary F. Burton. "Human RNA Polymerase II Elongation in Slow Motion: Role of the TFIIF RAP74 α1 Helix in Nucleoside Triphosphate-Driven Translocation". Molecular and Cellular Biology 25, n. 9 (1 maggio 2005): 3583–95. http://dx.doi.org/10.1128/mcb.25.9.3583-3595.2005.

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ABSTRACT The role of the RAP74 α1 helix of transcription factor IIF (TFIIF) in stimulating elongation by human RNA polymerase II (RNAP II) was examined using millisecond-phase transient-state kinetics. RAP74 deletion mutants RAP74(1-227), which includes an intact α1 helix, and RAP74(1-158), in which the α1 helix is deleted, were compared. Analysis of TFIIF RAP74-RAP30 complexes carrying the RAP74(1-158) deletion reveals the role of the α1 helix because this mutant has indistinguishable activity compared to TFIIF 74(W164A), which carries a critical point mutation in α1. We report adequate two-bond kinetic simulations for the reaction in the presence of TFIIF 74(1-227) + TFIIS and TFIIF 74(1-158) + TFIIS. TFIIF 74(1-158) is defective because it fails to promote forward translocation. Deletion of the RAP74 α1 helix results in increased occupancy of the backtracking, cleavage, and restart pathways at a stall position, indicating reverse translocation of the elongation complex. During elongation, TFIIF 74(1-158) fails to support detectable nucleoside triphosphate (NTP)-driven translocation from a stall position and is notably defective in supporting bond completion (NTP-driven translocation coupled to pyrophosphate release) during the processive transition between bonds.

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6

Editor, El. "Presentación No. 158". Realidad, revista de ciencias sociales y humanidades, n. 158 (22 novembre 2021): 1–2. http://dx.doi.org/10.51378/realidad.v0i158.6428.

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7

Argiles, Guillem, Christiane Jungels, Rocio Garcia-Carbonero, Marc Diez Garcia, Johanna C. Bendell, Josep Tabernero, Mohamed Bekradda et al. "Phase I dose-escalation study of MCLA-158, a first-in-class bispecific antibody targeting EGFR and LGR5, in metastatic colorectal cancer (CRC)." Journal of Clinical Oncology 39, n. 3_suppl (20 gennaio 2021): 62. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.62.

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62 Background: The WNT and EGFR signaling pathways are oncogenic and mitogenic drivers in CRC and other cancers. MCLA-158 is an ADCC enhanced human IgG1 cLC bispecific antibody identified from functional screening of CRC patient (pt)-derived organoids (PDO). MCLA-158 exposure leads to EGFR degradation in LGR5+ cancer and exhibits potent growth inhibition of RASmut and wt CRC PDOs, while minimal inhibition is observed in non-tumoral PDOs. Blockade of metastasis initiation was seen in preclinical in vivo models. MCLA-158 also demonstrated tumor regression or stasis in esophageal squamous (6/6) and gastric adenocarcinoma (6/8) PDX models selected for LGR5 and EGFR expression. Methods: Metastatic CRC pts progressing after oxaliplatin, irinotecan and fluoropyrimidines, and EGFR monoclonal antibodies if RASwt, received MCLA-158 IV every 2 weeks (q2w; 4-week cycle) in a phase I study. Safety, efficacy (per RECIST 1.1), PK and ADA were assessed. WNT and EGFR pathway components were evaluated in tumor tissue. EGFR pathway mutations (ctDNA) and soluble EGFR (sEGFR) were assessed in blood. PDOs were derived from baseline biopsies and assessed for MCLA-158 responsiveness. Results: As of 7 September 2020, 33 pts were treated over 11 dose levels (5 to 1500 mg, flat dose). At enrollment, median age was 58 years (range 35-76), ECOG PS 0/1:22/11, and 15 pts were RASmut. Pts had a median of 3 metastatic sites (range 1-12) with a median of 4 prior lines of therapy (range 1-10). A median of 2 MCLA-158 cycles (range 1-6) were administered. No dose limiting toxicity occurred. Infusion-related reactions were the most common AEs (67% of pts), occurred mostly in cycle 1 (21/22 pts), and were manageable. Other common related AEs included rash acneiform (36%), diarrhea (15%), pyrexia (9%) and asthenia/fatigue (9%). Related AEs were mostly mild or moderate; G3 related AEs were IRRs (4 pts; 12%), diarrhea and hypophosphatemia (1 pt each). The RP2D (1500 mg) was selected based on safety, PK and receptor occupancy prediction. MCLA-158 exhibited target-mediated clearance with proportional PK from 750 mg (t1/2 ~80 h at 1500 mg). Low ADA titers were seen in 3/23 pts, with no effect on PK. Target saturation is predicted at steady state serum trough levels. No clinical responses were observed during dose escalation. No/low baseline tumor EGFR expression (0-1+ IHC) was observed in 17/30 pts and non-elevated sEGFR levels ( < 4 ng/mL) in 18/22 pts. More than 1 activating mutation in EGFR signaling pathway genes were identified in ctDNA from 10/20 pts. 1/4 PDOs had > 30% growth inhibition with MCLA-158 ex vivo. MCLA-158 activity on PDOs correlated negatively with the presence of EGFR pathway resistance-mutations. Conclusions: Dual EGFR/LRG5 blockade with MCLA-158 was well tolerated, and the RP2D was 1500 mg IV q2w. Enrollment of pts with gastric and other non-CRC cancers at the RP2D continues in the expansion phase. Clinical trial information: NCT03526835.

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8

Tu, A. H. T., B. Clapper, T. R. Schoeb, A. Elgavish, J. Zhang, L. Liu, H. Yu e K. Dybvig. "Association of a Major Protein Antigen of Mycoplasma arthritidis with Virulence". Infection and Immunity 73, n. 1 (gennaio 2005): 245–49. http://dx.doi.org/10.1128/iai.73.1.245-249.2005.

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ABSTRACT Mycoplasma arthritidis causes acute polyarthritis in rats and chronic proliferative arthritis in mice. M. arthritidis-induced arthritis serves as a model for arthritis caused by infectious agents and as a model for examining the role of the superantigen MAM (M. arthritidis T-cell mitogen) in the development of autoimmunity. M. arthritidis strain 158-1 is a spontaneous mutant of strain 158 that has a drastic reduction in virulence. We show that the mutant is missing a major antigen of 47 kDa (P47) and has acquired a protein of 67 kDa (P67). P47 and P67 partitioned into the detergent phase by extraction with Triton X-114. Coomassie blue staining of sodium dodecyl sulfate-polyacrylamide gels show that P67 is produced in abundance. Analysis of gel-purified P67 by mass spectrometry led to its identification as a lipoprotein (the open reading frame [ORF] 619 gene product) predicted from the genome sequence of M. arthritidis. PCR analysis of genomic DNA from 158 and 158-1 indicates that P47 and P67 are encoded by the same ORF 619 gene and differ only in the number of repeats in a tandem repeat region. By two-dimensional polyacrylamide gel analysis, no protein differences were detectable between 158 and 158-1 other than P47 and P67. Collectively, the data suggest that the tandem repeat region of P47 and P67 influences disease outcome.

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Ebner, Karl, Simone B. Sartori, Rita Murau, Fabian Kopel, Predrag Kalaba, Vladimir Dragačević, Johann J. Leban, Nicolas Singewald, Mario Engelmann e Gert Lubec. "The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice". Biomolecules 12, n. 4 (27 marzo 2022): 506. http://dx.doi.org/10.3390/biom12040506.

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Previous studies have shown that atypical dopamine-transporter-inhibitors such as modafinil and its analogues modify behavioral and cognitive functions in rodents. Here, we tested potential promnestic effects of the novel, more dopamine-transporter selective modafinil analogue CE-158 in the social discrimination memory task in male mice. Systemic administration of CE-158 1 h before the social learning event prevented the impairment of social-recognition memory following retroactive interference 3 h after the learning session of a juvenile conspecific. This effect was dose-dependent, as mice treated with 10 mg/kg, but not with 1 mg/kg CE-158, were able to discriminate between the novel and familiar conspecific despite the presentation of an interference stimulus, both 3 h and 6 h post learning. However, when 10 mg/kg of the drug was administered after learning, CE-158 failed to prevent social memory from interference. Paralleling these behavioral effects, the systemic administration of 10 mg/kg CE-158 caused a rapid and sustained elevation of extracellular dopamine in the nucleus accumbens, a brain area where dopaminergic signaling plays a key role in learning and memory function, of freely moving mice, while 1 mg/kg was not sufficient for altering dopamine levels. Taken together, our findings suggest promnestic effects of the novel dopamine-transporter-inhibitor CE-158 in a social recognition memory test that may be in part mediated via increased dopamine-neurotransmission in the nucleus accumbens. Thus, selective-dopamine-transporter-inhibitors such as CE-158 may represent interesting drug candidates for the treatment of memory complaints observed in humans with cognitive impairments and dementia.

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Yoon, Jung-Hoon, Mi-Hwa Lee e Tae-Kwang Oh. "Porphyrobacter donghaensis sp. nov., isolated from sea water of the East Sea in Korea". International Journal of Systematic and Evolutionary Microbiology 54, n. 6 (1 novembre 2004): 2231–35. http://dx.doi.org/10.1099/ijs.0.63226-0.

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Two Gram-negative, motile, non-spore-forming, bacteriochlorophyll a-containing slightly halophilic strains, SW-132T and SW-158, were isolated from sea water of the East Sea in Korea, and subjected to a polyphasic taxonomic study. The two isolates were characterized chemotaxonomically as having Q-10 as the predominant respiratory lipoquinone and major amounts of unsaturated fatty acids C18 : 1 ω7c and C17 : 1 ω6c. The DNA G+C contents of the two strains were in the range 66·8–65·9 mol%. The 16S rRNA gene sequences of strains SW-132T and SW-158 were 99·9 % (1 nt difference) similar and their mean level of DNA–DNA relatedness was 86 %. The 16S rRNA gene sequence analysis showed that strains SW-132T and SW-158 are phylogenetically closely related to Porphyrobacter species and Erythromicrobium ramosum. Similarities between the 16S rRNA gene sequences of strains SW-132T and SW-158 and the type strains of Porphyrobacter species and E. ramosum ranged from 97·8 to 99·0 %. DNA–DNA relatedness data indicated that strains SW-132T and SW-158 are members of a genomic species that is separate from the four Porphyrobacter species. On the basis of phenotypic and phylogenetic data and genetic distinctiveness, strains SW-132T (=KCTC 12229T=DSM 16220T) and SW-158 (=KCTC 12230) are classified as a novel Porphyrobacter species, for which the name Porphyrobacter donghaensis sp. nov. is proposed.

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Hatjiharissi, Evdoxia, Mark Hansen, Sigitas Verselis, Daniel Ditzel Santos, Lian Xu, Robert Manning, Zachary Hunter et al. "Polymorphisms in FcγRIIIA Are Genetically Linked to FcγRIIA and May Account for the Primary Predictive Role Ascribed to Polymorphisms in FcγRIIIA-158 in Determining Rituximab Responses." Blood 106, n. 11 (16 novembre 2005): 2433. http://dx.doi.org/10.1182/blood.v106.11.2433.2433.

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Abstract γWe and others have previously described polymorphisms in codon 158 and 48 for FcγRIIIα as predictors of clinical responses to the anti-CD20 monoclonal antibody rituximab in patients with low-grade non-Hodgkin’s lymphoma, including Waldenström’s Macroglobulinemia. The expression of at least one valine (V) at FcγRIIIα-158 and Leucine/Histidine (L/H) at FcγRIIIα-48 is associated with higher response rates to rituximab, though primacy for FcγRIIIα-158 over 48 polymorphisms for determining rituximab response is attributed to genetic linkage. As part of these studies, we sought to determine if polymorphisms in FCγRIIA were linked to FCγRIIIA since higher response rates have been observed in patients who express Histidine/Histidine (H/H) in FcγRIIA-131. We therefore performed sequence analysis of the whole FcγRIIa gene and exons 3 and 4 of the FcγRIIIa gene in 52 healthy donors. The genetic association between polymorphisms was calculated using the statistical program GOLD and expressed as linkage disequilibrium (D’). Single nucleotide polymorphisms were commonly found in FcγRIIIa at codons 158, 48 and in FcγRIIa at codons 131, 27. The genotype frequencies for polymorphisms are as follows: FcγRIIIa-158: 25% F/F; 63% F/V; 12% V/V; FcγRIIIa-48: 67% L/L; 10% L/R; 17% L/H; FcγRIIa-131: 29% H/H; 46% H/R; 25% R/R; FcγRIIa-27: 71% Q/Q; 27% Q/W; 2% W/W. Strong linkage was found between the FcγRIIIa-158 and −48 (D’=1, p=0.001), as well as between FcγRIIa-131 and -27 (D’=1, p=0.00082). Specifically, the expression of F at FcγRIIIa-158 was found to be associated with expression of L at FcγRIIIa-48, whereas the expression of H at FcγRIIa-131 was associated with the expression of Q at FcγRIIa-27. Importantly, we observed links among polymorphisms at FcγRIIa and FcγRIIIa. Specifically, FcγRIIIa-48 was linked to FcγRIIa-27 (D’=0.765, p<0.00001) and FcγRIIa-131 (D’=1, p=0.0049), since all donors who were FcγRIIIa-48 L/L donors were also FcγRIIa-27Q/Q and -131R/R, respectively. Lastly, we also observed linkage between FcγRIIIa-158 and FcγRIIa-27 (D’=1, p=0.0008). Our results demonstrate significant genetic association between polymorphisms in FcγRIIa and FcγRIIIa genes, and may account for the primary predictive role ascribed to polymorphisms in FcγRIIIa-158 in determining rituximab responses.

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Bhattacharjee, S., CPJ Caygill, PAC Gatenby e A. Watson. "PTU-158 The Influence of Social Class on Progression of Barrett’s Oesophagus to Oesophageal Adenocarcinoma: Abstract PTU-158 Table 1". Gut 65, Suppl 1 (giugno 2016): A135.1—A135. http://dx.doi.org/10.1136/gutjnl-2016-312388.243.

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13

Chen, Xinchun, e Jinjin Li. "Corrigendum to “Superlubricity of carbon nanostructures” [Carbon 158 (2020) 1–23]". Carbon 161 (maggio 2020): 341. http://dx.doi.org/10.1016/j.carbon.2020.01.043.

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14

Escolano Pueyo, A., H. Navarro, C. Perez, B. Sebastian, M. Seral e M. Abad. "CP-158 Our experience with fampridine in patients with multiple sclerosis after 2 years of treatment: Abstract CP-158 Table 1". European Journal of Hospital Pharmacy 22, Suppl 1 (marzo 2015): A63.2—A64. http://dx.doi.org/10.1136/ejhpharm-2015-000639.151.

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Elmaagacli, Ahmet H., Hellmut Ottinger, Koldehoff Michael, Peceny Rudolf, Nina K. Steckel, Rudolf Trenschel, Harald Biersack, Hans Grosse-Wilde, Michael Flasshove e Dietrich W. Beelen. "Reduced Risk of Residual Molecular and Hematological Relapse in Patients with Cml after KIRir-Ligand Mismatched Hematpoietic Stem Cell Transplantation." Blood 104, n. 11 (16 novembre 2004): 974. http://dx.doi.org/10.1182/blood.v104.11.974.974.

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Abstract We compared the incidence of molecular and hematological relapse in 236 CML patients (pts) after HLA-identical (n=158) [group 1], HLA class I antigen mismatched and KIR-ligand compatible (n=49) [group 2], and HLA class I antigen mismatched and KIR-ligand incompatible (n=29) [group 3] hematopoietic stem cell transplantation. In group 1 133/158 (84%) pts were in first chronic phase of CML, the corresponding figures were 33/49 (67%) pts in group 2, and 19/29 (64%) in group 3 (p<0.05). Accordingly, 25/158 (16%) pts in group 1, 16/49 (33%) pts in group 2, and 10/29 (34%) pts in group 3 were in advanced disease phases of CML (accelerated phase, 2nd chronic phase, or blastic phase). Stem cell grafts were from sibling donors in 97% of pts in group 1, 37% of pts in group 2, and in 59% of pts in group 3 (p<0.01 group 1 versus groups 2+3). Median age and gender constellations were not different between the three groups (age medians between 37–41 years, range 16–63). Acute GVHD grade 2–4 occurred in 62/158 (39%) pts in group 1, in 24/49 (49%) pts in group 2, and in 15/29 (52%) pts in group 3 (NS). Estimates of chronic GVHD did not differ significantly between the study groups with 94% + 2% in group 1, 95% + 4% in group 2, and 91% ± 6% in group 3. Molecular relapse as detected by real-time RT-PCR occurred in 1/29 (3%) pts of group 3 compared to 62/158 (39%) of pts in group 1, and in 11/49 (22%) pts in group 2 (p<0.001). A hematological relapse developed in 20/158 (13%) pts in group 1, in 2/49 (4%) pts in group 2 and in 0/29 (0%) pts in group 3 (p<0.05). Multivariate analysis on the risk molecular relapse included possible influencial covariates like disease stage, age (> 40 years or < 40 years), gender matching of donor and recipient, occurrence of acute and chronic GVHD, HLA matching between donor and recipient, donor source [sibling or unrelated], and graft type [bone marrow or PBSCs]. This analysis confirmed that KIR-mismatches are a strong independent predictor for the occurrence of bcr-abl transcripts after transplantation (p<0.02). The 8-year overall survival estimates were not different between the three groups (67% group 1, 52% group 2 66% group 3). In conclusion, KIR-ligand incompatibility is an important prognostic factor for the occurrence of molecular and hematological relapse after allogeneic transplantation for CML.

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McMullan, R. K., T. F. Koetzle e C. J. Fritchie. "Low-Temperature Neutron Diffraction Study of the Silver Perchlorate–Benzene π Complex". Acta Crystallographica Section B Structural Science 53, n. 4 (1 agosto 1997): 645–53. http://dx.doi.org/10.1107/s0108768197000712.

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The crystal structure of the AgClO4.C6H6 \pi complex, earlier determined by X-ray diffraction at room temperature, has been redetermined at 18, 78 and 158 K by neutron diffraction. Crystal data: orthorhombic, space group Cmcm, Z = 4, F(000) = 225.318 fm, T: 18, 17, 158 K; D x = 2.591 (2), 2.570 (1), 2.523 (1) g cm−1; \mu n = 0.166, 0.165, 0.162 cm−1; a = 7.913 (1), 7.973 (1), 8.100 (1), 8.336 (1) Å (at 295 K); b = 7.837 (2), 7.857 (1), 7.902 (1), 7.996 (1) Å (at 295 K); c = 11.798 (3), 11.777 (2), 11.739 (2), 11.638 (2) Å (at 295 K); wR(F 2) = 0.037, 0.035, 0.045, S = 1.18, 1.08, 1.10 for 782, 628, 800 reflections and 51 variable parameters. This study confirms the principal features reported in the X-ray investigation and reveals details of structure not observable at room temperature. Distortions of the benzene molecule from D 6h symmetry ascribed to Ag+...C6H6 interactions are small, but significant. At 18 K the two C—C bonds complexed by Ag+ are 1.405 (1) Å in length; the other four are 1.398 (1) Å. The C—H bonds are equal in length at 1.087 (2) (two) and 1.089 (1) Å (four). The H atoms nearest to Ag+ are displaced 0.064 (1) Å from the C6 plane, away from the silver. The shortest Ag+...C distance of the complex is 2.565 (1) Å. This value and bond lengths of the benzene molecule are invariant between 18 and 158 K within 2 e.s.d.'s or less. The nonequivalent bond lengths of ClO^{-}_4, 1.451 (1) (two) and 1.441 (1) Å (two) at 18 K, are foreshortened by −0.007 and −0.005 Å at 158 K by effects of thermal motion. The O—Cl—O angles, 109.08 (7), 109.98 (2) and 107.83 (8)° at 18 K, are virtually unchanged by temperature. The Ag+...ClO^{-}_4 interactions occur at Ag+...O distances of 2.785 (1) and 2.612 (1) Å (18 K), where the shorter values involve ClO^{-}_4 acting as a bidentate group. Rigid-body and riding-motion models do not adequately account for the observed temperature dependence of bond lengths in ClO^{-}_4 nor provide significant corrections to the C6H6 bond lengths at 18, 78 and 158 K beyond their uncertainty limits. A harmonic potential rationalizes the motion of Ag+ at these three temperatures.

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Wagner, Márcia Fortes. "Editorial". Revista de Psicologia da IMED 1, n. 1 (1 giugno 2009): 2. http://dx.doi.org/10.18256/2175-5027.2009.v1i1.5.

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Mukhopadhyay, Amartya, Sudhakar Venkatesh, Poh Sun Goh e Tow Keang Lim. "Use of D-dimer and Lower Extremity Doppler Ultrasound Results to Obviate the Need for Computerised Tomographic Pulmonary Angiography". Annals of the Academy of Medicine, Singapore 35, n. 12 (5 dicembre 2006): 858–63. http://dx.doi.org/10.47102/annals-acadmedsg.v35n12p858.

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Introduction: We hypothesise that correct interpretation of other diagnostic tests could reduce the use of computerised tomographic pulmonary angiogram (CTPA) examinations in patients with suspected pulmonary embolism (PE). Materials and Methods: We carried out a retrospective analysis of 158 patients in a 928-bed university hospital. These consecutive patients were investigated for suspected PE from May 2001 to February 2002 using CTPA. Results: There were 74 men and 84 women with a mean (±SD) age of 57 (±19) years. Overall, 56% of patients (89/158) showed clinically significant abnormalities on the CTPA examination. The overall prevalence of PE was 15% (24/158). The D-dimers were assayed in 40% (63/158) and lower limbs were scanned with Doppler ultrasound (US) in 22% (35/158) of patients. None of the 19 patients with negative D-dimer assays had PE. Of the patients who were positively tested on Doppler US, 4 were positive and 1 was negative for PE on the CTPA. None of the patients with positive Doppler US had negative D-dimer test. In retrospect, patient management based on negative D-dimer assays and positive lower extremity Doppler US studies could have reduced the need for further investigation with CTPA by 15% (24/158). Conclusion: In patients with suspected PE, correct interpretation of D-dimer and leg Doppler US tests may reduce the demand for CTPAs. Key words: CTPA, D-dimer, Doppler ultrasound, Spiral CT

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Palka, Przemysław, e Marzena Przetak. "Rzecz o tym, jak ustawodawca powiedział to, czego powiedzieć nie zamierzał – uwagi na temat art. 158 § 1 Kodeksu karnego". Studia Iuridica, n. 83 (19 febbraio 2021): 158–76. http://dx.doi.org/10.31338/2544-3135.si.2020-83.10.

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The article concerns two legal and linguistic opinions which are a legal analysis of the article 158 item 1 of the Criminal Code. The authors claim that this regulation (its wording) has been a considerable divergence ever since the Criminal Code entered into force in 1997. Legally, it means the divergence between what the legislator said and what he possibly intended to say. According to the authors, the legislator’s communicative intention was not implemented in this case. The reason for this was the fact that the analized fragment (the article 158 item 1) of the legal text (the current Criminal Code in Poland), which is an important tool for social impact, does not meet the demands made for legal texts: clarity, comprehension, and explicitness. The divergence shown in the article is associated with the legislator’s use of the pronoun “which/who” and the phrase “the man is exposed to occurrence”. Morover, the analysis of the article 158 item 1 of the Criminal Code conducted by the authors contains clues. They allow this regulation to be drafted in such a way as to reflect the intentions of the legislator.

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Иванов, С. А., О. Г. Хоров, Н. П. Челебиева, А. В. Черныш, Г. Л. Грабарева e К. С. Артемчик. "Acquired Defects of the External Nose in Patients of the Gomel Region: Demographic and Clinical Characteristics". Оториноларингология. Восточная Европа 14, n. 2 (28 maggio 2024): 264–74. http://dx.doi.org/10.34883/pi.2024.14.2.039.

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Цель. Исследовать демографические показатели и клинические параметры у пациентов с дефектами наружного носа. Материалы и методы. Исследованы данные 382 пациентов с приобретенными дефектами наружного носа. Выполнено сравнение демографических и клинических параметров в зависимости от причины дефекта. Результаты. Дефекты наружного носа были следствием хирургического лечения рака кожи в 190 случаях (49,7%), следствием механической травмы – в 158 случаях (41,4%). Среди пациентов с пострезекционными дефектами (группа 1) преобладали лица женского пола (130 из 224, 58,0%), медиана возраста составила 72 (63; 80) года. Среди пациентов с посттравматическими дефектами (группа 2) преобладали мужчины (112 из 158, 70,9%), медианный возраст – 43 (29; 57) года. Не отмечено статистически значимого различия между группами по числу вовлеченных анатомических частей носа. В группе 1 статистически значимо чаще, чем в группе 2, встречались дефекты с вовлечением субдермальных структур – 33,5% и 9,5% соответственно, р<0,001. Повреждение дистальных субъединиц более часто наблюдалось при пострезекционных дефектах (35,7%), чем после травм (8,9%), различие статистически значимое, р<0,001. Пластическое замещение дефекта было выполнено у пациентов группы 1 в 153 случаях из 224 (68,3%), в группе 2 – в 1 случае из 158 (0,6%), различие статистически значимое, р<0,001. Заключение. Установлены демографические и клинические особенности приобретенных дефектов наружного носа после удаления патологических образований кожи и после механических травм. Purpose. To study demographic indicators and clinical parameters in patients with defects of the external nose. Materials and methods. The data of 382 patients with acquired defects of the external nose were studied. Demographic and clinical parameters were compared depending on the defect reason. Results. Defects of the external nose developed as a result of skin cancer surgery in 190 cases (49.7%), and as a result of mechanical trauma in 158 cases (41.4%). Among patients with post-resection defects (group 1), females predominated (130 out of 224, 58.0%), with median age of 72 (63; 80) years. Among patients with post-traumatic defects (group 2), men predominated (112 out of 158, 70.9%), with median age of 43 (29; 57) years. The number of involved nasal subunits didn’t show statistically significant difference between the groups. In group 1, defects involving subdermal structures were statistically significantly more common than in group 2: 33.5% and 9.5%, respectively, p<0.001. Damage of the distal subunits was more common in post-resection defects (35.7%) than after trauma (8.9%); the difference was statistically significant, p<0.001. Reconstruction of the defect has been performed in patients of group 1 in 153 cases of 224 (68.3%), and in 1 case of 158 (0.6%) in group 2; the difference was statistically significant, p<0.001. Conclusion. The demographic and clinical features of acquired defects of the external nose after skin lesion resection and after mechanical injuries were established.

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Editora, La. "Ley Fundamental de Educación. Decreto 262-2011. Gaceta # 32,754. 22 de Febrero del 2012". La Revista de Derecho 33 (28 novembre 2013): 129–58. http://dx.doi.org/10.5377/lrd.v33i0.1264.

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Singh, Vivek. "In memoriam : Frederick Sanger (1918-2013)". International Journal of Applied Sciences and Biotechnology 1, n. 4 (21 dicembre 2013): 158–61. http://dx.doi.org/10.3126/ijasbt.v1i4.9313.

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Sinclair, Megan. "Lessons Drawn: Essays on the Pedagogy of Comics and Graphic Novels, David Seelow (2019)". Studies in Comics 11, n. 1 (1 luglio 2020): 228–31. http://dx.doi.org/10.1386/jem_00025_5.

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Manik, Rahmat GM. "Pemutusan Hubungan Kerja Atas Kesalahan Berat setelah Pasal 158 Undang-Undang Nomor 13 Tahun 2003 Tentang Ketenagakerjaan Dicabut Oleh Putusan Mahkamah Konstitusi Nomor 012/PUU-I/2003". Melayunesia Law 1, n. 1 (1 dicembre 2017): 65. http://dx.doi.org/10.30652/mnl.v1i1.4505.

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Abstract Article 158 Paragraph (1) of the Employment Act has been repealed by the Constitutional Court in Decision N0.012/PUU-I/2003. Then legal vacuum concerning Termination of Employment for major offenses. Government issued Circular Letter No.SE-13/MEN/SJ-HK/I/2005, which states the Firm Termination due to severe error, can be done after decision of the criminal judge finalized. This type of research is normative. Data were analyzed qualitatively, concluding with the deductive method of thinking. Results First, the concept of Termination On serious mistakes After Section 158 of the Employment Act is repealed by the Constitutional Court Termination Of workers who make mistakes should heavy Decision Criminal Justice Stay. While the workers who perform heavy Mistake that are not criminal acts lack a legal basis. Second, the concept of Termination On serious mistakes After Section 158 of the Employment Act repealed by the Constitutional Court illustrate the lack of protection for workers who perform heavy errors beyond the provisions of Criminal.Abstrak Pasal 158 Ayat (1) UU Ketenagakerjaan telah dicabut oleh MK melalui putusan No.012/PUU-I/2003. Dengan demikian terjadi kekosongan hukum mengenai PHK karena kesalahan berat. Pemerintah menerbitkan SE No.SE-13/MEN/SJ-HK/I/2005, yang menyatakan Pengusaha yang melakukan PHK karena kesalahan berat, dapat dilakukan setelah ada putusan hakim pidana berkekuatan tetap. Jenis penelitian adalah normatif. menganalisis hukum yang tertulis. Data dianalisi secara kualitatif, penarikan kesimpulan dengan metode berfikir deduktif. Hasil Pertama, Konsep PHK Atas Kesalahan Berat Setelah Pasal 158 UU Ketenagakerjaan dicabut oleh MK yaitu PHK Terhadap pekerja yang melakukan kesalahan berat harus ada Putusan Hakim Pidana Tetap. Sementara terhadap pekerja yang melakukan kesalahan berat yang bukan tindak pidana tetapi diatur sebagai kesalahan berat belum memiliki dasar hukum. Kedua, Konsep PHK Atas Kesalahan Berat Setelah Pasal 158 UU Ketenagakerjaan dicabut Oleh MK menggambarkan tidak adanya perlindungan terhadap pekerja yang melakukan kesalahan berat diluar ketentuan Pidana.

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Sinclair, Megan. "Lessons Drawn: Essays on the Pedagogy of Comics and Graphic Novels, David Seelow (2019)". Studies in Comics 11, n. 1 (1 luglio 2020): 228–31. http://dx.doi.org/10.1386/stic_00025_5.

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Pelletier, Gérard. "Morisset, Jean (1985) L’identité usurpée 1) l’Amérique écartée. Montréal, Nouvelle Optique, 158 p." Cahiers de géographie du Québec 30, n. 79 (1986): 83. http://dx.doi.org/10.7202/021773ar.

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Henry Ellis, F., Robert E. Crozier e Elton Watkins. "Esophagomyotomy for achalasia Clinical results 1 to 16 ½ years after 158 consecutive operations". Diseases of the Esophagus 1, n. 2 (1 agosto 1988): 81–85. http://dx.doi.org/10.1093/dote/1.2.81.

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Hüntrup, G., T. Streibel, E. Winkel, M. Kurth, H. Röcher e W. Heinrich. "Study of fragmentation interactions at beam energies from 1 to 158 A GeV". Radiation Measurements 28, n. 1-6 (gennaio 1997): 323–28. http://dx.doi.org/10.1016/s1350-4487(97)00092-9.

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Yan, Nan, Peter Cherepanov, Janet E. Daigle, &NA; Alan e Judy Lieberman. "158 The SET complex acts as a barrier to autointegration of HIV-1". JAIDS Journal of Acquired Immune Deficiency Syndromes 51 (giugno 2009): 1. http://dx.doi.org/10.1097/01.qai.0000351113.80299.b3.

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Ivanković, Damir, Erica Barbazza, Véronique Bos, Óscar Brito Fernandes, Kendall Jamieson Gilmore, Tessa Jansen, Pinar Kara et al. "Features Constituting Actionable COVID-19 Dashboards: Descriptive Assessment and Expert Appraisal of 158 Public Web-Based COVID-19 Dashboards". Journal of Medical Internet Research 23, n. 2 (24 febbraio 2021): e25682. http://dx.doi.org/10.2196/25682.

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Background Since the outbreak of COVID-19, the development of dashboards as dynamic, visual tools for communicating COVID-19 data has surged worldwide. Dashboards can inform decision-making and support behavior change. To do so, they must be actionable. The features that constitute an actionable dashboard in the context of the COVID-19 pandemic have not been rigorously assessed. Objective The aim of this study is to explore the characteristics of public web-based COVID-19 dashboards by assessing their purpose and users (“why”), content and data (“what”), and analyses and displays (“how” they communicate COVID-19 data), and ultimately to appraise the common features of highly actionable dashboards. Methods We conducted a descriptive assessment and scoring using nominal group technique with an international panel of experts (n=17) on a global sample of COVID-19 dashboards in July 2020. The sequence of steps included multimethod sampling of dashboards; development and piloting of an assessment tool; data extraction and an initial round of actionability scoring; a workshop based on a preliminary analysis of the results; and reconsideration of actionability scores followed by joint determination of common features of highly actionable dashboards. We used descriptive statistics and thematic analysis to explore the findings by research question. Results A total of 158 dashboards from 53 countries were assessed. Dashboards were predominately developed by government authorities (100/158, 63.0%) and were national (93/158, 58.9%) in scope. We found that only 20 of the 158 dashboards (12.7%) stated both their primary purpose and intended audience. Nearly all dashboards reported epidemiological indicators (155/158, 98.1%), followed by health system management indicators (85/158, 53.8%), whereas indicators on social and economic impact and behavioral insights were the least reported (7/158, 4.4% and 2/158, 1.3%, respectively). Approximately a quarter of the dashboards (39/158, 24.7%) did not report their data sources. The dashboards predominately reported time trends and disaggregated data by two geographic levels and by age and sex. The dashboards used an average of 2.2 types of displays (SD 0.86); these were mostly graphs and maps, followed by tables. To support data interpretation, color-coding was common (93/158, 89.4%), although only one-fifth of the dashboards (31/158, 19.6%) included text explaining the quality and meaning of the data. In total, 20/158 dashboards (12.7%) were appraised as highly actionable, and seven common features were identified between them. Actionable COVID-19 dashboards (1) know their audience and information needs; (2) manage the type, volume, and flow of displayed information; (3) report data sources and methods clearly; (4) link time trends to policy decisions; (5) provide data that are “close to home”; (6) break down the population into relevant subgroups; and (7) use storytelling and visual cues. Conclusions COVID-19 dashboards are diverse in the why, what, and how by which they communicate insights on the pandemic and support data-driven decision-making. To leverage their full potential, dashboard developers should consider adopting the seven actionability features identified.

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Nepali, Kul Bahadur, Ramesh Raj Pant e Sadhana Pradhanang. "Impacts of Climate Change on the Livelihoods of Local People: A Case from Jethal V.D.C., Sindhupal-Chowk District". Crossing the Border: International Journal of Interdisciplinary Studies 2, n. 1 (28 luglio 2014): 147–58. http://dx.doi.org/10.3126/ctbijis.v2i1.10820.

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Levina, Febri, M. Anas Anasiru, Salman Salman e Mutia Reski Amalia. "GAMBARAN STATUS GIZI SISWA SDN 61 KOTA TIMUR KOTA GORONTALO". JOURNAL HEALTH AND NUTRITIONS 7, n. 1 (25 novembre 2022): 1. http://dx.doi.org/10.52365/jhn.v7i1.452.

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ABSTRACT School children are one of the nutritionally vulnerable groups who need attention to their nutritional status so that in the future they become quality human resources. This study aims to describe the nutritional status of students at SDN 61 Kota Timur Gorontalo City. The research method used is descriptive research. The population is students in grades II, III, IV, and V at SDN 61 Kota Timur Gorontalo City totaling 260 people. The sample of this study amounted to 158 people. The variables in this study are independent variables, namely the description of nutritional status. The results showed that from 158 respondents who were categorized as undernourished, 2 people (1.2%), good nutrition (normal) amounted to 88 people (55.8%), at risk of overnutrition amounted to 38 people (24%), over nutrition totaled 22 people (13.9%) and obesity amounted to 8 people (5%). Respondents in the very short category are 1 person (0.63%), short are 8 people (5.0%), normal are 142 people (89.8%), high are 7 people (4.4%) respondents. The study concludes that of the 158 students who were sampled, all of them were included in the good nutrition category, but there was 1 person (0.63% included in the very short category). ABSTRAK Anak sekolah merupakan salah satu kelompok rawan gizi yang perlu mendapatkan perhatian keadaan gizinya, agar di kemudian hari mereka menjadi sumber daya manusia yang berkualitas. Penelitian ini bertujuan untuk mengetahui gambaran status gizi siswa di SDN 61 Kota Timur Kota Gorontalo. Metode penelitian yang digunakan yaitu penelitian deskriptif. Populasi yaitu siswa/siswi kelas II, III, IV dan V SDN 61 Kota Timur Kota Gorontalo berjumlah 260 orang. Sampel penelitian ini berjumlah 158 orang. Variable dalam penelitian ini adalah variabel mandiri yaitu gambaran status gizi. Hasil Penelitian menunjukan dari 158 responden yang termasuk kategori gizi kurang berjumlah 2 orang (1,2%) , gizi baik (normal) berjumlah 88 orang (55,8%), beresiko gizi lebih berjumlah 38 orang (24%), gizi lebih berjumlah 22 orang (13,9%) dan obesitas berjumlah 8 orang (5%). Responden dengan kategori sangat pendek 1 orang (0,63%) , pendek berjumlah 8 orang (5,0%),normal berjumlah 142 orang (89,8%) , tinggi berjumlah 7 orang (4,4%) responden. Kesimpulan penelitian adalah dari 158siswa yang dijadikan sampel seluruhnya termasuk dalam kategori gizi baik,namunterdapat 1 orang (0,63% termasuk kategori sangat pendek.

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Cox, Susanne. "Beethovens Volksliedbearbeitungen WoO 158". Die Musikforschung 71, n. 2 (22 settembre 2021): 132–45. http://dx.doi.org/10.52412/mf.2018.h2.303.

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Es werden bei den Volksliedbearbeitungen WoO 158 vor allem drei Arbeitsmethoden erkennbar: 1) Übernahme des Notentextes der Vorlage vollständig oder nur mit kleinen Änderungen - hier schrieb Beethoven nur Teile seiner Liedbearbeitung in der autographen Partitur nieder; 2) Übernahme des in größerem Umfang veränderten Notentextes, bei der Beethoven zuerst die beibehaltenen und danach die hinzukomponierten Stellen notierte; 3) Übernahme nur der zuerst aufgeschriebenen Liedmelodie - dies ist die einzige Arbeitsmethode, zu der Skizzen existieren.

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Sayudi, Akbar, Rico Andrian Nahampun e Gusti Mauritza. "Penyelesaian Perselisihan Ketenagakerjaan Karena Kesalahan Berat Pasca Putusan Mahkamah Konsitusi Nomor 012/PUU/-I/2003". JURNAL HUKUM PELITA 2, n. 2 (24 novembre 2021): 59–69. http://dx.doi.org/10.37366/jh.v2i2.892.

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Hubungan industrial sering kali mengalami permasalahan, salah satu contohnya ialah permasalahan terkait perselisihan hubungan kerja yanng dikarenakan kesalahan berat yang dibuat oleh pekerja. Undang-undang Nomor 13 Tahun 2003 tentang Ketenagakerjaan pasal 158 pengusaha diberikan ruang untuk dapat melakukan pemutusan hubungan kerja terhadap pekerja/buruh yang melakukan kesalahan berat sebagaiman yang terurai dalam pasal 158 ayat (1) huruf a sampai dnegan huruf j. Namun, Mahkamah Konstitusi melalui Putusan Nomor 012/PUU/-I/2003 menyatakan bahwa pasal 158 Undang-Undang Ketenagakerjaan bertentangan dengan Undang-Undang dan tidak mempunyai kekuatan mengikat. lantas bagaimana penyelelesaian perselisihan ketenagakerjaan pasca putusan Mahkamah Konstitusi Nomor 012/PUU/-I/2003. Penelitian ini meggunakan metode pendekatan yuridis-normatif dengan menggunakan data hukum sekunder. Penelitian ini bertujuan untuk menganalisis putusan Mahkamah Agung Nomor 1112 K/Pdt.Sus-PHI/2017 yang masih belum sejalan dengan Putusan Mahkamah Konstitusi Nomor 012/PUU/-I/2003.

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Akermann, Manfred, e Heinz Bardua. "Rezension von: Bardua, Heinz (Bearb.), Die Kreis- und Gemeindewappen im Regierungsbezirk Stuttgart". Württembergisch Franken 72 (2 novembre 2023): 390–91. http://dx.doi.org/10.53458/wfr.v72i.8243.

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Yang, Guang, Christina Hanzis, Sigitas Verselis, Lian Xu, Zachary Hunter, Leukothea Ioakimidis, Patricia Sheehy, Christopher Patterson, Edward Fox e Steven P. Treon. "The Anti-CD20 Monoclonal Antibody GA101 Displays More Robust Anti-Tumor Activity Versus Rituximab In Waldenstrom's Macroglobulinemia (WM)". Blood 116, n. 21 (19 novembre 2010): 4904. http://dx.doi.org/10.1182/blood.v116.21.4904.4904.

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Abstract Abstract 4904 Background: Rituximab is an IgG class CD20-directed monoclonal antibody used in the treatment of B-cell malignancies, including WM. We and others have previously demonstrated dependence for IgG class therapeutic antibodies on polymorphisms at FcγRIIIA-158. Approximately half of WM patients express V/V or V/F, and the remainder half express F/F at this polymorphic locus. Patients with WM expressing FcγRIIIA-158 V/V or V/F show improved rituximab single agent activity, as well as attainment of deeper responses (VGPR or CR) with combination Rituximab therapy. GA101 is a novel humanized anti-CD20 antibody with a glyco-engineered Fc domain that exhibits increased Fcg receptor binding and ADCC activity. Methods: In this study, we examined the in vitro activity of GA101 and Rituximab against WM cells, and also examined the activity of these antibodies in context of FcγRIIIA-158 polymorphisms. ADCC activity for GA101 and Rituximab was assessed using genotyped healthy donor derived NK cells against BCWM.1 WM cells, as well autologous NK cells against the patient's own lymphoplasmacytic cells. In vitro B-cell depletion and direct cell death induction assays were also performed. Results: We observed significantly greater ADCC activity against WM cells for GA101 versus Rituximab in both healthy donor, as well as autologous NK cell assays. GA101 mediated ADCC activity was particularly more robust versus Rituximab in patients expressing FcγRIIIA-158 F/F versus V/V or V/F (Figure 1). In addition, GA101 induced significant direct cell death against WM lymphoplasmacytic cells, as well as in vitro B-cell depletion assays in comparison to Rituximab, which exhibited little direct cell death induction activity. Nuclear translocation of apoptosis inducing factor (AIF) was observed following GA101 by immunofluorescence microscopy. Conclusions: GA101 is associated with enhanced ADCC activity relative to Rituximab by NK cells, particularly for those subjects expressing FcγRIIIA-158 F/F. In addition, GA101 demonstrated direct cell death in WM lymphoplasmacytic cells through an AIF mediated caspase-independent pathway. These studies provide the framework for the investigation of GA101 in WM, and suggest particular benefit for those patients who express FcγRIIIA-158 F/F. Disclosures: No relevant conflicts of interest to declare.

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Sørensen, Henrik H. "Wang Yongbo & Lothar Ledderose (eds.): Buddhist Stone Sutras in China: Shandong Province, Vol. 1." Entangled Religions 2 (22 gennaio 2015): VIII—XIV. http://dx.doi.org/10.46586/er.v2.2015.viii-xiv.

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This contribution offers a review of Wang Yongbo's and Lothar Ledderose'sBuddhist Stone Sutras in China: Shandong Province, Vol. 1.Hangzhou and Wiesbaden: Harrassowitz and China Academy of Art Press, 2014. XXIV + 506 pages, hardcover € [D] 158, ISBN 978–3–447–06931–1.

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Cruz-de la Cruz, Leidy Laura, Teodoro Espinosa-Solares, Miguel Angel Aguilar-Méndez, Diana Guerra-Ramírez e Guadalupe Hernández-Eugenio. "Influence of microwave drying process on microstructure and thermodynamic properties of nopal cladodes". Ingeniería Agrícola y Biosistemas 12, n. 2 (2020): 115–30. http://dx.doi.org/10.5154/r.inagbi.2019.12.075.

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Introduction: The drying of nopal offers an alternative for their preservation, storage, handling and consumption. Objective: The effects of microwave drying on the microstructural characteristics of nopal and their thermodynamic properties at the food-water interface were evaluated. Methodology: Nopal cladodes were microwave-dried by applying powers of 75 and 158 kW∙kg-1. Microstructure of the samples was evaluated by Scanning Electron Microscope. Adsorption isotherms were determined at temperatures of 10, 20, 30 and 40 °C. Net isosteric heat (q-st) was calculated using the Clausius-Clapeyron equation and the Peleg model. Results: Samples dehydrated at 75 kW∙kg-1 showed greater preservation of their internal and external structure. When applying a higher power (158 kW∙kg-1), greater damage was observed in the microstructure of the material. Type III adsorption isotherm curves were obtained according to the Brunauer classification. The q-st of the dehydrated nopal was 7.51 kJ∙mol-1 for a moisture content of 0.05 kgH2O∙kg-1. Limitations of the study: The results obtained are valid only for microwave drying by applying powers of 75 and 158 kW∙kg-1. Originality: This work proposes the microwave drying of nopal as an alternative method that reduces drying time and allows the preservation of the material’s structural properties. Conclusions: The power applied in the microwave drying of nopal had a direct impact on the microstructure of the samples. The use of a power of 75 kW∙kg-1 was the best drying condition to preserve the structures constituting the cladodes.

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Erkek, Esra Turan, Seydahmet Akin, Yasemin Ozgur, Zeki Aydin e Zerrin Bicik. "Comparison of Dipper and Non-Dipper Hypertension Patterns According to Chronic Kidney Disease Stage". Journal of Nephrology Advances 1, n. 2 (24 settembre 2019): 15–23. http://dx.doi.org/10.14302/issn.2574-4488.jna-19-3008.

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Introduction Hypertension is a major cardiovascular risk factor. There is a strong relationship between blood pressure (BP) elevation and stroke, myocardial infarction, heart failure and mortality due to kidney disease. It is known that the loss of the dipping pattern in hypertension is associated with increased target organ damage. In our study, we aimed to investigate the prevalence of dipper hypertension (DHT) and nondipper hypertension (NDHT) and related factors in patients with stage 1 and 2 chronic kidney disease (CKD). Materials and Methods A total of 158 patients diagnosed with stage 1 or stage 2 CKD were included in the study. Demographic characteristics, anthropometric measurements, physical examination findings and laboratory results of the patients were recorded. Ambulatory BP monitoring was performed in all patients. Results Of the 158 patients (female n: 98), 78 (49%) were in the stage 1 CKD group and 80 (51%) were in the stage 2 CKD group. No significant difference was observed in the prevalence of DHT or NDHT between hypertensive patients in the stage 1 and 2 CKD groups. The rate of NDHT was 59.5% (94/158 patients). Female patients had more DHT in the general population and in the stage 1 group than male patients (p=0.05, p=0.01, respectively). Conclusion No significant difference was observed in the prevalence of DHT or NDHT between hypertensive patients in the stage 1 and 2 CKD groups. The prevalence of DHT in female patients was significantly higher in both groups than in men in both groups, but especially in the stage 1 CKD group.

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Cao, Qi, Guoqing Ning, Fan Yang, Ye Wang, Bofeng Li e Xinlong Ma. "Hierarchically porous activated carbons prepared via a dissipative process: a high-capacity cathode for Li-ion capacitors". Nanoscale 14, n. 3 (2022): 691–99. http://dx.doi.org/10.1039/d1nr05506b.

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Hierarchically porous activated carbons (PACs) are synthesized by a tableting-activation method. As a cathode for LICs, the optimal PACs exhibit an ultrahigh specific capacity of 251 mA h g−1 at 0.5 A g−1 and still retain 158 mA h g−1 at 15 A g−1.

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Garvey, T., C. Kane, A. Plumb, R. Vega e E. Seward. "PTH-158 The Potential Financial Benefit of Using CT Colonography in Selected Patients Referred on a Suspected Colorectal Cancer Pathway: Abstract PTH-158 Table 1". Gut 65, Suppl 1 (giugno 2016): A297.2—A298. http://dx.doi.org/10.1136/gutjnl-2016-312388.561.

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Pramanik, Baisakhi. "A comparative study on the knowledge, attitude and risk perception regarding complications of type-2 diabetes mellitus between male and female diabetic patients attending diabetic clinics in selected hospital of West Bengal, India". INTERNATIONAL JOURNAL OF EXPERIMENTAL RESEARCH AND REVIEW 15 (30 aprile 2018): 16–27. http://dx.doi.org/10.52756/ijerr.2018.v15.004.

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Diabetes, a major health problem has shaken quite a huge population of India. This present study was conducted to assess the knowledge, attitude and risk perception regarding complications of Type-2 Diabetes mellitus between male and female Diabetic patients attending Diabetic Clinics of Medical College & Hospital, Kolkata, West Bengal. Conceptual framework of the study was based on Health Belief Model. Comparative survey design was adopted for the study. 160 samples selected by non-probability purposive sampling technique. The results revealed that 83.75% male & 82.50% female patients had average knowledge. Majority of respondents (58% male and 61% female ) had favourable attitude. Only 22.50% male and 30% female had good risk perception. There was statistically significant relationship between knowledge and attitude [rdf(158) = 0.202*], knowledge and risk perception [rdf(158) = 0.317*] & attitude and risk perception [rdf(158) = 0.23*] of diabetes complication at 0.05 level of significance. No significant difference was found between male and female diabetic patients regarding knowledge, attitude and risk perception. Significant association found between knowledge with education [ χ2df(1) =18.44*], and attitude with education [χ2df(1) =12.33*] and risk perception with duration of disease [χ2df(1) = 16.682*]. Hence the result emphasized on necessity of health education for improving the knowledge of diabetes patients so that they can develop favourable attitude and perceive the risk of diabetes complications.

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43

Spagnoli, Anna, Pierluigi Navarra, Stenlios Tsagarakis, Gian Luigi Spadoni e Ashley B. Grossmann. "158 IN VITRO ACURATE RELEASE OF SOMATOSTAIN FROM RAT HYPOTHALAMUS: EFFECT OF IL-1". Pediatric Research 30, n. 6 (dicembre 1991): 654. http://dx.doi.org/10.1203/00006450-199112000-00188.

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44

Dai, Lili, Dexi Chen, Ying Shi, Yasong Wu, Honghai Zhang, Yali Liu, Tong Zhang, Lianchun Liang e Hao Wu. "PP-158 Development of HIV-1 laboratory diagnostic assay based on the multiplex PCR". International Journal of Infectious Diseases 13 (agosto 2009): S91. http://dx.doi.org/10.1016/s1201-9712(09)60552-x.

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45

Caruso, Arnaldo, Francesca Caccuri, Anna Magiera, Simona Fiorentini e Cinzia Giagulli. "158 HIV-1 Matrix Protein p17: A Candidate Antigen for Therapeutic Vaccines Against AIDS". JAIDS Journal of Acquired Immune Deficiency Syndromes 56 (aprile 2011): 66. http://dx.doi.org/10.1097/01.qai.0000397344.07803.7a.

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46

Wolfire, Mark G., David Hollenbach e A. G. G. M. Tielens. "The correlation of C II 158 micron and CO (J = 1 - 0) line emission". Astrophysical Journal 344 (settembre 1989): 770. http://dx.doi.org/10.1086/167841.

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47

HUANG, J. T., L. C. CHEN, L. WANG, M. H. KIM, J. A. WARSHAW, D. ARMSTRONG, Q. Y. ZHU et al. "ChemInform Abstract: Nucleosides. Part 158. Fluorinated Sugar Analogues of Potential Anti- HIV-1 Nucleosides." ChemInform 22, n. 45 (22 agosto 2010): no. http://dx.doi.org/10.1002/chin.199145290.

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48

West, John B. "Understanding pulmonary gas exchange: ventilation-perfusion relationships". American Journal of Physiology-Lung Cellular and Molecular Physiology 287, n. 6 (dicembre 2004): L1071—L1072. http://dx.doi.org/10.1152/classicessays.00024.2004.

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This essay looks at the historical significance of four APS classic papers that are freely available online: Fenn WO, Rahn H, and OTIS AB. A theoretical study of the composition of the alveolar air at altitude. Am J Physiol 146: 637-653. 1946 ( http://ajplegacy.physiology.org/cgi/reprint/146/5/637 ). Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949 ( http://ajplegacy.physiology.org/cgi/reprint/158/1/21) ). Riley RL. And Cournand A. "Ideal" Alveolar air and the analysis of ventilation-perfusion relationships in the lungs. J Appl Physiol 1: 825-847. 1949 ( http://jap.physiology.org/cgi/reprint/1/12/825) . Riley RL. And Cournand A. Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs: theory. J Appl Physiol 4: 77-101. 1951 ( http://jap.physiology.org/cgi/reprint/4/2/77) .

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49

West, John B. "Understanding pulmonary gas exchange: ventilation-perfusion relationships". Journal of Applied Physiology 97, n. 5 (novembre 2004): 1603–4. http://dx.doi.org/10.1152/classicessays.00024a.2004.

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Abstract (sommario):

This essay looks at the historical significance of four APS classic papers that are freely available online: Fenn WO, Rahn H, and Otis AB. A theoretical study of the composition of the alveolar air at altitude. Am J Physiol 146: 637—653, 1946 ( http://ajplegacy.physiology.org/cgi/reprint/146/5/637 ). Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21—30, 1949 ( http://ajplegacy.physiology.org/cgi/reprint/158/1/21 ). Riley RL and Cournand A. “Ideal” alveolar air and the analysis of ventilation-perfusion relationships in the lungs. J Appl Physiol 1: 825—847, 1949 ( http://jap.physiology.org/cgi/reprint/1/12/825 ). Riley RL and Cournand A. Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs: theory. J Appl Physiol 4: 77—101, 1951 ( http://jap.physiology.org/cgi/reprint/4/2/77 ).

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50

Obeid, Obeid E., e Alhusain J. Alzahrani. "Analysis of chemokines and soluble adhesion molecules in cytomegalovirus-positive renal transplant recipients". Journal of Infection in Developing Countries 4, n. 02 (28 dicembre 2009): 110–13. http://dx.doi.org/10.3855/jidc.592.

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Background: The relationship among cytomegalovirus (CMV) infection and the serum level of chemokines and soluble adhesion molecules is not well studied. This study aimed to assess chemokines and soluble adhesion molecules in CMV-positive Saudi renal transplant recipients. Methodology: The study was conducted in a tertiary hospital in Eastern Saudi Arabia over a 12-month period. All kidney transplant recipients who regularly attended the nephrology clinics were included (n = 150). Randomly selected age- and sex-matched individuals served as a control group (n = 158). CMV antibodies (IgG and IgM), chemokines and soluble adhesion molecules were measured using standard enzyme-linked immunosorbent assay (ELISA). CMV viral DNA was detected using real time polymerase chain reaction (PCR). Results: Of the 150 patients studied, 149 (n = 150) had detectable levels of Anti-CMV IgG antibodies (99.3%). In the control group, 113 (n = 158), blood donors had anti-CMV IgG antibodies (71.5%). Forty-one (n = 150) kidney transplant recipients were positive for anti-CMV IgM antibodies (27.3%), whereas only one (n = 158) blood donor had detectable anti-CMV IgM antibodies. All IgM positive samples contained CMV viral DNA. MCP-1, IL-8, ICAM-1, and VCAM-1 levels were measured using ELISA. Of those, only MCP-1 and IL-8 were detectable. Eighteen kidney transplant recipients were positive for MCP-1 (12%). All MCP-1 patients were also anti-CMV IgM positive, while 5 patients had detectable levels of IL-8 (3.3%). All these patients were CMV IgM-positive. Conclusions: The increase in chemokine levels during CMV infection may reflect a possible role for these molecules in the immunopathogenesis of CMV infection in this study population.

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