Letteratura scientifica selezionata sul tema "153.7/5"

Background:Systemic lupus erythematosus (SLE) is an autoimmune disease mainly affecting women of childbearing age. The interplay between genetic and environmental factors may contribute to disease pathogenesis1. At today, no robust data are available about the possible contribute of diet in SLE. Caffeine, one of the most widely consumed products in the world, seems to interact with multiple components of the immune system by acting as a non-specific phosphodiesterase inhibitor2.In vitrodose-dependent treatment with caffeine seems to down-regulate mRNA levels of key inflammation-related genes and similarly reduce levels of different pro-inflammatory cytokines3.Objectives:We evaluated the impact of caffeine consumption on SLE-related disease phenotype and activity, in terms of clinimetric assessment and cytokines levels.Methods:We performed a cross-sectional study, enrolling consecutive patients and reporting their clinical and laboratory data. Disease activity was assessed by SLE Disease Activity Index 2000 (SLEDAI-2k)4. Caffeine intake was evaluated by a 7-day food frequency questionnaire, including all the main sources of caffeine. As previously reported, patients were divided in four groups according to the daily caffeine intake: <29.1 mg/day (group 1), 29.2-153.7 mg/day (group 2), 153.8-376.5 mg/day (group 3) and >376.6 mg/day (group 4)5. At the end of questionnaire filling, blood samples were collected from each patient to assess cytokines levels. These were assessed by using a panel by Bio-Plex assays to measure the levels of IL-6, IL-10, IL-17, IL-27, IFN-γ, IFN-α and Blys.Results:We enrolled 89 SLE patients (F/M 87/2, median age 46 years, IQR 14; median disease duration 144 months, IQR 150). The median intake of caffeine was 195 mg/day (IQR 160.5). At the time of the enrollment, 8 patients (8.9%) referred a caffeine intake < 29.1 mg/day (group 1), 27 patients (30.3%) between 29.2 and 153.7 mg/day (group 2), 45 patients (51%) between 153.8 and 376.5 mg/day (group 3) and 9 patients (10.1%) >376.6 mg/day (group 4). A negative correlation between the levels of caffeine and disease activity, evaluated with SLEDAI-2K, was observed (p=0.01, r=-0.26). By comparing the four groups, a significant higher prevalence of lupus nephritis, neuropsychiatric involvement, haematological manifestations, hypocomplementemia and anti-dsDNA positivity was observed in patients with less intake of caffeine (figure 1 A-E). Furthermore, patients with less intake of caffeine showed a significant more frequent use of glucocorticoids [group 4: 22.2%,versusgroup 1 (50.0%, p=0.0001), group 2 (55.5%, p=0.0001), group 3 (40.0%, p=0.009)]. Moving on cytokines analysis, a negative correlation between daily caffeine consumption and serum level of IFNγ was found (p=0.03, r=-0.2) (figure 2A); furthermore, patients with more caffeine intake showed significant lower levels of IFNα (p=0.02, figure 2B), IL-17 (p=0.01, figure 2C) and IL-6 (p=0.003, figure 2D).Conclusion:This is the first report demonstrating the impact of caffeine on SLE disease activity status, as demonstrated by the inverse correlation between its intake and both SLEDAI-2k values and cytokines levels. Moreover, in our cohort, patients with less caffeine consumption seems to have a more severe disease phenotype, especially in terms of renal and neuropsychiatric involvement. Our results seem to suggest a possible immunoregulatory dose-dependent effect of caffeine, through the modulation of serum cytokine levels, as already suggested byin vitroanalysis.References:[1]Kaul et alNat. Rev. Dis. Prim.2016; 2. Aronsen et alEurop Joul of Pharm2014; 3. Iris et alClin Immun.2018; 4. Gladman et al J Rheumatol. 2002; 5. Mikuls et alArth Rheum2002Disclosure of Interests:Valeria Orefice: None declared, Fulvia Ceccarelli: None declared, cristiana barbati: None declared, Ramona Lucchetti: None declared, Giulio Olivieri: None declared, enrica cipriano: None declared, Francesco Natalucci: None declared, Carlo Perricone: None declared, Francesca Romana Spinelli Grant/research support from: Pfizer, Consultant of: Novartis, Gilead, Lilly, Sanofi, Celgene, Speakers bureau: Lilly, cristiano alessandri Grant/research support from: Pfizer, Guido Valesini: None declared, Fabrizio Conti Speakers bureau: BMS, Lilly, Abbvie, Pfizer, Sanofi

Negative-tone photosensitive polyimides (PSPIs) with a low coefficient of thermal expansion (CTE) were prepared by dissolving polyimide precursor-poly(amide ester) (PAE) resins, photoinitiators, photocrosslinkers and other additives in organic solvents. Using triamine as a monomer and dianhydride and diamine as polycondensates, tri-branched structure PAE resins with different molecular weights named PAE-1~5 were prepared. A series of corresponding PSPI films named PSPI-1~5 were prepared from PAE-1~5 resins with the same formulation, respectively. The PSPI-1~5 films prepared from resins of this structure have excellent mechanical, thermal and electrical properties after being thermally cured at 350 °C/2 h in nitrogen. The PSPI-1~5 films’ coating solution also show good photolithographic performance and are able to obtain photolithographic patterns with a resolution of about 10 μm after homogenization, exposure and development. Among the PSPI-1~5 films, PSPI-2 has the most excellent lithographic properties with a weight average molecular weight (Mw) of 2.9 × 104 g/mol, a CTE of 41 ppk/°C, a glass transition temperature (Tg) of 343 °C and a 5% weight loss temperature (Td5) of 520 °C, making it suitable for industrial scale-up. The mechanical properties of elongation at breakage of 42.4%, tensile moduli of 3.4 GPa and tensile strength of 153.7 MPa were also measured.

Abstract Semarang has experienced floods every year, with a peak in the rainy season. At the end of 2022, there was heavy rain which caused the East Flood Canal River to overflow. As a result, the floods inundated several areas in Semarang City, including Kota Lama of Semarang. This study aims to determine the value of the designed discharge, the area of the flood inundation that occurred and the flood inundation map for return periods of 2, 5, 10, 25, 50 and 100 years. The methodology of this research consist of hydrological analysis, hydrological modelling with HEC-HMS and hydraulics modelling with HEC-RAS and integration with ArcGIS. In this study, it was found that for a return period of 2 years the planned flood discharge value was 153.7 m3/second with an inundation area of 406 Ha and a flood height of 17 cm to 68 cm, up to a return period of 100 years with a planned flood discharge value of 455.7 m3/second with an inundation area of 796 Ha and a flood height of 83 cm to 180 cm.

The small hive beetle (SHB) Aethina tumida Murray, (Coleoptera: Nitidulidae) is now a global invasive pest of honey bees, but its cold tolerance potential has not been yet explored. Therefore, we measured the supercooling point (SCP) of different stages of SHBs and also the impact of acclimation on their SCPs and survival as a measure for cold tolerance. Combinations of different temperatures (0, 3, 5, 7, and 10 ∘C) for different hours (1, 3, 5, 7, 12, 24, 35, and 48 h) were used to assess SHB survival. The supercooling points occurred at lower temperatures (−19.4 ∘C) in wandering larvae than in the other stages (pupae: −12.5 ∘C, and feeding larvae: −10.7 ∘C). A lethal temperature (LT50) of feeding larvae was achieved earlier at 4.9 ∘C after 7 h exposure than the wandering larvae (3.7 ∘C at 48 h) and pupae (5.6 ∘C at 48 h). The sum of injurious temperature (SIT) is the most suitable estimation to describe cold resistance of the SHB immatures. The wandering larvae were the most cold tolerant, followed by pupae and feeding larvae based on SIT values of −286.8, −153.7 and −28.7 DD, respectively, and also showed more phenotypic plasticity after acclimation than feeding larvae and slightly more than pupae. Our results show that all stages, i.e., feeding larvae, wandering larvae and pupae, are chill susceptible. However, these stages, especially wandering larvae and pupae, showed the capacity to acclimate to cold temperatures, which may help them to survive in winter for the continuity of the SHB population, especially in a scenario of climate change.

We measured the impact of pharmaceutical care on outcomes of antihypertensive therapy for patients with elevated baseline blood pressures who were attending an urban university‐affiliated internal medicine clinic. The intervention group received education about hypertension, drug and nondrug management, and assistance to enhance compliance. The pharmacist made recommendations to physicians regarding pharmacotherapy. The control group received no such education, and interventions relating to pharmacotherapy were only physician initiated. Over an average follow‐up of 5 months, significant decreases in mean blood pressures were noted for the intervention group from baseline to final assessment (156.5/144.5 mm Hg systolic, p=0.001; 91.6/86.9 mm Hg diastolic, p=0.01), with insignificant changes in mean pressures in the control group (153.7/151.0 mm Hg systolic, p=0.48; 90.4/87.8 mm Hg diastolic, p=0.29). Comparing the groups, the change in diastolic pressures was insignificant (4.7 vs 2.6 mm Hg intervention vs control, p=0.49), but the change in systolic pressure was more impressive (12.0 vs 2.7 mm Hg, respectively, p=0.05). There was no significant difference in SF‐36 Health Survey scores between groups. A significant decrease (p=0.03) in the SF‐36 physical functioning domain was seen in the intervention group, but no other significant changes in health‐related quality of life scores. Pharmaceutical care contributed to improved blood pressure control in these patients.

BackgroundIron deficiency (ID) has been reported in patients with congenital heart disease. There is, however, a scarcity of data on its prevalence in patients with a Fontan circulation. The aim of this study is to investigate the prevalence of ID in Fontan patients and to investigate the association between ID and exercise capacity in this population.Methods and resultsBlood count and haematological parameters were determined in plasma of 61 Fontan patients (51% female, mean age 29±9 years). ID was defined as transferrin saturation (TSAT) ≤19.8%. The prevalence of ID was 36% (22/61 patients). Especially among women, the diagnosis of ID was highly prevalent (52%) despite normal haemoglobin levels (153.7±18.4 g/L). Mean ferritin levels were 98±80 µg/L and mean TSAT levels were 22%±12%. Cardiopulmonary exercise testing was performed in 46 patients (75%). Patients with ID had a lower peak oxygen uptake (V̇O2peak) (1397±477 vs 1692±530 mL/min; p=0.039), although this relationship was confounded by sex. The presence of ID increased the likelihood of not achieving a respiratory exchange ratio (RER) ≥1.1 by 5-fold (p=0.035).ConclusionID is highly prevalent among patients with a Fontan circulation. V̇O2peak is lower in patients with ID. Fontan patients with ID are less likely to achieve an RER≥1.1 during cardiopulmonary exercise testing.

BackgroundThromboinflammation is a pathological process that is associated with uncontrolled inflammation, leading to hypercoagulability and thrombotic complications. Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are prototypical chronic thromboinflammatory diseases. Neutrophils are important cells in the development of systemic inflammation and thrombosis. Neutrophil reactivity (NEUT-RI), neutrophil granularity (NEUT-GI), immature granulocytes (IG), and neutrophil-to-lymphocyte ratio (NLR) are considered as inflammatory markers.ObjectivesTo determine the role of parameters of neutrophil activation (NEUT-RI, NEUT-GI), immature granulocytes (absolute (IG#), relative (IG%) counts), NLR, ESR in assessing inflammation in SLE, primary APS (PAPS), and SLE with APS.MethodsThe study included 80 patients and 40 healthy donors (HD). Patients were classified into three groups: Group 1 included 37 patients with SLE. The median age of patients with SLE was 34 years [28-43]. Group 2 included 20 patients with SLE+ APS (45 years [37-49]). Group 3 included 23 patients with PAPS (38 years [34,5-47,5]). Current disease activity was evaluated with SLEDAI-2K and adjusted GAPSS (aGAPSS).A complete blood count (WBC-white blood cell, NEUT#-absolute neutrophil count, NEUT-RI, NEUT-GI, IG%, IG count, NLR, thrombocytes, ESR-erythrocyte sedimentation rate) was performed with XN-1000 automated hematology analyzer (Sysmex, Japan).ResultsPatient characteristics are shown in Table 1. IG# and IG% levels were significantly increased in patients with SLE and SLE+APS compared to controls and PAPS. ESR levels was significantly higher in patients with SLE, SLE+APS, and PAPS compared to HD. There was no significant difference between NEUT-RI, NEUT-GI, NLR, fibrinogen and CRP levels in patients with SLE, SLE+APS, PAPS, and HD. The aGAPPS was positively correlated with the IG# (rs=0.46; р=0.028) and IG% levels (rs=0.49; р=0.017) in patients with PAPS. No correlation was found between the IG and SLEDAI 2K. The ESR was positively correlated with SLEDAI 2K in SLE patients (rs =0.54; р≤0.001).Table 1.Characteristics of patients with SLE, PAPS, SLE+APS, and healthy controls.ParametersM±SD, Me [25%; 75%], n (%)SLE (n=37)PAPS (n=23)SLE+APS (n=20)Healthy donors (n=40)pSLEDAI 2K7 [3.5-13]-4 [2-8]-р=0.03*Anti-dsDNA, IU/ml41.6 [13.6-101]-22.2 [10.7-69.9]-NSaCL IgG,n,%2 (5.4)16 (69.5)11 (55.0)-p<0.001*aCL IgM,n,%04 (19)1 (5)-P=0.034*aB2GP1 IgG,n,%2 (5.4)15 (65.2)11 (55.0)-p<0.001*aB2GP1 IgM,n,%1 (2.7)5 (21.7)1 (5)-P=0.053*LA positivity, n,%1 (2.7)15 (65.2)9 (45)-p<0.001*Triple positive,n, %-14 (60.8)7 (35)-NSWBC, 109/l5.1 [3.8-7]5.6 [4.7-6.7]6.4 [4.9-7.7]6.2 [5.3-6.9]NSThrombocytes, 109/l231 [201-300]223.5 [189.5-270]226 [168-278]251 [210-290]NSNEUT#,109/l2.89 [1.84-3.71]3.6 [2.71-4.4]3.3 [3.1-5]3.55 [2.9-4.4]NSNEUT-RI, FI45.5 [43.8-47.3]44.2 [43.1-45.9]45.1 [43.5-47.3]44.0 [42.7-46.2]NSNEUT-GI, SI155.6 [151.6-158.0]154.85 [153.7-156.1]154 [151.2-157.8]153.7 [150.2-155.7]NSNLR1.8 [1.3-2.5]2.1 [1.4-3.1]2.3 [1.6-2,8]1.9 [1.5-2.4]NSESR, mm/h13 [7-20]14 [6.5-18]16 [13-19]7 [4-11]p<0.001*IG#,109/l0.02 [0.01-0.07]0.01 [0.01-0.02]0.03 [0.02-0.05]0.01 [0.01-0.02],p=0.002*IG%0.4 [0.3-1.1]0.2 [0.2-0.4]0.4[0.3-0.7]0.2 [0.2-0.3]p<0.001*CRP, mg/l2.2 [0.6-3.8]1.15 [1-1.4]2.5 [1.7-6.3]-NSFibrinogen, g/l.3.15 [2.8-3.6]3.35 [2.84-3.76]3.21 [2.9-3.8]-NS*a statistically significant test result (p < 0.05); NS-not significant;FI- fluorescence intensity; SI- scatter intensity; fl- femtoliter.ConclusionPatients with SLE and SLE+APS had significantly higher levels of immature granulocytes than controls and PAPS patients. In PAPS, immature granulocytes were positively correlated with aGAPSS values.The study was performed at V.A. Nasonova Research Institute of Rheumatology within the framework of the fundamental research FURS-2022-003.Disclosure of InterestsNone declared

Abstract Introduction Venous thromboembolism (VTE) is associated with a considerable risk for morbidity and recurrence and related hospitalizations. In the Apixaban after the Initial Management of Pulmonary Embolism and Deep Vein Thrombosis with First-Line Therapy-Extended Treatment (AMPLIFY-EXT) trial, a double-blind placebo-controlled trial with 12 months of treatment, two doses of apixaban (2.5 mg and 5 mg, twice daily) versus placebo significantly reduced symptomatic recurrent VTE or all-cause death without increasing the rate of major bleeding among 2,482 VTE patients who had completed 6-12 months of anticoagulation therapy. In this study, the effects of apixaban therapy versus placebo on medical hospitalization during AMPLIFY-EXT trial were evaluated. Methods A total of 2,477 patients who received study drugs were included in the analysis. All-cause hospitalizations during the trial were captured by dedicated case report forms. Outcomes of interest were; rate of hospitalizations and time from randomization to the first hospitalization. Patients were censored at either death, loss to follow-up, or end of study, whichever came first. Effects of treatment with apixaban versus placebo on the rates of hospitalization were assessed using Cox proportional hazards regression models. Results During a mean follow-up of 12.3 months, 138 patients were hospitalized at least once, 62 (7.5%/year) in the placebo group (n=826), 42 (4.8%/year) in the apixaban 2.5 mg group (n=840), and 34 (4.0%/year) in the apixaban 5 mg group (n=811). Compared with placebo, apixaban 2.5 mg [hazard ratio (HR) 0.65, 95% confidence interval (CI) 0.44–0.96; p=0.030] and 5 mg (HR 0.54, 95%CI 0.36–0.83, p=0.004) were both associated with significant reduction in hospitalization. There was no significant difference in hospitalizations between the 2 doses of apixaban (5 mg vs. 2.5 mg: HR 0.84, 95%CI 0.53–1.32, p=0 .445). The mean time to first hospitalization was 153.7 days in the placebo group, 196.9 days in the apixaban 2.5 mg group, and 202.4 days in the apixaban 5 mg group (Figure). Conclusions Extended anticoagulation with apixaban at either a dose of 5 mg or 2.5 mg significantly reduced the risk of hospitalization, possibly due to the reduction in VTE recurrence. Disclosures: Liu: Pfizer: Employment, Equity Ownership. Thompson:Pfizer: Employment, Equity Ownership. Phatak:BMS: Employment, Equity Ownership. Mardekian:Pfizer: Employment, Equity Ownership. Porcari:Pfizer: Employment, Equity Ownership. Johnson:Pfizer: Employment, Equity Ownership.

This study aims to assess the trend, extent, and impact of Human-Elephant conflict (HEC) in Sapahi and Kakadi villages of Bara district. Direct field observation, Household Survey (HHs), Focus Group Discussions (FGDs), and Key Informant Interview (KII) were carried out during November and December 2016 where 11 wards were selected purposively from two village and 50 households from each village. Also, 12 KII and one FGDs from each ward were performed. SPSS 20.0, and MS Excel 2016 were used to calculate mean, percentage, frequency count, and chi-square test was used to determine the variation in people’s perception towards wild Elephant conservation. The total average damage of paddy per year per HHs was 834.1 kg followed by wheat 153.7 kg, and mustard 2.12 kg. The economic value of average annual crop damage per year per HHs accounted for NRs. 22669.70. Among total HHs, 84% of the respondents said that the trend of crop damage is increasing, 10% found no differences in crop damage, and remaining 6% said decreasing. During the last 5 years, 7 people were injured, and 6 were killed. The lighting fire, beating drum, and making noise were the local techniques used by all the respondents to chase away elephant for the mitigation of HEC. The farmers also guard their fields at night time. 60% of the respondents are positive towards elephant conservation and remaining 40% seems no significance for conservation. The compensation scheme for crop damage should be properly implemented in the study area to minimize the HEC. A sustained conservation education program especially focusing on female, farmers, and nomads are recommended to conserve wild elephants, and their habitat.

Background:Promising results from previous studies using cell therapy have paved the way for an innovative treatment option for amyotrophic lateral sclerosis (ALS). There is considerable evidence of immune and inflammatory abnormalities in ALS. Bone marrow mononuclear cells (BMMNCs) possess immunomodulatory properties and could contribute to slowing of disease progression.Objective:Aim of our study was to evaluate the long-term effect of autologous BMMNCs combined with standard treatment on survival duration in a large population and to evaluate effect of type of onset and hormonal status on survival duration in the intervention group.Methods:This controlled, retrospective study spanned over 10 years, 5 months; included 216 patients with probable or definite ALS, 150 in intervention group receiving autologous BMMNCs and standard treatment, and 66 in control group receiving only standard treatment. The estimated survival duration of control group and intervention group was computed and compared using Kaplan Meier analysis. Survival duration of patients with different types of onset and hormonal status was compared within the intervention group.Results:None of the patients reported any major adverse events related to cell administration or the procedure. Kaplan Meier analysis estimated survival duration in the intervention group to be 91.7 months while 49.7 months in the control group (p = 0.008). Within the intervention group, estimated survival was significantly higher (p = 0.013) in patients with limb onset (102.3 months) vs. bulbar onset (49.9 months); premenopausal women (93.1 months) vs. postmenopausal women (57.6 months) (p = 0.002); and preandropausal men (153.7 months) vs. postandropausal males (56.5 months) (p = 0.006).Conclusion:Cell therapy using autologous BMMNCs along with standard treatment offers a promising and safe option for ALS with the potential of long term beneficial effect and increased survival. Limb onset patients, premenopausal women and men ≤ 40 years of age demonstrated better treatment efficacy.

The Gulf Islands National Seashore (GUIS) vegetation inventory project classified and mapped vegetation on park-owned lands within the administrative boundary and estimated thematic map accuracy quantitatively. The project began in June 2016. National Park Service (NPS) Vegetation Mapping Inventory Program provided technical guidance. The overall process included initial planning and scoping, imagery procurement, field data collection, data analysis, imagery interpretation/classification, accuracy assessment (AA), and report writing and database development. Initial planning and scoping meetings took place during May, 2016 in Ocean Springs, Mississippi where representatives gathered from GUIS, the NPS Gulf Coast Inventory and Monitoring Network, and Colorado State University. Primary imagery used for interpretation was 4-band (RGB and CIR) orthoimages from 2014 and 2016 with resolutions of 15 centimeters (cm) (Florida only) and 30 cm. Supplemental imagery with varying coverage across the study area included National Aerial Imagery Program 50 cm imagery for Mississippi (2016) and Florida (2017), 15 and 30 cm true color Digital Earth Model imagery for Mississippi (2016 and 2017), and current and historical true-color Google Earth and Bing Map imagery. National Oceanic Atmospheric Administration National Geodetic Survey 30 cm true color imagery from 2017 (post Hurricane Nate) supported remapping the Mississippi barrier islands after Hurricane Nate. The preliminary vegetation classification included 59 United States National Vegetation Classification (USNVC) associations. Existing vegetation and mapping data combined with vegetation plot data contributed to the final vegetation classification. Quantitative classification using hierarchical clustering and professional expertise was supported by vegetation data collected from 250 plots in 2016 and 29 plots in 2017 and 2018, as well as other observational data. The final vegetation classification includes 39 USNVC associations and 5 park special types; 18 forest and woodland, 7 shrubland, 17 herbaceous, and 2 sparse vegetation types were identified. The final GUIS map consists of 38 map classes. Land cover classes include four types: non-vegetated barren land / borrow pit, developed open space, developed low – high intensity, and water/ocean. Of the 34 vegetation map classes, 26 represent a single USNVC association/park special, six map classes contain two USNVC associations/park specials, and two map classes contain three USNVC associations/park specials. Forest and woodland associations had an abundance of sand pine (Pinus clausa), slash pine (Pinus elliottii), sand live oak (Quercus geminata), yaupon (Ilex vomitoria), wax myrtle (Morella cerifera), and saw palmetto (Serenoa repens). Shrubland associations supported dominant species such as eastern baccharis (Baccharis halimifolia), yaupon (Ilex vomitoria), wax myrtle (Morella cerifera), saw palmetto (Serenoa repens), and sand live oak (Quercus geminata). Herbaceous associations commonly included camphorweed (Heterotheca subaxillaris), needlegrass rush (Juncus roemerianus), bitter seabeach grass (Panicum amarum var. amarum), gulf bluestem (Schizachyrium maritimum), saltmeadow cordgrass (Spartina patens), and sea oats (Uniola paniculata). The final GUIS vegetation map consists of 1,268 polygons totaling 35,769.0 hectares (ha) or 88,387.2 acres (ac). Mean polygon size excluding water is 3.6 ha (8.9 ac). The most abundant land cover class is open water/ocean which accounts for approximately 31,437.7 ha (77,684.2 ac) or 87.9% of the total mapped area. Natural and ruderal vegetation consists of 4,176.8 ha (10,321.1 ac) or 11.6% of the total area. Within the natural and ruderal vegetation types, herbaceous types are the most extensive with 1945.1 ha (4,806.4 ac) or 46.5%, followed by forest and woodland types with 804.9 ha (1,989.0 ac) or 19.3%, sparse vegetation types with 726.9 ha (1,796.1 ac) or 17.4%, and shrubland types with 699.9 ha (1,729.5 ac) or 16.8%. Developed open space, which can include a matrix of roads, parking lots, park-like areas and campgrounds account for 153.8 ha (380.0 ac) or 0.43% of the total mapped area. Artificially non-vegetated barren land is rare and only accounts for 0.74 ha (1.82 ac) or 0.002% of the total area. We collected 701 AA samples to evaluate the thematic accuracy of the vegetation map. Final thematic accuracy, as a simple proportion of correct versus incorrect field calls, is 93.0%. Overall weighted map class accuracy is 93.6%, where the area of each map class was weighted in proportion to the percentage of total park area. This method provides more weight to larger map classes in the park. Each map class had an individual thematic accuracy goal of at least 80%. The hurricane impact area map class was the only class that fell below this target with an accuracy of 73.5%. The vegetation communities impacted by the hurricane are highly dynamic and regenerated quickly following the disturbance event, contributing to map class disagreement during the accuracy assessment phase. No other map classes fell below the 80% accuracy threshold. In addition to the vegetation polygon database and map, several products to support park resource management are provided including the vegetation classification, field key to the associations, local association descriptions, photographic database, project geodatabase, ArcGIS .mxd files for map posters, and aerial imagery acquired for the project. The project geodatabase links the spatial vegetation data layer to vegetation classification, plot photos, project boundary extent, AA points, and the PLOTS database. The geodatabase includes USNVC hierarchy tables allowing for spatial queries of data associated with a vegetation polygon or sample point. All geospatial products are projected using North American Datum 1983 (NAD83) in Universal Transverse Mercator (UTM) Zone 16 N. The final report includes methods and results, contingency tables showing AA results, field forms, species list, and a guide to imagery interpretation. These products provide useful information to assist with management of park resources and inform future management decisions. Use of standard national vegetation classification and mapping protocols facilitates effective resource stewardship by ensuring the compatibility and widespread use throughout the NPS as well as other federal and state agencies. Products support a wide variety of resource assessments, park management and planning needs. Associated information provides a structure for framing and answering critical scientific questions about vegetation communities and their relationship to environmental processes across the landscape.