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Autore: Grafiati

Pubblicato: 25 luglio 2024

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1

Zwanenburg, A., M. A. Abdalah, A. Apte, S. Ashrafinia, J. Beukinga, M. Bogowicz, C. V. Dinh et al. "PO-0981: Results from the Image Biomarker Standardisation Initiative". Radiotherapy and Oncology 127 (aprile 2018): S543—S544. http://dx.doi.org/10.1016/s0167-8140(18)31291-x.

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Ariail, Ellen, e Daniel Hsu. "0981 Complex Sleep Apnea in a Patient with ROHHAD". SLEEP 46, Supplement_1 (1 maggio 2023): A433. http://dx.doi.org/10.1093/sleep/zsad077.0981.

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Abstract Introduction Rapid onset obesity with hypothalamic dysregulation, hypoventilation, and autonomic dysregulation (ROHHAD) is a rare disorder associated with sleep disordered breathing. Patients often have obstructive sleep apnea (OSA) and nocturnal hypoventilation (NH). We present a case with a unique sleep disordered breathing pattern demonstrating both severe central and obstructive sleep apnea demonstrated on two separate polysomnograms with no evidence of significant NH. Report of case(s) The patient is a now 8 year old girl who was initially diagnosed with ROHHAD in October 2020 at age 5 years with symptoms of rapid weight gain, hypothalamic dysfunction (hyperprolactinemia), and autonomic dysfunction (recurrent fever, and hypertension). Diagnostic polysomnography in May 2020 demonstrated severe OSA (oAHI 23.4/hr) as well as central sleep apnea (CAI 63.9/hr). The SaO2 nadir was 88% with 15 minutes spent below 90%. There was no evidence of NH, however the CO2 was greater than 50 mmHg for 9.5% of total sleep time. Subsequent titration study recommended BPAP ST of 14/10 cmH20 with back up rate (BUR) of 12 bpm. The patient had a repeat split night study in May of 2022 at age 7 years. During the diagnostic portion, she demonstrated persistent severe OSA (oAHI 39/hr) and central sleep apnea (CAI 21/hr). There was no evidence of NH with a max TCO2 of 50 mmHg and CO2 > 50 mmHg for 0.2% of total sleep time. BPAP ST of 18/10 cmH20 with BUR of 12 bpm led to resolution of obstructive and central apnea events. Conclusion ROHHAD remains a rare disease which is often associated with sleep disordered breathing. While there have been rare reports of CSA in ROHHAD, there have been none of this severity. CSA may be a representation of autonomic dysfunction, and previous literature has described central pauses in breathing in ROHHAD patients while awake. While she did not have evidence of hypoventilation on either polysomnogram, which is one of the hallmarks of this disease, it has been described that nocturnal hypoventilation may develop later in the course of the disease. Thus, it remains important to routinely screen patients with polysomnograms as their sleep disordered breathing evolves. Support (if any)

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Piefel, K., T. Schneider, S. Söger, S. Gleßmer, O. Bislich, M. H. Seegenschmiedt e F. Fehlauer. "EP-0981 SIMULTANEOUS INTEGRATED BOOST BREAST CANCER – A SUITABLE OPTION?" Radiotherapy and Oncology 103 (maggio 2012): S387—S388. http://dx.doi.org/10.1016/s0167-8140(12)71314-2.

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Zhang, H., e C. Sun. "PO-0981: Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma". Radiotherapy and Oncology 123 (maggio 2017): S542—S543. http://dx.doi.org/10.1016/s0167-8140(17)31417-2.

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5

Dholakia, Swapan, Mary-Margaret Ciavatta e Octavian C. Ioachimescu. "0981 Patient Satisfaction in Veterans Seen in Group Versus Individual Visits". Sleep 42, Supplement_1 (aprile 2019): A395. http://dx.doi.org/10.1093/sleep/zsz067.978.

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TOMANOSKI, V., G. Gjorgjievska, V. Krecova, A. Andonoski, M. Nakovska, K. Ristoska, J. Zvezdakovska, A. Kachakova, S. Kepeska e M. Micajkova Panova. "WCN23-0981 RISK FACTORS FOR COVID-19 MORTALITY IN HEMODIALYSIS PATIENTS". Kidney International Reports 8, n. 3 (marzo 2023): S452. http://dx.doi.org/10.1016/j.ekir.2023.02.1015.

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Rallis, D., F. Yfanti, A. Taliou, S. Kouni, V. Pantelaros, M. Kanariou, I. Orfanou e E. Botsa. "PO-0981 A Novel Mutation Of Ipex Syndrome In A Paediatric Patient". Archives of Disease in Childhood 99, Suppl 2 (ottobre 2014): A571.3—A571. http://dx.doi.org/10.1136/archdischild-2014-307384.1598.

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Nawawi, H., S. Muid, N. S. Osman, R. Annuar, B. A. K. Khalid e K. Yusoff. "4P-0981 Enhanced oxidative stress and endothelial dysfunction in patients with familial hypercholesterolaemia". Atherosclerosis Supplements 4, n. 2 (gennaio 2003): 289–90. http://dx.doi.org/10.1016/s1567-5688(03)91239-6.

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Price, G. "SP-0981 How to design clinical trials which assess the advantage of new technologies". Radiotherapy and Oncology 170 (maggio 2022): S854. http://dx.doi.org/10.1016/s0167-8140(22)04088-9.

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10

Umesh, P., S. Tandon, M. Gairola, P. Ahlawat, S. Purohit e K. Dobriyal. "PO-0981 Wide histological spectrum of sinonasal malignancies and survival outcomes - An Institutional review". Radiotherapy and Oncology 161 (agosto 2021): S814—S816. http://dx.doi.org/10.1016/s0167-8140(21)07432-6.

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11

Silva, Vinicius, Laís Berro, José Galduróz, Sergio Tufik e Monica Andersen. "0981 Gender Has Inversed Roles in a Model Linking Lifetime Substance Use and Sleep". SLEEP 47, Supplement_1 (20 aprile 2024): A421. http://dx.doi.org/10.1093/sleep/zsae067.0981.

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Abstract Introduction The knowledge about the relationship between sleep and substance use constantly undergoes change. Many questions still remain, including how substance use initiation correlates to sleep parameters. In order to expand this body of knowledge, this study aimed at evaluating how lifetime substance use predicts changes in objective and subjective sleep parameters. Methods Volunteers from the EPISONO 2007, a large-scale epidemiological study assessing sleep in a representative sample from the city of São Paulo, Brazil, filled in questionnaires evaluating their general health, and underwent a full-night polysomnographic exam. For this analysis the first question of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST), asking if the individual ever used any of the listed substances, was considered. Age and scores in the Beck Depression and Anxiety Indexes were included as covariates. Gender was also added as an independent variable. Results From the total 1,042 participants, 876(388 men and 488 women) were included. Volunteers reported use of cannabis(n=181), cocaine(n=79), inhalants(n=69), amphetamines(n=54), sedatives(n=31), alcohol(n=802) and tobacco(n=538). Lifetime use of cannabis, cocaine and sedatives directly correlated to alterations in sleep latency, REM sleep onset latency, sleep efficiency and scores in the Epworth Sleepiness Scale. Gender significantly interacted with substance use, with women who consumed cocaine and cannabis and men who never did presenting increased total sleep time when compared to their counterpart groups (men who ever consumed these substances and women who never did). Conclusion We found not only an effect of the lifetime consumption of popular drugs, such as cocaine and cannabis, but also identified an important role for gender, which seems to have inversed roles in males and females. These results provide an intriguing lead to unravelling a network in which gender, sleep and substance use are present, and advances in this area will be a major step in the investigation of the importance of sleep in the psychopharmacology scenario. Support (if any) Our studies are supported by grants from the Associacão Fundo de Incentivo à Pesquisa (AFIP) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP – grant #2020/13467-8 to MLA). MLA is a Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) fellowship recipient.

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Leonardi, M. C., F. Cattani, M. Pepa, R. Luraschi, S. Vigorito, S. G. Gugliandolo, D. Ciardo, R. Orecchia e B. A. Jereczek-Fossa. "PO-0981: Variability of axillary nodal CTV contouring in breast cancer (PART II – dosimetric impact)". Radiotherapy and Oncology 152 (novembre 2020): S523. http://dx.doi.org/10.1016/s0167-8140(21)00999-3.

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13

Daniel, L. C., Y. Gross, L. Meltzer, C. Forrest e L. Barakat. "0981 Sleep Practices In Pediatric Cancer—Does Sleep Hygiene Matter For Reducing Cancer Symptom Burden?" Sleep 43, Supplement_1 (aprile 2020): A372—A373. http://dx.doi.org/10.1093/sleep/zsaa056.977.

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Abstract Introduction Sleep disturbances are common during pediatric cancer treatment and recent evidence suggests a correlation between sleep and symptom burden. Improving nighttime sleep may impact patients’ ability to cope with symptoms. The current study tests the interaction between sleep hygiene and sleep disturbances in predicting cancer-related symptoms to determine if the relationship between sleep and symptoms is different for patients with better sleep hygiene. Methods 102 caregivers of children with cancer (ages 5-17, M=10.12, SD=4.02; 58% female) completed parent-proxy Pediatric Sleep Practices Questionnaire (yielding routine consistency and sleep opportunity scores) and measures of cancer-related symptoms (PROMIS Sleep Disturbance, Fatigue, and Pain Interference; PedsQL—Cancer Module-Nausea subscale). The interaction between sleep disturbances and sleep hygiene (consistency, opportunity) on each symptom (pain, nausea, fatigue) were tested using PROCESS moderation. Results 81% of caregivers report that their child receives sufficient sleep but only 12% reported regular consistent sleep patterns/routines. Sleep opportunity was not related to sleep disturbances or cancer-related symptoms, but more routine consistency was related to fewer sleep disturbances (r=.30, p=.003). The interaction between sleep disturbances and routine consistency significantly predicted pain interference [R2=.16, F(3, 98)=6.37, p<.001; Bint =-0.17, p=.028] and nausea [R2=.16, F(3, 98)=6.47, p<.001; Bint=0.46, p=.004]. The interaction between sleep disturbances and sleep opportunity significantly predicted nausea [R2=.15, F(3, 98)=5.76, p=.001; Bint =0.68, p=.016] but not pain interference. Both interaction models predicting fatigue were not significant. Conclusion The sleep/pain and sleep/nausea relationships are stronger in patients with more consistent sleep routines and the sleep/nausea relationship is also stronger in patients with sufficient/well-timed sleep opportunities. Sleep and fatigue were moderately related across all levels of both sleep hygiene components. Clinical interventions that target sleep hygiene together with sleep disturbances such as nighttime awakenings and poor sleep quality may be more effective in addressing cancer-related symptoms such as pain and nausea. Support This work was supported in part by funding from the Patient-Centered Outcomes Research Institute (PCORI-D-17-00187; PI Christopher Forrest).

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Shankar, A., J. Kesavadev, G. Krishnan, R. Jose, A. Basanth e S. Jothydev. "IDF2022-0981 Fibroscan as an easy to use tool in predicting NAFLD progression in diabetes". Diabetes Research and Clinical Practice 197 (marzo 2023): 110492. http://dx.doi.org/10.1016/j.diabres.2023.110492.

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Huang, Alexander C. Y., Sandip Mondal, Sharmistha Chatterjee Sriwastav, Natalia Giza e Yoshiko Kawachi. "Book Reviews". Multicultural Shakespeare: Translation, Appropriation and Performance 9, n. 24 (28 dicembre 2012): 71–90. http://dx.doi.org/10.2478/v10224-011-0017-2.

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Diana E Henderson, Collaborations with the Past: Reshaping Shakespeare across Time and Media, Ithaca: Cornell University Press, 2006. Pp. xi + 289. ISBN 978-0801444197. Vintage Shakespeare: New Perspectives From India and Abroad, eds. Prashant K. Sinha and Mohini Khot, Jaipur: Book Enclave, 2010. Pp. 240. ISBN 978-81-8152-271-9. The Tempest by William Shakespeare, ed. Sarbani Chaudhury, New Delhi: Pearson Longman, 2009. Pp. Liii +217. ISBN 978-81-317-0981-8. Elżbieta Stanisz, Kierunki Polskiej Szekspirologicznej Myśli Krytycznej w Dwudziestoleciu Miedzywojennym (1918-1939) [Shakespearean Criticism in Poland in the Inter-War Period], Toruń: Wydawnictwo Adam Marszałek, 2011. Pp. 290. ISBN 978-83-7611-887-1. Shakespeare: The Indian Icon, ed. Vikram Chopra, New Delhi: The Readers Paradise, 2011. Pp. xxvi + 836. ISBN 978-81-920751-2-9

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Dersjant-Li, Y., e G. Dusel. "0981 Effect of increasing Buttiauxella phytase dose to 2000 FTU/kg on phytate degradation and ileal AA digestibility in weaned pigs". Journal of Animal Science 94, suppl_5 (1 ottobre 2016): 471. http://dx.doi.org/10.2527/jam2016-0981.

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Saez, J., A. Varo Curbelo, N. Anducas e S. Madirolas. "PO-0981: Virtual detection of collisions between patient and gantry in tangential fields in breast radiotherapy". Radiotherapy and Oncology 111 (2014): S138. http://dx.doi.org/10.1016/s0167-8140(15)31099-9.

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Pignolo, L., S. Rogano, M. Quintieri, E. Leto e G. Dolce. "Decreasing incidence of paroxysmal sympathetic hyperactivity syndrome in the vegetative state". Journal of Rehabilitation Medicine 44, n. 6 (2012): 502–4. http://dx.doi.org/10.2340/16501977-0981.

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Johansson, U., I. Rasmusson, S. P. Niclou, N. Forslund, L. Gustavsson, B. Nilsson, O. Korsgren e P. U. Magnusson. "Formation of Composite Endothelial Cell-Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization". Diabetes 57, n. 9 (2 giugno 2008): 2393–401. http://dx.doi.org/10.2337/db07-0981.

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Lindroos, M. M., K. Majamaa, A. Tura, A. Mari, K. K. Kalliokoski, M. T. Taittonen, P. Iozzo e P. Nuutila. "m.3243A>G Mutation in Mitochondrial DNA Leads to Decreased Insulin Sensitivity in Skeletal Muscle and to Progressive -Cell Dysfunction". Diabetes 58, n. 3 (10 dicembre 2008): 543–49. http://dx.doi.org/10.2337/db08-0981.

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Allister, E. M., C. A. Robson-Doucette, K. J. Prentice, A. B. Hardy, S. Sultan, H. Y. Gaisano, D. Kong et al. "UCP2 Regulates the Glucagon Response to Fasting and Starvation". Diabetes 62, n. 5 (22 febbraio 2013): 1623–33. http://dx.doi.org/10.2337/db12-0981.

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Miller, J. J., T. Curtis, D. S. Chanasyk e W. D. Willms. "Influence of streambank fencing and river access for cattle on riparian zone soils adjacent to the Lower Little Bow River in southern Alberta, Canada". Canadian Journal of Soil Science 94, n. 2 (maggio 2014): 209–22. http://dx.doi.org/10.4141/cjss2013-0981.

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Miller, J. J., Curtis, T., Chanasyk, D. S. and Willms, W. D. 2014. Influence of streambank fencing and river access for cattle on riparian zone soils adjacent to the Lower Little Bow River in southern Alberta, Canada. Can. J. Soil Sci. 94: 209–222. Cattle grazing in riparian pastures adjacent to rivers may increase soil compaction and increase soil nutrients, such as N and P. We conducted a 4-yr study with sampling in 3 yr (2009, 2010, 2012) of riparian zone soils adjacent to fenced and unfenced reaches of the Lower Little Bow River in southern Alberta. We examined the effect of grazing, access of cattle to the river (access versus no-access), and distance (0.25, 1, 2, 4, 6, 8, 10 m) from the river on surface soil bulk density, volumetric water content, NH4-N, NO3, and soil test P. Penetration depth was also measured in 2012. The three grazing treatments consisted of one fenced reach (ungrazed treatment), one unfenced and grazed reach with high cattle impact (high-impact grazed treatment), and one unfenced and grazed reach with low cattle impact (low-impact grazed treatment). We hypothesized that soil compaction would be greater, soil nutrients would be enriched, and soil water content would be lower for grazed compared with ungrazed treatments, and that this same trend would occur for access compared with no-access locations. The soil properties in our study were generally significantly (P≤0.05) influenced by grazing, access, and distance from the riverbank. However, treatment effects were generally dependent on two- or three-way interactions with the other factors. Soil bulk density in 2009 and 2012 was 8 to 20% greater at access compared with no-access locations within 2 m of the riverbank, suggesting soil compaction by cattle was confined close to the wetter riverbank soils. Most soil properties generally supported our hypothesis of greater soil compaction and nutrient enrichment for unfenced compared with fenced reaches, as well as for access compared with no-access locations. The exceptions were soil water content and soil test P results that did not support the grazing hypothesis, and soil water content and NH4-N results that did not support the cattle-access hypothesis.

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Mogensen, M., K. Sahlin, M. Fernstrom, D. Glintborg, B. F. Vind, H. Beck-Nielsen e K. Hojlund. "Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes". Diabetes 56, n. 6 (9 marzo 2007): 1592–99. http://dx.doi.org/10.2337/db06-0981.

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Sofi, M. H., R. Gudi, S. Karumuthil-Melethil, N. Perez, B. M. Johnson e C. Vasu. "pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence". Diabetes 63, n. 2 (5 novembre 2013): 632–44. http://dx.doi.org/10.2337/db13-0981.

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Fidler, Trevor P., Alex Marti, Katelyn Gerth, Elizabeth A. Middleton, Robert A. Campbell, Matthew T. Rondina, Andrew S. Weyrich e E. Dale Abel. "Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes". Diabetes 68, n. 5 (14 febbraio 2019): 932–38. http://dx.doi.org/10.2337/db18-0981.

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Nguyen, Q. M., e G. S. Berenson. "Utility of Childhood Glucose Homeostasis Variables in Predicting Adult Diabetes and Related Cardiometabolic Risk Factors: The Bogalusa Heart Study: Response to d'Annunzio, Russo, and Lorini". Diabetes Care 33, n. 9 (30 agosto 2010): e124-e124. http://dx.doi.org/10.2337/dc10-0981.

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Sosenko, Jay M., Jay S. Skyler, Jerry P. Palmer, Jeffrey P. Krischer, David Cuthbertson, Liping Yu, Desmond A. Schatz, Tihamer Orban e George Eisenbarth. "A Longitudinal Study of GAD65 and ICA512 Autoantibodies During the Progression to Type 1 Diabetes in Diabetes Prevention Trial–Type 1 (DPT-1) Participants: Figure 1". Diabetes Care 34, n. 11 (12 settembre 2011): 2435–37. http://dx.doi.org/10.2337/dc11-0981.

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Maejima, H., R. Tanei, T. Morioka e S. Miyakoshi. "Haemophagocytosis-related Intravascular Large B-cell Lymphoma Associated with Skin Eruption". Acta Dermato Venereologica 91, n. 3 (2011): 339–40. http://dx.doi.org/10.2340/00015555-0981.

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Baranskaya, Aliaksandra, Yimeng Zhang e Brian Lee. "Thyrotoxic Periodic Paralysis: A Case Report with Patient Perspective". Acute Medicine Journal 23, n. 2 (1 aprile 2024): 91–94. http://dx.doi.org/10.52964/amja.0981.

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We present a case report on a spot diagnosis of Thyrotoxic Periodic Paralysis (TPP) with a unique first-person account of events from the patient. It illustrates the importance of pattern recognition and exemplifies how timely treatment enables quick resolution of a life-threatening medical emergency. Patient X’s account affirms the condition’s insidious onset and rapid deterioration. This case highlights the need for raising awareness of diseases that are more prevalent in specific ethnic groups and is particularly crucial for work in culturally diverse environments. We hope by sharing our experience, readers will be prompted to consider TPP as a differential diagnosis for acute limb weakness in an acute setting; with prompt testing of thyroid function and initiation of the appropriate treatments.

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Hallahan, D., V. Kapoor, D. Thotala e H. Yan. "PO-0981: Activation of immune cells and enhanced efficacy of radiotherapy by anti-TIP1 antibodies in cancer". Radiotherapy and Oncology 119 (aprile 2016): S477. http://dx.doi.org/10.1016/s0167-8140(16)32231-9.

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Finazzi, T., M. Palacios, F. Spoelstra, C. Haasbeek, A. Bruynzeel, B. Slotman, F. Lagerwaard e S. Senan. "PO-0981 Role of on-table plan adaptation in MRguided ablative radiation therapy for central lung tumors". Radiotherapy and Oncology 133 (aprile 2019): S536—S537. http://dx.doi.org/10.1016/s0167-8140(19)31401-x.

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Gunter, R., E. Szeto, S. Suh, K. Park, J. Lee, R. Lee, Y. Kim e A. Waters. "0981 Associations between Sleep Worry, Affect and Smoking in South Korean Smokers: An Ecological Momentary Assessment study". Sleep 41, suppl_1 (aprile 2018): A364. http://dx.doi.org/10.1093/sleep/zsy061.980.

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Withers, D., É. Isaacs, R. Fullarton, E. Almond e M. Ulewich. "PD-0981 Use of RapidPlan knowledge-based planning models for planning of rectum cases with Ethos TPS". Radiotherapy and Oncology 182 (maggio 2023): S829. http://dx.doi.org/10.1016/s0167-8140(23)09054-0.

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Huang, B., J. Lu, P. Lin e C. Chen. "PO-0981: Optimizing the planning parameters to obtain the lowest monitor units in lung stereotactic body radiation therapy". Radiotherapy and Oncology 115 (aprile 2015): S522—S523. http://dx.doi.org/10.1016/s0167-8140(15)40973-9.

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BIRD, BENJAMIN. "Peter Boxall, Don DeLillo: The Possibility of Fiction (London: Routledge, 2006, £65.00). Pp. 252. ISBN 0 4153 0981 6." Journal of American Studies 41, n. 1 (8 marzo 2007): 198–99. http://dx.doi.org/10.1017/s0021875806273456.

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Polat, B., M. Parczyk, S. Aeffner, M. Metz, G. Beckmann, O. Sauer, M. Guckenberger e M. Flentje. "PO-0981: First experiences with combined EBRT and HDR-brachytherapy boost using Co-60 in patients with prostate cancer". Radiotherapy and Oncology 106 (marzo 2013): S378. http://dx.doi.org/10.1016/s0167-8140(15)33287-4.

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Marganne, Marie-Hélène. "John F Nunn, Ancient Egyptian medicine, London, British Museum Press, 1996, pp. 240, illus., £25.00 (0-7141-0981-9)." Medical History 41, n. 3 (luglio 1997): 410–11. http://dx.doi.org/10.1017/s0025727300062967.

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Berinstein, Neil, Isabelle Bence-Bruckler, Nick Forward, Pierre Laneuville, Joy Mangel, Douglas Stewart, Irina Amitai et al. "356 Baseline PD-L1 expression and tumor immune infiltration is associated with clinical response in patients with r/r DLBCL treated with DPX-Survivac, low-dose cyclophosphamide and pembrolizumab". Journal for ImmunoTherapy of Cancer 8, Suppl 3 (novembre 2020): A381. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0356.

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BackgroundTreatment of recurrent/refractory (r/r) DLBCL remains an unmet clinical need, and new effective and well-tolerated treatments are required. DPX-Survivac is a unique T cell activation therapy that targets survivin-expressing tumor cells and has shown anti-tumor activity in clinical trials. This trial is evaluating a novel immunotherapy combination with DPX-Survivac, intermittent low dose CPA and pembrolizumab.Methods‘SPiReL’ is a Phase 2 non-randomized, open label, efficacy and safety study of a novel immunotherapy combination with DPX-Survivac (a unique T cell activation therapy that targets survivin-expressing tumor cells), intermittent low dose CPA and pembrolizumab, treatment regimen as described in figure 1. Subjects with r/r incurable DLBCL and survivin expression are eligible for participation. This study was approved by the Ontario Cancer Research Ethics Board, approval number 0981.ORR is assessed by modified Cheson criteria. For translational analyses, baseline and on-treatment PBMCs, along with tumor biopsy samples are collected from each subject. Survivin-specific systemic T cell responses are assessed using IFNγ-ELISPOT assay and tumour immune-infiltrate profile by multiplex-IHC.ResultsTwenty-two subjects have been enrolled to date, 19 are included in the intent to treat (ITT) population and 11 subjects are evaluable in the per protocol (PP) population. In the PP, the ORR is 63.6% including 3 CRs (27.3%), 4 PRs (36.4%) and the DCR is 81.8% (9/11). In the ITT, the ORR is 35% (7/19), and DCR is 52.0% (10/19). Preliminary results show that non-GCB subjects had a higher proportion of clinical response (4/8, 50%), compared to 3/10 (30%) in GCB subjects.DPX-Survivac-induced T cell responses were observed in 8/19 subjects (42.1%) including 6 subjects with clinical response (PR, CR), one SD and one PD. Multiplex-IHC analyses demonstrated baseline tumor PD-L1 expression in 6/7 subjects with a clinical response (85.7%, p<0.05). Similarly, subjects with higher baseline CD4+ and CD8+ T cell infiltration demonstrated a trend towards clinical response (table 1).Abstract 356 Figure 1SPiReL treatment regimenAbstract 356 Table 1Data summary of resultsConclusionsDPX-Survivac, intermittent low-dose CPA and pembrolizumab is generally well tolerated and can induce clinical responses in subjects with r/r DLBCL (7/11, 63.6% of evaluable subjects), including subjects with both non-GCB and GCB subtypes. Pre-treatment biopsies of clinical responders were characterized by higher baseline tumor PD-L1 expression and CD4 and CD8 infiltration. Extending this exploratory data in a larger cohort may define a r/r DLBCL patient population with a higher likelihood to respond to this novel combination immunotherapy.Trial RegistrationNCT03349450Ethics ApprovalThis study was approved by the Ontario Cancer Research Ethics Board, approval number 0981.

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Ergün, G., e G. Ozaltin. "EPA-0981 – Evaluation of efficiency of giving counselling in the post-operation adaptation process of individuals who had kidney patients". European Psychiatry 29 (2014): 1. http://dx.doi.org/10.1016/s0924-9338(14)78282-3.

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Hsu, HC, e SY Lee. "0981 SLEEP AND PSYCHOLOGICAL DISTRESS: A CROSS-CULTURAL ANALYSIS COMPARING AMERICAN AND TAIWANESE MOTHERS OF LOW-BIRTH WEIGHT PRETERM INFANTS". Sleep 40, suppl_1 (28 aprile 2017): A364. http://dx.doi.org/10.1093/sleepj/zsx050.980.

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Collareta, Alberto, Walter Landini, Giovanni Bianucci e Claudio Di Celma. "Until Panama do us part: new finds from the Pliocene of Ecuador provide insights into the origin and palaeobiogeographic history of the extant requiem sharks Carcharhinus acronotus and Nasolamia velox". Neues Jahrbuch für Geologie und Paläontologie - Abhandlungen 300, n. 1 (29 aprile 2021): 103–15. http://dx.doi.org/10.1127/njgpa/2021/0981.

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Liss, Linus. "Ersteinschätzung ohne Hilfsmittel – Schritt für Schritt". retten! 10, n. 01 (febbraio 2021): 66–68. http://dx.doi.org/10.1055/a-0981-1763.

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Abhijit e Jeffrey Naber. "Ionization Signal Response during Combustion Knock and Comparison to Cylinder Pressure for SI Engines". SAE International Journal of Passenger Cars - Electronic and Electrical Systems 1, n. 1 (14 aprile 2008): 349–64. http://dx.doi.org/10.4271/2008-01-0981.

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Eventov-Friedman, S., H. Kanevsky e B. Bar-Oz. "Neonatal End-of-Life Care: A Single-Center NICU Experience in Israel Over a Decade". PEDIATRICS 131, n. 6 (13 maggio 2013): e1889-e1896. http://dx.doi.org/10.1542/peds.2012-0981.

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Böttcher, Arnd, Horst Elias, Jørgen Glerup, Markus Neuburger, Carl Erik Olsen, Johan Springborg, Høgni Weihe, Margareta Zehnder e George W. Francis. "Synthesis, Structure and Magnetic Properties of Mono- and Dinuclear Chromium(III) Complexes with Tetrahydrosalen and Substituted Tetrahydrosalen Derivatives as Ligands. Crystal Structure of a Phenoxo-Bridged Dichromium(III) Complex." Acta Chemica Scandinavica 48 (1994): 981–88. http://dx.doi.org/10.3891/acta.chem.scand.48-0981.

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Døssing, Anders, Olov Karlsson, Knut Lundquist, Rolf Stomberg, Elemér Fogassy, Charles A. McAuliffe, Stenbjörn Styring, Cecilia Tommos, Kurt Warncke e Bryan R. Wood. "Luminescence Properties of the Europium(III) Complex of the Octadentate Polypyridyl Ligand 1,1'-bis[bis(2-pyridylmethyl)aminomethyl]-3,3'-biisoquinoline." Acta Chemica Scandinavica 51 (1997): 981–83. http://dx.doi.org/10.3891/acta.chem.scand.51-0981.

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Hall-Mendelin, Sonja, Doris Genge, Glen R. Hewitson, Andrew F. van den Hurk, Alyssa T. Pyke, Amanda J. De Jong e Peter J. Burtonclay. "FTA Cards Facilitate Storage, Shipment, and Detection of Arboviruses in Infected Aedes aegypti Collected in Adult Mosquito Traps". American Journal of Tropical Medicine and Hygiene 96, n. 5 (3 maggio 2017): 1241–43. http://dx.doi.org/10.4269/ajtmh.16-0981.

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Allou, Nicolas, Romain Persichini, Nicolas Traversier, Dorothée Valance, Caroline Brulliard, Sandrine Picot, Olivier Martinet, Aurélien Soubeyrand, Olivier Belmonte e Jérôme Allyn. "Waterborne Infections in Reunion Island, 2010–2017". American Journal of Tropical Medicine and Hygiene 99, n. 3 (5 settembre 2018): 578–83. http://dx.doi.org/10.4269/ajtmh.17-0981.

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Wiggans, G. R., J. B. Cole e L. L. M. Thornton. "Multiparity Evaluation of Calving Ease and Stillbirth with Separate Genetic Effects by Parity". Journal of Dairy Science 91, n. 8 (agosto 2008): 3173–78. http://dx.doi.org/10.3168/jds.2007-0981.

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Egger, Marion, e Chiara Höhler. "„Mobilität ist Freiheit“ – Patient*innen erzählen". physiopraxis 20, n. 07/08 (luglio 2022): 32–37. http://dx.doi.org/10.1055/a-1881-0981.

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