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Letteratura scientifica selezionata sul tema "004.02 : 004.4"

Autore: Grafiati
Pubblicato: 30 maggio 2022
Ultima modifica: 31 maggio 2022

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Articoli di riviste sul tema "004.02 : 004.4"

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Burmistrova, A. L., M. N. Vavilov, D. S. Stashkevich e T. A. Suslova. "Immunogenetic profile of MIC (A, B) HLA loci linked to MHC antigenic complex in Russians of the Chelyabinsk Region". Medical Immunology (Russia) 24, n. 1 (10 marzo 2022): 41–52. http://dx.doi.org/10.15789/1563-0625-ipo-2324.

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Abstract (sommario):
The MIC genes are located on chromosome 6 in the class I major histocompatibility complex (MHC) region and encode a membrane-bound stress-inducible protein that acts as a ligand to stimulate the NKG2D activating receptor expressed on the surface of the most natural killer cells (NK). Currently, 7 MIC loci are known, of which only MICA and MICB encode proteins and show a significant allelic polymorphism. The MIC gene polymorphism and their location in the HLA region suggests presence of some ethnic and populational differences for the gene frequencies, linkage disequilibrium of distinct loci, and distribution of HLA-MIC haplotypes, thus making it possible to get information on genetic relationship of human populations. The aim of our study was to assess immunogenetic profile of Russian population in Chelyabinsk Region based on the non-classical HLA loci, i.e., MICA and MICB, in the context of worldwide population data. Methods of the study included immunogenetic typing of 100 donors identifying themselves as Russians, taken from the Registry of Stem Cell Donors at the Chelyabinsk Regional Blood Transfusion Station. The 2 loci (MICA and MICB) were typed at basic resolution, using PCR technique with sequence-specific primers (SSP-PCR). Gene frequencies (GF) were calculated using programs for immunogenetic research (Arlequin 3.5).Among Russian population from Chelyabinsk Region, the following characteristics of the MICA gene distributions were found: MICA *008, *002, *010, *009, frequency of > 7%; average frequencies, for MICA *004, *007, *018, *017; whereas MICA *027, *011, *006, *009:02, *049, *012, *016 was registered at a frequency of < 3.5%. MICB gene profile was as follows: MICB *005:02, *004, *002, *008 at a frequency of > 6%; at a frequency of 4% MICB *003, *005:03; MICB *005:01, * 005:04, * 009N, MICB *013, *014 at a frequency of0.5%. As based on calculated genetic distances (according to Ney) for the MICA locus, the dendrogram and scatter plot were designed by means of multidimensional scaling (MDS) method, presenting location of 30 world populations, including data on Russians in Chelyabinsk Region. The smallest genetic distances between the population of Russians from Chelyabinsk Region and other world populations were found between the population of Slovenia, as well as the USA population of European origin. As based on scatterplot obtained by the MDS approach for MICA gene frequencies, using the data of cluster analysis, we have found that the population of Russians from Chelyabinsk Region belongs to a cluster of typical European populations.The obtained patterns could be used for practical purposes to create a registry of stem cell donors in Russia. In addition, the data may be used as a control group for further research in the area of HLA-disease association, and could be also demanded by the specialists in population ethnogenesis.
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Tsimberidou, A. M., C. Tam, W. Wierda, S. O' Brien, S. Lerner e M. J. Keating. "Beta-2 microglobulin (B2M) is an independent prognostic factor for clinical outcomes in patients with CLL treated with frontline fludarabine, cyclophosphamide, and rituximab (FCR) regardless of age, creatinine clearance (CrCl)". Journal of Clinical Oncology 25, n. 18_suppl (20 giugno 2007): 7034. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.7034.

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Abstract (sommario):
7034 Introduction: High β2M levels are a risk factor in CLL. PCR therapy has been reported to be better tolerated than FCR in older or with decrease renal function pts (Shanafelt, Blood 108:15a). We assessed the association between age, CrCl, PS, β2M and outcomes in pts treated with FCR. Methods: From 7/99 to 1/04, 300 pts received rituximab 375 mg/m2 D1; fludarabine 25 mg/m2/d D2–3; and cyclophosphamide 250 mg/m2/d D2–3. Serum β2M levels were measured by radioimmunoassay. CrCl was calculated (Cockcroft-Gault equation). Results: The median age was 57 yrs (≥70, 14%). Age ≥70 was associated with fewer FCR courses (p<.0001); lower rates of CR (p=.001), overall response (OR; p=.04), survival (OS; p<.0001), and FFS (p=.008); and higher rates of G3–4 thrombopenia (p<.0001) or anemia (p=.002) compared with age<70. The median CrCl was 90 mL/min (CrCl <70, 27%). Pts with CrCl <70 had higher rates of G3–4 thrombopenia (p=.006) or anemia (p=.01) than others. There were no differences between the 2 groups in the other outcomes. PS was 0 in 40%, 1 in 57%, and 2 in 3% of pts. Better PS was associated with higher rates of CR (p=.007) and FFS (p=.02) but did not affect OR or OS. The median β2M level was 3.7 mg/L (β2M ≥ 4, 43%). The rates of CR, survival, and FFS were lower in pts with β2M ≥ 4 compared with others (p<.0001 each). High β2M levels were associated with older age, lower CrCl levels, poorer PS (p<.0001 each), higher rates of G3–4 neutropenia (p=.005), thrombocytopenia (p=.01), and infections (p=.03), and fewer FCR courses (p=.004). The median follow-up was 5 yrs. The rates of CR, 3-yr OS and 3-yr FFS were 72%, 87% and 76%, respectively. Independent factors predicting response were lower β2M (p=.0004) and lower WBC counts (p=.02). Independent factors predicting longer OS were younger age (p=.001), lower β2M (p=.003) and lower WBC (p=.03). Independent factors predicting longer FFS were lower β2M levels (p=.0006), and lower WBC counts (p=.005). Conclusion: Age ≥70 yrs and poor PS, but not CrCl level were associated with poor clinical outcomes. High β2M levels are an independent adverse prognostic factor for CR, OS, and FFS in the context of other prognostic factors. No significant financial relationships to disclose.
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Beltrame, André B., e Sérgio Florentino Pascholati. "Cianobactérias e algas reduzem os sintomas causados por Tobacco vosaic virus (tmv) em plantas de fumo". Summa Phytopathologica 37, n. 2 (giugno 2011): 140–45. http://dx.doi.org/10.1590/s0100-54052011000200010.

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Abstract (sommario):
As algas e as cianobactérias produzem uma grande diversidade de compostos com atividade biológica direta sobre microrganismos ou agem como ativadores de mecanismos de resistência em plantas. Em vista disso, foi investigada a manifestação dos sintomas causados pelo Tobacco mosaic virus (TMV) em plantas de fumo previamente tratadas com cianobactérias ou algas. Quando as folhas plantas de fumo foram tratadas dois dias antes da inoculação, foi verificado que suspensões de células dos isolados de cianobactérias 004/02, 008/02, Anabaena sp. e Nostoc sp. 61; e do isolado de alga 061/02, bem como as preparações do conteúdo intracelular do isolado 004/02 (4 C) e do filtrado do meio de cultivo do isolado 061/02 (61 M) apresentaram efeito na redução do número de lesões locais provocadas por TMV em folhas de plantas fumo, cultivar TNN. Além disso, foi observado que os isolados Anabaena sp., Nostoc sp. 21 (cianobactéria), Nostoc sp. 61 e 090/02 (alga) mostraram efeito direto sobre o vírus semi-purificado. Em vista disso, pode-se sugerir que os isolados estudados sintetizam compostos que agem diretamente sobre o TMV e/ou ativam o mecanismo de defesa de plantas contra fitopatógenos.
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Finkenstedt, Gerd, Rudolf W. Gasser, Günter Höfle, Christine Watfah e Leo Fridrich. "Effects of growth hormone (GH) replacement on bone metabolism and mineral density in adult onset of GH deficiency: results of a double-blind placebo-controlled study with open follow-up". European Journal of Endocrinology 136, n. 3 (marzo 1997): 282–89. http://dx.doi.org/10.1530/eje.0.1360282.

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Abstract (sommario):
Abstract It is known that GH stimulates bone turnover and that GH-deficient adults have a lower bone mass than healthy controls. In order to evaluate the influences of GH replacement therapy on markers of bone turnover and on bone mineral density (BMD) in patients with adult onset GH deficiency, a doubleblind placebo-controlled study of treatment with recombinant human GH (rhGH; mean dose 2·4 IU daily) in 20 patients for 6 months and an extended open study of 6 to 12 months were conducted. Eighteen patients, fourteen men and four women, with a mean age of 44 years with adult onset GH deficiency were evaluated in the study. Compared with placebo, after 6 months serum calcium (2·39±0·02 vs 2·32±0·02 mmol/l, P=0·037) and phosphate (0·97±0·06 vs 0·75±0·05 mmol/l, P=0·011) increased and the index of phosphate excretion (0·03±0·03 vs 0·19±0·02, P<0·001) decreased significantly, and there was a significant increase in the markers of bone formation (osteocalcin, 64·8±11·8 vs 17·4±1·8 ng/ml, P<0·001; procollagen type I carboxyterminal propeptide (PICP), 195·3±26·4 vs 124·0±15·5 ng/ml, P=0·026) as well as those of bone resorption (type I collagen carboxyterminal telopeptide (ICTP), 8·9±1·2 vs 3·3±0·5 ng/ml, P<0·001; urinary hydroxyproline, 0·035±0·006 vs 0·018±0·002 mg/100 ml glomerular filtration rate, P=0·009). BMD did not change during this period of time. IGF-I was significantly higher in treated patients (306·5±45·3 vs 88·7±22·5 ng/ml, P<0·001). An analysis of the data compiled from 18 patients treated with rhGH for 12 months revealed similar significant increases in serum calcium and phosphate, and the markers of bone turnover (osteocalcin, PICP, ICTP, urinary hydroxyproline). Dual energy x-ray absorptiometry (DXA)-measured BMD in the lumbar spine (1·194±0·058 vs 1·133±0·046 g/cm2, P=0·015), femoral neck (1·009±0·051 vs 0·936±0·034 g/cm2, P=0·004), Ward's triangle (0·801±0·055 vs 0·816±0·04 g/cm2, P=0·019) and the trochanteric region (0·869±0·046 vs 0·801±0·033 g/cm2, P=0·005) increased significantly linearly (compared with the individual baseline values). At 12 months, BMD in patients with low bone mass (T-score < −1·0 s.d.) increased more than in those with normal bone mass (lumbar spine 11·5 vs 2·1%, P=0·030, and femoral neck 9·7 vs 4·2%, P=0·055). IGF-I increased significantly in all treated patients. In conclusion, treatment of GH-deficient adults with rhGH increases bone turnover for at least 12 months. BMD in the lumbar spine and the proximal femur increases continuously in this time (open study) and the benefit is greater in patients with low bone mass. Therefore, GH-deficient patients exhibiting osteopenia or osteoporosis should be considered candidates for GH supplementation. However, long-term studies are needed to establish that the positive effects on BMD are persistent and are associated with a reduction in fracture risk. European Journal of Endocrinology 136 282–289
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Toledano, Bryan Rene F., Maria Johanna Jaluage-Villanueva e Sharon Marisse Lacson. "Outcomes of Tricuspid Regurgitation after Percutaneous Mitral Commissurotomy". ASEAN Heart Journal 30, n. 2 (novembre 2021): 9–19. http://dx.doi.org/10.31762/ahj2130.0203.

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Abstract (sommario):
PURPOSE The gap in evidence in the management of multivalvular lesions can be addressed by providing more data on clinical and echocardiographic outcomes after Percutaneous Mitral commissurotomy (PMC). METHODS Participants were Filipinos aged >/= 19 years old, admitted due to severe mitral stenosis with moderate to severe tricuspid regurgitation (TR). The outcome of PMC was divided into 2 groups: Significant TR which included the progression of moderate to severe TR or persistence of severe TR and Insignificant TR group which included those with mild TR, regression to moderate to mild TR, severe to moderate, or persistence of moderate TR. These groups were compared from baseline, 24th hour, 1st month, and 6th month using the same echocardiographic parameters. The numerical data between significant and nonsignificant tricuspid regurgitation were compared using non-parametric Mann Whitney U test and categorical data using the Chi-Square test. RESULTS A total of 38 participants were analyzed. On the 24th-hour post- PTMC, the Significant TR group had significantly higher RAVI (42.3 vs 26.1, p=.004), RVD mid (3.81 vs 2.92, p=.001), SPAP (60.5 vs 38.5, p=.003), and RVOT (2.8 vs 2.2, p=.001) and lower MV planimetry (1.25 vs 1.58, p=.009); On the 1st-month RVD mid (3.4 vs 2.8, p=.02) and TV annulus (3.35 vs 2.76, p=0.10) were significantly higher in the Significant TR group; On the 6th month RAVI (59 vs 24.7, p=.001), RVD mid (4 vs 2.73, p=.006), and TV annulus (4.5 vs 2.67 p=.001) were significantly higher in the Significant TR group when compared to Insignificant TR group. CONCLUSION PMC improved baseline parameters of SPAP, MV planimetry, MV gradient, and functional class on short-term follow-up on both groups of TR. Majority of outcomes after the procedure had insignificant TR. However, those with significant TR had higher RVD mid and TV annulus from the 24th hour to 6 months when compared to the insignificant TR group.
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Marcucci, Guido, K. Mrózek, A. S. Ruppert, K. Maharry, J. E. Kolitz, R. J. Mayer, M. J. Pettenati et al. "t(8;21) Acute Myeloid Leukemia (AML) Differs from inv(16) AML in Pretreatment Characteristics, Outcome and Prognostic Factors Predicting Outcome: A Cancer and Leukemia Group B (CALGB) Study." Blood 104, n. 11 (16 novembre 2004): 2017. http://dx.doi.org/10.1182/blood.v104.11.2017.2017.

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Abstract (sommario):
Abstract Since t(8;21) and inv(16) disrupt core binding factor in AML and confer a favorable prognosis, these cytogenetic groups are often treated similarly, but hitherto have not been compared in a large study. We compared 144 adult AML patients (pts) with t(8;21) with 168 with inv(16) enrolled on the cytogenetic study CALGB 8461. t(8;21) pts were less frequently white (P=.01), had lower hemoglobin levels (P=.03), WBC (P<.001) and % blood (P<.001) and BM blasts (P=.005), and had more frequently secondary chromosome aberrations (P<.001) than inv(16) pts, who more often had extramedullary disease (P<.001). Pts were induced with cytarabine/daunorubicin (AD) or cytarabine/daunorubicin/etoposide ±PSC833(ADE±P). Complete remission (CR) was achieved by 89% of t(8;21) and 87% of inv(16) pts. Upon multivariable analysis (MVA), non-white race (P=.006), lower platelets (P=.01) and higher BM blasts (P=.004) predicted negatively for CR in t(8;21), and lower platelets (P=.009) and hepatomegaly (P=.04) in inv(16) pts. Non-whites with t(8;21) had 5.7 times the odds of not achieving CR as whites. For the entire group (median follow-up 6.4 yrs), the estimated 5-yr overall survival (OS) and cumulative incidence of relapse (CIR) were 51% and 53%, respectively. Pts with t(8;21) showed a trend for shorter OS (46% vs 54%; P=.17) but no difference in CIR compared with inv(16) pts. Upon MVA, t(8;21) pts had worse OS than inv(16) pts (HR 1.5; P=.04), once adjusting for age, platelets, and WBC. Following first relapse, the 5-yr survival of t(8;21) pts (n=58) was shorter than that of inv(16) pts (n=74) (14% vs 36%; P=.01); in an age-adjusted model, the risk of death was 1.8 times higher for t(8;21) pts (P=.005). In a subanalysis of pts <60 yrs, consolidation therapy with multi-course high-dose cytarabine (HDAC x3 or 4) significantly decreased CIR compared to single-course HDAC (x1) in t(8;21) (5-yr CIR, 35% vs 64%; P=.005) and inv(16) (5-yr CIR, 44% vs 70%; P =.03) pts. Upon MVA, consolidation with multi-course HDAC reduced CIR for both t(8;21) and inv(16), but other prognostic factors differed (see Table). For t(8;21), induction with ADE±P and higher platelets increased risk of relapse. However, relatively few pts received ADE±P so its prognostic impact requires confirmation. For inv(16), +22 and other secondary cytogenetic aberrations, and male sex were favorable prognostic factors. Multivariable analysis (MVA) for CIR in pts <60 yrs achieving CR on CALGB 8221, 8525, 9022, 9222, 9621 Variable t(8;21) HR (95% CI); P inv(16) HR (95% CI); P HR=Hazard Ratio, CI=confidence intervals —, not included in final model Consolidation:Single vs multi-course HDAC 4.5 (2.1-9.4); <.001 3.4 (1.7-6.6); <.001 Induction:ADE±P vs AD 2.6 (1.1-5.9); .02 1.4 (0.6-3.2); .41 log(platelets) 1.8 (1.2-2.9); .007 — Secondary cytogenetics — 0.2 (<0.1-0.5); .002 Male vs Female — 0.5 (0.3-0.9); .03 In summary, once pretreatment factors and therapy are considered, the outcome of t(8;21) AML appears inferior to that of inv(16). Although these data should be confirmed prospectively, our analysis suggests that future studies should report the outcomes of pts with t(8;21) and inv(16) separately, and seek to identify and target therapeutically leukemogenic mechanisms accountable for these clinical differences.
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Karnovsky, Sydney C., Andrew J. Rosenbaum, Bridget DeSandis, Christopher Johnson, Conor I. Murphy, Russell F. Warren, Samuel A. Taylor e Mark C. Drakos. "Radiographic Analysis of National Football League Players’ Fifth Metatarsal Morphology Relationship to Proximal Fifth Metatarsal Fracture Risk". Foot & Ankle International 40, n. 3 (7 novembre 2018): 318–22. http://dx.doi.org/10.1177/1071100718809357.

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Abstract (sommario):
Background: Fractures of the proximal fifth metatarsal are one of the most common foot injuries in athletes. Repetitive stresses endured by the fifth metatarsal can lead to stress fracture, delayed union, and refracture, making optimal treatment challenging. A radiographic analysis of fifth metatarsal morphology and foot type in National Football League (NFL) players was performed to investigate morphologic risk factors for these injuries. Methods: This was a case-control study that looked at NFL players treated between 1992 and 2012, as well as participants at the NFL Combine. Ninety-six feet (51 athletes) were included. Fractures were present in 15 feet. Two reviewers assessed fifth metatarsal morphology and foot type on anteroposterior, lateral, and oblique radiographs. Differences in foot type and metatarsal morphology between athletes with and without fractures were determined. Results: On anteroposterior radiographs, significant differences in apex medullary canal width, 4-5 intermetatarsal angle, fifth metatarsal angle, and talar head uncovering were observed between fractured and non-fractured feet ( P = .001, .003, .004, .008, respectively). On lateral radiographs, significant differences in the fifth metatarsal length, distance to apex, apex height, fifth metatarsal angle, and talocalcaneal angle were observed between fractured and nonfractured feet ( P = .04, .01, .02, .01, .01, respectively). On oblique radiographs, a significant difference was observed in apex height between fractured and nonfractured feet ( P = .002). Conclusion: Individuals with long, narrow, and straight fifth metatarsals with an adducted forefoot were most at risk for fifth metatarsal fractures. With this insight, attempts at fracture prevention can be implemented via footwear modifications, orthoses, and off-loading braces that account for those aforementioned morphologic attributes that place athletes at risk. Level of Evidence: Level III, retrospective comparative study.
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Cairo, M. S., C. Mallett, C. VandeVen, P. Kempert, G. A. Bennetts e J. Katz. "Impaired in vitro polymorphonuclear function secondary to the chemotherapeutic effects of vincristine, adriamycin, cyclophosphamide, and actinomycin D." Journal of Clinical Oncology 4, n. 5 (maggio 1986): 798–804. http://dx.doi.org/10.1200/jco.1986.4.5.798.

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Abstract (sommario):
The present study investigated the in vitro effect of four different chemotherapeutic agents, namely, cyclophosphamide (CTX), vincristine (VCR), Adriamycin (Adria Laboratories, Columbus, Ohio) (ADR), and actinomycin D (ACT-D) on human polymorphonuclear leukocyte (PMN) function. Human PMNs suspended in phosphate-buffered saline (PBS) at 1 X 10(7) cells/mL were incubated with increasing concentrations of CTX (0, 10(-5), 10(-4), 10(-3) mol/L) or VCR (0, 10(-7), 10(-6), 10(-5), 10(-4) mol/L), ADR (0, 10(-6), 10(-5), 10(-4), 10(-3) mol/L), or ACT-D (0, 5 X 10(-8), 1 X 10(-7), 5 X 10(-7), and 10(-6) mol/L). The cells were then tested for bacterial killing against Staphylococcus aureus, chemotaxis activity stimulated by Escherichia coli endotoxin, N-formyl-methionyl-leucyl-phenylalanine (FMLP)-stimulated aggregation, and cytochalasin B (Cyto B)/FMLP-stimulated superoxide production and enzyme degranulation. High concentration of CTX, an alkylating agent, showed a significant depression of PMN superoxide production, (124 +/- 13 v 161 +/- 15 nmol/10(7) cells, 5 minutes, P less than or equal to .025). ADR, an intercalating agent and membrane inhibitor, showed a significant depression of PMN degranulation and lysozyme release at 10(-4) and 10(-3) mol/L (15.3% +/- 1.7% v 24% +/- 7%, P less than .01; and 15.0% +/- 2.5% v 24% +/- 7%, P less than or equal to .025). VCR, a microtubule inhibitor, showed a significant depression of PMN aggregation at 10(-6), 10(-5), and 10(-4) mol/L (P less than .05), lysozyme release at 10(-4) mol/L (P less than .004), and beta-glucuronidase release at 10(-4) mol/L (P less than .004). In addition, chemotaxis was inhibited by VCR in a dose-dependent manner at all concentrations (10(-7) mol/L, P less than .02; 10(-6) mol/L, P less than .007; 10(-5) mol/L, P less than .006, and 10(-4) mol/L, P less than .003). ACT-D showed no significant effect on the PMN functions tested. These studies conclude that chemotherapeutic agents have modulating in vitro effects on PMN function. Further in vivo studies are therefore needed to assess PMN abnormalities in patients receiving cancer chemotherapy to determine their role in infectious complications.
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Ottinger, HD, DW Beelen, B. Scheulen, UW Schaefer e H. Grosse-Wilde. "Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow". Blood 88, n. 7 (1 ottobre 1996): 2775–79. http://dx.doi.org/10.1182/blood.v88.7.2775.bloodjournal8872775.

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Abstract (sommario):
Clinical studies are evaluating possible advantages of allogeneic peripheral blood stem cell transplantation (PBSCT) over bone marrow transplantation (BMT). We compared immune reconstitution after PBSCT (n = 20) and BMT (n = 20) in terms of lymphocyte subset counts and proliferative in vitro responses to mitogens and recall antigens (follow-up: 5 to 11 months posttransplant). Additionally, 10 PBSC harvests and 10 marrow harvests were analyzed for their composition of immunocompetent cells. Compared with BMT patients, PBSCT recipients had PB counts of naive (CD4+CD45RA+) and memory (CD4+CD45RO+) helper T cells and of B cells (CD19+) that were elevated (P &lt; .003, P &lt; .001, and P &lt; .004, respectively) and proliferative responses to phytohemagglutinin (P &lt; .0001), pokeweed mitogen (P &lt; .02), Tetanus toxoid (P &lt; .0005), and Candida (P &lt; .004) that were increased. PBSCT recipients received a mean of 188 (range, 44 to 280) x 10(6) naive helper T cells and 169 (range, 18 to 296) x 10(5) memory helper T cells per kilogram; the corresponding numbers for BMT recipients were 11 (range, 4 to 24) and 10 (range, 1 to 22) x 10(5) cells per kilogram, respectively. The question of whether the documented improved in vitro immune competence after PBSCT is associated with a lower incidence of infectious complications in vivo still needs further study.
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Ortiz, Johana, John Van Camp, Sylviana Wijaya, Silvana Donoso e Lieven Huybregts. "Determinants of child malnutrition in rural and urban Ecuadorian highlands". Public Health Nutrition 17, n. 9 (30 settembre 2013): 2122–30. http://dx.doi.org/10.1017/s1368980013002528.

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Abstract (sommario):
AbstractObjectiveTo identify and compare the sociodemographic determinants of stunting, wasting and overweight among infants of urban and rural areas in the Ecuadorian highlands.DesignCross-sectional study.SettingNabon (rural) and Cuenca (urban) cantons, Azuay Province, Ecuador.SubjectsA total of 703 children aged 0–24 months and their caregivers (227 rural and 476 urban) recruited during the period from June to September 2008.ResultsStunting prevalence was significantly higher in the rural area (37·4 %v. 17·7 %;P< 0·001) while wasting (7·1 %) and overweight (17·1 %) prevalence were more similar between areas. Determinants of stunting for the pooled sample were male gender (OR = 1·43; 95 % CI 1·06, 1·92;P= 0·02), preterm delivery (OR = 1·65; 95 % CI 1·14, 2·38;P= 0·008), child's age (OR = 1·04; 95 % CI 1·01, 1·07;P= 0·011), maternal education (OR = 0·95; 95 % CI 0·92, 0·99;P= 0·025) and facility-based delivery (OR = 0·57; 95 % CI 0·45, 0·74;P< 0·001). The latter was also a determinant of overweight (OR = 0·39; 95 % CI 0·25, 0·62;P< 0·001). Rural determinants of stunting were maternal height (OR = 0·004; 95 % CI 0·00004, 0·39;P= 0·018), diarrhoea prevalence (OR = 2·18; 95 % CI 1·13, 4·21;P= 0·02), socio-economic status (OR = 0·79; 95 % CI 0·64, 0·98;P= 0·030) and child's age (OR = 1·07; 95 % CI 1·02, 1·11;P= 0·005). Urban determinants were: maternal BMI for stunting (OR = 0·91; 95 % CI 0·84, 0·99;P= 0·027), cough prevalence (OR = 0·57; 95 % CI 0·34, 0·96;P= 0·036) and facility-based delivery (OR = 0·25; 95 % CI 0·09, 0·73;P= 0·011) for overweight, and hygiene for wasting (OR = 0·57; 95 % CI 0·36, 0·89;P= 0·013).ConclusionsInfant malnutrition was associated with different sociodemographic determinants between urban and rural areas in the Ecuadorian highlands, a finding which contributes to prioritize the determinants to be assessed in nutritional interventions.
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Hinneburg, Alexander [Verfasser], Stefan Akademischer Betreuer] Brass, Thomas [Akademischer Betreuer] Seidl e Myra [Akademischer Betreuer] [Spiliopoulou. "Text mining and applications in life sciences / Alexander Hinneburg. Betreuer: Stefan Brass ; Thomas Seidl ; Myra Spiliopoulou". Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://nbn-resolving.de/urn:nbn:de:gbv:3:4-7603.

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Clauss, Huebner, Kempe, Richter e Riedel. "Mitteilungen des URZ 4/1991". Universitätsbibliothek Chemnitz, 1995. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199500247.

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Huebner, Mueller, Riedel e Ziegler. "Mitteilungen des URZ 4/1992". Universitätsbibliothek Chemnitz, 1995. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199500213.

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Fischer, Günther, Ludwig Wolf, Jens Wagner, Wolfgang Riedel, Steffen Brose, Ursula Riedel, Rolf Köbe e Frank Richter. "Mitteilungen des URZ 4/1995". Universitätsbibliothek Chemnitz, 1995. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199500125.

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Müller, Thomas, Frank Richter, Wolfgang Riedel, Christoph Ziegler e Jan Martin. "Mitteilungen des URZ 4/2009". Universitätsbibliothek Chemnitz, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200901946.

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Leuthäuser, Max [Verfasser], Uwe [Akademischer Betreuer] Aßman, Christel [Akademischer Betreuer] Baier, Uwe [Gutachter] Aßmann e Anthony [Gutachter] Sloane. "A Pure Embedding of Roles : Exploring 4-dimensional Dispatch for Roles in Structured Contexts / Max Leuthäuser ; Gutachter: Uwe Aßmann, Anthony Sloane ; Uwe Aßman, Christel Baier". Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://d-nb.info/1139977555/34.

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Berges, Marc-Pascal Verfasser], Peter [Akademischer Betreuer] Hubwieser e Torsten [Akademischer Betreuer] [Brinda. "Object-Oriented Programming through the Lens of Computer Science Education / Marc-Pascal Berges. Gutachter: Peter Hubwieser ; Torsten Brinda. Betreuer: Peter Hubwieser". München : Universitätsbibliothek der TU München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20150723-1245597-1-4.

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Mühe, Henrik Verfasser], Alfons [Akademischer Betreuer] [Kemper, Thomas [Akademischer Betreuer] Neumann e Gerhard [Akademischer Betreuer] Weikum. "Concurrency in Main-Memory Database Systems / Henrik Mühe. Gutachter: Thomas Neumann ; Alfons Kemper ; Gerhard Weikum. Betreuer: Alfons Kemper". München : Universitätsbibliothek der TU München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20141001-1209942-0-4.

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Schütte, Julian Hendrik Verfasser], Claudia [Akademischer Betreuer] [Eckert e Stefan [Akademischer Betreuer] Katzenbeisser. "Security Policies in Pervasive Systems : Design of a Modular Security Policy Framework for Semantic, Multi-Domain, Service-Oriented Pervasive Systems / Julian Hendrik Schütte. Gutachter: Claudia Eckert ; Stefan Katzenbeisser. Betreuer: Claudia Eckert". München : Universitätsbibliothek der TU München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20130813-1128393-0-4.

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Butnaru, Daniel Verfasser], Hans-Joachim [Akademischer Betreuer] [Bungartz e Ernst [Akademischer Betreuer] Rank. "Computational Steering with Reduced Complexity / Daniel Butnaru. Gutachter: Hans-Joachim Bungartz ; Ernst Rank. Betreuer: Hans-Joachim Bungartz". München : Universitätsbibliothek der TU München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20130711-1140571-0-4.

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Libri sul tema "004.02 : 004.4"

1

Library, Community Services Victoria. Equal employment opportunity: Resource list no. 4, October 1991 LIBRM 004. [Fitzroy, Vic.]: Staff Development Branch, 1991.

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Kadlec, Jaroslav. Prehled ceskych cirkevnich dejin. Vol. 1. Praha: ZVON, Ceske katolicke nakladatelstvi, 1991.

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Аммерал, Л. Программирование графики на Турбо Си. Москва: Сол Систем, 1992.

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Чернадчук, В. Д. Правовая статистика. Київ: МАУП, 1999.

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Dessì, Giuseppe. Diari 1952-1962. A cura di Francesca Nencioni e Franca Linari. Florence: Firenze University Press, 2011. http://dx.doi.org/10.36253/978-88-6655-004-4.

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Abstract (sommario):
In these private notes, the quest for the self appears like a journey of dual metaphorical significance through the intricate weft of the pages and the labyrinth of life. The Diari 1952-1962 of Giuseppe Dessí are presented here in Franca Linari's meticulous transcription accompanied by an introduction and an attentive commentary by Francesca Nencioni. Following the previous volumes, which made it possible to reconstruct the history of his youthful education and the productions of his early maturity, this one now reveals significant changes in the writer's life. A new female figure (Luisa) accompanies a period in which the narrative production that has become the dominant passion becomes decidedly more intensive and continuative, hand-in-hand with an increase in the collaborations with journals and the desire to experiment new forms of expression ushered in by the theatre.
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Овсійчук, В. А. Класицизм і романтизм в українському мистецтві. Київ: Дніпро, 2001.

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Лорендзатос, Зисимос. [Дослідження. Vol. 2. Афіни: Домос, 1994.

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Agung, Indonesia Mahkamah. Keputusan bersama Ketua Mahkamah Agung RI dan Menteri Agama RI nomor KMA/001/SK/I/1983 dan nomor 1 tahun 1983, nomor KMA/002/SK/I/1983 dan nomor 2 tahun 1983, nomor KMA/003/SK/I/1983 dan nomor 3 tahun 1983, nomor KMA/004/SK/I/1983 dan nomor 4 tahun 1983, dan Peraturan Menteri Agama RI nomor 1 tahun 1983 Tentang Pemberi Bantuan Hukum pada Peradilan Agama. [Jakarta]: Departemen Agama RI, Ditjen Binbaga Islam, Ditbinbapera Islam, 1989.

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General Livestock (048-004-02428-4). US Government Printing Office, 2000.

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Huguenin, Timothy G., C. P. Dunphey, Peter Rawlik, Drew Nicks, Joshua Chaplinsky, G. D. Watry, Seras Nikita et al. Hinnom Magazine Issue 004 (Volume 4). Gehenna & Hinnom Books, 2017.

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Capitoli di libri sul tema "004.02 : 004.4"

1

Goldschmidt, David. "Group characters". In Group Characters, Symmetric Functions, and the Hecke Algebra, 5–9. Providence, Rhode Island: American Mathematical Society, 2002. http://dx.doi.org/10.1090/ulect/004/02.

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Kaczor, W., e M. Nowak. "Sequence of real numbers". In The Student Mathematical Library, 19–61. Providence, Rhode Island: American Mathematical Society, 2000. http://dx.doi.org/10.1090/stml/004/02.

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Rubin, Karl. "More “Main conjectures” for imaginary quadratic fields". In CRM Proceedings and Lecture Notes, 23–28. Providence, Rhode Island: American Mathematical Society, 1994. http://dx.doi.org/10.1090/crmp/004/02.

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Lohkamp, Joachim. "Global and local curvatures". In Fields Institute Monographs, 23–51. Providence, Rhode Island: American Mathematical Society, 1996. http://dx.doi.org/10.1090/fim/004/02.

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Gordon, Russell. "Measurable functions". In Graduate Studies in Mathematics, 17–27. Providence, Rhode Island: American Mathematical Society, 1994. http://dx.doi.org/10.1090/gsm/004/02.

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Gieseker, David. "Geometric invariant theory and the moduli of bundles". In IAS/Park City Mathematics Series, 5–21. Providence, Rhode Island: American Mathematical Society, 1997. http://dx.doi.org/10.1090/pcms/004/02.

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Ashley, J., B. Grünbaum, G. Shephard e W. Stromquist. "Self-duality groups and ranks of self-dualities". In DIMACS Series in Discrete Mathematics and Theoretical Computer Science, 11–50. Providence, Rhode Island: American Mathematical Society, 1991. http://dx.doi.org/10.1090/dimacs/004/02.

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Keenan, Edward. "4. Quantifiers". In Semantics - Noun Phrases and Verb Phrases, a cura di Paul Portner, Klaus Heusinger e Claudia Maienborn, 112–48. Berlin, Boston: De Gruyter, 2019. http://dx.doi.org/10.1515/9783110589443-004.

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Zamparelli, Roberto. "4. Coordination". In Semantics - Sentence and Information Structure, a cura di Paul Portner, Claudia Maienborn e Klaus von Heusinger, 135–70. Berlin, Boston: De Gruyter, 2019. http://dx.doi.org/10.1515/9783110589863-004.

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Spange, Stefan, Mandy Göring, Lysann Kaßner, Kevin Nagel, Andreas Seifert, Thomas Ebert, Philipp Kitschke, Michael Mehring e Heinrich Lang. "4. Materials". In Twin Polymerization, a cura di Stefan Spange e Michael Mehring, 167–272. Berlin, Boston: De Gruyter, 2018. http://dx.doi.org/10.1515/9783110499360-004.

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Atti di convegni sul tema "004.02 : 004.4"

1

"1ISG-004 Abstract withdrawn". In 24th EAHP Congress, 27th–29th March 2019, Barcelona, Spain. British Medical Journal Publishing Group, 2019. http://dx.doi.org/10.1136/ejhpharm-2019-eahpconf.4.

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Wilmshurst, S., e K. Railton. "004 A smart (phone) solution for journal club". In Great Ormond Street Hospital Conference 2018: Continuous Care. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2018. http://dx.doi.org/10.1136/goshabs.4.

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Becker, Philip, Robert Hofmann e Benny Chemnitz-Nielsen. "PWE-004 Tapering with budesonide – label recommendation versus clinical reality". In British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.136.

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Zhou*, Xiyan, Xu Chang, Yibo Wang e Zhenxing Yao. "P- and S-wave separation of microseismic data by wavefield extrapolation method". In 2017 Workshop: Microseismic Technologies and Applications, Hefei, China, 4-6 June 2017. Society of Exploration Geophysicists, 2017. http://dx.doi.org/10.1190/microseismic2017-004.

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Ahmad, Omer F., Imanol Luengo, Luis Garcia Peraza Herrera, Patrick Brandao, Wenqi Li, Martin Everson, Rehan Haidry et al. "PTH-004 Deep learning for real-time automated polyp localisation in colonoscopy videos". In British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.26.

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Gil-Sierra, MD, S. Fenix-Caballero, MDP Briceño-Casado, M. Dominguez-Cantero e EJ Alegre-Del Rey. "1ISG-004 Economic comparison of therapeutic alternatives for firstline treatment of multiple myeloma". In 25th EAHP Congress, 25th–27th March 2020, Gothenburg, Sweden. British Medical Journal Publishing Group, 2020. http://dx.doi.org/10.1136/ejhpharm-2020-eahpconf.4.

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Supan, Maureen Khimmery Betito, Bianca Marie Miranda Severino e Neil Castañeda Tanquilut. "004: ANTI-FATIGUE EFFECT OF KAWAYANG TINIK (BAMBUSA BLUMEANA) SHOOT EXTRACTS IN MICE". In Global Forum on Research and Innovation for Health 2015. British Medical Journal Publishing Group, 2015. http://dx.doi.org/10.1136/bmjopen-2015-forum2015abstracts.4.

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Carrez, L., V. Martin, M. Jermini, V. Malet, L. Bouchoud, L. Falaschi e P. Bonnabry. "1ISG-004 Impact of a lean approach on the organisation of a chemotherapy production unit". In Abstract Book, 23rd EAHP Congress, 21st–23rd March 2018, Gothenburg, Sweden. British Medical Journal Publishing Group, 2018. http://dx.doi.org/10.1136/ejhpharm-2018-eahpconf.4.

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Delgado Almandoz, J., Y. Kayan, A. Copelan e J. Scholz. "O-004 Aneurysm occlusion rate decreases with increasing WEB width despite adequate WEB lateral compression". In SNIS 18TH ANNUAL MEETING. BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd., 2021. http://dx.doi.org/10.1136/neurintsurg-2021-snis.4.

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Yeh, Wei Z., Putu A. Widyastuti, Anneke Van der Walt, Jim Stankovich, Eva K. Havrdova, Dana Horakova, Karolina Vodehnalova et al. "004 Pregnancy-related relapse in natalizumab, fingolimod and dimethyl fumarate-treated women with multiple sclerosis". In ANZAN Annual Scientific Meeting 2021 Abstracts. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/bmjno-2021-anzan.4.

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Rapporti di organizzazioni sul tema "004.02 : 004.4"

1

Erika Bailey. Revised FINAL?REPORT NO. 2: INDEPENDENT CONFIRMATORY SURVEY SUMMARY AND RESULTS FOR THE ENRICO FERMI ATOMIC POWER PLANT, UNIT 1, NEWPORT, MICHIGAN (DOCKET NO. 50 16; RFTA 10-004) 2018-SR-02-1. Office of Scientific and Technical Information (OSTI), ottobre 2011. http://dx.doi.org/10.2172/1034266.

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