Littérature scientifique sur le sujet « XIAP inhibitors »
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Articles de revues sur le sujet "XIAP inhibitors"
Löder, Sandra, Melanie Fakler, Irmela Jeremias, Klaus-Michael Debatin et Simone Fulda. « XIAP Inhibitors Present a Promising New Strategy to Sensitize Childhood Acute Leukemia Cells for Chemotherapy-Induced Apoptosis. » Blood 114, no 22 (20 novembre 2009) : 3791. http://dx.doi.org/10.1182/blood.v114.22.3791.3791.
Texte intégralLoeder, Sandra, Thorsten Zenz, Andrea Schnaiter, Daniel Mertens, Dirk Winkler, Hartmut Döhner, Klaus-Michael Debatin, Stephan Stilgenbauer et Simone Fulda. « A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia. » Blood 114, no 22 (20 novembre 2009) : 731. http://dx.doi.org/10.1182/blood.v114.22.731.731.
Texte intégralFakler, Melanie, Sandra Löder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin et Simone Fulda. « Small Molecule XIAP Inhibitors Cooperate with TRAIL to Trigger Apoptosis in Childhood Acute Leukemia Cells and Overcome Bcl-2-Mediated Resistance ». Blood 112, no 11 (16 novembre 2008) : 857. http://dx.doi.org/10.1182/blood.v112.11.857.857.
Texte intégralSchimmer, Aaron D., Marcela Gronda, Zhiliang Wang, Kate Welsh, Clemencia Pinilla, Michael Andreeff, Wendy D. Schober et al. « Small-Molecule XIAP Inhibitors Derepress Downstream Effector Caspases and Induce Apoptosis of Leukemia Cell Lines and Patient Samples. » Blood 104, no 11 (16 novembre 2004) : 759. http://dx.doi.org/10.1182/blood.v104.11.759.759.
Texte intégralSchimmer, Aaron D., et Shadi Dalili. « Targeting the IAP Family of Caspase Inhibitors as an Emerging Therapeutic Strategy ». Hematology 2005, no 1 (1 janvier 2005) : 215–19. http://dx.doi.org/10.1182/asheducation-2005.1.215.
Texte intégralSchimmer, Aaron D., et Shadi Dalili. « Targeting the IAP Family of Caspase Inhibitors as an Emerging Therapeutic Strategy ». Hematology 2005, no 1 (1 janvier 2005) : 215–19. http://dx.doi.org/10.1182/asheducation.v2005.1.215.215.
Texte intégralFakler, Melanie, Sandra Loeder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin et Simone Fulda. « Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2–mediated resistance ». Blood 113, no 8 (19 février 2009) : 1710–22. http://dx.doi.org/10.1182/blood-2007-09-114314.
Texte intégralSeno, Saki, Minori Kimura, Yuki Yashiro, Ryutaro Kimura, Kanae Adachi, Aoi Terabayashi, Mio Takahashi et al. « β-Thujaplicin Enhances TRAIL-Induced Apoptosis via the Dual Effects of XIAP Inhibition and Degradation in NCI-H460 Human Lung Cancer Cells ». Medicines 8, no 6 (2 juin 2021) : 26. http://dx.doi.org/10.3390/medicines8060026.
Texte intégralCillessen, Saskia A. G. M., John C. Reed, Kate Welsh, Clemencia Pinilla, Richard Houghten, Erik Hooijberg, José Deurhof et al. « Small-molecule XIAP antagonist restores caspase-9–mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells ». Blood 111, no 1 (1 janvier 2008) : 369–75. http://dx.doi.org/10.1182/blood-2007-04-085480.
Texte intégralGaponova, Tatyana, Andrey Misurin, Larisa Mendeleeva, Elena Varlamova, Elena Parovichnikova et Valeryi Savchenko. « Expression of XIAP in Multiple Myeloma Patients ». Blood 112, no 11 (16 novembre 2008) : 5118. http://dx.doi.org/10.1182/blood.v112.11.5118.5118.
Texte intégralThèses sur le sujet "XIAP inhibitors"
Allwood, Daniel Martin. « Discovery and development of novel non-peptidomimetic inhibitors of XIAP ». Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607657.
Texte intégralFarag, Marc. « Conception assistée par ordinateur d'inhibiteurs de XIAP ». Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC264.
Texte intégralSince their discovery, protein-protein interactions (PPIs) have been at the heart of many biological processes. These PPIs can be drug targets, either by mimicking a defective interaction or by inhibiting an inadequate interaction. Among the most implicated PPIs in pathologies, we found the Inhibitor Apoptosis Proteins (AAPs). These members are considered as key regulators of programmed cell death and, within the cell signalling pathways, XIAP, a member of the IAP family, is one of the most targeted proteins actually. Its involvement in cancers and rare inflammatory diseases makes it a therapeutic target of choice. Recent data in the literature have highlighted the importance of designing selective disruptors for this protein in order to avoid serious adverse effects. For this reason, it is essential to know the essential structural elements associated with the different domains of this protein, which distinguish it from other similar members of the IAP family. It is also essential to know the interaction mechanisms in which XIAP is involved with its partners. CADD tools, in particular the Structure-based drug design approach, as well as experimental evaluation techniques using fluorescence anisotropy (FPA) or AlphaScreen® technology were used as part of this thesis work. The results of in silico and in vitro work led to rational design proposals of selective small molecules that could potentially disrupt XIAP-mediated PPIs
Reiser, Marc [Verfasser]. « Sensitization of pancreatic carcinoma cells for chemotherapy-induced apoptosis using small-molecule inhibitors of X-linked inhibitor of apoptosis protein (XIAP) / Marc Reiser ». Ulm : Universität Ulm, 2020. http://d-nb.info/1205001867/34.
Texte intégralConnolly, Kathryn C. « X-linked inhibitor of Apoptosis (XIAP) in colorectal cancer models ». Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/24478.
Texte intégralLiwak-Muir, Urszula. « The Function and Regulation of PDCD4 - A Novel Inhibitor of Selective Translation Initiation ». Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31375.
Texte intégralAguilar, Claire. « Caractérisation de la pathologie intestinale associée au déficit en XIAP (X-linked inhibitor of apoptosis protein) ». Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T072.
Texte intégralMutations in the gene encoding for XIAP (X-Linked Inhibitor of Apoptosis Protein) are causing the X-linked lymphoproliferative syndrome type 2 (XLP-2). It is a rare immunodeficiency characterized by an abnormal susceptibility to infection with Epstein Barr virus (EBV). In addition, some XIAP-deficient patients may suffer from an intestinal disease that can be severe. XIAP is an anti-apoptotic molecule which has also been involved in the signaling and the functions of receptors of the innate immunity, NOD1 and NOD2. My thesis work aimed to characterize this intestinal pathology and its pathophysiology. For this, we studied a cohort of known XIAP-deficient patients with inflammatory bowel disease. We also looked for mutations of XIAP in a cohort of children who presented as the only clinical sign an early intestinal pathology. In 83 patients tested, three were identified as carrier of a XIAP mutation. We then showed that this intestinal pathology is clinically and histologically very close to Crohn’s disease, which is a major inflammatory bowel disease in adults. Crohn's disease is associated with environmental factors and genetic susceptibility, including polymorphisms in the NOD2 gene that represent the most important factor identified to date. We then showed that the monocytes from XIAP-deficient patients have a defect in production of IL-8, MCP-1 and IL-10 in response to stimulation of the NOD2 pathway. However, we did not reveal any excess of apoptosis in intestinal epithelial cells from XIAP-deficient patients. On the other hand, they showed a decreased number of their circulating innate T cells. Finally, during this study, we identified for the first time, female carriers of a mutation of XIAP in the heterozygous state, who developed intestinal inflammatory manifestations. In these patients, the inactivation of the X chromosome, which is normally biased toward the healthy allele in asymptomatic vectors, is biased to the unusually mutated allele contributing to a decrease of the expression of XIAP in monocytes and an alteration of the NOD2 pathway. This work showed that XIAP deficiency is responsible for a monogenic form of Crohn's disease. Our results suggest that the lack of monocyte activation by NOD2 is an important mechanism in the pathogenesis of the disease. Therapeutically, the bone marrow transplant seems indicated in severe cases, since the main identified defect is an abnormality of the hematopoietic compartment and in two of our patients, it allowed a clear improvement of the digestive pathology that was very severe
Fong, Wai Gin. « The candidate tumour suppressor, XIAP associated factor 1 (XAF1), directly inhibits XIAP activity and induces G1 phase cell cycle arrest ». Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/28983.
Texte intégralMori, Tomohiko. « Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells ». Kyoto University, 2009. http://hdl.handle.net/2433/124345.
Texte intégralCheema, Tasbir. « Rational Design, Synthesis and Evaluation of Novel Second Mitochondrial-Derived Activators of Caspase (Smac) Mimetics That Induce Apoptosis in Human MDA-MB-231 Breast Cancer Cell Line ». Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20737.
Texte intégralSteen, Håkan. « Novel Interactors of X-linked Inhibitor of Apoptosis Protein : Expression and Effects on Tumor Cell Death ». Doctoral thesis, Uppsala University, Neurobiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8742.
Texte intégralProgrammed cell death, or apoptosis, has during the last decade received a lot of attention due to its involvement in a large number of pathological conditions. Since death is always irreversible, it is important for cells to fully control the initiation and execution of this process. One of many apoptosis-regulatory proteins is XIAP, which blocks the action of caspases, a family of proteases that are important during apoptosis. However, apoptosis inhibitors have to be tightly controlled since too little cell death can lead to the development of tumors and other diseases. This thesis is the result of an aspiration to fully understand the function and regulation of XIAP.
By using the yeast-2-hybrid system, we identified two novel binding partners of XIAP. The first, GPS2, was found to bind XIAP and inhibit its ability to block caspase-activity. In addition, GPS2 induced caspase-mediated cell death in two different tumour cell lines and XIAP inhibited this effect.
The second binding partner, Nulp1, preferentially bound XIAP in the presence of the apoptosis-inducer staurosporine. Nulp1 induced or sensitized cell lines to cell death when overexpressed, but this was not blocked by caspase-inhibitors or XIAP, suggesting a different reason for binding than apoptosis regulation. With the aim to understand the Nulp1-XIAP interaction, we continued to study Nulp1 in vivo and in vitro. We studied three different splice variants of Nulp1 and found that they were regulated by poly-ubiquitination and nuclear shuttling. Also, Nulp1 was expressed in embryonic mice, especially in the cortical plate, hippocampal neurons and cerebellar granular neurons. Expression of Nulp1 decreased with age but was still present in cerebellar deep nuclei and Purkinje cells of adult mice.
To summarize, we have identified GPS2 as an apoptosis-inducing factor and an inhibitor of XIAP in vitro, and Nulp1 as a XIAP-interacting protein during staurosporine-induced apoptosis.
Chapitres de livres sur le sujet "XIAP inhibitors"
Idnani, Tasha Annakin S., et Yong Hsuen Wei Melissa. « Engineering of a Novel Inhibitor of Factor XIa with Better Stability and Inhibitory Efficiency ». Dans IRC-SET 2020, 151–61. Singapore : Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-9472-4_13.
Texte intégralYang, Wu, James R. Corte et Joseph M. Luettgen. « RECENT PROGRESS IN FACTOR XI/XIA INHIBITOR DISCOVERY ». Dans 2022 Medicinal Chemistry Reviews, 117–41. Washington, DC : MEDI, Inc. Published by American Chemical Society., 2022. http://dx.doi.org/10.1021/mc-2022-vol57.ch05.
Texte intégralTey, B. T., K. C. Yap, A. M. Ali et W. S. Tan. « The X-link inhibitor of apoptosis protein (XIAP) enhances the survivability of C2E7 hybridoma cells under a serum deprived condition ». Dans Animal Cell Technology : Basic & ; Applied Aspects, 67–72. Dordrecht : Springer Netherlands, 2006. http://dx.doi.org/10.1007/1-4020-4457-7_9.
Texte intégralFredenburgh, James C., et Jeffrey I. Weitz. « Forthcoming oral factor XIa and factor XIIa inhibitors ». Dans The ESC Textbook of Thrombosis, sous la direction de Raffaele De Caterina, David J. Moliterno et Steen Dalby Kristensen, 133–40. Oxford University PressOxford, 2023. http://dx.doi.org/10.1093/med/9780192869227.003.0012.
Texte intégralYim, JH, WG Kim, G. Gong, EY Kim, TY Kim, JH Joon, SJ Hong, WB Kim et YK Shong. « X-Linked Inhibitor of Apoptosis (XIAP) in Papillary Thyroid Carcinoma. » Dans The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego, P1–534—P1–534. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part1.p11.p1-534.
Texte intégralActes de conférences sur le sujet "XIAP inhibitors"
Kawamura, Tatsuro, Hitomi Otaka, Etsu Tashiro et Masaya Imoto. « Abstract B157 : Generation of “Natural Unnatural Product Library” and identification of small molecule XIAP inhibitors ». Dans Abstracts : AACR-NCI-EORTC International Conference : Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009 ; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-b157.
Texte intégralChessari, Gianni, Ildiko Buck, Elisabetta Chiarparin, James Day, Martyn Frederickson, Keisha Hearn, Tom Heightman et al. « Abstract 2018 : Discovery of potent dual inhibitors of both XIAP and cIAP1 using fragment based drug discovery ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2018.
Texte intégralVellanki, Sri Harikrishna, Andreas Grabrucker, Stefan Liebau, Adriana Eramo, Veit Braun, Tobias Böckers, Klaus-Michael Debatin et Simone Fulda. « Abstract 3480 : XIAP inhibitors prime glioblastoma cells for γ-irradiation-induced apoptosis and circumvent radioresistance of glioblastoma stem cells ». Dans Proceedings : AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010 ; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3480.
Texte intégralTans, G., T. Janssen-Claessen, J. Rosing et J. H. Griffin. « APPLICATION OF SPECIFIC SERINE PROTEASE INHIBITORS IN ASSAYS FOR ACTIVATED CONTACT FACTORS. » Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643301.
Texte intégralAhmed, Maqbool, Azhar R. Hussain, Shaham Beg, Saravanan Thangavel, Rafia Begum, Dahish Ajarim, Fouad Al-Dayel, Abdul Khalid Siraj K. Siraj et Khawla S. Al-kuraya. « Abstract 4405 : Over-expression of PARP is associated with an aggressive phenotype and can be synergistically targeted using combination of PARP and XIAP inhibitors in breast cancer ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4405.
Texte intégralFakler, Melanie, Sandra Löder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin et Simone Fulda. « Abstract 2911 : Small molecule XIAP inhibitors sensitize acute leukemia cells for TRAIL- or chemotherapy-induced apoptosis, overcome Bcl-2-mediated resistance and reduce leukemic burden in vivo in NOD/SCID mice ». Dans Proceedings : AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010 ; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2911.
Texte intégralFakler, Melanie, Sandra Loeder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus‐Michael Debatin et Simone Fulda. « Abstract PR-8 : XIAP inhibitors prime acute leukemia cells for TRAIL‐ or chemotherapy‐induced apoptosis, bypass Bcl‐2‐imposed resistance and exert antileukemic activity in a NOD/SCID mouse model of pediatric acute leukemia ». Dans Abstracts : AACR-NCI-EORTC International Conference : Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009 ; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-pr-8.
Texte intégralWalsh, P. N., D. Sinha, F. Kueppers, F. S. Seaman et K. B. Blanketein. « THE REGULATION OF FACTOR XIa ACTIVITY BY PLATELETS AND ALPHA-1-PROTEASE INHIBITOR ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642805.
Texte intégralLi, Fengzhi, Shousong Cao et Xiang Ling. « Abstract 3446 : FL118, a survivin/Mcl-1/XIAP/cIAP2-selective inhibitor, effectively inhibits human mesothelioma xenograft growth in animal models. » Dans Proceedings : AACR 104th Annual Meeting 2013 ; Apr 6-10, 2013 ; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-3446.
Texte intégralHongo, Fumiya, Natsuki Takaha, Yasunori Kimura, Terukazu Nakamura, kazuya Mikami et Tsuneharu Miki. « Abstract 4493 : Serum X-linked inhibitor of apoptosis protein (XIAP) predictive recurrence of renal cell carcinoma ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4493.
Texte intégralRapports d'organisations sur le sujet "XIAP inhibitors"
Lu, Yipin. Discovery and Test of Small Molecule Inhibitions of XIAP as Potential Novel Therapy for the Treatment of Breast Cancer. Fort Belvoir, VA : Defense Technical Information Center, avril 2005. http://dx.doi.org/10.21236/ada435631.
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