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Littérature scientifique sur le sujet « Xenomatrix »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "Xenomatrix"

Diuriagina, O. V., M. V. Chepeleva, E. I. Kuznetsova, M. A. Kovinka et A. N. Nakoskin. « The effect of implantation materials based on equine and bovine xenogenic bone extracellular matrix on the formation of extracellular neutrophilic traps (experimental study) ». Genij Ortopedii 26, n^o 4 (décembre 2020) : 571–75. http://dx.doi.org/10.18019/1028-4427-2020-26-4-571-575.

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Purpose To study the effect of osteoplastic materials based on the extracellular xenomatrix of bovine and equine bone tissue on the formation of neutrophil extracellular traps (NETs) in the peripheral blood of rabbits in the early post-operative period after implantation. Materials and methods The study was carried out on 18 male rabbits of the Soviet Chinchilla breed, aged from 8 months to 1.2 years, weighing from 3.0 to 4.5 kg. A perforated bone defect of a cylindrical shape measuring 2 x 6 mm in the distal metaphysis of the right and left femurs was modeled in the animals. The rabbits were divided into three groups, six animals each. In group I, the bone defect was left unfilled; in group II, the defect was filled with a bovine bone tissue xenomatrix, and an equine bone tissue xenomatrix was implanted in group III animals. The implantation material had the appearance of a yellowish crumb with a particle size of 0.5– 1 mm. Blood smears stained according to Romanovsky-Giemsa were used for counting extracellular neutrophil traps (NETs). The percentage of neutrophils that passed the stages of nuclear transformation and emitted free chromatin into the extracellular space in the form of network-like structures was calculated. Results On days 3–7 of the experiment, the number of NETs increased in the early stages of NETosis in all groups. There were no significant differences between the groups. In group I, on days 7 and 14, the number of early forms of NETs (stages 1a and 1b) returned to the values of the preoperative period. In groups II and III, normalization of NETs (stage 1a) did not occur, and the content of NETs (stage 1b) returned to the initial level only by day 30 of the experiment. On days 3, 7, 14, the number of mature NETs increased in all groups. The highest values were noted in group II, where the bovine xenogeneic matrix was implanted. Conclusion Implantation materials based on the extracellular matrix of equine and bovine xenogeneic bone stimulate excessive formation of early NETs on days 14–30 of the experimental period in response to xenotransplantation. Xenomaterials of bovine bone tissue, in comparison with xenomaterials of equine bone tissue, induce a more pronounced inflammatory reaction in the nearest time after defect filling, which is manifested by higher production of mature NETs on days 3–14 of the experiment.

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Stogov, M. V., O. V. Dyuryagina, T. A. Silant'eva, E. A. Kireeva, I. V. Shipitsyna et M. A. Stepanov. « Preclinical evaluation of the efficacy and safety of a new osteoplastic material of xenogenic origin containing vancomycin or meropenem ». Genij Ortopedii 28, n^o 4 (août 2022) : 565–73. http://dx.doi.org/10.18019/1028-4427-2022-28-4-565-573.

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Bone xenomatrix is an available material for plasty due to its availability and possible significant modification. The purpose was comparative evaluation of the efficacy and safety of xenogenic bone graft material impregnated with antibiotics, vancomycin or meropenem, in an experiment on a model of long bone defect healing in rabbits. Methods The study was performed on 28 male rabbits aged from 8 months to 1.2 years. All animals were modeled with a cavity defect of the right and left distal femoral metaphysis measuring 4 × 4 × 6 mm. Bone matrix blocks of the same size were implanted into the defect cavity. Animals of group 1 (n = 8, control) were implanted with a free “clean” bone block. Animals of group 2 (n = 10) with a bone block saturated with vancomycin. Animals of group 3 (n = 10) with a bone block impregnated with meropenem. To assess the effectiveness and safety of the material, clinical, radiological, pathomorphological, histological, and laboratory methods were used. Results X-ray signs of substitution of the studied materials in the defect in animals of group 1 were noted by 182 days, in group 2 – by 84 days, in group 3 – about 182 days. In each group, there was a complication, arthrosis of the knee joint (one animal in each group). According to the histological study, it was found that in groups 2 and 3, a complete elimination of xenomaterial in the middle part of the defect and its replacement with trabecular bone was noted by 182 days after implantation. The severity of irritating action of the materials in the animals of groups 2 and 3 did not exceed the control value. The laboratory blood tests in the animals of groups 2 and 3 also did not reveal significant differences with group 1. Conclusion The developed osteoplastic materials based on bovine bone xenomatrix, impregnated with vancomycin or meropenem, have acceptable safety and efficacy characteristics.

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Luneva, S. N., I. V. Shipitsyna, M. V. Chepeleva, O. V. Dyuryagina et M. A. Kovinka. « CHANGING THE RABBITS’ HEMATOLOGICAL VALUES AFTER INTRODUCING IMPLANTATION MATERIAS BASED ON THE HORSE BONE TISSUE XENOMATRIX INTO THE ARTIFICIALLY PRODUCED BONE DEFECT ». Современные проблемы науки и образования (Modern Problems of Science and Education), n^o 6 2018 (2018). http://dx.doi.org/10.17513/spno.28322.

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« {BLR 2728} Abgenix - Agrichemicals - AIDS - Allergene - American Biogenetic Sciences - Antimicrobials - ArQule - Asahi Chemical - Aurora Biosciences - Aviron - Beckman Coulter - Biosearch Italia - Biovector Therapeutics - Bladder Cancer - Cell Genesys - Cerep - CombiChem - CompuCyte - Connetics - CSL Limited - CTLA-4 - Dendritic Cells - DNA Microarrays - DNA Vaccines - Elan Corp. - ErythroMed - Galileo Laboratories - Gene Expression Profiling - Gene Therapy - GeneMedicine - Genentech - Genetic Analysis - Genetic MicroSystems - Genome Therapeutics - Genometrix - GenVec - Gonorrhea - ImClone Systems - Immunomedics - Incyte Pharmaceuticals - Interferon-Gamma - Influenza Vaccines - IntraBiotics - Invitrogen - Matritech - Mayo Foundation - Medarex - Metra - Monoclonal Antibodies - Monsanto - Myocardial Infarction - Myriad Genetics - Nabi - Neurogen - Neuropeptide Y - New Horizons Diagnostics - NeXstar - NIH - Novartis - Obesity - Organon Teknika - Perkin- Elmer - Pfizer - Pharmacogenetics - Phytera - Ramoplanin - Recombinant Proteins - Ring-Expanded Nucleotides - Rockefeller University - Schering-Plough - Sheffield Pharmaceuticals - Soane Biosciences - T-Cell Receptors - Takara Shuzo - The University of Texas - Thromboembolic Disease - TMT Gene - University of Arizona - University of California - University of Florida - University of Maryland - Variagenics - Wyeth-Lederle Vaccine Division - Xenomatrix - XenoMouse - Xoma ». Biotechnology Law Report 17, n^o 4 (juillet 1998) : 549–55. http://dx.doi.org/10.1089/blr.1998.17.549.

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Thèses sur le sujet "Xenomatrix"

TODESCHINI, GIOVANNI. « Nuova tecnica per la rigenerazione dei tessuti : valutazioni istologiche ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/87297.

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Scopo L’obiettivo dello studio è stato quello di valutare l’efficacia di una nuova tecnica per il mantenimento dei volumi della cresta ossea e la rigenerazione dei tessuti molli con biomateriali. I risultati istologici sono stati messi a confronto con quelli di una guarigione spontanea. Materiali e metodi E’ stato selezionato un paziente che necessitava dell’estrazione di due elementi dentari mandibolari (premolari o molari) e successivo inserimento implantare. Nel sito Test è stata attuata una terapia di preservazione dell’alveolo utilizzando granuli di osso corticale e spongioso in associazione a due strati Xenomatrix (Bioteck s.p.a. Arcugnano, Vicenza - Italy). Un mese dopo la prima estrazione, è stata effettuata la seconda estrazione (sito Controllo), lasciata guarire spontaneamente. A tre mesi da ogni estrazione è stato possibile inserire gli impianti prelevando il tessuto bioptico da analizzare. La tecnica di preservazione prevedeva: lo scollamento del bordo alveolare, il riempimento del sito con biomateriale eterologo, il successivo posizionamento di due sigilli di Xenomatrix con ancoraggio sotto periostale e sutura. In entrambi i casi gli alveoli sono stati fatti guarire appositamente per seconda intenzione. Risultati L’innesto appare integrato e non vi è evidenza di alcuna cellula infiammatoria o cellule di reazione da corpo estraneo a livello del sito rigenerato. Conclusioni L’innesto appare integrato e non vi è evidenza di alcuna cellula infiammatoria. Nel sito rigenerato vi è una migliore compartimentalizzazione dei tessuti.

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