Littérature scientifique sur le sujet « WhiB6 »
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Articles de revues sur le sujet "WhiB6"
Alhadlaq, Meshari Ahmed, Jeffrey Green et Bassam K. Kudhair. « Analysis of Kytococcus sedentarius Strain Isolated from a Dehumidifier Operating in a University Lecture Theatre : Systems for Aerobic Respiration, Resisting Osmotic Stress, and Sensing Nitric Oxide ». Microbial Physiology 31, no 2 (2021) : 135–45. http://dx.doi.org/10.1159/000512751.
Texte intégralGeiman, Deborah E., Tirumalai R. Raghunand, Nisheeth Agarwal et William R. Bishai. « Differential Gene Expression in Response to Exposure to Antimycobacterial Agents and Other Stress Conditions among Seven Mycobacterium tuberculosis whiB-Like Genes ». Antimicrobial Agents and Chemotherapy 50, no 8 (août 2006) : 2836–41. http://dx.doi.org/10.1128/aac.00295-06.
Texte intégralBosserman, Rachel E., Tiffany T. Nguyen, Kevin G. Sanchez, Alexandra E. Chirakos, Micah J. Ferrell, Cristal R. Thompson, Matthew M. Champion, Robert B. Abramovitch et Patricia A. Champion. « WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop inMycobacterium marinum ». Proceedings of the National Academy of Sciences 114, no 50 (27 novembre 2017) : E10772—E10781. http://dx.doi.org/10.1073/pnas.1710167114.
Texte intégralMurarka, Pooja, Aditi Keshav, Bintu Kumar Meena et Preeti Srivastava. « Functional characterization of the transcription regulator WhiB1 from Gordonia sp. IITR100 ». Microbiology 166, no 12 (1 décembre 2020) : 1181–90. http://dx.doi.org/10.1099/mic.0.000985.
Texte intégralRaghunand, Tirumalai R., et William R. Bishai. « Mapping Essential Domains of Mycobacterium smegmatis WhmD : Insights into WhiB Structure and Function ». Journal of Bacteriology 188, no 19 (1 octobre 2006) : 6966–76. http://dx.doi.org/10.1128/jb.00384-06.
Texte intégralVijayaraj, Mahalakshmi. « Virtual screening of a MDR-TB WhiB6 target identified by gene expression profiling ». Bioinformation 15, no 8 (31 août 2019) : 557–67. http://dx.doi.org/10.6026/97320630015557.
Texte intégralAgarwal, Nisheeth, Tirumalai R. Raghunand et William R. Bishai. « Regulation of the expression of whiB1 in Mycobacterium tuberculosis : role of cAMP receptor protein ». Microbiology 152, no 9 (1 septembre 2006) : 2749–56. http://dx.doi.org/10.1099/mic.0.28924-0.
Texte intégralWan, Tao, Shanren Li, Daisy Guiza Beltran, Andrew Schacht, Lu Zhang, Donald F. Becker et LiMei Zhang. « Structural basis of non-canonical transcriptional regulation by the σA-bound iron-sulfur protein WhiB1 in M. tuberculosis ». Nucleic Acids Research 48, no 2 (6 décembre 2019) : 501–16. http://dx.doi.org/10.1093/nar/gkz1133.
Texte intégralChen, Zhenkang, Yangbo Hu, Bridgette M. Cumming, Pei Lu, Lipeng Feng, Jiaoyu Deng, Adrie J. C. Steyn et Shiyun Chen. « Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish ». Cell Reports 16, no 9 (août 2016) : 2512–24. http://dx.doi.org/10.1016/j.celrep.2016.07.080.
Texte intégralCasonato, Stefano, Axel Cervantes Sánchez, Hirohito Haruki, Monica Rengifo González, Roberta Provvedi, Elisa Dainese, Thomas Jaouen et al. « WhiB5, a Transcriptional Regulator That Contributes to Mycobacterium tuberculosis Virulence and Reactivation ». Infection and Immunity 80, no 9 (25 juin 2012) : 3132–44. http://dx.doi.org/10.1128/iai.06328-11.
Texte intégralThèses sur le sujet "WhiB6"
Bonnet, Isabelle. « Rôle de whiB6 et kdpDE dans le clone MDR hypertransmissible B0/W148 de Mycobacterium tuberculosi ». Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS478.pdf.
Texte intégralTuberculosis (TB) is, excluding COVID, the leading cause of death linked to an infectious agent. Rapid determination of the full resistance profile of Mycobacterium tuberculosis (Mtb) is essential to initiate appropriate treatment of multidrug resistant (MDR) cases, thereby limiting the acquisition of additional resistance, increasing the chances of therapeutic success and reducing transmission of these strains. There are 9 main lineages within the M. tuberculosis complex, 2 of which are widespread throughout the world (L2 and L4). Within lineage 2, the clone W148 (or clonal complex CC 100-32) has recently spread to Europe and Asia. This spread could be explained by specific mutations within the genome.First, we investigated the Deeplex Myc-TB tool for rapid detection of genotype and resistance in clinical Mtb MDR strains. The Deeplex Myc-TB technology, based on multiplex PCR and high-throughput sequencing, determines species (hsp65), genotype (spoligotype) and resistance to 13 first- and second-line anti-tuberculosis drugs (18 targets). Our evaluation included 112 samples and 94 strains sent to the Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux (CNR MyRMA). We have observed that the Deeplex Myc-TB test is efficient on microscopically positive samples and strains. The resistance profiles obtained are 85.4% concordant with the results of the phenotypic reference method. The use of Deeplex Myc-TB provides results within ten days, and around 6 weeks before those of the phenotypic antibiogram. Deeplex Myc-TB can therefore be used to adapt antibiotic therapy much earlier than was previously possible, to the patient benefit. We were thus able to validate this tool, which is now routinely used at CNR MyRMA. We next studied mutations specific to CC 100-32 MDR. Genome-wide analysis of 36 strains received at CNR MyRMA identified 30 non-synonymous mutations and small deletions specific to CC 100-32 MDR strains. Among these, we chose to study mutations present in kdpD and whiB6, as data in the literature indicated an impact of these genes on the virulence of the strain. On the one hand, KdpDE is a two-component system regulating expression of the inducible potassium transport system KdpFABC. The mutation present in the CC 100-32 MDR complex is a 2-nucleotides deletion at the end of the kdpD gene, resulting in a KdpDE fusion protein. We therefore constructed such a mutant in Mtb H37Rv by deleting both the kdpD and kdpE genes before complementing it with the wild-type or mutated form of kdpDE. We observed no difference in the in vitro growth of the different strains, even in the absence of potassium, suggesting that KdpDE is not essential for bacterial fitness in presence or absence of potassium. The impact of the deletion on transcriptional activity and virulence is currently being studied. On the other hand, WhiB6 is a transcription factor that regulates the ESX-1 system, necessary for virulence. Work from the laboratory generated a ∆whiB6 mutant and the complemented WT and mutated (T51P) strains and their re-analysis indicated that T51P mutant strain produces less ESAT-6 and pro-inflammatory cytokines than the wild-type strain. Our transcriptome analysis of these strains is currently underway. Initial results suggest that the T51P mutation in WhiB6 results in less virulence and inflammation. This work has validated a tool that is now essential for routine diagnosis of MDR TB at CNR MyRMA, and to study the spread of an MDR clone through the function of two transcription factors involved in virulence
Kudhair, Bassam. « Structural and biochemical studies of Mycobacterium tuberculosis WhiB1 ». Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/18294/.
Texte intégralSmith, L. « Characterisation of the essential transcription factor, WhiB1, from Mycobacterium tuberculosis ». Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3222/.
Texte intégralBurian, Ján. « Characterization of the transcriptional regulator WhiB7 establishes a link between metabolism and intrinsic antibiotic resistance in mycobacteria ». Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52831.
Texte intégralScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Ng, Carol Ka Lo. « Role of aspartate aminotransferases AspB and AspC in the WhiB7-controlled intrinsic drug resistance system of mycobacteria ». Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43552.
Texte intégralOh, Se-Hoon. « Development of efficient systems for integrative transformation of Streptomyces coelocolor A3(2) and their use in molecular analysis of whiB ». Thesis, University of East Anglia, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267528.
Texte intégralZilber, Rachelle Eliza. « Characterisation of a Mycobacterium marinum whiB4 mutant ». 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=789043&T=F.
Texte intégralLeung, Andrea. « Genetic Factors Influencing BCG Vaccine Properties ». Thesis, 2010. http://hdl.handle.net/1807/25756.
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