Articles de revues : « WBH »

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Robins, H. I., D. Rushing, M. Kutz, K. D. Tutsch, C. L. Tiggelaar, D. Paul, D. Spriggs et al. « Phase I clinical trial of melphalan and 41.8 degrees C whole-body hyperthermia in cancer patients. » Journal of Clinical Oncology 15, n^o 1 (janvier 1997) : 158–64. http://dx.doi.org/10.1200/jco.1997.15.1.158.

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PURPOSE To evaluate the biologic interactions and toxicities of melphalan (L-PAM) combined with 41.8 degrees C whole-body hyperthermia (WBH) for 60 minutes. PATIENTS AND METHODS Sixteen patients with refractory cancer were treated (May 1992 to May 1995) with WBH alone during week 1) thereafter patients were randomized to receive either L-PAM alone on week 2 and L-PAM plus WBH on week 5, or the reverse sequence. Patients who demonstrated clinical improvement received WBH plus L-PAM monthly. Dose levels of L-PAM were 10 mg/m2 (n = 3), 15 mg/m2 (n = 3), 17.5 mg/m2 (n = 6), and 20 mg/m2 (n = 4). L-PAM was administered at target temperature; WBH was administered with an Aquatherm radiant-heat device (patent pending; Cancer Research Institute, New York, NY). RESULTS Comparisons of mean WBC count and platelet nadirs for L-PAM alone and L-PAM plus WBH demonstrated that the addition of WBH resulted in nadir counts that were, on average, 25% lower. There were no instances of febrile neutropenia or bleeding. Toxicities allowed for escalation of L-PAM to 20 mg/m2; all four patients at this level experienced grade 4 myelosuppression. No significant myelosuppression was observed at 10 and 15 mg/m2. Grade 3 myelosuppression was observed in two of six patients at 17.5 mg/m2. Responses included complete remission (CR) of pancreatic cancer (10 mg/m2), partial remission (PR) of malignant melanoma in two patients (20 mg/m2), and transient clinical and/or serologic improvement in five patients. The pharmacokinetics of L-PAM were not altered by WBH. Observed cytokine induction by WBH is also discussed in detail. CONCLUSION We conclude that L-PAM with 41.8 degrees C WBH is well tolerated. Clinical results are consistent with preclinical predictions and provide a foundation for second-generation trials now in progress.

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Robins, H. I., J. D. Cohen, C. L. Schmitt, K. D. Tutsch, C. Feierabend, R. Z. Arzoomanian, D. Alberti, F. d'Oleire, W. Longo et C. Heiss. « Phase I clinical trial of carboplatin and 41.8 degrees C whole-body hyperthermia in cancer patients. » Journal of Clinical Oncology 11, n^o 9 (septembre 1993) : 1787–94. http://dx.doi.org/10.1200/jco.1993.11.9.1787.

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PURPOSE To evaluate the biologic interactions and toxicities of carboplatin combined with 41.8 degrees C whole-body hyperthermia (WBH) for 60 minutes in a phase I clinical trial. PATIENTS AND METHODS Thirty assessable patients with cancer refractory to conventional therapy were treated. During induction therapy, patients received WBH alone in week 1, WBH plus carboplatin in week 2, and carboplatin alone in week 5. Carboplatin dose was escalated (three patients per group) as follows: 100, 150, 200, 250, 300, 350, 400, 480, and 575 mg/m2; three additional patients were entered at 480 mg/m2. Carboplatin was administered at target temperature. RESULTS Comparisons of the mean/median WBC and platelet nadirs for carboplatin alone and carboplatin plus WBH demonstrated no enhancing effect by WBH. Toxicities including nausea and/or vomiting, as well as myelosuppression, were within acceptable limits, allowing for escalation to a dose of 575 mg/m2; three of three patients at this dose level experienced grade 4 myelosuppression with no associated infection or bleeding. No renal toxicity was observed. Analysis of platinum in plasma ultrafiltrate and urine showed only slight effects of WBH on the pharmacokinetics and renal excretion of platinum. Responses included the following: lung--minor response (200 mg/m2); gastrointestinal neuroendocrine--complete response (CR) (400 mg/m2); pancreatic--partial response (PR) (480 mg/m2); small bowel--PR (575 mg/m2); ovarian--CR, two patients (575 mg/m2), with marker data suggesting WBH enhancement of carboplatin cytotoxicity. Another three patients experienced clinical improvement after WBH plus carboplatin, but progression with carboplatin alone (lung, 400 mg/m2; gastrointestinal neuroendocrine, 480 mg/m2; melanoma, 480 mg/m2). CONCLUSION We conclude that carboplatin with WBH is well tolerated even at conventional carboplatin doses. Clinical results are consistent with preclinical predictions of an increased therapeutic index for this combination, which encourages future clinical studies.

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Borloo, Noor, Anne Smits, Liesbeth Thewissen, Pieter Annaert et Karel Allegaert. « Creatinine Trends and Patterns in Neonates Undergoing Whole Body Hypothermia : A Systematic Review ». Children 8, n^o 6 (4 juin 2021) : 475. http://dx.doi.org/10.3390/children8060475.

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Many neonates undergoing whole body hypothermia (WBH) following moderate to severe perinatal asphyxia may also suffer from renal impairment. While recent data suggest WBH-related reno-protection, differences in serum creatinine (Scr) patterns to reference patterns were not yet reported. We therefore aimed to document Scr trends and patterns in asphyxiated neonates undergoing WBH and compared these to centiles from a reference Scr data set of non-asphyxiated (near)term neonates. Using a systematic review strategy, reports on Scr trends (mean ± SD, median or interquartile range) were collected (day 1–7) in WBH cohorts and compared to centiles of an earlier reported reference cohort of non-asphyxia cases. Based on 13 papers on asphyxia + WBH cases, a pattern of postnatal Scr trends in asphyxia + WBH cases was constructed. Compared to the reference 50th centile Scr values, mean or median Scr values at birth and up to 48 h were higher in asphyxia + WBH cases with a subsequent uncertain declining trend towards, at best, high or high–normal creatinine values afterwards. Such patterns are valuable for anticipating average changes in renal drug clearance but do not yet cover the relevant inter-patient variability observed in WBH cases, as this needs pooling of individual Screa profiles, preferably beyond the first week of life.

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Krnjajic, Davor, Dustin R. Allen, Cory L. Butts et David M. Keller. « Carotid baroreflex control of heart rate is enhanced, while control of mean arterial pressure is preserved during whole body heat stress in young healthy men ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 311, n^o 4 (1 octobre 2016) : R735—R741. http://dx.doi.org/10.1152/ajpregu.00152.2016.

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Whole body heat stress (WBH) results in numerous cardiovascular alterations that ultimately reduce orthostatic tolerance. While impaired carotid baroreflex (CBR) function during WBH has been reported as a potential reason for this decrement, study design considerations may limit interpretation of previous findings. We sought to test the hypothesis that CBR function is unaltered during WBH. CBR function was assessed in 10 healthy male subjects (age: 26 ± 3; height: 185 ± 7 cm; weight: 82 ± 10 kg; BMI: 24 ± 3 kg/m2; means ± SD) using 5-s trials of neck pressure (+45, +30, and +15 Torr) and neck suction (−20, −40, −60, and −80 Torr) during normothermia (NT) and passive WBH (Δ core temp ∼1°C). Analyses of stimulus response curves (four-parameter logistic model) for CBR control of heart rate (CBR-HR) and mean arterial pressure (CBR-MAP), as well as separate two-way ANOVA of the hypotensive and hypertensive stimuli (factor 1: thermal condition, factor 2: chamber pressure), were performed. For CBR-HR, maximal gain was increased during WBH (−0.73 ± 0.11) compared with NT (−0.39 ± 0.04, mean ± SE, P = 0.03). In addition, the CBR-HR responding range was increased during WBH (33 ± 5) compared with NT (19 ± 2 bpm, P = 0.03). Separate analysis of hypertensive stimulation revealed enhanced HR responses during WBH at −40, −60, and −80 Torr (condition × chamber pressure interaction, P = 0.049) compared with NT. For CBR-MAP, both logistic analysis and separate two-way ANOVA revealed no differences during WBH. Therefore, in response to passive WBH, CBR control of heart rate (enhanced) and arterial pressure (no change) is well preserved.

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Sheppard, Stephanie Rosenbloom, Sameer Desale et Kabir Abubakar. « Respiratory and Hemodynamic Changes in Neonates with Hypoxic–Ischemic Encephalopathy during and after Whole-Body Hypothermia ». American Journal of Perinatology 38, n^o 01 (14 août 2019) : 037–43. http://dx.doi.org/10.1055/s-0039-1694730.

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Abstract Objective This study aimed to determine the degree to which whole-body hypothermia (WBH) impacts hemodynamic and respiratory status during hypothermia and the subsequent rewarming period in neonates with hypoxic–ischemic encephalopathy (HIE). Study Design This is a retrospective study reviewing the medical records of infants treated with WBH. Data including oxygenation index (OI), ventilator efficiency index (VEI), fraction of inspired oxygen (FiO2), blood lactate level, heart rate (HR), and mean blood pressure (MBP) were collected from defined time points from the beginning, middle, and end of WBH and then every 2 hours from the beginning of rewarming for 14 hours thereafter. The analysis included 65 infants. Data were analyzed using a piecewise linear regression with a mixed-effect model. Results HR decreased during WBH and significantly increased during rewarming. Lactate level, OI, VEI, FiO2, and MBP all decreased during WBH but showed no significant change during and after rewarming. Conclusion There was a decrease in metabolic demand as measured by oxygen requirement, OI, HR, and MBP during WBH, but only HR increased during rewarming, with no significant change in the other parameters. Some of this effect may be explained by improvement in the respiratory condition over time.

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Liu, Rui, Min Wang et Jin-Ao Duan. « Antipyretic and Antioxidant Activities of the Aqueous Extract of Cornu Bubali (Water Buffalo Horn) ». American Journal of Chinese Medicine 38, n^o 02 (janvier 2010) : 293–306. http://dx.doi.org/10.1142/s0192415x10007853.

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Cornu Bubali (water buffalo horn, WBH) is an animal-derived product which is widely used in Traditional Chinese Medicine (TCM) for dispelling heat, relieving convulsions and cooling blood. The purpose of this study was to investigate the antipyretic activity of WBH aqueous extract and its potential mechanism. Two hyperthermia models, yeast-induced (infectious) and skimmed milk-induced (noninfectious) hyperthermia were employed to evaluate the antipyretic effect and the results showed that rectal temperature of hyperthermia animals was decreased significantly after oral administration of WBH extract. The production of tumor necrosis factor-α (TNF-α)-induced prostaglandin E2 (PGE2) in rat cerebral microvascular endothelial cells (rCMECs) was inhibited by WBH extract in the concentrations of 10 μg/ml and 100 μg/ml. The WBH extract protected rCMECs survival from hydrogen peroxide ( H2O2 )-induced toxicity and inhibited the H2O2 -induced leakage of lactate dehydrogenase (LDH) enzyme release at a dose ranging from 5 μg/ml to 100 μg/ml. It could also increase the superoxide dismutase (SOD) and catalase (CAT) enzyme activities. The results suggest that Cornu Bubali exhibits antipyretic activity on both infectious and noninfectious hyperthermia. The antipyretic activity of WBH may be due to the effects on enhancing antioxidation enzyme activities, decreasing PGE2 production, and protecting the rCMECs against H2O2 -induced injury.

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Cui, Jian, Zhaohui Gao, Cheryl Blaha, Jonathan Carter Luck, Kristen Brandt et Lawrence I. Sinoway. « Moderate whole body heating attenuates the exercise pressor reflex responses in older humans ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 320, n^o 5 (1 mai 2021) : R757—R769. http://dx.doi.org/10.1152/ajpregu.00232.2020.

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Prior reports show that whole body heat stress attenuates the pressor response to exercise in young healthy subjects. The effects of moderate whole body heating (WBH; e.g., increase in internal temperature Tcore of ∼0.4°C–0.5°C) or limb heating on sympathetic and cardiovascular responses to exercise in older healthy humans remain unclear. We examined the muscle sympathetic nerve activity (MSNA), mean arterial blood pressure (MAP), and heart rate (HR) in 14 older (62 ± 2 yr) healthy subjects during fatiguing isometric handgrip exercise and postexercise circulatory occlusion (PECO). The protocol was performed under normothermic, moderate WBH, and local limb (i.e., forearm) heating conditions during three visits. During the mild WBH stage (increase in Tcore of <0.3°C), HR increased, whereas BP and MSNA decreased from baseline. Under the moderate WBH condition (increase in Tcore of ∼0.4°C), BP decreased, HR increased, and MSNA was unchanged from baseline. Compared with the normothermic trial, the absolute MAP during fatiguing exercise and PECO was lower during the WBH trial. Moreover, MSNA and MAP responses (i.e., changes) to fatiguing exercise were also less than those seen during the normothermic trial. Limb heating induced a similar increase in forearm muscle temperature to that seen in the WBH trial (∼0.7°C–1.5°C). Limb heating did not alter resting MAP, HR, or MSNA. The MSNA and hemodynamic responses to exercise in the limb heating trial were not different from those in the normothermic trial. These data suggest that moderate WBH attenuates MSNA and BP responses to exercise in older healthy humans.

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Dominic J, Sturm, Kunz Christoph, Peteinatos Gerassimos et Gerhards Roland. « Do cover crop sowing date and fertilization affect field weed suppression ? » Plant, Soil and Environment 63, No. 2 (7 mars 2017) : 82–88. http://dx.doi.org/10.17221/1/2017-pse.

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The weed suppressive ability of oilseed radish (Raphanus sativus var. oleiformis Pers.) cover crop is attributed to high competitiveness for resources and biochemical effects on weeds. The oilseed radish cover crop was sown in five treatments plus an untreated control over a period of five weeks before and three weeks after winter wheat harvest. Additionally, fertilization effects on oilseed radish biomass and weed suppression were measured. The highest biomass of the cover crop was observed 12 weeks after harvest (WAH) when the oilseed radish was sown one week after harvest (1 WAH) (2015) and five weeks before harvest (5 WBH) (2016). No differences of fertilization were observed concerning oilseed radish and weed biomass in 2015, whereby increased biomass was found after fertilization in 2016. The highest weed control efficacy of up to 83% and 90% was achieved in treatments 1 WAH (2015) and 5 WBH (2016) at 12 WAH. The early sowing of oilseed radish in winter wheat resulted in low germination and biomass yield within the field, due to low precipitation in 2015. Nevertheless, there is a high potential of early sown oilseed radish for higher weed control efficacy, which was demonstrated in 2016.

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Khanlarian, Cynthia J., et Rahul Singh. « An Exploratory Study of the Online Learning Environment ». Issues in Accounting Education 29, n^o 1 (1 septembre 2013) : 117–47. http://dx.doi.org/10.2308/iace-50614.

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ABSTRACT Web-based homework (WBH) is an increasingly important phenomenon. There is little research about its character, the nature of its impact on student performance, and how that impact evolves over an academic term. The primary research questions addressed in this study are: What relevant factors in a WBH learning environment impact students' performance? And how does the impact of these factors change over the course of an academic term? This paper examines and identifies significant factors in a WBH learning environment and how they impact student performance. We studied over 300 students using WBH extensively for their coursework, throughout a semester in an undergraduate class at a large public university. In this paper, we present factors in the WBH learning environment that were found to have a significant impact on student performance during the course of a semester. In addition to individual and technological factors, this study presents findings that demonstrate that frustration with IT use is a component of the learning environment, and as a construct, has a larger impact than usefulness on student performance at the end of a course. Our results indicate that educators may benefit from training students and engaging them in utility of co-operative learning assignments to mitigate the level of frustration with the software in the WBH learning environment and improve student performance.

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Langhorst, Jost, Anna K. Koch, Christina Kehm, Özlem Öznur, Harald Engler et Winfried Häuser. « Mild Water-Filtered Infrared-A Whole-Body Hyperthermia Reduces Pain in Patients with Fibromyalgia Syndrome—A Randomized Sham-Controlled Trial ». Journal of Clinical Medicine 12, n^o 8 (18 avril 2023) : 2945. http://dx.doi.org/10.3390/jcm12082945.

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The challenging treatment situation of patients with fibromyalgia syndrome (FMS) requires additional therapy options. The effects of water-filtered infrared-A whole-body hyperthermia (WBH) versus sham hyperthermia on pain intensity were investigated in an outpatient setting within a two-armed randomized sham-controlled trial. n = 41 participants aged between 18 and 70 years with a medically confirmed diagnosis of FMS were randomized to WBH (intervention; n = 21) or sham hyperthermia (control; n = 20). Six treatments with mild water-filtered infrared-A WBH over a period of three weeks with at least one day in between treatments were applied. On average, the maximum temperature was 38.7 °C for a duration of approximately 15 min. The control group received exactly the same treatment except that an insulating foil between the patient and the hyperthermia device blocked most of the radiation. Primary outcome was pain intensity measured by the Brief Pain Inventory at week 4. Secondary outcomes included blood cytokine levels and FMS-related core symptoms and quality of life. Pain intensity at week 4 was significantly different between the groups in favor of WBH (p = 0.015). A statistically significant pain reduction in favor of WBH was also found at week 30 (p = 0.002). Mild water-filtered infrared-A WBH effectively reduced pain intensity at the end of treatment and follow-up.

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Atanackovic, Djordje, Kristina Pollok, Christiane Faltz, Ina Boeters, Roman Jung, Alexander Nierhaus, Klaus-Michael Braumann, Dieter Kurt Hossfeld et Susanna Hegewisch-Becker. « Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, n^o 3 (mars 2006) : R585—R594. http://dx.doi.org/10.1152/ajpregu.00014.2005.

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An activation of the immune system might contribute to the therapeutic effect of whole body hyperthermia (WBH) in cancer patients. We explored immune and endocrine responses in patients undergoing high-temperature WBH. Identical parameters were investigated in a separate group of healthy volunteers undergoing physical exercise to rule out effects of sympathetic activation. Lymphocyte subpopulations, lymphocytic expression of a range of adhesion molecules, and serum concentrations of a variety of hormones and cytokines were assessed in cancer patients undergoing high-temperature (60 min at 41.0–41.8°C) WBH ( n = 25) and in a separate group of healthy volunteers ( n = 10) performing strenuous physical exercise. WBH induced an increase in human growth hormone (hGH), ACTH, and cortisol as well as in TNF-α, IL-6, IL-8, and IL-12R. We observed an increase in natural killer (NK) cells and CD56+ NK T cells shortly after initiation of WBH. In contrast, we found a decrease in T cells expressing l-selectin (CD62L) or α4β7 integrin adhesion molecules mediating homing to lymphatic tissues. Accordingly, we observed a decrease in CD45RA+CCR7+ naive and CD45RA−CCR7+ central memory T cells. Numbers of CD45RA−CCR7− memory effector and CD45RA+CCR7 terminally differentiated T cells, on the other hand, remained unchanged. No comparable changes were observed in the group of healthy volunteers. In conclusion, patients with solid tumors treated with WBH show an increase in NK and NK T cells. In a later phase, plasma concentrations of IL-8, hGH, and cortisol increase, correlated with an influx of neutrophils into the peripheral blood. The alterations in T-cell populations suggest that WBH may induce naive and central-memory T cells to enter lymphatic tissue to await antigen exposure and effector T cells to migrate into peripheral tissues to exert their effector function. Although the exercise group may not be an appropriate control to proof the effect of WBH, these changes were not seen in the healthy volunteers performing physical exercise.

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Izquierdo-Villalba, David, Silvia Bonoli, Massimo Dotti, Alberto Sesana, Yetli Rosas-Guevara et Daniele Spinoso. « From galactic nuclei to the halo outskirts : tracing supermassive black holes across cosmic history and environments ». Monthly Notices of the Royal Astronomical Society 495, n^o 4 (21 mai 2020) : 4681–706. http://dx.doi.org/10.1093/mnras/staa1399.

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ABSTRACT We study the mass assembly and spin evolution of supermassive black holes (BHs) across cosmic time as well as the impact of gravitational recoil on the population of nuclear and wandering BHs (wBHs) by using the semi-analytical model L-Galaxies run on top of Millennium merger trees. We track spin changes that BHs experience during both coalescence events and gas accretion phases. For the latter, we assume that spin changes are coupled with the bulge assembly. This assumption leads to predictions for the median spin values of z = 0 BHs that depend on whether they are hosted by pseudo-bulges, classical bulges or ellipticals, being $\overline{a} \sim 0.9$, 0.7 and 0.4, respectively. The outcomes of the model display a good consistency with $z \le 4$ quasar luminosity functions and the $z = 0$ BH mass function, spin values, and BH correlation. Regarding the wBHs, we assume that they can originate from both the disruption of satellite galaxies (orphan wBH) and ejections due to gravitational recoils (ejected wBH). The model points to a number density of wBHs that increases with decreasing redshift, although this population is always $\rm {\sim}2\, dex$ smaller than the one of nuclear BHs. At all redshifts, wBHs are typically hosted in $\rm {\it M}_{halo} \gtrsim 10^{13} \, M_{\odot }$ and $\rm {\it M}_{stellar} \gtrsim 10^{10} \, M_{\odot }$, being orphan wBHs the dominant type. Besides, independently of redshift and halo mass, ejected wBHs inhabit the central regions (${\lesssim}\rm 0.3{\it R}_{200}$) of the host DM halo, while orphan wBH linger at larger scales (${\gtrsim}\rm 0.5{\it R}_{200}$). Finally, we find that gravitational recoils cause a progressive depletion of nuclear BHs with decreasing redshift and stellar mass. Moreover, ejection events lead to changes in the predicted local BH–bulge relation, in particular for BHs in pseudo-bulges, for which the relation is flattened at $\rm {\it M}_{bulge} \gt 10^{10.2}\, M_{\odot }$ and the scatter increase up to ${\sim}\rm 3\, dex$.

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Brandhorst, H., M. Olbrich, A. Neumann, H. Jahr et D. Brandhorst. « Effect of Pretransplant Preconditioning by Whole Body Hyperthermia on Islet Graft Survival ». Cell Transplantation 16, n^o 7 (août 2007) : 707–15. http://dx.doi.org/10.3727/000000007783465163.

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Previous observations in heat-shocked pig islets revealed the ambivalent character of the stress response simultaneously inducing processes of protection and apoptosis. To clarify whether the proapoptotic character of the stress response is reduced in heat-exposed islets still embedded in their native environment, hyperthermia was performed in the present study either as whole body hyperthermia (WBH) prior to pancreas resection or as in vitro heat shock (HS) after isolation. HS (42°C/45 min) was induced in donors 12 h before isolation (WBH, n = 32) or in freshly isolated islets prior to 12 h of culture at 37°C (in vitro HS, n = 25). Islets continuously incubated at 37°C served as controls (n = 34). Proinflammatory treatment was performed with H2O2, DETA-NO, or a combination of IL-1β, TNF-α, and IFN-γ. Quality assessment included islet yield, viability staining, static glucose incubation, and nude mouse transplantation. WBH was significantly less effective than in vitro HS to induce HSP70 overexpression and to increase islet resistance against inflammatory mediators. Although characterized by an unaltered Bax to Bcl-2 ratio, islets subjected to WBH partially failed to restore sustained normoglycemia in diabetic nude mice. The inflammatory response observed in the pancreas of WBH-treated rats was associated with significantly reduced viability that seems to have a higher predictive value for posttransplant outcome compared to islet in vitro function or mitochondrial activity. In contrast, in vitro HS significantly decreased transcript levels of Bcl-2, but did not affect posttransplant function compared to sham-treated islets. These findings suggest that WBH is primarily associated with increased necrosis as a secondary tissue type-specific effect of pancreas damage while in vitro HS mainly induces apoptosis.

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Zalewski, D., A. Nobis, E. Dąbrowska et N. Waszkiewicz. « The use of light, temperature and pressure in the treatment of depression ». European Psychiatry 64, S1 (avril 2021) : S740. http://dx.doi.org/10.1192/j.eurpsy.2021.1961.

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IntroductionClimate and weather have a great influence on the prevalence of depressive disorders. Selected physical parameters for instance light, temperature and pressure can be used to treat mood disorders.ObjectivesThe present mini-review aims at approximating the mechanisms by which selected, strictly controlled physical parameters in particular light, temperature, and oxygen pressure can help in the treatment of depression and determine their potential effectiveness.MethodsRelevant literature was identified by searching the PubMed/Medline database, by combining the search strategy of free text terms and exploding a range of MESH headings relating to the topics.ResultsMechanisms that can modify the course of depression were briefly presented. Review of the literature showed the well-established position of bright light therapy (BLT) effective in treating seasonal (SAD) and non-seasonal affective disorders (non-SAD); safety and rapid-action of whole-body hyperthermia (WBH) and whole-body cryotherapy (WBC) were also demonstrated; the least data was available on hyperbaric oxygen therapy (HBOT), which had antidepressant properties only in people with concomitant neurological damages.ConclusionsIn addition to the well-established position of BLT in the treatment of depression, further research is needed on other methods, such as WBH, WBC, HBOT.DisclosureNo significant relationships.

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Schupp, James R., et Duane W. Greene. « Effect of Aminoethoxyvinylglycine (AVG) on Preharvest Drop, Fruit Quality, and Maturation of `McIntosh' Apples. I. Concentration and Timing of Dilute Applications of AVG ». HortScience 39, n^o 5 (août 2004) : 1030–35. http://dx.doi.org/10.21273/hortsci.39.5.1030.

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To compare the effects of growth regulators on preharvest fruit drop and fruit maturity, aminoethoxyvinylglycine (AVG) was applied to `McIntosh' apple trees at 75, 150, or 225 mg·L-1, at 8, 4, or 2 weeks before harvest (WBH). These treatments were compared to NAA, daminozide, and to an untreated control. All AVG treatments and timings except 75 mg·L-1 applied 8 WBH delayed preharvest drop and fruit maturity. AVG applied at 225 mg·L-1was more effective in delaying drop and development of maturity than other rates when applied 8 or 2 WBH, but at 4 WBH, 150 mg·L-1 gave equivalent results to 225 mg·L-1. AVG at 150 mg·L-1 was superior to NAA or daminozide as a stop-drop agent. No concentration, or time of application of AVG influenced fruit size at harvest. AVG reduced internal ethylene concentration (IEC) in `McIntosh' apples linearly with increasing AVG concentration. There was a linear relationship between time of AVG application (8, 4, or 2 WBH) and IEC in the fruit after harvest, and the time required for harvested fruit to enter the ethylene climacteric. Development of red color was delayed by AVG. This was attributed to a delay in ripening as determined by a slower increase in IEC and starch hydrolysis. In general, earlier application of AVG resulted in reduced effectiveness of lowering IEC following harvest. Chemical names used: aminoethoxyvinylglycine (AVG), naphthaleneacetic acid (NAA), succinic acid-2,2-dimethylhydrazide (daminozide).

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Öznur, Özlem, Christoph Schlee, Sandra Utz et Jost Langhorst. « Investigating the Influential Factors of Mild Water-Filtered Infrared-A Whole-Body Hyperthermia for Pain Relief in Fibromyalgia : A Mixed-Methods Approach Focusing on Predictors and Patient Perspectives ». Biomedicines 11, n^o 11 (1 novembre 2023) : 2949. http://dx.doi.org/10.3390/biomedicines11112949.

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Fibromyalgia syndrome (FMS) is a chronic condition characterized by chronic widespread pain, persistent fatigue, and disrupted sleep, significantly impacting well-being. Mild water-filtered infrared-A (wIRA) whole-body hyperthermia (WBH) is emerging as a promising pain management approach to FMS. Within the present randomized controlled trial (ClinicalTrials ID: NCT05135936), FMS patients underwent six sessions of mild wIRA-WBH over 3 weeks. Their pain levels were assessed at baseline and at week 12, while body core temperature and plateau phase duration were monitored during WBH. Qualitative interviews were conducted at week 12. Results from this mixed-methods study revealed that baseline pain intensity and plateau phase duration significantly predicted pain intensity at week 12. Thematic analysis of the interviews revealed diverse patient experiences with the treatment, with all patients reporting improvements in perceived pain and overall well-being. The onset and duration of pain relief varied among individuals. Overall, the findings suggest that the duration of the plateau phase may serve as an indicator for long-term pain reduction, although individual factors may influence treatment outcomes. Despite varying experiences, a prevailing trend of positive patient evaluations emerged. This study sheds light on the potential of wIRA-WBH as a therapeutic option for alleviating pain for and enhancing the well-being of FMS patients.

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Farrell, D. M., et V. S. Bishop. « Permissive role for nitric oxide in active thermoregulatory vasodilation in rabbit ear ». American Journal of Physiology-Heart and Circulatory Physiology 269, n^o 5 (1 novembre 1995) : H1613—H1618. http://dx.doi.org/10.1152/ajpheart.1995.269.5.h1613.

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The present study was designed to test the hypothesis that during whole body heating (WBH), nitric oxide (NO) synthesized in the endothelium acts synergistically with an unknown neurotransmitter to elicit active vasodilation. Rabbits were instrumented for the measurement of mean arterial pressure, heart rate, and ear blood flow (EBF) (Doppler ultrasound). During WBH, either N omega-nitro-L-arginine methyl ester (L-NAME, 10-40 mg over 10-15 min, n = 6 rabbits; group 1), a NO synthase inhibitor, or saponin (30-40 mg over 10-20 min, n = 6 rabbits; group 2), a detergent that denudes the endothelium, was given via a lingual artery catheter until thermoregulatory vasodilation was reversed. When EBF stabilized at the new reduced level, the NO donor, sodium nitroprusside (SNP), was infused (0.2-1.0 mg/ml, 0.01-0.05 ml/min, 2-5 min) via the lingual artery catheter. During WBH, EBF increased from 0.39 +/- 0.08 to 6.47 +/- 0.63 kHz in group 1, and from 0.69 +/- 0.18 to 5.72 +/- 0.49 kHz in group 2. Infusion of L-NAME decreased EBF in group 1 to 1.97 +/- 0.40 kHz. Infusion of saponin decreased EBF in group 2 to 1.23 +/- 0.40 kHz. Subsequent SNP infusion during hyperthermia returned EBF to 6.88 +/- 0.72 kHz in group 1 and 5.53 +/- 1.27 kHz in group 2 but had no effect when administered during normothermia. These results suggest that NO acts in conjunction with another substance, presumably the neurotransmitter released on WBH, to elicit thermoregulatory vasodilation.

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Allen, Dustin R., Mu Huang, Iqra M. Parupia, Ariana R. Dubelko, Elliot M. Frohman et Scott L. Davis. « Impaired sweating responses to a passive whole body heat stress in individuals with multiple sclerosis ». Journal of Neurophysiology 118, n^o 1 (1 juillet 2017) : 7–14. http://dx.doi.org/10.1152/jn.00897.2016.

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Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS), disrupting autonomic function. The aim of this study was to test the hypothesis that individuals with MS have blunted control of thermoregulatory reflex increases in sweat rate (SR) and cutaneous vasodilation compared with controls during a passive whole body heat stress (WBH). Eighteen individuals with relapsing-remitting MS and 18 healthy controls (Con) participated in the study. Core temperature (Tcore), skin temperature, heart rate, arterial blood pressure (10-min intervals), skin blood flow (laser-Doppler flux, LDF), and SR were continuously measured during normothermic baseline (34°C water perfusing a tube-lined suit) and WBH (increased Tcore 0.8°C via 48°C water perfusing the suit). Following WBH, local heaters were warmed to 42°C, inducing peak cutaneous vasodilation at the site of LDF collection. Cutaneous vascular conductance (CVC) was calculated as the ratio of LDF to mean arterial pressure and expressed as a percentage of peak achieved during local heating. Individuals with MS had attenuated SR responses to WBH (ΔSR from baseline: Con, 0.65 ± 0.27; MS, 0.42 ± 0.17 mg·cm−2·min−1, P = 0.003), whereas Δ%CVC42C from baseline was similar between groups (Con, 42 ± 16%; MS, 38 ± 12%, P = 0.39). SR responses were blunted as a function of Tcore in MS (interaction: group × Tcore, P = 0.03), of which differences were evident at ΔTcore 0.7°C and 0.8°C ( P < 0.05). No interaction was observed in Δ%CVC42C. Taken together, the findings show MS blunts sweating responses, whereas control of the cutaneous vasculature is preserved, in response to WBH. NEW & NOTEWORTHY This study is the first to assess the reflex control of the thermoregulatory system in individuals living with multiple sclerosis (MS). The novel findings are twofold. First, attenuated increases in sweat rate in subjects with MS compared with healthy controls were observed in response to a moderate increase (0.8°C) in core temperature via passive whole body heat stress. Second, it appears the reflex control of the cutaneous vasculature is preserved in MS.

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Taylor, W. F., et V. S. Bishop. « A role for nitric oxide in active thermoregulatory vasodilation ». American Journal of Physiology-Heart and Circulatory Physiology 264, n^o 5 (1 mai 1993) : H1355—H1359. http://dx.doi.org/10.1152/ajpheart.1993.264.5.h1355.

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We have shown previously that an increase in ear blood flow velocity (EBF) in the conscious, chronically instrumented rabbit during whole body heating (WBH) involves active neurogenic vasodilation that is abolished by local nerve block. This study was designed to test the potential role of nitric oxide (NO) in rabbit ear neurogenic vasodilation during hyperthermia. Rabbits were instrumented for the measurement of arterial pressure, heart rate, and EBF (Doppler ultrasound). A catheter was also placed in the left lingual artery for administration of drugs to the left ear. WBH was achieved by circulating warm water through a rubber pad placed around the rabbit. Internal temperature was measured with a rectal thermocouple. During WBH, bolus injections of N omega-nitro-L-arginine (L-NNA), a false substrate for the formation of NO, were given via the lingual artery (10(-5) M, 4-5 ml total) to determine whether NO was involved in the increase in EBF. During WBH, left ear vascular conductance (EVC) increased from 0.07 +/- 0.03 to 5.87 +/- 0.73 kHz/100 mmHg and right EVC from 0.20 +/- 0.13 to 4.49 +/- 1.73 kHz/100 mmHg. When EVC was maximum, L-NNA was administered into the left lingual artery. EVC began to decrease after a latency of 23 min. At 56 +/- 8 min, left and right EVC had decreased to 0.18 +/- 0.10 and 0.23 +/- 0.11 kHz/100 mmHg, respectively (P < 0.05). Subsequent infusions of L-arginine, the true substrate for NO formation, restored EVC. These results suggest that NO is involved in active vasodilation during heating in the rabbit ear.

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Tuliński, Arkadiusz. « Oficerowie Biura Historycznego i Wojskowego Biura Historycznego w latach 1922–1939 (część 2) ». Przegląd Historyczno-Wojskowy 21, n^o 2 (2020) : 161–99. http://dx.doi.org/10.32089/wbh.phw.2020.2(272).0006.

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The presented biographical collective study concerns the officers of the Historical Bureau/Military Historical Bureau (BH/WBH). It contains biographical notes on officers serving in BH/WBH in 1922–1939, preceded by a preliminary collective portrait of the officers. The biographical notes were prepared taking into account especially their age, civil education, knowledge of foreign languages, the course of military service, work in headquarters or such entities as military museums or educational institutions. The author’s intention was to concisely present both the dynamic development of the office and the professional level of officers assigned to it.

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Tuliński, Arkadiusz. « Oficerowie Biura Historycznego i Wojskowego Biura Historycznego w latach 1922–1939 (część 1) ». Przegląd Historyczno-Wojskowy 20, n^o 4 (2019) : 157–89. http://dx.doi.org/10.32089/wbh.phw.2019.4(270).0005.

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The presented biographical collective study concerns the officers of the Historical Bureau/Military Historical Bureau (BH/WBH). It contains biographical notes on officers serving in BH/WBH in 1922–1939, preceded by a preliminary collective portrait of the officers. The biographical notes were prepared taking into account especially their age, civil education, knowledge of foreign languages, the course of military service, work in headquarters or such entities as military museums or educational institutions. The author’s intention was to concisely present both the dynamic development of the office and the professional level of officers assigned to it.

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Henríquez-Piskulich, Patricia A., Constanza Schapheer, Nicolas J. Vereecken et Cristian Villagra. « Agroecological Strategies to Safeguard Insect Pollinators in Biodiversity Hotspots : Chile as a Case Study ». Sustainability 13, n^o 12 (14 juin 2021) : 6728. http://dx.doi.org/10.3390/su13126728.

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Industrial agriculture (IA) has been recognized among the main drivers of biodiversity loss, climate change, and native pollinator decline. Here we summarize the known negative effects of IA on pollinator biodiversity and illustrate these problems by considering the case of Chile, a “world biodiversity hotspot” (WBH) where food exports account for a considerable share of the economy in this country. Most of Chile’s WBH area is currently being replaced by IA at a fast pace, threatening local biodiversity. We present an agroecological strategy for sustainable food production and pollinator conservation in food-producing WBHs. In this we recognize native pollinators as internal inputs that cannot be replaced by IA technological packages and support the development of agroecological and biodiversity restorative practices to protect biodiversity. We suggest four fundamental pillars for food production change based on: (1) sharing the land, restoring and protecting; (2) ecological intensification; (3) localized knowledge, research, and technological development; and (4) territorial planning and implementation of socio-agroecological policies. This approach does not need modification of native pollination services that sustain the world with food and basic subsistence goods, but a paradigm change where the interdependency of nature and human wellbeing must be recognized for ensuring the world’s food security and sovereignty.

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Kurpeshev, O. K., et J. Van der Zee. « Hyperthermia in Conservative and Palliative Treatment of Oncological Patients. Part II. Whole Body Hyperthermia ». MEDICAL RADIOLOGY AND RADIATION SAFETY 67, n^o 2 (avril 2022) : 43–58. http://dx.doi.org/10.33266/1024-6177-2022-67-2-43-58.

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The analysis of the results of the use of whole-body hyperthermia (WBH) in patients with locally advanced, recurrent and / or metastatic tumors, which, as a rule, are radio- and chemo-resistant. Most patients were incurable, in connection with which the treatment was mainly carried out with a palliative purpose. The analysis showed that the method alone or in combination with chemo- and radiation therapy has pronounced direct and palliative effects, in some cases it provides long-term control. However, WBH can have side effects. This necessitates further improvement of the method, development of a set of preventive measures, as well as improvement of equipment for heating and thermometry.

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Mason, Ashley E., Sarah M. Fisher, Anoushka Chowdhary, Ekaterina Guvva, Danou Veasna, Erin Floyd, Sean B. Fender et Charles Raison. « Feasibility and acceptability of a Whole-Body hyperthermia (WBH) protocol ». International Journal of Hyperthermia 38, n^o 1 (1 janvier 2021) : 1529–35. http://dx.doi.org/10.1080/02656736.2021.1991010.

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Ogawa, Takahiro, Sven P. Hoekstra, Yoshi-Ichiro Kamijo, Victoria L. Goosey-Tolfrey, Jeremy J. Walsh, Fumihiro Tajima F. et Christof A. Leicht. « Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating ». PLOS ONE 16, n^o 12 (9 décembre 2021) : e0260775. http://dx.doi.org/10.1371/journal.pone.0260775.

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Brain-derived neurotrophic factor (BDNF) plays a key role in neuronal adaptations. While previous studies suggest that whole-body heating can elevate circulating BDNF concentration, this is not known for local heating protocols. This study investigated the acute effects of whole-body versus local passive heating on serum and plasma BDNF concentration. Using a water-perfused suit, ten recreationally active males underwent three 90 min experimental protocols: heating of the legs with upper-body cooling (LBH), whole-body heating (WBH) and a control condition (CON). Blood samples were collected before, immediately after and 1 h post-heating for the determination of serum and plasma BDNF concentration, platelet count as well as the BDNF release per platelet. Rectal temperature, cardiac output and femoral artery shear rate were assessed at regular intervals. Serum and plasma BDNF concentration were elevated after WBH (serum: 19.1±5.0 to 25.9±11.3 ng/ml, plasma: 2.74±0.9 to 4.58±2.0; p<0.044), but not LBH (serum: 19.1±4.7 to 22.3±4.8 ng/ml, plasma: 3.25±1.13 to 3.39±0.90 ng/ml; p>0.126), when compared with CON (serum: 18.6±6.4 to 16.8±3.4 ng/ml, plasma: 2.49±0.69 to 2.82±0.89 ng/ml); accompanied by an increase in platelet count (p<0.001). However, there was no change in BDNF content per platelet after either condition (p = 0.392). All physiological measures were elevated to a larger extent after WBH compared with LBH (p<0.001), while shear rate and rectal temperature were higher during LBH than CON (p<0.038). In conclusion, WBH but not LBH acutely elevates circulating BDNF concentration. While these findings further support the use of passive heating to elevate BDNF concentration, a larger increase in shear rate, sympathetic activity and/or rectal temperature than found after LBH appears needed to induce an acute BDNF response by passive heating.

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Zan, Ming, Zhongming Xu, Linsen Huang et Zhifei Zhang. « A Sound Source Identification Algorithm Based on Bayesian Compressive Sensing and Equivalent Source Method ». Sensors 20, n^o 3 (6 février 2020) : 865. http://dx.doi.org/10.3390/s20030865.

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Near-field acoustic holography (NAH) based on equivalent source method (ESM) is an effective method for identifying sound sources. Conventional ESM focuses on relatively low frequencies and cannot provide a satisfactory solution at high frequencies. So its improved method called wideband acoustic holography (WBH) has been proposed, which has high reconstruction accuracy at medium-to-high frequencies. However, it is less accurate for coherent sound sources at low frequencies. To improve the reconstruction accuracy of conventional ESM and WBH, a sound source identification algorithm based on Bayesian compressive sensing (BCS) and ESM is proposed. This method uses a hierarchical Laplace sparse prior probability distribution, and adaptively adjusts the regularization parameter, so that the energy is concentrated near the correct equivalent source. Referring to the function beamforming idea, the original algorithm with order v can improve its dynamic range, and then more accurate position information is obtained. Based on the simulation of irregular microphone array, comparisons with conventional ESM and WBH show that the proposed method is more accurate, suitable for a wider range of frequencies, and has better reconstruction performance for coherent sources. By increasing the order v, the coherent sources can be located accurately. Finally, the stability and reliability of the proposed method are verified by experiments.

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Hodges, Gary J., Caroline Chiu, Wojciech A. Kosiba, Kun Zhao et John M. Johnson. « The effect of microdialysis needle trauma on cutaneous vascular responses in humans ». Journal of Applied Physiology 106, n^o 4 (avril 2009) : 1112–18. http://dx.doi.org/10.1152/japplphysiol.91508.2008.

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Microdialysis enables in-depth mechanistic study of the cutaneous circulation in humans. However, whether the insertion or presence of the microdialysis fiber (MDF) affects the skin circulation or its responses is unknown. We tested whether the cutaneous vascular response to whole body heating (WBH) was affected by MDF or by pretreatment with ice ( part 1) or local anesthesia (LA; part 2). Eleven subjects participated, 9 in part 1 and 8 in part 2 (5 participated in both). In both parts, four sites on the forearm were selected, providing untreated control, MDF only, ice or LA only, and combined MDF plus ice or LA. A tube-lined suit controlled whole body skin temperature, which was raised to ∼38°C for WBH. Skin sites were instrumented with laser-Doppler flow probes. Data were expressed as cutaneous vascular conductance (CVC). Baseline levels were not different among sites ( P > 0.05). In part 1, the internal temperature for the onset of vasodilation was higher ( P > 0.05) with MDF with or without ice pretreatment than at untreated control sites (control 36.6 ± 0.1°C, Ice 36.5 ± 0.1, MDF 36.8 ± 0.1°C, and Ice+MDF 36.8 ± 0.1°C). Peak CVC during WBH was decreased ( P < 0.05) by MDF (control 73 ± 7 vs. MDF 59 ± 6% of maximal CVC). Ice (73 ± 6% of maximal CVC) or Ice+MDF (69 ± 6% of maximal CVC) did not affect ( P > 0.05) peak CVC compared with control. In part 2, the temperature threshold for the onset of vasodilation was increased by MDF with or without LA treatment and by LA alone ( P < 0.05; control 36.6 ± 0.1°C, MDF 36.7 ± 0.1°C, LA 36.8 ± 0.1°C, and LA+MDF 36.8 ± 0.1°C). Peak CVC was decreased by MDF (control 69 ± 6% of maximal CVC vs. MDF 58 ± 8% of maximal CVC; P < 0.05). LA only (65 ± 10% of maximal CVC) or MDF in the presence of LA (73 ± 12% of maximal CVC) did not affect ( P > 0.05) peak CVC compared with control. Thus LA or MDF increases the temperature threshold for the onset of vasodilation. MDF alone decreases the peak vasodilator response in CVC to WBH; however, this attenuation did not occur if ice or LA is used before MDF placement. Ice or LA alone do not affect the peak response in CVC to WBH. How those treatments prevent or reverse the effect of MDF placement is presently unclear.

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Sokolnicki, Lynn A., Nicholas A. Strom, Shelly K. Roberts, Shirley A. Kingsley-Berg, Ananda Basu et Nisha Charkoudian. « Skin blood flow and nitric oxide during body heating in type 2 diabetes mellitus ». Journal of Applied Physiology 106, n^o 2 (février 2009) : 566–70. http://dx.doi.org/10.1152/japplphysiol.91289.2008.

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Individuals with type 2 diabetes mellitus (T2DM) often exhibit microvascular dysfunction that may contribute to impaired thermoregulation, but potential mechanisms remain unclear. Our goals were to quantify skin blood flow responses and nitric oxide-mediated vasodilation during body heating in individuals with T2DM compared with nondiabetic control subjects of similar age. We measured skin blood flow (laser-Doppler flowmetry) in conjunction with intradermal microdialysis of NG-nitro-l-arginine methyl ester (l-NAME; nitric oxide synthase inhibitor) or vehicle during 45–60 min of whole body heating (WBH) in 10 individuals with T2DM and 14 control subjects. In six individuals from each group, we also measured forearm blood flow (FBF) by venous occlusion plethysmography on the contralateral forearm. FBF responses showed diminished absolute cutaneous vasodilation during WBH in the T2DM group ( PANOVA < 0.01; peak FBF in control 13.1 ± 1.7 vs. T2DM 9.0 ± 1.6 ml·100 ml−1·min−1). However, the relative contribution of nitric oxide to the cutaneous vasodilator response (expressed as % of maximal cutaneous vascular conductance) was not different between groups ( P > 0.05). We conclude that cutaneous vasodilator responses to WBH are decreased in individuals with T2DM, but the contribution of nitric oxide to this smaller vasodilation is similar between T2DM and control individuals. This decrease in cutaneous vasodilation is likely an important contributor to impaired thermoregulation in T2DM.

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Mace, Thomas A., Casey Kilpatrick, Evan Zynda et Elizabeth Repasky. « Increased body temperature induces lymphocyte lipid raft aggregation (35.34) ». Journal of Immunology 182, n^o 1_Supplement (1 avril 2009) : 35.34. http://dx.doi.org/10.4049/jimmunol.182.supp.35.34.

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Abstract Previous recent data reveal that mild heating in vitro of CD4+ and CD8+ T cells (purified from murine splenocytes) at 39.5°C induces the aggregation of lipid rafts; approximately 70% of lymphocytes express aggregated lipid rafts compared to only 20% of cells maintained at 37oC as judged by the distribution of the lipid raft marker, fluorescently labeled GM1. Further, we found that the fluidity of the T cell plasma membrane, as measured by fluorescence anisotropy of TMA-DPH, increases when the temperature is raised from 37° to 39.5°C. Based on these in vitro results, we hypothesized that a physiologically relevant increase in body temperature results in an increase in lipid raft aggregation in T cells in situ. We administered whole body hyperthermia (WBH) to raise the temperature of mice to 39.5°C for 6 hours and immediately harvested and fixed cells from spleen and lymph nodes. Utilizing Imagestream flow cytometry, we observed a 3 fold increase in the number of CD8+ T cells with lipid raft aggregates isolated from WBH mice compared to T cells isolated from normothermic control mice. Lymphocytes from spleen and lymph nodes responded similarly to WBH. Overall, these findings may help to understand the role of physiological temperature shifts (e.g., during febrile episodes and inflammation) on costimulation and lymphocyte activation potential. Supported by NIH P01 CA94045 and RO1 CA71599

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Wilkinson, John Ben, Peter D. Beitsch, Douglas W. Arthur, Chirag Shah, Bruce George Haffty, David E. Wazer, Martin Keisch, Simona Flora Shaitelman, Maureen Lyden et Frank Vicini. « Evaluation of current consensus panel guidelines for APBI : A pooled analysis of William Beaumont Hospital and American Society of Breast Surgeons MammoSite registry trial data. » Journal of Clinical Oncology 30, n^o 27_suppl (20 septembre 2012) : 145. http://dx.doi.org/10.1200/jco.2012.30.27_suppl.145.

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145 Background: To determine whether the ASTRO Consensus Panel (CP) guidelines for accelerated partial breast irradiation (APBI) are associated with significantly different outcomes in a pooled analysis from William Beaumont Hospital (WBH) and the American Society of Breast Surgeons (ASBrS) MammoSite Registry Trial. Methods: 2,127 cases of early-stage breast cancer were treated using APBI (WBH: n=678; ASBrS: n=1,449). Three forms of APBI were used at WBH (interstitial, n=221; balloon-based, n=255; or 3D-CRT, n=206) while all Registry Trial patients received balloon-based brachytherapy. Patients with complete coding necessary for ASTRO CP assignment (n=1,813) were divided into suitable (n=661, 36.5%), cautionary (n=850, 46.9%), and unsuitable (n=302, 16.7%) categories. Tumor characteristics and clinical outcomes were analyzed according to CP group. Results: Median age was 65 years (32-94 years) and median tumor size was 10.0mm (0-45mm). The WBH cohort had more node-positive disease (6.9% vs. 2.6%, p<0.01) and cautionary patients (49.5% vs. 41.8%, p=0.06). Five-year rates of ipsilateral breast tumor recurrence (IBTR), regional nodal failure (RNF), and distant metastasis (DM) for the whole cohort were 2.8%, 0.6%, 1.6%, respectively. When analyzed by CP group, the rate of IBTR was not statistically higher for suitable (2.5%), cautionary (3.3%), or unsuitable (4.6%) patients (p=0.20). The non-significant increase in IBTR for grouped cautionary/unsuitable categories was due to increased elsewhere failures/new primaries (p=0.04), not true recurrences (1.1-1.2%, all groups, p=0.94). A higher rate of DM was observed within the cautionary and unsuitable groups (3.3-3.6% vs. 0.7% for suitable, p=0.01), although cause-specific survival was the same for all patient categories (98.0-98.6%, all groups, p=0.47). Conclusions: Excellent outcomes following breast conserving surgery and APBI were seen in our pooled analysis. The current ASTRO CP guidelines did not adequately differentiate patients at an increased risk of IBTR or tumor bed failure within the largest patient population of cases treated with APBI to date.

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Bibus, Erhard, Manfred Frechen, Michael Kösel et Wolfgang Rähle. « Das jungpleistozäne Lössprofil von Nussloch (SW-Wand) im Aufschluss der Heidelberger Zement AG ». E&G Quaternary Science Journal 56, n^o 4 (1 décembre 2007) : 227–55. http://dx.doi.org/10.3285/eg.56.4.01.

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Abstract. At the Nussloch section located south of Heidelberg, a more recently exposed new loess wall was pedologically investigated. The profiles were investigated multidisciplinarily including grain-size spectra, organic and carbonate content, magnetic susceptibility, as well as biomorphology and malacology and infrared optically stimulated luminescence (IRSL). The lower part of the Late Pleistocene includes the subdivided Eemian paleosol and the Wuermian loess about 18 m thick. A Bt horizon, a humic-rich horizon (“Humuszone”) and several tundra gleysols (“Nassböden”) of different intensity, with and without Bw horizons could be detected. Five brown soils (WB2 – WB6) are intercalated in the loess. The brown soils WB2, WB4 and WB5 correlate to interstadial periods, as evidenced by the mollusc spectra. Furthermore, WB1 correlates to one of the three Early Wuermian interstadials (“Mosbacher Humuszone”). Soil WB1 with an age estimate of about 75 ka BP represents the reduced Early Wuermian sequence. The most intensive brown soil (WB4) has the typical soil criteria of an arctic brown soil, which most likely correlates to the about 30 ka old Lohne Soil (“Lohner Boden”). The Late Wuermian loess covering the Lohne Soil is about 12 m thick and intercalated by at least ten tundra gleysols. The equivalent of the E2-Nassboden forms a tundra gley complex including also the weak brown soils WB5 and WB6. The youngest Upper Wuermian loess about 4.50 m thick covers the Eltville tephra and is designated to correlate to the E4/E5 complex. The paleopedological results are in excellent agreement with the results and interpretation by means of malacology and magnetic susceptibility enabling detailed stratigraphic and paleoclimatic reconstruction.

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Cyr, John St, T. Kelly et Linda M. Shecterle. « Whole Body Extracorporeal Low Flow Hyperthermia in a Canine Model ». Journal of ExtraCorporeal Technology 28, n^o 3 (septembre 1996) : 140–46. http://dx.doi.org/10.1051/ject/1996283140.

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Whole body hyperthermia (WBH) has not gained significant clinical acceptance, though extensive experimentation since the early 1980's has revealed its potential merits in the treatment of various cancers, and currently WBH is in clinical feasibility trials for Acquired Immune Deficiency Syndrome (AIDS). Using a new device and methodology, could canines serve as an appropriate test model for this device and methodology? Five dogs underwent one treatment each or the 42°C whole body hyperthermia using a low flow veno-venous approach. All animals were kept at the desired temperature for 90 minutes. There were no clinically significant acute or long term sequlae. Every animal was subjected to necropsy. Findings of this study showed that the canine was an adequate model to assess the initial safety of this new device.

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Hagedorn, W. Bryce, Jack R. Culbreth et Craig S. Cashwell. « Addiction Counseling Accreditation : CACREP’s Role in Solidifying the Counseling Profession ». Professional Counselor 2, n^o 2 (mai 2012) : 124–33. http://dx.doi.org/10.15241/wbh.2.2.124.

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Evans, Sharon S., Wan-Chao Wang, Mark D. Bain, Randy Burd, Julie R. Ostberg et Elizabeth A. Repasky. « Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules ». Blood 97, n^o 9 (1 mai 2001) : 2727–33. http://dx.doi.org/10.1182/blood.v97.9.2727.

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Abstract Fever is associated with increased survival during acute infection, although its mechanism of action is largely unknown. This study found evidence of an unexpectedly integrated mechanism by which fever-range temperatures stimulate lymphocyte homing to secondary lymphoid tissues by increasing L-selectin and α4β7 integrin–dependent adhesive interactions between circulating lymphocytes and specialized high endothelial venules (HEV). Exposure of splenic lymphocytes in vivo to fever-like whole-body hyperthermia (WBH; 39.8 ± 0.2°C for 6 hours) stimulated both L-selectin and α4β7 integrin–dependent adhesion of lymphocytes to HEV under shear conditions in lymph nodes and Peyer patches. The adhesiveness of HEV ligands for L-selectin and α4β7 integrin (ie, peripheral lymph node addressin and mucosal addressin cell adhesion molecule-1) also increased during WBH or febrile responses associated with lipopolysaccharide-induced or turpentine-induced inflammation. Similar increases in HEV adhesion occurred during hyperthermia treatment of lymph node and Peyer patch organ cultures in vitro, indicating that the local lymphoid tissue microenvironment is sufficient for the hyperthermia response. In contrast, WBH did not augment adhesion in squamous endothelium of nonlymphoid tissues. Analysis of homing of α4β7hi L-selectinlo murine TK1 cells and L-selectinhi α4β7 integrin-negative 300.19/L-selectin transfectant cells showed that fever-range temperatures caused a 3- to 4-fold increase in L-selectin and α4β7 integrin–dependent trafficking to secondary lymphoid tissues. Thus, enhanced lymphocyte delivery to HEV by febrile temperatures through bimodal regulation of lymphocyte and endothelial adhesion provides a novel mechanism to promote immune surveillance.

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Wang, Xiang-Yang, Julie R. Ostberg et Elizabeth A. Repasky. « Effect of Fever-Like Whole-Body Hyperthermia on Lymphocyte Spectrin Distribution, Protein Kinase C Activity, and Uropod Formation ». Journal of Immunology 162, n^o 6 (15 mars 1999) : 3378–87. http://dx.doi.org/10.4049/jimmunol.162.6.3378.

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Abstract Regional inflammation and systemic fever are hallmarks of host immune responses to pathogenic stimuli. Although the thermal element of fever is thought to enhance the activity of immune effector cells, it is unclear what the precise role of increased body temperatures is on the activation state and effector functions of lymphocytes. We report here that mild, fever-like whole body hyperthermia (WBH) treatment of mice results in a distinct increase in the numbers of tissue lymphocytes with polarized spectrin cytoskeletons and uropods, as visualized in situ. WBH also induces a coincident reorganization of protein kinase C (PKC) isozymes and increased PKC activity within T cells. These hyperthermia-induced cellular alterations are nearly identical with the previously described effects of Ag- and mitogen-induced activation on lymphocyte spectrin and PKC. Immunoprecipitation studies combined with dual staining and protein overlay assays confirmed the association of PKCβ and PKCθ with spectrin following its reorganization. The receptor for activated C kinase-1 was also found to associate with the spectrin-based cytoskeleton. Furthermore, all these molecules (spectrin, PKCβ, PKCθ, and receptor for activated C kinase-1) cotranslocate to the uropod. Enhanced intracellular spectrin phosphorylation upon WBH treatment of lymphocytes was also found and could be blocked by the PKC inhibitor bisindolylmaleimide I (GF109203X). These data suggest that the thermal element of fever, as mimicked by these studies, can modulate critical steps in the signal transduction pathways necessary for effective lymphocyte activation and function. Further work is needed to determine the cellular target(s) that transduces the signaling pathway(s) induced by hyperthermia.

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Cronau, L. H., D. L. Bourke et J. M. Bull. « CARDIOVASCULAR EFFECTS OF WHOLE BODY HYPERTHERMIA (WBH) (≥ 41.5 °C) DURING GENERAL ANESTHESIA ». Anesthesiology 63, Supplement (septembre 1985) : A1. http://dx.doi.org/10.1097/00000542-198509001-00001.

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Xu, Zhongming, Qinghua Wang, Yansong He, Zhifei Zhang, Shu Li et Mengran Li. « An Improved Algorithm for Noise Source Localization Based on Equivalent Source Method ». Shock and Vibration 2016 (2016) : 1–13. http://dx.doi.org/10.1155/2016/8302862.

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Near-field acoustical holography (NAH) based on the equivalent source method (ESM) is an efficient method applied for noise source identification. Asl2-norm-based regularization cannot produce a satisfactory solution of the ill-conditioned problem in high frequency, the conventional ESM is restricted to relatively low frequency, and the resolution of conventional ESM in middle to high frequency remains a limitation open to investigation. This article presents an algorithm known as improved functional equivalent source method (IFESM), designed to enhance the resolution of conventional ESM. This method is developed in the framework of wideband acoustical holography (WBH) combining with functional beamforming (FB). Through numerical simulations, it is proved that the proposed method can localize noise with higher resolution compared with WBH and conventional ESM, and the ghosts on noise source map can be suppressed effectively. The validity and the feasibility of the proposed method are manifested by experiments including single-source and coherent-source localization.

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McCullough, Patrick E., Diego Gómez De Barreda, Thomas V. Reed, Jialin Yu et F. Clint Waltz. « Sod Harvesting Intervals of Four Warm-Season Turfgrasses for Halosulfuron and Sulfentrazone ». Weed Technology 28, n^o 1 (mars 2014) : 47–57. http://dx.doi.org/10.1614/wt-d-13-00083.1.

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Sedges are problematic weeds that reduce quality of turfgrass sod, and herbicides may be needed for control prior to harvesting. The objective of this research was to evaluate application timing of halosulfuron and sulfentrazone on sod quality, tensile strength, and postharvest rooting of four warm-season turfgrasses. Bermudagrass injury from herbicides was minimal (< 10%), but injury to centipedegrass, St. Augustinegrass, and zoysiagrass was detected before harvesting and generally increased with sulfentrazone rate from 0.21 to 0.84 kg ai ha−1. Sod tensile strength was not reduced from the nontreated for bermudagrass and centipedegrass treated with herbicides, but tensile strength was reduced 15 and 22% following herbicide applications 1 wk before harvesting (WBH) St. Augustinegrass and zoysiagrass, respectively. Sulfentrazone at 0.84 kg ha−1reduced zoysiagrass tensile strength 20% from the nontreated, but other treatments did not reduce measurements. Turfgrass injury from halosulfuron was negligible on all species, and treatments did not affect sod tensile strength of the four species. Treatments did not affect root mass of any species at 4 wk after sod transplanting. Sod quality after transplanting was reduced from the nontreated on several dates for centipedegrass and St. Augustinegrass when treated with sulfentrazone 1 and 2 WBH, and zoysiagrass quality was reduced from treatments 4 WBH. Bermudagrass quality after transplanting was not reduced from the nontreated by any herbicides. Results suggest sod harvesting should be delayed 1, > 2, > 2, and ≥ 4 weeks after sulfentrazone applications at labeled rates for bermudagrass, centipedegrass, St. Augustinegrass, and zoysiagrass, respectively. Sod harvesting should be delayed 1, 2, ≥ 4, and 2 wk after halosulfuron treatments at 0.07 kg ai ha−1for bermudagrass, centipedegrass, St. Augustinegrass, and zoysiagrass, respectively.

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King, Yueh-Tsu, Chih-Sheng Lin, Jyh-Hung Lin et Wen-Chuan Lee. « Whole-body hyperthermia-induced thermotolerance is associated with the induction of Heat Shock Protein 70 in mice ». Journal of Experimental Biology 205, n^o 2 (15 janvier 2002) : 273–78. http://dx.doi.org/10.1242/jeb.205.2.273.

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SUMMARY Molecular mechanisms of whole-body thermotolerance (WBT) in mammals have not been investigated thoroughly. The purpose of this study was to assess the induction of the 70 kDa heat shock protein (HSP70) and antioxidant enzyme activity in animal WBT, which was induced by whole-body hyperthermia (WBH) in mice. As a preconditioning treatment, WBH was applied to mice to induce WBT. Synthesis of inducible HSP70 (HSP70i) and quantification of its increased level in liver were investigated by one- and two-dimensional polyacrylamide gel electrophoresis and immunoblotting. HSP70i synthesis in mice liver was induced by non-lethal WBH (41°C, 30 min). When compared to control animals, the level of liver HSP70i increased substantially (by 3.6-fold; P<0.0001). When exposed to 30 min of hyperthermia preconditioning, and after recovery for 48 h, the survival rate was 88.2 %, which was significantly higher than that of the control group (37.5 %; P<0.01). Moreover, the survival rate of animals subjected to preconditioning for 15 min was 72.2 %, which was also significantly higher than that of the control group (P<0.05). In contrast, the survival rate of animals subjected to preconditioning for 45 min was 63.5 %, which was not different from the control group. Nonetheless, the protection index of the group subjected to 15 min and 30 min of preconditioning was 1.93 and 2.37, respectively. Furthermore, to assess their contributions to WBT, the activities of antioxidant enzymes were also measured. After 48 h of recovery in preconditioned animals, hepatic antioxidant enzyme activities, including superoxide dismutase, catalase and glutathione peroxidase, had not changed significantly. To study the molecular mechanism of WBT, we successfully developed a mouse model and suggest that, rather than the activities of antioxidant enzymes, it is HSP70i that has a role to help animals survive during severe heat stress.

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Cękalska, Marta. « Początki „Przeglądu Historyczno- -Wojskowego” (1929–1939) ». Przegląd Historyczno-Wojskowy 20, n^o 4 (2019) : 11–43. http://dx.doi.org/10.32089/wbh.phw.2019.4(270).0001.

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The aim of the paper is to present the circumstances surrounding the establishment of the scientific journal „Military Historical Review” (PHW) in 1929. It was created on the initiative of the head of the Military Historical Bureau (WBH), Brigadier General Julian Stachiewicz, and focused on the military history until 1863. The supervision of the periodical was handed over to the head of the Independent Department of Previous Wars of the WBH, Major Otton Laskowski, and it featured publications of military, but above all civil researchers. The article presents the first concepts concerning the shape and functioning of the PHW, the response of the historical-military circles to the creation of the journal, as well as the verification of these ideas and declarations of cooperation in relation to the 10 volumes of the „Review” published in 1929–1938. The article also contains information on the editorial plans for 1939 and attempts to pinpoint the mission that the „Military Historical Review” was supposed to carry out in the interwar period.

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Elmehdi, Hussein M. « An evaluation of web-based homework (WBH) delivery systems : University of Sharjah Experience ». International Journal of Emerging Technologies in Learning (iJET) 8, n^o 4 (25 juillet 2013) : 57. http://dx.doi.org/10.3991/ijet.v8i4.2966.

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Alonso, K. « Cytokine levels in adult patients with solid tumours undergoing whole body hyperthermia (WBH) ». International Journal of Hyperthermia 13, n^o 5 (janvier 1997) : 559–60. http://dx.doi.org/10.3109/02656739709023554.

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Gijsen, Matthias, Dirk Vlasselaers, Isabel Spriet et Karel Allegaert. « Pharmacokinetics of Antibiotics in Pediatric Intensive Care : Fostering Variability to Attain Precision Medicine ». Antibiotics 10, n^o 10 (28 septembre 2021) : 1182. http://dx.doi.org/10.3390/antibiotics10101182.

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Children show important developmental and maturational changes, which may contribute greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK alterations are further enhanced by disease-related, non-maturational factors. Specific to the intensive care setting, such factors include critical illness, inflammatory status, augmented renal clearance (ARC), as well as therapeutic interventions (e.g., extracorporeal organ support systems or whole-body hypothermia [WBH]). This narrative review illustrates the relevance of both maturational and non-maturational changes in absorption, distribution, metabolism, and excretion (ADME) applied to antibiotics. It hereby provides a focused assessment of the available literature on the impact of critical illness—in general, and in specific subpopulations (ARC, extracorporeal organ support systems, WBH)—on PK and potential underexposure in children and neonates. Overall, literature discussing antibiotic PK alterations in pediatric intensive care is scarce. Most studies describe antibiotics commonly monitored in clinical practice such as vancomycin and aminoglycosides. Because of the large PK variability, therapeutic drug monitoring, further extended to other antibiotics, and integration of model-informed precision dosing in clinical practice are suggested to optimise antibiotic dose and exposure in each newborn, infant, or child during intensive care.

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Niu, Xiaojing, Xiaomei Zhao, Dongfan Xie et Jun Bi. « Modeling and Control of Network Macroscopic Fundamental Diagram during Holidays : A Case Study of Qingming Festival in Tianjin ». Applied Sciences 13, n^o 14 (20 juillet 2023) : 8399. http://dx.doi.org/10.3390/app13148399.

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In this paper, the macroscopic traffic states and network traffic dynamics during the Qingming Festival holiday are explored with the Macroscopic Fundament Diagram (MFD), including the weekday before the holiday (WBH), the day of Qingming Festival (DQF), and the ordinary weekday (OW). The network is heterogeneous on the densities’ distribution, and the congested areas are different in location and size. Normalized Cut (Ncut) algorithm is used to partition the heterogeneous network into multiple homogeneous subregions. The MFD of each subregion is distributed within the critical density on the WBH, and the high-density region moves from the city center to the periphery. On the DQF, high-density areas are on the central and west of the urban network. The congested branch appears on the MFD of the subregion. Then, two calibrated dynamic models, are applied to analyze the network evolution based on the partitioning results. On the basis of the calibrated model, several control strategies are proposed to relieve regional congestion on holidays. According to the simulation results, congestion on the DQF can be alleviated by controlling the external inflow ratio of subregion 2 or limiting the amount of traffic entering subregion 2 from the outside.

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Ganta, Chanran K., Frank Blecha, Roman R. Ganta, Bryan G. Helwig, Sujatha Parimi, Ning Lu, Richard J. Fels, Timothy I. Musch et Michael J. Kenney. « Hyperthermia-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system ». Physiological Genomics 19, n^o 2 (4 octobre 2004) : 175–83. http://dx.doi.org/10.1152/physiolgenomics.00109.2004.

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Whole body hyperthermia (WBH) has been used in experimental settings as an adjunct to radiochemotherapy for the treatment of various malignant diseases. The therapeutic effect of WBH has been hypothesized to involve activation of the immune system, although the effect of hyperthermia-induced activation of sympathetic nerve discharge (SND) on splenic immune function is not known. We tested the hypothesis that heating-induced splenic sympathoexcitation would alter splenic cytokine gene expression as determined using gene array and real-time RT-PCR analyses. Experiments were performed in splenic-intact and splenic-denervated anesthetized Sprague-Dawley rats ( n=32). Splenic SND was increased during heating (internal temperature increased from 38° to 41°C) in splenic-intact rats but remained unchanged in nonheated splenic-intact rats. Splenic interleukin-1β (IL-1β), interleukin-6 (IL-6), and growth-regulated oncogene 1 (GRO 1) mRNA expression was higher in heated than in nonheated splenic-intact rats. Splenic IL-1β, IL-6, and GRO 1 mRNA expression was reduced in heated splenic-denervated compared with heated splenic-intact rats, but did not differ between heated splenic-denervated and nonheated splenic-intact rats. These results support the hypothesis that hyperthermia-induced activation of splenic SND enhances splenic cytokine gene expression.

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Shi, Tongyang, J. S. Bolton et Frank Eberhardt. « A hybrid compressive sensing approach to noise source visualization : Application to a diesel engine ». Journal of the Acoustical Society of America 153, n^o 3_supplement (1 mars 2023) : A55. http://dx.doi.org/10.1121/10.0018144.

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To identify sound source locations by using Fourier-based Near-field Acoustical Holography (NAH), a large number of microphone measurements is generally required to span the source region and ensure a sufficiently high spatial sampling rate. As a result, such measurements are costly, a fact which has discouraged the industrial application of NAH to identify sound source locations. However, recently, compressive sensing approaches have made it feasible to identify concentrated sound sources with a limited number of microphone measurements. In the present work, sound radiation from the front face of a diesel engine was measured by using one set of measurements from a 35-channel combo-array. The locations of significant noise sources were then identified by using three compressive sensing algorithms: Wideband Acoustical Holography (WBH), l1-norm minimization, and a hybrid approach which combined WBH and l1-norm minimization. The latter approach takes advantage of the l1’ norm’s ability to locate spatially distinct sources, and WBH’s ability to suppress “ghost” sources. It was found that the hybrid algorithm can localize and visualize the major noise sources over a broad range of frequencies, even though using a relatively small number of microphones. Finally, comments are made regarding sound field reconstruction differences between the algorithms.

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Liangsong, Chen, He Yansong, Niu Xiyuan, Bao Jian et Li Wei. « An alternating iterative algorithm for sound source identification based on equivalent source method ». Noise Control Engineering Journal 68, n^o 1 (20 janvier 2020) : 59–71. http://dx.doi.org/10.3397/1/37685.

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Near-field acoustical holography (NAH) based on equivalent source method (ESM) is an efficient technique for sound source identification. Conventional ESM with Tikhonov regularization (TRESM), ESM based on CVX MATLAB toolbox (CVX) and wideband acoustic holography (WBH) are commonly used methods for calculating equivalent source strengths. However, all of them have their respective limitations. To address some of these, an alternating iterative algorithm for sound source identification based on equivalent source method (AIESM) is proposed in this article, which is a combination of alternating direction method and a non-monotone line search technique. The method makes use of sparse regularization under the principle of compressive sensing (CS) to calculate equivalent source strengths. Moreover, inspired by the idea of functional beamforming (FB), AIESM with order n can yield an improved dynamic range when detecting the source location. Numerical simulations are carried out at different frequencies, and the results suggest that the computational efficiency of the proposed method is close to that of TRESM. In addition, AIESM has a better reconstruction accuracy than TRESM and WBH in a relatively wide frequency range. Compared with ESM based on CVX, AIESM is slightly better in reconstruction accuracy and has a higher computational efficiency. Meanwhile, AIESM with order n can provide more accurate source position and better resolution. The validity and practicality of the proposed method are further supported by experimental results.

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Wang, Junli, Rima Solianik, Nerijus Eimantas, Neringa Baranauskiene et Marius Brazaitis. « Age-Related Difference in Cognitive Performance under Severe Whole-Body Hyperthermia Parallels Cortisol and Physical Strain Responses ». Medicina 59, n^o 9 (14 septembre 2023) : 1665. http://dx.doi.org/10.3390/medicina59091665.

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Background and Objectives: To date, understanding age-related changes in cognitive processes during heat exposure still needs to be better-understood. Thus, the main aim of the current study was to evaluate the effects of whole-body hyperthermia (WBH), i.e., a ≈ 2.5 °C increase in rectal temperature (Tre) from overnight-fast baseline value, on cognitive functioning in old and young men and to explore factors, such as stress and thermophysiological strain, that could influence such changes. Materials and Methods: Ten young (19–21 years of age) and nine old (61–80 years of age) healthy men underwent an experimental trial with passive lower-body heating in hot water immersion (HWI) at 43 °C (HWI–43 °C) until Tre reached 39 °C in old adults and 39.5 °C in young adults. Cognitive performance and cortisol concentration were assessed before and after HWI, and the physiological strain index (PSI) was assessed during HWI–43 °C. Results: PSI was lower and cortisol concentration was greater after HWI–43 °C in the old group compared with the young group (p < 0.05). Surprisingly, hyperthermia improved cognitive flexibility only in old adults, whereas short-term and visual recognition memories were maintained in both age groups. Conclusions: A ≈ 2.5 °C increase in rectal temperature can improve executive function in old adults, and this increase parallels the increased cortisol concentration and the lower thermophysiological strain under severe WBH conditions.

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Richel, O., P. J. Zum Vörde Sive Vörding, R. Rietbroek, J. Vander Velden, J. D. P. Van Dijk, M. S. Schilthuis et A. M. Westermann. « Phase II study of carboplatin and whole body hyperthermia (WBH) in recurrent and metastatic cervical cancer ». Gynecologic Oncology 95, n^o 3 (décembre 2004) : 680–85. http://dx.doi.org/10.1016/j.ygyno.2004.08.023.

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Atmaca, Akin, Salah-Eddin Al-Batran, Antje Neumann, Yvonne Kolassa, Dirk Jäger, Alexander Knuth et Elke Jäger. « Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer — A phase II study ». Gynecologic Oncology 112, n^o 2 (février 2009) : 384–88. http://dx.doi.org/10.1016/j.ygyno.2008.11.001.

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