Thèses sur le sujet « Virulence determinant »
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Aish, Joanne Louise. « Environmental regulation of virulence determinant expression in Staphylococcus aureus ». Thesis, University of Sheffield, 2003. http://etheses.whiterose.ac.uk/3030/.
Texte intégralHorsburgh, Samantha. « Identification of novel regulators of virulence determinant production in Staphylcoccus aureus ». Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274960.
Texte intégralDade, Jessica E. « HcZrt2, a Zinc Transporter and Nutritional Virulence Determinant in Histoplasma Capsulatum ». University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470753451.
Texte intégralApagyi, Katinka. « Characterization of a novel virulence determinant in Erwinia carotovora subspecies atroseptica SCRI1043 ». Thesis, University of Cambridge, 2012. https://www.repository.cam.ac.uk/handle/1810/265545.
Texte intégralMateo, Montalcini Solange A. « AGC kinase Sta1 is a virulence determinant in the rice blast fungus ». Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531838.
Texte intégralStapleton, Melanie. « Studies with SlyA, a transcription regulator and virulence determinant of Salmonella typhimurium ». Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274957.
Texte intégralMarroquin, Stephanie Michelle. « A Novel Abi-domain Protein Controls Virulence Determinant Production in Staphylococcus aureus ». Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6725.
Texte intégralPrice, Maeve. « SSWl encodes a glycolipid-anchored surface protein and is a virulence determinant in M oryzae ». Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526103.
Texte intégralSodeinde, Olanrewaju A. « Identification and Characterization of the Virulence Determinant of the 9.5 Kilobase Plasmid of Yersinia Pestis : a Thesis ». eScholarship@UMMS, 1990. http://escholarship.umassmed.edu/gsbs_diss/310.
Texte intégralKleij, Lena. « Identification and validation of the virulence determinants of circulating equine influenza viruses ». Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL136.
Texte intégralInfluenza viruses are enveloped, their genome being segmented into 8 negative RNA segments. They are classified in the Orthomyxoviridae family. They are the etiological agents of the flu, a respiratory disease that affects many mammalian and avian species. Equine influenza is caused by the H3N8 and H7N7 subtypes of the type A influenza virus, the latter being extinct since the 1970s. Despite the existence of a vaccine, France has experienced several H3N8 epidemics since the 2000s. To reduce the significant economic impact of these epidemics for the equine industry, it is necessary to establish rapid, robust, and on-terrain applicable diagnostic tests to limit the circulation of the virus as much as possible and identify its virulence determinants as well as characterize antigenic drift.We studied the potential of the so-called “long read” sequencing technique developed by Oxford Nanopore Technologies. We carried out a characterization of the complete genome of two equine H3N8 viruses that circulated in France in 2009 and 2018 (A/equine/Paris/1/2018 and A/equine/Beuvron-en-Auge/2/2009, two viruses of clade 1 Florida) as well as the two strains of the vaccine commonly used in France.Our results demonstrated the reliability of this sequencing technique using amplicons of the eight genomic segments of the four viruses analyzed as well as the ability to produce reliable readings from direct sequencing of viral RNA (results presented in the first part). Analysis of the amino acid sequence of hemagglutinin HA of circulating strains demonstrated a very slight antigenic drift compared to vaccine strains with specific substitutions such as T161I in A/equine/Paris/1/2018 and N188T in the post-2015 strains, two substitutions located in the antigenic site B. The antigenic site E also shows modifications in the post-2018 strains, with the N63D substitution.Genomic segment 2 encodes one of the three subunits of the viral RNA polymerase, PB1, as well as an accessory protein, PB1-F2, of an alternative reading frame. PB1-F2 is recognized as a virulence determinant. While the A/equine/Paris/1/2018 strain encodes a variant 90 amino acids long, many strains, including A/equine/Beuvron-en-Auge/2/2009, encode a variant only 81 residues. Biological and biochemical tests were carried out to characterize the properties of each of these two forms of PB1-F2. In an assay where the long form of PB1-F2 is expressed in eukaryotic cells without other viral constituents, it abolishes the membrane potential of the cellular mitochondria. Placed in the presence of synthetic vesicles mimicking the mitochondrial outer membrane, the long form of PB1-F2 permeabilizes them more effectively than the short form. Amino acid sequence analyzes of the viral proteins (mainly HA and PB1-F2) are presented in a second part.In order to validate the impact of PB1-F2 on virulence in an infectious context, we sought to establish a reverse genetics system for the A/equine/Paris/1/2018 virus (third part). To do this, the 8 genomic segments were cloned into the pRF483 plasmid to ensure the synthesis of genomic RNA strands and the expression of viral proteins. The sequence of the inserts of each of the plasmids was validated. To validate the functioning of the replicative complex encoded by 4 of the 8 viral segments cloned in pRF483 (PA, PB1, PB2 and NP), these plasmids were transfected with a plasmid coding for the NA genomic segment in which its reading frame was substituted. by a reporter gene, luciferase. Under these experimental conditions, activity of the RNA-polymerase complex was detected. These tests will be extended for the production of recombinant viruses by transfection of the 8 constructed plasmids
Borgia, Sergio M. « Characterization of a virulence determinant from group A Streptococcus, identification of a novel chromosomal region responsible for streptolysin S production in Streptococcus pyogenes ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0003/MQ45472.pdf.
Texte intégralHarper, Marina. « Virulence determinants of Pasteurella multocida ». Monash University, Dept. of Microbiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9341.
Texte intégralAtkins, Timothy Philip. « Virulence determinants of Burkholderia pseudomallei ». Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325608.
Texte intégralKapoor, Sanjay. « Molecular determinants of rotavirus virulence ». Thesis, University of Warwick, 1995. http://wrap.warwick.ac.uk/4250/.
Texte intégralTamošiūnaitė, Aistė [Verfasser]. « Cowpox virus virulence determinants / Aistė Tamošiūnaitė ». Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1191180964/34.
Texte intégralJanowicz, Anna Agata. « Molecular determinants of bluetongue virus virulence ». Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6959/.
Texte intégralConnolly, John. « Analysis of Staphylococcus aureus virulence determinants ». Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/12109/.
Texte intégralRudd, Matthew Francis, et mikewood@deakin edu au. « Virulence determinants of infectious bursal disease virus ». Deakin University. School of Biological and Chemical Sciences, 2003. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050825.103742.
Texte intégralSkinner, Anita Claire. « Molecular determinants of virulence in Leishmania mexicana ». Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337830.
Texte intégralLewis, David Arthur. « Potential virulence determinants in Haemophilus ducreyi infection ». Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341930.
Texte intégralBoonchai, S. « The virulence determinants of uropathogenic Escherichia coli ». Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354421.
Texte intégralHarvey, Philippa Caroline. « Determinants of survival and virulence of Campylobacter ». Thesis, Open University, 2000. http://oro.open.ac.uk/58052/.
Texte intégralSteggles, James Robert. « Virulence determinants and pathogenesis of Bacillus thuringiensis ». Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614837.
Texte intégralMottola, Carla. « Virulence characterization and antimicrobial resistance of major bacterial genera from diabetic foot infections ». Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/14119.
Texte intégralDiabetes mellitus is a major chronic disease that continues to increase significantly. One of the most important and costly complications of diabetes is the development of foot ulcers, colonized by pathogenic and antimicrobial resistant bacteria, which may be responsible for impairing its successful treatment. Diabetic foot ulcer (DFU) bacterial communities can be organized in polymicrobial biofilms, which may be responsible for its chronicity. The ability of these communities to produce biofilm was evaluated and was higher when compared to biofilm formation by individual species. Staphylococcus aureus is one of the most prevalent species in diabetic foot infections (DFI). Staphylococci isolated from DFU in patients from the Lisbon area were identified, genotyped and screened for virulence and antimicrobial resistance traits. The isolates showed high genomic diversity, were resistant to important clinically antibiotics and expressed relevant virulence determinants. As biofilm formation is one of the most important virulence traits of S. aureus, the antimicrobial susceptibility patterns of biofilm-producing S. aureus strains were also analysed. The minimum biofilm inhibitory and eradication concentrations were determined for ten antimicrobial compounds. Staphylococci biofilms were resistant to antibiotic concentrations ten to thousand times higher than those effective for planktonic cells. Furthermore, the enterococci frequently isolated from DFI, were also identified and characterized, showing high antimicrobial resistance and important virulence traits. Since DFI are often caused by resistant bacteria, it is necessary to find alternatives to antibiotic therapy, such as phage therapy. The inhibitory potential of five bacteriophages, previously characterized, was evaluated against established biofilms formed by S. aureus, P. aeruginosa and A. baumannii. A significant cell reduction after phage exposure was observed, mainly after multiple treatments. DFI are very complex and studies on this topic are scarce. It is necessary to intensify research in order to develop more adequate therapeutic protocols for this type of infection.
RESUMO - Caracterização da virulência e resistência a antimicrobianos dos principais géneros bacterianos envolvidos em infeções de pé diabético - Diabetes mellitus é uma doença crónica com grande impacto em saúde pública e cuja incidência continua a aumentar significativamente em todo o mundo, atingindo atualmente mais de 400 milhões de pessoas. Uma das complicações mais importantes da diabetes e associada a gastos económicos significativos são as úlceras de pé diabético. Uma vez que a camada protetora de pele é danificada, os tecidos profundos ficam expostos à infeção bacteriana, a qual pode evoluir rapidamente. As infeções das úlceras de pé diabético são a causa mais comum de internamento hospitalar de pacientes diabéticos e uma importante causa de morbilidade, levando frequentemente à amputação dos membros inferiores. Estas infeções podem ser promovidas por bactérias potencialmente patogénicas e resistentes aos compostos antimicrobianos, prejudicando assim o sucesso do tratamento. As comunidades bacterianas presentes nas úlceras podem estar organizadas em biofilmes polimicrobianos, que contribuem para que as infeções se tornem crónicas e muito difíceis de resolver. Foi avaliada a capacidade de produção de biofilme por comunidades polimicrobianas de isolados bacterianos de pé diabético, utilizando um ensaio de microtitulação em placa com “Alamar Blue” (AB) e uma técnica de Hibridação In Situ Fluorescente Múltipla (MFISH). Esta avaliação foi realizada em três períodos de incubação distintos (24, 48 e 72 horas), depois da determinação da capacidade de formação de biofilme por 95 isolados de úlceras de pé diabético pertencentes a vários géneros bacterianos (Staphylococcus, Corynebacterium, Enterococcus, Pseudomonas e Acinetobacter). Todos os isolados apresentaram a capacidade de produzir biofilme às 24 horas, sendo que a quantidade de biofilme produzido aumentou com o tempo de incubação. Pseudomonas apresentou a capacidade mais elevada de produção de biofilme, seguida de Corynebacterium, Acinetobacter, Staphylococcus e por fim, Enterococcus. Foram encontradas diferenças estatisticamente significativas na capacidade de formação de biofilme entre os três períodos de incubação. As comunidades polimicrobianas produziram mais biofilme do que as espécies individualmente. As comunidades formadas por Pseudomonas + Enterococcus, Staphylococcus + Acinetobacter e Corynebacterium + Staphylococcus formaram mais biofilme do que as comunidades formadas por Enterococcus + Staphylococcus e por Enterococcus + Corynebacterium. O comportamento biológico das diferentes espécies bacterianas nos biofilmes polimicrobianos tem implicações clínicas muito importantes para o sucesso do tratamento deste tipo de infeções. A sinergia entre as bactérias presentes em biofilmes multiespécies foi descrita previamente, sendo que este trabalho representa o primeiro estudo sobre a evolução temporal da formação de biofilme por parte de comunidades polimicrobianas isoladas de úlceras de pé diabético, incluindo várias espécies. [...]
Centro de Investigação Interdisciplinar em Sanidade Animal” (CIISA) of Faculty of Veterinary Medicine, University of Lisbon, Portugal
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Moore, Jane. « Putative bacteroides fragilis virulence determinants ; analysis and comparison ». Thesis, Queen's University Belfast, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486575.
Texte intégralLam, T. H. Jason, et 林梓軒. « The study of virulence determinants of mycobacterium tuberculosis ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47849757.
Texte intégralpublished_or_final_version
Microbiology
Doctoral
Doctor of Philosophy
Yasir, Muhammad. « Regulation of virulence determinants in enteroaggregative Escherichia Coli ». Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7251/.
Texte intégralPemberton, Clare Louise. « Virulence determinants and their regulation in Erwinia carotovora ». Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614742.
Texte intégralHapeshi, Alexia. « Chromosomal and plasmid determinants of Rhodococcus equi virulence ». Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17281.
Texte intégralLi, Alice Hoy Lam. « Identification of virulence determinants of Mycobacterium tuberculosis via genetic comparisons of a virulent and an attenuated strain of Mycobacterium tuberculosis ». Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/596.
Texte intégralAbdullah, Abdallah Ibansharred. « Virulence determinants of aeromonads and other gram-negative bacteria ». Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275038.
Texte intégralDziva, Francis. « Virulence determinants of pasteurella multiocida with bovine haemorrhagic septicaemia ». Thesis, Royal Veterinary College (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265334.
Texte intégralTurner, Lauren. « Identification of Virulence Determinants for Streptococcus sanguinis Infective Endocarditis ». VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1560.
Texte intégralTurner, Lauren Senty. « Identification of virulence determinants for streptococcus sanguinis infective endocarditis / ». Online version not available until 8/4/2013, 2008. http://hdl.handle.net/10156/2243.
Texte intégralAgena, Mahmoud B. « Neonatal exposure to pathogens : determining key virulence factors ». Thesis, Nottingham Trent University, 2017. http://irep.ntu.ac.uk/id/eprint/32859/.
Texte intégralFletcher, Jonathan Nigel. « Plasmid-encoded virulence determinants of an enteropathogenic (0111) Escherichia coli ». Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316601.
Texte intégralFarrant, Jayne Lisa. « Molecular characterisation of the virulence determinants of enteropathogenic Escherichia coli ». Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385084.
Texte intégralHaycocks, James Richard John. « Regulating expression of virulence determinants in enterotoxigenic Escherichia coli H10407 ». Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5650/.
Texte intégralIreri, Ricki Gatumu. « Studies on some determinants of virulence in Alcelaphine herpesvirus 1 ». Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/29817.
Texte intégralMacFarlane, Ryan Cousteau. « Identification of virulence determinants in the protozoan parasite entamoeba histolytica / ». May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Texte intégralHyatt, Doreene Rose. « The hemolysins produced by Serpulina hyodysenteriae as putative virulence determinants ». Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/187349.
Texte intégralKanvil, Sadia. « Pea aphid virulence factors determining compatibility with Medicago truncatula ». Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39392.
Texte intégralKamran, Mohammed Farakh. « The identification and isolation of putative virulence determinants of Candida glabrata ». Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409177.
Texte intégralQUILICI, MARIE-LAURE. « Les determinants plasmidiques impliques dans la virulence et l'immunogenicite des yersinia ». Paris 7, 1992. http://www.theses.fr/1992PA077162.
Texte intégralBrown, Meredith A. « Genetic determinants of virulence in emerging viruses of natural felid populations ». Diss., Connect to online resource - MSU authorized users, 2008.
Trouver le texte intégralTitle from PDF t.p. (viewed on April 1, 2009) Includes bibliographical references (p. 101-117). Also issued in print.
Feavers, L. M. « The biological properties and genetic determinants of virulence factors of Escherichia coli ». Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370615.
Texte intégralWilson, Lynn Margaret. « Physiological studies on swarming and production of virulence determinants in Clostridium septicum ». Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627209.
Texte intégralWallace, Nathan Christopher. « Metabolic and Physiological Determinants in Listeria monocytogenes Anaerobic Virulence Regulation ». University of Dayton / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1543424768026244.
Texte intégralPerry, Kyle James. « Differential fluorescence-based genetic screens to identify novel Listeria monocytogenes virulence determinants ». Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226063.
Texte intégralHariri, S. H. « Identification of the virulence determinants of the neonatal meningitic bacterium Cronobacter sakazakii ». Thesis, Nottingham Trent University, 2015. http://irep.ntu.ac.uk/id/eprint/27928/.
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