Bibliographies thématiques / Via Lata

Littérature scientifique sur le sujet « Via Lata »

Auteur : Grafiati
Publié le 10 mars 2023

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Articles de revues sur le sujet "Via Lata"

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Shen, Le, et Jerrold R. Turner. « Actin Depolymerization Disrupts Tight Junctions via Caveolae-mediated Endocytosis ». Molecular Biology of the Cell 16, no 9 (septembre 2005) : 3919–36. http://dx.doi.org/10.1091/mbc.e04-12-1089.

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The tight junction (TJ) determines epithelial barrier function. Actin depolymerization disrupts TJ structure and barrier function, but the mechanisms of this effect remain poorly understood. The goal of this study was to define these mechanisms. Madin-Darby canine kidney (MDCK) cells expressing enhanced green fluorescent protein-, enhanced yellow fluorescent protein-, or monomeric red fluorescent protein 1-fusion proteins of β-actin, occludin, claudin-1, ZO-1, clathrin light chain A1, and caveolin-1 were imaged by time-lapse multidimensional fluorescence microscopy with simultaneous measurement of transepithelial electrical resistance (TER). Actin depolymerization was induced with latrunculin A (LatA). Within minutes of LatA addition TER began to fall. This coincided with occludin redistribution and internalization. In contrast, ZO-1 and claudin-1 redistribution occurred well after maximal TER loss. Occludin internalization and TER loss, but not actin depolymerization, were blocked at 14°C, suggesting that membrane traffic is required for both events. Inhibition of membrane traffic with 0.4 M sucrose also blocked occludin internalization and TER loss. Internalized occludin colocalized with caveolin-1 and dynamin II, but not with clathrin, and internalization was blocked by dominant negative dynamin II (K44A), but not by Eps15Δ95-295 expression. Inhibition of caveolae-mediated endocytosis by cholesterol extraction prevented both LatA-induced TER loss and occludin internalization. Thus, LatA-induced actin depolymerization causes TJ structural and functional disruption by mechanisms that include caveolae-mediated endocytosis of TJ components.
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Krause, Gerd, et Katrin Manuela Hinz. « Molecular Mechanisms of Thyroid Hormone Transport by l-Type Amino Acid Transporter ». Experimental and Clinical Endocrinology & ; Diabetes 128, no 06/07 (18 novembre 2019) : 379–82. http://dx.doi.org/10.1055/a-1032-8369.

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AbstractThyroid hormones (TH) pass through the plasma membrane into the target cells via transporter proteins. Thyroid hormone transporters that have been identified until now belong to two different solute carrier (SLC) subfamilies i) the major facilitator superfamily (MFS) and ii) the amino acid polyamine-organocation (APC) superfamily. Both are comprised by 12 transmembrane helices, however with different structural topology. The TH transporter MCT8, MCT10 and OATP1C1 are members of the MSF. The l-type amino acid transporters (LATs) are transporting neutral amino acids across the membrane. Two LAT subtypes, LAT1 and LAT2 are members of the APC superfamily, need the escort protein 4F2hc and facilitate uptake but no efflux of TH-subtypes. Homology models of LAT2 that are based on crystal structures of APC transporters guided mutagenesis, revealed molecular structure-function determinants for recognition and transition for import and export of TH-subtypes. The recently solved cryo-EM structure of LAT1 confirmed the structural input. Two other LAT subtypes, LAT3 and LAT4 are members of the MFS. From previous observed negative effect of LAT3 and LAT4 on 3,3’-T2 uptake by LAT1 and LAT2 it was indirectly concluded that LAT3 might export 3,3’-T2. There are still open questions that need to be addressed in order to fully understand the molecular recognition pattern and traversing mechanism of import and export of particular TH-subtypes by LAT1 and LAT2. Moreover, clarification is needed whether LAT3 and LAT4 are exporting TH. Recent new data could not verify the initial hypothesis of TH export by LAT3. Therefore, further investigations are necessary to explain the negative effect of LAT3 on the TH import by LAT2.
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Habel, Dorothy Metzger. « Bernini's d'Aste Family Tombs in S. Maria in Via Lata, Rome : A Reconstruction ». Art Bulletin 79, no 2 (juin 1997) : 291–300. http://dx.doi.org/10.1080/00043079.1997.10786736.

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Muth-seng, C., L. L. Gras, A. Roux et S. Laporte. « Modelling of fascia lata rupture during tensile tests via the discrete element method ». Computer Methods in Biomechanics and Biomedical Engineering 20, sup1 (27 octobre 2017) : S147—S148. http://dx.doi.org/10.1080/10255842.2017.1382904.

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Habel, Dorothy Metzger. « Bernini's d'Aste Family Tombs in S. Maria in Via Lata, Rome : A Reconstruction ». Art Bulletin 79, no 2 (juin 1997) : 291. http://dx.doi.org/10.2307/3046247.

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Gołaczyński, Jacek. « Informatization of Civil Proceedings in Poland. Conclusions de lege lata ». Acta Universitatis Sapientiae, Legal Studies 10, no 2 (15 décembre 2021) : 191–214. http://dx.doi.org/10.47745/ausleg.2021.10.2.03.

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The informatization of civil proceedings is regulated in Poland by the use of several instruments pertaining to various aspects of civil procedure. The author presents the most relevant instruments and their major provisions in the context of what may be called ‘normal’ circumstances and also as they were amended to suit the needs of the judiciary during the COVID-19 pandemic. Submission of pleadings via the dedicated ICT (information and communication technology) system of the courts is presented, as is the electronic delivery service meant to facilitate the service of procedure and the communication of procedural documents in Poland (especially in the future). The rules applicable to open hearings and recording of hearings, as well as their transmission, are presented. The relatively novel rules on the taking of electronic evidence and on rendering an ‘e-judgment’ are also referred to.
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Ferreira, Manoel Luiz, Alberto Schanaider, Paulo César Silva, Antônio Victor de Abreu, Andrei Ferreira Nicolau Costa, Jalene Meira Braga, Raul Rousso Filho et Lara de Paula M. Pereira. « Estudo da técnica da sindesmoplastia extra-articular com fascia lata autógena : modelo em cães ». Revista do Colégio Brasileiro de Cirurgiões 36, no 2 (avril 2009) : 161–66. http://dx.doi.org/10.1590/s0100-69912009000200014.

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OBJETIVO: Avaliar a eficácia da técnica extra-capsular para o tratamento de ruptura do ligamento cruzado anterior em cães. MÉTODOS: Foi realizada a reparação cirúrgica extra-articular, sem artrotomia do ligamento cruzado anterior, com a utilização da fáscia lata autógena para estabilização da articulação do joelho em seis animais que apresentaram claudicação grave e movimento de gaveta positivo. RESULTADOS: A técnica cirúrgica extra-articular foi eficaz com boa estabilização articular e evolução satisfatória. CONCLUSÃO: A via extra capsular com uso da fáscia lata para correção da ruptura do ligamento cruzado anterior mostrou-se útil haja vista tratar-se de um procedimento simples e de rápida execução, causando o mínimo dano tecidual e recuperação pós-operatória eficiente.
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Bonkowski, Janusz A., Robin D. Gibson et Leslie Snape. « Foramen magnum meningioma : transoral resection with a bone baffle to prevent CSF leakage ». Journal of Neurosurgery 72, no 3 (mars 1990) : 493–96. http://dx.doi.org/10.3171/jns.1990.72.3.0493.

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✓ A case of meningioma situated at the anterior rim of the foramen magnum with successful removal via a transoral approach is reported. A new technique of preventing cerebrospinal fluid leakage is described utilizing fascia lata and a bone baffle without any attempt to close the dura, either by primary suture or tissue sealants.
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Wójcicka, Ewa. « Oddanie pisma w placówce operatora pocztowego – uwagi de lege lata i de lege ferenda ». Studia Iuridica 72 (17 avril 2018) : 415–29. http://dx.doi.org/10.5604/01.3001.0011.7642.

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The aim of this article is to discuss the problems of submitting process letters to courts and public administration bodies via a postal operator as well as to indicate essential problems caused by unjustified differentiation of standards concerning the compliance with time-limits when the subject has limited or excluded opportunity to lodge a pleading a letter in person. Only in criminal proceedings and proceedings in cases of offences the participants have full freedom to choose a postal operator and to benefit from the presumption of lodging of a submitting a letter in the date of sending. In administrative proceedings, administrative court proceedings and tax proceedings, to be sure that legal deadline will be met, one should submit a letter to a court or a public administration body via a postal operator providing universal postal services. The article drew attention to a lack of consistency and consequence of the legislator relating to the regulation of submitting letters depending on the nature of proceedings and place of residence.
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Fliss, Dan M., Ziv Gil, Sergey Spektor, Leonor Leider-Trejo, Avraham Abergel, Avi Khafif, Aharon Amir, Eyal Gur et Jacob T. Cohen. « Skull base reconstruction after anterior subcranial tumor resection ». Neurosurgical Focus 12, no 5 (mai 2002) : 1–7. http://dx.doi.org/10.3171/foc.2002.12.5.11.

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Object The goal of this study was to demonstrate the efficacy of a simple and reliable technique for anterior skull base and craniofacial reconstruction in patients who have undergone excision of tumors via the subcranial approach. Methods There were 63 patients who had undergone 71 anterior skull base resections of tumors via the aforementioned approach. Twenty-nine cases (41%) involved malignant tumors and 42 (59%) involved benign tumors. Reconstruction of the anterior skull base was performed by a single team who used double-layer fascial graft. Limited dural defects were reconstructed using the temporalis fascia, whereas large anterior skull base defects were reconstructed using a fascia lata sheath. Reconstruction was achieved without the support of bone graft or titanium mesh and without pericranial, galeal, or free flaps. Pericranial flap wrapping of the frontonasoorbital segment was performed to prevent osteoradionecrosis if postoperative radiotherapy was planned. The incidence of cerebrospinal fluid (CSF) leakage, intracranial infection, and tension pneumocephalus was 5.6%. Histopathological examination of fascia lata grafts obtained in patients who had undergone a second procedure demonstrated integration of vascularized fibrous tissue to the graft, as well as local proliferation of a newly formed vascular layer embedding the fascial sheath. Conclusions The use of a double-layer fascial graft alone was adequate for prevention of CSF leakage, meningitis, tension pneumocephalus, and brain herniation. The double-layer fascial flap provided a simple and reliable means for anterior skull base reconstruction after en bloc resection of both malignant and benign tumors.
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Thèses sur le sujet "Via Lata"

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BAGLIONE, CHIARA. « Pietro da Cortona, Alessandro 7. e la chiesa di Santa Maria in via Lata a Roma ». Doctoral thesis, Università IUAV di Venezia, 2000. http://hdl.handle.net/11578/278439.

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Wang, Wei. « Late-Stage Peptide Diversification via Transition Metal-Catalyzed C─H Activation ». Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-14AE-1.

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Martin, Carlos Frederico Barrere. « A via crucis da consciência em O braço direito de Otto Lara Resende ». Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/8/8151/tde-17042014-122805/.

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Propomos neste trabalho realizar uma análise do romance O braço direito, de Otto Lara Resende, tomando por base uma imagem recorrente na narrativa, a clausura, cuja força pode ser auferida na leitura pelo que constitui de elemento ordenador da estrutura do livro e principalmente do personagem narrador. O primeiro capítulo retoma o histórico da escritura do romance. Otto foi um autor que continuava a trabalhar o texto mesmo depois de publicado. O braço direito foi editado em 1963, relançado por duas vezes sem qualquer alteração, e reeditado em 1993 inteiramente reescrito. A relação do narrador com a escritura, que ganha forma num gênero literário subjacente à narrativa, o diário íntimo, é analisada no segundo capítulo. Tal relação incorpora em seu desenvolvimento marcas de uma opressão que perfazem o cotidiano do narrador e se traduzem no que escreve, como procuramos mostrar, pela manutenção dessa opressão, ao mesmo tempo em que escrever proporciona um espaço de reflexão. Depois de estudada essa relação, passamos no terceiro capítulo a outras formas de convivência, nas quais se observa a dimensão violenta e psicologicamente devastadora do meio social representado no livro, estando o narrador submetido a autoridades de toda ordem. No quarto e último capítulo abordamos o seu ambiente familiar, o impacto desse ambiente numa consciência que se constrói no centro de duas perspectivas conflitantes, e por conseguinte, de elementos que suscitam nela um embate intenso dos instintos, sobretudo os sexuais, com a auto-imposição de obedecer a um ideário conservador.
We propose in this paper to develop an analysis of the novel O braço direito, Otto Lara Resende, being based on a recurring image along the narrative, the cloister, whose strength can be understood in the reading by what it constitutes as an organizing element of the book structure especially the narrator character. The first chapter discusses the historical writing of the novel. Otto was an author who continued to work even after the text was published. O braço direito was published in 1963, reissued twice without any change, and reissued in 1993 entirely rewritten. The relationship between the narrator and the writing, which is shapped by a literary genre that underlies the narrative, the diary, is analyzed in the second chapter. Such relationship incorporates in its development some signs of oppression that make up the daily life of the narrator and are translated into his writing, as we intend to show, by maintaining such oppression, whereas writing that provides a space for reflection. After studying this relationship, we observe, in the third chapter, other ways of experiences, such as the violent side and psychologically devastating social environment depicted in the book, being the narrator submitted to authorities of all kinds. In the fourth and final chapter we discuss his family environment, its the impact on a consciousness that is built in the center of two conflicting perspectives, and therefore of elements that arouse in it a clash of strong instincts, especially sexual ones, with the self-imposition of obeying to a conservative ideology.
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Wang, Wei [Verfasser]. « Late-Stage Peptide Diversification via Transition Metal-Catalyzed C─H Activation / Wei Wang ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1219731714/34.

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Mendes, Luís Augusto Lobão. « Treinamento baseado em tecnologia via internet, aplicado nos cursos de especialização "Lato Sensu" ». Florianópolis, SC, 2002. http://repositorio.ufsc.br/xmlui/handle/123456789/83952.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.
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O presente trabalho tem como objetivo analisar a utilização da Internet como ferramenta educacional, apresentando uma experiência realizada nos cursos de Especialização Lato Sensu da Fundação Dom Cabral FDC. Aborda a fundamentação teórica das questões pedagógicas, tecnológicas e de interatividade que serviram para o desenvolvimento do site, bem como a influência dos softwares utilizados na educação, demonstrando como esta influência realça a sua importância para o desenvolvimento do aprendiz, levando em consideração os fundamentos sobre o treinamento e a aprendizagem do aluno adulto. A pesquisa realizada permitiu verificar e comparar os diversos softwares disponíveis e suas funcionalidades, possibilitando o desenvolvimento de uma solução exclusiva. Pretende-se, portanto, relatar os princípios que nortearam a construção deste site educacional, tais como, a metodologia, os recursos e os resultados obtidos.
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Garcia, Daniele Munhoz [UNESP]. « Som e vida após a lata : construção de instrumentos musicais com material alternativo ». Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108809.

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Este trabalho buscou verificar a interferência da construção de instrumentos musicais com material alternativo como solução para a crença dos estudantes na impossibilidade de praticar música e na ideia de que o ato de tocar esteja condicionado à aquisição de um instrumento musical, modificando o que pensam sobre a ideia de tocar instrumentos e fortalecendo, dessa forma, a sua crença na própria capacidade. Os resultados foram obtidos por meio de pesquisa de campo com entrevistas, observação de oficinas de construção de instrumentos musicais com material alternativo e análise de documentos sobre o assunto, além da triangulação dessas fontes pelo método qualitativo. Concluiu-se que para se obter um resultado positivo é necessário ter uma pré-conscientização ou ao menos a não instalação de um pensamento limitador em relação à pratica musical, em primeira instância uma experiência fácil e exitosa com instrumentos de simples execução, além da rede social que a incentive e o tempo como fator importante para mudança. Foram verificadas quatro oficinas que apresentaram resultados que confirmaram a hipótese, duas de forma mais expressiva, o que corrobora a construção de instrumentos musicais com material alternativo como uma ferramenta possível para o ensino de música voltado a necessidades dos estudantes, como elemento facilitador da prática musical e como oportunidade de desenvolvimento pessoal além da música
This paper aimed to verify the interference of the construction of musical instruments with alternative material as a solution to students’ belief in the inability to practice music, and in the idea that the act of playing is conditioned on acquisition of a musical instrument, changing what they think about playing instruments and empowering this way their belief of their own capacity. The results were obtained through field research with interviews, observation workshops of musical instruments with alternative material and analysis of documents about the subject, and the triangulation of these sources by the qualitative method. It was concluded that to obtain a positive result it is necessary to have a pre-consciousness or at least not to install a limiting thought in relation to musical practice, in first instance an easy and successful experience with tools simple to perform, as well as social network that encourages and time as an important factor for changing. It was verified that four workshops presented results confirming the hypothesis, two in a more significant, which supports the construction of musical instruments with alternative material as a possible tool for teaching music geared to the needs of students, as a facilitator of musical practice to them, and as an opportunity for personal development beyond the music
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Garcia, Daniele Munhoz. « Som e vida após a lata : construção de instrumentos musicais com material alternativo / ». São Paulo, 2013. http://hdl.handle.net/11449/108809.

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Orientador: Paulo Augusto Castagna
Coorientador: Lia Tomás
Banca: Paulo Roxo Barja
Banca: Sonia Regina Albano de Lima
Resumo: Este trabalho buscou verificar a interferência da construção de instrumentos musicais com material alternativo como solução para a crença dos estudantes na impossibilidade de praticar música e na ideia de que o ato de tocar esteja condicionado à aquisição de um instrumento musical, modificando o que pensam sobre a ideia de tocar instrumentos e fortalecendo, dessa forma, a sua crença na própria capacidade. Os resultados foram obtidos por meio de pesquisa de campo com entrevistas, observação de oficinas de construção de instrumentos musicais com material alternativo e análise de documentos sobre o assunto, além da triangulação dessas fontes pelo método qualitativo. Concluiu-se que para se obter um resultado positivo é necessário ter uma pré-conscientização ou ao menos a não instalação de um pensamento limitador em relação à pratica musical, em primeira instância uma experiência fácil e exitosa com instrumentos de simples execução, além da rede social que a incentive e o tempo como fator importante para mudança. Foram verificadas quatro oficinas que apresentaram resultados que confirmaram a hipótese, duas de forma mais expressiva, o que corrobora a construção de instrumentos musicais com material alternativo como uma ferramenta possível para o ensino de música voltado a necessidades dos estudantes, como elemento facilitador da prática musical e como oportunidade de desenvolvimento pessoal além da música
Abstract: This paper aimed to verify the interference of the construction of musical instruments with alternative material as a solution to students' belief in the inability to practice music, and in the idea that the act of playing is conditioned on acquisition of a musical instrument, changing what they think about playing instruments and empowering this way their belief of their own capacity. The results were obtained through field research with interviews, observation workshops of musical instruments with alternative material and analysis of documents about the subject, and the triangulation of these sources by the qualitative method. It was concluded that to obtain a positive result it is necessary to have a pre-consciousness or at least not to install a limiting thought in relation to musical practice, in first instance an easy and successful experience with tools simple to perform, as well as social network that encourages and time as an important factor for changing. It was verified that four workshops presented results confirming the hypothesis, two in a more significant, which supports the construction of musical instruments with alternative material as a possible tool for teaching music geared to the needs of students, as a facilitator of musical practice to them, and as an opportunity for personal development beyond the music
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Riemann, Lara [Verfasser]. « Termination Kinetics of Radical Homo- and Copolymerizations Studied via Time-Resolved EPR Spectroscopy / Lara Riemann ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1235222764/34.

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Pierpont, Aaron. « Computational Study of Small Molecule Activation via Low-Coordinate Late First-Row Transition Metal Complexes ». Thesis, University of North Texas, 2010. https://digital.library.unt.edu/ark:/67531/metadc28462/.

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Methane and dinitrogen are abundant precursors to numerous valuable chemicals such as methanol and ammonia, respectively. However, given the robustness of these substrates, catalytically circumventing the high temperatures and pressures required for such transformations has been a challenging task for chemists. In this work, computational studies of various transition metal catalysts for methane C-H activation and N2 activation have been carried out. For methane C-H activation, catalysts of the form LnM=E are studied, where Ln is the supporting ligand (dihydrophosphinoethane or β-diketiminate), E the activating ligand (O, NCH3, NCF3) at which C-H activation takes place, and M the late transition metal (Fe,Co,Ni,Cu). A hydrogen atom abstraction (HAA) / radical rebound (RR) mechanism is assumed for methane functionalization (CH4 à CH3EH). Since the best energetics are found for (β-diket)Ni=O and (β-diket)Cu=O catalysts, with or without CF3 substituents around the supporting ligand periphery, complete methane-to-methanol cycles were studied for such systems, for which N2O was used as oxygen atom transfer (OAT) reagent. Both monometallic and bimetallic OAT pathways are addressed. Monometallic Fe-N2 complexes of various supporting ligands (LnFe-N2) are studied at the beginning of the N2 activation chapter, where the effect of ligand on N2 activation in end-on vs. side-on N2 isomers is discussed. For (β-diket)Fe-N2 complexes, the additional influence of diketiminate donor atom (N(H) vs. S) is briefly addressed. The remainder of the chapter expands upon the treatment of β-diketiminate complexes. First, the activation and relative stabilities of side-bound and end-bound N2 isomers in monometallic ((β-diket)M-N2) and bimetallic ((β-diket)M-N2-M(β-diket)) first row transition metal complexes are addressed. Second, the thermodynamics of H/H+/H- addition to (β-diket)Fe-bound N2, followed by subsequent H additions up to release of ammonia, is discussed, for which two mechanisms (distal and alternating) are considered. Finally, the chapter concludes with partial distal and alternating mechanisms for H addition to N2 in bimetallic (β-diket)Fe-N2-Fe(β-diket) and (β-diket)M-N2-M(β-diket) (M = Ti,V,Fe), respectively.
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Joseph, Francine Pinto da Silva. « Territorialidade e Direito Étnico na Comunidade Negra Rural Vila da Lata - Aceguá, Fronteira Brasil/Uruguai ». Universidade Federal de Pelotas, 2010. http://repositorio.ufpel.edu.br:8080/handle/prefix/3319.

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A presente dissertação tem, como universo empírico, a Comunidade Negra Rural Vila da Lata, situada na cidade de Aceguá/Brasil, no estado do Rio Grande do Sul, pertencente à mesorregião do Sudoeste Rio-grandense e à microrregião da Campanha Meridional, fazendo fronteira com Aceguá/Uruguai. A autodefinição como remanescente de quilombos, por parte dessa comunidade, instigou o estudo de alguns aspectos que cerceiam a construção do território étnico no transcorrer do tempo. Assim, a pesquisa etnográfica tem, como objetivo central apreender o processo de construção da territorialidade na Comunidade Negra Rural Vila da Lata frente ao Direito Étnico. Para tanto, o presente texto procura primeiramente fazer uma abordagem teórico-metodológica. Em um segundo momento será feita uma análise sobre a presença do negro no Brasil, dando ênfase para o estado do Rio Grande do Sul. Na sequência, será realizada uma abordagem dos afrodescendentes na região de fronteira. No terceiro capítulo, será feita uma descrição sobre a apropriação e a consolidação da territorialidade negra expressa pelo grupo étnico no transcorrer do estudo. Ao final, analisar-se-à foi analisada a problemática surgida a partir da promulgação da Constituição Federal de 1988 e ocasionada pelo artigo 68 do Ato de Disposições Constitucionais Transitórias (ADCT) que trata da regulamentação das terras dos remanescentes de comunidades de quilombos e que assegura o direito étnico territorial para a comunidade mencionada.
Ce travail a comme l'univers empirique, la Communauté Noire Rural "Vila da Lata", situé dans la ville de Aceguá / Brésil dans l'état de Rio Grande do Sul, appartenant à la région moyenne du Sud-Ouest de Rio Grande et à la micro-région de la Campagne du Sud, dans la frontière entre Aceguá/Uruguay. L'auto-définition comme "remanescente de Quilombo", par cette communauté, a exhorté l'étude de certains aspects qui limitent la construction du territoire ethnique dans le cours du temps. Ainsi, la recherche ethnographique a pour principal objectif de saisir le processus de construction territoriale de la Communauté Rurale Noire Vila da Lata en face du droit ethnique. À cette fin, ce texte cherche d'abord à faire une approche théorique et méthodologique. Dans un second temps, fera une analyse sur la présence des noirs au Brésil, en mettant l'accent sur l'état de Rio Grande do Sul. En suite, il y aura un débat afro-descendents (d'ascendance africaine) dans la région frontalière. Dans le troisième chapitre, une description sera faite sur l`appropriation et la consolidatio de la territorialité noir exprimé par le groupe ethnique dans le cadre de l'étude. Enfin, qu`il a examiné la question découlant de l`adoption de la Constitution Fédérale de 1988 et occasionnés par l`article 68 de la Loi sur les Dispositions Constitutionnelles (ADCT), qui traite de la réglementation de la terre des "remanescentes" de communautés "quilombos" et que garantit le droit ethnique des territoires à la communauté mentionnés.
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Livres sur le sujet "Via Lata"

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Sandro, Benedetti, dir. La facciata di S. Maria in via Lata : Committenza, iconologia, proporzionamento, ordini. Roma : Quasar, 2006.

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D'Onofrio, Cesare. Il Facchino di via Lata ed altre fontane minori con acqua di Trevi. Roma : Romana società editrice, 1991.

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Episcopo, Silvana. Il Titulus Marcelli sulla via Lata : Nuovi studi e ricerche archeologiche, 1990-2000. Roma : Palombi, 2003.

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Cesare, D'Onofrio. Il Facchino di Via Lata ed altre fontane minori con acqua di Trevi. Roma : Romana Società Editrice, 1991.

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Francesco, Gandolfo, dir. Il Titulus Marcelli sulla via Lata : Nuovi studi e ricerche archeologiche, 1990-2000. Roma : Palombi, 2003.

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La chiesa di Santa Maria in via Lata : Note di storia e di restauro. Rome : Gangemi Editore, 2010.

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Francesco, Benelli, Sambin De Norcen, Maria Teresa et Schofield Richard V, dir. Nuovi antichi : Committenti, cantieri, architetti 1400-1600. Milano : Electa, 2004.

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Raniere, Édio. O jardim das ilusões. Blumenau : Fundo Municipal de Apoio à Cultura, 2007.

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Virginia, Burrus, dir. Late ancient Christianity. Minneapolis : Fortress Press, 2005.

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Pollard, A. J. Late medieval England, 1399-1509. New York : Longman, 2000.

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Chapitres de livres sur le sujet "Via Lata"

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Pascoe, K. J., W. D. Wood, P. S. Maybeck et A. W. Wood. « Target Recognition Via Late Time Scattering ». Dans Ultra-Wideband, Short-Pulse Electromagnetics 6, 463–70. Boston, MA : Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9146-1_43.

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Goodall, Brian L. « Cycloaliphatic Polymers via Late Transition Metal Catalysis ». Dans Late Transition Metal Polymerization Catalysis, 101–54. Weinheim, FRG : Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527601805.ch4.

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Trench, Máximo, et Ricardo A. Minervino. « Boosting Retrieval Via Target Elaborations (the “Late Abstraction Principle”) ». Dans SpringerBriefs in Psychology, 99–118. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52545-3_7.

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Pascoe, Kenneth J., et William D. Wood. « Pole Estimation for Target Recognition via Late Time Scattering ». Dans Ultra-Wideband, Short-Pulse Electromagnetics 7, 699–706. New York, NY : Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-37731-5_74.

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Sun, Wen-Hua. « Novel Polyethylenes via Late Transition Metal Complex Pre-catalysts ». Dans Advances in Polymer Science, 163–78. Berlin, Heidelberg : Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/12_2013_212.

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Stefanidi, Zinovia, Asterios Leonidis et Margherita Antona. « A Multi-stage Approach to Facilitate Interaction with Intelligent Environments via Natural Language ». Dans HCI International 2019 – Late Breaking Posters, 67–77. Cham : Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-30712-7_9.

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Kikuchi, Seiji, Ryosuke Konishi, Reiji Goda, Yusuke Kan’no, Shinji Miyake et Daiji Kobayashi. « Evaluation of a Virtual Working Environment via Psychophysiological Indices ». Dans HCI International 2022 - Late Breaking Papers. Design, User Experience and Interaction, 257–66. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-17615-9_18.

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Cardinali, Daniel Pedro. « The Beginnings of the Pineal Scientific Era : From the Late Nineteenth Century to Melatonin’s Discovery ». Dans Ma Vie en Noir, 23–31. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-41679-3_3.

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Bullock, R., P. Statham, J. Patterson, G. M. Teasdale, E. Teasdale et D. Wyper. « Tomographic Mapping of CBF, CBV and Blood Brain Barrier Changes in Humans After Focal Head Injury Using SPECT-Mechanisms for Late Deterioration ». Dans Intracranial Pressure VII, 637–39. Berlin, Heidelberg : Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73987-3_165.

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Van De Wetering, Ernst. « The 'late Rembrandt', first phase (1651-1659) ». Dans A Corpus of Rembrandt Paintings VI, 340–409. Dordrecht : Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-9240-0_8.

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Actes de conférences sur le sujet "Via Lata"

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Proso, Maja. « PRAVNI POLOŽAJ POTROŠAČA U UGOVORIMA NA DALjINU ». Dans XV Majsko savetovanje : Sloboda pružanja usluga i pravna sigurnost. University of Kragujevac, Faculty of Law, 2019. http://dx.doi.org/10.46793/xvmajsko.835p.

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In the paper the author analyses distance contracts with a special emphasis on distance contract via telephone, lays out the legal framework of the distance contracts at the European and national level, analyses de lege lata exsisting legal framework of distance contracts, specially those via telephone in the exsisting Consumer protection Act, amendmends of which came into force in February 2019, analyses consumer legal position in consumer disputes considering distance contracts, as well as proposes de lege ferenda certain legal solutions that would further enhance the legal regulation of distance contracts, as well as strengthen the position of consumers within contracts that are made remotely via phone.
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Torres, Frank Sill, Claas Cornelius et Dirk Timmermann. « Reliability enhancement via Sleep Transistors ». Dans 2011 12th Latin American Test Workshop - LATW. IEEE, 2011. http://dx.doi.org/10.1109/latw.2011.5985901.

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Lee, Yu-Wei, et Nur A. Touba. « Improving logic obfuscation via logic cone analysis ». Dans 2015 16th Latin-American Test Symposium (LATS). IEEE, 2015. http://dx.doi.org/10.1109/latw.2015.7102410.

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Isaza-Gonzalez, Jose, Alejandro Serrano-Cases, Felipe Restrepo-Calle, Sergio Cuenca-Asensi et Antonio Martinez-Alvarez. « Dependability evaluation of COTS microprocessors via on-chip debugging facilities ». Dans 2016 17th Latin-American Test Symposium (LATS). IEEE, 2016. http://dx.doi.org/10.1109/latw.2016.7483335.

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Pasca, Vladimir, Lorena Anghel et Mounir Benabdenbi. « Configurable Thru-Silicon-Via interconnect Built-In Self-Test and diagnosis ». Dans 2011 12th Latin American Test Workshop - LATW. IEEE, 2011. http://dx.doi.org/10.1109/latw.2011.5985896.

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Almukhaizim, Sobeeh, Eman AlQuraishi et Ozgur Sinanoglu. « Test power reduction via deterministic alignment of stimulus and response bits ». Dans 2011 12th Latin American Test Workshop - LATW. IEEE, 2011. http://dx.doi.org/10.1109/latw.2011.5985911.

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Ramirez, Antonio Zenteno. « Power distribution network analysis using semi irregular plane shape approach and via modeling ». Dans 2015 16th Latin-American Test Symposium (LATS). IEEE, 2015. http://dx.doi.org/10.1109/latw.2015.7102517.

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Alvarez Q., Juan M., John A. Sanabria O. et Jose I. Garcia M. « Microservices-based architecture for fault diagnosis in tele-rehabilitation equipment operated via Internet ». Dans 2019 IEEE Latin American Test Symposium (LATS). IEEE, 2019. http://dx.doi.org/10.1109/latw.2019.8704556.

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Saeedi, Sepide, Alessio Carpegna, Alessandro Savino et Stefano Di Carlo. « Prediction of the Impact of Approximate Computing on Spiking Neural Networks via Interval Arithmetic ». Dans 2022 IEEE 23rd Latin American Test Symposium (LATS). IEEE, 2022. http://dx.doi.org/10.1109/lats57337.2022.9936999.

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Haghani, Zahra, et Shahab Shahidi. « Late-time acceleration via mimetic Galileon gravity ». Dans Proceedings of the MG14 Meeting on General Relativity. WORLD SCIENTIFIC, 2017. http://dx.doi.org/10.1142/9789813226609_0107.

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Rapports d'organisations sur le sujet "Via Lata"

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Motel-Klingebiel, Andreas, et Gerhard Naegele. Exclusion and inequality in late working life in the political context of the EU. Linköping University Electronic Press, novembre 2022. http://dx.doi.org/10.3384/9789179293215.

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European societies need to increase the participation in work over the life course to support the provision of qualified labour and to meet the challenges for social security systems under the condition of their ageing populations. One of the key ambitions is to extend people’s working lives and to postpone labour market exit and retirement where possible. This requires informed policies, and the research programme EIWO – ‘Exclusion and Inequality in Late Working Life: Evidence for Policy Innovation towards Inclusive Extended Work and Sustainable Working Conditions in Sweden and Europe’ – aims to push the boundaries of knowledge about late working life and the potential of its inclusive and equal prolongation via a theoretically driven, gender-sensitive combination of multi-level perspectives. EIWO takes a life course approach on exclusion and inequality by security of tenure, quality of work, workplaces, and their consequences. It identifies life course policies, promoting lifelong learning processes and flexible adaptation to prolong working lives and to avoid increased exclusion and inequality. Moreover, it provides evidence for policies to ensure both individual, company and societal benefits from longer lives. To do so, EIWO orientates its analyses systematically to the macro-political contexts at the European Union level and to the policy goals expressed in the respective official statements, reports and plans. This report systematizes this ambitious approach. Relevant documents such as reports, green books and other publications of the European Commission (EC), the European Parliament (EP), the Organisation for Economic Co-operation and Development (OECD), as well as those of social partners and research institutions, have been systematically scanned and evaluated. In addition, relevant decisions of European summits have been considered. The selection of documents claims completeness regarding relevant and generally available publication, while relevance is defined from the point of view of EIWO’s interests. It is the aim of this report to provide a sound knowledge base for EIWO’s analyses and impact strategies and to contribute to the emerging research on the connection between population ageing and the European policies towards productivity, inclusiveness, equity, resilience and sustainability. This report aims to answer the following questions: How are EIWO’s conceptual classification and programme objectives reflected in the European Union’s policy programming? How can EIWO’s analyses and impact benefit from a reference to current EU policy considerations, and how does this focus support the outline of policy options and the formulating of possible proposals to Swedish and European stakeholders? The present report was written during early 2022; analyses were finalized in February 2022 and represent the status until this date.
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Kontak, D. J., S. Paradis, Z. Waller et M. Fayek. Petrographic, fluid inclusion, and secondary ion mass spectrometry stable isotopic (O, S) study of Mississippi Valley-type mineralization in British Columbia and Alberta. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/327994.

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A comprehensive study of Mississippi Valley-type base-metal deposits across the Canadian Cordillera was done to compare and contrast their features. Extensive dissolution of host rocks is followed by multiple generations of dolomite cements from early, low-temperature, fine-grained to coarser, higher temperature types that overlap with Zn-Pb sulfide minerals; late-stage calcite occludes residual porosity. Dolomite is generally chemically stoichiometric, but ore-stage types are often rich in Fe (<1.3 weight per cent FeO) with small sphalerite inclusions. Sphalerite-hosted fluid inclusions record ranges for homogenization temperatures (77-214°C) and fluid salinity (1-28 weight per cent equiv. NaCl±CaCl2). These data suggest fluid mixing with no single fluid type related to all sulfide mineralization. In situ secondary ion mass spectrometry (SIMS) generated delta-18OVSMOW values for carbonate minerals (13-33 permille) reflect dolomite and calcite formation involving several fluids (seawater, basinal, meteoric) over a large temperature range at varying fluid-rock ratios. Sphalerite and pyrite SIMS delta-34SVCDT values vary (8-33 permille) but in single settings have small ranges (<2-3 permille) that suggest sulfur was reduced via thermochemical sulfate reduction from homogeneous sulfur reservoirs. Collectively, the data implicate several fluids in the mineralizing process and suggest mixing of a sulfur-poor, metal-bearing fluid with a metal-poor, sulfide-bearing fluid.
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Manor, M. J., et S. J. Piercey. Whole-rock lithogeochemistry, Nd-Hf isotopes, and in situ zircon geochemistry of VMS-related felsic rocks, Finlayson Lake VMS district, Yukon. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328992.

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The Finlayson Lake district in southeastern Yukon is composed of a Late Paleozoic arc-backarc system that consists of metamorphosed volcanic, plutonic, and sedimentary rocks of the Yukon-Tanana and Slide Mountain terranes. These rocks host >40 Mt of polymetallic resources in numerous occurrences and styles of volcanogenic massive sulphide (VMS) mineralization. Geochemical and isotopic data from these rocks support previous interpretations that volcanism and plutonism occurred in arc-marginal arc (e.g., Fire Lake formation) and continental back-arc basin environments (e.g., Kudz Ze Kayah formation, Wind Lake formation, and Wolverine Lake group) where felsic magmatism formed from varying mixtures of crust- and mantle-derived material. The rocks have elevated high field strength element (HFSE) and rare earth element (REE) concentrations, and evolved to chondritic isotopic signatures, in VMS-proximal stratigraphy relative to VMS-barren assemblages. These geochemical features reflect the petrogenetic conditions that generated felsic rocks and likely played a role in the localization of VMS mineralization in the district. Preliminary in situ zircon chemistry supports these arguments with Th/U and Hf isotopic fingerprinting, where it is interpreted that the VMS-bearing lithofacies formed via crustal melting and mixing with increased juvenile, mafic magmatism; rocks that were less prospective have predominantly crustal signatures. These observations are consistent with the formation of VMS-related felsic rocks by basaltic underplating, crustal melting, and basalt-crustal melt mixing within an extensional setting. This work offers a unique perspective on magmatic petrogenesis that underscores the importance of integrating whole-rock with mineral-scale geochemistry in the characterization of VMS-related stratigraphy.
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Mueller, C., S. J. Piercey, M. G. Babechuk et D. Copeland. Stratigraphy and lithogeochemistry of rocks from the Nugget Pond Deposit area, Baie Verte Peninsula, Newfoundland. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328989.

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Stratigraphic and lithogeochemical data were collected from selected drill core from the Nugget Pond gold deposit in the Betts Cove area, Newfoundland. The stratigraphy consists of a lower unit of basaltic rocks that are massive to pillowed (Mount Misery Formation). This is overlain by sedimentary rocks of the Scrape Point Formation that consist of lower unit of turbiditic siltstone and hematitic cherts/iron formations (the Nugget Pond member); the unit locally has a volcaniclastic rich-unit at its base and grades upwards into finer grained volcaniclastic/turbiditic rocks. This is capped by basaltic rocks of the Scrape Point Formation that contain pillowed and massive mafic flows that are distinctively plagioclase porphyritic to glomeroporphyritic. The mafic rocks of the Mount Misery Formation have island arc tholeiitic affinities, whereas Scrape Point Formation mafic rocks have normal mid-ocean ridge (N-MORB) to backarc basin basalt (BABB) affinities. One sample of the latter formation has a calc-alkalic affinity. All of these geochemical features are consistent with results and conclusions from previous workers in the area. Clastic sedimentary rocks and Fe-rich sedimentary rocks of the Scrape Point Formation have features consistent with derivation from local, juvenile sources (i.e., intra-basinal mafic rocks). The Scrape Point Formation sedimentary rocks with the highest Fe/Al ratios, inferred to have greatest amount of hydrothermally derived Fe, have positive Ce anomalies on Post-Archean Australian Shale (PAAS)-normalized trace element plots. These features are consistent with having formed via hydrothermal venting into an anoxic/ sub-oxic water column. Further work is needed to test whether these redox features are a localized feature (i.e., restricted basin) or a widespread feature of the late Cambrian-early Ordovician Iapetus Ocean, as well as to delineate the role that these Fe-rich sedimentary rocks have played in the localization of gold mineralization within the Nugget Pond deposit.
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Mills, Stephanie E., et Bear Jordan. Uranium and Vanadium Resources of Utah : An Update in the Era of Critical Minerals and Carbon Neutrality. Utah Geological Survey, septembre 2021. http://dx.doi.org/10.34191/ofr-735.

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Utah is the second largest vanadium producing state and the third largest uranium producing state in the United States. Carnotite, a primary ore mineral for both vanadium and uranium, was first discovered and used by Native Americans as a source of pigment in the Colorado Plateau hysiographic province of eastern Utah. Radioactive deposits have been ommercially mined in Utah since about 1900, starting with radium, followed by vanadium, and thenuranium. In 1952, the discovery of the Mi Vida mine in Utah’s Lisbon Valley mining district in San Juan County kicked off a uranium exploration rush across the Colorado Plateau. As a result, the United States dominated the global uranium market from the early 1950s to late 1970s. In the modern mining era, Utah is an important contributor to the domestic uranium and vanadium markets with the only operating conventional uranium-vanadium mill in the country, multiple uranium-vanadium mines on standby, and active uranium-vanadium exploration. Overall, Utah has produced an estimated 122 million lbs U3O8 and 136 million lbs V2O5 since 1904. Most of this production has been from the sandstone-hosted deposits of the Paradox Basin, with minor production from volcanogenic deposits and as byproducts from other operations across the state
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Snyder, Claire, Christina T. Yuan, Renee F. Wilson, Katherine Smith, Youngjee Choi, Paul C. Nathan, Allen Zhang et Karen A. Robinson. Models of Care That Include Primary Care for Adult Survivors of Childhood Cancer : A Realist Review. Agency for Healthcare Research and Quality (AHRQ), février 2022. http://dx.doi.org/10.23970/ahrqepcrealistmodelsofcare.

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Objectives. We had two aims: (1) identify and analyze models of survivorship care for adult survivors of childhood cancer that include primary care, and (2) identify available tools, training, and other resources for adult survivors of childhood cancer. Methods. For each aim, we used realist synthesis to provide insights on how and for whom, in what contexts, and via what mechanisms the models of care and resources we identified can be effective for adult survivors of childhood cancer. We developed an initial program theory through searches of the literature and discussions with Stakeholders. We then identified and summarized quantitative evidence that supported or refuted the theory and developed specific hypotheses about how contexts and mechanisms may interact to produce outcomes (i.e., “CMO” hypotheses). The final program theory and CMO hypotheses were presented to Stakeholders for feedback. Results. Our final refined theory describes how, within the overall environment, survivor and provider characteristics and facilitators/barriers interact to produce intermediate and final outcomes. We focus on the role of models of care and resources (e.g., care plans) in these interactions. The program theory variables seen most consistently in the literature include oncology care versus primary care, survivor and provider knowledge (i.e., survivor risks and needs), provider comfort treating childhood cancer survivors, communication and coordination between and among providers and survivors, and delivery/receipt of prevention and surveillance of late effects of original cancer treatment. In turn, these variables played the most prominent role in the seven CMO hypotheses (4 focused on survivors and 3 focused on providers) regarding what works for whom and in what circumstances. Conclusions. To enable models of care that include primary care for adult survivors of childhood cancer, there needs to be communication of knowledge to both survivors and primary care providers. Our program theory provides guidance on the ways this knowledge could be shared, including the role of resources in doing so, and our CMO hypotheses suggest how the relationships illustrated in our theory could be associated with survivors living longer and feeling better through high-value care.
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Saillant, Eric, Jason Lemus et James Franks. Culture of Lobotes surinamensis (Tripletail). Mississippi Department of Marine Resources, janvier 2014. http://dx.doi.org/10.18785/ose.001.

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The Tripletail, Lobotes surinamensis, is a pelagic fish found in tropical and sub-tropical waters of all oceans. Tripletails are often associated with floating debris and make frequent incursions in bays and estuaries where they are targeted by recreational fishermen. In Mississippi waters the species is typically present during the late spring and summer season that also correspond to the period of sexual maturation and spawning (Brown-Peterson and Franks 2001). Tripletail is appreciated as a gamefish but is also prized for its flesh of superior quality. The fast growth rate of juveniles in captivity documented by Franks et al. (2001) and the excellent quality of Tripletail flesh both contribute to the potential of this species for marine aquaculture. In addition, the production of cultured juveniles would be precious to develop a better understanding of the biology, early life history and habitat use of Tripletail larvae and juveniles, a topic largely undocumented to date, through experimental releases and controlled studies. The culture of tripletail thus supports the Tidelands Trust Fund Program through improved conservation of natural resources, potential enhancement of fisheries productivity and potential development of a new economic activity on the Gulf coast producing tripletail via aquaculture. The Objective of this project was to initiate development of methods and techniques needed to spawn captive held tripletail broodfish and raise their offspring to evaluate their growth and development in captivity. In this report we will present the results of studies aiming to develop methods and protocols for captive spawning of tripletail and the first data obtained on the early development of tripletail larvae. A major issue that was encountered with tripletail broodstock development during the project lied in the difficulties associated with identifying the sex of adults caught in the wild and candidates for being incorporated in mating sets for spawning. This issue was addressed during the course of the project by examining the potential of a non-lethal method of hormonal sexing. The results of these preliminary investigations are presented in the third part of this report. All protocols used in the project were determined with the guidance of the Institutional Animal Care and Use Committee (IACUC) of the University of Southern Mississippi (USM IACUC protocol number 10100108).
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Al-Qadi, Imad, Hasan Ozer, Mouna Krami Senhaji, Qingwen Zhou, Rebekah Yang, Seunggu Kang, Marshall Thompson et al. A Life-Cycle Methodology for Energy Use by In-Place Pavement Recycling Techniques. Illinois Center for Transportation, octobre 2020. http://dx.doi.org/10.36501/0197-9191/20-018.

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Worldwide interest in using recycled materials in flexible pavements as an alternative to virgin materials has increased significantly over the past few decades. Therefore, recycling has been utilized in pavement maintenance and rehabilitation activities. Three types of in-place recycling technologies have been introduced since the late 70s: hot in-place recycling, cold in-place recycling, and full-depth reclamation. The main objectives of this project are to develop a framework and a life-cycle assessment (LCA) methodology to evaluate maintenance and rehabilitation treatments, specifically in-place recycling and conventional paving methods, and develop a LCA tool utilizing Visual Basic for Applications (VBA) to help local and state highway agencies evaluate environmental benefits and tradeoffs of in-place recycling techniques as compared to conventional rehabilitation methods at each life-cycle stage from the material extraction to the end of life. The ultimate outcome of this study is the development of a framework and a user-friendly LCA tool that assesses the environmental impact of a wide range of pavement treatments, including in-place recycling, conventional methods, and surface treatments. The developed tool provides pavement industry practitioners, consultants, and agencies the opportunity to complement their projects’ economic and social assessment with the environmental impacts quantification. In addition, the tool presents the main factors that impact produced emissions and energy consumed at every stage of the pavement life cycle due to treatments. The tool provides detailed information such as fuel usage analysis of in-place recycling based on field data.
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9

Meidan, Rina, et Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, mars 1995. http://dx.doi.org/10.32747/1995.7604935.bard.

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The main goal of this research plan was to elucidate regulatory mechanisms controlling the development, function of the bovine corpus luteum (CL). The CL contains two different sterodigenic cell types and therefore it was necessary to obtain pure cell population. A system was developed in which granulosa and theca interna cells, isolated from a preovulatory follicle, acquired characteristics typical of large (LL) and small (SL) luteal cells, respectively, as judged by several biochemical and morphological criteria. Experiments were conducted to determine the effects of granulosa cells removal on subsequent CL function, the results obtained support the concept that granulosa cells make a substaintial contribution to the output of progesterone by the cyclic CL but may have a limited role in determining the functional lifespan of the CL. This experimental model was also used to better understand the contribution of follicular granulosa cells to subsequent luteal SCC mRNA expression. The mitochondrial cytochrome side-chain cleavage enzyme (SCC), which converts cholesterol to pregnenolone, is the first and rate-limiting enzyme of the steroidogenic pathway. Experiments were conducted to characterize the gene expression of P450scc in bovine CL. Levels of P450scc mRNA were higher during mid-luteal phase than in either the early or late luteal phases. PGF 2a injection decreased luteal P450scc mRNA in a time-dependent manner; levels were significantly reduced by 2h after treatment. CLs obtained from heifers on day 8 of the estrous cycle which had granulosa cells removed had a 45% reduction in the levels of mRNA for SCC enzymes as well as a 78% reduction in the numbers of LL cells. To characterize SCC expression in each steroidogenic cell type we utilized pure cell populations. Upon luteinization, LL expressed 2-3 fold higher amounts of both SCC enzymes mRNAs than SL. Moreover, eight days after stimulant removal, LL retained their P4 production capacity, expressed P450scc mRNA and contained this protein. In our attempts to establish the in vitro luteinization model, we had to select the prevulatory and pre-gonadotropin surge follicles. The ratio of estradiol:P4 which is often used was unreliable since P4 levels are high in atretic follicles and also in preovulatory post-gonadotropin follicles. We have therefore examined whether oxytocin (OT) levels in follicular fluids could enhance our ability to correctly and easily define follicular status. Based on E2 and OT concentrations in follicular fluids we could more accurately identify follicles that are preovulatory and post gonadotropin surge. Next we studied OT biosynthesis in granulosa cells, cells which were incubated with forskolin contained stores of the precursor indicating that forskolin (which mimics gonadotropin action) is an effective stimulator of OT biosynthesis and release. While studying in vitro luteinization, we noticed that IGF-I induced effects were not identical to those induced by insulin despite the fact that megadoses of insulin were used. This was the first indication that the cells may secrete IGF binding protein(s) which regonize IGFs and not insulin. In a detailed study involving several techniques, we characterized the species of IGF binding proteins secreted by luteal cells. The effects of exogenous polyunsaturated fatty acids and arachidonic acid on the production of P4 and prostanoids by dispersed bovine luteal cells was examined. The addition of eicosapentaenoic acid and arachidonic acid resulted in a dose-dependent reduction in basal and LH-stimulated biosynthesis of P4 and PGI2 and an increase in production of PGF 2a and 5-HETE production. Indomethacin, an inhibitor of arachidonic acid metabolism via the production of 5-HETE was unaffected. Results of these experiments suggest that the inhibitory effect of arachidonic acid on the biosynthesis of luteal P4 is due to either a direct action of arachidonic acid, or its conversion to 5-HETE via the lipoxgenase pathway of metabolism. The detailed and important information gained by the two labs elucidated the mode of action of factors crucially important to the function of the bovine CL. The data indicate that follicular granulosa cells make a major contribution to numbers of large luteal cells, OT and basal P4 production, as well as the content of cytochrome P450 scc. Granulosa-derived large luteal cells have distinct features: when luteinized, the cell no longer possesses LH receptors, its cAMP response is diminished yet P4 synthesis is sustained. This may imply that maintenance of P4 (even in the absence of a Luteotropic signal) during critical periods such as pregnancy recognition, is dependent on the proper luteinization and function of the large luteal cell.
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Roschelle, Jeremy, Britte Haugan Cheng, Nicola Hodkowski, Julie Neisler et Lina Haldar. Evaluation of an Online Tutoring Program in Elementary Mathematics. Digital Promise, avril 2020. http://dx.doi.org/10.51388/20.500.12265/94.

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Many students struggle with mathematics in late elementary school, particularly on the topic of fractions. In a best evidence syntheses of research on increasing achievement in elementary school mathematics, Pelligrini et al. (2018) highlighted tutoring as a way to help students. Online tutoring is attractive because costs may be lower and logistics easier than with face-to-face tutoring. Cignition developed an approach that combines online 1:1 tutoring with a fractions game, called FogStone Isle. The game provides students with additional learning opportunities and provides tutors with information that they can use to plan tutoring sessions. A randomized controlled trial investigated the research question: Do students who participate in online tutoring and a related mathematical game learn more about fractions than students who only have access to the game? Participants were 144 students from four schools, all serving low-income students with low prior mathematics achievement. In the Treatment condition, students received 20-25 minute tutoring sessions twice per week for an average of 18 sessions and also played the FogStone Isle game. In the Control condition, students had access to the game, but did not play it often. Control students did not receive tutoring. Students were randomly assigned to condition after being matched on pre-test scores. The same diagnostic assessment was used as a pre-test and as a post-test. The planned analysis looked for differences in gain scores ( post-test minus pre-test scores) between conditions. We conducted a t-test on the aggregate gain scores, comparing conditions; the results were statistically significant (t = 4.0545, df = 132.66, p-value < .001). To determine an effect size, we treated each site as a study in a meta-analysis. Using gain scores, the effect size was g=+.66. A more sophisticated treatment of the pooled standard deviation resulted in a corrected effect size of g=.46 with a 95% confidence interval of [+.23,+.70]. Students who received online tutoring and played the related Fog Stone Isle game learned more; our research found the approach to be efficacious. The Pelligrini et al. (2018) meta-analysis of elementary math tutoring programs found g = .26 and was based largely on face-to-face tutoring studies. Thus, this study compares favorably to prior research on face-to-face mathematics tutoring with elementary students. Limitations are discussed; in particular, this is an initial study of an intervention under development. Effects could increase or decrease as development continues and the program scales. Although this study was planned long before the current pandemic, results are particularly timely now that many students are at home under shelter-in-place orders due to COVID-19. The approach taken here is feasible for students at home, with tutors supporting them from a distance. It is also feasible in many other situations where equity could be addressed directly by supporting students via online tutors.
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