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1

Ignatiadis, Michail, Christos Sotiriou et Klaus Pantel, dir. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28160-0.

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2

International Symposium on the Effects of Therapy on the Biology and Kinetics of the Surviving Tumor (1989 Vancouver, B.C.). Effects of therapy on biology and kinetics of the residual tumor : Proceedings of an International Symposium on the Effects of Therapy on the Biology and Kinetics of the Surviving Tumor, held in Vancouver, British Columbia, Canada, February 15-18, 1989. Sous la direction de Ragaz J. 1945-. New York : Wiley-Liss, 1990.

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3

Mario, Dicato, Mathé Georges et Reizenstein Peter 1928-, dir. Management of minimal residual malignancy in man. Oxford : Pergamon, 1988.

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4

F, Zipf Theodore, et Johnston Dennis A, dir. Leukemia and lymphoma : Detection of minimal residual disease. Totowa, N.J : Humana Press, 2003.

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5

Pantel, Klaus, Michail Ignatiadis et Christos Sotiriou. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer. Springer, 2012.

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6

Pantel, Klaus, Michail Ignatiadis et Christos Sotiriou. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer. Springer London, Limited, 2012.

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7

Pantel, Klaus, Michail Ignatiadis et Christos Sotiriou. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer. Springer Berlin / Heidelberg, 2014.

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8

Minimal Residual Disease And Circulating Tumor Cells In Breast Cancer. Springer, 2012.

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9

Reizenstein, P., et G. Mathe. Managing Minimal Residual Malignancy in Man (Medical Oncology and Tumor Pharmacotherapy). Elsevier Science Publishing Company, 1989.

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10

Majmundar, Neil, et James K. Liu. Ventricular Tumors. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0009.

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Central neurocytomas are rare benign tumors that are typically located in the lateral ventricles. Because they are typically intraventricular, these tumors tend to present clinically with hydrocephalus. Currently, surgical removal with a gross-total resection is the treatment of choice. Various radiotherapy techniques, including both conventional radiotherapy and stereotactic radiosurgery, have been shown to be useful in cases of residual tumor after subtotal resection and tumor recurrence. This chapter presents a clinical case of central neurocytoma that demonstrates the typical clinical and radiological findings, as well as the diagnostic workup and surgical management of these tumors.
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11

Farghaly, Samir A. Adoptive Cell Immunotherapy for Epithelial Ovarian Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190248208.003.0005.

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The standard management for epithelial ovarian cancer (EOC) is a combination of aggressive debulking surgery with residual tumor of less than 1 cm and platinum-based chemotherapy. However, a high percentage of patients experience disease recurrence. Extensive efforts to find new therapeutic options have been made, albeit cancer cells develop drug resistance and malignant progression occurs. Novel therapeutic strategies are needed to enhance progression-free survival and overall survival of patients with advanced EOC. Several preclinical and clinical studies investigated feasibility and efficacy of adoptive cell therapy (ACT) in EOC. The aim of this chapter is to present an overview of ACT in EOC, focusing on Human Leukocyte Antigen (HLA)-restricted tumor infiltrating lymphocytes and MHC-independent immune effectors such as natural killer and cytokine-induced killer. The available data suggest that ACT may provide the best outcome in patients with low tumor burden, minimal residual disease, or maintenance therapy. Further preclinical studies and clinical trials are needed.
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12

CRUZ, V. F. R. Desempenho da ecografia mamária na identificação do tumor residual pós-quimioterapia primária e a concordância entre a aferição ultrassonográfica e histopatológica. Dialética, 2022. http://dx.doi.org/10.48021/978-65-252-5457-9.

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13

Ragez, Joseph, et J. Ragez. Effects of Therapy on Biology and Kinetics of the Residual Tumor, PT. a : Pre-Clinical Aspects (Progress in Clinical & Biological Resear). John Wiley & Sons, 1990.

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14

Ragez, Joseph, et J. Ragez. Effects of Therapy on Biology and Kinetics of the Residual Tumor : Proceedings of an International Symposium on the Effects of Therapy on the Biology a (Progress in Clinical & Biological Research). Wiley-Liss, 1990.

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15

Lee, Amie Y., et Bonnie N. Joe. Post-Lumpectomy/Post-Radiation Breast. Sous la direction de Christoph I. Lee, Constance D. Lehman et Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0062.

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Mammography is currently the primary imaging modality for post-operative evaluation and surveillance of the conservatively treated breast. Tumor recurrence has been shown to occur at a rate of approximately 1–2% per year, and the goal of imaging surveillance is to detect recurrent and new cancers at the earliest stages while avoiding unnecessary biopsies for characteristically benign findings. The radiologist should be familiar with the expected mammographic appearance and evolution of benign post-lumpectomy/post-radiation change, while also recognizing findings suspicious for residual and recurrent disease. This chapter, appearing in the section on intervention and surgical changes, reviews the key imaging and clinical features, imaging protocols and pitfalls, and clinical recommendations for the post-lumpectomy and post-radiation breast. Topics discussed include the evolution of benign post-surgical/post-radiation findings and the detection of suspicious lesions. The primary emphasis will be on mammographic surveillance. The role of ultrasound and MRI will also be discussed.
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16

(Editor), Pia Raanani, et Andreas Hochhaus (Editor), dir. Minimal Residual Disease In Hematologic Malignancies (Acta Haematologica 2004). Not Avail, 2004.

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17

Tilgen, W., et U. Reinhold. Minimal Residual Disease in Melanoma : Biology, Detection and Clinical Relevance. Springer London, Limited, 2012.

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18

Tilgen, W., et U. Reinhold. Minimal Residual Disease in Melanoma : Biology, Detection and Clinical Relevance. Springer London, Limited, 2011.

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19

Zipf, Theodore F., et Dennis A. Johnston. Leukemia and Lymphoma : Detection of Minimal Residual Disease. Humana Press, 2002.

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20

Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II : Adjuvant Therapies of the Various Primary Tumors. Springer, 2011.

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21

Bonadonna, Gianni, et Georges Mathé. Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease II : Adjuvant Therapies of the Various Primary Tumors. Brand : Springer, 2012.

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22

Jalali, Rakesih, Patrick Y. Wen et Takamitsu Fujimaki. Meningiomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0011.

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Meningiomas are the most common type of primary brain tumour, comprising approximately one-third of all intracranial neoplasms. It is therefore important for all neuro-oncologists to understand the biology and optimal managements of these tumours. The majority of meningiomas are World Health Organization grade I benign tumours, but grade II (atypical) or grade III (anaplastic) tumours are not uncommon. Total surgical removal is the standard of care but may not be feasible if the tumour involves critical structures such as cranial nerves or important blood vessels. Conventional radiation therapy, stereotactic radiosurgery, or particle irradiation is used for residual or recurrent tumours. To date, medical treatments have had a limited role, except for controlling seizures. However, there are ongoing clinical trials with molecularly targeted drugs and immunotherapies based on improved understanding of the molecular pathogenesis of these tumours. In this chapter, the clinical presentation, biology, and therapy for these tumours are discussed.
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23

Hoskin, Peter. Vulva and vagina. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199696567.003.0014.

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Chapter 9b discusses carcinoma of the vulva, which is primarily a surgical disease best treated by wide surgical resection, radical vulvectomy, and inguinal lymph node dissection based on presenting stage. Rarely, locally advanced primary disease may be presented for primary radiotherapy treatment. Postoperative radiotherapy is recommended for tumours invading >7 mm in a vertical direction. The first station regional lymph nodes in the inguinal region are best treated by radical surgical dissection, but fixed inoperable lymph nodes may benefit from primary radiotherapy which may be followed where appropriate by surgery if there is a residual mass. Postoperative radiotherapy should be considered for women having more than one node involved with metastatic tumour at surgery. This must be balanced against the increased risk of lymphoedema where both surgery and radiotherapy are delivered to the groins. Chemoradiation using cisplatin or 5-FU/mitomycin C-based schedules has been reported but no randomized comparison with radiotherapy alone has been undertaken; whilst high response rates are seen there is a considerable increase in acute toxicity.
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24

Gilbert, Mark R., et Roberta Rudà. Ependymal tumours. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0005.

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Ependymomas are uncommon central nervous system cancers that can arise in the supratentorial, infratentorial, or spinal cord region. Recently, there have been several seminal findings regarding the molecular profiles of ependymomas that have led to marked changes in the classification of this disease. In addition to the World Health Organization grading system that designates ependymomas based on histological appearance into grade I, II, or III, a new molecular classification with distinct entities within the three anatomical regions provides additional subtyping that has prognostic significance and may ultimately provide therapeutic targets. Ependymomas are typically treated with maximum safe tumour resection. Grade III tumours always require radiation treatment even with extensive resection. Radiation is also often administered to patients with grade II ependymomas. Grade I tumours typically receive radiation if there is extensive residual disease, but complete resection may be curative. Local radiation is optimal unless there is imaging or cytological evidence of dissemination in the cerebrospinal fluid. Chemotherapy is less well established although recent molecular findings may lead to subtype specific treatments.
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25

Cartwright, Kent. Shakespeare and the Comedy of Enchantment. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780198868897.001.0001.

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Shakespeare and the Comedy of Enchantment explores the encounter between comedy’s rationalizing dimensions and those extra-rational aspects that elude demystification and exert affective power, an encounter between what is explicable and what is inexplicable. In the context of modernist disenchantment, Shakespeare’s comedies showcase the play of wonder and doubt, leaving behind a sense of residual re-enchantment. The argument thus broadens the perspective of studies that align early modern comedy with developments in science and jurisprudence. As the comic action advances, elements of mystery accrue—uncanny coincidences; magical sympathies; inexplicable repetitions; psychic influences; and wonders, fears, and doubts about the meaning of events—all of whose effects linger after reason has apparently answered the play’s questions, leaving an aura of wonder and wondering. Comic enchantment works through certain devices, tropes, and motifs explored in the chapters: magical clowns who introduce non-realistic stop-time moments that alter the action; structural repetitions that suggest mysteriously converging destinies and opaque but providential outcomes; places with differing characteristics that frame encounters between the regulatory and the protean drives in human existence; desires, thoughts, and utterances that manifest comically monstrous realities, including objects and individuals; characters who return from the dead, facilitated by the desires of the living; play-endings that traffic in harmony and dissonance, yet which can make possible the irrational action of forgiveness. These matters are discussed with extensive reference to Renaissance and modern theories of comedy, and with comparisons to Italian and Tudor comedy.
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