Littérature scientifique sur le sujet « TSAPU »
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Articles de revues sur le sujet "TSAPU"
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Li, Yize, Nadezhda V. Terekhanova, Daniel Cui Zhou, Kelly V. Ruggles, Samuel H. Payne, Michael Wendl, David Fenyő et Li Ding. « Abstract 845 : Pan-cancer proteogenomic signatures associated with HRD, MSI, APOBEC, and smoking ». Cancer Research 82, no 12_Supplement (15 juin 2022) : 845. http://dx.doi.org/10.1158/1538-7445.am2022-845.
Texte intégralRésumé :
Abstract The increased quality and data availability of large-scale transcriptomic, genomic, and proteomic studies require a pan-cancer integrated proteogenomic approach to define tumor molecular signatures accurately and identify new therapeutic targets. We comprehensively investigate more than 1000 samples across 12 cancer types from the Clinical Proteomics Tumor Analysis Consortium (CPTAC) and the International Cancer Proteogenome Consortium (ICPC). The types are comprised of breast (BR), colorectal (CO), and ovarian (OV) cancers, clear cell renal cell (ccRCC), head and neck squamous cell (HNSCC), lung squamous cell (LSCC), hepatitis B virus (HBV)-related hepatocellular (HCC), and endometrial (EC) carcinomas, lung adenocarcinoma (LUAD), pancreatic ductal adenocarcinoma (PDAC), and glioblastoma (GBM). In particular, we examine 8 Tumor Signature Associated Phenotypes (TSAPs), namely aristolochic acid (AA), aging, microsatellite instability (MSI), homologous recombination deficiency (HRD), POLE, APOBEC, smoking, and ultraviolet (UV) light exposure. This study is the first to report proteomic markers associated with these TSAPs on a pan-cancer level. In addition to genetic alterations and mutational signatures, we utilize multi-omics data of high-resolution proteome, phosphoproteome, acetylome, and gene expression to infer expression signatures of TSAPs by defining the most critical changes in the transcriptome and proteome accompanying the transitions to these TSAPs, especially markers that were uniquely found in proteomic data. We consolidated multi-omic data and calculated the novel quantitative Tumor Signature Associated Phenotypes (TSAPs) score to predict the TSAP status. For example, the use of proteomic markers for MSI-TSAP scoring can improve clinical testing of MSI status. We further study environmental exposure-related tumor proteogenomic signatures, immune proteogenomic signatures, and the association between the immune subtypes and TSAPs. Smoking strongly influences the tumor immune microenvironment and disease prognosis. We show that expression signatures can facilitate the prediction of TSAPs and help to uncover their underlying molecular mechanisms. By connecting these findings with druggable databases, we provide a link to actionable therapies, identify putative TSAP-related targets, and offer novel cues to optimize therapeutic options for patients, such as how additional targeting of genes up-regulated in PARP1 inhibitor-treated HRD tumors may overcome resistance. This will promote the identification not only of unique druggable targets, but also to determine putative novel therapeutic targets using integrated approaches. Citation Format: Yize Li, Nadezhda V. Terekhanova, Daniel Cui Zhou, Kelly V. Ruggles, Samuel H. Payne, Michael Wendl, David Fenyő, Li Ding. Pan-cancer proteogenomic signatures associated with HRD, MSI, APOBEC, and smoking [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 845.
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Grandchamp, Bernard, Gilles Hetet, Caroline Kannengiesser, Claire Oudin, Carole Beaumont, Sylvie Rodrigues-Ferreira, Robert Amson et al. « A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene ». Blood 118, no 25 (15 décembre 2011) : 6660–66. http://dx.doi.org/10.1182/blood-2011-01-329011.
Texte intégralRésumé :
Abstract STEAP3/TSAP6 encodes a ferrireductase that is involved in the acquisition of iron by developing erythroblasts and steap3/tsap6 null-mice display severe microcytic anemia. We report a family in which 3 siblings born to healthy parents display transfusion-dependent hypochromic anemia. A nonsense STEAP3/TSAP6 was identified in the siblings at the heterozygous state. This mutation was inherited from their father while no mutation was found in their mother. A large variability of expression was found between normal alleles in a control population, confirming a previous report that STEAP3/TSAPS6 is an expressed quantitative trait locus (e-QTL). Determination of the relative allele expression showed that the “normal” allele was expressed at a significantly higher level in the father than in the affected siblings relative to the shared mutated allele. The blood level of STEAP3/TSAP6 mRNA was severely reduced in the siblings, while both parents were in the lower range of normal controls. The STEAP3/TSAP6 protein was also reduced in lymphocytic cell lines from the patients. Collectively, our data support the hypothesis that STEAP3/TSAP6 deficiency leads to severe anemia in the affected siblings and results from the combination of a mutated allele inherited from their father and a weakly expressed allele inherited from their mother.
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Benitez-Barrera, Carlos R., et Beatriz De Diego-Lázaro. « Servicios y Formación de los Técnicos Superiores en Audiología Protésica en España : Una Comparación con el Modelo de Audiólogo General ». Auditio 5, no 3 (30 décembre 2021) : e78. http://dx.doi.org/10.51445/sja.auditio.vol5.2021.0078.
Texte intégralRésumé :
La titulación de Técnico Superior en Audiología Protésica (TSAP) nació en España en el año 2001. Desde entonces, han surgido títulos propios de posgrado en audiología. Sin embargo, no existe aún en España el grado universitario de audiología general. El objetivo de este estudio fue examinar los lugares de trabajo, los servicios ofrecidos y la percepción de la formación de los TSAP con y sin formación universitaria y si éstos ejercían labores propias del audiólogo general propuesto por la Federación Europea de Sociedades Audiológicas (EFAS). Un cuestionario en línea fue completado por 255 TSAP. Se utilizaron análisis de varianza para comparar las respuestas entre TSAP sin formación complementaria, TSAP con grado de una disciplina afín a la audiología, TSAP con posgrado en audiología, y TSAP con ambos complementos. Independientemente de su nivel educativo, la mayoría de los TSAP indicaron desempeñar su labor profesional en centros auditivos adaptando audífonos a pacientes adultos, para lo cual percibieron estar suficientemente formados. Los TSAP con mayor nivel educativo indicaron trabajar en centros más especializados, así como atender a pacientes pediátricos con más frecuencia, y percibieron que su formación en implantes cocleares era mejor que los TSAP. En general, los TSAP no reciben formación ni ofrecen servicios en áreas que están dentro de las competencias del audiólogo general, tales como la programación de implantes cocleares o el diagnóstico de problemas vestibulares. Los estudios futuros deberán enfocarse en conocer la formación que reciben los profesionales que ofrecen este tipo de servicios audiológicos en España.
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Siewering, Katja, Samta Jain, Carmen Friedrich, Mariam T. Webber-Birungi, Dmitry A. Semchonok, Ina Binzen, Alexander Wagner et al. « Peptidoglycan-binding protein TsaP functions in surface assembly of type IV pili ». Proceedings of the National Academy of Sciences 111, no 10 (20 février 2014) : E953—E961. http://dx.doi.org/10.1073/pnas.1322889111.
Texte intégralRésumé :
Type IV pili (T4P) are ubiquitous and versatile bacterial cell surface structures involved in adhesion to host cells, biofilm formation, motility, and DNA uptake. In Gram-negative bacteria, T4P pass the outer membrane (OM) through the large, oligomeric, ring-shaped secretin complex. In the β-proteobacteriumNeisseria gonorrhoeae, the native PilQ secretin ring embedded in OM sheets is surrounded by an additional peripheral structure, consisting of a peripheral ring and seven extending spikes. To unravel proteins important for formation of this additional structure, we identified proteins that are present with PilQ in the OM. One such protein, which we name T4P secretin-associated protein (TsaP), was identified as a phylogenetically widely conserved component of the secretin complex that co-occurs with genes for T4P in Gram-negative bacteria. TsaP contains an N-terminal carbohydrate-binding lysin motif (LysM) domain and a C-terminal domain of unknown function. InN. gonorrhoeae, lack of TsaP results in the formation of membrane protrusions containing multiple T4P, concomitant with reduced formation of surface-exposed T4P. Lack of TsaP did not affect the oligomeric state of PilQ, but resulted in loss of the peripheral structure around the PilQ secretin. TsaP binds peptidoglycan and associates strongly with the OM in a PilQ-dependent manner. In the δ-proteobacteriumMyxococcus xanthus, TsaP is also important for surface assembly of T4P, and it accumulates and localizes in a PilQ-dependent manner to the cell poles. Our results show that TsaP is a novel protein associated with T4P function and suggest that TsaP functions to anchor the secretin complex to the peptidoglycan.
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Wang, Yi Chun, Zheng Wei Dai et Yuan Xue. « Synthesis and Characterization of Temperature-Sensitive TSPU/PNIPAAm Semi-IPN Polymer ». Advanced Materials Research 399-401 (novembre 2011) : 359–62. http://dx.doi.org/10.4028/www.scientific.net/amr.399-401.359.
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Thermo-sensitive polyurethane (TSPU) was synthesized from poly(ε-caprolactone) and 4,4’-methylenebis (phenyl isocyanate) by a two-step process with 1,4-butanediol as the chain extender. Following that, a novel temperature-sensitive material was created by the strategy of IPN from TSPU and PNIPAAm in the method of in situ polymerization. The chemical structure and thermo properties of the semi-IPN were characterized with FT-IR and DSC. The results prove that intensive inter-molecular interactions exist between TSPU and PNIPAAm chains, which have significant influence on the phase transition behaviors of the material. According to these results, the transition temperature of the semi-IPN can be adjusted in the range of 30~40 °C by controlling the composition of TSPU and the semi-IPNs.
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Yoshino, H., D. C. Curran-Everett, S. K. Hong et J. A. Krasney. « Altered heart rate-arterial pressure relation during head-out water immersion in conscious dog ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 254, no 4 (1 avril 1988) : R595—R601. http://dx.doi.org/10.1152/ajpregu.1988.254.4.r595.
Texte intégralRésumé :
The influence of head-out water immersion (WI) (37 degrees C) on baroreflex control of heart rate was studied in five trained, instrumented, conscious dogs. Arterial pressure was raised and lowered using occluder cuffs implanted around the aorta and inferior vena cava. Function curves relating transmural systolic arterial pressure (TSAP = systolic arterial pressure-pleural pressure) to heart rate (HR) were constructed to compare responses in air and during WI. The resting TSAP in air [142 +/- 8 mmHg (mean +/- SE) at 78 +/- 6 beats/min] increased significantly during WI (161 +/- 9 mmHg at 109 +/- 9 beats/min). During WI, the saturation TSAP at the bradycardia plateau of the relation increased significantly, by 19 mmHg, whereas the average gain (slope) of the relation decreased significantly, from -1.426 to -0.752 beats.min-1.mmHg-1. Therefore, WI elicits both a resetting and a decrease of the average gain of the TSAP-HR relation. The heart rate range increased during WI as well. After cholinergic blockade with atropine, WI did not elicit a resetting of the relation and the change in average gain was abolished. However, after beta 1-blockade with metoprolol, the resting TSAP increased significantly during WI and resetting persisted, but the decrease of average gain was abolished. Therefore, the alteration of the TSAP-HR relation in WI is achieved via a modulation of both adrenergic and cholinergic regulation of HR.
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Broner, Esther Channah, Hadil Onallah, Tali Tavor Re’em, Ben Davidson et Reuven Reich. « Role of the Exosome Secretion Machinery in Ovarian Carcinoma : In Vitro and In Vivo Models ». Journal of Oncology 2020 (30 mai 2020) : 1–11. http://dx.doi.org/10.1155/2020/4291827.
Texte intégralRésumé :
Objective. We recently reported on the expression and clinical role of molecules that mediate exosome secretion in high-grade serous carcinoma. In the present study, the biological role of these molecules was analyzed. Methods. OVCAR8 and ES-2 ovarian carcinoma cells were studied using a combination of CRISPR/Cas9 technology and two 3D in vitro models—spheroids emulating effusions and alginate scaffolds representing solid lesions. Isolation of exosomes was validated by electron microscopy. TSAP6, NSMASE2, RAB27A, and RAB27B mRNA and protein levels were analyzed using qRT-PCR and Western blotting, respectively. Tumor aggressiveness was studied in vitro using scratch assay, invasion assay, and matrix metalloproteinase (MMP) activity assay and in vivo using a mouse model. Results. In OVCAR8 cells, mRNA expression of TSAP6 and RAB27A was significantly higher in spheroids compared to scaffolds, whereas the opposite was true for NSMASE2 mRNA. In ES-2 cells, TSAP6 and RAB27B mRNA expression was significantly higher in spheroids versus scaffolds. In addition, nSMase2 and TSAP6 protein expression was significantly higher in scaffolds compared to spheroids. CRISPR-edited cells with silencing of NSMASE2, TSAP6, and RAB27A/B had reduced migration, invasion, and MMP activity. Additionally, knockout (KO) of these molecules resulted in significantly diminished exosome secretion. In vivo assay showed that when injected to mice, OVCAR8 RAB27A/B KO cells, as opposed to control OVCAR8 cells, did not form ascites or visible tumor lesions and had reduced MMP expression. Conclusion. The present study provides evidence that different models for culturing ovarian carcinoma cells affect the expression of molecules mediating exosome secretion and that these molecules have a tumor-promoting role. Silencing these molecules may consequently have therapeutic relevance in this cancer.
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Amzallag, Nathalie, Brent J. Passer, David Allanic, Elodie Segura, Clotilde Théry, Bruno Goud, Robert Amson et Adam Telerman. « TSAP6 Facilitates the Secretion of Translationally Controlled Tumor Protein/Histamine-releasing Factor via a Nonclassical Pathway ». Journal of Biological Chemistry 279, no 44 (19 août 2004) : 46104–12. http://dx.doi.org/10.1074/jbc.m404850200.
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Translationally controlled tumor protein (TCTP) is cytoplasmic and structurally related to guanine-nucleotide free chaperones. TCTP (also called histamine-releasing factor) has been described previously as a secreted protein that participates in inflammatory responses by promoting the release of histamine. How TCTP is eventually exported out of the cell to promote such activities is unknown. Here we show that TCTP secretion was insensitive to either brefeldin A or monensin, suggesting that it proceeds via an endoplasmic reticulum/Golgi-independent or nonclassical pathway. Moreover, our analyses also suggest that secreted TCTP originates from pre-existing pools. TSAP6, a p53-inducible 5–6 transmembrane protein, was found to interact with TCTP in a yeast two-hybrid hunt. GST pull down assays confirmed their direct interaction, and immunofluorescence analysis revealed their partial co-distribution to vesicular-like structures at the plasma membrane and around the nucleus. Functionally, the overexpression of TSAP6 consistently leads to enhanced secretion of both endogenously and exogenously expressed TCTP. Finally, we found TCTP in preparations of small secreted vesicles called exosomes, which have been suggested as a possible pathway for nonclassical secretion. Overexpression of TSAP6 also increased TCTP levels in exosome preparations. Altogether, these data identify a novel role for TSAP6 in the export of TCTP and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion.
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Sempéré, A. J., G. A. Bubenik et J. H. Smith. « Antler cycle and thermolabile and thermostable alkaline phosphatase in white-tailed deer ; circannual and circadian rhythms and variation after thyroxine, dexamethasone and ACTH administration ». Acta Endocrinologica 111, no 1 (janvier 1986) : 133–39. http://dx.doi.org/10.1530/acta.0.1110133.
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Abstract. The plasma levels of thermolabile (TLAP) and thermostable (TSAP) alkaline phosphatase were investigated in adult male white-tailed deer. Distinct seasonal variation of TLAP (with highly elevated levels in July) were observed, whereas TSAP exhibits low concentration with a small increase in October. No circadian rhythm was found for TLAP or TSAP. A close correlation (r = 0.98) between TLAP activity and antler weight was found. Administration of ACTH or dexamethasone were ineffective in influencing AP activity. On the other hand, variations of triiodothyronine (T3) levels in plasma induced by thyroxine (T4) injections correlated well with concentration of TLAP.
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Foo, Anne Mei Mei, et Helena Aman Hashim. « AN ANALYSIS OF THE SHOP HOUSES FAÇADE AND THE SPECIAL AREA PLAN OF TAIPING HERITAGE TOWN ». Built Environment Journal 15, no 2 (30 juillet 2018) : 39. http://dx.doi.org/10.24191/bej.v15i2.9707.
Texte intégralRésumé :
Heritage towns in many countries are facing the pressure of redevelopment due to economic needs and also in the name of tourism. It is unfortunate that many a times, the conservation process is separated from development planning cum redevelopment thus destroying the urban fabric. Taiping is one such town that has been identified to be developed for heritage tourism under the Special Area Plan development plan upon its declaration as a Heritage Town in 1999. The Taiping Special Area Plan (TSAP 2010) was launched in 2010 with seven development plans set within the Taiping Town and the Lake Gardens Conservation Zone. The objective of this study is to explore the level and type of change to the façade characteristics of buildings located within Taiping Town Conservation Zone (TTCZ) since the implementation of TSAP 2010 and the conformance of these buildings with change to the TSAP 2010 guidelines. The research adopted a case study strategy with a field survey of the entire building units located within TTCZ followed by a document review of the TSAP 2010 guideline. The TTCZ photo inventory was cross-analysed with archival data to firstly identify the level of change based on a numerical rating scale. The data for building units with change were then analysed further to identify the type of change followed by its adherence to the TSAP 2010 guidelines. The findings revealed that there were changes to the building’s façade characteristics even though the overall magnitude of change was low. The changes were found to be mainly on the shop house typology as opposed to other typologies and the shop houses with changes did not adhere to the TSAP 2010 guidelines. The study concluded that the façade characteristics of building units has changed prior to 2010 and the TSAP 2010 guidelines may have not been implemented fully though this may need to be studied further. Keywords: Special Area Plan (SAP), shop houses, façade characteristics, Taiping, conservation
Thèses sur le sujet "TSAPU"
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COROLLI, LUCA. « Deterministic and Stochastic Optimization For Heterogeneous Decision Phases In The Air Traffic Domain ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50551.
Texte intégralRésumé :
Scheduling is a complex activity that is needed in a large number of fields, which can involve heterogeneous factors and that may have different goals. In this thesis, scheduling problems that involve the air traffic field at different phases are faced. At each phase, the different characteristics of the problems are considered, devoting special attention to uncertainty. Given the heterogeneous characteristics and goals of the problems, different models and methods are proposed to solve each of them.
The first analyzed phase is the strategic phase. It takes place around six months before the operation of flights, when they need to be assigned scheduled departure and arrival times at the airports where they operate. Future capacity realizations are very difficult to forecast at this phase, as capacity is influenced by weather conditions. A two-stage stochastic programming model with two alternative formulations is proposed to capture this uncertainty. Since the number of scenarios may be extreme, Sample Average Approximation is used to solve the model. The utilization of the proposed model allows to identify advantageous tradeoffs between schedule/request discrepancies, i.e., the distance between the allocated schedule and airline requests, and operational delays. This tradeoff can result in substantial reductions of the cost of delays for airlines. In the computational experiments, delays were reduced up to 45% on an instance representing a network of European airports.
The second considered phase is the tactical phase, which takes place on the day of operation of flights. At this time, complete flight plans need to be defined, specifying the route and operation times of flights. This is done considering two different sources of uncertainty. First, uncertainty on capacity availability is taken into account, similarly to the strategic phase. However, the number of capacity realization scenarios is now small, as they can be defined using available weather forecasts. The problem of minimizing delay costs considering this source of uncertainty is the Stochastic Air Traffic Flow Management problem. A two-stage stochastic programming model with two alternative formulations is proposed to solve this problem. An ad-hoc heuristic that takes advantage of the good structure of the model is used to solve problem instances within short computation times. The analysis of the Value of the Stochastic Solution shows that the proposed stochastic model can significantly reduce delay costs when bad weather affects the whole network. Second, the implicit uncertainty on the departure time of flights is taken into account. This kind of uncertainty involves operations that may cause a delay on the scheduled departure time of a flight. The flexibility of the scheduled time of departure, as well as the other flight operations, is determined defining time windows within which flights are granted capacity resources to operate. The narrower a time window, the more critical a flight operation. The problem of minimizing delay cost and maximizing time windows is faced by the Air Traffic Flow Management Problem with Time Windows. The problem is formulated with two alternative deterministic models, one of which is able to provide time windows in 40" on average for instances involving over 6,000 flights. Less conservative criteria to reserve capacity within time windows can also be used. Despite not granting the possibility for a flight to execute its operations at every instant of a time window, the implementation of these alternative criteria is shown to be viable. In fact, less than 0.14% of flights were subject to capacity shortages in the analyzed cases.
Finally, the operational phase takes place when operations are being executed. The goal at this phase is to manage the final departure times announced by flights - with uncertain information becoming deterministic - allowing them to depart at the announced time even if this time exceeds the assigned departure time window. This problem is named Real Time Flight Rescheduling with Time Windows. Resources are provided to flights that need them by reallocating previously reserved capacity with an algorithm that follows the Ration-By-Schedule mechanism. Both the practical usage of time windows and the impact of collaboration among airlines are studied. While airline collaboration limits time window flexibility up to some time before the scheduled departure of a flight, it can allow to reduce additional flight delays by over 14%.
This thesis is a first work that involves determining flight schedules from the moment of their definition to the time of execution of flights. Providing cost reductions by considering the different factors that influence each decision phase can lead to a global improvement of the management of flight operations, whose delays are very expensive in practice for airlines.
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Lespagnol, Alexandra. « Réversion tumorale : étude fonctionnelle de TSAP6 et TCTP ». Phd thesis, Université Paris-Diderot - Paris VII, 2008. http://tel.archives-ouvertes.fr/tel-00294614.
Texte intégralRésumé :
Mon travail de doctorat a consisté en l'étude de deux gènes, TSAP6 et TCTP, qui sont régulés de manière différentielle dans la réversion tumorale. Les protéines encodées par ces deux gènes interagissent et forment un complexe tant in vitro que in vivo. Mon objectif était de mieux comprendre la fonction biologique de ces deux gènes. Différentes approches ont été employées, notamment la cristallographie (TCTP), souris knockout (TSAP6 et TCTP) et études par mutagénèse dirigée (TSAP6 et TCTP). Les souris knockout pour le gène tsap6 présentent une anémie microcytaire. Nous démontrons que cette anémie est due à un retard de maturation des réticulocytes ainsi qu'à une sécrétion défectueuse du récepteur à la Transferrine par les exosomes. Étant donné que le gène TSAP6 est une cible transcriptionnelle directe de la p53, nous avons voulu analyser la sécrétion des exosomes suite à une stimulation de p53 (par rayon X ou Actinomicine D). Nous montrons qu'en l'absence de TSAP6, on ne parvient pas à stimuler une sécrétion des exosomes. De manière plus générale ces expériences ont démontré que le gène TSAP6 avait in vivo un rôle prédominant dans la sécrétion des exosomes, y compris suite à l'activation de la p53.
Nous avons surtout étudié le rôle que joue TCTP dans l'apoptose. La délétion du gène tctp dans les souris knockout est létale en provoquant une augmentation de l'apoptose au cours de l'embryogenèse. Cette mort embryonnaire se produit entre les 6,5ème et 9,5ème jours du développement. La détermination de la structure de la protéine TCTP par cristallographie avec une résolution de 2A montre que la protéine humaine est très homologue à celle de s.pombe. De plus, nous avons observé suite à une analyse informatique une homologie de structure entre les hélices H2 et H3 de TCTP et les hélices H5 et H6 de BAX, une protéine pro-apoptotique impliquée dans la perméabilité de la membrane mitochondriale. On a démontré que grâce à ces deux hélices, TCTP effectue son action anti-apoptotique et inhibe la dimérisation de BAX à la membrane des mitochondries, empêchant ainsi l'apoptose.
Nous montrons également que la Sertraline et la Thioridazine, qui induisent la mort des cellules tumorales et une baisse concomitante de TCTP, se lient directement à TCTP et empêchent ainsi la formation du complexe TSAP6-TCTP.
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Lespagnol, Alexandra. « Reversion tumorale : étude fonctionnelle de TSAP6 et TCTP ». Paris 7, 2008. http://www.theses.fr/2008PA077033.
Texte intégralRésumé :
Mon travail de doctorat a consisté en l'étude de deux gènes, TSAP6 et TCTP, qui sont régulés de manière différentielle dans la réversion tumorale. Les protéines encodées par ces deux gènes interagissent et forment un complexe tant in vitro que in vivo. Mon objectif était de mieux comprendre la fonction biologique de ces deux gènes. Différentes approches ont été employées, notamment la cristallographie (TCTP), souris knockout (TSAP6 et TCTP) et études par mutagénèse dirigée (TSAP6 et TCTP). Les souris knockout pour le gène tsapô présentent une anémie microcytaire. Nous démontrons que cette anémie est due à un retard de maturation des réticulocytes ainsi qu'à une sécrétion défectueuse du récepteur à la Transferrine par les exosomes. Étant donné que le gène TSAP6 est une cible transcriptionnelle directe de la p53, nous avons voulu analyser la sécrétion des exosomes suite à une stimulation de p53 (par rayon X ou Actinomicine D). Nous montrons qu'en l'absence de TSAP6, on ne parvient pas à stimuler une sécrétion des exosomes. De manière plus générale ces expériences ont démontré que le gène TSAP6 avait in vivo un rôle prédominant dans la sécrétion des exosomes, y compris suite à l'activation de la p53. Nous avons surtout étudié le rôle que joue TCTP dans l'apoptose. La délétion du gène tctp dans les souris knockout est létale en provoquant une augmentation de l'apoptose au cours de l'embryogenèse. Cette mort embryonnaire se produit entre les 6,5ème et 9,5eme jours du développement. La détermination de la structure de la protéine TCTP par cristallographie avec une résolution de 2A montre que la protéine humaine est très homologue à celle de s. Pombe. De plus, nous avons observé suite à une analyse informatique une homologie de structure entre les hélices H2 et H3 de TCTP et les hélices H5 et H6 de BAX, une protéine pro-apoptotique impliquée dans la perméabilité de la membrane mitochondriale. On a démontré que grâce à ces deux hélices, TCTP effectue son action anti-apoptotique et inhibe la dimérisation de BAX à la membrane des mitochondries, empêchant ainsi l'apoptose. Nous montrons également que la Sertraline et la Thioridazine, qui induisent la mort des cellules tumorales et une baisse concomitante de TCTP, se lient directement à TCTP et empêchent ainsi la formation du complexe TSAP6-TCTPMy work consisted in a functional study of two genes TSAP6 and TCTP regulated during the process of the tumoral reversion in knockout mice in order to understand their roles during the reversion process. TSAP6-deficient mice display a microcytic anemia due to a defect of the turn-over of Transferrin-Receptor by exosomes in reticulocytes. In these animals, the response to stimulation of apoptosis is also compromised and accompanied by a defect of exosome secretion. The deletion of the lpt1 gene in knockout mice is lethal. The loss of TCTP causes an increase of apoptosis during embryogenesis leading to the death of the embryo between the 6,5 and 9,5th day of the development. The crystal structure of human TCTP revealed a homology between helices H2 and H3 of TCTP and helices H5 and H6 of BAX a proapoptotic protein involved in mitochondrial membrane permeability. We demonstrated that these two helices are responsible for the antiapoptotic function of TCTP and inhibit the dimerization of BAX in the mitochondrial membrane preventing cell death. We also show that Sertraline and Thioridazine which kill cancer cells and decrease TCTP in cells, bind to TCTP and prevent the formation of the TSAP6-TCTP complex. They increase the TSAP6 level and activate TCTP secretion by a pathway independent of exosomes. These results shed light on the function of these two proteins during the process of tumoral reversion
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Vosloo, Frances Antoinette. « Antjie Krog se vertaling die sterre sê ‘tsau’ : ’n deskriptiewe analise ». Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/2271.
Texte intégralRésumé :
Thesis (MPhil (Afrikaans and Dutch))—University of Stellenbosch, 2005.In this thesis the translating strategies of domestication and foreignisation in Antjie Krog’s anthology die sterre sê ‘tsau’ (2004) are investigated. A descriptive approach is followed in the analysis, with the main focus on Descriptive Translation Studies (DTS) and the poststructuralist concept différance (Derrida 1982). The researcher states that Krog, in her translation of the /Xam narratives, 1) follows a foreignising strategy by moving the target reader towards the source text; 2) is visible as translator as a result of her use of annotations, for example; and 3) that, in addition to foreignisation, she moves the source text towards the target reader by domesticating towards her own poetic style. The introductory chapter is followed by a discussion of those translational models relevant to the analysis. The discussion focuses on Venuti’s (1995) model of domestication/ foreignisation, as well as on some aspects of deconstruction and différance. Lambert and Van Gorp’s (1985) descriptive model is expounded as the primary model for the analysis of the anthology. The following chapter involves a literary historic overview of the language and culture of the /Xam in order to fully contextualise both the source and target texts. In the following chapter the most relevant aspects of Krog’s poetics and translational strategy are discussed as far as they coincide with the main argument of the thesis. In the practical part of the thesis five poems from the anthology are discussed on macro-, micro- and systemic level in order to establish Krog’s translational strategy as well as the presence in the translation of her poetic style. In the final chapter the extent to which the findings in the analysis correspond to the hypothesis is concluded.
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Beaucourt, Séverine. « Etude de 2 gènes cibles de la protéine P53 : siah (seven in absentia human homologue) et tsap6 (tumor suppressor activated pathway 6) ». Phd thesis, Université Paris Sud - Paris XI, 2005. http://tel.archives-ouvertes.fr/tel-00157749.
Texte intégralRésumé :
Notre travail a consisté à étudier 2 gènes impliqués dans la réversion tumorale et régulés par P53.Nous avons identifié dans le promoteur du gène siah-1b une séquence sur laquelle P53 se lie in vitro et in vivo. De plus, nous avons montré la fonctionnalité de cet élément de réponse suite à l'induction de P53.
La particularité de ce site, dont la structure diffère fortement du consensus de liaison de P53 à l'ADN, ouvre de nouvelles perspectives dans l'analyse des mécanismes régulés par P53.
L'étude de la protéine TSAP6 murine a permis de caractériser son expression au niveau tissulaire et intracellulaire. La fonction de TSAP6 n'étant pas bien connue, nous avons entrepris de l'analyser dans des modèles animaux portant un gène tsap6 muté ou invalidé.
La mutation du gène tsap6 Gln-395-Lys induit l'apparition d'une microcytose et d'un emphysème pulmonaire chez la souris. La caractérisation des mécanismes conduisant à ces phénotypes est en cours et nous permettra de mieux comprendre la fonction de TSAP6.
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Duflaut, Dominique. « Etudes moléculaires et fonctionnelles des gènes TSAP6 (Tumor Suppressor Activated Pathway 6) et TCTP (Translationally Controlled Tumor Protein) : cibles pharmacologiques anti-tumorales ». Phd thesis, Université Paris Sud - Paris XI, 2008. http://tel.archives-ouvertes.fr/tel-00293914.
Texte intégralRésumé :
L'objectif de mon travail de doctorat était une caractérisation fonctionnelle des gènes TCTP et TSAP6. Ces gènes sont impliqués dans la réversion tumorale et forment un complexe protéique. Tpt1, codant pour la protéine TCTP, est le gène le plus sous-exprimé lors de la réversion tumorale. L'analyse du cristal de TCTP humain montre une forte homologie entre ses hélices H2-H3 et les hélices H5-H6 de Bax. Grâce à ses hélices, TCTP inhibe l'apoptose induite par Bax au niveau des mitochondries. En effet, nous démontrons que TCTP, entre autres par le biais de ces hélices, empêche la dimérisation de Bax.
Nous avons aussi développé une lignée de souris TCTP knockout qui présentent une létalité embryonnaire précoce.
En parallèle, nous avons étudié TSAP6, qui encode pour une protéine à 6 domaines transmembranaires et qui est une cible transcriptionnelle directe de la p53. Nous avons établi une lignée murine TSAP6 knockout présentant une anémie microcytaire avec une splénomégalie. Les réticulocytes issus des souris knockout présentent un retard de maturation et une anomalie de sécrétion du Récepteur à la Transferrine par les exosomes. De manière plus générale, les résultats obtenus montrent, in vivo, que TSAP6 contrôle la sécrétion des exosomes induite par activation de la P53. Nous montrons aussi que la Sertraline et la Thioridazine empêchent la formation du complexe TSAP6-TCTP.
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Hoffsaes, Colette. « Les systemes d'information dans le domaine medical : mediation entre connaissance et action ? » Paris 7, 1986. http://www.theses.fr/1986PA070043.
Texte intégralRésumé :
Les enjeux du projet de societe de la communication sont recherches par l'observation de l'implantation de systemes d'information, dans lesquels se concretise la volonte de resoudre des problemes grace a une meilleure information. Le domaine choisi est la medecine. Trois grands buts sont vises par les concepteurs : developper une optique de sante publique, retablir des liens entre les medecines hospitaliere et ambulatoire, ameliorer la formation des praticiens. Sont etudies : g. A. M. I. N. (gestion automatisee de medecine infantile) du ministere de la sante, les tableaux statistiques d'activite des praticiens de la securite sociale et plusieurs systemes scientifiques lies a la pratique medicale. Tous ces systemes echouent largement a realiser leurs objectifs. Sont analysees les explications couramment avancees par les concepteurs. Les progres techniques ne paraissent pas repondre aux objections fondamentales. La resistance des praticiens a la bureaucratisation et a la technocratisation qui se manifeste a l'encontre des systemes d'information n'explique pas vraiment leur desaffection. Les echecs sont imputables a l'illusion informationnelle qui sous-tend le modele des systemes : rassemblement-traitement-diffusion. On rassemble pour connaitre, mais on sous-estime les difficultes de la formalisation et les systemes revelent les incertitudes epistemologiques d'une visee positiviste. On diffuse pour transmettre un savoir, mais seuls les praticiens savants peuvent profiter de donnees fragmentees dont la pertinence est discutee. Le contexte historique et social, ignore, confere aux donnees un sens mal maitrise. L'auteur conclut que les concepteurs conscients de l'efficacite technique limitee de leurs systemes recherchent un impact symbolique, prouvant l'excellence de leur demarche informationnelle. Mais il craint la pression reductrice de la rationalite operatoire si le verrou humaniste tombe, comme le souhaiteraient de nombreux concepteurs. Il parait urgent de fonder cette demarche sur un modele de l'homo communicans tel celui que propose f. Jacques.
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Scarlato, Michele. « Sicurezza di rete, analisi del traffico e monitoraggio ». Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3223/.
Texte intégralRésumé :
Il lavoro è stato suddiviso in tre macro-aree.
Una prima riguardante un'analisi teorica di come funzionano le intrusioni, di quali software vengono utilizzati per compierle, e di come proteggersi (usando i dispositivi che in termine generico si possono riconoscere come i firewall).
Una seconda macro-area che analizza un'intrusione avvenuta dall'esterno verso dei server sensibili di una rete LAN.
Questa analisi viene condotta sui file catturati dalle due interfacce di rete configurate in modalità promiscua su una sonda presente nella LAN.
Le interfacce sono due per potersi interfacciare a due segmenti di LAN aventi due maschere
di sotto-rete differenti. L'attacco viene analizzato mediante vari software.
Si può infatti definire una terza parte del lavoro, la parte dove vengono analizzati i file
catturati dalle due interfacce con i software che prima si occupano di analizzare i dati di
contenuto completo, come Wireshark, poi dei software che si occupano di analizzare i dati di
sessione che sono stati trattati con Argus, e infine i dati di tipo statistico che sono stati trattati
con Ntop.
Il penultimo capitolo, quello prima delle conclusioni, invece tratta l'installazione di Nagios, e
la sua configurazione per il monitoraggio attraverso plugin dello spazio di disco rimanente su
una macchina agent remota, e sui servizi MySql e DNS. Ovviamente Nagios può essere
configurato per monitorare ogni tipo di servizio offerto sulla rete.
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cheng, Chen jyh, et 陳志聲. « Research on Calligraphy of Wei-Chu Tsau ». Thesis, 2010. http://ndltd.ncl.edu.tw/handle/72874281089576473978.
Texte intégralRésumé :
碩士明道大學
國學研究所
98
Mr. Cao Wei-Chu was the researcher’s principal in National Cingshuei Senior High School. A leading educator with notable values and aspirations, Cao dedicated himself to motivate students and encourage the young. Since his youth, he had been nurtured with Chinese calligraphy and painting. In the company of his artistic talents, Cao was highly regarded as a pastoral painter and a lyric painter of Chinese ink and wash painting in the art world. Principal Cao guided teachers and students through art education in the school. He shaped students’ ethics and influenced those taking interest in calligraphy and painting, as myself, with his lifetime pursuit of arts. Nowadays many accomplished mid-generation artists are alumni of National Cingshuei Senior High School. I conclude it is all creditable to Principal Cao for his impetus of art education then. After graduating from Department of Business Administration, National Chung Hsing University, I began to pursue public office. During my decade-long service as Director-general of Taichung County Cultural Affairs Bureau, I have continually promoted various art and cultural activities, endeavoring to inspire public through cultural development and improve general social conduct. A great part of it owes to Principal Cao’s bearing and influence. The principal has left us nearly for thirty years; his doctrines have yet to fade. However, I’ve growing further apart from relevant intellectuals over years. Among the educational or the cultural community, esteemed seniors in connection with Principal Cao have been gradually declining. It is increasingly difficult to gather firsthand information from field study interviews. The remaining are few disciples, such as I, who feel compelled to glorify and preserve the precursors’ effort and works. In recent years, I have been committed to collect and organize the principal’s calligraphies, paintings and artifact records during his lifetime. Based on the existing documents, I have conducted a research of, and re-presented the world with, the artistic achievements of Cao Wei-Chu, an artist as well as an educator. Cao Wei-Chu aficionados can indulge in his pastoral landscapes and lyric style. As for individuals who are aware of preserving contemporary Chinese culture, this ought to be a research subject with profound significance. Certainly, Principal Cao not only attained in Chinese ink and wash painting, but also in calligraphy. His private tutor Cao Bei-Hai (courtesy name Xi-I), an erudite scholar in Qing Dynasty, was a well-recognized calligrapher who studied calligraphy in depth. Benefiting from the exceptional teaching of Mr. Xi-I, Mr. Wei-Chu progressed considerably in writing and calligraphy within a year, and also built up a solid foundation of brush and ink painting. Cao strived to study calligraphy, and became proficient at standard, cursive, clerical and seal script styles, especially at seal and clerical scripts. Even at an old age, before he passed, he still exercised unrelentingly through copying models of calligraphy. Although he modestly claimed that painting was simple whilst calligraphy was difficult; and he was unable to develop a style of his own yet with a lifetime of practice. From his published works, nevertheless, we can witness his righteous passion and sense of mission for advocating calligraphy education. He exhibited expertise throughout calligraphy theories, overviews of calligraphy styles and descriptions of the Han dynasty steles. From his calligraphy-related works, one can find demonstrations along side with textual research and explanation essays, which showcase Principal Cao’s extensive comprehension in the associated fields. As a calligraphy enthusiast, I’m driven to explore it further. Therefore I forgo the aspect of Cao as a renowned Chinese painter and his paintings. This research dissertation is centered on what I have learned in Art of Calligraphy Section, Institute of Chinese Studies in Mingdao University, the very related phenomenon of Cao Wei-Chu’s calligraphy. Valuable opinions and suggestions from professors and precursors are awaited with anticipation
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Santos, Rafael Benjamin dos. « Análise do TSAP E GPAI em Acções Técnicas e Tácticas do Basquetebol ». Doctoral thesis, 2018. http://hdl.handle.net/10316/83620.
Texte intégralRésumé :
Tese de Doutoramento em Ciências do Desporto, Ramo de Treino Desportivo, apresentada à Faculdade de Ciências do Desporto e Educação Física da Universidade de CoimbraObjectivo: Este estudo teve como objectivo principal analisar o TSAP e o GPAI na avaliação do desempenho técnico e táctico do jogo de basquetebol. Metodologia: A amostra foi constituída por 20 (n=20) jogadores profissionais da selecção masculina de Basquetebol Norte Americana, com idades compreendidas entre os 23 e 32 anos, apresentando os atletas mais de 10 anos de experiência na prática do basquetebol. Para medir os efeitos dos indicadores e variáveis do GPAI e do TSAP, analisámos 17 jogos (9 jogos do Campeonato Mundial de Basquetebol de 2014, realizado em Espanha, bem como, também, 8 jogos dos Jogos Olímpicos de 2016, que teve lugar no Rio de Janeiro). Suportados nos estudos de Gréhaigne et al. (1997) e Nadeau et al. (2008), os indicadores do TSAP permitiram calcular o índice de eficiência dos jogadores envolvidos e o volume de jogo. Com base em Oslin et al. (1998) e Nadeau et al. (2008), na análise do GPAI, calculámos a tomada de decisão do jogador, execução técnica e apoio apropriado à equipa. Tendo como referência o estudo de Nadeau et al. (2008), foi aplicada estatística descritiva (percentagem, média e desviopadrão) para todas as variáveis do TSAP e GPAI. De modo a avaliarmos a prestação da equipa em diferentes competições (e.g., campeonato do mundo e jogos olímpicos), recorreu-se ao teste estatístico t Student para amostras independentes (independente-sample t test). Para a consequente aplicação deste teste, os pressupostos da distribuição normal das variáveis nos diferentes grupos foram avaliados através do teste de Shapiro-Wilk e a homogeneidade ponderada através do teste de Levene (Pallant, 2011). Finalmente, para medirmos a relação entre as variáveis em estudo, foi utilizado o coeficiente de correlação de Pearson, com um nível de significância de 0,05 (Pallant, 2011). Os dados foram tratados no programa IBM SPSS Statistics (versão 21.0, Chicago IL). Resultados: Os resultados indicaram que a análise das variáveis do GPAI, sobretudo: “Decisão Apropriada” (DA) e “Apoio apropriado” (AA) foram as acções que mais ocorreram durante os jogos analisados. Por seu lado, para o instrumento de análise TSAP, constata-se que as variáveis: “Bola Neutra” (BN) e “Conquista de Bola” (CB) foram as acções que emergiram com maior frequência. Os resultados do presente estudo indicaram ainda que instrumentos como o GPAI permitem analisar o resultado final da acção e as variáveis de processo de execução motora relacionadas com as acções de jogo, verificando-se, neste sentido, diferenças estatisticamente significativas nas seguintes variáveis: TSAP – Receção de Bola (p-value=,002 ≤0,05, t=-3,784, df=15,000); TSAP – Bola Neutra (pvalue=,006 ≤0,05, t=-3,221, df=15,000), TSAP – Bola Ofensiva (p-value=,000 ≤0,05, t=-6,163, df=15,000). Conclusões: Conclui-se que o GPAI foi robusto para medir o comportamento da performance de jogo relativo ao conhecimento e habilidade do atleta na resolução de problemas tácticos. Considerando as evidências estatísticas, existe uma tendência de maior robustez deste instrumento na análise de movimentos associados ao basquetebol. Por seu lado, o TSAP foi eficaz na avaliação da frequência dos vários acontecimentos técnicos e tácticos que emergiram no jogo, mostrando-se confiável para determinar o nível de desempenho motor dos jogadores. Porém, também apresentou algumas limitações para medir a tomada de decisão do jogador. Em harmonia, TSAP e GPAI, permitem identificar as características da própria equipa e da equipa adversária, aperfeiçoando e elaborando programas de preparação e treino apropriados à natureza da competição, tendo aplicações práticas na deteção de padrões de competição e no contexto em que a mesma ocorre (e.g., faixa etária, tipo e nível de campeonato, interclubes ou interseleções, etc.). Objective: The main objective of this study was to analyze two different instruments in the evaluation of the technical and tactical performance of the basketball game, namely, TSAP and GPAI. Methodology: The sample consisted of 20 (n = 20) professional p layers from the North American Men's Basketball Selection, aged 23 to 32, with athletes more than 10 years of experience in basketball practice. In order to measure the effects of the indicators and variables of the GPAI and TSAP, we analyzed 17 games (9 m atches of the 2014 World Basketball Championship held in Spain, as well as 8 matches of the 2016 Olympic Games, which took place in Rio from January). Supported by Gréhaigne et al. (1997) and Nadeau et al. (2008), the TSAP indicators allowed to calculate t he efficiency index of the players involved and the volume of game. Based on Oslin et al. (1998) and Nadeau et al. (2008), in the analysis of the GPAI, we calculated the player's decision making, technical execution and appropriate support to the team. Bas ed on the study by Nadeau et al. (2008), descriptive statistics (percentage, mean, and standard deviation) were applied to all TSAP and GPAI variables. In order to evaluate the performance of the team in different competitions (e.g., world championship and olympic games), we used the Student t test for independent samples (independent - sample t test). For the subsequent application of this test, the assumptions of the normal distribution of the variables in the different groups were evaluated using the Shapi ro - Wilk test and the homogeneity weighted by the Levene test (Pallant, 2011). Finally, to measure the relationship between the variables under study, Pearson's correlation coefficient was used, with a significance level of 0.05 (Pallant, 2011). The data we re treated in the IBM SPSS Statistics program (version 21.0, Chicago IL). Results: The results indicate that the analysis of the GPAI variables, especially: "Appropriate Decision" (AD) and "Appropriate Support" (AA) were the actions that occurred most dur ing the analyzed games. On the other hand, for the TSAP analysis instrument, the variables "Neutral Ball" (BN) and "Conquest of Ball" (CB) were the most frequently emerged. The results of the present study also indicate that instruments such as the GPAI al low us to analyze the final outcome of the action and the variables of the motor execution process related to the game actions, in order to verify statistically significant differences in the following variables: TSAP - Ball Receipt (p - value =, 002 ≤0.05, t = - 3.784, df = 15,000); TSAP - Neutral Ball (p - value =, 006 ≤0.05, t = - 3.222, df = 15,000), TSAP - Offensive Ball (p - value =, 000 ≤0.05, t = - 6,163, df = 15,000 ). Conclusions: It is concluded that the GPAI was robust to measure the behavior of game pe rformance related to the athlete's knowledge and ability to solve tactical problems. Considering the statistical evidence, there is a trend of greater robustness of this instrument in the analysis of movements associated with basketball. For its part, the TSAP was effective in assessing the frequency of various technical and tactical events that emerged in the game, proving to be reliable in determining the level of motor performance of the players. However, it also presented some limitations to measure the player's decision making. In harmony, TSAP and GPAI allow to identify the characteristics of the team and of the opposing team, improving and elaborating programs of preparation and training appropriate to the nature of the competition, having practical a pplications in the detection of competition patterns and in the context in which it occurs (e.g., age group, type and level of championship, interclubs or interselections, etc.).
Livres sur le sujet "TSAPU"
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Schneersohn, Menaḥem Mendel. Be-ʻinyan nokhrim she-tsaru ʻal ʻayerot Yiśraʼel. [Brooklyn, N.Y ? : Maʻarekhet "Ḳol Yaʻaḳov", 2002.
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Schneersohn, Menaḥem Mendel. Be-ʻinyan nokhrim she-tsaru ʻal ʻayerot Yiśraʼel. [Brooklyn, N.Y ? : Maʻarekhet "Ḳol Yaʻaḳov", 2002.
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Wong, James Kim Min, Dato, 1922-, dir. No joke, James : The world according to William Wong Tsap En. Singapore : Summer Times Pub., 1985.
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Katsouros, Phlōros. Sentonia skepseōn kai astraphtera tsaph tsouph : Me aphormē to vivlio tou Dēmētrē Nolla Apo tē mia eikona stēn allē. Athēna : Koinōnia tōn (de)katōn, 2016.
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Krog, Antjie. Sterre Se 'Tsau'. Kwela Books, 2004.
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Aryadeva's Four Hundred Stanzas on the Middle Way : With Commentary by Gyel-tsap. Snow Lion Publications, 2008.
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Sonam, Ruth. Yogic Deeds of Bodhisattvas : Gyel-tsap on Aryadeva's Four Hundred (Textual Studies and Translations in Indo-Tibetan Buddhism). Snow Lion Publications, 1994.
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Sonam, Ruth. Yogic Deeds of Bodhisattvas : Gyel-tsap on Aryadeva's Four Hundred (Textual Studies and Translations in Indo-Tibetan Buddhism). Snow Lion Publications, 1994.
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The Stars Say 'Tsau' : /Xam Poetry of Dia!kwain, Kweiten-ta-//ken, /A!kunta, Han#kass'o, and //Kabbo. Kwela Books, 2004.
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Yunhwa Rao, Nancy. Two Theaters and a Merger in New York. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252040566.003.0012.
Texte intégralRésumé :
This chapter documents the rise of Cantonese opera theater in New York City from the mid-nineteenth century through the 1920s. By the mid-1920s, the New York theaters became a nodal point of the performing network linking San Francisco, Los Angeles, and elsewhere, sharing many of its talented performers. In New York's Chinatown, opera was an art form that united spectacle, drama, local and visiting talents, regional musical tastes, and musical tradition into a vibrant whole. At the height of its golden age, Chinese theater had taken its place in a city with a long and prestigious tradition in the theatrical and performing arts. Two theaters were established during this period: Jock Ming On and Lok Tin Tsau. The former arrived New York City from Vancouver, while the latter via Toronto and Boston. In 1927, the two merged to form Yong Ni Shang Theater. Many performers discussed in previous chapters reappear in this chapter. In addition, the chapter discusses the relation between Peking opera star, Mei Lanfang’s US tour and Chinatown theaters. Finally, through a close analysis of the phonograph record advertisement, the chapter reflects on the connection of Cantonese opera and the community.
Chapitres de livres sur le sujet "TSAPU"
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« Ta tsau Formation ». Dans Geological Formation Names of China (1866–2000), 1093. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-93824-8_7742.
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« (6113) Tsap [2.65, 0.20, 2.2] ». Dans Dictionary of Minor Planet Names, 28. Berlin, Heidelberg : Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/978-3-540-34361-5_133.
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Gazizov, Timur, Tatyana Prishepa et Mikhail Chervonnyy. « Development and Support of E-Learning Systems in Tomsk State Pedagogical University ». Dans Handbook of Research on Estimation and Control Techniques in E-Learning Systems, 350–64. IGI Global, 2016. http://dx.doi.org/10.4018/978-1-4666-9489-7.ch025.
Texte intégralRésumé :
Processes of IT development in modern society and closely related processes of IT development in all forms of educational activities are characterized by the process of improvement and mass distribution of up-to-date information and communication technologies (ICT). Similar technologies are used extensively for communication and collaboration between the teacher and the student in modern open and distance learning. A modern teacher must not only have knowledge of ICT but also must be an expert on their application in his/her professional activity. In this case, application of such technology is closely related to distance learning and e-learning. In this paper, we intend to simulate and show outcomes of the development of e-learning support systems on the example of Tomsk State Pedagogical University (TSPU).
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Syanova, Elena I. « The words denoting a male domestic goat in Voronezh dialects (koz’ol, tsap, iman) ». Dans Lexical atlas of Russian folk dialects (Materials and research), 748–60. Institute for linguistic Studies Russian Academy of Sciences, 2020. http://dx.doi.org/10.30842/26586150202008.
Texte intégralActes de conférences sur le sujet "TSAPU"
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Xue, Diwen, Benjamin Mixon-Baca, ValdikSS, Anna Ablove, Beau Kujath, Jedidiah R. Crandall et Roya Ensafi. « TSPU ». Dans IMC '22 : ACM Internet Measurement Conference. New York, NY, USA : ACM, 2022. http://dx.doi.org/10.1145/3517745.3561461.
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Ramanathan, Chandrashekar, et Apurva Kulkarni. « TSAPI : Enhancing Existing OLTP Databases with Temporal Query Capabilities for Analytics ». Dans CODS-COMAD 2023 : 6th Joint International Conference on Data Science & Management of Data (10th ACM IKDD CODS and 28th COMAD). New York, NY, USA : ACM, 2023. http://dx.doi.org/10.1145/3570991.3571069.
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Ban, Maja, Tomislav Đurković et Nenad Marelić. « Comparison of FMS tests between female and male volleyball players with possible implications on volleyball performance ». Dans 12th International Conference on Kinanthropology. Brno : Masaryk University Press, 2020. http://dx.doi.org/10.5817/cz.muni.p210-9631-2020-1.
Texte intégralRésumé :
Purpose: The main goal of this study is to determine possible differences in the range and quality of movement between senior male and female volleyball players of HAOK Mladost. Methods: Respondents, all right-handed and healthy, were members of the senior volleyball team of HAOK Mladost (female n=24, male n=17). The testing was conducted during the transition period, between the first and second competition period. We used seven tests, all part of standard FMS protocol: Deep Squat (DS), Hurdle Step (HS), In-Line Lunge (ILL), Shoulder Mobility (SM), Active Straight Leg Raise (ASLR), Trunk Stability Push-up (TSPU), Rotary Stability (RS), with 12 measured variables (left and right side for five bilateral tests plus DS and TSPU). Educated staff at the Faculty of Kinesiology, University of Zagreb con-ducted the testing. The examination of significance of the differences between senior male and female volleyball players was conducted by using the nonparametric Mann-Whitney U test. Results: Statistical analysis showed significant difference in three tests: In – Line Lunge Left (ILLL), z= -2,11, p=0,03, with moderate effect size (r=0.33), Active Straight Leg Raise Left (ASLRL), z= -2,58, p=0,01, with moderate to strong effect size (r=0.4) and Stability Push-up (TSPU) z= -3,68, p=0,00, with strong effect size (r=0.58). Conclusion: Statistically significant difference was determined in the range and quality of movement in three measured variables. Male volleyball players achieved better results in two tests: In-Line Lunge Left (ILLL) and Stability Push-up (TSPU). That addresses to a higher ability to keep the balance during lunges (reaction on short balls during reception or defence phase of the game) and considerably higher ability to maintain the stability of the trunk in the transfer of force from the upper extremities to the lower (during block) and vice versa (during spike). It is interesting to note that female volleyball players achieved a significantly better rating in the Active Straight Leg Raise Left (ASLRL) test, suggesting a better flexibility of the left hamstrings and better right hip mobility which enables higher capacity in performing el-ements which require extension, which include almost all volleyball elements (hitting, serve receive and transition into offense, defence and transition into counterattack and blocking, smashing and jump serve).
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Shapovalova, Tatiana, et Andriana Paslavska. « Involvement of combatant in professional creative activity as a factor of his social adaptation ». Dans SOCIOLOGY – SOCIAL WORK AND SOCIAL WELFARE – REGULATION OF SOCIAL PROBLEMS. NDSAN (MFC - coordinator of the NDSAN), 2020. http://dx.doi.org/10.32437/sswswproceedings-2020.tsap.
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Wang, Liyan, Kun Zhong et Ya Liu. « Enlightenment of Early Translation of Pen Tsau Kang Mu on the International Dissemination of TCM (Traditional Chinese Medicine) Treatment Protocols ». Dans 7th International Conference on Education, Language, Art and Inter-cultural Communication (ICELAIC 2020). Paris, France : Atlantis Press, 2020. http://dx.doi.org/10.2991/assehr.k.201215.378.
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Sarala, R., B. Sutharson et D. Jaya Kanth. « Thermal Elastic-Plastic Stress Analysis of Structural Elements With Creep ». Dans ASME 2005 Pressure Vessels and Piping Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/pvp2005-71061.
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Finite element analysis of thermo-mechanical problems is reported here. From the literature, it may be seen that the thermal-elastic plastic analysis of structural elements has continued to remain a research topic for a couple of decades. No one computationally verified the thermal elastic plastic stress analysis with creep using triangular elements or quadrilateral elements. Finite element analysis code TSAP (Thermal Structural Analysis Programme) was developed in FORTRAN to handle the elastic-plastic stress analysis on two-dimensional planar or three dimensional axisymmetry structures subjected to combined thermal and mechanical loads. In this work, thermo elastic plastic analysis is extended to creep support. A triangular or quadrilateral element has been used to analysis of structures with inclusion of creep. The formulation is based on isotropic or kinematic hardening rule. The validation checks on the program are carried out using results available in the literature. The parameters are considered while analyses are (1.) Type of materials used (2.) Type of elements used (3.) Structure geometry (axisymmetry, plane stress or plane strain) (3.) Type of analysis (steady state or transient state) (4.) Type of loading (5.) Various boundary conditions (conductive or heat flux boundary) (6.) Effect of creep inclusion.
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Bouhairie, Salem. « Analysis of Swirl Flow by Tube Inserts for CFD Study ». Dans ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52820.
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The petroleum and petrochemical industries continually seek mechanical methods to improve heat transfer in shell-and-tube heat exchangers. Tube bundle inserts are popular mechanical devices that help improve performance. The increase in the tubeside heat transfer coefficient by the insert allows for a decrease in required shellside flow length, assuming single tube pass. The flow length reduction allows for designing higher velocities and subsequent shellside shear rates, to help reduce crude oil fouling potential. This work presents some of HTRI’s ongoing experimental measurements and preliminary Computational Fluid Dynamics (CFD) simulations. CFD visualization of swirl flow dynamics and heat transfer inside the augmented tube provides insight on complex flow physics, which is misunderstood. Heat Transfer Research, Inc. (HTRI) collected experimental data for in-tube single-phase flow using twisted tape inserts in the Tubeside Single-Phase Unit (TSPU) situated in the Research and Technology Center (RTC). Our data will be used to calibrate ANSYS FLUENT CFD simulations of a tube with a twisted tape swirl insert. We first performed plain tube simulations and compared the heat transfer results with open literature measurements, for validation. We will modify the CFD tube model to have a swirl flow insert, and compare numerical results against open literature experimental data of diabatic single-phase swirl flow. In future, we will compute heat transfer (heating and cooling) and pressure drop for tube insert configurations at laminar and turbulent Reynolds numbers from 3000 to 500000. The range of tubeside Reynolds numbers required the use of the laminar, transition, and Realizable k-epsilon turbulence models with scalable wall functions. This study describes some of the mechanisms behind turbulent swirl flow augmentation inside a tube, as well as the limitations of conventional in-tube heat transfer correlations applied to swirl flow inserts.
Rapports d'organisations sur le sujet "TSAPU"
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Ralston, G. L. Test plan for : TSAP bit qualification : Temperature criteria. Office of Scientific and Technical Information (OSTI), octobre 1995. http://dx.doi.org/10.2172/414095.
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Outka, D. E. User's manual for the Trajectory Simulation and Analysis Program (TSAP). Office of Scientific and Technical Information (OSTI), mars 1989. http://dx.doi.org/10.2172/6140020.
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