Bibliographies thématiques / Trojan Nano Horse

Littérature scientifique sur le sujet « Trojan Nano Horse »

Auteur : Grafiati
Publié le 14 mars 2023

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Articles de revues sur le sujet "Trojan Nano Horse"

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Li, Zhibin, Xue-Feng Yu et Paul K. Chu. « Recent advances in cell-mediated nanomaterial delivery systems for photothermal therapy ». Journal of Materials Chemistry B 6, no 9 (2018) : 1296–311. http://dx.doi.org/10.1039/c7tb03166a.

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Luo, Zhuanxi, Zhenhong Wang et Baoshan Xing. « Insights into the uptake, distribution, and efflux of arsenite associated with nano-TiO2 in determining its toxicity on Daphnia magna ». Environmental Science : Nano 7, no 4 (2020) : 1194–204. http://dx.doi.org/10.1039/c9en01453e.

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Li, Yin, Rongyuan Zhang, Qing Wan, Rong Hu, Yao Ma, Zhiming Wang, Jianquan Hou, Weijie Zhang et Ben Zhong Tang. « Trojan Horse‐Like Nano‐AIE Aggregates Based on Homologous Targeting Strategy and Their Photodynamic Therapy in Anticancer Application ». Advanced Science 8, no 23 (20 octobre 2021) : 2102561. http://dx.doi.org/10.1002/advs.202102561.

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Witika, Bwalya A., Pedzisai A. Makoni, Larry L. Mweetwa, Pascal V. Ntemi, Melissa T. R. Chikukwa, Scott K. Matafwali, Chiluba Mwila, Steward Mudenda, Jonathan Katandula et Roderick B. Walker. « Nano-Biomimetic Drug Delivery Vehicles : Potential Approaches for COVID-19 Treatment ». Molecules 25, no 24 (16 décembre 2020) : 5952. http://dx.doi.org/10.3390/molecules25245952.

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The current COVID-19 pandemic has tested the resolve of the global community with more than 35 million infections worldwide and numbers increasing with no cure or vaccine available to date. Nanomedicines have an advantage of providing enhanced permeability and retention and have been extensively studied as targeted drug delivery strategies for the treatment of different disease. The role of monocytes, erythrocytes, thrombocytes, and macrophages in diseases, including infectious and inflammatory diseases, cancer, and atherosclerosis, are better understood and have resulted in improved strategies for targeting and in some instances mimicking these cell types to improve therapeutic outcomes. Consequently, these primary cell types can be exploited for the purposes of serving as a “Trojan horse” for targeted delivery to identified organs and sites of inflammation. State of the art and potential utilization of nanocarriers such as nanospheres/nanocapsules, nanocrystals, liposomes, solid lipid nanoparticles/nano-structured lipid carriers, dendrimers, and nanosponges for biomimicry and/or targeted delivery of bioactives to cells are reported herein and their potential use in the treatment of COVID-19 infections discussed. Physicochemical properties, viz., hydrophilicity, particle shape, surface charge, composition, concentration, the use of different target-specific ligands on the surface of carriers, and the impact on carrier efficacy and specificity are also discussed.
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Liu, Yang, Aftab Nadeem, Sujeesh Sebastian, Martin A. Olsson, Sun N. Wai, Emelie Styring, Jacob Engellau et al. « Bone mineral : A trojan horse for bone cancers. Efficient mitochondria targeted delivery and tumor eradication with nano hydroxyapatite containing doxorubicin ». Materials Today Bio 14 (mars 2022) : 100227. http://dx.doi.org/10.1016/j.mtbio.2022.100227.

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Strauch, Bettina Maria, Wera Hubele et Andrea Hartwig. « Impact of Endocytosis and Lysosomal Acidification on the Toxicity of Copper Oxide Nano- and Microsized Particles : Uptake and Gene Expression Related to Oxidative Stress and the DNA Damage Response ». Nanomaterials 10, no 4 (3 avril 2020) : 679. http://dx.doi.org/10.3390/nano10040679.

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The toxicity of the copper oxide nanoparticles (CuO NP) has been attributed to the so-called “Trojan horse”-type mechanism, relying on the particle uptake and extensive intracellular release of copper ions, due to acidic pH in the lysosomes. Nevertheless, a clear distinction between extra- and intracellular-mediated effects is still missing. Therefore, the impact of the endocytosis inhibitor hydroxy-dynasore (OH-dyn), as well as bafilomycin A1 (bafA1), inhibiting the vacuolar type H+-ATPase (V-ATPase), on the cellular toxicity of nano- and microsized CuO particles, was investigated in BEAS 2 B cells. Selected endpoints were cytotoxicity, copper uptake, glutathione (GSH) levels, and the transcriptional DNA damage and (oxidative) stress response using the high-throughput reverse transcription quantitative polymerase chain reaction (RT-qPCR). OH-dyn markedly reduced intracellular copper accumulation in the cases of CuO NP and CuO MP; the modulation of gene expression, induced by both particle types affecting especially HMOX1, HSPA1A, MT1X, SCL30A1, IL8 and GADD45A, were completely abolished. BafA1 lowered the intracellular copper concentration in case of CuO NP and strongly reduced transcriptional changes, while any CuO MP-mediated effects were not affected by bafA1. In conclusion, the toxicity of CuO NP depended almost exclusively upon dynamin-dependent endocytosis and the intracellular release of redox-active copper ions due to lysosomal acidification, while particle interactions with cellular membranes appeared to be not relevant.
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Zhang, Lei, Hai-Yan Wang, Mu-Qiong Li, Xi-Xi Wang, Li Fan et Yu-Sheng Wang. « A Trojan horse biomimetic delivery system using mesenchymal stem cells for HIF-1α siRNA-loaded nanoparticles on retinal pigment epithelial cells under hypoxia environment ». International Journal of Ophthalmology 15, no 11 (18 novembre 2022) : 1743–51. http://dx.doi.org/10.18240/ijo.2022.11.03.

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AIM: To demonstrate the feasibility of mesenchymal stem cell (MSC)-mediated nano drug delivery, which was characterized by the “Trojan horse”-like transport of hypoxia-inducible factor-1α small interfering RNA (HIF-1α siRNA) between MSCs and retinal pigment epithelial cells (RPE) under hypoxia environment. METHODS: Plasmid and lentivirus targeting the human HIF-1α gene were designed and constructed. HIF-1α siRNA was encapsulated into poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) through the water-in-oil-in-water (w/o/w) multiple emulsion technique. The effect of PLGA-NPs uptake on the expression of HIF-1α mRNA was tested in RPE cells by real-time quantitative polymerase chain reaction (qPCR) and additional transfected conditions were used as control, including lentivirus group, nude plasmid group and blank PLGA group. MSCs were transfected with the NPs and the transfection efficacy was evaluated by flow cytometry. Transwell co-culture system of transfected MSCs and RPE cells was constructed under hypoxia environment. The effects of MSC-loaded HIF-1α siRNA PLGA-NPs on proliferation, apoptosis, and migration of RPE cells were then evaluated. The effect of transfected MSCs on HIF-1α expression of RPE cells was analyzed by using qPCR at the time points 24h, 3d, and 7d. RESULTS: The average diameter of PLGA-NPs loaded with HIF siRNA was 314.1 nm and the zeta potential was -0.36 mV. The transfection efficiency of PLGA-NPs was 67.3%±5.2% into MSCs by using flow cytometry. Compared with the lentivirus group, the PLGA-NPs loaded with HIF-1α siRNA can effectively reduce the expression of HIF-1α mRNA up to 7d in RPE (0.63±0.05 at 7d, P<0.001). In the Transwell co-culture system of transfected MSCs and RPE, the abilities of proliferation (2.34±0.17, 2.40±0.28, 2.47±0.24 at 48h, F=0.23, P=0.80), apoptosis (14.83%±2.43%, 12.94%±2.19%, 12.39%±3.21%; F=0.70, P=0.53) and migration (124.5±7.78, 119.5±5.32, 130±9.89, F=1.33, P=0.33) of the RPE cells had no differences between MSC-loaded HIF-1α siRNA PLGA-NPs and other groups. The inhibition of PLGA on the HIF-1α mRNA expression in RPE cells could continue until the 7th day, the level of HIF-1α mRNA was lower than that of other groups (F=171.98, P<0.001). CONCLUSION: The delivery of PLGA-NPs loaded with HIF-1α siRNA carried by MSCs is found to be beneficial temporally for HIF-1α mRNA inhibition in RPE cells under hypoxia environment. The MSC-based bio-mimetic delivery of HIF-1α siRNA nanoparticles is a potential method for therapy against choroidal neovascularization.
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Bhatti, Manpreet, Timothy D. McHugh, Lilia Milanesi et Salvador Tomas. « Self-assembled nanoparticles as multifunctional drugs for anti-microbial therapies ». Chem. Commun. 50, no 57 (2014) : 7649–51. http://dx.doi.org/10.1039/c4cc00349g.

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Hasanova, Ulviyya Alimammad, Mahammadali Ahmad Ramazanov, Abel Mammadali Maharramov, Qoncha Malik Eyvazova, Zohrab Adalet Agamaliyev, Yana Vacheslav Parfyonova, Sarvinaz Faiq Hajiyeva, Flora Vidadi Hajiyeva et Solmaz Bayram Veliyeva. « Nano-Coupling of Cephalosporin Antibiotics with Fe<SUB>3</SUB>O<SUB>4</SUB> ; Nanoparticles : Trojan Horse Approach in Antimicrobial Chemotherapy of Infections Caused by <i>Klebsiella spp</i>. » Journal of Biomaterials and Nanobiotechnology 06, no 03 (2015) : 225–35. http://dx.doi.org/10.4236/jbnb.2015.63021.

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Engelhaupt, Erika, Lizz Thrall, Barbara Booth et Rhitu Chaterjee. « Clearing the air on ethanol | A nano Trojan horse | Perfume, perfume everywhere | News Briefs : Montreal beats Kyoto on climate controls ` Bigger fish to fry ? ` Asian pollution strengthens storms ` Snapping fluorocarbon superbonds ` New aerosol source ` Snapping fluorocarbon superbonds | Perchlorate from fireworks | Seeing the forest for the methane | Thailand fuels up with cassava ». Environmental Science & ; Technology 41, no 11 (juin 2007) : 3788–94. http://dx.doi.org/10.1021/es072543f.

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Thèses sur le sujet "Trojan Nano Horse"

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RACCA, LUISA. « Study of a new ultrasound-based device in combination with smart nanoparticles for the treatment of cancer ». Doctoral thesis, Politecnico di Torino, 2020. http://hdl.handle.net/11583/2827701.

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Chapitres de livres sur le sujet "Trojan Nano Horse"

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Muthukrishnan, Lakshmipathy. « Encountering the Survival Strategies Using Various Nano Assemblages ». Dans Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer, 159–87. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5049-6.ch007.

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The technological advancements have not only made humans more civilized but have also caused the micro-organisms to develop several survival strategies via antimicrobial resistance to keep pace. Such highly developed microbial systems have been classified as superbugs, exhibiting Trojan-horse mechanism. This uncertain behaviour in microbes has challenged humans to scour around novel moiety to shield themselves from the detrimental effects. One such natural phenomenon that has drawn the attention of researchers is the metal-microbe interaction where microbes were found to be controlled during their interaction with metals. Fine tuning could bestow them with enhanced physico-chemical properties capable of controlling life-threatening micro-organisms. Nano forms of metals (nanoparticles, quantum dots, polymeric nanostructures) exhibiting medicinal properties have been implied toward biomedical theranostics. This chapter highlights the mechanistic antimicrobial resistance and the containment strategy using various nano assemblage highlighting its fabrication and bio-molecular interaction.
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