Littérature scientifique sur le sujet « Triterpènes – Recherche »
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Articles de revues sur le sujet "Triterpènes – Recherche"
Damando, Daisy, B. Gérard Josias Yaméogo, Hermine Zimé-Diawara, Marcel Sawadogo, Boukaré Kaboré, Moumouni Koala, Félix Yaméogo et al. « Analyse phytochimique et évaluation de l’activité larvicide contre le vecteur de la dengue (Aedes aegypti) d’extraits de feuilles de Calotropis procera R. br (Apocynaceae) en vue de leur utilisation comme bio-insecticide ». Journal Africain de Technologie Pharmaceutique et Biopharmacie (JATPB) 2, no 3 (20 décembre 2023). http://dx.doi.org/10.57220/jatpb.v2i3.103.
Texte intégralThèses sur le sujet "Triterpènes – Recherche"
Almahli, Hadia. « Recherche de triterpénoîdes hémisynthétique à activités pharmacologiques ». Paris 11, 2009. http://www.theses.fr/2009PA114819.
Texte intégralFunel-Le, Bon Corinne. « Recherche de molécules antitumorales d'éponges marines de la famille des axinellidae ». Nice, 2004. http://www.theses.fr/2004NICE4002.
Texte intégralThe aim of this work was to identify antitumoral molecules in marine organisms. We performed the chemical analyses of two sponges of the Axinellidae family from the Indian Ocean. Liquid extraction, chromatography and high performance liquid chromatography were realized. The structural determination was accomplished by performing usual spectroscopic methods, notably nuclear magnetic resonance (NMR). The studies of Axinella cf. Bidderi and Axinella weltneri using bioassay fractionation led to isolation of 12 molecules with 5 new structures including sterols and triterpenes. The cytotoxic activity was evaluated against human tumoral cell lines
Tsoukalas, Michail. « Recherche de sécrétagogues naturels du GLP-1 : exploration du potentiel antidiabétique d'espèces du genre Cynanchum (Apocynaceae) ». Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF047/document.
Texte intégralIn the framework of our search for antidiabetic compounds capable of stimulating the secretion of the hypoglycemic hormone GLP-1 (glucagon-like-peptide 1), based on ethnopharmacological and taxomic criteria, several Asclepiadoidae plants were screened with an in vitro model (STC-1 cell line). This approach led to the selection of two Malagasy Cynanchum species.Bio-guided fractionation of C. marnierianum led to the purification of two new pregnane glycosides named marnieranosides. The phytochemical study of C. menarandrense led to the identification of 5 new pregnane structures along with 2 pregnanes previously reported in the closely related and hypoglycemic Caralluma genus. The isolated pregnanes were evaluated for their GLP-1 secretagogue and cytotoxic activity but only the marnieranosides were proven bioactive. Structural similarities of the Cynanchum pregnanes with the ones previously isolated from antidiabetic plants (Hoodia and Caralluma), validated our approach for the discovery of secondary metabolites with antidiabetic potential
Welti, Stéphane. « Recherches de substances antitumorales à partir de ganodermes et autres polypores récoltés dans les îles françaises des petites Antilles et contribution à l'inventaire des Ganodermataceae de Martinique, Guadeloupe et dépendances ». Lille 2, 2009. http://www.theses.fr/2009LIL2S034.
Texte intégralMarchal, Axel. « Recherches sur les bases moléculaires de la saveur sucrée des vins secs : approches analytique et sensorielle ». Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21779/document.
Texte intégralSweetness contributes to the balance in taste of dry wines. An increase in sweet taste isobservable during post-fermentation maceration and oak-barrel aging. We have revealed thatthese phenomena are respectively due to the release in wines of yeast peptides and nonvolatileoak wood compounds.The role of Hsp12 protein from S.cerevisae on the increase in sweetness is establishedwith both molecular biology and sensorial analysis techniques.The development of a method coupling centrifugal partition chromatography andgustatometry has enabled us to fractionate an oak-wood extract and to purify several sapidcompounds. Thanks to both the LC-FTMS and the NMR spectroscopy methods, we havehighlighted four new molecules, called quercotriterpenosides (QTT), out of which QTT Iand III are responsible for a sweet taste. The perception thresholds of QTT I and a bitterlignan, lyoniresinol, are respectively 590 μg/L and 1.52 mg/L.LC-FT/MS method has been used to develop a quantification method for these compoundsand we have demonstrated the organoleptic impact of lyoniresinol in wines.QTT I and III are likely to contribute, directly or indirectly, to the increase in sweetnessconsecutive to barrel aging in dry wines
Welti, Stephane. « Recherches de substances antitumorales à partir de ganodermes et autres polypores récoltés dans les îles françaises des petites Antilles et contribution à l'inventaire des Ganodermataceae de Martinique, Guadeloupe et dépendances ». Phd thesis, Université du Droit et de la Santé - Lille II, 2009. http://tel.archives-ouvertes.fr/tel-00441072.
Texte intégralCordonnier, Julien. « Toxoplasma gondii : identification par docking inverse sur des cibles moléculaires de composés actifs issus de ressources naturelles ». Electronic Thesis or Diss., Reims, 2024. http://www.theses.fr/2024REIMS001.
Texte intégralTree barks, by-product of forestry industry, constitute an abundant and sustainable source of natural compounds. Toxoplasma gondii is the parasite responsible for toxoplasmosis, posing a threat to fetuses, newborns, and immunocompromised individuals. The current therapeutics, limited and poorly tolerated, are now confronted to chemoresistant phenomena. This doctoral project aims to explore the chemical space associated with tree barks from the Champagne-Ardenne region, as relevant protein targets to fight T. gondii. An initial in silico evaluation using reverse docking (AMIDEv2.0) was carried out to identify biological target for triterpenes derived from betulone, isolated from the European alder, which had exhibited in vitro anti-toxoplasmosis activity. Among 87 proteins of T. gondii, CDPK3 was identified as the most probable target. Subsequently, a bank of 25 essential 3D protein structures for parasite survival, including 19 homology-modeled structures, was compiled. Thereafter, compounds from the Essential National Chemical Library were screened against this protein bank, using AMIDEv2.0. Two proteins were identified as potential targets; one of them was ATG3, a protein structure modeled from homologs with less than 50% identity. Subsequently, the barks of European Larch, whose n-heptane extract had shown significant activity (58% inhibition of parasitic growth at 100 µg/ml), were subjected to a chemical profiling. First, through a fractionation process using Centrifugal Partition Chromatography, and then a dereplication approach combining data from nuclear magnetic resonance and mass spectrometry. Tools like VersaDB and CATHEDRAL were developed to facilitate the creation of custom-databases and assess the confidence level of annotations. 52 molecules were annotated and associated with a confidence score. Simultaneously, in vitro tests demonstrated that 2 out of the 12 CPC fractions, primarily composed of terpenic derivatives, inhibited the parasite's survival by more than 40% at 25 µg/ml. Ultimately, the annotated compounds from L. decidua were subjected to AMIDEv2.0. The overlap between in vitro and in silico results highlighted 7-oxo-dehydroabietic acid and daniellic acid, strongly correlated with the in vitro inhibitory activity of the barks. CDPK1 and the SET-containing Protein are likely protein targets for these two ligands, thereby providing initial insights into their mechanism of action. These two hits are currently undergoing in vitro evaluation to verify the efficiency of developed approach during this doctoral project