Littérature scientifique sur le sujet « TREK-1 potassium channel »
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Articles de revues sur le sujet "TREK-1 potassium channel"
Pike, Ashley, Yin Dong, Alexandra Mackenzie, Conor McClenaghan, Shubhashish Mukhopadhyay, Nicola Burgess-Brown, Stephen Tucker et Elisabeth Carpenter. « Structures of the human two-pore domain potassium channels TREK-1 and TREK-2 ». Acta Crystallographica Section A Foundations and Advances 70, a1 (5 août 2014) : C1489. http://dx.doi.org/10.1107/s2053273314085106.
Texte intégralLevitz, Joshua, Perrine Royal, Yannick Comoglio, Brigitte Wdziekonski, Sébastien Schaub, Daniel M. Clemens, Ehud Y. Isacoff et Guillaume Sandoz. « Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels ». Proceedings of the National Academy of Sciences 113, no 15 (28 mars 2016) : 4194–99. http://dx.doi.org/10.1073/pnas.1522459113.
Texte intégralBrenner, Tanja, et Kevin M. O'Shaughnessy. « Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion ». American Journal of Physiology-Endocrinology and Metabolism 295, no 6 (décembre 2008) : E1480—E1486. http://dx.doi.org/10.1152/ajpendo.90652.2008.
Texte intégralBlin, Sandy, Ismail Ben Soussia, Eun-Jin Kim, Frédéric Brau, Dawon Kang, Florian Lesage et Delphine Bichet. « Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties ». Proceedings of the National Academy of Sciences 113, no 15 (28 mars 2016) : 4200–4205. http://dx.doi.org/10.1073/pnas.1522748113.
Texte intégralRichter, Trevor A., Gennady A. Dvoryanchikov, Nirupa Chaudhari et Stephen D. Roper. « Acid-Sensitive Two-Pore Domain Potassium (K2P) Channels in Mouse Taste Buds ». Journal of Neurophysiology 92, no 3 (septembre 2004) : 1928–36. http://dx.doi.org/10.1152/jn.00273.2004.
Texte intégralWiedmann, Felix, Daniel Schlund, Francisco Faustino, Manuel Kraft, Antonius Ratte, Dierk Thomas, Hugo A. Katus et Constanze Schmidt. « N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels ». International Journal of Molecular Sciences 20, no 20 (20 octobre 2019) : 5193. http://dx.doi.org/10.3390/ijms20205193.
Texte intégralPineda, Ricardo H., Balachandar Nedumaran, Joseph Hypolite, Xiao-Qing Pan, Shandra Wilson, Randall B. Meacham et Anna P. Malykhina. « Altered expression and modulation of the two-pore-domain (K2P) mechanogated potassium channel TREK-1 in overactive human detrusor ». American Journal of Physiology-Renal Physiology 313, no 2 (1 août 2017) : F535—F546. http://dx.doi.org/10.1152/ajprenal.00638.2016.
Texte intégralNamiranian, Khodadad, Eric E. Lloyd, Randy F. Crossland, Sean P. Marrelli, George E. Taffet, Anilkumar K. Reddy, Craig J. Hartley et Robert M. Bryan. « Cerebrovascular responses in mice deficient in the potassium channel, TREK-1 ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 299, no 2 (août 2010) : R461—R469. http://dx.doi.org/10.1152/ajpregu.00057.2010.
Texte intégralYeliashov, S. I., B. R. Sharopov et Ya M. Shuba. « ROLE OF POTASSIUM CHANNEL TREK-1 IN MECHANOSENSITIVITY OF SMOOTH MUSCLE CELLS FROM RAT DETRUSOR ». Fiziolohichnyĭ zhurnal 70, no 2 (5 février 2024) : 43–50. http://dx.doi.org/10.15407/fz70.02.035.
Texte intégralVallee, Nicolas, Cédric Meckler, Jean-Jacques Risso et Jean-Eric Blatteau. « Neuroprotective role of the TREK-1 channel in decompression sickness ». Journal of Applied Physiology 112, no 7 (1 avril 2012) : 1191–96. http://dx.doi.org/10.1152/japplphysiol.01100.2011.
Texte intégralThèses sur le sujet "TREK-1 potassium channel"
Cuménal, Mélissa. « Recherche de nouvelles cibles moléculaires pour le traitement de la douleur osseuse du cancer de la prostate ». Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2021. http://theses.bu.uca.fr/nondiff/2021UCFAC114_CUMENAL.pdf.
Texte intégralProstate (PCa), breast and lung cancer are often difficult to diagnose due to their initial asymptomatic nature. Rarely painful in the primary stages, these cancers have a high propensity to metastasize to the bone microenvironment. Clinically, at this stage, this translates into pain that is both very disabling and resistant to standard analgesic treatments, including morphine. The difficulty comes from the multifactorial nature of this pain, which combines nociceptive and neuropathic components. Among the factors attributed to cancer pain, an essential role is attributed to the disruption of the nervous system (peripheral and central) and to tumor growth, both of which affect the bone microenvironment.Glutamate, a major excitatory neurotransmitter of the nervous system, has recently emerged as a potential target in the management of solid cancers, including PCa. Riluzole, an anti glutamatergic molecule, which is authorized for the treatment of ALS, has demonstrated an analgesic effect in several inflammatory and neuropathic pain models and an antiproliferative effect in vitro. Therefore, we investigated whether this molecule could have beneficial effects in the treatment of PCa-induced bone pain, and how it could influence the development of bone metastatic PCa. We used a bone pain model by intratibial injection of human PCa cells, PC3-luc cells, and administered riluzole in the drinking water. In this model, riluzole demonstrated a significant analgesic effect involving the TREK-1 channel, a selective channel for potassium ions. In addition, riluzole significantly decreased cell viability in vitro and slowed tumor growth in vivo without affecting bone remodeling. The antiproliferative effect of riluzole would imply an increase in the expression of TREK-1 channels in PC3 cells participating in their hyperpolarization.In conclusion, this work highlights the importance of riluzole as a molecule of interest for the treatment of PCa bone pain whose mechanism of action certainly involves the TREK-1 potassium channel
Vivier, Delphine. « Vers de nouveaux antalgiques : optimisation de molécules activatrices des canaux potassiques TREK-1 ». Thesis, Clermont-Ferrand 2, 2014. http://www.theses.fr/2014CLF22518/document.
Texte intégralMorphine remains the analgesic of reference for the treatment of pain (nociception), but it is also responsible for serious adverse effects. Research studies have shown that animals deprived of potassium channels TREK-1 (TWIK-related K+ channels) were over-sensitive to pain. More recently, it has been demonstrated that the TREK-1 potassium channel is a crucial contributor of morphine-induced analgesia in mice, while it is not involved in morphine-induced constipation, respiratory depression and dependence. These results suggest that the TREK-1 channels constitute targets of interest for the design of novel analgesics without opioid-like adverse effects. Previous studies within our consortium led to the identification of four lead structures as TREK-1 activators exhibiting analgesic activity in vivo.Since the 3D structure of TREK-1 was not available at the time, we decided to perform hit optimization by conventional structure-activity relationship (SAR) studies. Thirty six analogs were synthesized via Knoevenagel condensation and evaluated for their analgesic effect (writhing test, hot plate assay) and their ability to activate TREK-1 channel (electrophysiology). It turned out that the possibility to form hydrogen bonding interaction (aryl moiety) and the volume of substituents of the amide or ester has a crucial influence on activity. Promising results emerged from this SAR study: 5 molecules display a very good analgesic activity (> 50% inhibition of pain, hot plate assay) as well as a good activation of TREK-1 channels (R ≥ 2 at 10μM or R ≥ 4 above 20μM)
Innamaa, Anni. « Expression and function of the two pore potassium (K2P) channels TREK-1, TREK-2 and TASK-3 in ovarian cancer ». Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606812.
Texte intégralKennard, Louise Elizabeth. « Functional properties and regulation of the two-pore domain potassium channels TREK-1 and TASK-3 ». Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497890.
Texte intégralRodrigues, Nuno. « Recherche et évaluation d'antalgiques originaux : les activateurs des canaux potassiques TREK-1 ». Thesis, Clermont-Ferrand 2, 2011. http://www.theses.fr/2011CLF22181.
Texte intégralAnalgesics used today are old products and several of them date from the 19th century. Morphine remains the analgesics of reference for pains called by excess of nociception, but it is at the origin of awkward and serious side effects. It was shown that the analgesic effect of morphine passed by the activation of potassium channels TREK-1. The objective of this work is thus to develop original analgesics, activators of TREK-1. We synthesized activators of TREK-1 described in the literature and we evaluated their analgesic activity in vivo (writhing test) which enabled us to identify CDC as a lead molecule. We then synthesized 43 analogues of CDC which we evaluated for their analgesic effect and their ability to activate TREK-1 channels (electrophysiology). These molecules were prepared in 3 to 12 steps with yields ranging from 3 to 72 % by using reactions such as : aldol reaction, Watsworth and Horner’s olefination, Peterson’s olefination, esterification … Very promising results emerged from this structure-activity relationship study with 8 molecules which display a very good analgesic effect (>50% inhibition of pain) as well as a good activation of TREK-1 channels (R> 2). Finally we analyzed the results of this study by molecular modeling (QSAR) which enabled us to identify the essential structural characteristics of these molecules
Li, Xiantao [Verfasser]. « The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle / vorgelegt von Xiantao Li ». 2005. http://d-nb.info/977904334/34.
Texte intégralChoudhury, Nasreen. « G-Protein Coupled Estrogen Receptor (hGPER)- Mediated Action of 17β-Estradiol on hTREK-1 Potassium Channel ». Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4159.
Texte intégralHarinath, S. « Pharmacological Modulation Of Recombinant Human Two-Pore Domain K+ Channels : Whole-Cell patch-Clamp Analysis ». Thesis, 2005. https://etd.iisc.ac.in/handle/2005/1501.
Texte intégralHarinath, S. « Pharmacological Modulation Of Recombinant Human Two-Pore Domain K+ Channels : Whole-Cell patch-Clamp Analysis ». Thesis, 2005. http://etd.iisc.ernet.in/handle/2005/1501.
Texte intégralChapitres de livres sur le sujet "TREK-1 potassium channel"
Tse, Amy, Andy K. Lee et Frederick W. Tse. « Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes ». Dans Neurosecretion : Secretory Mechanisms, 219–39. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-22989-4_11.
Texte intégralLicher, Thomas. « TREK-1 Potassium Channel ». Dans xPharm : The Comprehensive Pharmacology Reference, 1–7. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.60437-4.
Texte intégralActes de conférences sur le sujet "TREK-1 potassium channel"
Zyrianova, T., B. Lopez, D. Pham, A. Ye et A. Schwingshackl. « TREK-1 Potassium Channel Activation Protects Against Influenza-A Induced Lung Injury ». Dans American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3458.
Texte intégralImmanuel, C. N., B. Lopez, B. Teng, B. Dong, E. M. Gordon, A. Schwingshackl et C. M. Waters. « Two Pore Potassium Channel TREK-1 Regulates K+ Efflux and Membrane Potential in Macrophages ». Dans American Thoracic Society 2023 International Conference, May 19-24, 2023 - Washington, DC. American Thoracic Society, 2023. http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4437.
Texte intégralSchwingshackl, Andreas, Bin Teng, Patrudu S. Makena, Vijay K. Gorantla, Alina N. West, Manik C. Ghosh et Christopher M. Waters. « Regulation And Function Of The Two-Pore-Domain Potassium (K2P) Channel Trek-1 In Acute Lung Injury ». Dans American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4235.
Texte intégralZyrianova, T., B. Lopez, L. Wong, S. Talapaneni, C. Gu, R. Olcese, D. L. Minor, C. M. Waters et A. Schwingshackl. « Activation of TREK-1 Potassium Channels Protects from Hyperoxia-Induced Lung Injury ». Dans American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5550.
Texte intégralSchwingshackl, A., B. Lopez, C. M. Waters, A. Wei et R. Olcese. « Structural Composition and Signaling Pathways of Alveolar Epithelial TREK-1 Potassium Channels ». Dans American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2116.
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