Thèses sur le sujet « Transcription factors »
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Yao, Ya-Li. « Regulation of yy1, a multifunctional transciption [sic] factor / ». [Tampa, Fla.] : University of South Florida, 2001. http://purl.fcla.edu/fcla/etd/SFE0000626.
Texte intégralZandvakili, Arya. « The Role of Affinity and Arrangement of Transcription Factor Binding Sites in Determining Hox-regulated Gene Expression Patterns ». University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535708748728472.
Texte intégralElzi, David John. « Transcriptional properties of the Kaiso class of transcription factors / ». Thesis, Connect to this title online ; UW restricted, 2007. http://hdl.handle.net/1773/5027.
Texte intégralBidon, Baptiste. « Mediator and NER factors in transcription initiation ». Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ093/document.
Texte intégralThe synthesis of messenger RNA is a highly regulated process. During transcription initiation, a large number of proteins are recruited to gene promoter, including the RNA polymerase II, general transcription factors, co-activators, chromatin remodellers and the Mediator complex. Some DNA repair factors from the NER pathway are also recruited. Using cells derived from patients bearing mutations in either MED12 gene or XPC gene, we studied the roles of such proteins in transcription. MED12 patients are mostly characterised by intellectual disability and developmental delay. We showed that MED12 is implicated in the transcription regulation of immediate early genes like JUN, known for its role in neurological development and neuronal plasticity. JUN expression is markedly altered by MED12 mutations. We also showed that the position of the mutation influences this alteration, bringing possible explanation for inter-patients symptom variability. Meanwhile, XPC patients are mostly characterized by photosensitivity. We showed that XPC protein, which engages one of the NER pathways, is implicated in chromatin post-translational modification. Together with E2F1, it helps the recruitment of GCN5 acetyl-transferase to promoter of a certain set of genes. On the promoter, GCN5 notably cooperates with TFIIH to modify the chromatin environment during transcription initiation. In addition to help the comprehension of the transcription mechanisms, these results bring knew insight into the aetiology of mutations associated diseases
Brunkhorst, Adrian. « A study on the TFIID subunit TAF4 / ». Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-206-3/.
Texte intégralDennis, Jonathan Hancock. « Transcriptional regulation by Brn 3 POU domain containing transcription factors ». Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249684.
Texte intégralGreberg, Maria Hellqvist. « Cloning and characterization of FREACs, human forkhead transcription factors ». Göteborg : Dept. of Cell and Molecular Biology, Göteborg University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751934.html.
Texte intégralChanapai, Seni. « Photocontrol of artificial transcription factors ». Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/58014/.
Texte intégralMekala, Vijaya Krishna Wysocka-Diller Joanna. « Isolation and characterization of Scarecrow suppressor mutants in Arabidopsis thaliana ». Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/FALL/Biological_Sciences/Thesis/Mekala_Vijaya_18.pdf.
Texte intégralChing, Chi-yun Johannes, et 程子忻. « Transcriptional regulation of p16INK4a expression by the forkhead box transcription factor FOXM1 ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29466192.
Texte intégralPinacho, Garcia Raquel. « SP Transcription factors in psychotic disorders ». Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/327025.
Texte intégralMüller, Susanne. « Transcription factors regulating the Btk promoter / ». Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2717-0.
Texte intégralPaik, Elizabeth Jae-Eun. « Caudal Transcription Factors in Hematopoietic Development ». Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10254.
Texte intégralCostanzo, Federico. « Role of NER factors in transcription ». Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ099.
Texte intégralMutations in genes coding for NER factors give rise to autosomal recessive diseases such as Xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The phenotypes associated with these genetic syndromes spans from extreme sensitivity to UV light, with increased predisposition to cancer (for XP and combined XP/CS, mostly), mental retardation and progeria (for CS and combined XP/CS). Whether the correlation between defective DNA repair reactions and UV-sensitivity/cancer may be more intuitive, a link with neurological/progeroid symptoms is still a matter of debate. As a possible explanation, it has been proposed a connection between NER and transcription regulation. We propose additional insights on XPG and XPC roles in transcription regulation in absence of exogenous stress and how CSA and CSB orchestrate transcription arrest due to genotoxic attack. XPC was able to stably interact with NSD3 methyltransferase. Mutations in XPC also disturbed the transcriptome and the H3K36me3 distribution. Mutations in XPG deregulate gene expression and XPG is able to be recruited genome wide together with TFIIH. CSA and CSB can, as part of the ubiquitin/proteasome machinery, regulate the recruitment timing of DNA binding factors and control transcriptional program after UV irradiation. Hence, our data shed more light in NER factors role in transcription and their defective action as a cause of XP and XP/CS disorders. Additionally, our data provide explanations on the mechanism of transcription arrest following genotoxic stress and pose questions about the origins of CS phenotype
Grossman, Sharon R. (Sharon Rachel). « Combinatorial gene regulation by transcription factors ». Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/128406.
Texte intégralCataloged from PDF of thesis. "The Table of Contents does not accurately represent the page numbering"--Disclaimer page.
Includes bibliographical references.
Combinatorial gene regulation is encoded in enhancers and promoters in the form of binding sites for transcription factors (TFs), which collaboratively recruit the transcriptional machinery and drive gene expression. Using high-throughput and quantitative technologies developed by our lab and others, we studied TF binding sites in enhancers from numerous different cell types and regulatory systems, shedding light general principles of motif composition and organization in typical cellular regulatory elements. We find extensive synergy between TF binding sites, some with organizational constraints and some with flexible positioning. We demonstrate that different TFs bind at distinct positions within regulatory elements, suggesting a new type of architectural constraint in enhancers. Importantly, our analysis of both TF organization and cooperativity revealed distinctive patterns that separates TFs into potential functional classes. Together, our results suggest a structure of the regulatory code at the level of TF function and generate new hypotheses about regiospecific binding patterns and functions of TF classes within enhancers.
by Sharon R. Grossman.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biology
Montelius, Andreas. « Role of transcription factors in sensory neuron specification / ». Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-115-9/.
Texte intégralJadlowsky, Julie Kendal. « Dual control of HIV transcription elongation virus-specific negative control by NELF-E is counterbalanced by positive transcription factor P-TEFb / ». Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1228234927.
Texte intégralCusack, Martin. « The role of DNA methylation on transcription factor occupancy and transcriptional activity ». Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:7d0b7fe7-dee1-433f-8656-c9ee2a216d48.
Texte intégralLi, Yuxin. « The DEC1 transcription factor : oncogenic involvement and molecular mechanisms on transcription regulation / ». View online ; access limited to URI, 2003. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3115632.
Texte intégralEustis, Robyn Lynn. « The Role of Pyrococcus furiosus Transcription Factor E in Transcription Iniitiation ». PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2522.
Texte intégralSICILIANO, DILETTA. « ANALYSIS OF THE TRANSCRIPTIONAL REGULATION OF MTORC1 ACTIVITY BY MIT/TFE TRANSCRIPTION FACTORS ». Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/607642.
Texte intégralFerguson, Laura A. « The insulin promoter ». Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25965.
Texte intégralBhattarai, Arati. « The orientation of the Pyrococcus furiosus transcription factor TFB2 in the transcription initiation complex ». PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/1938.
Texte intégralTai, C. P. Andrew. « An in vivo analysis of specificity of gene transactivation by SOX proteins ». Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36906438.
Texte intégralTai, C. P. Andrew, et 戴賜鵬. « An in vivo analysis of specificity of gene transactivation by SOX proteins ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36906438.
Texte intégralGueroult, bellone Marion. « Signatures nucléotidiques de l'activité des enhancers développementaux chez l'ascidie Ciona intestinalis ». Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTS029.
Texte intégralEnhancers are crucial elements for the control of gene expression during embryonic development. The ascidian Ciona intestinalis offers unique experimental features to study these cis-regulatory sequences: enhancers are generally small and compact and their activity can be tracked at the single cell level thanks to the invariant cell lineage of ascidian embryos.Previous work identified two independent signatures associated with enhancer activity: the presence of specific transcription factors binding sites (TFBS) and a global dinucleotide signature along enhancers (Khoueiry, 2010). Although they correlate with enhancer activity, these signatures are insufficient to identify enhancer sequences from their sole sequence. During my thesis, I used a well-characterized early neural Ciona enhancer, the a-element of the Otx gene, as a model enhancer. This small (55pb) enhancer, is bound by GATA-a and ETS1/2 and is activated by the FGF pathway. To better understand the determinants of early neural enhancer activity, I tested the impact of point mutations affecting the affinity of the a-element TFBS for their binding TF and of the randomization of the spacer sequences that separate the TFBS in four ETS and GATA binding site clusters.Our results suggest at least two levels of cis-regulatory control: spatiotemporal specificity of enhancer activity is encoded in the identity of TF-binding sites, while the level of enhancer activity is set both by the affinity of TFs for their binding sites and by the composition of the spacer sequences. A surprisingly high number of variants of the a-element with randomized spacers are active, always in the same cell lineages as the WT. These variants, however, display a wide range of activity levels. This effect is also observed when the spacers in another active ETS/GATA cluster are randomized. Randomization of the spacers can even confer enhancer activity to a large fraction of inactive cluster variants. Consistent with their early neural activity and with the presence of ETS- and GATA-binding sites, these variants are, like the a-element, responsive to the FGF neural inducer.We could not link the action of the spacers on enhancer activity to any simple nucleotide or dinucleotide sequence features and it currently remains unclear why it is so easy to create a synthetic enhancer while most putative genomic ETS/GATA clusters are inactive. Using in vitro transcription factor binding assays, we showed that randomization of spacer sequences can affect TF binding to the a-element without changing the primary sequence of the binding site, and that extended minimal TFBS do not always recapitulate binding to the whole element. These results suggest that the physical structure of the DNA helix around the binding sites may play an important role in the control of enhancer activity
Castro-Mondragon, Jaime. « Development of bioinformatics methods for the analysis of large collections of transcription factor binding motifs : positional motif enrichment and motif clustering ». Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0171.
Texte intégralTranscription Factors (TFs) are DNA-binding proteins that control gene expression. TF binding motifs (TFBMs, simply called “motifs”) are usually represented as Position Specific Scoring Matrices (PSSMs), which can be visualized as sequence logos. The advent of high-throughput methods has allowed the detection of thousands of motifs which are usually stored in databases. In this work I developed two novel methods and implemented software tools to handle large collection of motifs in order to extract interpretable information from high-throughput data: (i) matrix-clustering regroups motifs by similarity and offers a dynamic interface; (2) position-scan detects TFBMs with positional preferences relative to a given reference location (e.g. ChIP-seq peaks, transcription start sites). The methods I developed have been evaluated based on control cases, and applied to extract meaningful information from different datasets from Drosophila melanogaster and Homo sapiens. The results show that these methods enable to analyse motifs in high-throughput datasets, and can be integrated in motif analysis workflows
Koo, Sonya Janet. « Downstream targets of motor neuron transcription factors / ». Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3190171.
Texte intégralKinyanjui, Margaret. « Targeting Th2 transcription factors in experimental asthma ». Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18717.
Texte intégralLes cellules CD4+ T à antigènes spécifiques transfèrent par adoption l'inflammation pulmonaire constituées principalement de lymphocytes et d'éosinophiles. L'habileté de celles-ci à transférer des cellules T pour induire l'inflammation est dépendante de leur expression de cytokines Th2. De manière à mieux comprendre le mécanisme par lequel les cellules T transmises par adoption induisent l'inflammation pulmonaire, nous avons choisi de moduler l'expression de GATA-3) ou l'activité de (STAT-6) des deux régulateurs-clés de production de cytokine Th2. Afin de modifier l'expression de GATA-3 dans les cellules T destinées au transfert par adoption, nous avons utilisé un rétrovirus recombinant concentré avec une filtration par centrifugeuse. Ce procédé a dramatiquement augmenté leurs titres et ainsi leur habileté à transduire les cellules CD4+ T en culture primaire. Nous avons utilisé un rétrovirus recombinant qui encode la GATA-3 et / ou la protéine fluorescente verte (EGFP). En couplant in vitro la stimulation d'antigènes avec la transduction par vecteur viral, nous avons généré des cellules CD4+ T à antigènes spécifiques exprimant de l'EGFP seul ou bien de la GATA-3 et de l'EGFP. Lorsque transféré dans un rat qui avait subséquemment été provoqué avec des antigènes, ces cellules CD4+ T induisent une réaction aux inflammations pulmonaires avec une augmentation des lymphocytes et éosinophiles. Cette réaction inflammatoire fut accrue chez les animaux recevant les cellules T surexprimant la GATA-3. L'analyse des cellules infiltrantes a aussi révélé que bien que les cellules EGFP+ étaient présentes dans les poumons suivant la provocation par antigènes, elles étaient constituées seulement d'une petite fraction de cellules CD4+ T recrutées dans les poumons. Ainsi, la GATA-3 amplifie la réaction inflammatoire des poumons induite par antigènes en augmentant l'habileté des cellules T à antigènes spécifiques à recruter
Ali, Asif. « Transcription factors in parathyroid development and embryology ». Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489906.
Texte intégralYoung, Neville Jonathan. « The role of transcription factors in odontogenesis ». Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393692.
Texte intégralFriedrich, Dhana. « Oscillatory transcription factors and stochastic gene expression ». Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/22053.
Texte intégralTranscription factors (TFs) are receiver and compiler of cell signaling, transmitting incoming inputs into cellular responses that enable cells, organs and organisms to respond and adapt to a changing environment. In the past, it has been shown that many TFs exhibit oscillations of nuclear abundance over time when activated. One of these TFs is the tumor suppressor p53, a central hub in the signaling network regulating the cellular stress response, controlling cell fate decisions by changing the expression of hundreds of target genes. Aberrations in p53’s activity are related to severe human malignancies such as cancer. The dynamics of its nuclear accumulation are stimulus dependent and enable the p53 pathway to mediate distinct responses to cellular stress. However, the molecular mechanisms translating such dynamics to altered gene expression remain elusive. In this thesis, I analyzed how oscillations of p53 affect the transcriptional regulation of target genes in single-cells and at individual promoters. I chose a panel of seven targets and employed a combinatorial approach of single-molecule fluorescence in-situ hybridization and mathematical analysis. I present quantitative, time-resolved measurements of target gene mRNA expression and transcriptional bursting activity with single-cell and single-molecule resolution. The resulting data show characteristic principles how p53 nuclear accumulation increases transcriptional bursting upon stimulation and reveal gene-specific modulations. P53 target promoters are regulated by changing the fraction of active promoters, indicating burst frequency regulation. Based on this, genes can be grouped along three archetypes of promoter activity: sustained, transient and pulsatile. These archetypes cannot solely be explained by nuclear p53 levels or promoter binding of total p53. Instead, I provide evidence that the time-varying acetylation state of p53’s C-terminal lysine residues is critical for this gene-specific regulation.
Gillis, William Joseph. « The evolution of metazoan GATA transcription factors / ». Connect to title online (Scholars' Bank) Connect to title online (ProQuest), 2008. http://hdl.handle.net/1794/8568.
Texte intégralTypescript. Includes vita and abstract. "This dissertation includes both ... previously published and unpublished co-authored material"--P. v. Includes bibliographical references (leaves 120-135). Also available online in Scholars' Bank; and in ProQuest, free to University of Oregon users.
Gillis, William Joseph 1981. « The evolution of metazoan GATA transcription factors ». Thesis, University of Oregon, 2008. http://hdl.handle.net/1794/8568.
Texte intégralThis thesis explores the origin and evolution of animal germ layers via evolutionary-developmental analyses of the GATA family of transcription factors. GATA factors identified via a conserved dual zinc-finger domain direct early germ layer specification across a wide variety of animals. However, most of these developmental roles are characterized in invertebrate models, whose rapidly evolved sequences make it difficult to reconstruct evolutionary relationships. This study reconstructs the stepwise evolution of metazoan GATA transcription factors, defining homologous developmental roles based upon clear orthology assignments. We identified two GATA transcription factors ( PdGATA123 and PdGATA456 ) from the marine annelid Platynereis dumerilii to aid comparison of protostome and deuterostome GATA factors. Our phylogenetic analyses defined these as protostome orthologs of GATA1/2/3 and GATA4/5/6 vertebrate subfamilies, while the mRNA localization of the Platynereis GATAs showed ectodermal versus endomesodermal germ layer restrictions, similar to their vertebrate orthologs. To define the phylogenetic relationships of more divergent genes in the invertebrate models, we identified GATA homologs from recently sequenced protostome genomes. Molecular phylogenetic analyses, comparisons of intron/exon structure, and conserved synteny confirm all protostome GATA transcription factor genes are members of either the GATA123 or GATA456 class. These data allowed us to identify multiple protostome-specific duplications of GATA456 homologs and reconstruct the origin and relationships of all arthropod GATA genes. To probe GATA transcription factor evolution in deuterostomes, including vertebrates, we identified GATA factors in basal deuterostomes, including the cephalochordate Branchiostoma floridae and the hemichordate Saccoglossus kowalevskii. Phylogenetic analyses of these data independently confirmed that the ancestral deuterostome and chordate--like the bilaterian ancestor--possessed only two GATA transcription factors. This work was facilitated by a bioinformatics platform we are developing to identify gene families from preassembled genomic sequence. We generated anti- PdGATA antibodies to further explore the role of Platynereis GATAs in germ layer formation. We identified multiple presumptive endomesodermal cells in which nuclear localization of PdGATA456 protein first occurs and utilized PdGATA456 protein localization to follow endomesodermal cell populations throughout development. These analyses represent some of the first cellular and molecular analyses of Platynereis germ layer formation. This dissertation includes both my previously published and unpublished co-authored material.
Adviser: Stephan Q. Schneider
Kiosses, Theodore. « DNA binding specificity and transcriptional regulation of Six4 : a myotonic dystrophy associated transcription factor ». Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3948.
Texte intégralRoberts, Karen. « Regulation of melanocyte-specific transcription by the transcription factors BRN-2 and microphthalmia ». Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286144.
Texte intégralJahangiri, Leila. « Combinatorial gene regulation by T-domain transcription factors ». Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610328.
Texte intégralFerrara, Giovanni Antonio. « Studies of transcriptional regulation by the vitamin D3 receptor and cAMP-responsive transcription factors ». Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69734.
Texte intégralImmarigeon, Clément. « Role of mediator complex subunits in transcriptional regulation by GATA and FOG transcription factors during Drosophila development ». Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2654/.
Texte intégralA major aim of today's research in Biology is to understand how the thousands of genes composing the genome are regulated in order to be expressed in the right cells at the right time. This regulation occurs in large part before gene transcription, at the pre-initiation step. This process results of the concerted action of many proteins, including the large Mediator complex (MED, ~30 protein subunits, >1. 5 MDa), which plays a conserved and crucial role in the regulation of protein-coding genes transcription by RNA polymerase II (PolII), from yeast to humans. This modular complex makes direct core contacts with PolII and general transcription factors, while some subunits can bind to DNA-bound specific transcription factors (TFs). TFs recognize and bind specific regulatory DNA sequences, and drive the tissue-specific expression of their target genes during development. The ubiquitously expressed MED is thought to integrate a cell-specific STF "code" to regulate PolII recruitment and activity at gene promoters. Drosophila melanogaster is a valuable animal model that provides many genetic tools - such as mutant strains and transgenic lines - to address important biological questions in vivo, such as how gene transcription is regulated. A family of TFs, the GATAs, is involved in diverse developmental processes in both Drosophila and vertebrates. They are both activator and repressor TFs, depending on the target gene and the available cofactors, such as Friend Of GATA (FOG) family proteins. The work presented here aimed to understand how GATA TFs use the MED to regulate their target genes both positively and negatively. During the course of this work we generated the first Drosophila mutants for Med1, and investigated the functions of this important subunit in vivo, known as a cofactor of GATAs in vertebrates. We identified a subset of Drosophila MED subunits (including Med1, 12, 13, 15, 19) which are required for proper GATA-dependent processes, such as haematopoiesis, notum morphogenesis and dorso-central (DC) mechanosensory bristle emergence. The last two processes depend on Pannier (Pnr), a GATA-type TF, which directly activates achaete-scute (ac-sc) proneural genes transcription singly, and represses it in presence of its FOG partner U-shaped (Ush). Clonal analysis in vivo showed that Med1, Med15 and Med19, along with Med12/13 subunits of the detachable "CDK8" module of the MED, are critical for ac-sc activation in a cell-autonomous manner, suggesting functional interactions with Pnr. Interestingly, CycC and Cdk8 subunits from CDK8 module are not involved in ac-sc activation, but are required to ensure ac-sc inhibition in surrounding cells, underscoring the diversity of MED subunits functions in vivo. Moreover, we show that Med19 binds physically to Pnr. Thus, Med19 might be the anchor point by which Pnr recruits the MED at Pnr-activated genes. Furthermore, the FOG factor U-shaped inhibits Med19-Pannier interaction by heterodimerizing with Pannier. Thus, the competition for Pnr binding between Med19 (coactivator) and Ush (corepressor) could be responsible for the antagonistic roles of Pnr on the transcription of its target genes. Interestingly, Med19 is also required for transactivation by another GATA factor: Serpent (Srp, cf. Gobert et al. , 2010). Here we show that Med19 also interacts physically with Srp, suggesting that Med19 could be a general cofactor of GATAs in drosophila. On the other hand, Med1 showed no affinity for Drosophila GATAs (contrary to vertebrate Med1), raising questions about the way MED-TF interactions are acquired and maintained, or not, during evolution. This work highlights the interplay between Med19, GATA-Pnr and FOG-Ush, allowing a mechanistic understanding of Pnr actions as both an activator and a repressor of gene transcription. This PhD thesis is an important step towards appreciating how combinatorial codes of TFs are integrated by the MED to regulate gene transcription during development
Ranish, Jeffrey A. « Mechanisms of transcription by RNA Polymerase II / ». Thesis, Connect to this title online ; UW restricted, 1999. http://hdl.handle.net/1773/5057.
Texte intégralYang, Shu, et 杨澍. « Co-evolution of transcription factors and their binding sites ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46339863.
Texte intégralVaidya, Harsh Jayeshkumar. « Investigation of transcriptional regulation of Foxn1 in fetal thymic epithelial progenitor cells ». Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/21697.
Texte intégralSites, Emily. « Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1 ». University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241.
Texte intégralSheffield, Kimberly Kay. « Interplay of Transcription Factor E and Spt4/5 During Transcription Initiation in Pyrococcus furiosus ». PDXScholar, 2018. https://pdxscholar.library.pdx.edu/open_access_etds/4444.
Texte intégral何明孝 et Ming-how Ho. « Sequence variation and covariation in forkhead domains ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970552.
Texte intégralHo, Ming-how. « Sequence variation and covariation in forkhead domains ». Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25155283.
Texte intégralPang, Ting-kai Ronald. « Transcriptional regulation of the human secretin receptor gene / ». Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25059324.
Texte intégralZhou, Shengli. « ZNF451 is a novel binding partner of the bHLH transcription factor E₁₂ ». Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1225219996.
Texte intégral"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: pages 49-62.
Viart, Victoria. « Etude de la régulation transcriptionnelle et post-transcriptionnelle du gène CFTR : identification de facteurs de transcription et de microARNs ». Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T031/document.
Texte intégralCFTR gene, involved in cystic fibrosis, displays a tightly regulated spatio-temporal pattern of expression (mainly expressed in taget tissues of cystic fibrosis). In lung, CFTR transcripts are abundant during fetal development compared to the adult stage (75:1), where only two copies per cell are detected. The aim of this work was to determine the molecular mechanisms involved in this regulation. We have identified several cis-regulatory motifs in the 5'UTR and the 3'UTR parts. We have characterized transcription factors with tissue- and temporal-specific activity. Members of FOX family are crucial regulators in reproductive duct and lung formation. We have also identified microRNAs in destabilizing CFTR transcripts. Finally, we propose a coupling role of trans-acting regulators in the transcriptional and post-transcriptional regulation of the CFTR gene. Characterizing the repressors would help to identify novel therapeutic tools in cystic fibrosis
Towers, Terri L. « Vitamin D3-mediated transcriptional repression : of the granulocyte-macrophage colony stimulating factor gene / ». Access full-text from WCMC, 1998. http://proquest.umi.com/pqdweb?did=733066141&sid=3&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Texte intégral