Thèses : « TPM APPROACH »

1

Gallesi-Torres, A., A. Velarde-Cabrera, C. León-Chavarri, C. Raymundo-Ibañez et F. Dominguez. « Maintenance Management Model under the TPM approach to Reduce Machine Breakdowns in Peruvian Giant Squid Processing SMEs ». Institute of Physics Publishing, 2020. http://hdl.handle.net/10757/656396.

Texte intégral

Résumé :

In recent years, the giant squid processing industry in Peru exhibited a 59% increase in exports with respect to 2018. According to estimates, this industry generates approximately 30,900 jobs per year. However, some SMEs experience low productivity, such as the PECEPE company, due to plant downtime. This represents 26% of the available time, which translates into the loss of 1760 tons every year. The most constraining external factor the sector faces is uncertainty in resource availability caused by changing weather conditions and informal fishing activities. Although there is a large number of research studies on the fishing industry and resource extraction, literature on processing plant operations is scarce. Within this context, this study seeks to promote a high impact sector in Peru, as well as fostering processing plant competitiveness and productivity. Hence, to address these issues, the authors propose a maintenance management model under the TPM approach. As part of the results from model implementation, a 39% decrease was reported in plant downtime, while maintenance costs also decreased by 16%, which, in turn, increased machine availability and production by 784 tons per year.

Styles APA, Harvard, Vancouver, ISO, etc.

2

de, Jongh Leigh-Anne. « The molecular precursor approach to control the morphology of Co₃O₄ on support materials ». Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2539.

Texte intégral

Résumé :

In this project, the TMP method was employed to produce “active sites.” These active sites are for influencing and controlling the Co₃O₄ growth. One of the aims was to investigate what effect the grafting of the molecular precursor has on the nature and distribution of active sites on the various support materials. The second aim was to investigate the effect an increase in molecular precursor loading, in various impregnation steps, has on the nature and distribution of the active sites. The third aim was to investigate the effect of the steric constraints of ligand groups, by changing the molecular precursor, on the nature and distribution of active sites. The fourth aim was to use the different aspects discussed above and apply them to investigate what effect the above-mentioned modifications have on Co₃O₄ morphology. While another aim was to investigated what effect varying the quantity of Co(NO₃)₂•6H₂O has on Co₃O₄ morphology. Lastly, we investigated what effect varying the impregnation procedure and calcination temperature have on the Co₃O₄ morphology. The effect the support has on the phase of titanium molecular precursor was investigated using molecular precursor, ⁱPrOTi[OSi(O[superscript(t)]Bu₃)]₃. The supports used were Silica 922, NanoDur, Aerosil 200, Stöber spherical silica, SBA-15, mod MCM-41 and sMCM-41. The molecular precursor ⁱPrOTi[OSi(O[superscript(t)]Bu₃)]₃ was revealed to be in the orthorhombic TiO₂ with space group P(cab), normal brookite lattice, on Silica 922 after calcination but only an isolated area displaying this morphology. Generally we do not observe any TiO₂ on the support, which indicates that we have produce site-isolated sites, suggesting the TMP method has been successful on all of the various supports. The emphasis is placed on the effect of this molecular precursor and the respective support has on the Co₃O₄ morphology in Chapter 3. In this Chapter, a unique morphology was observed on Silica 922 which showed Co₃O₄ nanorods of cubic Co₃O₄ in the space group Fd-3m. Silica 922 was used for the remainder of the thesis to investigate the effect the quantity of molecular precursor has on the nature of active sites and Co₃O₄ morphology in Chapter 4. This support was also used to investigate the effect the amount of Co(NO₃)₂•6H₂O has on Co₃O₄ morphology in Chapter 5. This support was lastly used to investigate the steric constraints of the ligand groups, Ti[OSi(O[superscript(t)]Bu)₃]₄ (TiSi4), ⁱPrOTi[OSi(O[superscript(t)]Bu)₃]₃ (TiSi3), (OtBu)₃TiOSi(O[superscript(t)]Bu)₃ (TiSi) and the least sterically constrained Ti(OⁱPr)₄ has on the loading of precursor and Co₃O₄ morphology in Chapter 6.

Styles APA, Harvard, Vancouver, ISO, etc.

3

Holden, Martin Lee Castleberry Marion. « A director's approach to Tom Stoppard's Rosencrantz & ; Guildenstern are dead ». Waco, Tex. : Baylor University, 2007. http://hdl.handle.net/2104/5064.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

4

Ceccaldi-Allian, Valérie. « Dynamique d'émergence d'une stratégie d'innovation en TPE : le cas d'une petite cave coopérative vinicole ». Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20155/document.

Texte intégral

Résumé :

Maintenir durablement une activité pendant vingt-trois ans ne s'improvise pas, mais demande au contraire de savoir modeler ensemble pensée et action, contrôle et apprentissage, stabilité et changement. L'élaboration d'une stratégie, par une TPE, suit un processus qui lui est propre c'est-à-dire adapté à ses capacités technologiques et organisationnelles mais aussi lié aux opportunités que son dirigeant arrive à saisir. A l'aide de l'étude du cas d'une petite cave coopérative, nous proposons d'illustrer le processus d'élaboration d'une stratégie. Nous retenons comme fil conducteur le dirigeant qui a occupé à la fois la présidence du conseil d'administration de la coopérative et la direction managériale de la petite firme. Nous verrons que cette originalité fonctionnelle a permis à l'organisation de conjuguer innovation et pérennité sur l'ensemble de ses domaines d'activités, l'autorisant ainsi à poursuivre le développement de son industrie vitivinicole et ce malgré les problématiques fonctionnelles rencontrées ou les évolutions sur son marché. Analyser « l'innovation en train de se faire » a fait émerger l'un après l'autre les évènements-clés qui ont façonné la politique menée de 1988 à 2011 et a permis de mettre en évidence le rôle des acteurs au cœur du processus d'apprentissage stratégique
To maintain durably an activity during twenty-three years doesn't act as itself but it takes to know how to model together : though and action, control and learning, stability and change. The elaboration of a strategy, by a SME, follows a process of its own that is adapted to its technological and organizationel capacities but it must also be connected to the opportunities seized by the manager.Based one's argument on the case study of a small cooperative cellar, we illustrate the elaboration process of a strategy. We retain the story line of the manager who served as chairman of the board of directors of the cooperative and also as managing director of this small firm. We shall see that this functional originality allowed the organization to combine innovation and sustainability on all fields of activity. This helped it to continue the development of its wine industry, in spite of the functional problems or the evolutions of his Market.To study "the innovation being made" has brought to the foreground one after the other the events-keys, which shaped the corporate policy led from 1988 to 2011, and allowed to highlight the role of the actors at the heart of the process of strategic Learning

Styles APA, Harvard, Vancouver, ISO, etc.

5

Akofio, Sowah Margaret Avis Naa Anyeley. « A conceptual framework and approach for enhancing transportation asset management (TAM) implementation for sustained TAM programs ». Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53936.

Texte intégral

Résumé :

In 2012, federal legislation introduced a requirement for formal transportation asset management (TAM) in transportation agencies. The law specifically requires agencies to develop TAM plans and implement TAM programs in their decision-making processes. The history of national policy development for (TAM) and research in policy implementation and organizational theory have shown that program sustainment is not easily achieved. Often, agencies can respond to this kind of legislative mandate with ineffective efforts to achieve legitimacy that reduce the likelihood for the program to be sustained in the long-term. This presents a challenge because without sustainment, the benefits of TAM, which are mostly long-term, may not be fully realized. The objective of this work was to develop a conceptual framework to guide transportation agencies to review their TAM implementation practices and identify opportunities to enhance long-term program sustainment. The conceptual basis for the framework comes from a synthesis of transportation, policy and program implementation, and change management literature, supported by insight from a panel of practitioner and academic experts. The TAM Implementation Review Framework (TIRF) incorporates seven themes of implementation factors that can promote sustainment of TAM practices impacting the social, organizational, and programmatic elements of implementation. The TIRF was applied in case studies to review the TAM implementation processes of three Departments of Transportation (DOTs) resulting in different kinds of information on how implementation activities address factors related to program sustainment. These results can steer future implementation activities in DOTs towards increased probabilities of achieving long-term program sustainment. The primary contributions of this work lie in the development of the conceptual framework and approach to enhance TAM implementation by emphasizing the people and organizational elements of TAM, alongside with the technical. In practice, the TIRF offers agencies a review and planning tool to support TAM implementation decision making and to promote program sustainment. The output is being proposed as a foundational element in the development of an evidence-based catalog of TAM implementation strategies. This can facilitate inter-agency knowledge sharing by providing a platform for systematic documentation of implementation experiences to support broader adoption of strategies that can contribute to increased program sustainment.

Styles APA, Harvard, Vancouver, ISO, etc.

6

Wentzel, John Peter. « Modelling financial services adoption through an intermediary in South Africa : TAM and SEM approach ». Thesis, University of Pretoria, 2012. http://hdl.handle.net/2263/25926.

Texte intégral

Résumé :

One of the most pressing needs society has in 2012 is addressing the plight of the 4 billion people, globally, who live at the bottom of the economic pyramid. Unless initiatives are undertaken to alleviate poverty and hardship in this portion of society, human potential will be wasted and the economic burden on the rest of society to support them will remain significant. In South Africa a significant portion of the population live at the bottom of the pyramid. One initiative to alleviate poverty and hardship is to enable bottom of the pyramid people who are excluded from formal financial services to access to them. By accessing formal financial services they would be able to safely save and borrow money. They would also be able to escape exploitative informal financial practices. Technology has the potential to expand access to financial services and reduce the cost of service provision. To date, however, it has not delivered on its promise of expanding financial inclusion at the bottom of the pyramid. Intermediaries, too, have been used to increase access to financial services but have also not successfully expanded financial inclusion at the bottom of the pyramid. Understanding which factors would allow these approaches to realize their potential has the ability to meaningfully contribute to addressing the plight of people at the bottom of the pyramid. This study brings together the potential of technology and the role of intermediaries to model expanding financial inclusion at the bottom of the pyramid in South Africa. The Technology Acceptance Model is used as a basis to propose an extended TAM model that explains adoption of technology enabled financial services through an intermediary at the bottom of the pyramid in South Africa. The proposed model is validated using structural equation modelling with data collected in a national survey in South Africa. The extended TAM model successfully explains more than 90% of the behavioural intention of financially excluded people at the bottom of the pyramid to adopt financial services through an intermediary. Using the findings, a strategic approach to expanding financial inclusion at the bottom of the pyramid is proposed.
Thesis (PhD(Eng))--University of Pretoria, 2012.
Industrial and Systems Engineering
unrestricted

Styles APA, Harvard, Vancouver, ISO, etc.

7

Poppleton-Pritchard, Rosalind. « A crisis 'in country' : an ecocritical approach to Tim O'Brien's fiction ». Thesis, University of Hertfordshire, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323457.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

8

Senger, Pia, et Esra Özülkü. « German Generation Y’s PurchaseIntention towards Packaging-Free Products : A TPB Approach ». Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Företagsekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39559.

Texte intégral

Résumé :

Background: The problem of increasing amounts of food packaging waste especially in Germany leads to the challenge of how to minor waste by using no packaging in order to listen to environmental-conscious generation y consumers. This is why retailers need to understand the factors impacting the purchase intention and thus, need to act in higher extend in terms of a preventive sustainable approach. Purpose: The purpose of this thesis is to examine the purchase intention of German generation y consumers towards packaging-free products. An extended Theory of Planned Behavior forms the theoretical foundation to investigate which factors are influencing the purchase intention the most. In addition to the original TPB factors attitude, subjective norms and perceived behavioral control, the research model was extended by two new factors, namely environmental concern and barriers. Method: Through an explanatory research method, the data was collected in a quantitative online survey based on a sample of 422 respondents. In order to investigate the relationships among the factors and to further support or reject the study’s hypothesis, the data was analyzedby using descriptive statistics, Pearson correlation and simple and multiple regression. Finally, to determine differences among groups additional tests have been conducted. Conclusion: The findings of this study revealed new insights about predictors of the purchaseintention: German consumers’ intention is mainly impacted by their attitude, followed by thefactor barriers, and perceived behavioral control, whereas subjective norms do not. Further, the other newly added factor environmental concern indirectly impacts the purchase intention through attitude. Moreover, the importance of including new added factors to the original TPB model is shown as the extended TPB model has improved its power in explaining German generation y’s purchase intention towards packaging free. By that, the respondents of this studyare highly environmental concerned and overall intent to purchase packaging-free products in mainstream grocery stores, oats and milk respectively. This study’s results provide valuable insights for marketers of German mainstream grocery stores who are interested in selectively integrating packaging-free shopping to their stores.

Styles APA, Harvard, Vancouver, ISO, etc.

9

Banerjee, D., P. Dhara, K. Chatterjee, K. Kargupta et S. Ganguly. « Thermoelectric Characterization of Nanostructures of Bismuth Prepared by Solvothermal Approach ». Thesis, Sumy State University, 2012. http://essuir.sumdu.edu.ua/handle/123456789/35251.

Texte intégral

Résumé :

Nanostructured thermoelectric materials being an emerging area of research bismuth (Bi) nanostructures have been developed by solvothermal approach with a change of solvent. Structural characterization revealed that nanorods and nanospheres like structures were generated in the process when the solvent used were only ethylene glycol (EG) and ethylene glycol with absolute ethanol (AE) in the ratio of 1:1 respectively. Electrical properties viz. conductivity (σ) and thermoelectric power(S) have been measured in the temperature range 300K to 400K. From the observed value of σ and S power factor P has been calculated. The property improved for nanosphere like structures. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35251

Styles APA, Harvard, Vancouver, ISO, etc.

10

Beltrán, Ramirez Jhosep Victorino. « On equivalence of scalar quantum electrodynamics via Duffin-Kemmer-Petiau and Klein-Gordon-Fock formalism using causal perturbation theory approach ». Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153869.

Texte intégral

Résumé :

Submitted by Jhosep Victorino Beltrán Ramirez (jhosep@ift.unesp.br) on 2018-04-30T23:53:58Z No. of bitstreams: 1 Thesis final version.pdf: 1232865 bytes, checksum: 9c45a7f2b11fb5626fc2289be640684d (MD5)
Rejected by Hellen Sayuri Sato null (hellen@ift.unesp.br), reason: Solicitamos que realize correções na submissão seguindo as orientações abaixo - Incluir Resumo no PDF Agradecemos a compreensão on 2018-05-02T17:34:18Z (GMT)
Submitted by Jhosep Victorino Beltrán Ramirez (jhosep@ift.unesp.br) on 2018-05-03T02:49:03Z No. of bitstreams: 1 TesisDKP.pdf: 952544 bytes, checksum: 7ba12d74da05e9e6a1834ff32937078d (MD5)
Rejected by Hellen Sayuri Sato null (hellen@ift.unesp.br), reason: Solicitamos que realize correções na submissão seguindo as orientações abaixo: - incluir palavras-chave no PDF após o resumo - incluir Key words no PDF após o abstract Agradecemos a compreensão on 2018-05-03T17:25:11Z (GMT)
Submitted by Jhosep Victorino Beltrán Ramirez (jhosep@ift.unesp.br) on 2018-05-04T01:04:35Z No. of bitstreams: 1 TesisDKP.pdf: 952865 bytes, checksum: 283f93ab15503686eccf06947a681380 (MD5)
Approved for entry into archive by Hellen Sayuri Sato null (hellen@ift.unesp.br) on 2018-05-04T18:33:41Z (GMT) No. of bitstreams: 1 beltranramirez_jv_dr_ift.pdf: 952865 bytes, checksum: 283f93ab15503686eccf06947a681380 (MD5)
Made available in DSpace on 2018-05-04T18:33:41Z (GMT). No. of bitstreams: 1 beltranramirez_jv_dr_ift.pdf: 952865 bytes, checksum: 283f93ab15503686eccf06947a681380 (MD5) Previous issue date: 2018-03-02
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Nesta tese utilizamos a teoria de perturbação causal para estudar a eletrodinâmica quântica escalar com os campos de Duffin-Kemmer-Petiau. Determinamos as seções de choque diferenciais no nível da árvore, o tensor de polarização do vácuo, a função de auto energia e a renormalizabilidade da teoria. Depois disso, comparamos nossos resultados com os obtidos através dos campos de Klein-Gordon-Fock, determinando que eles não são completamente equivalentes
In this Thesis we use causal perturbation theory to study scalar quantum electrodynamics with Du n-Kemmer-Petiau elds. We determine the differential cross sections at the tree level, the vacuum polarization tensor, self energy function and the normalizability of the theory. After that, we compare our results with those ones obtained via Klein-Gordon-Fock elds determining that they are not completely equivalenttf

Styles APA, Harvard, Vancouver, ISO, etc.

11

Shaw, Deirdre. « Consumed by ethics ? : a model building approach to ethical consumer decision-making ». Thesis, Glasgow Caledonian University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311798.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

12

Schüler, Malte [Verfasser], Tim [Akademischer Betreuer] [Gutachter] Wehling et Gerd [Gutachter] Czycholl. « Theoretical approaches to realistic strongly correlated nanosystems / Malte Schüler. Betreuer : Tim Wehling. Gutachter : Tim Wehling ; Gerd Czycholl ». Bremen : Staats- und Universitätsbibliothek Bremen, 2016. http://d-nb.info/1112648224/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

13

Watene, Krushil P. M. « Strengthening the capability approach : the foundations of the capability approach, with insights from two challenges ». Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1902.

Texte intégral

Résumé :

The Capability Approach was initially developed by Nobel laureate Amartya Sen, with the first basic articulation presented in his 1979 ‘Equality of What?’ Tanner Lecture. Since then, the approach has gained a huge amount of attention as a conceptual framework which offers a clear and insightful way to measure well-being and development. Most recently, the approach has been refined and extended by Martha Nussbaum to issues of disability, nationality, and species membership in political philosophy. This project is about the foundations of the capability approach. More specifically, this project asks whether we can, and whether there are good reasons to, strengthen those foundations. The conclusions drawn here are that we ought to think seriously about the way that the capability approach develops as a theory that responds to real world challenges and change. More importantly, this project contends – in light of the challenges of future people and indigenous peoples – that there is good reason to think of new ways to ground the approach. This project takes up this challenge and grounds the approach in a modified version of Tim Mulgan’s approach to well-being. This project demonstrates that this alternative enriches the capability approach by providing us with a way of making sense of important problems, and with options for moving forward. Overall, this project asks important questions about how the capability approach could evolve based on challenges that remain relatively under-explored in the current literature. This project contributes to this literature by demonstrating that we can and ought to strengthen the capability approach and its ability to understand, take on board, and resolve these challenges.

Styles APA, Harvard, Vancouver, ISO, etc.

14

Pang, Jinbo. « Thermal deposition approaches for graphene growth over various substrates ». Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-220794.

Texte intégral

Résumé :

In the course of the PhD thesis large area homogeneous strictly monolayer graphene films were successfully synthesized with chemical vapor deposition over both Cu and Si (with surface oxide) substrates. These synthetic graphene films were characterized with thorough microscopic and spectrometric tools and also in terms of electrical device performance. Graphene growth with a simple chemo thermal route was also explored for understanding the growth mechanisms. The formation of homogeneous graphene film over Cu requires a clean substrate. For this reason, a study has been conducted to determine the extent to which various pre-treatments may be used to clean the substrate. Four type of pre-treatments on Cu substrates are investigated, including wiping with organic solvents, etching with ferric chloride solution, annealing in air for oxidation, and air annealing with post hydrogen reduction. Of all the pretreatments, air oxidation with post hydrogen annealing is found to be most efficient at cleaning surface contaminants and thus allowing for the formation of large area homogeneous strictly monolayer graphene film over Cu substrate. Chemical vapor deposition is the most generally used method for graphene mass production and integration. There is also interest in growing graphene directly from organic molecular adsorbents on a substrate. Few studies exist. These procedures require multiple step reactions, and the graphene quality is limited due to small grain sizes. Therefore, a significantly simple route has been demonstrated. This involves organic solvent molecules adsorbed on a Cu surface, which is then annealed in a hydrogen atmosphere in order to ensure direct formation of graphene on a clean Cu substrate. The influence of temperature, pressure and gas flow rate on the one-step chemo thermal synthesis route has been investigated systematically. The temperature-dependent study provides an insight into the growth kinetics, and supplies thermodynamic information such as the activation energy, Ea, for graphene synthesis from acetone, isopropanol and ethanol. Also, these studies highlight the role of hydrogen radicals for graphene formation. In addition, an improved understanding of the role of hydrogen is also provided in terms of graphene formation from adsorbed organic solvents (e.g., in comparison to conventional thermal chemical vapor deposition). Graphene synthesis with chemical vapor deposition directly over Si wafer with surface oxide (Si/SiOx ) has proven challenging in terms of large area and uniform layer number. The direct growth of graphene over Si/SiO x substrate becomes attractive because it is free of an undesirable transfer procedure, necessity for synthesis over metal substrate, which causes breakage, contamination and time consumption. To obtain homogeneous graphene growth, a local equilibrium chemical environment has been established with a facile confinement CVD approach, inwhich two Si wafers with their oxide faces in contact to form uniform monolayer graphene. A thorough examination of the material reveals it comprises facetted grains despite initially nucleating as round islands. Upon clustering these grains facet to minimize their energy, which leads to faceting in polygonal forms because the system tends to ideally form hexagons (the lowest energy form). This is much like the hexagonal cells in a beehive honeycomb which require the minimum wax. This process also results in a near minimal total grain boundary length per unit area. This fact, along with the high quality of the resultant graphene is reflected in its electrical performance which is highly comparable with graphene formed over other substrates, including Cu. In addition the graphene growth is self-terminating, which enables the wide parameter window for easy control. This chemical vapor deposition approach is easily scalable and will make graphene formation directly on Si wafers competitive against that from metal substrates which suffer from transfer. Moreover, this growth path shall be applicable for direct synthesis of other two dimensional materials and their Van der Waals hetero-structures
Im Zuge dieser Doktorarbeit wurden großflächige und homogene Graphen-Monolagen mittels chemischer Gasphasenabscheidung auf Kupfer- (Cu) und Silizium-(Si) Substraten erfolgreich synthetisiert. Solche monolagigen Graphenschichten wurden mithilfe mikroskopischer und spektrometrischer Methoden gründlich charakterisiert. Außerdem wurde der Wachstumsmechanismus von Graphen anhand eines chemo-thermischen Verfahrens untersucht. Die Bildung von homogenen Graphenschichten auf Cu erfordert eine sehr saubere Substratoberfläche, weshalb verschiedene Substratvorbehandlungen und dessen Einfluss auf die Substratoberfläche angestellt wurden. Vier Vorbehandlungsarten von Cu-Substraten wurden untersucht: Abwischen mit organischen Lösungsmitteln, Atzen mit Eisen-(III)-Chloridlösung, Wärmebehandlung an Luft zur Erzeugung von Cu-Oxiden und Wärmebehandlung an Luft mit anschließender Wasserstoffreduktion. Von diesen Vorbehandlungen ist die zuletzt genannte Methode für die anschließende Abscheidung einer großflächigen Graphen-Mono-lage am effektivsten. Die chemische Gasphasenabscheidung ist die am meisten verwendete Methode zur Massenproduktion von Graphen. Es besteht aber auch Interesse an alternativen Methoden, die Graphen direkt aus organischen, auf einem Substrat adsorbierten Molekülen, synthetisieren konnen. Jedoch gibt es derzeit nur wenige Studien zu derartigen alternativen Methoden. Solche Prozessrouten erfordern mehrstufige Reaktionen, welche wiederrum die Qualität der erzeugten Graphenschicht limitieren, da nur kleine Korngrößen erreicht werden konnen. Daher wurde in dieser Arbeit ein deutlich einfacherer Weg entwickelt. Es handelt sich dabei um ein Verfahren, bei dem auf einer Cu-Substratoberfläche adsorbierte, organische Lösungsmittelmoleküle in einer Wasserstoffatmosphäre geglüht werden, um eine direkte Bildung von Graphen auf einem sauberen Cu-Substrat zu gewahrleisten.Der Einfluss von Temperatur, Druck und Gasfluss auf diesen einstufigen chemothermischen Syntheseweg wurde systematisch untersucht. Die temperaturabhängigen Untersuchungen liefern einen Einblick in die Wachstumskinetik und thermodynamische Größen, wie zum Beispiel die Aktivierungsenergie Ea, für die Synthese von Graphen aus Aceton, Isopropanol oder Ethanol. Diese Studien untersuchen außerdem die Rolle von Wasserstoffradikalen auf die Graphensynthese. Weiterhin wurde ein verbessertes Verständnis der Rolle von Wasserstoff auf die Graphen-synthese aus adsorbierten, organischen Lösungsmitteln erlangt (beispielsweise im Vergleich zur konventionellen thermischen Gasphasenabscheidung). Die direkte Graphensynthese mittels chemischer Gasphasenabscheidung auf Si-Substraten mit einer Oxidschicht (Si/SiOx ) ist extrem anspruchsvoll in Bezug auf die großflächige und einheitliche Abscheidung (Lagenanzahl) von Graphen-Monolagen. Das direkte Wachstum von Graphen auf Si/SiOx -Substrat ist interessant, da es frei von unerwünschten Übertragungsverfahren ist und kein Metall-substrat erfordert, welche die erzeugten Graphenschichten brechen lassen können. Um ein homogenes Graphenwachstum zu erzielen wurde durch den Kontakt zweier Si-Wafer, mit ihren Oxidflachen zueinander zeigend, eine lokale Umgebung im chemischen Gleichgewicht erzeugt. Diese Konfiguration der Si-Wafer ist nötig, um eine einheitliche Graphen-Monolage bilden zu können. Eine gründliche Untersuchung des abgeschiedenen Materials zeigt, dass trotz der anfänglichen Keimbildung von runden Inseln facettierte Körner erzeugt werden. Aufgrund der Bestrebung der Graphenkörner ihre (Oberflächen-) Energie zu minimieren, wird eine Facettierung der Körner in polygonaler Form erzeugt, was darin begründet liegt, dass das System idealerweise eine Anordnung von hexagonal geformten Körnern erzeugen würde (niedrigster Energiezustand). Der Prozess ist vergleichbar mit der sechseckigen Zellstruktur einer Bienenstockwabe, welche ein Minimum an Wachs erfordert. Dieser Prozess führt auch zu einer nahezu minimalen Gesamtkorn-grenzlänge pro Flächeneinheit. Diese Tatsache zusammen mit der hohen Qualität der resultierenden Graphenschicht spiegelt sich auch in dessen elektrischer Leistungsfähigkeit wider, die in hohem Maße mit der auf anderen Substraten gebildeten Graphenschichten (inklusive Cu-Substrate) vergleichbar ist. Darüber hinaus ist das Graphenwachstum selbstabschliessend, wodurch ein großes Parameterfenster für eine einfache und kontrollierte Synthese eröffnet wird. Dieser Ansatz zur chemischen Gasphasenabscheidung von Graphen auf Si- Substraten ist leicht skalierbar und gegenüber der Abscheidung auf Metallsubstraten konkurrenzfähig, da keine Substratübertragung notig ist. Darüber hinaus ist dieser Prozess auch für die direkte Synthese anderer zweidimensionalen Materialien und deren Van-der-Waals-Heterostrukturen anwendbar

Styles APA, Harvard, Vancouver, ISO, etc.

15

Alexandru, Mihai. « Efficient large electromagnetic simulation based on hybrid TLM and modal approach on grid computing and supercomputer ». Phd thesis, Institut National Polytechnique de Toulouse - INPT, 2012. http://tel.archives-ouvertes.fr/tel-00797061.

Texte intégral

Résumé :

Dans le contexte des Sciences de l'Information et de la Technologie, un des challenges est de créer des systèmes de plus en plus petits embarquant de plus en plus d'intelligence au niveau matériel et logiciel avec des architectures communicantes de plus en plus complexes. Ceci nécessite des méthodologies robustes de conception afin de réduire le cycle de développement et la phase de prototypage. Ainsi, la conception et l'optimisation de la couche physique de communication est primordiale. La complexité de ces systèmes rend difficile leur optimisation notamment à cause de l'explosion du nombre des paramètres inconnus. Les méthodes et outils développés ces dernières années seront à terme inadéquats pour traiter les problèmes qui nous attendent. Par exemple, la propagation des ondes dans une cabine d'avion à partir des capteurs ou même d'une antenne, vers le poste de pilotage est grandement affectée par la présence de la structure métallique des sièges à l'intérieur de la cabine, voir les passagers. Il faut, donc, absolument prendre en compte cette perturbation pour prédire correctement le bilan de puissance entre l'antenne et un possible récepteur. Ces travaux de recherche portent sur les aspects théoriques et de mise en oeuvre pratique afin de proposer des outils informatiques pour le calcul rigoureux de la réflexion des champs électromagnétiques à l'intérieur de très grandes structures . Ce calcul implique la solution numérique de très grands systèmes inaccessibles par des ressources traditionnelles. La solution sera basée sur une grille de calcul et un supercalculateur. La modélisation électromagnétique des structures surdimensionnées par plusieurs méthodes numériques utilisant des nouvelles ressources informatiques, hardware et software, pour dérouler des calculs performants, représente le but de ce travail. La modélisation numérique est basée sur une approche hybride qui combine la méthode Transmission-Line Matrix (TLM) et l'approche modale. La TLM est appliquée aux volumes homogènes, tandis que l'approche modale est utilisée pour décrire les structures planaires complexes. Afin d'accélérer la simulation, une implémentation parallèle de l'algorithme TLM dans le contexte du paradigme de calcul distribué est proposé. Le sous-domaine de la structure qui est discrétisé avec la TLM est divisé en plusieurs parties appelées tâches, chacune étant calculée en parallèle par des processeurs différents. Pour accomplir le travail, les tâches communiquent entre elles au cours de la simulation par une librairie d'échange de messages. Une extension de l'approche modale avec plusieurs modes différents a été développée par l'augmentation de la complexité des structures planaires. Les résultats démontrent les avantages de la grille de calcul combinée avec l'approche hybride pour résoudre des grandes structures électriques, en faisant correspondre la taille du problème avec le nombre de ressources de calcul utilisées. L'étude met en évidence le rôle du schéma de parallélisation, cluster versus grille, par rapport à la taille du problème et à sa répartition. En outre, un modèle de prédiction a été développé pour déterminer les performances du calcul sur la grille, basé sur une approche hybride qui combine une prédiction issue d'un historique d'expériences avec une prédiction dérivée du profil de l'application. Les valeurs prédites sont en bon accord avec les valeurs mesurées. L'analyse des performances de simulation a permis d'extraire des règles pratiques pour l'estimation des ressources nécessaires pour un problème donné. En utilisant tous ces outils, la propagation du champ électromagnétique à l'intérieur d'une structure surdimensionnée complexe, telle qu'une cabine d'avion, a été effectuée sur la grille et également sur le supercalculateur. Les avantages et les inconvénients des deux environnements sont discutés.

Styles APA, Harvard, Vancouver, ISO, etc.

16

Li, Han. « Transfer Matrix Approach to Propagation of Angular Plane Wave Spectra Through Metamaterial Multilayer Structures ». University of Dayton / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1324508726.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

17

Lainé, Annick. « Management coopératif et gouvernance coopérative : un trait d'union pour un développement soutenable des SCOP : analyse des pratiques de SCOP TPE-PME en Rhône Alpes ». Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON10047.

Texte intégral

Résumé :

Ce travail de recherche doctoral a pour objet l'étude des relations entre la Gouvernance, le Management des Ressources Humaines et la Stratégie des SCOP. Ces entreprises coopératives, au projet politique originel et original, s'organisent à partir de valeurs issues du XIX ème siècle que sont la solidarité, la propriété collective inter-générationnelle et l'équité, eu égard à leur triple filiation économique, politique et sociale.L'identification de risques de tensions et d'éclatements inhérents à ce type de gouvernance hybride fait appel à un management adapté pour animer une organisation de salarié-e-s -associé-e-s majoritaires en co-responsabilité d'une organisation coopérative.Cette problématique à la croisée du terrain et de la littérature, s'inscrit dans une démarche innovante d'approche triptyque pour une méthodologie qualitative.L'analyse des pratiques et des discours recueillis auprès de gérant-e-s de 16 SCOP TPE PME de Rhône Alpes et d'animateurs du secteur coopératif a révélé d'une part des freins et des leviers et d'autre part des éléments de contingence au Développement Coopératif Soutenable des SCOP. Ces résultats ont permis l'élaboration d'un idéal type de Management Coopératif et de Développement Coopératif Soutenable complétés par le SCCORRET et la pyramide de l'équilibre coopératif, outils de gestion coopératifs proposés pour prévenir les risques de tensions individuels et collectifs et l'établissement du lien existant entre Gouvernance Coopérative-Management Coopératif et Développement Coopératif
This doctoral research aims to study the relationship between Governance, Human Resource Management and Strategy of SCOP. These co-operative enterprises have an original and innovative political project and are beneficiaries of a triple linage of economic, political & social nature. Their values which derived from the nineteenth century are of solidarity, collective inter-generational ownership and equity.The identification of risks of tension and disintegration inherent to such an hybrid form of governance calls for a adequate management to run a co-operative organisation where worker members have a majority vote in co-responsibility.This issue emerging from both the field and the literature is studied in an innovative triptych approach based on a qualitative methodology. The analysis of practices and speeches - gathered from managers of 16 micro co-operatives and small & medium co-operatives of Rhône Alpes and from leaders of the co-operative sector – has revealed, on one hand, brakes and levers and on the other hand, contingency elements to a sustainable co-operative development of SCOP.These results have allowed the development of an ideal type of co-operative management and sustainable co-operative development based on co-operative management tools designed to prevent the risk of individual and collective tensions and to strenghthen the link between co-operative governance, co-operative management and co-operative development

Styles APA, Harvard, Vancouver, ISO, etc.

18

Youmbi, Foka Marcel [Verfasser], Tim [Akademischer Betreuer] Clark, Tim [Gutachter] Clark et Birgit [Gutachter] Strodel. « 3D-QSAR/QSPR Based Surface-Dependent Modeling Approach Derived From Semi-Empirical Quantum Mechanical Calculations / Marcel Youmbi Foka ; Gutachter : Tim Clark, Birgit Strodel ; Betreuer : Tim Clark ». Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2018. http://d-nb.info/1175206490/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

19

Bourguiba, Malek Bayad Mohamed. « De l'intention à l'action entrepreneuriale approche comparative auprès de TPE françaises et tunisiennes / ». S. l. : Université Nancy 2, 2007. http://cyberdoc.univ-nancy2.fr/htdocs/docs_ouvert/doc283/2007NAN22003_1.pdf.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

20

Bourguiba, Malek. « De l'intention à l'action entrepreneuriale : approche comparative auprès de TPE françaises et tunisiennes ». Thesis, Nancy 2, 2007. http://www.theses.fr/2007NAN22003/document.

Texte intégral

Résumé :

Cette thèse est consacrée à l'étude de la contingence culturelle de l'intention-action de création d'entreprise. Elle met en oeuvre une recherche empirique qui permet, au travers de la démarche de triangulation, d'explorer le rôle de la culture nationale dans ces notions. Une analyse théorique des principaux concepts dans le domaine de l'entrepreneuriat et de la culture nationale, permettra de mettre en évidence un cadre conceptuel adapté à l'étude de la contingence culturelle de l'intention entrepreneuriale. En effet, ce dernier propose une approche intégrant les différents niveaux d'analyse de la culture nationale et leurs incidences sur la formation de l'intention entrepreneuriale. La thèse présente son projet en termes de problématique et de méthodologie, au travers d'un processus de collecte de données, par entretiens et questionnaires, sur 35 études de cas de créateurs de TPE en provenance de la région Lorraine (France) et de la région Grand Tunis (Tunisie). Les traitements de ces données (analyses qualitative et quantitative) conduisent à adopter la contingence culturelle de la désirabilité et de la faisabilité perçues de se lancer en affaires. La recherche suggère aux acteurs décideurs que l'intention entrepreneuriale ne peut-être considérée comme universelle. En revanche, elle peut être investie au travers de certaines caractéristiques culturelles spécifiques, notamment les valeurs et croyances culturelles, le contexte relationnel, les motivations, les modèles d'entrepreneurs, etc. Ainsi, cette étude met en avant l'imbrication de la culture nationale et la culture entrepreneuriale
This thesis is dedicated to study a cultural contingency of the entrepreneurial intention-action. It uses empirical research which permits, through a triangulation method, to explore the role of national culture in these notions. A theoretical analysis of main concepts on entrepreneurship and national culture enables to suggest an adapted conceptual framework for studying cultural contingency on entrepreneurial intention. In fact, this framework proposes an approach that permits to integrate different analysis levels of national culture and their effects on the entrepreneurial intention formation. The thesis presents its problematic and methodological project, through interviews and questionnaires applied in 35 case studies of small business creators, coming from "Lorraine" region (France) and "Grand Tunis" region (Tunisia). The data treatment (quantitative and qualitative analysis) brings to adopt the cultural contingency of perceived desirability and feasibility to start a business. The research suggests that intention of business creation can't be considered as universal. On the other hand it can be surrounded according to specific cultural characteristics, particularly, cultural values and beliefs, relational context, motivations, entrepreneurs' roles models, etc. It defends also the imbrication's entrepreneurial and national cultures

Styles APA, Harvard, Vancouver, ISO, etc.

21

Starzmann, Paul Verfasser], Tom [Gutachter] [Güldemann et Wilhelm J. G. [Gutachter] Möhlig. « Inheritance and contact in Central Kenya Bantu : a dialectological approach / Paul Starzmann ; Gutachter : Tom Güldemann, Wilhelm J.G. Möhlig ». Berlin : Kultur-, Sozial- und Bildungswissenschaftliche Fakultät, 2017. http://d-nb.info/1125504250/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

22

Starzmann, Paul [Verfasser], Tom [Gutachter] Güldemann et Wilhelm J. G. [Gutachter] Möhlig. « Inheritance and contact in Central Kenya Bantu : a dialectological approach / Paul Starzmann ; Gutachter : Tom Güldemann, Wilhelm J.G. Möhlig ». Berlin : Kultur-, Sozial- und Bildungswissenschaftliche Fakultät, 2017. http://d-nb.info/1125504250/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

23

Melinte, Georgian. « Advanced 3D and in-situ TEM approaches applied to carbon-based and zeolitic nanomaterials ». Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAE009/document.

Texte intégral

Résumé :

Dans le cadre de cette thèse, des techniques avancées de Microscopie électronique à transmission (MET)ont été utilisées dans le but de caractériser et de fabriquer de nouveaux nanomatériaux pour des applications dans les domaines de la nanoélectronique et de la catalyse. Trois types de matériaux fonctionnalisés sont étudiés: le graphène multifeuillets (FLG– Few-Layer Graphene) avec des nanomotifs,des nanotubes de carbone (CNTs - Carbon Nanotubes en anglais) et des zéolithes mésoporeux. La formation de nanomotifs de tranchées et de tunnels sur des flocons de FLG à l’aide de nanoparticules(NPs) de fer est étudiée dans une approche qui combine la tomographie électronique et la MET environnementale. Le rôle des facettes de la nanoparticule et des paramètres topographiques de FLG a été déterminé du point de vue quantitatif, ce qui a mené à la mise en évidence du mécanisme de formation des nanomotifs de tranchées et de tunnels. Le transfert de nanoparticules à base de métal entre deux nanostructures de carbone a été également étudié, en temps réel, en employant un porte-échantillon MET couplé avec un dispositif STM (Scanning Tunneling Microscope en anglais). Le protocole de contrôle du transfert des nanoparticules, les transformations chimiques et structurales subies par celles-ci, le mécanisme de croissance de nouvelles nanoparticules et d’autres phénomènes liés à ces effets ont été étudiés avec attention. La dernière partie de la thèse est centrée sur l’étude de la tomographie électronique à faible dose de la porosité induite dans deux classes de zéolithes, ZSM-5 et zéolithe Y, en utilisant un traitement chimique novateur à base de fluor
In this thesis, advanced Transmission Electron Microscopy (TEM) techniques are used to characterize and fabricate new nanomaterials with applications in nanoelectronics and catalysis. Three types of functionalized materials are investigated: nanopatterned few-layer graphene (FLG), carbon nanotubes(CNTs) and mesoporous zeolites. The nanopatterning process of FLG flakes by iron nanoparticles (NPs) is studied using an approach combining electron tomography (ET) and environmental TEM. The role of the nanoparticle faceting and of the FLG topographic parameters has been quantitatively determined leading to the first determination of the operating mechanism of the patterning process. The mass transfer of metallic-based NPs between two carbon nanostructures was studied as well in real-time by using a TEMSTMholder. The protocol of controlling the mass transfer, the chemical and structural transformations of the NPs, the growth mechanism of the new NPs and other related phenomena were carefully investigated.The last part deals with the low-dose ET investigation of the porosity induced in two classes of zeolites,ZSM-5 and zeolite Y, by an innovative fluoride-based chemical treatment

Styles APA, Harvard, Vancouver, ISO, etc.

24

Sato, Kaoru. « The development of new TEM approaches for quantification of spinodal decomposition and local segregation ». Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305660.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

25

Maiwald, Tim [Verfasser], et Ursula [Akademischer Betreuer] Kummer. « Computational analysis of the interferon alpha signalling pathway using a systems biology modelling approach / Tim Maiwald ; Betreuer : Ursula Kummer ». Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1179784073/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

26

Schröder, Kristin, et Saskia Pietralla. « Generation y’s intention to perform in-store recycling in the fast fashion industry : A combined TPB and NAM approach ». Thesis, Internationella Handelshögskolan, Högskolan i Jönköping, IHH, Företagsekonomi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39632.

Texte intégral

Résumé :

Background: Due to accelerating environmental problems caused by fast fashion sustainable business solutions become increasingly important. Thus, the following thesis examines generation y’s intention to perform in-store recycling at fast fashion retailers and investigates the factors most influential on intention. Besides, it analyses if an attitude-intention gap exists. To fulfil the study’s purpose, a combination of the theory of planned behaviour (Ajzen, 1985) and the norm activation model (Schwartz, 1977) is used. Approach: Within this study a quantitative method in terms of an online survey is applied. Based on a sample of 326 respondents, relationships between variables are analysed with Pearson correlation analysis and multiple regression. To further identify differences among groups, Independent samples t-test and ANOVA are conducted. Findings: The study’s findings reveal that generation y generally intends to participate in in-store recycling, while the intention is significantly higher among women than men. The intention to perform in-store recycling is predominantly intrinsically motivated as it is most driven by individuals’ personal norm. Value: The findings of our study particularly add value for fast fashion retailers and marketers by presenting a novel research model combining most relevant factors required to adequately address consumers among generation y to perform in-store recycling. This specifically allows fashion retailers to successfully establish the concept of in-store recycling. Our study is further beneficial for sustainability researchers, environmental activists, charity organisations and policy makers to create a more sustainable future.

Styles APA, Harvard, Vancouver, ISO, etc.

27

Ehlers, Tim [Verfasser], Robert [Akademischer Betreuer] [Gutachter] Schwager et Gerhard [Gutachter] Rübel. « Modeling Approaches in Educational Research / Tim Ehlers ; Gutachter : Robert Schwager, Gerhard Rübel ; Betreuer : Robert Schwager ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/1125105798/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

28

Maclean, Jessica Amy Ann. « Novel approaches to enhance the thrombolytic potential of tissue plasminogen activator (tPA) therapy in stroke ». Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23147.

Texte intégral

Résumé :

Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) remains the primary pharmacological therapy for acute ischaemic stroke. Despite some significant clinical benefit at three months, rtPA-mediated recanalisation rates remain suboptimal in over 50% of patients receiving this therapy, and cerebral reperfusion is not always achieved with arterial reopening. The aim of these doctoral studies was to investigate novel adjunctive antithrombotic approaches to enhance rtPA-mediated large artery recanalisation and improve cerebral perfusion in a mouse model of stroke. Initial studies focused on the development of the in situ carotid artery thrombo(ly)sis (iCAT) model, the first mouse model of electrolytic-induced carotid artery thrombosis and graded unihemispheric hypoperfusion leading to cerebral infarction. This model allows for the simultaneous real-time assessment of recanalisation, cerebral perfusion and end-organ damage. Extensive characterisation of the iCAT model validated its suitability for the assessment of thrombolytic and adjunctive antithrombotic therapy. Combining rtPA with the anticoagulant therapy (Argatroban) enhanced recanalisation (41.9% vs 22.2% rtPA alone) and significantly improved cerebral perfusion (laser speckle contrast imaging), leading to a moderate reduction in infarct volumes (TTC) at 24 hours. Collectively, these studies present a novel mouse model for the real-time assessment of recanalisation, reperfusion and end-organ damage.

Styles APA, Harvard, Vancouver, ISO, etc.

29

Gonzalez, Martinez Ignacio Guillermo. « Novel thermal and electron-beam approaches for the fabrication of boron-rich nanowires ». Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-218019.

Texte intégral

Résumé :

Pursuing the development and implementation of novel synthesis techniques to produce nanostructures with an interesting set of properties is a goal that advances the frontiers of nanotechnology. Also of fundamental importance is to revisit well-established synthesis techniques employing a new set of materials as precursors, substrates and catalysts. Fundamental breakthroughs in the field of nanotechnology can be achieved by developing new synthesis procedures as well as by adapting known procedures to new materials. This thesis focuses on both kinds of experiments. A variant of chemical vapor deposition (CVD) has been used to produce Al5BO9 nanowires out of sapphire wafers without the need of a catalyst material. The novelty of the work relies on the formation mechanism of the Al5BO9 nanowires. Essentially, the process can be described as a large-scale topological transformation taking place on the substrate’s surface as its chemical composition changes due to the arrival of precursor molecules. Dense mats of Al5BO9 nanowires cover large areas of the substrate that were previously relatively flat. The process is enhanced by a high temperature and the presence of pre-existing superficial defects (cracks, terraces, etc.) on the substrates. Al5BO9 nanowires as well as B/BOX nanowires and BOX nanotubes were also produced via a novel in-situ electron beam-induced synthesis technique. The process was carried out at room temperature and inside a transmission electron microscope. Au nanoparticles were used as catalyst for the case of B/BOX nanowires and BOX nanotubes, while the Al5BO9 nanowires were synthesized without the need of a catalyst material. The formation and growth of the nanostructures is solely driven by the electron beam. The growth mechanism of the B/BOX nanowires and BOX nanotubes relies on interplay between electrostatic charging of the precursor material (to produce and transport feedstock material) and electron stimulated desorption of oxygen which is able to activate the catalytic properties of the Au nanoparticles. For the case Al5BO9 nanowires a nucleation process based on massive atomic rearrangement in the precursor is instigated by the e-beam, afterwards, the length of some of the nanowires can be extended by a mechanism analogous to that of the growth of the B/BOX nanowires.

Styles APA, Harvard, Vancouver, ISO, etc.

30

Bertrand, Gaël. « Facteurs de survie des jeunes entreprises en France : une approche intersectorielle ». Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON10045/document.

Texte intégral

Résumé :

L’objet de ce travail de recherche est à l’origine de vérifier l’idée largement répandue que peu de jeunes entreprises survivent après leur période de démarrage. Les ambitions de ce travail se concentreront ensuite à tenter de vérifier cette phrase sur la base de la récolte d’une base de données qui conduira cette recherche vers des questions plus sous-jacentes concernant l’explication des causes de la survie à trois ans des jeunes entreprises, dans différents secteurs d’activités. L’analyse de la littérature révèlera un riche corpus relatif au sujet de la survie et plus généralement du succès des jeunes entreprises. Ainsi que nous le montrerons au cours de la revue de littérature, un grand nombre de travaux ont été développés sur ces thématiques, et un grand nombre d’angles de vu seront exposés, sans toutefois atteindre un consensus aussi bien dans la recherche en entrepreneuriat que dans d’autres domaines de recherches tels que le management stratégique ou encore la théorie des organisations. Les développements montreront ainsi, la grande diversité des travaux qui ont été entrepris dans le monde et mettra en lumière le manque de travaux quantitatifs sur cette thématique, notamment en France. La visée de ce travail a ainsi évolué en vue de tenter d’obtenir une vision relativement claire de la notion de survie à trois ans dans le cadre de jeunes entreprises dans des secteurs différents, sur le territoire français. Notre tentative de clarifier les facteurs clés de survie reste mitigée du fait notamment de la très grande diversité des résultats obtenus pour chaque secteur. La dimension intersectorielle a ainsi permis selon nous de montrer, que malgré la grande hétérogénéité des résultats antérieurs relevés, voire les contradictions mises en lumières, il est envisageable que ces résultats soient singuliers aux secteurs et époques auxquels ils ont été mesurés. Il nous semble ainsi naturel de penser que les facteurs clés de survie des jeunes entreprises soient fluctuants selon les années, renforçant ainsi la complexité de l’analyse de cette thématique dans la recherche en entrepreneuriat. Il semble donc, que seuls des travaux entrepris à un niveau aussi bien global (comme le Global Entrepreneurship Monitor) ou plus précis avec des démarches plus qualitatives, soient tout à fait nécessaires pour comprendre de manière approfondie le phénomène de survie des jeunes entreprises
The purpose of this research is to verify the origin of the general belief that few young businesses survive beyond their start-up period. We attempt to verify this idea on the basis of a database which had lead this research to more precise questions about the primary explanation of the three-year survival of young firms in different sectors. The analysis of the literature reveals a rich body on survival and more generally on successful young businesses. As we show in the literature review, many works have been developed on these themes, and a large number of points of view have been found andexposed, without reaching any agreement as well as in Entrepreneurship research as in other research areas such as strategic management or organizational theory. Developments and debates show the great diversity of work that was undertaken in the world on this theme and have highlighted the lack of quantitative work on this theme especially in France. The aim of this work has evolved in an attempt to obtain a relatively clear sight-seeing of the notion of survival for three years in different sectors, on the French territory. Our attempt to clarify the key factors for survival remains mixed mainly because of the great diversity of results obtained for each sector. The intersectoral focus shows that despite the heterogeneity of previous results, as highlighted contradictions, it seems believable that these results are exclusive to sectors and times at which they were measured. It also seems natural to think that the key factors for survival of newly founded firms are fluctuating throughout the years, and reinforcing the complexity of the analysis of this topic in entrepreneurship research.It appears that only works undertaken at a global level (Like the GEM) as well as more precise researches with qualitative approaches are quite necessary to understand thoroughly the phenomenon of survival of young firms. However, it seems in addition that this diversity could contribute to a more global explanation of these issues, given example the GEM in Europe, which appears necessary to get a more accurate and complete vision of survival of newly founded firms

Styles APA, Harvard, Vancouver, ISO, etc.

31

Diakhate, Djibril. « Veille technologique et intelligence économique en PME et TPE : réalités d'une approche nouvelle avec le Web 2.0 ». Thesis, Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX32089.

Texte intégral

Résumé :

Avec les mutations de l’internet induites par le développement des outils collaboratifs (blogs, flux RSS, réseaux sociaux, partage d’informations...) l'information change de nature. Sa production devient de plus en plus simple. L'utilisateur, qui depuis les débuts de l’internet grand-public, se contentait d’un rôle de consommateur tout-court d'informations s'est, petit-à-petit, transformé en « consommateur-producteur ». Il est au cœur du nouveau système de production et de diffusion de l’information. Ce changement qui s'opère dans toutes les couches sociales avec comme caractéristiques principales la floraison des blogs, la veille personnalisée, la customisation des outils, le partage, la collaboration dans les réseaux sociaux ..., s’identifie à travers les appellations « web 2.0 », « web social », « web collaboratif ». Plus que des mots, il s’agit de pratiques informationnelles qui mettraient en cause les acquis des entreprises en matière de veille et d'Intelligence Économique. Ainsi, l'intérêt de mesurer les tenants et les aboutissants de ce renouvellement des usages informationnels nous pousse à travers cette thèse à s’interroger sur leur impact réel ou supposé dans la veille et l'Intelligence Économique. Ce travail propose de mesurer le degré de récupération des compétences des utilisateurs du web 2.0 dans les démarches de veille et d’IE en PME et TPE. À l’issue d’une enquête de terrain portant sur un échantillon de 70 entreprises de différentes régions du monde (France, États-Unis, Grande-Bretagne, Maroc, Sénégal…) il a été intéressant de constater que le web 2.0 est assez bien connu dans les entreprises quelle que soit leur taille. Toutefois, la récupération de ses applications dans une démarche de veille et d’Intelligence Économique reste assez dispersée du fait, notamment, de la méconnaissance des potentialités de certains outils, qui a comme conséquence leur non prise en compte dans les politiques informationnelles. Ce résultat nous a convaincu de proposer aux TPE et aux PME une démarche de mise en place d’un dispositif de veille collaborative qui a l’originalité d’intégrer les outils du web 2.0. S’inscrivant dans la logique d’un dispositif de veille de seconde génération (Lietzelman et al.), la démarche proposée constitue une amélioration de celles déjà existantes (AFNOR, Paul Degoul). Elle prend en compte dans chacune des phases (conception, planification et mise en œuvre) la dimension sociale de l’internet et de ses pratiques. Un exposé de techniques d’exploitation de certains de ces outils pour un problème de veille a été produit afin de sensibiliser sur leurs potentialités dans l’éventualité de leur intégration dans un système de veille et d’intelligence économique
With the web as a platform and the development of collaborative tools (blogs, RSS feeds, social networking, information sharing ...) information is changing and its production becomes increasingly simple. The average user, who since the advent of the Internet has merely a short role as consumer of information, is transformed into a "consumer-producer" of information. He is at the heart of the new system of production and dissemination of information. This change whose characteristics cannot be ignored: blogs, personal monitoring, social bookmarking, personalization tools for research, collaboration in social networks etc. and known under the names "Web 2.0", "social web", "collaborative web" would undermine the achievements of companies in terms of information monitoring and Competitive Intelligence (CI); hence the importance of measuring the ins and outs of this renewal informational practices. In addition to questions about the real or supposed changes in information monitoring and Competitive Intelligence in the Age of social web, our research also wanted to measure the degree of recovery skills of web 2.0’s users in SMEs CI‘s systems. With a field survey covering a sample of 70 companies from different regions of the world (France, USA, Great Britain, Morocco, Senegal ...) we noticed that the Web 2.0 is fairly well known by companies regardless of their size, but the recovery of its applications in a process to monitor information is dispersed (using disparate, breach of certain tools potential, lack of information policy incorporating tools 2.0...). This result has convinced us to propose to the SME an approach of establishing a collaborative information monitoring system which has the originality to include the tools of Web 2.0 since the phases of design, planning and implementation. In order to respect the logic of a second generation Information Monitoring System (Lietzelman et al.), the proposed approach is an improvement of existing ones like the AFNOR system or that of Paul Degoul. It is accompanied, for sensitizing SME by a statement of operational techniques of some social media tools for their possible inclusion in a Competitive Intelligence System

Styles APA, Harvard, Vancouver, ISO, etc.

32

Peter, Joe Suresh, et Omer Mohamed. « Determinants of Technology Acceptance Among Preschools Teachers in Sweden : A mixed methodological approach ». Thesis, Uppsala universitet, Industriell teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454695.

Texte intégral

Résumé :

There is a lot of demand from society or the government to incorporate ICT into preschool and education in general. However, no research in this area has been found that specifically cites technology's capacity to address concerns connected to planning, and systematic quality work in the preschool context. Technology integration, on the other hand, has ramifications for teachers, who face first- and second-order barriers to technological acceptance. In this study, we identify the determinants of technology acceptance among preschool teachers in Sweden. This study follows a mixed-method approach that comprises 12 semi-structured interviews and a self-completion survey of 9 respondents. The qualitative results were analyzed by a thematic analysis process and the quantitative results with descriptive statistics. We identified that job relevance, external control, result demonstrability, output quality and internal control are the main determinants that play a crucial role in technological acceptance. We also found the persistence of the first-order barrier to the acceptance of technology. This finding contradicts an earlier study where it was stated that the first-order barriers were decreasing in schools. It was, however, discovered that several first-order obstacles in the form of external control factors still exist. Furthermore, it was also found that social factors such as voluntariness, image and subjective norm did not play a crucial role in technology acceptance. Finally, our results show that the use of technology has helped teachers in the documentation and planning, as well as identify the benefits of systematic quality work.

Styles APA, Harvard, Vancouver, ISO, etc.

33

Breitenbach, Tim [Verfasser], Thomas [Gutachter] Dandekar et Roy [Gutachter] Gross. « A mathematical optimal control based approach to pharmacological modulation with regulatory networks and external stimuli / Tim Breitenbach ; Gutachter : Thomas Dandekar, Roy Gross ». Würzburg : Universität Würzburg, 2019. http://d-nb.info/1189589230/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

34

Reiner, Tim-Christopher [Verfasser], et C. [Akademischer Betreuer] Dachsbacher. « Interactive Procedural Modeling Approaches and Visual Illumination Inspection Techniques for Virtual Scenes / Tim-Christopher Reiner ; Betreuer : C. Dachsbacher ». Karlsruhe : KIT-Bibliothek, 2018. http://d-nb.info/1151229296/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

35

Friedrichs, Stefanie Verfasser], Heike [Akademischer Betreuer] Bickeböller, Thomas [Gutachter] [Kneib et Tim [Gutachter] Beißbarth. « Kernel-Based Pathway Approaches for Testing and Selection / Stefanie Friedrichs ; Gutachter : Thomas Kneib, Tim Beißbarth ; Betreuer : Heike Bickeböller ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/114137952X/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

36

Tekouo, Moutchiho William Brice [Verfasser], Gunther [Akademischer Betreuer] Reinhart et Tim Christian [Akademischer Betreuer] Lüth. « A New Programming Approach for Robot-based Flexible Inspection Systems / William Brice Tekouo Moutchiho. Gutachter : Tim Christian Lüth ; Gunther Reinhart. Betreuer : Gunther Reinhart ». München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1024161579/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

37

Nalbantis, Georgios [Verfasser], et Tim [Akademischer Betreuer] Pawlowski. « Perceived game uncertainty and suspense : A test of the uncertainty of outcome hypothesis using a stated preference approach / Georgios Nalbantis ; Betreuer : Tim Pawlowski ». Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1167247884/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

38

Tekouo, Moutchiho William Brice [Verfasser], Gunther Akademischer Betreuer] Reinhart et Tim C. [Akademischer Betreuer] [Lüth. « A New Programming Approach for Robot-based Flexible Inspection Systems / William Brice Tekouo Moutchiho. Gutachter : Tim Christian Lüth ; Gunther Reinhart. Betreuer : Gunther Reinhart ». München : Universitätsbibliothek der TU München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20120425-1096307-1-7.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

39

Kumar, Rethinagiri Santhosh. « Une approche système pour l'estimation de la consommation de puissance des plateformes MPSoC ». Phd thesis, Université de Valenciennes et du Hainaut-Cambresis, 2013. http://tel.archives-ouvertes.fr/tel-00921894.

Texte intégral

Résumé :

Avec l'essor des nouvelles technologies d'intégration sur silicium submicroniques, la consommation de puissance dans les systèmes sur puce multiprocesseur (MPSoC) est devenue un facteur primordial au niveau du flot de conception. La prise en considération de ce facteur clé dés les premières phases de conception, joue un rôle primordial puisqu'elle permet d'augmenter la fiabilité des composants et de réduire le temps d'arrivée sur le marché du produit final. Dans cette thèse, nous proposons une méthodologie efficace pour l'estimation de la consommation de puissance des plateformes MPSoC. Cette méthodologie repose sur une combinaison d'une analyse fonctionnelle de la puissance (FLPA) pour l'obtention des modèles de consommation et d'une technique de simulation au niveau transactionnel (TLM) pour calculer la puissance de l'ensemble du système. Fondamentalement, FLPA est proposée pour modéliser le comportement des processeurs en terme de consommation afin d'obtenir des modèles paramétrés de haut niveau. Dans ce travail, FLPA est étendue pour mettre en place des modèles de puissance génériques pour les différentes parties du système (mémoire, logique reconfigurable, etc.). En outre, un environnement de simulation a été développé au niveau transactionnel afin d'évaluer avec précision les activités utilisées dans les modèles de consommation. La combinaison de ces deux parties conduit à une estimation de la puissance hybride qui donne un meilleur compromis entre la précision et la vitesse. La méthodologie proposée a plusieurs avantages: elle estime la consommation du système embarqué dans tous ses éléments et conduit à des estimations précises sans matériel coûteux et complexe. La méthodologie proposée est évolutive pour explorer des architectures complexes embarquées. Notre outil d'estimation de puissance au niveau du système PETS (Power Estimation Tool at System-level) est développé sur la base de la méthodologie proposée. L'efficacité de notre outil PETS en termes de précision et rapidité est validée par des architectures embarquées monoprocesseur et multiprocesseur conçues autour des plateformes OMAP (3530 et 5912) et FPGA Pro Xilinx Virtex II.

Styles APA, Harvard, Vancouver, ISO, etc.

40

Gentner, Janene Margaret. « Tissue analysis : multidisciplinary approach using FT-IR microspectroscopy and visual microscopy ». Thesis, Queensland University of Technology, 2001.

Trouver le texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

41

Parlanti, Paola. « Neurodegenerative disorders : overcoming single-method limits through the application of a new correlative imaging approach ». Doctoral thesis, Scuola Normale Superiore, 2018. http://hdl.handle.net/11384/85907.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

42

Giang, Thomas Tam [Verfasser], et Henrike [Akademischer Betreuer] Scholz. « Dissecting the Translation of Olfactory Information Processing into Approach Behavior using Orco and Octopamine Signaling in Drosophila melanogaster / Thomas Tam Giang. Gutachter : Henrike Scholz ». Köln : Universitäts- und Stadtbibliothek Köln, 2015. http://d-nb.info/1079321586/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

43

Leimeister, Chris-Andre [Verfasser], Burkhard [Akademischer Betreuer] Morgenstern, Johannes [Gutachter] Söding et Tim [Gutachter] Beissbarth. « Filtered spaced-word matches : a novel approach to fast and accurate sequence comparison / Chris-Andre Leimeister ; Gutachter : Johannes Söding, Tim Beissbarth ; Betreuer : Burkhard Morgenstern ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1176189530/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

44

El, Ghazi Hamid. « Une approche multi-vues pour la gestion de la traçabilité des exigences : (MV-TMM multi view traceability management method) ». Paris 1, 2009. http://www.theses.fr/2009PA010037.

Texte intégral

Résumé :

Après une étude de l'état de l'art dans le domaine de la traçabilité des exigences, nous avons constaté que la gestion de la traçabilité a fait l'objet de plusieurs travaux de recherche. Malgré ces travaux, nous constatons que les entreprises rencontrent encore des difficultés à intégrer la traçabilité dans leurs processus de développement. Cela est dû au manque de mécanisme de représentation des différents types d'informations de traçabilité ainsi qu’à la méconnaissance du processus de traçabilité des exigences dans un projet. Le travail de cette thèse propose une solution dénommée MV-TMM (une démarche multi-vues pour la gestion de la traçabilité) et (ii) un processus intentionnel décrivant les étapes nécessaires pour la construction et l'usage des informations de traçabilité. Le méta-modèle de la démarche MV-TMM est multi-vues car il représente les différents points de vue d'utilisation des informations de traçabilité dans un projet. En outre, le contenu du méta modèle décrit quatre dimensions liées au domaine de la traçabilité des exigences: la dimension contexte projet, la dimension point de vue, la dimension élément de trace et la dimension de lien de traçabilité. En plus du méta modèle, la démarche MV-TMM propose également un processus composé de deux étapes principales. Une première étape se focalise sur la construction d'un modèle de traçabilité qui s'adapte au contexte d'un projet. La deuxième étape se préoccupe, quant à elle, du guidage de la capture et de l'utilisation des informations de traçabilité.

Styles APA, Harvard, Vancouver, ISO, etc.

45

Macedo, Vedilaine Aparecida Bueno da Silva. « Abordagem farmacocinética/farmacodinâmica (PK/PD) da vancomicina no controle da sepse por patógenos gram-positivos em pacientes queimados críticos pediátricos ». Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-06122017-111756/.

Texte intégral

Résumé :

INTRODUÇÃO - OBJETIVO: A vancomicina é um glicopeptídeo de primeira escolha largamente prescrito aos pacientes críticos no tratamento de infecções graves causadas por patógenos nosocomiais Gram-positivos susceptíveis. Os pacientes grandes queimados são considerados pacientes críticos pelas condições metabólicas e importantes alterações fisiopatológicas decorrentes do choque séptico que modificam a farmacocinética da vancomicina. Destaca-se, entretanto que nos pacientes críticos queimados pediátricos essa alteração ocorre em diferente proporção quando comparada aquela reportada para pacientes adultos. Assim sendo, a efetividade desse antimicrobiano é um desafio para a equipe clínica da terapia intensiva, uma vez que a dose empírica nesses pacientes tem fornecido concentrações inferiores às recomendadas, resultando em falha terapêutica pela falta de cobertura do antimicrobiano contra patógenos susceptíveis, CIM ≥1mg/L. O objetivo foi realizar o monitoramento das concentrações plasmáticas de vancomicina seguido da abordagem farmacocinética-farmacodinâmica (PK/PD) a fim de se avaliar a efetividade do regime empírico recomendado ao paciente crítico pediátrico e se realizar o ajuste de dose para erradicação dos patógenos. CASUÍSTICA E MÉTODOS: Incluíram-se 20 pacientes (14M/6F), função renal normal com média de idade 5,95 (4,5-7,4) anos, peso 25,2 (20,5-30)kg, superfície de área queimada total 31,1(25-37)%. Os acidentes foram causados pelo fogo/ combustão por álcool; registrou-se lesão inalatória (12/20) e uso de drogas vasoativas e ventilação mecânica em 13/20 pacientes. Os exames de rotina laboratorial foram realizados diariamente; antes do início da terapia antimicrobiana, colheram-se amostras de sangue no D0 para cultura e realização do teste de susceptibilidade. Os pacientes foram investigados em diferentes seguimentos durante o choque séptico; o regime de dose empírica recomendada pelo CCIH foi prescrito e 3-4 amostras seriadas de sangue (1,5 mL/cada) foram coletadas do CVC no intervalo de dose após a dose diária empírica recomendada e após a individualização da terapia medicamentosa. A quantificação de vancomicina plasmática foi realizada através da cromatografia líquida. Na modelagem PK utilizou-se o programa PK Solutions Noncompartmental Data Analysis versão 2.0. Na abordagem PK/PD e no tratamento estatístico aplicou-se o programa GraphPad Prisma v.5.0. Empregou-se a razão da área sob a curva (ASCss0-24) e concentração inibitória mínima superior a 400 (ASCss0-24/CIM>400) como índice preditivo de efetividade recomendada para o antimicrobiano. Aplicou-se estatística paramétrica com relação aos dados demográficos e laboratoriais, e estatística não paramétrica com relação à dose, concentração plasmática, área sob a curva, constantes farmacocinéticas e efetividade do antimicrobiano. Aplicaram-se nesse estudo os testes paramétricos (ANOVA e Teste T de Student) e não paramétricos (Wilcoxon e Mann Whitney) no programa GraphPad Prisma v.5.0., e o nível de alfa igual ou inferior a 0,05 (P<0,05) foi considerado na significância estatística. RESULTADOS: A dose empírica de vancomicina foi 50 (44-51) mg/kg dia, mediana (quartis, IQ25-75) mostrou que o alvo foi atingido para 85% (17/20) dos pacientes apenas contra cepas sensíveis (CIM&≤1mg/L), ficando desta forma todos os pacientes desprotegidos contra cepas CIM >1mg/L (CIM: 2-4 mg/L). Então, registrou-se alteração de conduta médica relativa à prescrição com aumento da dose diária de vancomicina 94 (85-104) mg/Kg. Esse aumento se mostrou significativo com relação a dose inicial empírica, p<0,05. Após nova estabilização pela terapia dose ajustada, e coletas de sangue no platô, o alvo PK/PD foi alcançado para todos os pacientes, contra patógenos CIM 1mg/L. Entretanto, apenas 5/20 pacientes alcançaram o alvo PK/PD contra cepas susceptíveis CIM: 2mg/L, sendo que nenhum paciente se mostrou coberto contra cepas CIM 4mg/L. CONCLUSÃO: O regime empírico de dose recomendado para a vancomicina não se mostrou efetivo contra os patógenos sensíveis isolados. Concluindo, o controle terapêutico, estudo da farmacocinética e abordagem PK/PD realizado em tempo real possibilitou a alteração precoce de prescrição da vancomicina nos pacientes pediátricos grandes queimados de forma a otimizar a terapia antimicrobiana e o controle das infecções causadas por patógenos hospitalares susceptíveis (CIM ≥1mg/L).
INTRODUCTION- OBJECTIVE: Vancomycin is a first choice glycopeptide largely prescribed to critically ill adult or pediatric patients under therapy of severe infections caused by gram-positive susceptible nosocomial strains. Burn patients have metabolic conditions that change the pharmacokinetics of vancomycin in the treatment of severe infections. Pediatric patients are even more complicated because pharmacokinetic changes are quite different compared to adults, then effective vancomycin dose regimen is a challenge to clinic staff, once the initial dose recommended cannot reach the target against MIC ≥ 1 mg/L strains. Then therapeutic fail with impact on desired outcome. Therefore the rational of study was to apply therapeutic drug plasma monitoring (TDM) in order to identify the pharmacokinetic changes that occur in paediatric burns through PK/PD approach to perform in a real time the dose adjustment required. METHODS - CASUISTRY: Twenty septic burn pediatric patients was investigated after the admission in the Intensive Care Unit of Burns (ICBU) Plastic Surgery Division of HCFMUSP. Vancomycin empiric dose regimen recommended was prescribed 500mg every 6 hours, and patients received one hour drug infusion. Blood sampling was performed after drug infusion at time dose interval (1.5 mL/tube, sodium EDTA): 2nd or 3rd h, 4th, and before the next dose. Vancomycin was quantified by liquid chromatography (LC). Pharmacokinetics was investigated on the basis on one compartment open model by Noncompartmental Data Analysis PK Solutions v 2.0, software. PK/PD approach was based on the ratio of area under the plasma concentration - time curve (AUCss0-24) and the minimum inhibitory concentration (MIC) performed by GraphPad Prism v 5.0 software. The predictive index of drug effectiveness recommended was ASCss0-24/CIM>400. Statistics also was performed through by GraphPad Prism v 5.0 software by application of parametric tests to demographic data and also to laboratorial data (ANOVA, Student T test). Nonparametric statistics was applied related to dose, drug plasma measurements and AUC, kinetic data, data related to drug effectiveness (Mann Whitney). Statistical significant difference was considered, alpha lower than 0,05 (P<0,05). RESULTS -CONCLUSION: It was shown that the therapeutic target was reached to 85% (17/20) patients with the empiric daily dose of vancomycin (44-51) mg/kg, median (quartiles, IQ25-75) only for susceptible strains (MIC≤1mg/L). Then, changes of the prescription occurred in a real time and the daily dose was increased to 94 (85-104) mg/kg, p<0.05. New blood sampling was done at the steady state for TDM, PK and PK/PD approach and the target was reached for all patients MIC 1 mg/L strains; while the target was reached only 5/20 patients against MIC: 2mg/L susceptible strains, and none patient reached the target against MIC 4mg/L strains. It was shown that the drug effectiveness wasn\'t guaranteed by the vancomycin dose regimen recommended for the treatment of sepsis caused by nosocomial MIC≥1mg/L strains. In conclusion, TDM, pharmacokinetic study and PK/PD approach must be considered important tools do change vancomycin prescription in a real time in order to optimize the antimicrobial treatment of septic shock caused by nosocomial pathogens.

Styles APA, Harvard, Vancouver, ISO, etc.

46

Patriarchi, Viola. « Relazione tra prestazioni di TBM EPB di grande diametro in ammassi complessi e parametri strutturali e meccanici - Criticità e approcci risolutivi ». Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3288/.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

47

Abel, Lydia. « Teacher Development Mediation : A Cognition-based Reconsideration ». University of the Western Cape, 1997. http://hdl.handle.net/11394/8320.

Texte intégral

Résumé :

Philosophiae Doctor - PhD
The research was prompted by two main issues prevalent in South African education in the last decade. These were particularly the critical state of the schooling system, especially in the educationally disadvantaged schools (mainly ex-Department of Education and Training) and the relationship of the teacher to teaching and the related issue of teacher upgrading. The resultant effect was that the educationally disadvantaged communities became more and more disadvantaged over time because of decreasing mental stimulation and mental development. The answer lay in finding a theory of intellectual growth and development which takes into account the learning environment of the disadvantaged child. The Educational Support Services Trust (ESST) has been active in addressing this very issue since 1986. It provides appropriate learner-centred mediational texts to disadvantaged pupils around the country. These materials concentrate on the development of practical intelligence by relating leaming to everyday experience. The Teachers' Methodology Project was designed to change the teachers who were using the ESST materials from being disseminators of information to being managers of a learning-centred classroom environment. The idea was to change the way that teachers thought about teaching and learning. This was accomplished by sharing the methodology of the existing pupils' materials and theories of cognition and mediation with them so that they could become adept at mediating at the level of deconstruction of complex ideas and using this knowledge in the construction and development of their own learning materials, thereby contributing to the mental development of their pupils. My experience as a staff member of the ESST and my background in education provided an entry point to this research via Feuerstein et at's (1980,1991) criteria for mediation, Haywood's (1993) mediational teaching style and a range of other theories and ideas including group work and co-operative learning, graphic organisers, and the ESSTs own theory of mediatory text (Sinclair, 1991). These were consolidated into a learning-centred approach to teaching in which the learner, the teacher and the task become part of the total learning-centred environment. The research began as an investigation of the Teachers' Methdology Project (TMP) and an effort to track teachers' development but grew to include the development of the conceptual mediational framework on which the project was based. This resulted in the development of a classroom observation instrument which was used to evaluate how teachers mediated in their classrooms and how they interacted with pupils. The TMP was implemented through a series of workshops during which teachers examined their assumptions about teaching and learning: explored new avenues for facilitating learning; experienced a learning-centred approach to teaching; acquired new strategies for and knowledge of, theories and atttitudes to teaching and learning and were able to reflect on and practise newly acquired skills in a supportive collegial environment. The research employed a qualitative approach and therefore the documentation of the process took considerable effort. An experiential framework (Kolb, 1974) was used to analyse the process and the results. This mediational experiential framework resulted in a methodology which addressed teachers' attitudes and cognition in a life-related way, taking into account their personal knowledge and experience. The methodology is replicable and has been used in basic adult education and other settings. In addition, the methodology can contribute to the understanding of how Outcomes-based Education could be implemented in South Africa.

Styles APA, Harvard, Vancouver, ISO, etc.

48

Lima, Neto Jose Alves de. « O uso da abordagem CTSA para o ensino de energia tendo o desenvolvimento sustent?vel como eixo tem?tico ». Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/16081.

Texte intégral

Résumé :

Made available in DSpace on 2014-12-17T15:04:58Z (GMT). No. of bitstreams: 1 JoseALN_DISSERT.pdf: 3655718 bytes, checksum: fc5f7e94cad28f2373d73b2d5e0f4481 (MD5) Previous issue date: 2012-05-25
In recent decades, humanity has become increasingly concerned with environmental problems. Proofs of this are increasing initiatives in civil society organizations, private institutions and government actions, either local, state or national actions to promote environmental protection. The goal of this research is to contribute to the formation of citizens more aware of their responsibilities to sustainable development issues, simultaneously to their learning of physics in the secondary school. Thus, we have designed a research project that aims to evaluate the effectiveness of the adoption of the concept of sustainable development as a central theme in physics classes in high school. From this goal, we designed, implemented and evaluate lesson plans that aim not only to construct and apply the concept of energy, but also to understand their transformations and conservation law, as well as their processes of production, distribution and consume in the context of physical laws in which it is involved. Then, it was deliberately provided to students, during classes, to read, interpret and produce texts, by this way being able to think and start to have a critical view of the world around him, as well as absorb the energy concept and understand his occurrence in phenomena of nature and in technologies. The approach used for this was that constraining science, technology, society and environment - STSE. This teaching methodology has been applied in the IFRN Ipangua?u campus, for students of two classes of first year of high school integrated course in agroecology and in technical computing. The survey results show the effectiveness of both methods with respect to the viewpoints of students in relation to the guidelines of sustainable development and the learning of physics content proposed. It is hoped with this dissertation to contribute to the formation of future men and women as citizens environmentally friendly, but also as a source of inspiration for teachers who wish to foster in its students such a critical position about civic education, from their classes
Nas ?ltimas d?cadas a humanidade vem se preocupando cada vez mais com os problemas ambientais. Prova disso s?o as iniciativas cada vez mais frequentes da sociedade civil organizada, das institui??es privadas e tamb?m do governo, seja ele municipal, estadual ou federal, em promover a??es em defesa do meio ambiente. O objetivo desta pesquisa ? contribuir para a forma??o de cidad?os mais criticamente conscientes de suas responsabilidades frente ?s quest?es do desenvolvimento sustent?vel, simultaneamente ? sua aprendizagem de f?sica no ensino m?dio. Dessa maneira, foi elaborado um projeto de pesquisa que tem o objetivo de avaliar a efic?cia da ado??o do conceito de desenvolvimento sustent?vel como eixo tem?tico nas aulas de f?sica no ensino m?dio. Da?, foram elaborados, implementados e avaliados planos de aulas que buscam n?o apenas construir e aplicar o conceito de energia, mas tamb?m compreender suas transforma??es e lei de conserva??o, bem como seus processos de produ??o, distribui??o e consumo no contexto das leis f?sicas em que est? envolvido. Ent?o, foi deliberadamente propiciado ao aluno, durante as aulas, ler, interpretar e produzir textos para, dessa forma, poder pensar e come?ar a ter uma vis?o cr?tica do mundo que o cerca, bem como assimilar o conceito de energia e compreender suas ocorr?ncias nos fen?menos da natureza e das tecnologias. A abordagem utilizada para tal foi a que vincula ci?ncia, tecnologia, sociedade e meio ambiente CTSA. Essa metodologia de ensino foi aplicada no C?mpus Ipangua?u do IFRN, aos alunos de uma turma da primeira s?rie do ensino m?dio de cada um dos seguintes cursos t?cnicos integrados: t?cnico em agroecologia e t?cnico em inform?tica. Os resultados da pesquisa mostram a efic?cia da metodologia tanto no que diz respeito aos posicionamentos dos alunos frente ?s diretrizes do desenvolvimento sustent?vel, quanto ao aprendizado dos conte?dos de f?sica tratados. Espera-se, com esta disserta??o, contribuir para a forma??o de futuros cidad?os e cidad?s, como respeitadores do meio ambiente, e disponibilizar uma fonte de inspira??o para outros professores que desejem despertar nos seus alunos tal postura cr?tica para forma??o de cidadania, a partir de suas aulas

Styles APA, Harvard, Vancouver, ISO, etc.

49

Elkerdawy, Ahmed [Verfasser], et Tim [Akademischer Betreuer] Clark. « CADD Optimization by Using Quantum-Mechanical Approaches for a More Accurate Description of Non-Covalent Intermolecular Interactions / Ahmed Elkerdawy. Gutachter : Tim Clark ». Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2013. http://d-nb.info/1054164487/34.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

50

Hoyt, DaVina J. « Living two lives| The ability of low income African American females in their quest to break the glass ceiling of education through The Ellison Model (TEM) mentoring approach ». Thesis, Washington State University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3587106.

Texte intégral

Résumé :

It is often that during their academic pursuits, to become successful, low-income African-American women must learn to navigate an upstream current through higher education, where the established order in the academy is based on Western European values that often conflict with African-American values (Harper, Patton & Wooden, 2009; Phinney, Ong and Madden, 2000). Because many lack preparation and tools for success in higher education, without immediate intervention, low-income college students tend to experience academic failure during their first semester at the university level (Acevedo and Herrera, 2002).

The present study analyzed eight interview transcripts of African American women, all of whom had been mentored through Hunt's Inclusive Community Building Ellison Model (The Ellison Model) (Hunt, 1994). The data described the participants' experiences in higher education and their perceptions of The Ellison Model and its role in assisting them to overcome the "glass ceiling" in higher education. Analysis of the transcripts involved: (a) emergent coding wherein a preliminary review of the data revealed themes, including (a) mentoring/support, (b) dialogue between mentor and mentee, (c) conflict resolution, (d) The Ellison Model values, and (e) living two lives. Further, categories were created to examine the data more closely.

Findings of the data showed a consensus among the perceptions of these women from low-income background of the existence of a glass ceiling as they pursued higher education. This glass ceiling was perceived variously: (a) an external glass ceiling, (b) a self-imposed glass ceiling, and (c) a lowered glass ceiling. Moreover, the study showed that the women perceived mentoring as an effective means for assisting low-income African American navigate between home and university space, "living two lives" (Hoyt, 2003). Finally, the study showed the profundity of The Ellison Mentoring Model, specifically, as a viable approach to helping low-income African American women overcome the glass ceiling as they pursue higher education. This study has implications for higher education institutions in their efforts to recruit, retain, and graduate more ethnic and gendered minority students, and confirms the benefit of a mentoring component as a major part of student service programs at higher education institutions.

Styles APA, Harvard, Vancouver, ISO, etc.

Thèses sur le sujet « TPM APPROACH »

Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres