Littérature scientifique sur le sujet « Thrombin binding aptamer »
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Articles de revues sur le sujet "Thrombin binding aptamer"
Ponzo, Irene, Friederike M. Möller, Herwin Daub et Nena Matscheko. « A DNA-Based Biosensor Assay for the Kinetic Characterization of Ion-Dependent Aptamer Folding and Protein Binding ». Molecules 24, no 16 (8 août 2019) : 2877. http://dx.doi.org/10.3390/molecules24162877.
Texte intégralKim, Jieun, Dajeong Kim et Jong Bum Lee. « DNA aptamer-based carrier for loading proteins and enhancing the enzymatic activity ». RSC Advances 7, no 3 (2017) : 1643–45. http://dx.doi.org/10.1039/c6ra25507h.
Texte intégralPoturnayová, Alexandra, Maja Šnejdárková et Tibor Hianik. « DNA aptamer configuration affects the sensitivity and binding kinetics of thrombin ». Acta Chimica Slovaca 5, no 1 (1 avril 2012) : 53–58. http://dx.doi.org/10.2478/v10188-012-0009-z.
Texte intégralZhdanov, Gleb, Alexander Arutyunyuan, Alexey Kopylov et Elena Zavyalova. « Energy Dissipation Hypothesis Applied to Enhance the Affinity of Thrombin Binding Aptamer ». Biophysica 1, no 2 (14 mai 2021) : 179–93. http://dx.doi.org/10.3390/biophysica1020014.
Texte intégralBeyer, Stefan, Wendy U. Dittmer, Andreas Reuter et Friedrich C. Simmel. « Controlled Release of Thrombin Using Aptamer-Based Nanodevices ». Advances in Science and Technology 53 (octobre 2006) : 116–21. http://dx.doi.org/10.4028/www.scientific.net/ast.53.116.
Texte intégralKolganova, Natalia A., Vladimir B. Tsvetkov, Andrey A. Stomakhin, Sergei A. Surzhikov, Edward N. Timofeev et Irina V. Varizhuk. « Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer ». International Journal of Molecular Sciences 24, no 9 (7 mai 2023) : 8406. http://dx.doi.org/10.3390/ijms24098406.
Texte intégralFunck, Timon, Tim Liedl et Wooli Bae. « Dual Aptamer-Functionalized 3D Plasmonic Metamolecule for Thrombin Sensing ». Applied Sciences 9, no 15 (26 juillet 2019) : 3006. http://dx.doi.org/10.3390/app9153006.
Texte intégralSeelam Prabhakar, Preethi, Richard A. Manderville et Stacey D. Wetmore. « Impact of the Position of the Chemically Modified 5-Furyl-2′-Deoxyuridine Nucleoside on the Thrombin DNA Aptamer–Protein Complex : Structural Insights into Aptamer Response from MD Simulations ». Molecules 24, no 16 (10 août 2019) : 2908. http://dx.doi.org/10.3390/molecules24162908.
Texte intégralZeng, Xinling, Qing Zhou, Liyan Wang, Xiaoxian Zhu, Kuiyan Cui, Xinsheng Peng, Terry W. J. Steele, Huizhi Chen, Hui Xu et Yubin Zhou. « A Fluorescence Kinetic-Based Aptasensor Employing Stilbene Isomerization for Detection of Thrombin ». Materials 14, no 22 (16 novembre 2021) : 6927. http://dx.doi.org/10.3390/ma14226927.
Texte intégralRusso Krauss, Irene, Andrea Pica, Antonello Merlino, Lelio Mazzarella et Filomena Sica. « Duplex–quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer ». Acta Crystallographica Section D Biological Crystallography 69, no 12 (19 novembre 2013) : 2403–11. http://dx.doi.org/10.1107/s0907444913022269.
Texte intégralThèses sur le sujet "Thrombin binding aptamer"
Trapaidze, Ana. « Integration of thrombin-binding aptamers in point-of-care devices for continuous monitoring of thrombin in plasma ». Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30050/document.
Texte intégralThrombin is the central enzyme in the process of hemostasis. Normally, in vivo concentration of thrombin is rigorously regulated; however, clinically impaired or unregulated thrombin generation predisposes patients either to hemorrhagic or thromboembolic complications. Monitoring thrombin in real-time is therefore needed to enable rapid and accurate determination of drug administration strategy for patients under vital threat. Aptamers, short single-stranded oligonucleotide ligands represent promising candidates as biorecognition elements for new-generation biosensors. The aim of this PhD work therefore is to investigate different solutions for the integration of thrombin-binding aptamers in point-of-care devices for continuous monitoring of thrombin in plasma. The kinetics of aptamer interaction with thrombin and specificity towards prothrombin and thrombin - inhibitor complexes was rigorously investigated using Surface Plasmon Resonance. These experiments unveiled the complex character of interaction of the HD1 with thrombin, confirming nonspecific interactions with prothrombin, natural inhibitors of thrombin, serum albumin whereas another 29-bp aptamer HD22 proved to be highly affine and specific towards thrombin. On the other hand we explored aptamer integration options. We validated the principle and at the same managed to detect different concentrations of thrombin (5-500 nM). We finally proposed a novel approach to increase sensitivity and specificity for thrombin detection based on the engineering of aptadimer structures bearing aptamers HD1and HD22 interconnected with a nucleic acid spacer
Pal, Sohini. « Nanopore Based Single-molecule Sensors ». Thesis, 2020. https://etd.iisc.ac.in/handle/2005/5457.
Texte intégralchen, Ren-hao, et 陳人豪. « Studies of the Binding Mechanism between Aptamers and Thrombin by Surface Plasmon Resonance and Circular Dichroism ». Thesis, 2010. http://ndltd.ncl.edu.tw/handle/09067407226002566458.
Texte intégral國立中央大學
化學工程與材料工程研究所
98
This study characterizes the interaction mechanism between aptamers and human thrombin by surface plasmon resonance (SPR) and ciucular dichroism (CD). Thrombin, a multifunctional serine protease, has both procoagulant and anticoagulant functions in human blood. Thrombin involves two electropositive exosites;one is fibrinogen-binding site and the other is heparin-binding site. Two thrombin-binding aptamers have been selected by SELEX technique over the past decade, respectively. One is 15-mer aptamer binds at fibrinogen-binding site of thrombin, while 29-mer aptamer binds at the heparin binding site of thrombin. In the past years many papers have reported the interaction between 15-mer aptamer and thrombin, however the difference of the two aptamers bind to thrombin is still lacking and worth of investigation. In this study, we combined kinetics and conformational information to compare the binding mechanism between these two aptamers with thrombin. Two experiments were mainly performed in this investigation. CD assay demonstrated the comformational feature of different aptamers binding to thrombin, while SPR provided kinetic constant (Ka) in different binding parameters of aqueous solution (salt concentration and pH). From the results, we found that 20-mer aptamer binding to thrombin by G-guadruplex structure and dominated by electrostatic interactions. The 29-mer aptamer binds to thrombin by hairpin structure and is driven by hydrophobic effects. Furthermore, we comfirmed this argument by Isothermal Titration Calometry measurements . By experimental results, we suggested that the structure of these two aptamers is an important factor to cause the different binding mechanism between these two aptamers with thrombin.
Huang, Chi-Chieh, et 黃繼傑. « Real-Time Detection of α-Thrombin Binding to Single-Strand DNA Aptamers and Dengue Virus DNA Hybridization by ARROW-B SPR Biosensors ». Thesis, 2008. http://ndltd.ncl.edu.tw/handle/73575633967046751075.
Texte intégral國立交通大學
電子工程系所
96
In this thesis, an antiresonant reflecting optical waveguide of type B (ARROW-B) surface plasmon resonance (SPR) biosensor operating in the aqueous environment has been investigated. The ARROW-B SPR biosensor is proposed to provide a label-free, high-throughput and highly surface-sensitive platform to detect the bimolecular interactions in real time. The design and fabrication process of the ARROW-B SPR sensor chips are described and discussed. Besides, the primary analytes for the bioassay experiments are divided into two categories based on different binding characteristics. First, the real-time detection of α-thrombin binding to ssDNA aptamers was under in-depth investigation. The gold nanoparticles modified with anti-thrombin antibodies were employed to bind to the α-thrombins for signal amplification. The detection limit of this biosensor to α-thrombin was measured at 1 pM level, which was comparable to that of the Biacore 3000 system but at much lower cost. Second, the real-time detection of dengue virus ssDNA hybridization was studied. The dengue virus DNA probe was modified with a thiol group at one end to achieve effective immobilization on the Au surface, while the DNA target utilized the complementary sequence to bind to the immobilized probe. In summary, the measurement results have shown that the ARROW-B SPR biosensors can be applied to detect the ssDNA aptamer/α-thrombin interaction and dengue virus ssDNA hybridization both quantitatively and qualitatively in real time.
Chapitres de livres sur le sujet "Thrombin binding aptamer"
Kumar, Jangam Vikram, Wen-Yih Chen, Jeffrey J. P. Tsai et Wen-Pin Hu. « Molecular Simulation Methods for Selecting Thrombin-Binding Aptamers ». Dans Lecture Notes in Electrical Engineering, 743–49. Dordrecht : Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6996-0_78.
Texte intégralLamberti, Ilaria, Jan Rakitka, Tibor Hianik et Lucia Mosiello. « A Piezoelectric Quartz Crystal Sensor Applied for Thrombin-Binding Aptamers ». Dans Lecture Notes in Electrical Engineering, 449–53. Dordrecht : Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1324-6_73.
Texte intégralActes de conférences sur le sujet "Thrombin binding aptamer"
Ma, Xiao, et Pranav Shrotriya. « Study on Specific Binding Interaction Between Protein and DNA Aptamer via Dynamic Force Spectroscopy ». Dans ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93119.
Texte intégralRiccardi, Claudia, Albert Meyer, Jean-Jacques Vasseur, Irene Russo Krauss, Luigi Paduano, François Morvan et Daniela Montesarchio. « Cyclic and pseudocyclic thrombin binding aptamer analogues as improved anticoagulant agents ». Dans 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland : MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11595.
Texte intégralChen, Kok Hao, et Jong Hyun Choi. « DNA Oligonucleotide-Templated Nanocrystals : Synthesis and Novel Label-Free Protein Detection ». Dans ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11958.
Texte intégralHuang, Chi-Chieh, Hsin-Feng Hsu, Sz-Hau Chen, Kun-Yu Tsai, Yang-Tung Huang, Chih-Sheng Lin et Shih-Hsin Hsu. « Real-time detection of α-thrombin binding to single-strand DNA aptamers by a highly sensitive Si-based waveguide SPR biosensor ». Dans Asia Pacific Optical Sensors Conference, sous la direction de John Canning et Gangding Peng. SPIE, 2012. http://dx.doi.org/10.1117/12.915947.
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