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Auteur : Grafiati
Publié le 11 mars 2023

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Articles de revues sur le sujet "The UCPD"

1

Keller, Patrick A., Lorenz Lehr, Jean-Paul Giacobino, Yves Charnay, Françoise Assimacopoulos-Jeannet et Natalia Giovannini. « Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 in Xenopus laevis ». Physiological Genomics 22, no 3 (11 août 2005) : 339–45. http://dx.doi.org/10.1152/physiolgenomics.00012.2005.

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Uncoupling protein 1 (UCP1) is the first UCP described. It belongs to the family of mitochondrial carrier proteins and is expressed mainly in brown adipose tissue. Recently, the family of the UCPs has rapidly been growing due to the successive cloning of UCP2, UCP3, UCP4, and UCP5, also called brain mitochondrial carrier protein 1. Phylogenetic studies suggest that UCP1/UCP2/UCP3 on one hand and UCP4/UCP5 on the other hand belong to separate subfamilies. In this study, we report the cloning from a frog Xenopus laevis (Xl) oocyte cDNA library of a novel UCP that was shown, by sequence homology, to belong to the family of ancestral UCP4. This cloning provides a milestone in the gap between Drosophila melanogaster or Caenorhabditis elegans on one hand and mammalian UCP4 on the other. Xl UCP4 is already expressed in the oocyte, being the first UCP described in germ cell lineage. During development, it segregates in the neural cord, and, in the adult, in situ hybridization shows its expression in the neurons and also in the choroid plexus of the brain. By RT-PCR analysis, it was found that Xl UCP4 is present in all the subdivisions of the brain and also that it differs from mammalian UCP4 by a very high relative level of expression in peripheral tissues such as the liver and kidney. The peripheral tissue distribution of Xl UCP4 reinforces the hypothesis that UCP4 might be the ancestral UCP from which other UCPs diverged from.
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Klingenberg, M., E. Winkler et K. Echtay. « Uncoupling protein, H+ transport and regulation ». Biochemical Society Transactions 29, no 6 (1 novembre 2001) : 806–11. http://dx.doi.org/10.1042/bst0290806.

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The biochemical functions of uncoupling proteins (UCPs) are discussed with the view of UCP1 as a paradigm. In contrast with UCP1, the heterologous expression of UCP3 in yeast is found to result primarily in extra-mitochondrial deposits and thus is unsuitable for studying UCP3 function. On expression in Escherichia coli inclusion bodies, UCPs extracted and incorporated into vesicles showed no H+ transport, only Cl– transport. Only after addition of coenzyme Q was fully nucleotide-sensitive high-H+ transport reconstituted, with UCP1 as well as with UCP2 and UCP3. The newly discovered cofactor role of coenzyme Q in H+ transport is proposed to imply co-operation with fatty acids for the injection of H+ into the UCP channel.
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Carrageta, David F., Laís Freire-Brito, Bárbara Guerra-Carvalho, João C. Ribeiro, Bruno S. Monteiro, Alberto Barros, Pedro F. Oliveira, Mariana P. Monteiro et Marco G. Alves. « Inhibition of Mitochondrial Uncoupling Proteins Arrests Human Spermatozoa Motility without Compromising Viability ». Antioxidants 12, no 2 (8 février 2023) : 409. http://dx.doi.org/10.3390/antiox12020409.

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Mitochondrial uncoupling proteins (UCPs) are central in the regulation of mitochondrial activity and reactive oxygen species (ROS) production. High oxidative stress is a major cause of male infertility; however, UCPs expression and function in human spermatozoa are still unknown. Herein, we aimed to assess the expression and function of the different homologs (UCP1-6) in human spermatozoa. For this purpose, we screened for the mRNA expression of all UCP homologs. Protein expression and immunolocalization of UCP1, UCP2, and UCP3 were also assessed. Highly motile spermatozoa were isolated from human normozoospermic seminal samples (n = 16) and incubated with genipin, an inhibitor of UCPs (0, 0.5, 5, and 50 µM) for 3 h at 37 °C. Viability and total motility were assessed. Mitochondrial membrane potential and ROS production were evaluated. Media were collected and the metabolic profile and antioxidant potential were analyzed by 1H-NMR and FRAP, respectively. The expression of all UCP homologs (UCP1-6) mRNA by human spermatozoa is herein reported for the first time. UCP1-3 are predominant at the head equatorial segment, whereas UCP1 and UCP2 are also expressed at the spermatozoa midpiece, where mitochondria are located. The inhibition of UCPs by 50 µM genipin, resulting in the UCP3 inhibition, did not compromise sperm cell viability but resulted in irreversible total motility loss that persisted despite washing or incubation with theophylline, a cAMP activator. These effects were associated with decreased mitochondrial membrane potential and lactate production. No differences concerning UCP3 expression, however, were observed in spermatozoa from normozoospermic versus asthenozoospermic men (n = 6). The inhibition of UCPs did not increase ROS production, possibly due to the decreased mitochondrial activity and genipin antioxidant properties. In sum, UCPs are major regulators of human spermatozoa motility and metabolism. The discovery and characterization of UCPs’ role in human spermatozoa can shed new light on spermatozoa ROS-related pathways and bioenergetics physiology.
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Borecký, Jirí, Ivan G. Maia et Paulo Arruda. « Mitochondrial Uncoupling Proteins in Mammals and Plants ». Bioscience Reports 21, no 2 (1 avril 2001) : 201–12. http://dx.doi.org/10.1023/a:1013604526175.

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Uncoupling proteins (UCPs) belong to a distinct cluster of the mitochondrial anion carrier family. Up to five different uncoupling protein types were found in mitochondria of mammals and plants, and recently in fishes, fungi and protozoa. They exhibit a significantly conserved structure with several motifs specific to either the whole cluster or protein type. Uncoupling proteins, as well as the whole mitochondrial anion carrier gene family, probably emerged in evolution before the separation of animal, fungi, and plant kingdoms and originate from an anion/nucleotide or anion/anion transporter ancestor. Mammalian UCP1, UCP2, UCP3, and plant uncoupling proteins pUCP1 and pUCP2 are similar and seem to form one subgroup, whereas UCP4 and BMCP1 belong to a different group. Molecular, biochemical, and phylogenic data suggest that UCP2 could be considered as an UCP-prototype. UCP1 plays its biological role mainly in the non-shivering thermogenesis while the role of the other types is unknown. However, hypotheses have suggested that they are involved in the general balance of basic energy expenditure, protection from reactive oxygen species, and, in plants, in fruit ripening and seed ontogeny.
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RICQUIER, Daniel, et Frédéric BOUILLAUD. « The uncoupling protein homologues : UCP1, UCP2, UCP3, StUCP and AtUCP ». Biochemical Journal 345, no 2 (10 janvier 2000) : 161–79. http://dx.doi.org/10.1042/bj3450161.

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Animal and plant uncoupling protein (UCP) homologues form a subfamily of mitochondrial carriers that are evolutionarily related and possibly derived from a proton/anion transporter ancestor. The brown adipose tissue (BAT) UCP1 has a marked and strongly regulated uncoupling activity, essential to the maintenance of body temperature in small mammals. UCP homologues identified in plants are induced in a cold environment and may be involved in resistance to chilling. The biochemical activities and biological functions of the recently identified mammalian UCP2 and UCP3 are not well known. However, recent data support a role for these UCPs in State 4 respiration, respiration uncoupling and proton leaks in mitochondria. Moreover, genetic studies suggest that UCP2 and UCP3 play a part in energy expenditure in humans. The UCPs may also be involved in adaptation of cellular metabolism to an excessive supply of substrates in order to regulate the ATP level, the NAD+/NADH ratio and various metabolic pathways, and to contain superoxide production. A major goal will be the analysis of mice that either lack the UCP2 or UCP3 gene or overexpress these genes. Other aims will be to investigate the possible roles of UCP2 and UCP3 in response to oxidative stress, lipid peroxidation, inflammatory processes, fever and regulation of temperature in certain specific parts of the body.
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Schwartz, Tonia S., Shauna Murray et Frank Seebacher. « Novel reptilian uncoupling proteins : molecular evolution and gene expression during cold acclimation ». Proceedings of the Royal Society B : Biological Sciences 275, no 1637 (29 janvier 2008) : 979–85. http://dx.doi.org/10.1098/rspb.2007.1761.

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Many animals upregulate metabolism in response to cold. Uncoupling proteins (UCPs) increase proton conductance across the mitochondrial membrane and can thereby alleviate damage from reactive oxygen species that may form as a result of metabolic upregulation. Our aim in this study was to determine whether reptiles ( Crocodylus porosus ) possess UCP genes. If so, we aimed to place reptilian UCP genes within a phylogenetic context and to determine whether the expression of UCP genes is increased during cold acclimation. We provide the first evidence that UCP2 and UCP3 genes are present in reptiles. Unlike in other vertebrates, UCP2 and UPC3 are expressed in liver and skeletal muscle of the crocodile, and both are upregulated in liver during cold acclimation but not in muscle. We identified two transcripts of UCP3, one of which produces a truncated protein similar to the UCP3S transcript in humans, and the resulting protein lacks the predicted nucleotide-binding regulatory domain. Our molecular phylogeny suggests that uncoupling protein 1 (UCP1) is ancestral and has been lost in archosaurs. In birds, UCP3 may have assumed a similar function as UCP1 in mammals, which has important ramifications for understanding endothermic heat production.
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Liu, Jing, Ji Li, Wen-Jian Li et Chun-Ming Wang. « The Role of Uncoupling Proteins in Diabetes Mellitus ». Journal of Diabetes Research 2013 (2013) : 1–7. http://dx.doi.org/10.1155/2013/585897.

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Uncoupling proteins (UCPs) are anion carriers expressed in the mitochondrial inner membrane that uncouple oxygen consumption by the respiratory chain from ATP synthesis. The physiological functions of UCPs have long been debated since the new UCPs (UCP2 to 5) were discovered, and the role of UCPs in the pathogeneses of diabetes mellitus is one of the hottest topics. UCPs are thought to be activated by superoxide and then decrease mitochondrial free radicals generation; this may provide a protective effect on diabetes mellitus that is under the oxidative stress conditions. UCP1 is considered to be a candidate gene for diabetes because of its role in thermogenesis and energy expenditure. UCP2 is expressed in several tissues and acts in the negative regulation of insulin secretion byβ-cells and in fatty acid metabolism. UCP3 plays a role in fatty acid metabolism and energy homeostasis and modulates insulin sensitivity. Several gene polymorphisms of UCP1, UCP2, and UCP3 were reported to be associated with diabetes. The progress in the role of UCP1, UCP2, and UCP3 on diabetes mellitus is summarized in this review.
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Jastroch, Martin, Sven Wuertz, Werner Kloas et Martin Klingenspor. « Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis ». Physiological Genomics 22, no 2 (14 juillet 2005) : 150–56. http://dx.doi.org/10.1152/physiolgenomics.00070.2005.

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Uncoupling proteins (UCPs) increase proton leakage across the inner mitochondrial membrane. Thereby, UCP1 in brown adipose tissue dissipates proton motive force as heat. This mechanism of nonshivering thermogenesis is considered as a monophyletic trait of endothermic placental mammals that emerged about 140 million years ago and provided a crucial advantage for life in the cold. The paralogues UCP2 and UCP3 are probably not thermogenic proteins but convey mild uncoupling, which may serve to reduce the rate of mitochondrial reactive oxygen species production. Both are present in endotherms (mammals and birds), but so far only UCP2 has been identified in ectothermic vertebrates (fish and amphibia). The evolution of UCPs is of general interest in the search for the origin of mammalian UCP1-mediated nonshivering thermogenesis. We here show the presence of UCP1 and UCP3 in ectothermic teleost fish species using comparative genomics, phylogenetic inference, and gene expression analysis. In the common carp ( Cyprinus carpio), UCP1 is predominantly expressed in the liver and strongly diminished in response to cold exposure, thus contrasting the cold-induced expression of mammalian UCP1 in brown adipose tissue. UCP3 mRNA is only found in carp skeletal muscle with expression levels increased fivefold in response to fasting. Our findings disprove the monophyletic nature of UCP1 in placental mammals and demonstrate that all three members of the core UCP family were already present before the divergence of ray-finned and lobe-finned vertebrate lineages about 420 million years ago.
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Villarroya, F., S. Brun, M. Giralt, Y. Cámara, G. Solanes et R. Iglesias. « Gene expression of leptin and uncoupling proteins : molecular end-points of fetal development ». Biochemical Society Transactions 29, no 2 (1 mai 2001) : 76–80. http://dx.doi.org/10.1042/bst0290076.

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Uncoupling proteins (UCPs) are considered to be major determinants of energy expenditure in mammals. During development in rodents, the expression of the UCP genes occurs sequentially. UCP2 mRNA is expressed long before birth. UCP1 mRNA expression in brown adipose tissue (BAT) starts in the late fetal period, and the expression of UCP3 mRNA begins immediately after birth in BAT and skeletal muscle. The postnatal induction of UCP1 gene expression is due mainly to cold stimuli, whereas the switch-on of UCP3 mRNA expression after birth requires the stimulus of food intake, specifically of lipids in the mother's milk. However, UCP3 mRNA expression after birth is also highly sensitive to leptin, and administration of a single injection of leptin to neonatal mice that were not allowed to suckle partly mimicked the natural induction of UCP3 gene expression in BAT and skeletal muscle. The speed of the effects of leptin on UCP3 mRNA expression suggests a direct action on skeletal muscle and BAT. The injection of leptin produced minor effects on UCP1 mRNA expression, and no effects were observed on UCP2 mRNA. In summary, leptin appears to contribute to the regulation of UCP3 gene expression in the perinatal period. Whatever the mechanism of action of leptin in BAT and skeletal muscle, it is already functional at birth.
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Mozo, Julien, Gilles Ferry, Aurélie Studeny, Claire Pecqueur, Marianne Rodriguez, Jean A. Boutin et Frédéric Bouillaud. « Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose ». Biochemical Journal 393, no 1 (12 décembre 2005) : 431–39. http://dx.doi.org/10.1042/bj20050494.

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The proton-transport activity of UCP1 (uncoupling protein 1) triggers mitochondrial uncoupling and thermogenesis. The exact role of its close homologues, UCP2 and UCP3, is unclear. Mounting evidence associates them with the control of mitochondrial superoxide production. Using CHO (Chinese-hamster ovary) cells stably expressing UCP3 or UCP1, we found no evidence for respiration uncoupling. The explanation lies in the absence of an appropriate activator of UCP protonophoric function. Accordingly, the addition of retinoic acid uncouples the respiration of the UCP1-expressing clone, but not that of the UCP3-expressing ones. In a glucose-containing medium, the extent of the hyperpolarization of mitochondria by oligomycin was close to 22 mV in the five UCP3-expressing clones, contrasting with the variable values observed with the 15 controls. Our observations suggest that, when glycolysis and mitochondria generate ATP, and in the absence of appropriate activators of proton transport, UCPs do not transport protons (uncoupling), but rather other ions of physiological relevance that control mitochondrial activity. A model is proposed using the known passive transport of pyruvate by UCP1.
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Thèses sur le sujet "The UCPD"

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Liebig, Michaela. « Funktionsanalyse der mitochondrialen Transportproteine UCP2, UCP3, UCPx und SOUP ». [S.l. : s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0138/.

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Kim, Dongho, et n/a. « Regulation of mouse UCP2 and UCP3 gene expression ». University of Otago. Department of Biochemistry, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070424.131549.

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Uncoupling protein, UCP, present in the inner mitochondrial membrane of brown adipose tissue (BAT) contributes to adaptive thermogenesis. UCP functions as a proton pore and can dissipate the proton electrochemical gradient established by the respiratory chain during fuel oxidation, and thus generates heat without producing ATP. However, the brown adipose tissue thermogenesis is not likely to be a major mechanism in controlling energy expenditure for humans because adults have only residual amounts of the tissue. Two new members of the UCP family have been identified based on their high sequence homology to UCP in BAT and named UCP2 and UCP3. The original UCP was renamed UCP1. At the amino acid level, human UCP2 and UCP3 are 59% and 57% identical to UCP1, respectively. In contrast to UCP1, UCP2 is expressed in many tissues such as brown adipose tissue, white adipose tissue, muscle, spleen and macrophages. UCP3 is expressed preferentially in skeletal muscle in humans, and brown adipose tissue and skeletal muscle in rodents. Since their identification many functional studies, including transgenic animals and ectopic expression of UCP2 or UCP3 in yeast, showed uncoupling activity of UCP2 and UCP3. A number of studies have been done that show increased expression of UCP2 and UCP3 by fasting, high-fat diets and suckling of newborn mice. A common characteristic of these circumstances is an associated increase in plasma free fatty acid levels. This study aimed to investigate effects of fatty acids, peroxisome proliferator-activated receptors (PPARs) and other transcription factors on UCP2 and UCP3 gene expression and to explore the molecular mechanism of their regulation through analysis of the promoter of the UCP2 and UCP3 genes. The 3.1 kb and 3.2 kb 5�-flanking regions of the mouse UCP2 and UCP3 genes, respectively, were cloned and used to construct promoter reporter gene (firefly luciferase) plasmids. The cloned region of the UCP2 and UCP3 genes contained putative binding motifs for several transcription factors, including PPAR, myogenin, and MyoD. Luciferase assays of both constructs showed basal promoter activity with 20~190-fold induction for the UCP2 promoter and 1.3~23-fold induction for the UCP3 promoter in several transfected cell lines, including 3T3-L1, C2C12, L6, COS7 and HepG2. Oleic acid (0.3 mM) up-regulated endogenous UCP2 mRNA by 2.3-fold in 3T3-L1 preadipocytes but not in C2C12 myotubes, and UCP3 mRNA by 2.5-fold in C2C12 myotubes. Responsiveness of the cloned promoter to oleic acid reflected the tissue-specific responsiveness of their endogenous genes but with less fold induction, 1.4-fold for UCP2 promoter in 3T3-L1 preadipocytes and 1.5-fold for UCP3 promoter in C2C12 myotubes. Forced expression of PPAR isotypes (PPARα, PPAR[delta] and PPARγ) showed tissue and isotype-specific activation of the UCP2 promoter. UCP2 promoter activity was induced by 2-fold by PPARγ in 3T3-L1 and by 2.8-fold by PPAR[delta] in C2C12. Treatment of oleic acid (0.3 mM) brought about further induction of the UCP2 promoter activity only in 3T3-L1. In contrast, all three isotypes induced activation of the UCP3 promoter in 3T3-L1, C2C12 and HepG2 cells. Treatment with oleic acid (0.3 mM) or isotype-specific agonist (10 [mu]M) resulted in further increased activity of the UCP3 promoter in 3T3-L1 and HepG2 cells. In particular, rosiglitazone (10 [mu]M) induced a 41-fold increase in UCP3 promoter activity in PPARγ transfected HepG2 cells, and this induction returned to basal level by treatment with bisphenol A diglycidyl ether (BADGE) (50 [mu]M), an antagonist for PPARγ. In addition, UCP3 promoter activity increased up to 20-fold 4 days after induction of C2C12 myoblasts differentiation, whereas UCP2 promoter activity increased only up to 2-fold. Forced expression of myogenin and MyoD in C2C12 myoblasts to mimic differentiation, induced UCP3 promoter activity in an additive manner, consistent with UCP3 being regulated by muscle differentiation. In the present study, it has been shown that UCP2 and UCP3 genes are regulated differently by fatty acids. The tissue-type dependence in regulation of endogenous UCP2 and UCP3 paralleled the cell type-specific effect of oleic acid on the promoter-reporter constructs, suggesting that fatty acid effects are at the transcriptional level. UCP2 and UCP3 promoters showed differences in their response to PPARs. Mediation of the fatty acid effect through PPARs has been also demonstrated, but direct binding of PPARs and particular regulatory motifs on the cloned promoter region have not yet been investigated.
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Cassell, Paul Geoffrey. « Genetic susceptibility to type II diabetes and obesity : the role of UCP2, UCP3 and CAPN10 genes ». Thesis, Queen Mary, University of London, 2002. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28813.

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The global prevalence of type 2 diabetes (T2DM) and obesity is increasing, with obesity the most important predisposing factor contributing to the development of T2DM. Epidemiological and genetic evidence supports a major genetic component in both multifactorial and heterogeneous disorders. The identification of disease susceptibility genes in humans could greatly assist in the elucidation of underlying pathophysiological mechanisms and allow the development of more effective preventative and therapeutic strategies for these conditions. Three candidate genes, uncoupling proteins 2 and 3 (UCP2; UCP3) and calpain 10 (CAPN10), are proposed and the rationale for their selection discussed. Gene variants were identified in UCP2 and UCP3. These variants were tested for association with T2DM, obesity and intermediate quantitative traits in a South Indian population and family collection, and also a cohort of British obese case/control subjects. No variant was associated with T2DM. However, investigations revealed positive associations with a UCP2 3'UTR 45bp Ins/Del and a novel UCP3 promoter variant (-55C/T) with variation in body mass (BMI) and fat distribution (WHR) respectively. The results support the view that uncoupling proteins may influence weight gain and hence progression to obesity/T2DM. A significant correlation with plasma leptin levels and the UCP2 Ins/Del variant might indicate one potential mechanism whereby weight could be modulated by uncoupling proteins. A linkage study in affected sibling pairs of North European descent, was negative for the putative T2DM susceptibility gene region, NIDDMI. In contrast, haplotypes of four sequence variants of a T2DM susceptibility gene (CAPN10) identified in this region positively associated with T2DM in a South Indian population. In conclusion, these investigations provide evidence that the three genes studied may contribute to susceptibility for development of T2DM or obesity. However, the findings are in agreement with the most likely genetic model for non-Mendelian complex diseases, that many genes are involved in determining susceptibility to disease with no single gene capable of determining the overall disease phenotype.
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Couplan, Elodie. « Invalidation du gène Ucp2 et surexpression du gène Ucp1 dans le muscle : études de bioénergétique mitochondriale ». Paris 6, 2003. http://www.theses.fr/2003PA066073.

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Van, Der Merwe Pieter de Wet. « UCTD ». Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96877.

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Thesis (MSc)--Stellenbosch University, 2015.
ENGLISH ABSTRACT: Zygophyllum orbiculatum Welwitsch ex Oliv. from Angola and Zygophyllum stapffii Schinz from Namibia were described in the late 1800’s. Recent comparisons of these two species revealed that they were morphologically very similar except that Zygophyllum orbiculatum has unifoliolate leaves and Zygophyllum stapffii has bifoliolate leaves. The similarity of these two species was investigated using nuclear ITS (Internal Transcribed Spacer, i.e. ITS1, 5.8SrDNA, ITS2) region sequence data as phylogenetic markers. Due to almost identical sequences and phylogenetic grouping, it was concluded that they were conspecific. However, the phylogenetic relationships of the major groups within the subfamily Zygophylloideae based on ITS sequences, were unresolved and unsupported, as was found in previous studies using chloroplast gene marker sequences. To resolve the phylogenetic relationships of the major groups within the subfamily Zygophylloideae, a next generation sequencing (NGS) approach was taken. Chloroplasts of taxa representing the major groups within the subfamily were isolated and chloroplast genome sequence data were generated using the Ion Torrent™ sequencer. Additional nuclear ITS cassette data (18SrDNA, ITS1, 5.8SrDNA, ITS2, 26SrDNA) were generated as a by-product and used to produce a large combined aligned sequence matrix for phylogenetic analysis. Model-based phylogenetic programs were able to retrieve strongly supported and resolved phylogenetic relationships of the major groups within Zygophylloideae. Two basal groupings were retrieved in the subfamily. The first grouping consisted of the genera Tetraena, Fagonia and Melocarpum. The second grouping consisted of the monotypic genus Augea and Zygophyllum orbiculatum/stapffii which were embedded within the genus Roepera. Using a gene duplication approach, the chloroplast marker data of genus Zygophyllum sensu stricto placed this genus basal to the Augea, Zygophyllum orbiculatum/stapffii, Roepera clade whilst the nuclear marker data of Zygophyllum sensu stricto, was found in a basal position to the entire subfamily. From this it is concluded that Zygophyllum sensu stricto shows evidence of incomplete lineage sorting. A revised taxonomy for the entire subfamily Zygophylloideae is proposed.
AFRIKAANSE OPSOMMING: Zygophyllum orbiculatum Welwitsch ex Oliv. uit Angola en Zygophyllum stapffii Schinz van Namibië is in die laat 1800's beskryf. Onlangse vergelykings van hierdie twee spesies het getoon dat hulle morfologies baie eners is, behalwe dat Zygophyllum orbiculatum unifoliolate blare besit en dat Zygophyllum stapffii bifoliolate blare besit. Hierdie ooreenkoms is ondersoek, met behulp van die nukleêre “ITS” (Internal Transcribed Spacer d.w.s. ITS1, 5.8SrDNA, ITS2) DNS-strook volgordedata as filogenetiese merkers. As gevolg van feitlik identiese geenopeenvolgings is bevind dat die twee spesies konspesifiek is. Die filogenetiese verwantskappe van die groot binnegroepe van die subfamilie Zygophylloideae, gebaseer op ITS geenopeenvolgings, was egter onopgelos en nie ondersteun nie, net soos in vorige studies waarin chloroplast geenmerkervolgordes gebruik was. Om die filogenetiese verwantskappe van die groot binnegroepe van die subfamilie Zygophylloideae op te los, was ‘n betreklik nuwe DNS volgordebepalingstegniek, naamlik “Next Generation Sequencing” (NGS), gebruik. Chloroplaste van taksa, wat die groot groepe binne-in die subfamilie verteenwoordig, is geïsoleer en chloroplast genoomdata is gegenereer met behulp van die Ion Torrent ™ (NGS) DNS-volgordebepaler. Bykomend was die nukleêre “ITS”-kasset volgordedata (18SrDNS, ITS1, 5.8SrDNS, ITS2, 26SrDNS) ook as 'n by-produk gegenereer en ook gebruik om 'n groot gesamentlike DNS oplyningmatriks vir filogenetiese doeleindes. Model-gebaseerde filogenetiese programme was in staat was om sterk ondersteuning en opgeloste filogenetiese verwantskappe van die groot groepe binne-in Zygophylloideae te ontravel. Die subfamilier toon twee basale groeperinge. Die eerste groepering bestaan uit die genera Tetraena, Fagonia en Melocarpum. Die tweede groepering bestaan uit die monotipiese genus Augea en Zygophyllum orbiculatum/stapffii, wat ingebed is binne-in die genus Roepera. Deur ‘n geendupliseringsbenadering te gebruik op die DNS geenopeenvolgings van die verteenwoordigende takson van Zygophyllum sensu stricto, is bevind dat die chloroplast DNS volgordes hierdie groep basaal aan ‘n Roepera/Augea/Zygophyllum orbiculatum/stapffii klade plaas, terwyl die nukleêre DNS volgordes hierdie groep basaal aan die hele subfamilie Zygophylloideae plaas. Hieruit is die gevolgtrekking gemaak dat Zygophyllum sensu scricto bewyse van onvolledige afstammelingsortering toon. ‘n Gewysigde taksonomie vir die hele subfamilie Zygophylloideae word voorgestel.
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Schnor, Noa Pereira Prada [UNESP]. « Associação de polimorfismos dos genes da UCP2 e UCP3 com características sociodemográficas e nutricionais de mulheres em pré operatório para cirurgia bariátrica ». Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/100963.

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Sabe-se que a obesidade possui etiologia multifatorial com forte influência de componentes genéticos. Os genes das UCPs, devido à influência no dispêndio de energia, no metabolismo lipídico, na utilização de glicose, na sensibilidade à insulina, na regulação de espécies reativas de oxigênio, se apresentam associados tanto com a obesidade quanto com suas comorbidades. Porém, poucos são os estudos que avaliaram a associação desses genes com aspectos sócio demográficos, retrospectiva da obesidade e padrões alimentares. Objetivou-se verificar associação de polimorfismos rs659366 (-866G/A) e rs660339 (A55V) do gene da UCP2 e rs1800849 (-55C/T) da UCP3 com características clínicas e nutricionais e com padrões alimentares em candidatas à cirurgia bariátrica. Foi realizado estudo transversal com 308 mulheres candidatas à cirurgia bariátrica com idade entre 21 e 45 anos. Na coleta dos dados foram incluídos: dados sócio-demográficos, peso atual, histórico de peso, estatura, Índice de Massa Corporal, idade de início da obesidade, três recordatórios alimentares de 24 horas, dosagens bioquímicas, exame de ultrassonografia, comorbidades presentes e genotipagem por PCR-real time dos genes selecionados. Foi notado risco de desenvolvimento da obesidade na adolescência em portadoras do alelo A do polimorfismo -866G/A do gene da UCP2 e chance menor de desenvolvimento da obesidade na fase adulta. Portadoras do alelo C do polimorfismo A55V do gene da UCP2 apresentaram risco maior de início da obesidade na idade adulta e portadoras do alelo T apresentaram maior risco de obesidade grau II enquanto que portadoras do alelo T do polimorfismo -55C/T do gene da UCP3 tiveram risco maior de apresentarem superobesidade após ajuste de renda per capita, maternidade e tratamentos para perda de peso. Não foi notada associação dos polimorfismos analisados...
The multifactorial etiology of obesity is strongly influenced by genetic components. Uncoupling protein genes (UCPs) are associated with obesity and its comorbidities because of their influence on energy expenditure, lipid metabolism, glucose use, insulin sensitivity, and regulation of reactive oxygen species. However, only a few studies have assessed whether these genes are associated with sociodemographic factors, obesity history, and eating patterns. This study investigated whether the rs659366 (-866G/A) and rs660339 (A55V) polymorphisms of the gene UCP2 and rs1800849 (-55C/T) polymorphism of the gene UCP3 are associated with the clinical and nutritional characteristics and eating patterns of bariatric surgery candidates. A cross-sectional study was done with 308 female bariatric surgery candidates aged 21 to 45 years. The following data were collected: sociodemographic data, current weight, weight history, height, body mass index, age at obesity onset, three 24-hour food recalls, biochemical tests, ultrasound examination, comorbidities, and real-time polymerase chain reaction genotyping of the genes of interest. Women with the UCP2 -866A allele were more likely to develop obesity during adolescence and less likely to develop it during adulthood. Women with the UCP2 A55V C allele were at higher risk of developing obesity during adulthood and those with the T allele were at higher risk of obesity grade 2. On the other hand, women with the UCP3 -55T allele were at higher risk of super-obesity after adjustment for per capita income, having children, and having undergone weight loss treatments. The study polymorphisms were not associated with eating patterns. After logistic regression of a subsample of 127 women, women with the UCP2 -866G allele were less susceptible to having high cholesterol and homozygotes for the C allele were more susceptible to having high... (Complete abstract click electronic access below)
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Schnor, Noa Pereira Prada. « Associação de polimorfismos dos genes da UCP2 e UCP3 com características sociodemográficas e nutricionais de mulheres em pré operatório para cirurgia bariátrica / ». Araraquara, 2013. http://hdl.handle.net/11449/100963.

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Orientador: Maria Rita Marques de Oliveira
Coorientação: Rozangela Verlengia
Banca: Thaís Borges César
Banca: Anderson Marliere Navarro
Banca: Celso Vieira de Souza Leite
Banca: Telma Maria Braga Costa
Resumo: Sabe-se que a obesidade possui etiologia multifatorial com forte influência de componentes genéticos. Os genes das UCPs, devido à influência no dispêndio de energia, no metabolismo lipídico, na utilização de glicose, na sensibilidade à insulina, na regulação de espécies reativas de oxigênio, se apresentam associados tanto com a obesidade quanto com suas comorbidades. Porém, poucos são os estudos que avaliaram a associação desses genes com aspectos sócio demográficos, retrospectiva da obesidade e padrões alimentares. Objetivou-se verificar associação de polimorfismos rs659366 (-866G/A) e rs660339 (A55V) do gene da UCP2 e rs1800849 (-55C/T) da UCP3 com características clínicas e nutricionais e com padrões alimentares em candidatas à cirurgia bariátrica. Foi realizado estudo transversal com 308 mulheres candidatas à cirurgia bariátrica com idade entre 21 e 45 anos. Na coleta dos dados foram incluídos: dados sócio-demográficos, peso atual, histórico de peso, estatura, Índice de Massa Corporal, idade de início da obesidade, três recordatórios alimentares de 24 horas, dosagens bioquímicas, exame de ultrassonografia, comorbidades presentes e genotipagem por PCR-real time dos genes selecionados. Foi notado risco de desenvolvimento da obesidade na adolescência em portadoras do alelo A do polimorfismo -866G/A do gene da UCP2 e chance menor de desenvolvimento da obesidade na fase adulta. Portadoras do alelo C do polimorfismo A55V do gene da UCP2 apresentaram risco maior de início da obesidade na idade adulta e portadoras do alelo T apresentaram maior risco de obesidade grau II enquanto que portadoras do alelo T do polimorfismo -55C/T do gene da UCP3 tiveram risco maior de apresentarem superobesidade após ajuste de renda per capita, maternidade e tratamentos para perda de peso. Não foi notada associação dos polimorfismos analisados... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The multifactorial etiology of obesity is strongly influenced by genetic components. Uncoupling protein genes (UCPs) are associated with obesity and its comorbidities because of their influence on energy expenditure, lipid metabolism, glucose use, insulin sensitivity, and regulation of reactive oxygen species. However, only a few studies have assessed whether these genes are associated with sociodemographic factors, obesity history, and eating patterns. This study investigated whether the rs659366 (-866G/A) and rs660339 (A55V) polymorphisms of the gene UCP2 and rs1800849 (-55C/T) polymorphism of the gene UCP3 are associated with the clinical and nutritional characteristics and eating patterns of bariatric surgery candidates. A cross-sectional study was done with 308 female bariatric surgery candidates aged 21 to 45 years. The following data were collected: sociodemographic data, current weight, weight history, height, body mass index, age at obesity onset, three 24-hour food recalls, biochemical tests, ultrasound examination, comorbidities, and real-time polymerase chain reaction genotyping of the genes of interest. Women with the UCP2 -866A allele were more likely to develop obesity during adolescence and less likely to develop it during adulthood. Women with the UCP2 A55V C allele were at higher risk of developing obesity during adulthood and those with the T allele were at higher risk of obesity grade 2. On the other hand, women with the UCP3 -55T allele were at higher risk of super-obesity after adjustment for per capita income, having children, and having undergone weight loss treatments. The study polymorphisms were not associated with eating patterns. After logistic regression of a subsample of 127 women, women with the UCP2 -866G allele were less susceptible to having high cholesterol and homozygotes for the C allele were more susceptible to having high... (Complete abstract click electronic access below)
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Barros, Maria Esmeralda. « Monitorização e Gestão da Dor na UCPA ». Master's thesis, Instituto Politécnico de Setúbal. Escola Superior de Saúde, 2015. http://hdl.handle.net/10400.26/8352.

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Relatório de Trabalho de Projeto apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Enfermagem Médico-Cirúrgica
No âmbito do 2º Mestrado em Enfermagem Médico-Cirúrgica da Escola Superior de Saúde – Instituto Politécnico de Setúbal, o presente relatório pretende transmitir todo o processo desenvolvido para a aquisição das Competências Comuns e Específicas do Enfermeiro Especialista em Enfermagem em Pessoa em Situação Crítica. Inserido em contexto da Unidade Curricular Enfermagem Médico-Cirúrgica II, o Estágio III, compreende a implementação do projeto de intervenção em serviço de acordo com a metodologia de projeto com o título “ Monitorização e Gestão da Dor na unidade de cuidados pós-anestésicos”. A sua finalidade é a implementação de instrumentos de avaliação da Dor e a uniformização de procedimentos, numa unidade de cuidados pós-anestésicos de um Hospital do sul do país, de modo que, a presença de Dor e a sua intensidade sejam sistematicamente valorizadas, diagnosticadas, avaliadas e registadas. A dor pós-cirúrgica na unidade de cuidados pós-anestésicos é uma realidade problemática, a sua monitorização e gestão é fundamental para a melhoria da qualidade dos cuidados prestados. Para a consecução deste projeto foram delineados quatro objetivos específicos, bem como todas as atividades necessárias à sua operacionalização. O primeiro foi adequar a norma de intervenção de enfermagem de avaliação da dor na UCPA, o segundo a elaboração de um padrão de documentação de registo sistemático da dor, o terceiro a formação da equipa relativamente à avaliação, gestão e registo da dor e o quarto a elaboração de um caderno temático sobre a problemática em questão. O desenvolvimento de Competências Especificas do Enfermeiro Especialista em Pessoa em Situação Crítica foi também marcada pela realização do projeto de aprendizagens clínicas, seguindo igualmente a metodologia de projeto.
Abstract:Within the extent of the 2nd Master`s Degree in Medical-Surgical Nursing , of the Polytechnic Institute -School of Health - in Setubal, this present report pretends to convey the whole process developed for the acquisition of Common and Specific Competencies of the Nursing Specialist in the Critical Patient Situation. Set in the context of the II Medical-Surgical Nursing course, the III internship consists in the implementation of the intervention project in service in accordance with project methodology entitled "Monitoring and Management of Pain in the post-anesthesia care unit." Its purpose is to implement pain assessment tools and standardization of procedures, in a post-anesthesia care unit of a hospital in the south of the country, so that the presence of pain and its intensity are systematically valued, diagnosed, assessed and registered. Post-surgical pain in the post-anesthesia care unit is a problematic reality, its monitoring and management is the key to improving the quality of care given. To achieve this project were outlined four specific objectives as well as all necessary to its operation activities. The first was to adjust the standard of nursing intervention for pain assessment in a post-anesthesia care unit, the second developing a standard for documentation of systematic recording of pain, the third training staff regarding the assessment, management and registration of pain and the fourth the development of a thematic dossier on the issue in question. The development of Specific Competencies of the Specialist Nurse in Critical Situation Patient care was also marked by the execution of the clinical learning project, equally following the project methodology.
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Sancerni, Tiphaine. « Rôle du transporteur mitochondrial UCP2 dans la leucémie ». Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCC088.

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La protéine mitochondriale UCP2 est un transporteur membranaire, pouvant exporter les intermédiaires du cycle de Krebs 4 carbones. Quand cette protéine est surexprimée dans des cellules de mélanome, elle réoriente le métabolisme cellulaire depuis la glycolyse vers la phosphorylation oxydative diminuant ainsi leur tumorigénicité. UCP2 est également présente dans les cellules immunitaires, contrôlant la prolifération des lymphocytes T activés et limitant la production des espèces réactives de l'oxygène des macrophages. Au cours de ma thèse, nous avons cherché à comprendre quel était le rôle de la protéine UCP2 dans un modèle de cancer immunitaires: les leucémies aiguës lymphoblastiques de type T (LAL-T). Nous avons travaillé in vitro sur 4 lignées de LAL-T et in vivo sur un modèle murin surexprimant Notch 1ICD. Nous avons pu montrer que la protéine UCP2 permet l'utilisation de la glutamine par les cellules cancéreuses, un nutriment primordial pour la survie et la prolifération des LAL-T. Lorsque l'on diminue la protéine UCP2, les LAL-T réorientent leur métabolisme vers la glycolyse. L'inhibition de la protéine UCP2 pourrait être une stratégie d'affaiblir les cellules LAL-T, celles-ci perdant leurs capacitŽs d'adaptation ˆ des contraintes métaboliques (comme lors de métastases ou de chimiothérapie)
UCP2 protein is a C4 metabolites transporter in the inner mitochondrial membrane. It has been shown to decrease proliferation by rewiring metabolism from glycolysis to oxidative phosphorylation when it is overexpressed in melanoma cells. It also controls both activated LT proliferation and macrophages ROS production. Then during my thesis, we chose to investigate UCP2 role in an immune cancer: T-cell acute lymphoblastic leukemia (T-ALL). We studied in vitro 4 T-ALL cell lines and in vivo, a T-ALL mouse model overexpressing Notch1ICD. We showed that UCP2 is able to control glutamine use in T-ALL cells, a primordial nutrient for these cancer cells. When UCP2 is knockdown cells rewired their metabolism toward glycolysis. UCP2 inhibition could be design as a therapy to weaken T-ALL and avoid relapses, main problem after treatment
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Adjeitey, Cyril. « Control of Uncoupling Protein-1 (UCP1) by Phosphorylation and the Metabolic Impact of Ectopic UCP1 Expression in Skeletal Muscle of Mice ». Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24231.

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UCP1 is a member of the mitochondrial transmembrane anion carrier protein superfamily and is required to mediate adaptive thermogenesis in brown adipose tissue (BAT). Once activated, UCP1 uncouples mitochondrial respiration from ATP synthesis, thereby wasting the protonmotive force formed across the mitochondrial inner membrane as heat. It is hypothesized that proton leaks through UCP1 could be a molecular target to combat certain forms of obesity. Although it is well established that UCP1 is regulated by allosteric mechanisms, alternative methods such as post-translational modification still remain to be explored. The aims of the present study were to confirm the phosphorylation of UCP1 and the physiological relevance of this modification. Using isoelectric focusing, we confirmed that UCP1 displayed acidic shifts consistent with phosphorylation in BAT mitochondria isolated from cold exposed versus warm acclimated mice. A mouse model that ectopically expressed UCP1 in skeletal muscle was used to explore the link between the mitochondrial redox status and UCP1 function. Our results show that the expression of UCP1 in skeletal muscle led to decreases in body and tissues weights. In contrast, glucose uptake into skeletal muscle, food intake and energy expenditure was increased with the expression of UCP1. Finally, proton leaks through UCP1 were determined to be increased in isolated mitochondria from transgenic versus wild-type mice. Taken together these results indicate a complex interplay between mitochondrial redox status, post-translational modification and UCP1 function. Elucidation of novel mechanisms regulating UCP1 offers alternatives strategies that can be explored in order to modulate BAT thermogenesis.
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Livres sur le sujet "The UCPD"

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UNESCO, Office Kabul. UNESCO country programming document (UCPD). Kabul : UNESCO Kabul, 2011.

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Robin, Hunter. The UCSD p-system. London : Pitman, 1985.

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Hentea, Călin. Arme care nu ucid. București : Nemira, 2004.

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Barry, Demchak, dir. Advanced UCSD Pascal programming techniques. Englewood Cliffs, N.J : Prentice-Hall, 1985.

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MacCallum, Iain. UCSD Pascal for the IBM PC. London : Prentice-Hall, 1985.

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Poyner, Arthur. UCSD P-system on the Sirius. Portsmouth : Portsmouth Polytechnic, School of Information Science, 1986.

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Lightfoot, David. Pascal (ISO/UCSD) : Een praktische introduktie. Antwerpen : Maarten Kluwer, 1986.

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MacCallum, Iain. UCSD Pascal for the IBM PC. Englewood Cliffs, NJ : Prentice-Hall International, 1986.

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Stan, Stringfellow, dir. Personal computing with the UCSD p-system. 2e éd. Englewood Cliffs : Prentice-Hall, 1986.

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Sindberg, Kim. UCP 600 transport documents. Montgomery Village, MD : The Institute of International Banking Law & Practice, Inc., 2012.

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Chapitres de livres sur le sujet "The UCPD"

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Neilsen, Michael K., Wei-Yang Lu, William M. Scherzinger, Terry D. Hinnerichs et Chi S. Lo. « Unified Creep Plasticity Damage (UCPD) Model for Rigid Polyurethane Foams ». Dans Conference Proceedings of the Society for Experimental Mechanics Series, 89–97. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-21762-8_11.

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Laustsen, Rasmus Dalgaard. « The UCPD and Trademark Average Consumers : Two of a Kind ? » Dans The Average Consumer in Confusion-based Disputes in European Trademark Law and Similar Fictions, 201–21. Cham : Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26350-8_7.

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Galli, Federico. « Online Behavioural Advertising and Unfair Manipulation Between the GDPR and the UCPD ». Dans Data Science, Machine Intelligence, and Law, 109–35. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50559-2_6.

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Rappold, Gudrun, John-John B. Schnog, Victor E. A. Gerdes, Yvonne G. Weber, Jose M. Serratosa, Anna-Elina Lehesjoki, Alessandra Baumer et al. « UCMD ». Dans Encyclopedia of Molecular Mechanisms of Disease, 2135. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_7483.

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Gaudry, Michael J., Kevin L. Campbell et Martin Jastroch. « Evolution of UCP1 ». Dans Brown Adipose Tissue, 127–41. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/164_2018_116.

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Fadini, Alois. « Quelldateifortführung bei UCSD-Pascal ». Dans PC Praxis, 210. Wiesbaden : Vieweg+Teubner Verlag, 1986. http://dx.doi.org/10.1007/978-3-322-86046-0_33.

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Eriksson, Elina, et Anna Swartling. « UCD Guerrilla Tactics ». Dans IFIP Advances in Information and Communication Technology, 112–23. Berlin, Heidelberg : Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-41145-8_10.

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Miranda, Les, et Morten Meldal. « UniChemo Protection (UCP) ». Dans Peptides : The Wave of the Future, 58–60. Dordrecht : Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_23.

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Vašáková, Martina. « Undifferentiated Connective Tissue Disease (UCTD) ». Dans Sine Syndromes in Rheumatology, 37–43. Vienna : Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1541-1_6.

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Fish, Jessica. « UCSD Performance-Based Skills Assessment ». Dans Encyclopedia of Clinical Neuropsychology, 3536–37. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1835.

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Actes de conférences sur le sujet "The UCPD"

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Sankowski, Olga, et Dieter Krause. « Using Multi-Channel Human-System Interaction for User-Centered Product Design ». Dans ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-88091.

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User-centered product design (UCPD) and especially its methods and tools offer a lot of benefits to product development. By using specific data of the user group or by including them into the design process, systems with better functionality and usability arise. However, including the users in an optimum manner means to include them over the whole product development process, which is costly and often too time-consuming regarding the ever shorter product life cycles. An extensive application of UCPD methods is therefore usually not practical for industry. In order to (1) support the user-centered development process in general and (2) support the selection of appropriate UCPD methods, a multi-channel human-system interaction framework is proposed. It is derived from existing human-computer and human-machine interaction models and further includes additional factors influencing the human-system interaction. However, the framework itself needs further and more detailed elaboration and discussion and currently lacks an allocation of UCPD methods.
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Neilsen, Michael, et Paul Vianco. « Unified Creep Plasticity Damage (UCPD) Model for Solder ». Dans ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65387.

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A unified creep plasticity damage (UCPD) model for Sn-Pb and Pb-free solders was developed and implemented into finite element analysis codes. The new model will be described along with the relationship between the model’s damage evolution equation and an empirical Coffin-Manson relationship for solder fatigue. Next, two significant developments were needed to model crack initiation and growth in solder joints. First, an ability to accelerate the simulations such that the effects of hundreds or thousands of thermal cycles could be modeled in a reasonable amount of time was needed. This was accomplished by applying a user prescribed acceleration factor to the damage evolution; then, damage generated by an acceleration factor of cycles could be captured by the numerical simulation of a single thermal cycle. Second, an ability to capture the geometric effects of crack initiation and growth was needed. This was accomplished by replacing material in finite elements that had met the cracking failure criterion with very flexible elastic material. This diffuse crack modeling approach with local finite elements is known to generate mesh dependent solutions. However, introduction of an element size dependent term into the damage evolution equation was found to be effective in controlling mesh dependency. Finally, experimentally observed cracks in a typical solder joint subjected to thermal mechanical fatigue are compared with model predictions.
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Neilsen, Michael, et Paul Vianco. « Unified Creep Plasticity Damage (UCPD) Model for SAC396 Solder ». Dans ASME 2013 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/ipack2013-73074.

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A unified creep plasticity damage (UCPD) model for Sn-Pb and Pb-free solders was developed and implemented into finite element analysis codes. The new model will be described along with the relationship between the model’s damage evolution equation and an empirical Coffin-Manson relationship for solder fatigue. Next, developments needed to model crack initiation and growth in solder joints will be described. Finally, experimentally observed cracks in typical solder joints subjected to thermal mechanical fatigue are compared with model predictions. Finite element based modeling is particularly suited for predicting solder joint fatigue of advanced electronics packaging, e.g. package-on-package (PoP), because it allows for evaluation of a variety of package materials and geometries.
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Бурцева, Татьяна Егоровна, Сардана Аркадьевна Федорова, Николай Алексеевич Барашков et Алена Афанасьевна Никанорова. « POLYMORPHISM OF SNP-MARKERS OF NONSHIVERING THERMOGENESIS GENES UCP1 (RS1800592), UCP2 (RS659366) AND UCP3 (RS2075577) IN THE YAKUTS AND CHUKCHI'S ». Dans Всероссийская научно-практической конференция с международным участием, посвященной 100-летию со дня рождения выдающегося ученого-североведа И.С. Гурвича (1919-1992). Электронное издательство Национальной библиотеки РС (Я), 2019. http://dx.doi.org/10.25693/gurvich.2019burstevate.

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Kankainen, Anu. « UCPCD ». Dans the 2003 conference. New York, New York, USA : ACM Press, 2003. http://dx.doi.org/10.1145/997078.997087.

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Cockton, Gilbert. « UCD ». Dans the 2012 ACM annual conference extended abstracts. New York, New York, USA : ACM Press, 2012. http://dx.doi.org/10.1145/2212776.2212778.

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Azad, Saeed, et Daniel R. Herber. « Investigations Into Uncertain Control Co-Design Implementations for Stochastic in Expectation and Worst-Case Robust ». Dans ASME 2022 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/imece2022-95229.

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Abstract As uncertainty considerations become increasingly important aspects of concurrent plant and control optimization, it is imperative to identify and compare the impact of uncertain control co-design (UCCD) formulations on their associated solutions. While previous work has developed the theory for various UCCD formulations, their implementation, along with an in-depth discussion of the structure of UCCD problems, implicit assumptions, method-dependent considerations, and practical insights, is currently missing from the literature. Therefore, in this study, we address some of these limitations by proposing two optimal control structures for UCCD problems that we refer to as the open-loop single-control (OLSC) and open-loop multiple-control (OLMC). Next, we implement the stochastic in expectation UCCD (SE-UCCD) and worst-case robust UCCD (WCR-UCCD) for a simplified strain-actuated solar array (SASA) case study. For the implementation of SE-UCCD, we use generalized Polynomial Chaos expansion and benchmark the results against Monte Carlo Simulation. Next, we solve a simple SASA WCR-UCCD through OLSC and OLMC structures. Insights from such implementations indicate that constructing, implementing, and solving a UCCD problem requires an in-depth understanding of the problem at hand, formulations, and solution strategies to best address the underlying co-design under uncertainty questions.
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Costello, Fintan J. « UCD-FC ». Dans the 4th International Workshop. Morristown, NJ, USA : Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1621474.1621555.

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Nulty, Paul. « UCD-PN ». Dans the 4th International Workshop. Morristown, NJ, USA : Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1621474.1621556.

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Butnariu, Cristina, et Tony Veale. « UCD-S1 ». Dans the 4th International Workshop. Morristown, NJ, USA : Association for Computational Linguistics, 2007. http://dx.doi.org/10.3115/1621474.1621557.

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Rapports d'organisations sur le sujet "The UCPD"

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Glen, Andrew, et Cathryn Siegrist. Helpful Engineering's Universal Citizen Protection Device (UCPD). Office of Scientific and Technical Information (OSTI), novembre 2020. http://dx.doi.org/10.2172/1727260.

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Neilsen, Michael K., Wei-Yang Lu, William M. Scherzinger, Terry D. Hinnerichs et Chi S. Lo. Unified Creep Plasticity Damage (UCPD) Model for Rigid Polyurethane Foams. Office of Scientific and Technical Information (OSTI), juin 2015. http://dx.doi.org/10.2172/1183947.

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Moeller, N., et J. H. Weare. UCSD Geothermal Chemical Modeling Project : DOE Advanced Brine Chemistry Program. [University of California at San Diego (UCSD)]. Office of Scientific and Technical Information (OSTI), avril 1992. http://dx.doi.org/10.2172/5536634.

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Kim, Jung-Hoon, et Bernard V. Jackson. IPS Space Weather Research : Korea-Japan-UCSD. Fort Belvoir, VA : Defense Technical Information Center, avril 2015. http://dx.doi.org/10.21236/ada615815.

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Ouellette, Brittany, et Nicholas Stull. 2022 Presentation for UCSD Structural Engineering Department. Office of Scientific and Technical Information (OSTI), novembre 2022. http://dx.doi.org/10.2172/1897404.

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Holland, C., G. Tynan et P. Diamond. UCSD Support for Fusion Simulation Project Planning Activity. Office of Scientific and Technical Information (OSTI), novembre 2011. http://dx.doi.org/10.2172/1043049.

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Cowen, Michael, Alan Lemon et Deborah Gill-Hesselgrave. User-Centered Design (UCD) Process Description. Fort Belvoir, VA : Defense Technical Information Center, décembre 2014. http://dx.doi.org/10.21236/ada615926.

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Weare, J. H. UCSD geothermal chemistry program ; Annual progress report, FY 1989. Office of Scientific and Technical Information (OSTI), octobre 1989. http://dx.doi.org/10.2172/6771496.

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Marnane, Janet K. Alternative UCP Structures for the Information Age. Fort Belvoir, VA : Defense Technical Information Center, mai 1998. http://dx.doi.org/10.21236/ada351775.

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Boedo, J. A. Task 3 : UCSD/DIII-D/TEXTOR FY-97--98 accomplishments. Office of Scientific and Technical Information (OSTI), août 1998. http://dx.doi.org/10.2172/656785.

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