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Auteur : Grafiati

Publié le 10 mars 2023

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1

Bagrodia, Aditya, et James F. Amatruda, dir. Testicular Germ Cell Tumors. New York, NY : Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-0860-9.

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2

Derek, Raghavan, dir. Germ cell tumors. Hamilton, [Ont.] : BC Decker, 2003.

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3

Raghavan, Derek. Germ cell tumors. Hamilton [Ont.] : BC Decker, 2003.

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4

G, Jones W., Ward A. Milford et Anderson C. K, dir. Germ cell tumours II : Proceedings of the 2nd Germ Cell Tumour Conference, Leeds, 15-19 April 1985. Oxford [Oxfordshire] : Pergamon Press, 1986.

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5

Germ, Cell Tumour Conference (3rd 1993 Leeds England). Germ cell tumours III : Proceedings of the 3rd Germ Cell Tumour Conference, held in Leeds, UK, on 8th-10th September 1993. Oxford, OX, England : Pergamon Press, 1994.

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6

Imperial Cancer Research Fund (Great Britain). Germ cell tumours of the testis. Sous la direction de Andrews P. W et Oliver, R. T. D. (Roderick Timothy Desmond). Oxford, U.K : Published for the Imperial Cancer Research Fund by Oxford University Press, 1990.

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7

Amatruda, James F., et Aditya Bagrodia. Testicular Germ Cell Tumors : Methods and Protocols. Springer, 2021.

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8

Bagrodia, Aditya, et James Amatruda. Testicular Germ Cell Tumors : Methods and Protocols. Springer, 2020.

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9

Harnden, Patricia. Germ Cell Tumours V. Sous la direction de Patricia Harnden. Springer-Verlag New York, Inc., 2002.

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10

Jones, W. G., et P. Harnden. Germ Cell Tumours III. Elsevier Science Pub Co, 1994.

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11

Jones, W. G., et P. Harnden. Germ Cell Tumours III. Elsevier Science Pub Co, 1994.

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12

Winter, Christian, et Peter Albers. Testicular cancer. Sous la direction de James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0090.

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Testicular germ cell tumours (GCTs) represent the most common solid malignancy of young men aged 15–40 years. The disease is rising in incidence. Germ cell tumours are best divided into those with pure seminoma and non-seminoma (NSGCT) histology. While cryptorchidism is clearly established as a risk factor, the pathogenesis of testicular cancer remains unknown. Familial studies and molecular analyses suggest an association to genetic alterations. Most testicular cancer patients present a primary tumour in the testis. Diagnostic examinations include testis palpation and ultrasound, and measurement of serum tumour markers (AFP, ß-HCG, and LDH). Surgical exploration is obligatory for suspected tumours and radical orchidectomy should be performed if a tumour is found. Prognosis and subsequent treatment depends upon the clinical stage and the IGCCCG classification (in case of advanced GCT disease).

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13

Jones, W. G., et A. Milford Ward. Germ Cell Tumours II. Pergamon, 1985.

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14

Jones, W. G., et A. Milford Ward. Germ Cell Tumours II. Pergamon, 1985.

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15

McGlynn, Katherine A., Ewa Rajpert-De Meyts et Andreas Stang. Testicular Cancer. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0054.

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Testicular cancer is a rare cancer in the general population, but is the most common neoplasm among young men in many countries. It has one of the highest heritabilities of all cancer types. The vast majority of testicular cancers are germ cell tumors; thus the terms “testicular cancer” and “testicular germ cell tumors” (TGCTs) are often used interchangeably. Globally, the incidence of testicular cancer is highest among men of European ancestry and lowest among men of African and Asian ancestries. Incidence rates have been increasing in many countries since at least the mid-twentieth century. Mortality rates, however, have sharply declined in developed countries. While the reason for the decline in mortality rates is well known, reasons for the increase in incidence remain poorly understood. Accumulating evidence supports the hypothesis that most TGCTs are linked to disturbed development of the testes, beginning in utero, but fostered by postnatal events.

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16

Brantus, Paulo V. Testicular Cancer Research Trends. Nova Science Pub Inc, 2007.

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17

Appleyard, I., W. G. Jones et P. Harnden. Germ Cell Tumours III : Proceedings of the Third Germ Cell Tumour Conference Held in Leeds, UK, on 8th--10th September 1993. Elsevier Science & Technology Books, 2013.

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18

Harnden, Patricia, William G. Jones et Jonathan K. Joffe. Germ Cell Tumours V : The Proceedings of the Fifth Germ Cell Tumour Conference Devonshire Hall, University of Leeds, 13th-15th September 2001. Springer London, Limited, 2012.

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19

Harnden, Patricia, William G. Jones et Jonathan K. Joffe. Germ Cell Tumours V : The Proceedings of the Fifth Germ Cell Tumour Conference Devonshire Hall, University of Leeds, 13th 15th September, 20. Springer London, Limited, 2013.

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20

Harnden, Patricia, William G. Jones et Jonathan K. Joffe. Germ Cell Tumours V : The Proceedings of the Fifth Germ Cell Tumour Conference Devonshire Hall, University of Leeds, 13th-15th September, 2001. Springer, 2014.

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21

Goepel, John. Pathology of testicular tumours. Sous la direction de James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0091.

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Tumours of the testis are uncommon and are usually germ cell tumours. They present most often as a scrotal mass in a young man, and are the most frequent malignant tumour in this age group. The incidence has risen over recent decades and is higher in Western Europe. A history of testicular maldescent is a significant risk factor. About 50% are pure seminoma; the remainder non-seminomas may have a single but more usually a mixed histology. Non-seminomas are all called teratoma in the British system. Metastasis readily occurs to paraaortic lymph nodes or the lungs, and some patients present with advanced metastatic disease. Radical orchidectomy is the usual treatment of the primary tumour, with chemotherapy for metastatic disease. There are other tumours that arise in the testis, which will require a different management strategy. Finally, there are tumours that arise in paratesticular tissue or the spermatic cord.

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22

Matin, Angabin, dir. Germ Cell Tumor. InTech, 2012. http://dx.doi.org/10.5772/1620.

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23

Weir, Hannah Kate. Endocrine factors and risk of testicular germ cell cancer. 1997.

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24

Harry. CBD Oil for Germ Cell Tumor : Explore the Therapeutic Power of CBD Oil in Treating Germ Cell Tumor. Independently Published, 2019.

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25

Johnston, Paul H. Management of Nonseminomatous Germ Cell Tumor of the Testis. INTECH Open Access Publisher, 2012.

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26

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, Gareth Morris-Stiff et Madhumita Bhattacharyya. Gynaecological cancers. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0020_update_001.

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Genitourinary cancers examines the malignancies arising in the kidney, ureter, bladder, prostate, testis, and penis. Renal cancer has high propensity for systemic spread, largely mediated by overexpression of vascular endothelial growth factor (VEGF). Treatments include surgery, immunotherapy, and targeted therapy. Wilms tumour, a childhood malignancy of the kidney, warrants specialist paediatric oncology management to provide expertise in its unique pathology, staging, and treatment, often with surgery and chemotherapy. Cancer of the bladder and ureters, another tobacco related cancer, may present as either superficial or invasive disease. The former is managed by transurethral resection and intravesical therapy. The latter may require radical surgery, preoperative chemotherapy, or radiotherapy. Prostate cancer, the commonest male cancer, is an androgen dependent malignancy. It has attracted controversy with regards to PSA screening, and potential over treatment with radical prostatectomy. Division into low, intermediate, and high risk disease according to tumour grade, stage, and PSA helps in deciding best treatment, antiandrogen therapy for metastatic disease, radiotherapy and adjuvant hormone therapy for locally advanced disease, either surgery or radiotherapy for early intermediate risk disease, and active monitoring for low risk cases. Testicular cancer divides according to pathology into seminoma, nonseminomatous germ cell tumours (NSGCT), and mixed tumours, the latter two frequently producing tumour markers, alpha-fetoprotein (AFP) and/or human chorionic gonadotrophin (HCG). Stage I disease is managed by inguinal orchidectomy and surveillance or adjuvant chemotherapy. More advanced disease is managed by chemotherapy, with high probability of cure in the majority. Penile cancer, often HPV related, can be excised when it presents early, but delay in presentation may lead to regional and systemic spread with poor prognosis.

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27

Management of Adult Testicular Germ Cell Tumours : A National Clinical Guideline. Scottish Intercollegiate Guidelines Network, 1998.

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28

Chapman, Hannah, et Christine Elwell. Ovarian and testicular cancer. Sous la direction de Patrick Davey et David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0328.

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Ovarian cancer is the fifth most common cancer in females in the UK. In contrast, testicular cancer is a rare disease: there were 2138 new cases of testicular cancer diagnosed in 2008 in the UK, and only 70 deaths. Ninety per cent of all ovarian cancers are of epithelial origin, although germ cell and sex cord–stromal cell tumours also occur. In contrast, 95% of testicular cancers are germ cell tumours, with stromal cell tumours and lymphomas making up the remaining 5%. This chapter discusses ovarian cancer and testicular cancer, including definitions of the diseases and their etiologies, typical symptoms, uncommon symptoms, demographics, natural history, complications, diagnostic approach, other diagnoses that should be considered, prognosis, and treatment.

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29

Courtney, Albert T. CBD Oil for Germ Cell Tumor : Everything You Need to Know about CBD Oil. Independently Published, 2019.

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30

Carton, James. Urological pathology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198759584.003.0011.

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This chapter discusses urological pathology and covers diseases of the urinary tract managed by urologists. This includes genitourinary malformations, urinary tract infection, urinary tract obstruction, urinary calculi, cystic renal diseases, benign renal tumours, renal cell carcinoma (RCC), childhood renal tumours, urothelial carcinoma, benign prostatic hyperplasia (BPH), prostate carcinoma, testicular germ cell tumours, testicular non-germ cell tumours, paratesticular diseases, urethral diseases, penile diseases, and scrotal diseases.

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31

Felbaum, Daniel R., Jonathan H. Sherman et Walter C. Jean. Pineal Tumors. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190696696.003.0003.

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Pineal region tumors can include a variety of histologies including pineal parenchymal tumor, germ cell tumor, glial tumor, metastasis and meningioma. The workup for pineal region tumors includes standard magnetic resonance imaging for anatomic imaging, as well as cerebrospinal fluid markers to assess for certain germ cell tumors. Cerebrospinal fluid diversion may be necessary if patients present with hydrocephalus. If surgical resection is indicated based on the suspected diagnosis, magnetic resonance venogram is an important study that influences the surgical trajectory. This chapter reviews common pineal region tumors in the setting of a case presentation. Management strategies and surgical approaches are also discussed in this chapter. Pearls for how to select the surgical approach and complication avoidance are also presented.

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32

Thomas, David F. M. Undescended testis and inguinoscrotal conditions in children. Sous la direction de David F. M. Thomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0123.

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The testis descends in response to androgen stimulation in the third trimester of pregnancy. Germ cell maturation which normally occurs in early childhood is impaired or absent in undescended testes. The well-documented phenomenon of secondary ascent is now thought to account for a sizeable proportion of boys undergoing orchidopexy in later childhood. Inguinal hernias and communicating hydroceles are caused by persistence of a patent processus vaginalis. Surgery is always indicated for inguinal hernias but the majority of communicating hydroceles resolve spontaneously. Testicular torsion accounts for 90% acute scrotal symptoms in adolescents, in whom urgent surgical exploration is mandatory unless there is compelling evidence of an alternative diagnosis. Treatment is rarely justified for asymptomatic varicoceles in this age group.

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33

Heidenreich, Axel. Testis cancer. Sous la direction de James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0092.

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Testicular germ cell tumours represent the most common solid neoplasms in the age group of 20 to 40 years. These cancers have an excellent prognosis, with a 90% long-term survival rate due to well-established, interdisciplinary guidelines for diagnosis and treatment. Independent on the clinical stage at time of diagnosis, treatment after orchidectomy is performed on an individual risk adapted approach. In clinical stage I seminoma, active surveillance is the recommended therapy and adjuvant chemotherapy with carboplatin remains an option in men not suitable for surveillance. Clinical stage IIA/B and IIC are treated by radiation therapy and by systemic chemotherapy following orchidectomy. Clinical stage I non-seminomas are either treated by active surveillance or by one cycle of adjuvant PEB chemotherapy. Clinical stages IIA-C and advanced stages of GCT are treated by 3-4 cycles of PEB chemotherapy depending on IGCCC risk profile. Relapsing cases should be treated at tertiary referral centres only.

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