Bibliographies thématiques / Synthetic Oligomers

Littérature scientifique sur le sujet « Synthetic Oligomers »

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Publié le 6 septembre 2023

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Articles de revues sur le sujet "Synthetic Oligomers"

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Bazaco, Raúl Blanco, José L. Segura et Carlos Seoane. « Recent advances in the design, synthesis and study of covalent conjugated oligomer–C60 ensembles ». Collection of Czechoslovak Chemical Communications 74, no 6 (2009) : 857–86. http://dx.doi.org/10.1135/cccc2008218.

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This review presents an overview of the most recent results in the field of conjugated oligomer covalently attached to the C60 sphere focusing mainly on donor–conjugated oligomer–C60 triads and conjugated oligomer–multifullerene materials. Well-defined monodisperse oligomers as new materials that exhibit interesting optoelectronic properties have been the subject of intense study during the last decade. In this regard, a huge amount of work has been devoted to the development of new synthetic strategies toward the synthesis of conjugated oligomeric materials with precise length and constitution and to their chemical functionalization in order to incorporate them into more complex molecular and supramolecular architectures. An important area of research in the field of conjugated oligomers involves the design and synthesis of donor–acceptor ensembles by combination of monodisperse π-conjugated oligomeric systems with C60 fullerene. Such hybrid systems have shown excited-state interactions making them excellent candidates for fundamental photophysical studies. In addition, these materials have found applications in the field of photovoltaic devices. A review with 70 references.
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Kayama, Kotetsu, Hibiki Hashizume, Gerry Amor Camer et Daiji Endoh. « An improved gene synthesis method with asymmetric directions of oligonucleotides designed using a simulation program ». BioTechniques 69, no 3 (septembre 2020) : 211–19. http://dx.doi.org/10.2144/btn-2020-0062.

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Artificial gene synthesis based on oligonucleotide augmentation is known as overlap extension PCR which generates a variety of intermediate synthetic products. The orientation and concentration of oligomers can be adjusted to reduce the synthesis of intermediates and optimize the full-length process of DNA synthesis, using a simulation program for serial oligomer extension. The efficiency of the serial oligomer extension process is predicted to be greatest when oligomers are in a ‘forward-reverse-reverse-reverse’ direction. Oligomers with such designed directions demonstrated generation of the desired product in the shortest time (number of cycles) by repeated annealing and elongation. This method, named Asymmetric Extension supported by a Simulator for Oligonucleotide Extension (AESOE), has shown efficiency and effectiveness with potentials for future improvements and optimal usage in DNA synthesis.
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Ali, Dildar, Zaheer Ahmed, Peter M. Kazmaier et Erwin Buncel. « Synthesis and characterization of low-molecular-weight azo-acetoxystyrene and azo-naphthalene oligomers via stable free radical polymerization (SFRP) ». Canadian Journal of Chemistry 88, no 9 (septembre 2010) : 910–21. http://dx.doi.org/10.1139/v10-072.

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As an approach toward controlled molecular architecture through stable free radical polymerization (SFRP), we have prepared a series of oligomers of controlled molecular weights (Mn) and low polydispersities (structures 2 and 3, with n values ranging from 2 to 52). Definitive evidence of structure was obtained through MALDI/MS (inter-peak interval of 162 m/z in azo-acetoxystyrene oligomers 2 and 260 m/z in azo-naphthalene oligomers 3, which correspond to the acetoxystyrene (AS) and naphthalenic (Np) repeating units, with corroborative evidence from NMR and GPC. Two synthetic pathways were explored. Pathway 1 yields azo-acetoxystyrene oligomer 2 via SFR addition of a TEMPO-capped unimer 1 to acetoxystyrene. Subsequent reactions would convert 2 into 3. In an alternative pathway 2, SFR addition of 1 to 4-(1-methoxynaphthyl)styrene gives azo-naphthalene oligomer 3 directly. Thus, the present reported methodology for controlled architecture has achieved synthesis of oligomers from low Mn (chlorobenzene, PhCl, solvent) to relatively high Mn (bulk), with incorporation of naphthyl (donor) and azobenzene (acceptor) moieties, as well as spacer moieties, in a controlled manner.
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Pils, Marlene, Alexandra Dybala, Fabian Rehn, Lara Blömeke, Tuyen Bujnicki, Victoria Kraemer-Schulien, Wolfgang Hoyer, Detlev Riesner, Dieter Willbold et Oliver Bannach. « Development and Implementation of an Internal Quality Control Sample to Standardize Oligomer-Based Diagnostics of Alzheimer’s Disease ». Diagnostics 13, no 10 (11 mai 2023) : 1702. http://dx.doi.org/10.3390/diagnostics13101702.

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Protein misfolding and aggregation are pathological hallmarks of various neurodegenerative diseases. In Alzheimer’s disease (AD), soluble and toxic amyloid-β (Aβ) oligomers are biomarker candidates for diagnostics and drug development. However, accurate quantification of Aβ oligomers in bodily fluids is challenging because extreme sensitivity and specificity are required. We previously introduced surface-based fluorescence intensity distribution analysis (sFIDA) with single-particle sensitivity. In this report, a preparation protocol for a synthetic Aβ oligomer sample was developed. This sample was used for internal quality control (IQC) to improve standardization, quality assurance, and routine application of oligomer-based diagnostic methods. We established an aggregation protocol for Aβ1–42, characterized the oligomers by atomic force microscopy (AFM), and assessed their application in sFIDA. Globular-shaped oligomers with a median size of 2.67 nm were detected by AFM, and sFIDA analysis of the Aβ1–42 oligomers yielded a femtomolar detection limit with high assay selectivity and dilution linearity over 5 log units. Lastly, we implemented a Shewhart chart for monitoring IQC performance over time, which is another important step toward quality assurance of oligomer-based diagnostic methods.
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Orlov, Y. N. « The impact of the of cationic polyelectrolyte polymerization degree in latexes coagulation dosage of synthetic emulsion rubbers ». Proceedings of the Voronezh State University of Engineering Technologies 81, no 1 (18 juillet 2019) : 318–24. http://dx.doi.org/10.20914/2310-1202-2019-1-318-324.

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The literature data on the parameters of coagulation of butadiene-styrene and butadiene-?-methyl styrene latexes by cationic polyelectrolytes in comparison with low-molecular ammonium compounds and nonionic polymers are discussed. The optimal dosage of cationic polyelectrolyte during coagulation of synthetic emulsion rubber latex stabilized by a combination of synthetic fatty acid Soaps and disproportionated rosin with a mixture of sodium salts of the oligomeric condensation product ?-naphthalenesulfonic acid with formaldehyde (Leukanol) is determined, ceteris paribus, by its degree of polymerization. The decrease in the optimum dosage during the transition from high molecular weight polyelectrolytes to the oligomers caused by decrease of the cationic and anionic groups ratio required for a complete binding Leukanol in the formation of oligomer-oligomer complexes compared with the polymer-oligomer complexes. This is due, apparently, the fact that an increase in the average molecular weight of the polyelectrolyte increases the proportion of so-called tails and loops, consisting of units of the polyelectrolyte that are not associated with molecules Leukanol
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Mao, Jialin, Wei Zhang, Stephen ZD Cheng et Chrys Wesdemiotis. « Analysis of monodisperse, sequence-defined, and POSS-functionalized polyester copolymers by MALDI tandem mass spectrometry ». European Journal of Mass Spectrometry 25, no 1 (février 2019) : 164–74. http://dx.doi.org/10.1177/1469066719828875.

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Monodisperse, sequence-defined polymers can be potentially used for digital data storage. This study reports the sequence analysis and differentiation of monodisperse polyester copolymers carrying side chains functionalized in a specific order by polyhedral oligomeric silsesquioxane (POSS) nanoparticles. Steglich esterification and succinic anhydride ring-opening chemistries were utilized iteratively to synthesize the intended sequences, which were characterized by matrix-assisted laser desorption ionization tandem mass spectrometry (MALDI-MS2). Isomeric oligomers were readily distinguished based on their different fragmentation patterns. The sequences embedded in the oligomers were decrypted by their specific backbone dissociation pathways. The robustness of using MALDI-MS2 as a sequencing method for monodisperse synthetic macromolecules was assessed and validated by the characterization of longer oligomers.
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Walsh, D. M., I. Klyubin, G. M. Shankar, M. Townsend, J. V. Fadeeva, V. Betts, M. B. Podlisny et al. « The role of cell-derived oligomers of Aβ in Alzheimer's disease and avenues for therapeutic intervention ». Biochemical Society Transactions 33, no 5 (26 octobre 2005) : 1087–90. http://dx.doi.org/10.1042/bst0331087.

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Burgeoning evidence suggests that soluble oligomers of Aβ (amyloid β-protein) are the earliest effectors of synaptic compromise in Alzheimer's disease. Whereas most other investigators have employed synthetic Aβ peptides, we have taken advantage of a β-amyloid precursor protein-overexpressing cell line (referred to as 7PA2) that secretes sub-nanomolar levels of low-n oligomers of Aβ. These are composed of heterogeneous Aβ peptides that migrate on SDS/PAGE as dimers, trimers and tetramers. When injected into the lateral ventricle of rats in vivo, these soluble oligomers inhibit hippocampal long-term potentiation and alter the memory of a complex learned behaviour. Biochemical manipulation of 7PA2 medium including immunodepletion with Aβ-specific antibodies and fractionation by size-exclusion chromatography allowed us to unambiguously attribute these effects to low-n oligomers. Using this paradigm we have tested compounds directed at three prominent amyloid-based therapeutic targets: inhibition of the secretases responsible for Aβ production, inhibition of Aβ aggregation and immunization against Aβ. In each case, compounds capable of reducing oligomer production or antibodies that avidly bind Aβ oligomers also ameliorate the synaptotoxic effects of these natural, cell-derived oligomers.
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Urrego-Riveros, Sara, Matthias Bremer, Jonas Hoffmann, Anne Heitmann, Thibault Reynaldo, Janek Buhl, Paul J. Gates et al. « Conjugated oligomers with alternating heterocycles from a single monomer : synthesis and demonstration of electroluminescence ». Organic Chemistry Frontiers 6, no 21 (2019) : 3636–43. http://dx.doi.org/10.1039/c9qo00947g.

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Núñez-Villanueva, Diego, et Christopher A. Hunter. « Controlled mutation in the replication of synthetic oligomers ». Chemical Science 12, no 11 (2021) : 4063–68. http://dx.doi.org/10.1039/d0sc06770a.

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The use of two different covalent base-pairs introduces sequence mutations at a controlled rate in the covalent template-directed synthesis of oligotriazoles, a step towards evolvable synthetic polymers.
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Bianco, Alberto. « ChemInform Abstract : Combinatorial Synthetic Oligomers ». ChemInform 32, no 41 (24 mai 2010) : no. http://dx.doi.org/10.1002/chin.200141275.

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Thèses sur le sujet "Synthetic Oligomers"

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Szczypiński, Filip Tomasz. « Ester-based synthetic information oligomers ». Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289396.

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Stross, Alexander. « Synthetic H-bonding information oligomers ». Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12365/.

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The nucleic acids contain chemical information in the form of a sequence of bases. This information content is expressed through sequence selective duplex formation and template directed synthesis. To date, the only programmable artificial information molecules that can truly rival the nucleic acids, in terms of their function, are structurally very similar to the nucleic acids. This thesis describes a synthetic approach to duplex forming hydrogen bonding oligomers that contain information in the form of a sequence of H-bond donor and acceptor groups, in the pursuit of a programmable material that is orthogonal to the nucleic acids. Chapter 1 is a literature review of natural and synthetic information molecules and their applications in nanotechnology, including an overview of the structurally reengineered versions of the nucleic acids, foldamers, template polymerisation and synthetic duplexes. The review highlights the absence of totally synthetic information oligomers, that are orthogonal to the nucleic acids, and Chapter 2 sets out the aims of this thesis, which is to address this gap. Chapter 3 describes the synthesis of oligomers equipped with phenol H-bond donors and phosphine oxide H-bond acceptors. Through cooperative H-bond formation, these oligomers form double stranded complexes, which were characterised by NMR titrations and thermal denaturation experiments. For each additional H-bond there is an order of magnitude increase in association constant. In Chapter 4 it is demonstrated that the modular design for the oligomers in Chapter 3 represents a general strategy to synthetic information oligomers. Two new classes of H-bond acceptor oligomer were synthesised, bearing pyridine and pyridine N-oxide groups. Both these systems also exhibit cooperative duplex formation with H-bond donor oligomers, which were characterised by NMR titration. Chapter 5 examines the ability of mixed sequence 3-mers formed of H-bond donors (phenol) and H-bond acceptors (pyridine N-oxide) to form duplexes in a sequence selective manner. All 8 combinations of donor and acceptor were synthesised, and NMR titrations were used to measure the association constants for each pairwise combination of oligomers. Sequence matched duplexes generally have the highest association constants, but there are some anomalies.
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Swain, Jonathan. « Phenylacetylene oligomers as synthetic information molecules ». Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/279084.

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Nucleic acids store genetic information in the sequence of nucleobases. Through duplex formation and template directed synthesis, the information stored in nucleic acids determines their three-dimensional structure and function. Nucleic acids are essential molecules for biological processes and have been used in nanotechnology. Modified nucleic acids have been synthesised that still form duplexes and can be tolerated by enzymes, suggesting that it is possible to construct a synthetic system comparable to nucleic acids, orthogonal to nucleic acids. This thesis describes the synthesis of a new class of synthetic information molecule, characterisation of the duplex forming properties, and attempts at templated oligomerisation reactions. The new synthetic information molecule is based on the phenylacetylene oligomer framework developed by Moore and co-workers. Recognition was achieved via a base-pair that is made from a single point high affinity H-bond, with phenol as the H-bond donor (D) and phosphine oxide as the H-bond acceptor (A). The Sonogashira coupling was used to construct the phenylacetylene oligomer backbone. The AA, DD and AD 2-mers were synthesised and complementary 2-mers showed cooperative duplex formation. No intramolecular H-bonding due to folding was observed in the AD mixed 2-mer. Longer oligomers were synthesised using a method of oligomerisation and chromatographic separation by reverse-phase preparatory HPLC. Homo-oligomers up to the 7-mer were isolated and binding studies between complementary all donor, all acceptor homo-oligomers showed increasing duplex stability with each additional recognition unit in the oligomer chain. Oligomers containing both acceptor and donor recognition modules in the same chain were synthesised and NMR dilution studies were used to investigate their ability to fold. Preliminary experiments were carried out to evaluate the ability of these information molecules to template oligomerisation reactions, but when reactions were carried out at concentrations low enough for a significant template effect, no coupling reactions were observed.
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Iadevaia, Giulia. « A synthetic approach to H-bonding information oligomers ». Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6370/.

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Trinh, Thanh Tam. « Synthèse itérative supportée de macromolécules à séquences contrôlées ». Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF006/document.

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Des oligonylons et des oligo(triazole-amide)s possédant des séquences contrôlées de comonomères ont été étudiés dans cette thèse. Ces polymères ont été synthétisés par des approches itératives ne nécessitant pas l’emploi de groupes protecteurs. Les oligonylons ont été préparés par une approche de type «AA+BB», c.à.d. par couplage alterné de monomères diacides (AA) et diamines (BB) utilisés en excès. Cette approche s’est avérée possible mais a conduit à des réactions non-souhaitées de pontage intermoléculaire. Une approche plus robuste de type «AB+CD» a été utilisée pour la synthèse des oligo(triazole-amide)s. Dans ce cas, les polymères ont été obtenus par couplage chimioséléctif de monomères bi-fonctionnels de type AB (A = acide carboxylique, B = alcyne) et CD (C = amine, D = azoture). Cette méthode a permis la synthèse d’oligomères monomoléculaires. De plus, un codage moléculaire de type binaire (0, 1) a pu être créé sur ces oligomères. Cependant, cette approche itérative reste lente et limitée à de courtes séquences. Afin de simplifier le processus, une stratégie basée sur des couplages de trimères a été étudiée. Cette nouvelle approche a permis la synthèse de longues séquences codées contenant un octet moléculaire
In this thesis, iterative syntheses of sequence-controlled oligonylons and oligo(triazole-amide)s by protecting group-free approaches have been described. Oligonylons have been prepared by an «AA+BB» approach i.e. by stepwise couplings of a large excess of diacids (AA) and diamines (BB) monomers. This strategy was interesting but could not prevent the formation of bridged molecules. Therefore, an «AB+CD» strategy has been adopted for the synthesis of oligo(triazole-amide)s. In this case, the growth of oligomers was controlled by consecutive chemoselective couplings of AB (A = acid, B = alkyne) and CD (C = amine, D = azide) monomers. This approach was found to be efficient for the preparation of encoded monodisperse oligo(triazole-amide)s whose sequence is based on a binary code (0, 1). However, this iterative approach is slow and is not adapted to longer sequences. Consequently, a strategy based on trimers couplings has been developed in order to simplify the process. This new approach has enabled the synthesis of long code sequences containing a molecular byte
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Lightowler, Stephen. « Palladium-catalysed cross-coupling reactions in the synthesis of novel organic polymers and monodisperse oligomers ». Thesis, University of Hull, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342874.

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Henry, Brian Lawrence. « Novel Sulfated 4-Hydroxycinnamic Acid Oligomers as Potent Anticoagulants ». VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/1462.

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The occurrence of thrombosis in several pathophysiological conditions creates a huge need for anticoagulation therapy. Thrombin and factor Xa have been prime targets for regulation of clotting through the direct and indirect mechanism of inhibition. This work investigates chemo-enzymatically prepared oligomers of 4-hydroxycinnamic acids (DHPs) as potential anticoagulants. Oligomers were prepared through peroxidase-catalyzed oxidative coupling of 4-hydroxycinnamic acids. The products resulting from this reaction are called CDs, FDs and SDs. Structurally, these sulfated DHPs are unique and do not resemble any of the anticoagulants known in the literature.DHP oligomers were found to increase clotting times at concentrations comparable to heparin. Studies in blood and plasma show that DHPs possess an anticoagulation profile similar to enoxaparin. To understand the mechanism of action of DHPs, we studied the inhibition of thrombin, FXa, FIXa, and FVIIa in the presence and absence of antithrombin. CDs and FDs display a preference for direct inhibition of thrombin and FXa, and exhibit a high level of specificity over FIXa and FVIIa. In the presence of AT, CDs and FDs displayed weaker inhibition of FXa and thrombin suggesting that binding to AT is a competitive side reaction. SDs exhibited potent inhibition of FXa and thrombin in the absence of antithrombin, but was inactive against FIXa and FVIIa representing the best selectivity among the DHPs. For SDs, inhibition of all the pro-coagulant enzymes favored the antithrombin dependent pathway. Binding studies were performed to determine how CDs directly inhibits thrombin. Competitive binding studies suggest that CDs interacts with exosite II and disrupts the catalytic triad of thrombin. These results indicate that the preferred mechanism of CDs action is exosite II mediated allosteric disruption of thrombin. CDs appears to be the first exosite II mediated DTI and this represents a novel mechanism of inhibitor function. The inhibition characteristics of DHPs are unique and radically different in structure from all the current clinically used anticoagulants. To the best of our knowledge this dual mechanism of anticoagulation and unique binding mode has not been described as yet in literature and represents a novel strategy that our laboratory has discovered.
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Sprafke, Johannes Klaus. « Supramolecular control of synthesis and electronic structure of porphyrin oligomers ». Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:520bfa69-8cd5-4615-96fb-487651dd557a.

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The work described in this thesis demonstrates the use of supramolecular chemistry in the template-directed synthesis of porphyrin nanorings and as a tool to control conformation and topology of π-conjugated porphyrin oligomers. Particular emphasis is placed on changes to the electronic structure of these oligomers depending on their conformation. Chapter 1 gives an overview of π-conjugated porphyrin oligomers and conjugated macrocycles in general, followed by an introduction into supramolecular cooperativity and small angle X-ray scattering in solution. Chapter 2 describes advances in the synthesis, solution structure elucidation and optoelectronic properties of a fully conjugated cyclic porphyrin hexamer. The high rigidity and symmetry of this nanoring as well as its bent π-system lead to a significant decrease in its HOMO-LUMO gap. The resulting near-infrared emission was exploited in the fabrication of light emitting diodes, demonstrating the use of a bent topology for minimizing aggregation in thin films. The synthesis of a [12]porphyrin nanoring using a hexadentate template is presented in Chapter 3. The concept of Vernier templating is introduced as a general strategy for the synthesis of large monodisperse macrocycles. The nanoring is characterized and its cooperative binding to two template molecules is studied. In Chapter 4 a bidentate ligand is used in the cooperative formation of a sandwich complex beween two nanorings. Chapter 5 provides an analysis of the rigidity of the butadiyne linked porphyrin oligomers used throughout this thesis. A linear chain is significantly more flexible in solution than on a surface where it is confined within two dimensions. Analysis of the persistence length indicates that a porphyrin nanoring with more than around 20 units would not be significantly strained. The supramolecular binding of linear porphyrin oligomers to carbon nanotubes is analyzed in Chapter 6. The binding strength increases sharply with oligomer length and binding is strongest with (8,6) and (7,5) tubes. The energy level alignment in these porphyrin CNT complexes appears to be favorable for an application in photovoltaics. In Chapter 7 bisamidine-carboxylate salt bridges together with zinc-nitrogen coordination chemistry are used to access a variety of topologies in assemblies based on carboxylic acid functionalized porphyrin dimers.
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Sun, Xiaohua. « Synthesis and properties of monodisperse oligomer-substituted calix[4]arene assemblies and related oligomers ». HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/706.

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Yao, Dandan. « Synthesis of new conjugated meso porphyrin dendrimers and oligomers and study of their optical properties ». Thesis, Rennes, INSA, 2015. http://www.theses.fr/2015ISAR0008/document.

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Au cours de cette thèse, nous avons synthétisé et caractérisé de nouveaux composés en utilisant le macrocycle porphyrine en tant que brique moléculaire. L’objectif, après la synthèse, était d’étudier les propriétés photophysiques de ces nouvelles molécules. Plus précisément, nous avons considérés trois groupes de dendrimères fluorènyles-porphyrines et deux oligomères avec des structures conjuguées. Les corrélations structures et propriétés optiques ont été discutées en détail, ainsi que le transfert d’énergie du dendron conjugué donneur. Dans le premier chapitre, nous avons décrit la chimie des porphyrines en considérant surtout trois aspects: (i) structure, (ii) propriétés optiques et (iii) méthode synthétique. Nous avons également reporté les porphyrines préalablement étudiées dans notre groupe de recherche et proposé de nouveaux modèles lors de cette thèse. Dans le deuxième chapitre, nous avons étudié l’influence de la position de substitution du phényle sur le coeur central qui est la porphyrine TPP. Deux groupes de nouveaux dendrimères ont été synthétisés avec différentes positions de substitution du phényle de la TPP: série parasubstituée TPP1, TPP2 et TPP3, et série méta-substituée TPP4, TPP5 et TPP6. Ces dendrimères ont tous des dendrons conjugués avec des ponts phényl-alcynes et des groupements fluorènyles terminaux. Dans le troisième chapitre, pour étudier l’influence des antennes périphériques, une série de dendrimères de porphyrine à base de TFP avec différentes positions de fluorènyles dans les dendrons conjugués (fluorényle central, fluorényle pontant et fluorényle terminal): TFP1, TFP2 et TFP3 a été synthétisée. Le fluorényle central influence principalement l’émission et le rendement quantique, alors que le fluorényle ponté et le fluorényle terminal ont un plutôt un effet sur l’absorption et l’émission du dendron en raison du transfert d’énergie prenant effet. Pour le plus gros dendrimère TFP3, lors de l’excitation du dendron, une émission résiduelle lors du processus de transfert est observée due à une trop grande distance entre ce chromophore et le coeur de la porphyrine. Dans le quatrième chapitre, afin d’étudier l’influence des connexions dans le dendron, deux nouveaux dendrimères de porphyrine incorporant des ponts vinyles et alcynyles, TPP-D et TFP-D, ont été synthétisés et comparés aux analogues avec des ponts alcynes TPP-T et TFP-T. Ces ponts avec des doubles liaisons influencent dans une certaine mesure les propriétés optiques des dendrimères de porphyrine en fonction des positions occupées. Dans le dernier chapitre, deux oligomères (un dimère linéaire et en un trimère en étoile), ont été synthétisés à partir du même monomère de porphyrine avec TFP comme groupement terminaux
During this thesis, we have worked on the synthesis and characterization of new compounds using the porphyrin macrocycle as a starting material. The aim, after synthesis, was to study the photophysical properties of these new molecules. More precisely, we have synthesized and characterized three groups of fluorenyl-porphyrin dendrimers and two oligomers in conjugated structures. Their correlation on optical property-structure have been discussed in detail, as well as the energy transfer processes from the conjugated dendron donor to porphyrin acceptor. In the first chapter, we introduce the general background of the porphyrin chemistry based on three aspects: (i) structure, (ii) optical properties and (iii) synthetic methods. We further review prior porphyrin studies done in our group and propose new molecular designs based on these results. In the second chapter, we study the influence of substitution position and nature of the antennae on the central core. Two groups of new TPP-cored porphyrin dendrimers were synthesized according to different substituted positions on the peripheral phenyl rings: para-substituted series TPP1, TPP2 and TPP3, and meta-substituted ones TPP4, TPP5 and TPP6. All have conjugated dendrons with bridged phenyl-alkynyl and are terminated by fluorenyl groups. In the third chapter, we study the influence of positions of light absorbers. To this aim, a series of TFP-cored porphyrin dendrimers presenting fluorenyls in conjugated dendrons on different positions is reported (core fluorenyl, bridging fluorenyl and terminal fluorenyl): TFP1, TFP2 and TFP3. The core fluorenyl mainly influences emission peaks and quantum yield, while the bridging fluorenyl and terminal fluorenyl have a large effect on the dendron absorption and on the energy transfer efficiency. Thus, for the largest dendrimer TFP3, dendron emission is not totally quenched by long distance energy transfer process when exciting the peripheral dendrons. In the fourth chapter, we study the influence of linkages in the Dendron. Thus, two new porphyrin dendrimers with bridged vinyl, TPP-D and TFP-D, were synthesized and compared to analogues with alkynyl bridged TPP-T and TFP-T. Vinyl and alkynyl bridges are shown to influence the optical properties of the porphyrin dendrimers to a certain extent depending on the substituted positions. Finally, in the last chapter, two oligomers with n-butyl substituted TFP as terminal group, a linear dimer and a star – shaped trimer, were synthesized from the same porphyrin monomer
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Livres sur le sujet "Synthetic Oligomers"

1

Uglea, Constantin V. Synthesis and characterization of oligomers. Boca Raton, Fla : CRC Press, 1991.

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2

Center, Langley Research, et United States. National Aeronautics and Space Administration., dir. Synthesis and characterization of modified phenylethynyl terminated polyimides. Hampton, Va : National Aeronautics and Space Administration, Langley Research Center, 1998.

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S, Minkin Vladimir, et Deberdeev Timur R, dir. Polysulfide oligomer sealants : Synthesis, properties, and applications. Oakville, ON, Canada : Apple Academic Press, 2015.

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1942-, Pethrick R. A., Zaikov Gennadiĭ Efremovich et Pielichowski Jan, dir. Monomers, oligomers, polymers, composites and nanocomposites research : synthesis, properties and applications. Hauppauge, N.Y : Nova Science Publishers, 2009.

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Malkin, A. Ya. Rheokinetics : Rheological transformations in synthesis and reactions of oligomers and polymers. Heidelberg : Hüthig & Wepf, 1996.

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Malkin, Aleksandr I͡Akovlevich. Rheokinetics : Rheological transformations in synthesis and reactions of oligomers and polymers. Zug : Huthig & Wepf, 1996.

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Elsadig, Hwaida Misbah. Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine peptoid oligomer libraries. [Portsmouth] : [University of Portsmouth], 2000.

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Kontes, Ferenc. Strategies for the Controlled Synthesis of Oligomeric Natural Products. [New York, N.Y.?] : [publisher not identified], 2011.

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Lyet, Karine Andree. Experiments leading towards the synthesis by the solid phase method of inositol oligomers. Birmingham : University of Birmingham, 1994.

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Studies towards Selective Synthesis of Resveratrol-based Oligomeric Natural Products. [New York, N.Y.?] : [publisher not identified], 2011.

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Chapitres de livres sur le sujet "Synthetic Oligomers"

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Gray, Gary M., Keith E. Branham, Lung-Hua Ho, Jimmy W. Mays, Prakash C. Bharara, Andreas Hajipetrou et James B. Beal. « Poly(alkylene Phosphates) : Synthetic Strategies ». Dans Inorganic and Organometallic Oligomers and Polymers, 249–62. Dordrecht : Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3214-5_20.

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Ohgi, Tadaaki, et Junichi Yano. « Development of a Novel Synthetic Method for RNA Oligomers ». Dans Pharmaceutical Process Chemistry, 345–61. Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527633678.ch17.

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Sillion, Bernard. « Polymerization of Reactive Telechelic Oligomers. Formation of Thermostable Networks. » Dans Recent Advances in Mechanistic and Synthetic Aspects of Polymerization, 237–54. Dordrecht : Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3989-9_18.

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Goossens, Remko, et Annemieke Aartsma-Rus. « In Vitro Delivery of PMOs in Myoblasts by Electroporation ». Dans Methods in Molecular Biology, 191–205. New York, NY : Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_12.

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AbstractAntisense oligonucleotides (AONs) are small synthetic molecules of therapeutic interest for a variety of human disease. Their ability to bind mRNA and affect its splicing gives AONs potential use for exon skipping therapies aimed at restoring the dystrophin transcript reading frame for Duchenne muscular dystrophy (DMD) patients. The neutrally charged phosphorodiamidate morpholino oligomers (PMOs) are a stable and relatively nontoxic AON modification. To assess exon skipping efficiency in vitro, it is important to deliver them to target cells. Here, we describe a method for the delivery of PMOs to myoblasts by electroporation. The described protocol for the Amaxa 4D X unit nucleofector system allows efficient processing of 16 samples in one nucleocuvette strip, aiding in high-throughput PMO efficacy screens.
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Entelis, S. G., V. V. Evreinov, A. I. Kuzaev, V. M. Divid et Yu U. Rajabov. « Synthesis of Reactive Oligomers and the Formation of Functionally-Defective Macromolecules ». Dans Reactive Oligomers, 11–51. London : CRC Press, 2023. http://dx.doi.org/10.1201/9780429087561-3.

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Ebdon, J. R. « Terminally reactive oligomers : telechelic oligomers and macromers ». Dans New Methods of Polymer Synthesis, 162–96. Dordrecht : Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-010-9552-5_6.

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Ebdon, J. R. « Terminally reactive oligomers : telechelic oligomers and macromers ». Dans New Methods of Polymer Synthesis, 162–96. Boston, MA : Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-1530-8_6.

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Chan-Seng, Delphine, et Jean-François Lutz. « Solid-Phase Synthesis as a Tool for the Preparation of Sequence-Defined Oligomers Based on Natural Amino Acids and Synthetic Building Blocks ». Dans ACS Symposium Series, 103–16. Washington, DC : American Chemical Society, 2014. http://dx.doi.org/10.1021/bk-2014-1170.ch007.

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Saito, Nozomi. « Synthesis of Ethynylhelicene Oligomers ». Dans Springer Theses, 7–10. Tokyo : Springer Japan, 2013. http://dx.doi.org/10.1007/978-4-431-54514-9_2.

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Kudaibergenov, Sarkyt, Werner Jaeger et Andre Laschewsky. « Polymeric Betaines : Synthesis, Characterization, and Application ». Dans Supramolecular Polymers Polymeric Betains Oligomers, 157–224. Berlin, Heidelberg : Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/12_078.

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Actes de conférences sur le sujet "Synthetic Oligomers"

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Kim, Y. H., F. Li et H. Zimmer. « Charged states of thiophene oligomers ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.834786.

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Poplawski, J., E. Ehrenfreund, R. Pugh, M. Ibrahim, A. J. Frank, J. Cornil et J. L. Bredas. « Photogeneration of polarons in sexithiophene oligomers ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.834699.

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Matsuda, N., T. Shimura, K. Aramaki et H. Nishihara. « Synthesis of soluble cobaltacyclopentadiene oligomers and polymers ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835311.

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Robins, K. A., S. J. Kim, J. L. Toto, M. Hasan, T. T. Toto, C. P. de Melo et B. Kirtman. « Ab-initio nonlinear optical properties of finite polyacetylene oligomers ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.836119.

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Fichou, D., J. M. Nunzi, F. Charra et N. Pfeffer. « Molecular engineering of thiophene oligomers for efficient spatial light modulation ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835674.

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de Leeuw, D. M., et E. J. Lous. « Metal-insulator-semiconductor Schottky-type diodes of doped thiophene oligomers ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.836009.

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Graupner, W., S. Eder, M. Mauri, G. Leising, W. Fischer et F. Stelzer. « Excited states in conjugated polymers and oligomers probed by photinduced absorption ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835200.

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Xjangli Wu, J. P. Parakka, Yeon-Taik Kim, M. P. Cava et R. M. Metzger. « Molecular ordering in scanning tunneling micrographs of thiophene-alkylpyrrole oligomers on graphite ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835399.

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Cornil, J., D. A. dos Santos, D. Beljonne, R. Lazzaroni et U. Bredas. « Theoretical investigation of the electronic structure of donor/acceptor substituted phenylene vinylene oligomers ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835221.

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Underhill, A. E., C. A. S. Hill, A. Charlton, S. Oliver et S. Kershami. « Third order NLO properties of PMMA films co-dispersed with metal dithiolene oligomers ». Dans International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835741.

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Rapports d'organisations sur le sujet "Synthetic Oligomers"

1

Feng, J., W. Zhang, A. G. MacDiarmid et A. J. Epstein. Synthesis and Characterization of Oligomeric Anilines. Fort Belvoir, VA : Defense Technical Information Center, septembre 1997. http://dx.doi.org/10.21236/ada330138.

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Freeman, J. In vitro synthesis and purification of PhIP-deoxyguanosine and PhIP-DNA oligomer covalent complexes. Office of Scientific and Technical Information (OSTI), décembre 1994. http://dx.doi.org/10.2172/98639.

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Stone, Rebecca L., Joseph M. Mabry et Timothy S. Haddad. Synthesis and Characterization of Long-Chain Fluorinated Polyhedral Oligomeric Silsesquioxane (F-POSS). Fort Belvoir, VA : Defense Technical Information Center, octobre 2010. http://dx.doi.org/10.21236/ada533419.

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