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Littérature scientifique sur le sujet « SYNTHESIS, BIOMATERIAL, PEPTIDE, CARBOHYDRATE »

Auteur : Grafiati
Publié le 9 mars 2023
Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "SYNTHESIS, BIOMATERIAL, PEPTIDE, CARBOHYDRATE"

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Wartchow, Charles A., Peng Wang, Mark D. Bednarski et Matthew R. Callstrom. « Carbohydrate Protease Conjugates : Stabilized Proteases for Peptide Synthesis ». Journal of Organic Chemistry 60, no 7 (avril 1995) : 2216–26. http://dx.doi.org/10.1021/jo00112a049.

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Hossain, Farzana, Shruthi Kandalai, Xiaozhuang Zhou, Nan Zhang et Qingfei Zheng. « Chemical and Synthetic Biology Approaches for Cancer Vaccine Development ». Molecules 27, no 20 (16 octobre 2022) : 6933. http://dx.doi.org/10.3390/molecules27206933.

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Cancer vaccines have been considered promising therapeutic strategies and are often constructed from whole cells, attenuated pathogens, carbohydrates, peptides, nucleic acids, etc. However, the use of whole organisms or pathogens can elicit unwanted immune responses arising from unforeseen reactions to the vaccine components. On the other hand, synthetic vaccines, which contain antigens that are conjugated, often with carrier proteins, can overcome these issues. Therefore, in this review we have highlighted the synthetic approaches and discussed several bioconjugation strategies for developing antigen-based cancer vaccines. In addition, the major synthetic biology approaches that were used to develop genetically modified cancer vaccines and their progress in clinical research are summarized here. Furthermore, to boost the immune responses of any vaccines, the addition of suitable adjuvants and a proper delivery system are essential. Hence, this review also mentions the synthesis of adjuvants and utilization of biomaterial scaffolds, which may facilitate the design of future cancer vaccines.
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Herzner, Holger, Tanja Reipen, Michael Schultz et Horst Kunz. « Synthesis of Glycopeptides Containing Carbohydrate and Peptide Recognition Motifs ». Chemical Reviews 100, no 12 (décembre 2000) : 4495–538. http://dx.doi.org/10.1021/cr990308c.

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Badhe, Ravindra, Pradeep Kumar, Yahya Choonara, Thashree Marimuthu, Lisa du Toit, Divya Bijukumar, Dharmesh Chejara, Mostafa Mabrouk et Viness Pillay. « Customized Peptide Biomaterial Synthesis via an Environment-Reliant Auto-Programmer Stigmergic Approach ». Materials 11, no 4 (16 avril 2018) : 609. http://dx.doi.org/10.3390/ma11040609.

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Bini, Davide, Laura Russo, Chiara Battocchio, Antonino Natalello, Giovanni Polzonetti, Silvia Maria Doglia, Francesco Nicotra et Laura Cipolla. « Dendron Synthesis and Carbohydrate Immobilization on a Biomaterial Surface by a Double-Click Reaction ». Organic Letters 16, no 5 (19 février 2014) : 1298–301. http://dx.doi.org/10.1021/ol403476z.

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Racheva, M., O. Romero, K. K. Julich-Gruner, A. S. Ulrich, C. Wischke et A. Lendlein. « Purity of mushroom tyrosinase as a biocatalyst for biomaterial synthesis affects the stability of therapeutic peptides ». MRS Proceedings 1718 (2015) : 85–90. http://dx.doi.org/10.1557/opl.2015.260.

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ABSTRACTThe formation of injectable implants in the presence of cells or solutes has previously been conceptualized to be based on the selectivity of bioorthogonal chemical reactions. As an alternative approach, hydrogel network synthesis by enzymatic reactions with a typically high inherent substrate specificity and low toxicity have been repeatedly proposed, e.g. using commercial mushroom tyrosinase (MTyr), which specifically catalyzes phenol oxidation. In this study, it should be explored whether MTyr is compatible with therapeutic peptides that may be delivered from such hydrogels in the future. Based on the specificity of MTyr to phenol residues, no modification of peptides lacking the amino acid tyrosine would be expected. One example of such peptides is gramicidin S (GS), a potent antimicrobial peptide. However, when GS was incubated with commercial MTyr, peptide degradation occurred as observed by HPLC analysis. Several fragments of the peptide were detected by MALDI-TOF. Contamination of MTyr with peptidases was proven as the source of undesired peptide cleavage, which needs to be considered when preparing enzymatically crosslinked hydrogels for biomedical applications.
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Herzner, Holger, Tanja Reipen, Michael Schultz et Horst Kunz. « ChemInform Abstract : Synthesis of Glycopeptides Containing Carbohydrate and Peptide Recognition Motifs ». ChemInform 32, no 9 (27 février 2001) : no. http://dx.doi.org/10.1002/chin.200109270.

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Fernandes, Rafaella F., Giordano T. Paganoto et Marcia L. A. Temperini. « Non-traditional intrinsic luminescence from non-conjugated polymer dots : designing a hybrid biomaterial ». Polymer Chemistry 12, no 43 (2021) : 6319–28. http://dx.doi.org/10.1039/d1py01104a.

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Herein, an eco-friendly and facile synthesis of nitrogen-containing non-conjugated polymer dots (NCPD) with optimal blue emission is reported from the biopolymer β-glucan with a peptide–polysaccharide linkage (namely NH2-β-glucan).
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Wu, Fang-Yi, et Hsin-Chieh Lin. « Synthesis, Self-Assembly, and Cell Responses of Aromatic IKVAV Peptide Amphiphiles ». Molecules 27, no 13 (27 juin 2022) : 4115. http://dx.doi.org/10.3390/molecules27134115.

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Synthetic bioactive aromatic peptide amphiphiles have been recognized as key elements of emerging biomedical strategies due to their biocompatibility, design flexibility, and functionality. Inspired by natural proteins, we synthesized two supramolecular materials of phenyl-capped Ile-Lys-Val-Ala-Val (Ben-IKVAV) and perfluorophenyl-capped Ile-Lys-Val-Ala-Val (PFB-IKVAV). We employed UV-vis absorption, fluorescence, circular dichroism, and Fourier-transform infrared spectroscopy to examine the driving force in the self-assembly of the newly discovered materials. It was found that both compounds exhibited ordered π-π interactions and secondary structures, especially PFB-IKVAV. The cytotoxicity of human mesenchymal stem cells (hMSCs) and cell differentiation studies was also performed. In addition, the immunofluorescent staining for neuronal-specific markers of MAP2 was 4.6 times (neural induction medium in the presence of PFB-IKVAV) that of the neural induction medium (control) on day 7. From analyzing the expression of neuronal-specific markers in hMSCs, it can be concluded that PFB-IKVAV may be a potential supramolecular biomaterial for biomedical applications.
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Zhong, Wei, Mariusz Skwarczynski, Yoshio Fujita, Pavla Simerska, Michael F. Good et Istvan Toth. « Design and Synthesis of Lipopeptide - Carbohydrate Assembled Multivalent Vaccine Candidates Using Native Chemical Ligation ». Australian Journal of Chemistry 62, no 9 (2009) : 993. http://dx.doi.org/10.1071/ch09065.

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Development of a synthetic vaccine against group A streptococcal infection is increasingly paramount due to the induction of autoimmunity by the main virulent factor – M protein. Peptide vaccines, however, are generally poorly immunogenic, necessitating administration with carriers and adjuvants. One of the promising approaches to deliver antigenic peptides is to assemble peptides on a suitable template which directs the attached peptides to form a well defined tertiary structure. For self-adjuvanting human vaccines, the conjugation of immunostimulatory lipids has been demonstrated as a potentially safe method. This study describes the design and optimized synthesis of two lipopeptide conjugated carbohydrate templates and the assembling of peptide antigens. These lipopeptide–carbohydrate assembled multivalent vaccine candidates were obtained in high yield and purity when native chemical ligation was applied. Circular dichroism studies indicated that the template-assembled peptides form four α-helix bundles. The developed technique extends the use of carbohydrate templates and lipopeptide conjugates for producing self-adjuvanting and topology-controlled vaccine candidates.
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Thèses sur le sujet "SYNTHESIS, BIOMATERIAL, PEPTIDE, CARBOHYDRATE"

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SHAIKH, NASRIN ISMAIL. « "Design and synthesis of relevant biomolecules for functionalization of biomaterial in tissue engineering" ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19453.

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Carbohydrates, glycoconjugates, and oligosaccharides are critical components of living systems and mediate a vast number of fundamental biological processes from complex cellular operations required to initiate and sustain life, to recognition events that are responsible for autoimmune diseases, organ rejection, and inflammation. This functional diversity is reflected in the diversity of carbohydrate structures. There is an increasing demand for efficient access to oligosaccharides and glycoconjugates to deepen our understanding of glycobiology and to expedite the development of therapeutic agents. Biomaterials science brings together researchers from diverse academic backgrounds. They must communicate clearly. Some disciplines that intersect in the development, study and application of biomaterials include: bioengineer, chemist, chemical engineer, electrical engineer, mechanical engineer, materials scientist, biologist, microbiologist, physician, veterinarian, ethicist, nurse, lawyer, regulatory specialist and venture capitalist. Bone tissue engineering has become a significant area of research, and as a result of emerging activity in this field, a new class of drugs has been introduced with excellent potential to stimulate bone formation and to induce new bone regeneration. Biodegradable scaffolds should ideally provide the initial strength required to resist blood flow, and then gradually degrade to leave a graft composed solely of host tissue.
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Wartchow, Charles Aaron. « Carbohydrate protease conjugates (CPC) : stabilized proteases for peptide synthesis / ». The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487847309050511.

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GABRIELLI, LUCA. « Glycomimetics : design, synthesis and biological activity studies ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41953.

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My PhD project has been focused on the design, synthesis and biological activity studies of glicomimetics. During these three years I have been mainly interested in three different arguments (three proteins: API, Akt, CIM6Pr) that I will elucidate in detail in this thesis. Even if the target proteins (enzymes and receptors) are very different, these three arguments have a common element. In all cases, starting from the known mechanistic, structural and biological information of the single protein, I have designed glycomimetics that are potentially able to interact with the target protein. All the studied proteins are biologically relevant, so the final aim of the synthetic effort is always a biological test, in order to check the hypothesis done during the design step and to get new useful information about the biological system. The synthesized compounds are always glycomimetics or, more generally speaking, glycans: they can be arabinose-based mimetic of A5P, glucose-based mimetic of an inisitol structure, or synthetic glycoproteins. The most used analytical instrument for the characterization of all the synthesized compounds and for the study of their interaction with enzymes is NMR spectroscopy. The wide use of this analytical technique led me to study topics that were not related to carbohydrates themselves, but related to NMR techniques. Therefore, I increased my knowledge and applied NMR spectroscopy to the biomaterial field and in particular I have studied the reactivity of reaction systems widely used for biomaterial production using NMR. I will briefly discuss these works in the last part of my thesis.
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Vartak, Abhishek R. « Synthesis and Evaluation of Multi-component Immuno-therapeutics Containing Peptide and Carbohydrate-based Antigens ». University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1560356357892348.

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Voglmeir, Josef. « Expression of Peptide- and Glycopeptide Modifying Glycosyltransferases for Applications in Liquid- and Solid Phase Carbohydrate Synthesis ». Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508597.

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Jiménez-Castells, Carmen 1982. « Capture and identification of carbohydrate-binding proteins by SPR and CREDEX-MS ». Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7237.

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Carbohydrate-binding proteins of non-immunological origin -lectins- have been recognized over the last decades as decisive players in numerous biological processes, ranging from cellcell communication, fertilization, pathogen-cell adhesion to metastasis. Consequently, there is an increasing interest in finding powerful and nanosized tools to screen for these molecules and to study their carbohydrate interactions in detail. Here, two complementary approaches are described to characterize lectin-carbohydrate interactions with high sensitivity, low sample consumption, and without the need for sample labelling: SPR and CREDEX-MS. In SPR, we have developed an approach where the sugar is immobilized onto a sensor surface through a tailor-made peptide module that allows (1) to capture the lectin, (2) to characterize the interaction through kinetic and thermodynamic parameters, and (3) to identify the interacted protein by mass spectrometry. In CREDEX-MS, based on proteolytic excision of proteincarbohydrate complexes and mass spectrometric analysis, the peptides comforming the carbohydrate binding domain are identified.
Las lectinas (proteínas de origen no inmune capaces de reconocer azúcares) se han revelado en las últimas décadas como participantes cruciales en multitud de procesos biológicos, tales como la comunicación célula-célula, la fertilización, la adhesión del patógeno a la célula y la metástasis, entre muchos otros. Por lo tanto, existe un gran interés en el desarrollo de técnicas analíticas potentes para el estudio de las interacciones lectina-carbohidrato. En este trabajo, se describen dos aproximaciones complementarias mediante las cuales se pueden caracterizar las interacciones lectinas-azúcar con gran sensibilidad, poca utilización de muestra y sin la necesitad de ningún marcaje. En la técnica basada en resonancia de plasmón superficial (SPR), el azúcar es inmovilizado sobre una superficie a través de un módulo peptídico, lo cual permite (1) capturar la lectina, (2) caracterizar su interacción mediante parámetros cinéticos y termodinámicos y (3) identificar posteriormente la proteína mediante espectrometría de masas. Complementariamente, la técnica CREDEX-MS, basada en la excisión proteolítica del complejo proteína-azúcar y posterior análisis por espectrometría de masas, nos permite identificar los péptidos que forman parte del dominio de unión al azúcar.
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Huang, Shun-Chiang, et 黃舜強. « Synthesis and analysis of self-assembly peptide supramolecular hydrogel biomaterial conjugated with gold nanoparticles ». Thesis, 2013. http://ndltd.ncl.edu.tw/handle/34199658716970636965.

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碩士
國立交通大學
材料科學與工程學系奈米科技碩博士班
101
Recently, development of hydrogel nanocomposites offered tremendous scope for future biomaterial applications, including bioanalysis, chemical sensing, and drug delivery. Smart combinations of different nanostructured materials supported the development of multifunctional nanomaterials. In this study, synthesizing self-assembly peptide supramolecular hydrogel 2-Naphthylacetic acid- L-Phenylalanine- L-Phenylalanine- L-Cysteine (NapFFC) has been done and conjugated with gold nanoparticles (AuNPs) as a new and potential composite material. Finding stimuli-response properties for critical hydrogelation conditions such as concentration, pH, ionic strength, temperature, and incubation time were defined by visual. Further discussion for protection ability resulted from interaction between NapFFC and AuNPs was analyzed, and the results showed hydrogel and nanoparticles were complementary materials. Fibrous network and various kinds of helix structure resulted from self-assembly molecule blocks was observed and analyzed. Fluorescence intensity emitted at 335 nm was also helpful to obtain concentration of NapFFC under 60 μM within which self-quenching didn’t occur. Utilizing fluorescence quenching effect of AuNPs was quite sensitive and precise to measure the accurate amounts of molecules bound to the surface of AuNPs. This method was also used to detect quenching effectiveness of mercury ions in this study. Moreover, cell viability showed good biocompatibility. These analysis and results of composite material were attractive feature for exploitation in the field of biomaterials.
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Chapitres de livres sur le sujet "SYNTHESIS, BIOMATERIAL, PEPTIDE, CARBOHYDRATE"

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Kihlberg, Jan, Mikael Elofsson et Lourdes A. Salvador. « [11] Direct synthesis of glycosylated amino acids from carbohydrate peracetates and Fmoc amino acids : Solid-phase synthesis of biomedicinally interesting glycopeptides ». Dans Solid-Phase Peptide Synthesis, 221–45. Elsevier, 1997. http://dx.doi.org/10.1016/s0076-6879(97)89050-7.

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Fields, Gregg B., et Janelle L. Lauer-Fields. « Principles and Practice of Solid-Phase Peptide Synthesis ». Dans Synthetic Peptides. Oxford University Press, 2002. http://dx.doi.org/10.1093/oso/9780195132618.003.0006.

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Peptides play key structural and functional roles in biochemistry, pharmacology, and neurobiology, and are important probes for research in enzymology, immunology, and molecular biology. The amino acid building blocks can be among the 20 genetically encoded L-residues, or else unusual ones, and the sequences can be linear, cyclic, or branched. It follows that rapid, efficient, and reliable methodology for the chemical synthesis of these molecules is of utmost interest. A number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the sweet dipeptide L-Asp-L-Phe-OMe (aspartame) to clinically used hormones such as oxytocin, adrenocorticotropic hormone, calcitonin, and gonadotropin releasing hormone (GnRH) super-agonists. Synthesis can lead to potent and selective new drugs by judicious substitutions that change functional groups and/or conformations of the parent peptide. These include introduction of N- or C-alkyl substituents, unnatural or D-amino acids, side-chain modifications including sulfate or phosphate groups or carbohydrate moieties, and constraints such as disulfide bridges between half-cystines or side-chain lactams between Lys and Asp or Glu. Commercially important products that evolved from such studies include protease inhibitors, such as captopril and other angiotensin converting enzyme (ACE) inhibitors, peptidomimetic HIV protease inhibitors, and the somatostatin analog lanreotide. Most of the biologically or medicinally important peptides which are the targets for useful structure-function studies by chemical synthesis comprise under 50 amino acid residues, but occasionally a synthetic approach can lead to important conclusions about small proteins (full or domains) in the 100-200 residue size range. Methods for synthesizing peptides are divided conveniently into two categories: solution (classical) and solid-phase pep tide synthesis (SPPS). The classical methods have evolved since the beginning of the twentieth century, and they are described amply in several reviews and books (Wünsch, 1974; Finn and Hofmann, 1976; Bodanszky and Bodanszky, 1984; Goodman et al, 2001). The solid-phase alternative was conceived and elaborated by R. B. Merrifield beginning in 1959, and has also been covered comprehensively (Erickson and Merrifield, 1976; Birr, 1978; Barany and Merrifield, 1979; Stewart and Young, 1984; Merrifield, 1986; Barany et al., 1987, 1988; Kent, 1988; Atherton and Sheppard, 1989; Fields and Noble, 1990; Barany and Albericio, 1991; Fields et al., 1992; Gutte, 1995; Fields, 1997; Lloyd-Williams et al., 1997; Chan and White, 2000; Kates and Albericio, 2000).
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Actes de conférences sur le sujet "SYNTHESIS, BIOMATERIAL, PEPTIDE, CARBOHYDRATE"

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Ajisaka, Katsumi, Chikako Ito et Syuichi Oka. « CHEMOENZYMATIC SYNTHESIS OF SIALYL T-ANTIGEN-LINKED PENTADECA-PEPTIDE AND ITS CHARACTERIZATION ». Dans XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.423.

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Kajimoto, Tetsuya, Toru Tanaka, Chihiro Tsuda, Tsuyoshi Miura, Toshiyuki Inazu et Shuichi Tsuji. « SYNTHESIS OF PEPTIDE MIMICS OF SUGAR NUCLEOTIDES AS THE INHIBITORS OF GLYCOSYLTRANSFERASES ». Dans XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.599.

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