Bibliographies thématiques / Synteleia

Littérature scientifique sur le sujet « Synteleia »

Auteur : Grafiati

Publié le 11 mars 2023

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Articles de revues sur le sujet "Synteleia"

Jiang, Rixin, et Shuo Wang. « Syntelia sunwukong sp. nov., the oldest Synteliid beetle (Coleoptera : Histeroidea) from mid-Cretaceous Burmese amber ». Cretaceous Research 119 (mars 2021) : 104709. http://dx.doi.org/10.1016/j.cretres.2020.104709.

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Porter, Iain M., Sarah E. McClelland, Guennadi A. Khoudoli, Christopher J. Hunter, Jens S. Andersen, Andrew D. McAinsh, J. Julian Blow et Jason R. Swedlow. « Bod1, a novel kinetochore protein required for chromosome biorientation ». Journal of Cell Biology 179, n^o 2 (15 octobre 2007) : 187–97. http://dx.doi.org/10.1083/jcb.200704098.

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We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule–kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects. Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles.

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Gaede, Kirsten. « Videobrille und Magnesium-Implantate : cdgw-Zukunftspreis für HappyMed und Syntellix ». kma - Klinik Management aktuell 21, n^o 12 (décembre 2016) : 14–15. http://dx.doi.org/10.1055/s-0036-1594341.

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Eine Videobrille, mit der Patienten während einer OP (lokalnarkotisiert) oder einer Chemotherapie Filme sehen können, und Schrauben und Pins, die im Körper vollständig abgebaut werden – diese beiden Innovationen sind in Berlin mit dem Zukunftspreis des Clubs der Gesundheitswirtschaft (cdgw) ausgezeichnet worden.

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Storchová, Zuzana, Justin S. Becker, Nicolas Talarek, Sandra Kögelsberger et David Pellman. « Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast ». Molecular Biology of the Cell 22, n^o 9 (mai 2011) : 1473–85. http://dx.doi.org/10.1091/mbc.e10-08-0673.

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The conserved mitotic kinase Bub1 performs multiple functions that are only partially characterized. Besides its role in the spindle assembly checkpoint and chromosome alignment, Bub1 is crucial for the kinetochore recruitment of multiple proteins, among them Sgo1. Both Bub1 and Sgo1 are dispensable for growth of haploid and diploid budding yeast, but they become essential in cells with higher ploidy. We find that overexpression of SGO1 partially corrects the chromosome segregation defect of bub1Δ haploid cells and restores viability to bub1Δ tetraploid cells. Using an unbiased high-copy suppressor screen, we identified two members of the chromosomal passenger complex (CPC), BIR1 (survivin) and SLI15 (INCENP, inner centromere protein), as suppressors of the growth defect of both bub1Δ and sgo1Δ tetraploids, suggesting that these mutants die due to defects in chromosome biorientation. Overexpression of BIR1 or SLI15 also complements the benomyl sensitivity of haploid bub1Δ and sgo1Δ cells. Mutants lacking SGO1 fail to biorient sister chromatids attached to the same spindle pole (syntelic attachment) after nocodazole treatment. Moreover, the sgo1Δ cells accumulate syntelic attachments in unperturbed mitoses, a defect that is partially corrected by BIR1 or SLI15 overexpression. We show that in budding yeast neither Bub1 nor Sgo1 is required for CPC localization or affects Aurora B activity. Instead we identify Sgo1 as a possible partner of Mps1, a mitotic kinase suggested to have an Aurora B–independent function in establishment of biorientation. We found that Sgo1 overexpression rescues defects caused by metaphase inactivation of Mps1 and that Mps1 is required for Sgo1 localization to the kinetochore. We propose that Bub1, Sgo1, and Mps1 facilitate chromosome biorientation independently of the Aurora B–mediated pathway at the budding yeast kinetochore and that both pathways are required for the efficient turnover of syntelic attachments.

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Yang, Zhenye, Alison E. Kenny, Daniela A. Brito et Conly L. Rieder. « Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments ». Journal of Cell Biology 186, n^o 5 (31 août 2009) : 675–84. http://dx.doi.org/10.1083/jcb.200906150.

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To determine why the duration of mitosis (DM) is less in Taxol than in nocodazole or Eg5 inhibitors we studied the relationship between Taxol concentration, the DM, and the mitotic checkpoint. We found that unlike for other spindle poisons, in Taxol the DM becomes progressively shorter as the concentration surpasses ∼0.5 µM. Studies on RPE1 and PtK2 expressing GFP/cyclin B or YFP/Mad2 revealed that cells ultimately satisfy the checkpoint in Taxol and do so faster at concentrations >0.5 µM. Inhibiting the aurora-B kinase in Taxol-treated RPE1 cells accelerates checkpoint satisfaction by stabilizing syntelic kinetochore attachments and reduces the DM to ∼1.5 h regardless of drug concentration. A similar stabilization of syntelic attachments by Taxol itself appears responsible for accelerated checkpoint satisfaction at concentrations >0.5 µM. Our results provide a novel conceptual framework for how Taxol prolongs mitosis and caution against using it in checkpoint studies. They also offer an explanation for why some cells are more sensitive to lower versus higher Taxol concentrations.

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Kline-Smith, Susan L., Alexey Khodjakov, Polla Hergert et Claire E. Walczak. « Depletion of Centromeric MCAK Leads to Chromosome Congression and Segregation Defects Due to Improper Kinetochore Attachments ». Molecular Biology of the Cell 15, n^o 3 (mars 2004) : 1146–59. http://dx.doi.org/10.1091/mbc.e03-08-0581.

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The complex behavior of chromosomes during mitosis is accomplished by precise binding and highly regulated polymerization dynamics of kinetochore microtubules. Previous studies have implicated Kin Is, unique kinesins that depolymerize microtubules, in regulating chromosome positioning. We have characterized the immunofluorescence localization of centromere-bound MCAK and found that MCAK localized to inner kinetochores during prophase but was predominantly centromeric by metaphase. Interestingly, MCAK accumulated at leading kinetochores during congression but not during segregation. We tested the consequences of MCAK disruption by injecting a centromere dominant-negative protein into prophase cells. Depletion of centromeric MCAK led to reduced centromere stretch, delayed chromosome congression, alignment defects, and severe missegregation of chromosomes. Rates of chromosome movement were unchanged, suggesting that the primary role of MCAK is not to move chromosomes. Furthermore, we found that disruption of MCAK leads to multiple kinetochore–microtubule attachment defects, including merotelic, syntelic, and combined merotelic-syntelic attachments. These findings reveal an essential role for Kin Is in prevention and/or correction of improper kinetochore–microtubule attachments.

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Hagelstein, Salome, Michael Seidenstuecker, Adalbert Kovacs, Roland Barkhoff et Sergej Zankovic. « Fixation Performance of Bioabsorbable Zn-6Ag Pins for Osteosynthesis ». Materials 15, n^o 9 (3 mai 2022) : 3280. http://dx.doi.org/10.3390/ma15093280.

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Bioabsorbable implants have become the focus of the latest research for new bone implant materials. With favorable characteristics such as compatible mechanical characteristics, no long-term side effects, and even osteogenesis enhancing properties they seem to be the future of osteosynthesis. Besides these characteristics, they must perform on the same level as traditional implant materials regarding their mechanical support for bone healing. A particular focus in the research for bioabsorbable implants has been on metal alloys, as these have particularly good mechanical properties such as excellent maximum force and high stability. This study focused on the shear strength of new bioabsorbable zinc and magnesium pins in comparison to traditional implants such as K-wires and cancellous bone screws in bone-implant connections. During quasi-static and fatigue loading experiments, magnesium pins (MAGNEZIX, Syntellix AG, Hannover, Germany) and new zinc silver pins (Zn-6Ag) by Limedion (Limedion GmbH., Mannheim, Germany) were compared with conventional osteosynthetic materials. The pins made of the new bioabsorbable alloys withstood the cyclic loads to the same extent as the conventional osteosynthesis materials. In the quasi-static loading, it was shown that the novel Zn-6Ag from Limedion has the same shear strength as the magnesium pin from Syntellix, which is already in clinical use. In addition, the zinc pin showed significantly better shear strength compared to osteosynthesis with K-wires (p < 0.05).

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Ding, Xia, Feng Yan, Phil Yao, Zhihong Yang, Weihong Wan, Xiwei Wang, Jing Liu et al. « Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin ». Cell Research 20, n^o 12 (30 novembre 2010) : 1386–89. http://dx.doi.org/10.1038/cr.2010.167.

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Liu, Xu, Leilei Xu, Junying Li, Phil Y. Yao, Wanjuan Wang, Hazrat Ismail, Haowei Wang et al. « Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly ». Journal of Molecular Cell Biology 12, n^o 8 (10 septembre 2019) : 654–65. http://dx.doi.org/10.1093/jmcb/mjz051.

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Abstract Error-free cell division depends on the accurate assembly of the spindle midzone from dynamic spindle microtubules to ensure chromatid segregation during metaphase–anaphase transition. However, the mechanism underlying the key transition from the mitotic spindle to central spindle before anaphase onset remains elusive. Given the prevalence of chromosome instability phenotype in gastric tumorigenesis, we developed a strategy to model context-dependent cell division using a combination of light sheet microscope and 3D gastric organoids. Light sheet microscopic image analyses of 3D organoids showed that CENP-E inhibited cells undergoing aberrant metaphase–anaphase transition and exhibiting chromosome segregation errors during mitosis. High-resolution real-time imaging analyses of 2D cell culture revealed that CENP-E inhibited cells undergoing central spindle splitting and chromosome instability phenotype. Using biotinylated syntelin as an affinity matrix, we found that CENP-E forms a complex with PRC1 in mitotic cells. Chemical inhibition of CENP-E in metaphase by syntelin prevented accurate central spindle assembly by perturbing temporal assembly of PRC1 to the midzone. Thus, CENP-E-mediated PRC1 assembly to the central spindle constitutes a temporal switch to organize dynamic kinetochore microtubules into stable midzone arrays. These findings reveal a previously uncharacterized role of CENP-E in temporal control of central spindle assembly. Since CENP-E is absent from yeast, we reasoned that metazoans evolved an elaborate central spindle organization machinery to ensure accurate sister chromatid segregation during anaphase and cytokinesis.

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Biber, Roland, Johannes Pauser, Markus Geßlein et Hermann Josef Bail. « Magnesium-Based Absorbable Metal Screws for Intra-Articular Fracture Fixation ». Case Reports in Orthopedics 2016 (2016) : 1–4. http://dx.doi.org/10.1155/2016/9673174.

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MAGNEZIX® (Syntellix AG, Hanover, Germany) is a biodegradable magnesium-based alloy (MgYREZr) which is currently used to manufacture bioabsorbable compression screws. To date, there are very few studies reporting on a limited number of elective foot surgeries using this innovative implant. This case report describes the application of this screw for osteochondral fracture fixation at the humeral capitulum next to a loose radial head prosthesis, which was revised at the same time. The clinical course was uneventful. Degradation of the magnesium alloy did not interfere with fracture healing. Showing an excellent clinical result and free range-of-motion, the contour of the implant was still visible in a one-year follow-up.

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Chapitres de livres sur le sujet "Synteleia"

Jensen, Sean R. « SYNTELEIA AND APOTAXIS ON THE ATHENIAN TRIBUTE LISTS ». Dans Hegemonic Finances, 55–78. The Classical Press of Wales, 2019. http://dx.doi.org/10.2307/j.ctvd58r89.7.

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« Syntelic Distribution ». Dans Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1913. Dordrecht : Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_16536.

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