Littérature scientifique sur le sujet « Sub-acute toxicity »
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Articles de revues sur le sujet "Sub-acute toxicity"
Hosseinzad, Hossein, Leila Etemad, Reza Zafari, Naser Vahdati Mashhadian, Seyed Adel Moallem et Zahra Oskouei Shirvan. « Acute, Sub-Acute and Cell Toxicity of Verbascoside ». Research Journal of Medicinal Plant 9, no 7 (1 juillet 2015) : 354–60. http://dx.doi.org/10.3923/rjmp.2015.354.360.
Texte intégralPandhare, Ramdas Bhanudas. « Assessment of Acute and 28-Day Sub-Acute Oral Toxicity of a Polyherbal Formulation in Rats ». International Journal of Pharmacognosy & ; Chinese Medicine 4, no 1 (2020) : 1–7. http://dx.doi.org/10.23880/ipcm-16000200.
Texte intégralH., Hasnisa, Syahida M. et Hadijah H. « Acute and sub-acute toxicity studies of roselle leaves ». Food Research 6, Supplementary 2 (8 décembre 2022) : 1–8. http://dx.doi.org/10.26656/fr.2017.6(s2).011.
Texte intégralMadhavan, Ramachandran. « Acute and sub acute toxicity study on Sangu parpam ». Bioinformation 17, no 1 (31 janvier 2021) : 46–52. http://dx.doi.org/10.6026/97320630017046.
Texte intégralMurugesan, S. « Acute and Sub-Acute Toxicity Studies of Linga Chenduram ». International Journal of Traditional Medicine and Applications 1, no 1 (30 janvier 2019) : 1–3. http://dx.doi.org/10.18689/ijtma-1000101.
Texte intégralKarbovskyi, V. L., I. A. Shevchuk, O. V. Kurkina et T. Ye Makovska. « Study of PEG-Filstim sub-acute toxicity ». Farmatsevtychnyi zhurnal, no 2 (14 août 2018) : 77–86. http://dx.doi.org/10.32352/0367-3057.2.17.10.
Texte intégralFalang, Kakjing, Mary Uguru et Jurbe Gotep. « Acute and Sub-acute Toxicity of HRT 123 Polyherbal Formula ». Journal of Advances in Medical and Pharmaceutical Sciences 4, no 4 (10 janvier 2015) : 1–8. http://dx.doi.org/10.9734/jamps/2015/16877.
Texte intégralPatil, Shanta, et Surekha S. Medikeri. « TOXICOLOGICAL STUDY OF SURYASHEKHARA RASA ». International Ayurvedic Medical Journal 8, no 10 (18 octobre 2020) : 4610–16. http://dx.doi.org/10.46607/iamj0708102020.
Texte intégralBalyshev, A. V., M. S. Zhuravleva, V. V. Golovin, S. V. Abramov et M. I. Slozhenkina. « Sub-acute injection toxicity of Florfenicol VS 30 ». IOP Conference Series : Earth and Environmental Science 677, no 3 (1 mars 2021) : 032080. http://dx.doi.org/10.1088/1755-1315/677/3/032080.
Texte intégralYasmeen, Sidra, Sadaf Yasmeen, Fatima Qamar, Saif Ur Rehman Khattak, Safila Naveed, Mahrukh Mughal et Halima Sadia. « Acute and Sub-Acute Toxicity of Spray-Dried Extract of Tribulus Terrestris ». Journal of Hunan University Natural Sciences 49, no 9 (30 septembre 2022) : 58–66. http://dx.doi.org/10.55463/issn.1674-2974.49.9.8.
Texte intégralThèses sur le sujet "Sub-acute toxicity"
Sibomana, Isaie. « ‘Functional Metabolomics’ Enhances Assessment of Tissue Dysfunction as Demonstrated in a Rat Model of Sub-Acute D-serine Exposure ». Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1323713109.
Texte intégralDel, Favero Giorgia. « Characterization of the risk of palytoxin and analogues as seafood contaminants ». Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7354.
Texte intégralThe present thesis was developed for the characterization of the risk associated to palytoxins as seafood contaminants. To this aim, an integrated approach between in vitro and in vivo studies was chosen. Palytoxin and its analogues are known seafood contaminants that can accumulate in several edible species of shellfish, fish, crustaceans and echinoderms. Generally, primary symptoms associated to the ingestion of contaminated food involve the gastro-intestinal apparatus and later develop with the involvement of the muscular tissue. For a better comprehension of the mechanism of action of this family of biotoxins, the effects of PLTX have been studied on primary culture of mouse skeletal muscle cells. The myotoxic insult triggered by PLTX was described in detail with the definition of the cytotoxicity together with the description of the morphologic alterations and functional impairment caused by the toxin. Moreover, the influence of the ionic composition of the extracellular medium on the effects of the toxin was elucidated. Primary cultures of skeletal muscle cells, that presents in vitro many of the peculiarities of the adult muscle fiber, allowed the investigation of the membrane mechanisms that regulate the intracellular calcium increase triggered by the toxin. It was possible to discriminate the difference between calcium release from intracellular stores and the calcium entrance from extracellular compartment both elicited by the toxin, and to understand the importance of the latter in relation to the toxic event. Moreover, the involvement of the main membrane channels and transporters that may be related to the entrance of calcium was investigated and the crucial role of stretch-activated channels in the mechanism of toxicity was demonstrated. Once defined the crucial molecular mechanisms of action of PLTX, experiments were also performed with two of its analogue: the 42-hydroxyl-palytoxin and the ostreocin-D. In parallel to in vitro studies, the effects of repeated oral administration of PLTX in mice were also investigated. In fact, in vitro studies are not sufficient for the complete comprehension of the real hazard associated to a food contaminant, since molecules once in contact with the body may undergo adsorption, distribution and metabolism before reaching the target tissue. Short-term (7 days) administration of the toxin revealed toxicity at all the doses tested and lethality was recorded in the treated animals already from the dose of 30 µg/kg. Histological analysis highlighted alterations in several tissues: severe inflammatory processes and even foci of necrosis were observed in lungs. Alteration of the muscular tissues was visible as fiber separation and degeneration in the heart and increased cellularity between fibers in skeletal muscle. Moreover, depletion of glycogen content of hepatocytes and moderate alterations of the spleen were also observed. Data collected in the present project revealed, for the first time, toxicity of PLTX at doses much lower than that currently used by European Food Safety Authority (EFSA) for the estimation of limit values for presence of these compounds in seafood. For this reason, these results are likely to have a considerable impact at regulatory level and to have crucial importance for the protection of the consumers.
Il presente lavoro di tesi è stato sviluppato con lo scopo di caratterizzare il rischio associato alla presenza delle palitossine quali contaminanti dei prodotti ittici destinati ad uso alimentare. A tal fine, è stato scelto un approccio integrato tra studi in vitro e in vivo. La palitossina e i suoi analoghi sono noti contaminanti dei prodotti ittici e possono accumularsi in diverse specie edibili di molluschi, pesci, crostacei ed echinodermi. Generalmente, i primi sintomi associati all’ingestione di cibo contaminato coinvolgono l’apparato gastro-intestinale e poi si sviluppano con l’interessamento del tessuto muscolare. Per una migliore comprensione del meccanismo d’azione di questa famiglia di biotossine, gli effetti della PLTX sono stati studiati mediante colture primarie murine di cellule muscolari scheletriche. L’insulto miotossico indotto dalla PLTX è stato descritto nel dettaglio con la definizione della citotossicità assieme alla descrizione delle modifiche morfologiche e delle alterazioni funzionali causate dalla tossina. Inoltre, è stata caratterizzata l’influenza della composizione ionica dell’ambiente extracellulare negli effetti della tossina. Le colture primarie di cellule muscolari scheletriche, che presentano molte delle caratteristiche peculiari della fibra muscolare adulta, hanno permesso l’indagine dei meccanismi che regolano l’aumento intracellulare di calcio indotto dalla tossina. E’ stato possibile discriminare la differenza tra il rilascio di calcio dai depositi intracellulari e l’entrata di calcio dai compartimenti extracellulari, entrambi effetti indotti dalla tossina, e comprendere l’importanza del secondo meccanismo in relazione agli eventi tossici. E’ stato indagato il coinvolgimento dei canali e trasportatori di membrana in relazione all’ingresso di calcio ed è stato dimostrato il ruolo cruciale dei canali attivati da stiramento nel meccanismo di tossicità. Una volta definiti i meccanismi d’azione cruciali per la PLTX, esperimenti sono stati condotti anche con due dei suoi analoghi, la 42-idrossi-palitossina e l’ostreocina-D. Parallelamente agli studi in vitro, sono stati studiati gli effetti della somministrazione orale ripetuta della PLTX nel topo. Infatti, gli studi in vitro non sono sufficienti alla comprensione del reale pericolo associato ad un contaminate alimentare, dal momento che, le molecole, una volta a contatto con l’organismo, possono subire assorbimento, distribuzione e metabolismo prima di raggiungere il tessuto bersaglio. La somministrazione a breve termine della tossina (7 giorni) ha rivelato tossicità a tutte le dosi somministrate, e letalità è stata registrata negli animali trattati già alla dose di 30 µg/kg. Le analisi istologiche hanno evidenziato alterazioni a carico di diversi tessuti: a livello polmonare sono stati osservati severi processi infiammatori associati anche a focolai di necrosi. Le alterazioni del tessuto muscolare erano visibili come degenerazione e separazione delle fibre nel cuore e aumento degli elementi cellulari tra le fibre del muscolo scheletrico. Inoltre sono stai osservati, deplezione del contenuto di glicogeno negli epatociti e moderate alterazioni della milza. I dati raccolti nel presente elaborato hanno rivelato, per la prima volta, la tossicità della palitossina a dosi molto inferiori rispetto a quelle correntemente utilizzate della European Food Safety Authority (EFSA) per la stima di valori limite per la presenza di questi composti nei prodotti ittici destinati ad uso alimentare. Per questo motivo, i risultati avranno probabilmente un considerevole impatto a livello legislativo e un’importanza cruciale per la protezione dei consumatori.
XXIV Ciclo
1984
Antunes, Adriana Maria. « Avaliação da exposição aguda e sub-letal ao glifosato (N-fosfometil-glicina) e ao AMPA (ácido amino-metil-fosfônico) em brânquias e fígado de Poecilia reticulata com o emprego de biomarcadores moleculares e morfológicos ». Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/7383.
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
The present research aimed to investigate the acute toxicity of glyphosate (Nphosphomethyl-glycine), the active ingredient of Roundup®, as well as of aminomethylphosphonic acid (AMPA), its main degradation product, in the teleost fish Poecilia reticulata, commonly known as guppies. Thus, were performed tests Lethal Concentration mean (LC50) and behavioral, histopathology and proteomics analysis. Male and female P. reticulata presented median lethal concentration (LC50) at 96h the values of 68.78 and 70.87 mg/L for glyphosate and 180.00 and 164.32 mg/L for AMPA, respectively, characterizing them as practically non toxic compounds to guppies. However, the results of behavioral analyses showed that both products generate stressing situations to the fish, causing behavioral changes such shock against the tank walls, hypoactivity, irregular swimming, swimming on the surface of water, darkening of the body, aggressiveness, and lethargy. Histopathological and morphometric analyses of liver and gill of guppies exposed to sublethal concentrations of glyphosate (35mg/L) and AMPA (82 mg/L) indicated that both organs were affected . The gills of fish exposed to the tested products presented higher reaction rates to progressive changes, such as proliferation of the interlamellar epithelium and partial and total fusion of secondary lamellae. Liver presented higher reaction rates to regressive changes, such as steatosis, pyknotic nuclei, and necrosis. The proteomic analysis showed that Glyphosate induces differential liver proteins in P. reticulata. The image analysis allowed measuring 225 spots in the control group and 180 spots in the group exposed to Glyphosate. Of this total, 88 spots were exclusive to the control group and 43 spots were exclusive of the treated group. Of the 137 spots matched between control and treated groups 13 were down regulated and 8 were up regulated due to sublethal exposure to Glyphosate. The behavioral, histopathological and proteomic changes observed indicated that, although considered to have low toxicity to animals in the guides that evaluate toxicity of chemicals, both glyphosate and AMPA promote that are deleterious to animal health, indicating the need to establish new parameters or modify concepts indicating the need to use several biomarkers, beyond assessing the mortality rate, to establish a more reliable criteria for toxicity parameters.
A presente pesquisa teve como objetivo investigar a toxicidade aguda do Glifosato (Nfosfometil-glicina), princípio ativo dos herbicidas Roundup, e do AMPA (ácido aminometil-fosfônico), seu principal produto de degradação. O sistema-modelo eleito para a investigação foi o teleósteo Poecilia reticulata. Realizaram-se testes de Concentração Letal média (CL50), análises comportamentais, histopatológicas e proteômicas. Os dados de mortalidade coletados durante o teste de Concentração Letal média (CL50) permitiram determinar os valores de 68,78 e 70,87 mg/L como CL50 do Glifosato e os valores de 180 e 164,32 mg/L como a CL50 do AMPA para machos e fêmeas de P. reticulata respectivamente. Tais valores caracterizam o Glifosato e o AMPA como praticamente não tóxico aos guarus em testes de toxicidade aguda. No entanto, os resultados das análises comportamentais também realizadas durante a CL50 mostraram que ambos os produtos testes são capazes de gerar situações de estresse aos peixes, causando alterações de comportamento como choques contra as paredes do aquário, hipoatividade, natação irregular, nado na superfície da água, escurecimento corporal, agressividade e letargia. As análises histopatológicas e morfométricas das brânquias e do fígado de guarus expostos a concentrações subletais de Glifosato (35µg/L) e de AMPA (82µg/L) indicaram que ambos os órgãos são alterados morfologicamente. As brânquias de peixes expostos aos produtos testes apresentaram maiores índices de reação para as alterações progressivas tais como aumento do epitélio interlamelar e fusão parcial e total das lamelas secundárias. O fígado por sua vez apresentou maiores índices de reação para as alterações regressivas como esteatose, núcleos picnóticos e necrose. As análises proteômicas mostraram que o Glifosato induz a expressão diferencial de proteínas hepáticas em P. reticulata. As análises das imagens dos géis permitiram mensurar 225 spots no grupo controle e 180 spots no grupo exposto a Glifosato. Desse total, 88 spots foram exclusivos do grupo controle e 43 spots foram exclusivos do grupo tratado. Dos 137 spots pareados entre os grupos controle e tratado 13 foram regulados negativamente e 8 foram regulados positivamente devido a exposição subletal ao Glifosato. As alterações encontradas indicam que o Glifosato e o AMPA, apesar de serem considerados poucos tóxicos por guias que avaliam a toxicidade de produtos químicos, são promotores de alterações deletérias para a saúde animal, indicando que há necessidade de estabelecimento de novos parâmetros ou mudança de conceitos, indicando a necessidade de utilizar vários biomarcadores, além da avaliação da taxa de mortalidade, para estabelecer um critério mais confiável para parâmetros de toxicidade.
Romano, Jocelyn Ann. « Acute Toxicity and Sub-Lethal Effects of Non-Point Source Pollutants on Invertebrates ». Diss., 2007. http://hdl.handle.net/10161/197.
Texte intégralLivres sur le sujet "Sub-acute toxicity"
Brown, V. K. Acute and sub-acute toxicology. London : Edward Arnold, 1988.
Trouver le texte intégralBrown, Vernon K. Acute and sub-acute toxicology. London : E. Arnold, 1988.
Trouver le texte intégralBrown, Vernon K. Acute and Sub-acute Toxicology. Cambridge University Press, 1992.
Trouver le texte intégralChapitres de livres sur le sujet "Sub-acute toxicity"
Doe, P., C. A. Danquah, K. A. Ohemeng, S. Nutakor, B. Z. Braimah, A. Amaglo, M. Abdul-Fatah et al. « Acute and Sub-acute Toxicity Studies of Solvent Extracts of Crinum pedunculatum Bulbs R.Br ». Dans Sustainable Education and Development – Sustainable Industrialization and Innovation, 752–62. Cham : Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-25998-2_59.
Texte intégralGouva, Evangelia, Cosmas Nathanailides, Ioannis Paschos, Fotini Athanassopoulou et Ioannis S. Pappas. « Acute and Sub-Lethal Toxicity of Aluminum on Developing Zebrafish Embryos ». Dans Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions (2nd Edition), 617–22. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-51210-1_97.
Texte intégralDenny, Kevin H., et Christopher W. Stewart. « Acute, Sub-Acute, Sub-Chronic and Chronic General Toxicity Testing for Preclinical Drug Development ». Dans A Comprehensive Guide to Toxicology in Preclinical Drug Development, 87–105. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-387815-1.00005-8.
Texte intégralCoelho-de-souza, Andrelina N., Maria Valdenir A. P. Rocha, Keciany A. Oliveira, Yuri A. G. Vasconcelos, Edgleyson C. Santos, Kerly Shamyra Silva-alves, Lúcio Ricardo L. Diniz et al. « VOLATILE OIL OF CROTON ZEHNTNERI PER ORAL SUB-ACUTE TREATMENT OFFERS SMALL TOXICITY : PERSPECTIVE OF THERAPEUTIC USE ». Dans Produtos Naturais e Suas Aplicações : da comunidade para o laboratório, 219–33. Editora Científica Digital, 2021. http://dx.doi.org/10.37885/210203416.
Texte intégralStafstrom, Carl E., Li-Rong Shao et Thomas P. Sutula. « Antiseizure and Antiepileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose ». Dans Ketogenic Diet and Metabolic Therapies, sous la direction de Susan A. Masino, Detlev Boison, Dominic P. D’Agostino, Eric H. Kossoff et Jong M. Rho, 498–508. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197501207.003.0038.
Texte intégralGhani, Rohma, et Caoimhe Nic Fhogartaigh. « Skin and Soft Tissue Infections ». Dans Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0038.
Texte intégralActes de conférences sur le sujet "Sub-acute toxicity"
Rahimi, Atena, Farideh Feizi, Farangiz Soorani, Davoud Ghorbani, Mostafa Sheikhzadeh, Fatemeh Kolangi et Zahra Memariani. « Evaluation of the renal toxicity potential of sub-acute exposure to the aqueous extract of Alpinia officinarum Hance. rhizome in rats ». Dans GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736926.
Texte intégralBatra, Ankit. « Clinical comparison of toxicity pattern of two linear quadratic model-baesd fractionation schemes of high-dose-rate intracavitary brachytherapy for cervical cancer ». Dans 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685255.
Texte intégral