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1
Galli de' Paratesi, Nora. « Il giudeo-italiano e i problemi della sua definizione : un capitolo di storia della linguistica ». Linguistica 32, no 2 (1 décembre 1992) : 107–32. http://dx.doi.org/10.4312/linguistica.32.2.107-132.
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Lo scopo di questo articolo è di portare all'attenzione dei linguisti che lavorano sull'italiano un argomento poco noto perché è stato trattato per lo più, per le caratteri stiche del suo materiale, al di fuori dell'italianistica: il cosiddetto giudeo-italiano. II termine si riferisce alle varieta dialettali usate in ima serie di documenti che sono stati oggetto di studio, con poche eccezioni, da parte di specialisti di ebraico. I testi hanno, aldilà del loro immediato valore come documenti della cultura ebraica italiana, anche un interesse linguistico: è questa appunto l'angolatura di questo lavoro, perché il ten tativo di definire tali parlate all'intemo delle varietà di italiano ha avuto varie soluzio ni da parte di studiosi diversi, che costituiscono un itinerario teorico molto interessante. Si tratta di uno spezzone di storia della linguistica italiana e romanza in cui si ripercorre un itinerario simile a quello della de:finizione di italiano standard. Si tratta di un percorso che è parallelo all'evoluzione della linguistica stessa e che è stato fino a non molto tempo fa, come si cercherà di dimostrare, dominato in larga parte dalla visione delle varietà linguistiche come sistemi discreti, unitari ed omogenei, propria della descrizione linguistica fino alla messa a punto dei modelli macrosocio linguistici che hanno incorporato sistematicamente la variazione e ii continuo lingui stico. In particolare nel nostro caso l'immagine del giudeo-italiano risentiva della concezione di un'entità quanto mai elusiva, che ha dominato la linguistica italiana, quella dell'italiano standard.
2
Barahona Plaza, Ángel Jorge. « Il leone che si è fatto agnello ». Xiphias Gladius Revista interdisciplinar de Teoría Mimética, no 3 (30 septembre 2020) : 149–53. http://dx.doi.org/10.32466/eufv-xg.2020.3.640.149-153.
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Collotti, Enzo. « L'Archivio di Ringelblum : una storia per il futuro ». ITALIA CONTEMPORANEA, no 262 (octobre 2011) : 51–63. http://dx.doi.org/10.3280/ic2011-262003.
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L'autore, sulla scorta del volume di Samuel D. Kassow (), affronta criticamente sia la biografia politico-intellettuale di Emmanuel Ringelblum - eminente storico dell'ebraismo polacco e principale cronista della distruzione del ghetto di Varsavia - sia la sua opera di costruzione dell'Archivio segreto del ghetto. Distaccatosi dalla storiografia tradizionale ebraica per riconoscersi nei principi e nel metodo del materialismo storico, Ringelblum aveva messo a punto un metodo di elaborazione della storia ebraica fondato non piů sui testi religiosi ma sulla raccolta piů ampia possibile di documenti e di testimonianze della vita quotidiana. Coniugando al mestiere di storico una provata attitudine di organizzatore, egli si servě del canale dell'Aleynhilf, importante societŕ di mutuo soccorso attiva nel ghetto di Varsavia, per creare l'Archivio. Allo scopo reclutň un nucleo di collaboratori altamente qualificati per raccogliere non semplici testimonianze ma veri e propri studi monografici legati all'esperienza del ghetto, e costituire cosě un corpo di opere destinate a creare i fondamenti culturali di una nuova piattaforma dell'ebraismo polacco. Presto perň il gruppo ebbe invece la percezione di essere sul punto di scrivere l'ultimo capitolo della storia degli ebrei polacchi: attuň cosě il primo interramento di parte del materiale dell'Archivio nell'agosto 1942, seguito da un altro nel febbraio 1943. Si ha notizia di un terzo interramento di cui perň non fu mai trovata traccia.
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Zappia, Andrea. « Inserire una minoranza nello spazio cittadino. Il caso della comunità ebraica di Genova (1658-1737) ». STORIA URBANA, no 167 (mai 2021) : 119–45. http://dx.doi.org/10.3280/su2020-167007.
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Il presente studio si propone di ripercorrere le vicende relative alla comunita ebraica genovese, specie nel suo rapporto con gli spazi cittadini, negli anni compresi tra i primi Capitoli della nazione ebrea concessi nel 1658 e l'ultima espulsione dalla citta, decretata nel 1737 e concretizzatasi sei anni dopo. Conseguentemente all'arrivo a Genova di un certo numero di ebrei, nell'agenda politica del patriziato si impose la questione del ghetto, che richiedeva lo studio di soluzioni di natura urbanistica ma che d'altra parte presentava ricadute sociali, economiche e culturali da valutare con grande attenzione. Lo smantellamento dei cancelli del ghetto avvenuto nel 1679, e la collocazione degli ebrei nel tessuto urbano, rendeva necessario ripensare la convivenza tra la popolazione autoctona e questa minoranza. Il mancato raggiungimento dell'equilibrio, le difficolta legate all'individuazione di una nuova area per l'erezione di un nuovo ghetto, oltre al definitivo tramonto dell'idea di riattivare un imponente traffico commerciale con il Levante, furono i motivi che causarono nel 1737 la revoca dei Capitoli e la conseguente cacciata degli ebrei dalla citta.
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Bragazzi, Nicola Luigi, et Cristina Tornali. « La medicina del rinascimento e la scoperta della circolazione minore ». Acta medico-historica Adriatica 15, no 2 (2017) : 271–82. http://dx.doi.org/10.31952/amha.15.2.5.
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Michele Serveto (1511-1533) è stato un umanista, medico e teologo. Si dedicò allo studio della Bibbia e si interessò anche alle scienze, astrologia, meteorologia, filosofia scolastica, geografia, legge, anatomia e matematica. Michele Serveto sviluppò una solida conoscenza delle lingue classiche (latino, greco ed ebraico) che egli utilizzerà molto per i suoi studi. Dopo i primi studi in casa e poi nella scuola del convento di Monte-Aragón, nel 1524 Serveto prestò servizio per due anni presso Juan de Quintana di Majorca, dottore alla Sorbona di Parigi, francescano minorita e importante membro delle Cortes di Aragona. Inizialmente sembrava essere destinato al sacerdozio ma poi, all’età di diciassette anni, nel 1528, Serveto fu mandato dal padre a studiare legge all’università di Tolosa, prestigiosa università per gli studi di giurisprudenza, ma dopo appena un anno abbandonò richiamato nel 1529 da Quintana, diventato nel frattempo confessore personale dell’imperatore Carlo V. È stato tardivamente riconosciuto come il primo medico – almeno in Europa – ad aver descritto la circolazione polmonare o circolazione minore. Per le sue posizioni contro la Trinità, è stato arrestato, processato e mandato al rogo a Champel, nel sobborgo ginevrino. Serveto rappresenta un profondo innovatore, sia nell’ambito della teologia che della medicina, un martire e un gigante del libero pensiero.
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Ebrahimi, Ehsan, et Dominique Unruh. « Quantum collision-resistance of non-uniformly distributed functions : upper and lower bounds ». Quantum Information and Computation 18, no 15&16 (décembre 2018) : 1332–49. http://dx.doi.org/10.26421/qic18.15-16-4.
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We study the quantum query complexity of finding a collision for a function f whose outputs are chosen according to a non-uniform distribution D. We derive some upper bounds and lower bounds depending on the min-entropy and the collision-entropy of D. In particular, we improve the previous lower bound by Ebrahimi Targhi et al. from \Omega(2^{k/9}) to \Omega(2^{k/5}) where k is the min-entropy of D.
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Rajak, Tessa. « Marina Pucci : La rivolta ebraica al tempo di Traiano. (Biblioteca di Studi Antichi, 33.) Pp. 158. Pisa : Giardini Editori e Stampatori, 1981. » Classical Review 35, no 1 (avril 1985) : 204–5. http://dx.doi.org/10.1017/s0009840x00108273.
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Forte, Bruno. « Considerazioni teologiche intorno all'ingegneria genetica ». Medicina e Morale 41, no 6 (31 décembre 1992) : 1063–73. http://dx.doi.org/10.4081/mem.1992.1081.
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Lo studio, prendendo le mosse dalla considerazione che l'ingegneria genetica tocca la relazione tra uomo, natura e cosmo, nonché quella tra l'uomo ed i suoi simili, prende atto della diversità di ritmi che i tempi biologici hanno rispetto a quelli storici per via delle rilevanti possibilità che l'uomo ha di intervenire sulla realtà. L'ingegneria genetica è, così, inquadrata nella più generale "crisi ecologica", dalle profonde radici filosofiche che sono tratteggiate dall'Autore. Vengono poi valutate criticamente le accuse che la filosofia ha mosso alla tradizione ebraico-cristiana riguardo al rapporto uomo-natura. Lo studio evidenzia ed analizza, infine, come tale tradizione si fondi non sull'autonomia bensì sull'eteronomia dell'uomo, ovvero sulla relazione tra l'essere umano e il Creatore nella solidarietà con tutto il creato, visto nella sua "interiorità". Alla luce di tali premesse saranno eticamente accettabili quegli interventi di ingegneria genetica che riconoscono come premessa l'eteronomia fondatrice prima citata, cioè il rispetto della centralità ed il valore assoluto della persona umana, in una dinamica di etica della solidarietà e della responsabilità.
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Hilhorst, A. « Marina PUCCI, La rivolta ebraica al tempo di Traiano (Biblioteca di studi antichi 33), Giardini Editori e Stampatori, Pisa 1981, 165 pp., paper, n.pr ». Journal for the Study of Judaism 16, no 1 (1985) : 151–52. http://dx.doi.org/10.1163/157006385x00249.
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Bajri, Ibtesam AbdulAziz. « A Sociolinguistic Study of Cultural Effects on Speech Acts in the South and West of Saudi Arabia’s Community ». Advances in Social Science and Culture 4, no 3 (23 juin 2022) : p1. http://dx.doi.org/10.22158/assc.v4n3p1.
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The purpose of this research is to examine the speech act of welcoming unexpected guests in the Hijaz and Al-Janoub communities in Saudi Arabia. Discourse Completion Task (DCT) is adopted to gather the required data, where all the questions are open-ended questions. The study investigates how gender of the host/guest affects the welcoming speech act of an unexpected guest and what the strategies contribute to welcoming an unexpected guest in Hijaz and Al-Janoub areas. It also focuses on the significant impact of religious values among Saudis. Selected coding schemes of Ebrahimi, Pirbabaei and Mehrabad (2015), Al-Zubaidi (2012), Setin (2018), and Allami (2012) are utilized for the data analysis of this study. The results show that both of the above communities, whether males or females, accept unexpected guests. It has been revealed that language, gender, and religion have a great impact on the results of this study. The majority of the female participants opt out of communicative patterns that show rejection to welcoming strange or relative male in some situations where they are visited by a strange male or relative from the opposite sex while they are alone at home.
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Rubin, Aaron D. « Storia della lingua ebraica. By Ángel Sáenz Badillos. Introduzione allo studio della Bibbia, Supplementi 34. Translated by, Piero Capelli. Brescia : Paideia Editrice, 2007. Pp. 378. » Journal of Near Eastern Studies 70, no 2 (octobre 2011) : 319–20. http://dx.doi.org/10.1086/661058.
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Porntadawit, Jiranuwat, Vitoon Uthaisangsuk et Paiboon Choungthong. « Modeling of Flow Curve at High Temperature for a Ti-6Al-4V Alloy ». Advanced Materials Research 849 (novembre 2013) : 195–99. http://dx.doi.org/10.4028/www.scientific.net/amr.849.195.
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Titanium alloy grade Ti-6Al-4V has been widely applied for many applications such as aircraft structural components, machine parts, and parts for medical equipments. To understand deformation behavior and microstructure evolution of the material during hot forming process is significant for achieving desired dimension and final mechanical properties of a product. In this study, stress-strain responses of the Ti-6Al-4V alloy were investigated using hot compression tests at different temperatures and strain rates. The determined flow curves of the alloy were subsequently calculated according to the constitutive models based on Cingara equation and Shafiei and Ebrahimi equation and compared with the experimental results. By this manner, influences of work hardening and dynamic recrystallization on the hot deformation behavior of material could be described. Accurate prediction of flow curves can considerably improve the forming process design.
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Maier, Johann. « Bruno Ognibeni, Tradizioni orali di lettura e testo ebraico de/la Bibbia. Studio dei diciasette Ketiv l’I Qere Iô. Fribourg (Éditions universitaires Fribourg Suisse), 1989, xvii & ; 274 S. (Studia Friburgensia. Nouvelle série 72). » Biblische Zeitschrift 36, no 1 (22 septembre 1992) : 125–27. http://dx.doi.org/10.1163/25890468-03601019.
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Fabi, Alessandra, Irene Terrenato, Antonello Vidiri, Veronica Villani, Antonio Tanzilli, Mario Airoldi, Fulvia Pedani et al. « Eribulin in brain metastases of breast cancer : outcomes of the EBRAIM prospective observational trial ». Future Oncology 17, no 26 (septembre 2021) : 3445–56. http://dx.doi.org/10.2217/fon-2021-0300.
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Background: Eribulin shows some activity in controlling brain metastasis in breast cancer. Methods: This observational, multicenter study evaluated brain disease control rates, survival and safety in patients with brain metastatic breast cancer treated with eribulin in clinical practice. Results: A total of 34 patients were enrolled (mean age 49 years, 91% with visceral metastases) and 29 were evaluable for brain disease. Fourteen achieved disease control and showed a longer time without progression: 10 months (95% CI: 2.3–17.7) versus 4 months (95% CI: 3.3–4.7) in the control group (p = 0.029). Patients with clinical benefits at 6 months had longer survival. Leukopenia and neutropenia were the most frequent grade 3–4 toxicities. Conclusion: Eribulin confirms its effectiveness in patients with brain metastatic breast cancer. Further studies on larger cohorts are needed to confirm the results.
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Yoo, J. D., M. C. Kim, E. J. Kim, M. K. Razali et M. S. Joun. « Flow stress characterization of magnesium alloys at elevated temperatures : A review ». Journal of Physics : Conference Series 2047, no 1 (1 octobre 2021) : 012002. http://dx.doi.org/10.1088/1742-6596/2047/1/012002.
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Abstract The flow behaviors of magnesium alloys are too complicated to be simply formulated in a mathematical form. Most researches have based metallurgically or phenomenologically on specific functions with many constants, which could be applied only to the limited magnesium alloys under specific conditions. In this study, a review on the studies of flow stress characterization of magnesium alloys is conducted and the possibility of using the traditional piecewise C-m model and its extension to characterize the magnesium alloys is emphasized. The formulations of major flow models are given with three typical applications to magnesium alloy AZ80 and its characteristics are demonstrated through comparison of the fitted flow behaviors with their associated experiments and various flow stress models including Arrehenius model, four Ludwik family models (Johnson Cook, Modified Johnson-Cook, Hensel-Spittel, Sutton-Luo), two Voce family models (Ebrahimi et al., Razali et al.) and C-m models.
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Ebrahimi, Seyed Foad. « “THE OVERALL AIM OF THIS WORK IS ….” FUNCTIONAL ANALYSIS OF GRAMMATICAL SUBJECT IN RESEARCH ARTICLE INTRODUCTIONS ACROSS FOUR DISCIPLINES ». Discourse and Interaction 10, no 1 (16 janvier 2017) : 5–30. http://dx.doi.org/10.5817/di2017-1-5.
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This study investigates the types and discourse functions of grammatical subjects inresearch article introductions across four disciplines, namely: Applied Linguistics andPsychology, representing soft sciences, and Chemistry and Environmental Engineering,representing hard sciences. This study was carried out on a corpus of 40 research articleintroductions (10 from each discipline). The research article introductions were sourcedfrom twelve ISI journals published from 2008 to 2012. The corpus was analysed basedon the modified model in relation to grammatical subject types and discourse functionssuggested by Ebrahimi (2014). The results revealed that the grammatical subject typeselections were guided by the nature of the research article introduction. However, thefrequency of use of the grammatical subject types was constrained by the nature ofthe discipline. Discourse functions of grammatical subject types were predominantlydetermined by the divisions of the hard and soft sciences, and the specific disciplineswithin and the internal structure of the research article introductions. In addition, theresults of this study manifest a new framework for the analysis of discourse functions ofgrammatical subject types in research article introductions.
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Azizi, Ali, et Sadollah Ebrahimi. « Uniaxial-Strain Effects in the Paclitaxel Drug Molecule Adsorption on Nitrogen-Doped Graphene ». International Journal of Nanoscience 16, no 02 (15 août 2016) : 1650027. http://dx.doi.org/10.1142/s0219581x16500277.
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It has been recently investigated [A. Azizi and S. Ebrahimi, Nano 9, 1450088 (2004).] the Paclitaxel (PTX) anticancer drug molecule adsorption on nitrogen doped graphene (NG). However, the surface strain effect on adsorption is not considered in the literature. In this study, using molecular dynamics (MD) simulation, we show that the PTX molecule adsorption can be tuned by exploiting the rippling effect of the strained NG. The dependence of the nitrogen concentration in the presence of ripples on the surface, arising due to thermal fluctuations, is examined. We have also considered the connection between the average distance of PTX from NG surface and the maximum induced deformation on the surface structure. It is demonstrated that the average distance of PTX from NG is increased with increasing the strain until a critical value is reached, and then it has remained almost constant. To this end, the dependence of the degree of ripple-type distortion of the surface on the PTX adsorption is investigated.
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Shahbaz, Leila. « C-DENSE INJECTIVITY IN Act-S ». Asian-European Journal of Mathematics 05, no 01 (mars 2012) : 1250010. http://dx.doi.org/10.1142/s1793557112500106.
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To study mathematical notions, such as injectivity with respect to the class [Formula: see text] of (mono)morphisms in a category [Formula: see text], one needs to have some categorical and algebraic information about the pair ([Formula: see text], [Formula: see text]). In this paper, we take [Formula: see text] to be the category Act-S of acts over a semigroup S, C to be an arbitrary closure operator in the category Act-S, and [Formula: see text] to be the class of C-dense monomorphisms resulting from a closure operator C and first study some categorical properties of the pair (Act-S, [Formula: see text]). Then injectivity with respect to the class of C-dense monomorphisms is studied. The class of sequentially dense monomorphisms resulting from a special closure operator (sequential closure operator) and injectivity with respect to this class of monomorphisms have been studied by Giuli, Ebrahimi, Mahmoudi and the author. Some of these results generalize some of the results about the class of sequentially dense monomorphisms.
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Alif, Alfian, Annisa Kesy Garside, Ikhlasul Amallynda et Baiq Nurul Izzah Farida Ramadhani. « Solving Capacitated Vehicle Routing Problem Using Football Game Algorithm ». Jurnal Ilmiah Teknik Industri 21, no 1 (30 juin 2022) : 27–36. http://dx.doi.org/10.23917/jiti.v21i1.15812.
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The Capacitated Vehicle Routing Problem (CVRP) plays an important role in the logistics transportation sector. Determining the proper route will reduce the company's operational costs. In CVRP, a number of vehicles have a capacity limit that can serve all customers. This research completes a real case study on a bottled drinking water company where the company still uses the subjective method of the driver to determine the transportation route. Based on the conditions in the company, the selection of the best route will consider vehicle capacity and demand to determine the shortest route. The execution of this case study uses the Football Game Algorithm (FGA) which was first initiated by Fadakar Ebrahimi which proved promising and had the strongest performance in all cases. FGA is expected to be able to determine the shortest distribution route from the existing cases to reduce the distribution costs incurred. This study takes data from 4 days of delivery that served 78 customers. The average daily transportation cost savings result is 42%. This amount indicates that the FGA algorithm is effective for completing a real case study in CVRP.
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Ebrahimi, M. M., et M. Mahmoudi. « CATEGORY OF M-ALGEBRAS AND INTERNAL HOMOMORPHISMS ». Asian-European Journal of Mathematics 03, no 02 (juin 2010) : 307–22. http://dx.doi.org/10.1142/s1793557110000210.
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Recall that for (universal) algebras A and B in a category [Formula: see text], [Formula: see text] is usually an external object, in the sense that it is just a set and is neither an algebra nor an (internal) object of the base category [Formula: see text]. Ebrahimi introduced an object [A, B] inside [Formula: see text] to be the best counterpart of Hom(A, B), for universal algebras A, B in a Grothendieck topos [Formula: see text]. In this paper, taking a monoid M and an equational category of algebras [Formula: see text], we introduce the category [Formula: see text] of universal algebras in the category [Formula: see text], of sets with an action of a monoid M, together with members of [A, B], called internal homomorphisms, as the M-set of homomorphisms from A to B. We study some algebraic and categoric ingredients, monomorphisms, epimorphisms, limits and colimits, of the category [Formula: see text]. Among other things, we show that in this category equalizers do not exist in general while all colimits exist.
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Aron-Beller, Katherine. « “Interstizi” : Culture ebraico-cristiane a Venezia e nei suoi domini dal medioevo all’età moderna. Edited by Uwe Israel, Robert Jütte, and Reinhold C. Mueller. Ricerche / Centro tedesco di studi veneziani, vol. 5. » Jewish History 27, no 1 (mars 2013) : 113–18. http://dx.doi.org/10.1007/s10835-012-9171-5.
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Haron, Hasnah, Nurul Nazlia Jamil et Nathasa Mazna Ramli. « WESTERN AND ISLAMIC VALUES AND ETHICS : ARE THEY DIFFERENT ? » Journal of Governance and Integrity 4, no 1 (27 novembre 2020) : 12–28. http://dx.doi.org/10.15282/jgi.4.1.2020.5609.
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Values are fundamental paradigms that shape attitudes and guide behaviour of human. Values shape morals, where morals help in shaping ethics. The first objective of this paper is to reviews values and ethics based on western and Islamic perspectives. The second objective specifically compares western and Islamic values. For comparison purposes, western values are represented by Schwartz values, while Islamic values are based on a study from Ghoniyah and Hartono (2014) and Ebrahimi and Yusoff (2017). Quran and Sunnah were referred to in highlighting the difference between the western and Islamic values. The analysis is done based on four dimensions, namely self-enhancement, openness to change, self-transcendence and conservation. The study finds that there are a lot of similarities between western and Islamic values. Both values have the same intention of nurturing better mankind. However, there are two western values, namely “Power” and “Hedonism” that has no direct link with Islamic values. This is because, in Islam, Muslims believe that only Allah SWT has the ultimate will and power over life and death. Besides that, Islam encourages the attitude of promoting mashlahah rather than focusing on worldly pleasures. This paper adds to the literature and provides a comparison of values that would be beneficial to organizations and academic institutions in instilling values in their own setting
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BRÎNZEI, MONICA. « PRINCIPIA ON THE SENTENCES IN THE FACULTY OF THEOLOGY OF BOLOGNA : THE CASE OF AUGUSTINUS FAVARONI OF ROME, OESA (†1443) ». Traditio 77 (2022) : 377–463. http://dx.doi.org/10.1017/tdo.2022.4.
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The Faculty of Theology of Bologna, founded in 1364, presents a paradox when we investigate its custom of performing principia on the Sentences prior to 1400. Although we are fortunate to have from Bologna the most complete surviving documentation concerning the organization of a medieval theology faculty, only two complete sets of principia have been identified so far from the matricula of 450 known scholastics. The situation hinders any comparative investigation that intends to test how what is depicted in the statutes is reflected in practice. The two surviving sets of principia from Bologna are those of the Cistercian Conrad of Ebrach, from 1368–1369, and the Augustinian Augustinus Favaroni of Rome, dating to 1388–1389. This study uses Augustinus Favaroni's principia to illustrate how this academic exercise functioned at the University of Bologna. It begins with a biographical sketch of Augustinus Favaroni of Rome followed by a short description of the principia as mirrored in the statutes of Bologna. It continues with a brief summary of each of the four principia of Favaroni reporting the philosophical and theological topics developed in his text, with an emphasis on the debates in which he engaged to defend his theses, and concludes with an appendix containing an edition of the four principia.
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Hamidi, Hamid, Azad Khosh, Hamzeh Rahimi et Diako Ebrahimi. « Abstract P5-13-05 : Profiling of APOBEC3 dysregulation in breast cancer ». Cancer Research 83, no 5_Supplement (1 mars 2023) : P5–13–05—P5–13–05. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-13-05.
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Abstract DNA of many breast tumors is barraged by C-to-T/G mutations within TCW (W:T,A). These mutations are attributed to the aberrant expression and activity of APOBEC3 enzymes. They have been shown to account for many driver mutations in genes such as PIK3CA, ERBB2, and PPP2R1A, however their precise source and also their roles in tumor development, evolution, and patient survival are debated. Currently, quantification of APOBEC3 expression changes in tumor cells is confounded by the ubiquitous expression of these enzymes in immune infiltrating cells. In this study, we used a novel quantitative biology approach to determine the expression profiles of APOBEC3 enzymes in breast tumor and tumor microenvironment cells from >1,000 patients. We combined diverse datasets including tumor/matched normal RNAseqs, tumor somatic mutations, cell line RNAseqs and mutations, estimates of tumor purities and immune cell compositions, and expression of purified cell populations to show that in breast cancer there is only a single APOBEC3 dysregulation process. This process is subtype-independent and is represented by APOBEC3B upregulation and and extreme APOBEC3C downregulation. Compared to all other tumor types, breast tumors are affected the most by this process. Citation Format: Hamid Hamidi, Azad Khosh, Hamzeh Rahimi, Diako Ebrahimi. Profiling of APOBEC3 dysregulation in breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-13-05.
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Abdollahi, Mojtaba, Masoumeh Ebrahimi, Alireza Sarraf Shirazi et Faraneh Abdolhoseinpour. « Effect of Tannic Acid on Bond Strength of Etch and Rinse and Self-etch Adhesive Systems in Dentin of Primary Teeth ». Journal of Contemporary Dental Practice 18, no 1 (janvier 2017) : 34–38. http://dx.doi.org/10.5005/jp-journals-10024-1984.
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ABSTRACT Introduction One of the possible mechanisms for the gradual destruction of bond strength in dentin-resin interface, could be due to the demineralized unstable collagen matrix. Use of protease inhibitors, such as tannic acid (TA) could prevent destruction of collagen fibers. The aim of this study was to compare the TA effect on bond strength of etch and rinse and self-etch adhesive systems in the dentin of primary teeth. Materials and methods This in vitro study was done on 40 extracted primary molar teeth. The teeth were sectioned in the mesiodistal direction, and enamel of buccal and lingual surfaces was removed. Samples were randomly divided into four groups: Single bond (SB) + TA, SB, Clearfil SE Bond (CSB) + TA, and CSB. Then, Z250 and Clearfil AP-X composites were cured on the surfaces of SB and CSB groups respectively. After that, all samples were divided into aging and non-aging groups. For 3 months, samples were placed under 1,000 thermal cycles in aging group. Subsequently, the shear bond strengths of all groups were measured by the International testing machine, and failure mode was evaluated by an optical stereomicroscope. Data were analyzed with paired t-test and independent t-test. Results Tannic acid induced a significant reduction in the immediate bond strength of adhesive SB. Meanwhile, TA had no significant effect on shear bond strength of the CSB system. Conclusion Based on our findings, use of TA is not recommended with SB and CSB adhesives on primary teeth. Clinical significance Tannic acid may not be considered in resin restorations of primary teeth. How to cite this article Ebrahimi M, Sarraf Shirazi A, Abdolhoseinpour F, Abdollahi M. Effect of Tannic Acid on Bond Strength of Etch and Rinse and Self-etch Adhesive Systems in Dentin of Primary Teeth. J Contemp Dent Pract 2017;18(1):34-38.
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Furstenberg-Levi, Shulamit. « Uwe Israel, Robert Jütte, and Reinhold C. Mueller, eds. “Interstizi” : Culture ebraico-cristiane a Venezia e nei suoi domini dal medioevo all’età moderna. Centro Tedesco di Studi Veneziani 5. Rome : Edizioni di Storia e Letteratura, 2010. 600 pp. + 1 color pl. index. append. illus. tbls. map. €74. ISBN : 978–88–6372–154–6. » Renaissance Quarterly 64, no 3 (2011) : 974–76. http://dx.doi.org/10.1086/662914.
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Cussini, E. « FRANCESCO ASPESI, VERMONDO BRUGNATELLI, ANNA LINDA CALLOW and CLAUDIA ROSENZWEIG (eds), Il mio cuore e a Oriente, Studi di linguistica storica, filologia e cultura ebraica dedicati a Maria Luisa Mayer Modena * CLAUDIA ROSENZWEIG, ANNA LINDA CALLOW, VERMONDO BRUGNATELLI and FRANCESCO ASPESI (eds), Florilegio Filologico Linguistico. Haninura de Bon Siman a Maria Luisa Mayer Modena ». Journal of Semitic Studies 56, no 1 (1 mars 2011) : 183–85. http://dx.doi.org/10.1093/jss/fgq064.
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Daar, Eric, Jason Brunetta, Eric Cua, Jason Flamm, David Asmuth, Christoph C. Carter, Yongwu Shao et al. « 985. Impact of Age and Medical Comorbidities on Renal Outcomes in the DISCOVER Trial ». Open Forum Infectious Diseases 7, Supplement_1 (1 octobre 2020) : S521. http://dx.doi.org/10.1093/ofid/ofaa439.1171.
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Abstract Background In DISCOVER, emtricitabine/tenofovir alafenamide (F/TAF) was noninferior to F/tenofovir disoproxil fumarate (TDF) for preexposure prophylaxis (PrEP) in men who have sex with men and transgender women, with a superior renal laboratory profile. The differential impact of F/TAF and F/TDF on renal parameters among older individuals and those with medical comorbidities is unknown. Methods DISCOVER randomized participants 1:1 to daily blinded F/TAF or F/TDF. We examined renal outcomes at week 48 including estimated glomerular filtration rate (eGFR) by Cockcroft-Gault, β2 microglobulin (M):Creatinine (Cr) and retinol binding protein (RBP):Cr ratios (markers of proximal renal tubular function), and discontinuations due to investigator reported study drug-related renal adverse events (AEs). Results Median age was 34 years (yrs)(range 18-76), with 12.5% vs 10.9% < 25yrs, 12.2% vs 14.4% ≥ 50yrs, and 1.1% vs 0.9% > 65yrs for F/TAF and F/TDF, respectively. The prevalence of medical comorbidities at baseline were; eGFR < 90mL/min= 9.1% vs 9.3%, diabetes= 2.9% vs 3.3%, and hypertension= 10.5 vs 11.1%, for F/TAF and F/TDF, respectively. eGFR changes by age category and medical comorbidity status are found in the Table. Forty participants had study drug-related renal AEs; 14 with F/TAF and 26 with F/TDF. Of these, 25% were > 50yrs, 20% had baseline eGFR < 90mL/min, 7.5% had history of diabetes, and 22.5% had history of hypertension. β2M:Cr and RBP:Cr changes were more favorable in participants receiving F/TAF, with greater magnitude of difference in older participants (data not shown). Table. Conclusion The DISCOVER trial allows for a large single variable comparison of the two tenofovir prodrugs in the absence of underlying HIV infection and in the absence of third antiretroviral agents. F/TAF was associated with favorable changes in renal biomarkers regardless of age or medical comorbidity. Participants ≥50yrs or with comorbidities were proportionately more likely to develop study drug related renal AEs, but these were present in the minority of cases. Disclosures Eric Daar, MD, BMS (Consultant)Gilead Sciences Inc. (Consultant, Grant/Research Support, Scientific Research Study Investigator)Janssen (Consultant)Merck (Consultant, Grant/Research Support)Teva (Consultant)Theratechnology (Consultant)Viiv Healthcare (Consultant, Grant/Research Support) Jason Brunetta, MD, AbbVie (Consultant)Gilead Sciences Inc. (Consultant, Grant/Research Support, Scientific Research Study Investigator, Speaker’s Bureau, Other Financial or Material Support, Conference attendance sponsorship)Janssen (Other Financial or Material Support, Conference attendance sponsorship)Merck (Consultant, Speaker’s Bureau, Other Financial or Material Support, Conference attendance sponsorship)Viiv Healthcare (Consultant, Speaker’s Bureau, Other Financial or Material Support, Conference attendance sponsorship) Eric Cua, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) David Asmuth, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Christoph C. Carter, MD, Gilead Sciences Inc. (Employee, Shareholder) Yongwu Shao, PhD, Gilead Sciences Inc. (Employee, Shareholder) Pamela Wong, MPH, Gilead Sciences Inc. (Employee, Shareholder) Ramin Ebrahimi, MSc, Gilead Sciences Inc. (Employee, Shareholder) Moupali Das, MD, Gilead Sciences Inc. (Employee, Shareholder) Diana M. Brainard, MD, Gilead Sciences (Employee) Amanda Clarke, MD, Gilead Sciences Inc. (Consultant, Scientific Research Study Investigator, Other Financial or Material Support, Conference attendance sponsorship)Viiv Healthcare (Consultant, Other Financial or Material Support, Conference travel sponsorship)
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Viswanadhapalli, Suryavathi, Uday P. Pratap, Behnam Ebrahimi, Logan Blankenship, Jaitri Joshi, Zexuan Liu, Kristin A. Altwegg et al. « Abstract P5-10-01 : Leukemia inhibitory factor receptor inhibition reduces obesity driven progression of triple negative breast cancer ». Cancer Research 82, no 4_Supplement (15 février 2022) : P5–10–01—P5–10–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-10-01.
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Abstract Background: The obesity epidemic is rapidly increasing in the USA and obese women are at a higher likelihood of developing triple negative breast cancer (TNBC). Several studies implicated the importance of the breast microenvironment on the aggressive cancer biology especially obese microenvironment. However, the underlying mechanism(s) by which obesity contributes to the progression of TNBC remains unclear. The objective of this study is to test a novel concept that obesity upregulates leukemia inhibitory factor receptor (LIFR) oncogenic signaling in TNBC and test whether LIFR inhibition blocks TNBC progression. Methods: Established TNBC cell lines were co-cultured with human primary adipocytes or incubated with adipocyte conditioned medium or with high glucose (HG) followed by treatment with LIFR inhibitor EC359. The effect of adiposity on TNBC cells was determined using cell viability, colony formation, and invasion assays. Mechanistic studies were performed using CRISPR/Cas9 KO of LIFR, Western blotting, RT-qPCR, and reporter gene assays. Utility of LIFR inhibitor EC359 was tested using xenografts, and patient derived organoid (PDO) models. Results: Treatment of TNBC cells with adipose conditions or HG increased the proliferation and invasion of TNBC cells. Western blot and RT-qPCR analyses confirmed that increased expression of LIFR correlated with enhanced downstream LIFR signaling such as STAT3 and subsequent activation of STAT3 target genes. CRISPR KO of LIFR or treatment of TNBC cells with EC359 significantly reduced the cell viability, colony formation and invasion under adipose conditions. Western blotting results showed that co-culture with adipocytes significantly enhanced LIFR downstream signaling in TNBC model cells and is effectively blocked by LIFR KO or EC359 treatment. Further, EC359 treatment blocked the adipose environment mediated growth of organoids. Importantly, co-implantation of adipocytes significantly enhanced TNBC xenograft tumor growth, however treatment with EC359 significantly attenuated adipocyte induced TNBC progression. Conclusions: Collectively, these results suggest that adiposity contributes to increased TNBC cell growth via upregulation of the LIF/LIFR pathway. The LIF/LIFR axis represents a potential therapeutic target for adiposity driven TNBC and the LIFR inhibitor EC359 could be used as a new therapeutic agent to treat obesity associated TNBC. Citation Format: Suryavathi Viswanadhapalli, Uday P Pratap, Behnam Ebrahimi, Logan Blankenship, Jaitri Joshi, Zexuan Liu, Kristin A Altwegg, Xiaonan Li, Gangadhara R Sareddy, Bindu Santhamma, Swapna Konda, Manjeet Rao, Edward Kost, Rajeshwar R Tekmal, Hareesh B Nair, Ratna K Vadlamudi. Leukemia inhibitory factor receptor inhibition reduces obesity driven progression of triple negative breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-10-01.
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Ebrahimi-Nik, Hakimeh, Arvin Iracheta-Vellve, Kira E. Olander, Thomas R. G. Davis, Sarah Y. Kim, Mitchell D. Yeary, James C. Patti et al. « Abstract A41 : Small molecule inhibition of PTPN2/1 inflames the tumour microenvironment and unleashes potent CD8+ T cell immunity ». Cancer Immunology Research 10, no 12_Supplement (1 décembre 2022) : A41. http://dx.doi.org/10.1158/2326-6074.tumimm22-a41.
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Abstract Immune checkpoint blockade is effective for a subset of patients across many cancers, but most patients are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatase PTPN2 is a central regulator of inflammation, and genetic deletion of PTPN2 on either tumour cells or host immune cells promotes anti-tumour immunity. However, inhibitors of PTPN2 with suitable pharmacokinetic properties for oral administration have not been described. Here, we present the characterization of ABBV-CLS-484 (A484), a potent active site inhibitor of PTPN2 and the closely related phosphatase PTPN1. A484 treatment in vitro amplifies the response to interferon gamma, and monotherapy A484 treatment generates robust anti-tumour immunity in several murine cancer models. Through in vivo studies and single cell transcriptional profiling of tumour-infiltrating lymphocytes (TIL) from A484-treated mice, we show that A484 inflames the tumour microenvironment and promotes CD8+ T cell function by enhancing cytokine signaling and decreasing T cell exhaustion and dysfunction. Our results demonstrate that oral administration of small molecule inhibitors of PTPN2/N1 can induce potent anti-tumour immunity in mouse models. PTPN2/N1 inhibitors offer a promising new strategy for cancer immunotherapy and are currently being evaluated clinically in patients with advanced solid tumours (NCT04777994). More broadly, our study shows that small molecule inhibitors of key intracellular immune regulators can achieve efficacy comparable to current antibody-based immune checkpoint blockade in preclinical models. Finally, to our knowledge A484 represents the first active-site phosphatase inhibitor to enter clinical evaluation for cancer immunotherapy and may pave the way for additional therapeutics targeting this important class of enzymes. Citation Format: Hakimeh Ebrahimi-Nik, Arvin Iracheta-Vellve, Kira E. Olander, Thomas R.G. Davis, Sarah Y. Kim, Mitchell D. Yeary, James C. Patti, Tyler M. Balon, Omar Ismail Avila, Cun Lan Chuong, Meng-Ju Wu, Christina K. Baumgartner, Keith M. Hamel, Kathleen A. McGuire, Rebecca Mathew, Carey Backus, Ian C. Kohnle, Zhaoming Xiong, Elliot P. Farney, Jennifer M. Frost, Geoff T. Halvorsen, Matthew Rees, Andrew Boghossian, Melissa Ronan, Jennifer A. Roth, Todd R. Golub, Gabriel K. Griffin, Nabeel El-Bardeesy, Clay C. Beauregard, Philip R. Kym, Kathleen B. Yates, Robert T. Manguso. Small molecule inhibition of PTPN2/1 inflames the tumour microenvironment and unleashes potent CD8+ T cell immunity [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy; 2022 Oct 21-24; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(12 Suppl):Abstract nr A41.
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Campbell, Thomas, Amanda Clarke, Benoit Trottier, Christoph C. Carter, Yongwu Shao, Ramin Ebrahimi, Moupali Das, Diana M. Brainard et Jay Gladstein. « 995. Safety and Efficacy of F/TAF and F/TDF for PrEP in DISCOVER Participants Taking F/TDF for PrEP at Baseline ». Open Forum Infectious Diseases 7, Supplement_1 (1 octobre 2020) : S526—S527. http://dx.doi.org/10.1093/ofid/ofaa439.1181.
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Abstract Background DISCOVER is an ongoing trial comparing emtricitabine plus tenofovir alafenamide (F/TAF) or tenofovir disoproxil fumarate (F/TDF) for HIV pre-exposure prophylaxis (PrEP). DISCOVER included some participants already taking F/TDF for PrEP at baseline (BL) creating a unique opportunity to study outcomes after switching from F/TDF to F/TAF. Methods Men who have sex with men and transgender women at risk of HIV were randomized to receive blinded daily F/TAF or F/TDF and followed for at least 96 weeks; participants taking BL F/TDF for PrEP could enroll without a washout period. Laboratory assessments included estimated glomerular filtration rate (eGFR), markers of renal proximal tubular function (RBP and β2M to creatinine ratios), and fasting cholesterol levels; these were analyzed by 2-sided Wilcoxon rank sum test. Bone mineral density (BMD) was assessed in a subset of participants and analyzed by ANOVA. Results 905 of 5387 (16.8%) participants were on BL F/TDF for PrEP for a median duration of 399 days; baseline characteristics are found in Table 1. There was one HIV infection among BL PrEP users, in a participant randomized to F/TDF who had intermittent low adherence. Participants on BL PrEP randomized to F/TAF had improvements in eGFR and markers of proximal tubular function compared to F/TDF. Median change in BMD was not statistically different for BL PrEP users assigned to F/TAF vs F/TDF, however de novo F/TAF participants had improved BMD profiles compared to F/TDF. BL PrEP users in the F/TAF arm had increases in LDL cholesterol (median +6mg/dL) compared to F/TDF, while changes in HDL and total:HDL ratio were similar. Lipid-modifying agent (LMA) initiation in BL PrEP users was more frequent in the F/TAF arm, while LMA initiation in de novo PrEP participants was similar between arms (Table 2). Table 1. Characteristics of DISCOVER participants Table 2. Efficacy and safety results Conclusion HIV incidence was low in participants taking BL PrEP. Participants who switched from F/TDF to F/TAF had improvements in renal biomarkers. There was no statistical difference in BMD among BL PrEP users, although numbers were small. The observed lipid changes in BL PrEP users are consistent with the LDL and HDL suppressive effect of TDF, and the small but higher rate of LMA initiation with F/TAF is likely related to withdrawal of this effect. Disclosures Thomas Campbell, MD, Gilead Sciences Inc. (Scientific Research Study Investigator) Amanda Clarke, MD, Gilead Sciences Inc. (Consultant, Scientific Research Study Investigator, Other Financial or Material Support, Conference attendance sponsorship)Viiv Healthcare (Consultant, Other Financial or Material Support, Conference travel sponsorship) Benoit Trottier, MD, AbbVie (Grant/Research Support, Other Financial or Material Support, Personal fees)Bristol-Myers Squibb (Grant/Research Support, Other Financial or Material Support, Personal fees)Gilead Sciences Inc. (Grant/Research Support, Scientific Research Study Investigator, Other Financial or Material Support, Personal fees)Janssen (Grant/Research Support, Other Financial or Material Support, Personal fees)Merck (Grant/Research Support, Other Financial or Material Support, Personal fees)Viiv Healthcare (Grant/Research Support, Other Financial or Material Support, Personal fees) Christoph C. Carter, MD, Gilead Sciences Inc. (Employee, Shareholder) Yongwu Shao, PhD, Gilead Sciences Inc. (Employee, Shareholder) Ramin Ebrahimi, MSc, Gilead Sciences Inc. (Employee, Shareholder) Moupali Das, MD, Gilead Sciences Inc. (Employee, Shareholder) Diana M. Brainard, MD, Gilead Sciences (Employee) Jay Gladstein, MD, Gilead Sciences Inc. (Scientific Research Study Investigator)
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Mathias, K., L. Mathias, A. Mantha et D. Arkfeld. « POS0252 IMPACT OF ANCA-ASSOCIATED VASCULITIS ON CLINICAL OUTCOMES AND RESOURCE UTILIZATION IN ELECTIVE PCI ». Annals of the Rheumatic Diseases 80, Suppl 1 (19 mai 2021) : 348.2–348. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3369.
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Background:Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides (AV) can increase risk of atherosclerosis. 1 Patients with autoimmune disease have increased rates of coronary events that are not fully explained by classic risk factors. 2 A prior study has shown that autoimmune vasculitides –including polyarteritis nodosa, hypersensitivity granulomatosis with polyangiitis, giant cell arteritis, thrombotic angiitis, Takayasu arteritis, Goodpasture syndrome, and Kawasaki disease –are associated with increased cost of care and increased 30-day readmission after percutaneous coronary intervention (PCI). 3 It is important to distinguish the cardiovascular outcomes of small–vessel ANCA-associated vasculitides from the other vasculitides included in this prior study because coronary arteritis is typically a complication of medium to large vessel vasculitis.Objectives:To investigate the impact of comorbid ANCA-associated small vessel vasculitis (AV) on outcomes of PCI in a nationally representative cohort.Methods:Patients undergoing PCI in the 2016-2018 National Inpatient Sample were selected and those with ANCA-associated vasculitis were identified using the ICD-10 classification system. The NIS is an all-payer, survey-weighted, inpatient database estimating 37 million annual U.S. hospitalizations managed by the Healthcare Cost and Utilization Project (HCUP). Primary study outcomes were prevalence of comorbid vasculitis, mortality, complications, and cost of care.Results:Of 1,351,670 patients undergoing PCI were identified, 410 (0.03%) had diagnosis of ANCA-vasculitis. AV patients were similar to non-AV patients in distribution of gender, race, and median household income. AV patients were older (70.9 vs 65.2 years, P<0.001) and more likely to utilize Medicare (78% vs 53%, P<0.005). AV patients were more likely to present with non-ST segment myocardial infarction (NSTEMI) (57.3% vs 41.5%, P<0.005) and less likely to present with ST-elevation myocardial infarction (NSTEMI) (18.3% vs 31.3%, P<0.05). AV patients had similar adjusted mortality (6.1% vs 2.6%, aOR: 2.1, P=0.8), cost of care ($32,985 vs $25,767, β = 0.02, P=0.7), and length of hospitalization (6.0 vs 3.9, IRR: 1.2, P=0.13).Conclusion:The presence of ANCA-associated vasculitis did not appear to negatively impact inpatient clinical outcomes or utilization of care among patients undergoing PCI in the United States. Cost of care was not increased, in contrast to an increase cost of care when small, medium, and large vasculitides are grouped together. The greater proportion of NSTEMI patients among those with AAV corresponds with a growing body of literature implicating inflammatory processes in the pathogenesis of certain forms of myocardial infarction meriting further investigation.References:[1]Misra DP, Shenoy SN. Cardiac involvement in primary systemic vasculitis and potential drug therapies to reduce cardiovascular risk. Rheumatol Int. 2017;37(1):151-167. doi:10.1007/s00296-016-3435-1.[2]Amaya-Amaya J, Sarmiento-Monroy JC, Rojas-Villarraga A. Cardiovascular Involvement in Autoimmune Diseases. El Rosario University Press; 2013. Accessed February 1, 2021. https://www.ncbi.nlm.nih.gov/books/NBK459468/.[3]Bailey KL, Mantha A, Sanaiha Y, Mathias L, Benharash P, Ebrahimi R. Short-Term Outcomes After Percutaneous Coronary Intervention in Patients With Autoimmune Vasculitides. J Am Coll Cardiol. 2019;74(1):159-160. doi:10.1016/j.jacc.2019.04.051.Disclosure of Interests:None declared
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Rikhtegaran, Sahand, Mahdi Rahbar, Narmin Mohammadi, Shadieh Mowlaie, Siavash Savadi-Oskoee, Mohammad E. Ebrahimi et Tahereh Pirzadeh. « Effect of 15% Carbamide Peroxide on the Surface Roughness and Adhesion of Streptococcus mutans to Microhybrid Composite Resin and Giomer ». World Journal of Dentistry 8, no 4 (2017) : 288–95. http://dx.doi.org/10.5005/jp-journals-10015-1452.
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ABSTRACT Introduction Adhesion of bacteria, especially Streptococcus mutans (S. mutans), to the surface of tooth restorations is a factor in the etiology of secondary caries. Given the ever-increasing popularity of bleaching procedures, the aim of the present study was to evaluate adhesion of S. mutans and surface roughness (SR) of microhybrid composite resin and giomer subsequent to the application of 15% carbamide peroxide. Materials and methods Twenty disk-shaped samples were prepared from each material, measuring 8 mm in diameter and 2 mm in thickness. Then, the samples of each material were divided into two groups (n = 10): (a) microhybrid without bleaching; (b) microhybrid with bleaching; and (c) giomer without bleaching; and (d) giomer with bleaching. The samples in groups I and III were immersed in artificial saliva for 14 days without any bleaching procedure; the samples in groups II and IV underwent a bleaching procedure on their polished surfaces with 15% carbamide peroxide for 14 days (4 hours of bleaching and 20 hours of immersion in artificial saliva). The SR of all the samples was determined with the use of a profilometer. The samples were added to the culture medium after 4 hours of placement in a microbial suspension at 37°C; after 24 hours of incubation at 37°C, the bacterial counts, indicating the number of bacteria adhering to the surface, were determined by counting them in the plates containing the solid culture medium. Results The type of the restorative material had a significant effect on SR, with greater SR in giomer (p = 0.03). However, bleaching had no significant effect on SR (p = 0.099). In relation to the rate of bacterial adhesion (BA), both the types of the restorative materials and bleaching procedures were significantly effective; in this context, there was more BA in microhybrid composite resin samples that did not undergo bleaching (p < 0.001). Bleaching resulted in the adhesion of S. mutans to the surface of both materials decrease. Pearson's correlation coefficient did not reveal any correlation between BA and SR (p = 0.42). Conclusion The BA was higher in microhybrid composite resin, and SR was higher in giomer. The BA was higher in samples that did not undergo a bleaching procedure. Clinical significance There is no change in the SR of microhybrid composite resin and giomer after application of 15% carbamide peroxide; therefore, it is not necessary to polish or replace these restorative materials after bleaching. In addition, use of 15% carbamide peroxide does not increase caries risk. How to cite this article Mohammadi N, Mowlaie S, Savadi- Oskoee S, Ebrahimi ME, Rikhtegaran S, Rahbar M, Pirzadeh T. Effect of 15% Carbamide Peroxide on the Surface Roughness and Adhesion of Streptococcus mutans to Microhybrid Composite Resin and Giomer. World J Dent 2017;8(4):288-295.
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Dubrot, Juan, Peter P. Du, Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Arnav Mehta, Samuel S. Freeman et al. « Abstract 3610 : In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer ». Cancer Research 82, no 12_Supplement (15 juin 2022) : 3610. http://dx.doi.org/10.1158/1538-7445.am2022-3610.
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Abstract The immune system can eliminate tumors, but checkpoints enable tumors to escape immune destruction. Here, we report the systematic identification of immune evasion mechanisms using genome-scale in vivo CRISPR screens in eight murine cancer models treated with immune checkpoint blockade (ICB). We identify and validate previously unreported immune evasion genes and identify key immune inhibitory checkpoints that have a conserved role across several cancer models, such as the non-classical MHC-I molecule Qa-1b/HLA-E, which scores as the top overall sensitizing hit across all screens. Surprisingly, we find that loss of IFNγ signaling by tumor cells sensitizes 6 of 8 cancer models to ICB. While IFN-mediated inflammation has been associated with response to ICB, there have also been reports of ICB-resistance driven by IFN sensing. However, several divergent mechanisms have been proposed to explain the inhibitory effect of tumor IFN sensing, leading to uncertainty about how this key immune signaling pathway is regulating anti-tumor immunity in different contexts. Using in vivo screening data, transcriptional profiling, and genetic interaction studies, we reveal that the immune-inhibitory effects of tumor IFN sensing are the direct result of tumor upregulation of classical and non-classical MHC-I genes. The interferon-MHC-I axis can inhibit anti-tumor immunity through two mechanisms: first, upregulation of classical MHC-I inhibits the cytotoxicity of natural killer cells, which are activated by ICB. Second, IFN-mediated upregulation of Qa-1b directly inhibits cytotoxicity by effector CD8+ T cells via the NKG2A/CD94 receptor, which is induced on CD8+ T cells by ICB. Finally, we show that high interferon-stimulated gene expression in patients is associated with decreased survival in RCC and poor response to ICB in melanoma. Our study establishes a unifying mechanism to explain the inhibitory role of tumor IFN sensing, revealing that IFN-mediated upregulation of classical and non-classical MHC-I inhibitory checkpoints can facilitate immune escape. Citation Format: Juan Dubrot, Peter P. Du, Sarah Kate Lane-Reticker, Emily A. Kessler, Audrey J. Muscato, Arnav Mehta, Samuel S. Freeman, Peter M. Allen, Kira E. Olander, Kyle M. Ockerman, Clara H. Wolfe, Fabius Wiesmann, Nelson H. Knudsen, Hsiao-Wei Tsao, Arvin Iracheta-Vellve, Emily M. Schneider, Andrea N. Rivera-Rosario, Ian C. Kohnle, Hans W. Pope, Austin Ayer, Gargi Mishra, Margaret D. Zimmer, Sarah Y. Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T. Frederick, Genevieve M. Boland, W. Nicholas Haining, David E. Root, John G. Doench, Nir Hacohen, Kathleen B. Yates, Robert T. Manguso. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3610.
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Phillip Bell, Dean. « Aron Di Leone Leoni. La Nazione Ebraica Spagnola e Portoghese di Ferrara (1492–1559) : I suoi rapporti col governo ducale e la popolazione locale e i suoi legami con le Nazioni Portoghesi di Ancona, Pesaro e Venezia. Ed. Laura Graziani Secchieri. 2 vols. Storia dell’ebraismo in Italia ; Studi e testi 26. Florence : Leo S. Olschki, 2011. xxxviii + 1,308 pp. €120. ISBN : 978–88–222–6005–5. » Renaissance Quarterly 65, no 4 (2012) : 1269–71. http://dx.doi.org/10.1086/669412.
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Ramgopal, Moti, Peter Ruane, Yongwu Shao, Ramin Ebrahimi, Alex Kintu, Christoph C. Carter, Moupali Das et al. « 854. Long-term Outcomes of Participants on F/TAF for Pre-Exposure Prophylaxis : Results for 144 Weeks of Follow-Up in the DISCOVER Trial ». Open Forum Infectious Diseases 8, Supplement_1 (1 novembre 2021) : S517—S518. http://dx.doi.org/10.1093/ofid/ofab466.1049.
Texte intégralRésumé :
Abstract Background In DISCOVER, a multinational randomized controlled trial, F/TAF demonstrated noninferior efficacy compared to F/TDF for HIV prevention with improved bone mineral density and renal safety biomarkers at the primary endpoint (when all participants had reached 48 weeks and 50% had reached 96 weeks) and at week (W) 96, the end of the blinded phase. We now report W144 outcomes for participants who were randomized to F/TAF and continued F/TAF in the open-label extension (OLE) phase. Methods All participants who completed the randomized blinded phase could opt to receive F/TAF for at least 48 weeks in the OLE phase. We evaluated HIV incidence in participants on F/TAF through W144 and assessed changes in hip and spine bone mineral density (BMD) and in glomerular function (eGFR) from baseline to W144. Results 2,080 of the 2,694 participants initially randomized to F/TAF opted into the OLE phase, and 1,933 were still on study drug through W144, thereby leading to a total of 7,885 person-years (PY) of follow-up on F/TAF. Eight participants taking F/TAF acquired HIV in the blinded phase and 3 in the OLE phase. Dried blood spot analyses on the 3 OL infections found tenofovir diphosphate levels consistent with low adherence. Genotypic resistance testing showed no relevant resistance mutations for the 3 new infections. Among participants taking F/TAF, HIV incidence was 0.16/100 PY (95% CI 0.06-0.33) at the primary endpoint, 0.16/100 PY (95% CI 0.07-0.31) through 96 weeks and 0.14/100 PY (95% CI 0.07-0.25) through 144 weeks. Participants taking F/TAF had increases in hip BMD (mean percentage change +0.54%) and in spine BMD (mean percentage change +1.02%) from baseline to W144 (Figure 1). Median eGFR increased over 144 weeks, with a median increase of 2.6 mL/min from baseline to week 144. Participants in the F/TAF arm gained a median 2.3 kg (IQR -0.9-5.8) over 3 years of follow up. Figure 1. Changes in hip and spine bone mineral density and in eGFR through Week 144 Conclusion The OLE of DISCOVER allowed for a long-term assessment (144 wks.) of F/TAF for PrEP. HIV incidence remained low with BMD and renal function parameters remaining stable through 144 weeks of follow-up. These findings demonstrate that F/TAF is a safe and effective option for long-term use in people who would benefit from PrEP. Disclosures Moti Ramgopal, MD FACP FIDSA, Abbvie (Scientific Research Study Investigator, Speaker’s Bureau)Gilead (Consultant, Scientific Research Study Investigator, Speaker’s Bureau)Janssen (Consultant, Scientific Research Study Investigator, Research Grant or Support, Speaker’s Bureau)Merck (Consultant, Scientific Research Study Investigator)ViiV (Consultant, Scientific Research Study Investigator, Speaker’s Bureau) Peter Ruane, MD, AbbVie (Consultant, Research Grant or Support)Allergan (Research Grant or Support)Gilead Sciences Inc. (Consultant, Research Grant or Support, Shareholder, Speaker’s Bureau)Merck (Consultant, Research Grant or Support)ViiV Healthcare (Consultant, Research Grant or Support) Yongwu Shao, PhD, Gilead Sciences Inc. (Employee, Shareholder) Ramin Ebrahimi, MSc, Gilead Sciences Inc. (Employee, Shareholder) Alex Kintu, MD, ScD, Gilead Sciences Inc. (Employee, Shareholder) Christoph C. Carter, MD, Gilead Sciences Inc. (Employee, Shareholder) Moupali Das, MD, Gilead Sciences Inc. (Employee, Shareholder) Jared Baeten, MD, PHD, Gilead Sciences Inc. (Employee, Shareholder) Cynthia Brinson, MD, Abbvie (Scientific Research Study Investigator)BI (Scientific Research Study Investigator)Gilead Sciences Inc. (Scientific Research Study Investigator, Advisor or Review Panel member, Speaker’s Bureau, Personal fees)GSK (Scientific Research Study Investigator)Novo Nordisk (Scientific Research Study Investigator)ViiV Healthcare (Scientific Research Study Investigator, Advisor or Review Panel member, Speaker’s Bureau) Peter Shalit, MD, PhD, Abbvie (Grant/Research Support)Gilead Sciences (Consultant, Grant/Research Support, Speaker’s Bureau)Glaxo Smithkline (Consultant, Grant/Research Support)Janssen (Consultant, Grant/Research Support, Speaker’s Bureau)Merck (Grant/Research Support, Speaker’s Bureau)Thera (Speaker’s Bureau)ViiV Healthcare (Speaker’s Bureau) Karam Mounzer, MD, Epividian (Advisor or Review Panel member)Gilead Sciences Inc. (Consultant, Scientific Research Study Investigator, Research Grant or Support, Speaker’s Bureau)Janssen (Consultant, Research Grant or Support, Speaker’s Bureau)Merck (Research Grant or Support, Speaker’s Bureau)ViiV Healthcare (Consultant, Speaker’s Bureau)
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Borghesi, Francesco. « Menahem ben Benjamin Recanati. Menahem Recanati, Commentary on the Daily Prayers Flavius Mithridates’ Latin translation, the Hebrew text, and an English version. Kabbalistic Library of Giovanni Pico della Mirandola 3. 2 vols. Ed. and trans., Giacomo Corazzol. Turin : Nino Aragno Editore, 2008. 709 + 151 pp. index. bibl. €70. ISBN : 978–8884193827. - Michela Andreatta. Gersonide : Commento al Cantico dei cantici nella traduzione ebraico-latina di Flavio Mitridate. Centro Internazionale di Cultura “Giovanni Pico Della Mirandola,” Studi Pichiani 14. Florence : Leo S. Olschki, 2009. xiii + 206 pp. index. tbls. bibl. €25. ISBN : 978–88–222–5905–9. » Renaissance Quarterly 64, no 1 (2011) : 269–71. http://dx.doi.org/10.1086/660440.
Texte intégral
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Azminah, Suhartini Nurul. « Movie Media with Islamic Character Values to shaping “Ahlaqul Karimah" in Early Childhood ». JPUD - Jurnal Pendidikan Usia Dini 14, no 1 (30 avril 2020) : 185–200. http://dx.doi.org/10.21009/141.13.
Texte intégralRésumé :
ABSTRACT: Character education in Islam has its own style, as well as the character values con- tained in various learning media for early childhood. This study is a follow-up study to find the effect of Movie Media with Islamic Character Values (M-ICV) in shaping "Ahlaqul Karimah" in early childhood. Using an experimental method with a control class, which involved 19 respondents of early childhood. Data shows that the ttest < t table (0.75 < 2.110), meaning that there is a significant difference in effect between the experimental class and the control class. The results conclude that M-ICV is able to form a child's "Ahlakul Karimah" slowly, because the child likes various movies with content interesting and easy to imitate. The implications of further research on movie content development for children are able to develop other aspects of children's development.
Keywords: Early Childhood, Ahlakul karimah, Islamic Character Values Movie Media
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Ahmad Sabri. « Trends of “Tahfidz House” Program in Early Childhood Education ». JPUD - Jurnal Pendidikan Usia Dini 14, no 1 (30 avril 2020) : 71–86. http://dx.doi.org/10.21009/jpud.141.06.
Texte intégralRésumé :
The enthusiasm in the Tahfidz House (TH) education program especially for children shows an increasing trend in Padang, a modeling city in developing Islāmic character for children. The purpose of this study was to investigate the Tahfidz House program trends development in early childhood in Padang. This study uses qualitative methods with data collection tools, namely inter- views, direct observation, and document analysis. The results showed that: First, the Tahfidz House program attracted public interest because it offered dimensions of character formation such as in- creasing Intelligence Quotient, Emotional Quotient, and Spiritual Quotient. Second, there is a theo- logical reason in the landscape of local people to think that the Qur'an offers a blessing concept in our lives. Third, Tahfidz House existences as non-formal education has two dominant affiliations, namely pure education and based on market interests or capitalization.
Keywords: Early Childhood Education, Tahfidz House Program, Market Interest
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Almeida, Maria Tereza Carvalho, Fernanda Alves Maia, Maria das Mercês Borém Correa Machado, Filipe Alves Souza, Victor Bruno da Silva, Mateus Almeida de Carvalho et João Felício Rodrigues Neto. « Desenvolvimento docente : avaliação de uma experiência em um curso de Medicina (Teacher development : evaluation of an experience in a Medical course) ». Revista Eletrônica de Educação 13, no 1 (5 janvier 2019) : 306. http://dx.doi.org/10.14244/198271992635.
Texte intégralRésumé :
The objective of this study was to evaluate the actions offered in the Teacher Development Program from the perceptions of the teachers of the medical course of a public university that has been working with active teaching and learning methods since 2002. After each action of the program, an evaluation instrument was applied to the participants, and the answers were submitted to content analysis and then organized into three categories: infrastructure and logistics, the teaching-learning strategies and the developed content. Teachers highlight the importance of organization and planning of activities and the environment in which these actions are developed; they emphasize the importance of using teaching–learning strategies that allow greater re?ection on own practice and the integration of theory and practice. They point out that the themes proposed were timely and necessary, they recognize the importance of being in development, they talk about the motivation from the experiences lived. It is concluded that the Teacher Development is a process through which the teacher is in transformation, through a conscious and constant reflection of his own practice. This process can be promoted by institutional investments and by the regulatory mechanisms of institutions, constituted of an evaluation referenced in objective indicators, consistent with the goals to be achieved. In this sense, it is necessary to invest in permanent education, because long-term programs allow the development of the teacher´s and the institution´s needs.ResumoO objetivo deste estudo foi avaliar as ações oferecidas em um Programa de Desenvolvimento Docente a partir da percepção dos professores do curso de medicina de uma universidade pública que utiliza métodos ativos de ensino-aprendizagem desde 2002. Após cada ação do programa, um instrumento de avaliação foi aplicado aos participantes, e respostas foram submetidas à análise do conteúdo e em seguida foram organizadas em três categorias: infraestrutura e logística, estratégias de ensino-aprendizagem utilizadas, e conteúdo desenvolvido. Os professores destacam a importância da organização e planejamento das atividades e do ambiente em que essas ações se desenvolveram; Enfatizam a importância de utilizar estratégias de ensino-aprendizagem que possibilitem maior reflexão sobre a própria prática e a integração da teoria e a prática. Apontam que os temas propostos foram oportunos e necessários, reconhecem a importância de estarem em desenvolvimento, falam sobre a motivação a partir das experiências vivenciadas. Conclui-se que o Desenvolvimento Docente é um processo pelo qual o professor está em transformação, por meio de uma re?exão consciente e constante de sua própria prática. Esse processo pode ser promovido pelos investimentos institucionais e pelos mecanismos reguladores das instituições constituídos por uma avaliação referenciada em indicadores objetivos, coerentes com as metas a serem alcançadas. Nesse sentido, é necessário investir na educação permanente, pois os programas em longo prazo permitem trabalhar as necessidades do professor e da instituição.ResumenEl objetivo de este estudio fue evaluar las acciones ofrecidas en un Programa de Desarrollo Docente a partir de la percepción de los profesores del curso de medicina de una universidad pública que utiliza métodos activos de enseñanza - aprendizaje desde 2002. Después de cada acción del programa, un instrumento de evaluación se aplicó a los participantes, y las respuestas se sometieron al análisis del contenido y luego se organizaron en tres categorías: infraestructura y logística, estrategias de enseñanza - aprendizaje utilizadas, y contenido desarrollado. Los profesores destacan la importancia de la organización y planificación de las actividades y del ambiente en que esas acciones se desarrollaron; Enfatizan la importancia de utilizar estrategias de enseñanza - aprendizaje que posibiliten una mayor reflexión sobre la propia práctica y la integración de la teoría y la práctica. Se señalan que los temas propuestos fueron oportunos y necesarios, reconocen la importancia de estar en desarrollo, hablan sobre la motivación a partir de las experiencias vivenciadas. Se concluye que el Desarrollo Docente es un proceso por el cual el profesor está en transformación, por medio de una re?exión consciente y constante de su propia práctica. Este proceso puede ser promovido por las inversiones institucionales y por los mecanismos reguladores de las instituciones constituidos por una evaluación referenciada en indicadores objetivos, coherentes con las metas a ser alcanzadas. 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Saha, Sumanta. « The prevalence and risk of missing outcome data in prenatal vitamin D supplemented gestational diabetes mellitus patients : a systematic review and meta-analysis protocol ». Journal of Ideas in Health 3, no 3 (22 octobre 2020) : 217–21. http://dx.doi.org/10.47108/jidhealth.vol3.iss3.67.
Texte intégralRésumé :
Background: Missing outcome data in clinical trials are important determinants of internal validity; however, its burden and risk in gestational diabetes mellitus (GDM) mothers supplemented with vitamin D remain poorly studied. Therefore, a systematic review and meta-analysis protocol is proposed here to study it.
Methods: The English language publications, irrespective of its publication date, will be searched in electronic databases for randomized controlled trials studying the above outcome. The eligible trials will undergo the risk of bias assessment by the Cochrane tool. Data on its trial design, population characteristics, interventions compared, and the outcome will be abstracted. The prevalence and incidence (in risk ratio) of missing outcome data will be estimated meta-analytically. The statistical heterogeneity assessment will include the use of Chi2 and I2 statistics. For the explanation of any substantial heterogeneity, a meta-regression analysis will ensue. The statistical significance will be determined at P <0.05 and 95% CI. All analyses will be done in Stata statistical software. If the quantitative analysis is not possible, narrative reporting will happen.
Results: The reporting of the review will follow the PRISMA guideline. Statistically significant pairwise meta-analysis finding's grading will occur by the GRADE approach.
Conclusion: The proposed review will estimate the prevalence of missing outcome data in vitamin D supplemented GDM mothers in clinical trials and compare its risk with the placebo recipients.
PROSPERO registration ID: CRD42020180634
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Priyanti, Nita, et Jhoni Warmansyah. « The Effect of Loose Parts Media on Early Childhood Naturalist Intelligence ». JPUD - Jurnal Pendidikan Usia Dini 15, no 2 (30 novembre 2021) : 239–57. http://dx.doi.org/10.21009/jpud.152.03.
Texte intégralRésumé :
Naturalist intelligence of early childhood has a very big role in today's modern age as the basis for children to have environmental-loving behaviour. The purpose of this study was to determine the effect of Loose Parts learning media on the naturalist intelligence. This study uses a quasi-experimental method with data collection techniques through multiple intelligence tests of children's intelligence instruments. The subjects of this study were 17 children aged 5-6 years. The results showed that there was a significant effect of giving Loose Parts media to the naturalist intelligence of early childhood after seeing a difference between pre-test and post-test. The use of natural-based Loose Parts media can be a means for teachers to increase children's naturalist intelligence in kindergarten and be a development of conventional media made from manufacturers in the learning cycle so far. For further research, it is recommended to look at the influence of other factors on naturalist intelligence in early childhood.
Keywords: Early Childhood, Loose Parts, Naturalist Intelligence
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Peters, Marion G., H. W. Hann, Paul Martin, E. Jenny Heathcote, P. Buggisch, R. Rubin, M. Bourliere et al. « Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B 1 1The Adefovir Dipivoxil International 461 Study Group includes the following : N. Afdhal (Beth Israel Deaconess Medical Center, Boston, MA) ; P. Angus (Austin and Repatriation Medical Centre, Melbourne, Australia) ; Y. Benhamou (Hopital La Pitie Salpetriere, Paris, France) ; M. Bourliere (Hopital Saint Joseph, Marseille, France) ; P. Buggisch (Universitaetsklinikum Eppendorf, Department of Medicine, Hamburg, Germany) ; P. Couzigou (Hopital Haut Leveque, Pessac, France) ; P. Ducrotte and G. Riachi (Hopital Charles Nicolle, Rouen, France) ; E. Jenny Heathcote (Toronto Western Hospital, Toronto, Ontario, Canada) ; H. W. Hann (Jefferson Medical College, Philadelphia, PA) ; I. Jacobson (New York Presbyterian Hospital, New York, NY) ; K. Kowdley (University of Washington Hepatology Center, Seattle, WA) ; P. Marcellin (Hopital Beaujon, Clichy, France) ; P. Martin (Cedars-Sinai Medical Center, Los Angeles, CA) ; J. M. Metreau (Centre Hospitalier Universitaire Henri Mondor, Creteil, France) ; M. G. Peters (University of California, San Francisco, San Francisco, CA) ; R. Rubin (Piedmont Hospital, Atlanta, GA) ; S. Sacks (Viridae Clinical Sciences, Inc., Vancouver, Canada) ; H. Thomas (St. Mary’s Hospital, London, England) ; C. Trepo (Hopital Hôtel Dieu, Lyon, France) ; D. Vetter (Hopital Civil, Strasbourg, France) ; C. L. Brosgart, R. Ebrahimi, J. Fry, C. Gibbs, K. Kleber, J. Rooney, M. Sullivan, P. Vig, C. Westland, M. Wulfsohn, and S. Xiong (Gilead Sciences, Inc., Foster City, CA) ; D. F. Gray (GlaxoSmithKline, Greenford, Middlesex, England) ; R. Schilling and V. Ferry (Parexel International, Waltham, MA) ; and D. Hunt (Covance Laboratories, Princeton, NJ). » Gastroenterology 126, no 1 (janvier 2004) : 91–101. http://dx.doi.org/10.1053/j.gastro.2003.10.051.
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Bonanno, Beatrice. « “E lui andò verso di lei” ? Uno studio sulle varianti testuali nel testo greco di Ruth 4,13 ». Bulletin de l’Académie Belge pour l’Étude des Langues Anciennes et Orientales, 24 février 2022, 41–51. http://dx.doi.org/10.14428/babelao.vol1011.2022.64823.
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Questo studio presenta e analizza le varianti testuali nel testo greco di Ruth 4,13 e ne ripercorre lo sviluppo storico. Ne emerge che il minus, attestato in B, 509, 707 e nella traduzione etiope sia da ricollegare al processo di traduzione del testo ebraico nella sua forma greca. Nel processo di trasmissione di quest’ultima, poi, il plus in 4,13 sarebbe stato introdotto secondo due tradizioni testuali differenti, che rivelano la variabilità del testo e della sua trasmissione. Il manoscritto A, le recensioni hexaplarica e R correggerebbero il minus rendendo il testo il più fedele possibile alla Vorlage ebraica, mentre la recensione lucianea sembrerebbe revisionare il testo di A e delle recensioni hexaplarica e R, per renderlo stilisticamente più conforme al greco e armonizzandolo a Ruth 1,4.
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Fu, Zening, Christopher C. Abbott, Jeremy Miller, Zhi-De Deng, Shawn M. McClintock, Mohammad S. E. Sendi, Jing Sui et Vince D. Calhoun. « Cerebro-cerebellar functional neuroplasticity mediates the effect of electric field on electroconvulsive therapy outcomes ». Translational Psychiatry 13, no 1 (6 février 2023). http://dx.doi.org/10.1038/s41398-023-02312-w.
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AbstractElectroconvulsive therapy (ECT) is the most effective treatment for severe depression and works by applying an electric current through the brain. The applied current generates an electric field (E-field) and seizure activity, changing the brain’s functional organization. The E-field, which is determined by electrode placement (right unilateral or bitemporal) and pulse amplitude (600, 700, or 800 milliamperes), is associated with the ECT response. However, the neural mechanisms underlying the relationship between E-field, functional brain changes, and clinical outcomes of ECT are not well understood. Here, we investigated the relationships between whole-brain E-field (Ebrain, the 90th percentile of E-field magnitude in the brain), cerebro-cerebellar functional network connectivity (FNC), and clinical outcomes (cognitive performance and depression severity). A fully automated independent component analysis framework determined the FNC between the cerebro-cerebellar networks. We found a linear relationship between Ebrain and cognitive outcomes. The mediation analysis showed that the cerebellum to middle occipital gyrus (MOG)/posterior cingulate cortex (PCC) FNC mediated the effects of Ebrain on cognitive performance. In addition, there is a mediation effect through the cerebellum to parietal lobule FNC between Ebrain and antidepressant outcomes. The pair-wise t-tests further demonstrated that a larger Ebrain was associated with increased FNC between cerebellum and MOG and decreased FNC between cerebellum and PCC, which were linked with decreased cognitive performance. This study implies that an optimal E-field balancing the antidepressant and cognitive outcomes should be considered in relation to cerebro-cerebellar functional neuroplasticity.
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Cojocaru, Andrei Victor. « O paralelă între primul verset al genezei biblice, poemul „Grădina Tainei” și Arborele Sephirotic al Kabbalei ». Diacronia, no 15 (26 septembre 2022). http://dx.doi.org/10.17684/i15a207ro.
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Acest articol propune un studiu situat la granița dintre literatura comparată și hermeneutica simbolurilor. Deși literatura tradițională a Orientului Apropiat oferă numeroase posibilități de abordare, contextul analizei se va focaliza mai ales asupra unei paralele între reprezentarea Arborelui Sephirotic al Kabbalei (numit și Pomul Vieții) și anumite versuri din poemul „Grădina Tainei” scris de Mahmūd Shabestarī. Totodată, vom utiliza ca liant între cele două contexte și o interpretare simbolică a primului verset al genezei biblice. Alături de evidențierea cîtorva particularități pe care le presupune decriptarea alfabetului ebraic, acest demers își propune o abordare care să faciliteze tranziția de la un tip de Kabbala intelectuală la o receptare care ține de Kabbala intuitivă. În consecință, literatura comparată apare mai mult ca un pretext pentru contextualizarea metodei de abordare, precum și pentru prezentarea unor exemple ilustrative.
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Setty, Yaki. « eBrain : a Three Dimensional Simulation Tool to Study Drug Delivery in the Brain ». Scientific Reports 9, no 1 (16 avril 2019). http://dx.doi.org/10.1038/s41598-019-42261-3.
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Aguiar, Marcelo, et Walter Moreira. « Combinatorics of the Free Baxter Algebra ». Electronic Journal of Combinatorics 13, no 1 (22 février 2006). http://dx.doi.org/10.37236/1043.
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We study the free (associative, non-commutative) Baxter algebra on one generator. The first explicit description of this object is due to Ebrahimi-Fard and Guo. We provide an alternative description in terms of a certain class of trees, which form a linear basis for this algebra. We use this to treat other related cases, particularly that in which the Baxter map is required to be quasi-idempotent, in a unified manner. Each case corresponds to a different class of trees. Our main focus is on the underlying combinatorics. In several cases, we provide bijections between our various classes of trees and more familiar combinatorial objects including certain Schröder paths and Motzkin paths. We calculate the dimensions of the homogeneous components of these algebras (with respect to a bidegree related to the number of nodes and the number of angles in the trees) and the corresponding generating series. An important feature is that the combinatorics is captured by the idempotent case; the others are obtained from this case by various binomial transforms. We also relate free Baxter algebras to Loday's dendriform trialgebras and dialgebras. We show that the free dendriform trialgebra (respectively, dialgebra) on one generator embeds in the free Baxter algebra with a quasi-idempotent map (respectively, with a quasi-idempotent map and an idempotent generator). This refines results of Ebrahimi-Fard and Guo.
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Trapani, Alessandra, Francesco Jamal Sheiban, Elisa Bertone, Serena Chiosso, Luca Colombo, Matteo D'Andrea, Francesco De Santis et al. « Reproducing a decision-making network in a virtual visual discrimination task ». Frontiers in Integrative Neuroscience 16 (10 août 2022). http://dx.doi.org/10.3389/fnint.2022.930326.
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We reproduced a decision-making network model using the neural simulator software neural simulation tool (NEST), and we embedded the spiking neural network in a virtual robotic agent performing a simulated behavioral task. The present work builds upon the concept of replicability in neuroscience, preserving most of the computational properties in the initial model although employing a different software tool. The proposed implementation successfully obtains equivalent results from the original study, reproducing the salient features of the neural processes underlying a binary decision. Furthermore, the resulting network is able to control a robot performing an in silico visual discrimination task, the implementation of which is openly available on the EBRAINS infrastructure through the neuro robotics platform (NRP).
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Chirilă, Adina. « „Au greșit” în Iv, 4, 11 ; de ce nu și în Pv, 30, 30 ? Implicit, despre limite filologice și acceptarea lor ». Diacronia, no 7 (27 avril 2018). http://dx.doi.org/10.17684/i7a105ro.
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Existența termenului furnicoleu (gr. μυρμηκολέων) în Iov, 4, 11, în textul biblic de tradiție ortodoxă, pe linia neabătută a LXX, a părut în răstimpuri bizară și a intrigat în suficientă măsură încît să fie abordată ca problemă textologică în cîteva articole și studii, unele dintre ele ample și bine documentate, în ultimul secol. Concluzia acestora este că ne aflăm în fața unei simple greșeli de traducere: traducătorul evreu elenizat al LXX a ratat echivalentul ebr. ַׁל ֭י ִש (layish [lah’-yish]) ‘un leu’ din secvența originară a povestirii ebraice a lui Iov, producînd în schimb un termen singular în textul sacru, obscur. Redeschizînd chestiunea, studiul de față propune, pe baza unor argumente și analogii de natură lingvistică, o altă lecțiune decît cele care au fost presupuse, îndeobște, pentru gr. μυρμηκολέων, care exclude aflarea în eroare a vechiului traducător. Mai mult decît atît însă, prin critica și rezervele pe care le formulează față de soluțiile precedente și față de raționamentele care au dus la ele, studiul reamintește de necesitatea aplicării unor judecăți și cîntăriri lucide ale argumentelor ce par a favoriza o anumită poziție într-un demers de natură filologică.