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Tang, Yin, Hang Yu, Zi Wang, Maohui Luo et Chaoen Li. « Validation of the Stolwijk and Tanabe Human Thermoregulation Models for Predicting Local Skin Temperatures of Older People under Thermal Transient Conditions ». Energies 13, no 24 (10 décembre 2020) : 6524. http://dx.doi.org/10.3390/en13246524.
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Human thermoregulation models can predict human thermal responses to evaluate thermal comfort and help create a healthy environment, while their applicability to older people has not been sufficiently validated. This study aimed to evaluate the performance of the Stolwijk model and the Tanabe model for predicting older people’s mean and local skin temperatures under thermal transient conditions. Eighteen healthy older people were recruited and exposed to transient environments including neutral (26 °C), low-temperature (23 and 21 °C), and high-temperature (29 and 32 °C) conditions. The local skin temperatures of the subjects were measured and compared to predictions of the Stolwijk model and the Tanabe model. The results revealed that the Stolwijk model and the Tanabe model could accurately predict the mean skin temperature of older people under neutral and high-temperature conditions, while their predictive accuracy declined under low-temperature conditions. Increased deviations were observed in the predictions of local skin temperatures for all conditions. This work attempted to provide an understanding of older people’s thermal response characteristics under transient conditions and to inspire the improvement of thermoregulation models for older people.
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Haitsma Mulier, E. O. G. « P. Hecht, A. Hoogenboom, Chr. Stolwijk, Kunstgeschiedenis in Nederland. Negen opstellen ». BMGN - Low Countries Historical Review 115, no 1 (1 janvier 2000) : 146. http://dx.doi.org/10.18352/bmgn-lchr.5185.
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Mack, Gary W. « Hypothalamic control of body temperature : insights from the past ». Journal of Applied Physiology 97, no 5 (novembre 2004) : 1593–94. http://dx.doi.org/10.1152/classicessays.00011.2004.
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This essay looks at the historical significance of three APS classic papers that are freely available online: Hammel HT, Hardy JD, and Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol 198: 481—486, 1960 ( http://ajplegacy.physiology.org/cgi/reprint/198/3/481 ). Hammel HT, Jackson DC, Stolwijk JAJ, Hardy JD, and Strømme SB. Temperature regulation by hypothalamic proportional control with an adjustable set point. J Appl Physiol 18: 1146—1154, 1963 ( http://jap.physiology.org/cgi/reprint/18/6/1146 ). Hellstrøm B and Hammel HT. Some characteristics of temperature regulation in the unanesthetized dog. Am J Physiol 213: 547—556, 1967 ( http://ajplegacy.physiology.org/cgi/reprint/213/2/547 ).
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Mack, Gary W. « Hypothalamic control of body temperature : insights from the past ». American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no 5 (novembre 2004) : R1012—R1013. http://dx.doi.org/10.1152/classicessays.00011a.2004.
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This essay looks at the historical significance of three APS classic papers that are freely available online: Hammel HT, Hardy JD, and Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol 198: 481-486, 1960 ( http://ajplegacy.physiology.org/cgi/reprint/198/3/481 ). Hammel HT, Jackson DC, Stolwijk JAJ, Hardy JD, and Strømme SB. Temperature regulation by hypothalamic proportional control with an adjustable set point. J Appl Physiol 18: 1146-1154, 1963 ( http://jap.physiology.org/cgi/reprint/18/6/1146 ). Hellstrøm B and Hammel HT. Some characteristics of temperature regulation in the unanesthetized dog. Am J Physiol 213: 547-556, 1967 ( http://ajplegacy.physiology.org/cgi/reprint/213/2/547 ).
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Wakamatsu, Hidetoshi, et Lu Gaohua. « Adaptive control of brain temperature for brain hypothermia treatment using Stolwijk-Hardy model ». Artificial Life and Robotics 8, no 2 (juin 2004) : 214–21. http://dx.doi.org/10.1007/bf02678894.
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Wakamatsu, Hidetoshi, et Lu Gaohua. « Adaptive control of brain temperature for brain hypothermia treatment using Stolwijk-Hardy model ». Artificial Life and Robotics 8, no 2 (décembre 2004) : 214–21. http://dx.doi.org/10.1007/s10015-004-0310-z.
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Idria, Reza. « Aceh : Kisah datang dan terusirnya Belanda dan jejak yang ditinggalkan , by Anton Stolwijk ». Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 178, no 4 (10 novembre 2022) : 537–38. http://dx.doi.org/10.1163/22134379-17804015.
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Roelofsen, P., et P. Vink. « Improvement of the Stolwijk model with regard to clothing, thermal sensation and skin temperature ». Work 54, no 4 (1 septembre 2016) : 1009–24. http://dx.doi.org/10.3233/wor-162357.
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Tibbe, E. P. « Chr. Stolwijk, Uit de schilderswereld. Nederlandse kunstschilders in de tweede helft van de negentiende eeuw ». BMGN - Low Countries Historical Review 115, no 2 (1 janvier 2000) : 328. http://dx.doi.org/10.18352/bmgn-lchr.5265.
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Kärger, Jörg, et Rustem Valiullin. « Transport-Optimized Nanoporous Materials for Mass Separation and Conversion as Designed by Microscopic Diffusion Measurement ». Diffusion Foundations 19 (novembre 2018) : 96–124. http://dx.doi.org/10.4028/www.scientific.net/df.19.96.
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Nanoporous materials find widespread application in material upgrading by separation (“molecular sieving”) and catalytic conversion. Mass transfer in these materials is a key phenomenon deciding about their technological performance. This chapter deals with the application of measurement techniques which are able to follow the diffusive fluxes of the guest molecules in such materials over “microscopic” distances, including the pulsed field gradient (PFG) technique of Nuclear Magnetic Resonance (NMR) and the techniques of microimaging by interference microscopy (IFM) and by IR microscopy (IRM). Microscopic measurement is a prerequisite for attaining unbiased information about the elementary steps of mass transfer and about their role within the overall process of technological exploitation. We dedicate this treatise to the memory of our dear and highly esteemed colleague Nicolaas Augustinus Stolwijk, notably in recognition of his manifold activities in the field of diffusion, distinguished by their impressively high standard in connecting the message of various techniques of measurement and in combining them to comprehensive views on quite intricate subjects.
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Roelofsen, Paul. « A comparison of the dynamic thermal sensation between the modified Stolwijk model and the Fiala thermal physiology and comfort (FPC) model ». Intelligent Buildings International 12, no 4 (9 février 2019) : 284–94. http://dx.doi.org/10.1080/17508975.2019.1571991.
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Wang, Rui, Chanjuan Mao, Changhua Jiang, Long Zhang, Siyuan Peng, Yi Zhang, Shucheng Feng et Feng Ming. « One Heat Shock Transcription Factor Confers High Thermal Tolerance in Clematis Plants ». International Journal of Molecular Sciences 22, no 6 (12 mars 2021) : 2900. http://dx.doi.org/10.3390/ijms22062900.
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Clematis plants play an important role in botanical gardens. Heat stress can destroy the activity, state and conformation of plant proteins, and its regulatory pathway has been well characterized in Arabidopsis and some crop plants. However, the heat resistance response mechanism in horticultural plants including Clematis has rarely been reported. Here, we identified a heat-tolerant clematis species, Clematis vitalba. The relative water loss and electrolytic leakage were significantly lower under heat treatment in Clematis vitalba compared to Stolwijk Gold. Differential expression heat-tolerant genes (HTGs) were identified based on nonparametric transcriptome analysis. For validation, one heat shock transcription factor, CvHSF30-2, extremely induced by heat stimuli in Clematis vitalba, was identified to confer tolerance to heat stress in Escherichia coli and Saccharomyces cerevisiae. Furthermore, silencing of HSF30-2 by virus-induced gene silencing (VIGS) led to heat sensitivity in tobacco and Clematis, suggesting that the candidate heat-resistant genes identified in this RNA-seq analysis are credible and offer significant utility. We also found that CvHSF30-2 improved heat tolerance of Clematis vitalba by elevating heat shock protein (HSP) expression, which was negatively regulated by CvHSFB2a. Taken together, this study provides insights into the mechanism of Clematis heat tolerance and the findings can be potentially applied in horticultural plants to improve economic efficiency through genetic approaches.
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Mehrer, Helmut. « Diffusion and Point Defects in Elemental Semiconductors ». Diffusion Foundations 17 (juillet 2018) : 1–28. http://dx.doi.org/10.4028/www.scientific.net/df.17.1.
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Elemental semiconductors play an important role in high-technology equipment used in industry and everyday life. The first transistors were made in the 1950ies of germanium. Later silicon took over because its electronic band-gap is larger. Nowadays, germanium is the base material mainly for γ-radiation detectors. Silicon is the most important semiconductor for the fabrication of solid-state electronic devices (memory chips, processors chips, ...) in computers, cellphones, smartphones. Silicon is also important for photovoltaic devices of energy production.Diffusion is a key process in the fabrication of semiconductor devices. This chapter deals with diffusion and point defects in silicon and germanium. It aims at making the reader familiar with the present understanding rather than painstakingly presenting all diffusion data available a good deal of which may be found in a data collection by Stolwijk and Bracht [1], in the author’s textbook [2], and in recent review papers by Bracht [3, 4]. We mainly review self-diffusion, diffusion of doping elements, oxygen diffusion, and diffusion modes of hybrid foreign elements in elemental semiconductors.Self-diffusion in elemental semiconductors is a very slow process compared to metals. One of the reasons is that the equilibrium concentrations of vacancies and self-interstitials are low. In contrast to metals, point defects in semiconductors exist in neutral and in charged states. The concentrations of charged point defects are therefore affected by doping [2 - 4].
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Gonzalez, R. R., T. M. McLellan, W. R. Withey, S. K. Chang et K. B. Pandolf. « Heat strain models applicable for protective clothing systems : comparison of core temperature response ». Journal of Applied Physiology 83, no 3 (1 septembre 1997) : 1017–32. http://dx.doi.org/10.1152/jappl.1997.83.3.1017.
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Gonzalez, R. R., T. M. McLellan, W. R. Withey, S. K. Chang, and K. B. Pandolf. Heat strain models applicable for protective clothing systems: comparison of core temperature response. J. Appl. Physiol. 83(3): 1017–1032, 1997.—Core temperature (Tc) output comparisons were analyzed from thermal models applicable to persons wearing protective clothing. The two models evaluated were the United States (US) Army Research Institute of Environmental Medicine (USARIEM) heat strain experimental model and the United Kingdom (UK) Loughborough (LUT25) model. Data were derived from collaborative heat-acclimation studies conducted by three organizations and included an intermittent-work protocol (Canada) and a continuous-exercise/heat stress protocol (UK and US). Volunteers from the US and the UK were exposed to a standard exercise/heat stress protocol (ambient temperature 35°C/50% relative humidity, wind speed 1 m/s, level treadmill speed 1.34 m/s). Canadian Forces volunteers did an intermittent-work protocol (15 min moderate work/15 min rest at ambient temperature of 40°C/30% relative humidity, wind speed ≈0.4 m/s). Each model reliably predicted Tc responses (within the margin of error determined by 1 root mean square deviation) during work in the heat with protective clothing. Models that are analytically similar to the classic Stolwijk-Hardy model serve as robust operational tools for prediction of physiological heat strain when modified to incorporate clothing heat-exchange factors.
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Tikuisis, P., R. R. Gonzalez et K. B. Pandolf. « Thermoregulatory model for immersion of humans in cold water ». Journal of Applied Physiology 64, no 2 (1 février 1988) : 719–27. http://dx.doi.org/10.1152/jappl.1988.64.2.719.
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The mathematical models of thermoregulation of Stolwijk and Hardy, and Montgomery were used to develop a model suitable for the simulation of human physiological responses to cold-water immersion. Data were obtained from experiments where 13 healthy male volunteers were totally immersed under resting and nude conditions for 1 h in water temperatures of 20 and 28 degrees C. At these temperatures, the mean measured rectal temperature (Tre) fell by approximately 0.9 and 0.5 degrees C, respectively, yet mean measured metabolic rate (M) rose by approximately 275 and 90 W for the low body fat group (n = 7) and 195 and 45 W for the moderate body fat group (n = 6). To predict the observed Tre and M values, the present model 1) included thermal inputs for shivering from the skin independent of their inclusion with the central temperature to account for the observed initial rapid rise in M, 2) determined a thermally neutral body temperature profile such that the measured and predicted initial values of Tre and M were matched, 3) confined the initial shivering to the trunk region to avoid an overly large predicted initial rate of rectal cooling, and 4) calculated the steady-state convective heat loss by assuming a zero heat storage in the skin compartment to circumvent the acute sensitivity to the small skin-water temperature difference when using conventional methods. The last three modifications are unique to thermoregulatory modeling.
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Feld, J., W. Saliba, N. Stein, T. Gazitt et D. Zisman. « POS0979 IMPROVING THE VALIDITY OF DIAGNOSTIC CODES AND POINT PREVALENCE ESTIMATION OF SPONDYLOARTHRITIS IN A LARGE POPULATION-BASED DATABASE ». Annals of the Rheumatic Diseases 81, Suppl 1 (23 mai 2022) : 798.1–798. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2444.
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BackgroundLarge population-based databases provide an opportunity to study the epidemiology of spondyloarthritis (SpA), however, strict validation procedures for case ascertainment are required (1).ObjectivesTo examine the validity of the ICD-9 codes of SpA in a large population-based database and to assess whether applying a specific algorithm would improve the case ascertainment. Finally, the point prevalence of SpA in the database was estimated using the validated algorithm.MethodsA Database of a large public health fund, which serves approximately 3.17 million enrollees older than 18 years old, was used. The database includes real-time input from pharmaceutical, medical and administrative operating systems. At first, the database was searched for all individuals who received an ICD-9 code of SpA, 720.0: 7200, 7201, 7202, 7208, 72081 and 72089. All medical records of a random sample of 169 patients were thoroughly reviewed by a rheumatologist. Based on the information available in the database, a decision was made whether SpA diagnosis was: 1) definite/probable SpA; 2) not SpA/; not enough data to verify the diagnosis of SpA. The positive predicted value (PPV) and 95% confidence interval (CI) were calculated. In order to improve the case ascertainment, a second validation process was performed using a specific algorithm. The algorithm applied was: a permanent ICD-9 code of SpA assigned by the family physician plus at least one of the following criteria: 1. At least one visit at a rheumatology clinic either in the community or at a hospital outpatient clinic; 2. A diagnosis of SpA given during a hospital admission; 3. A prescription fulfilled of an anti-Tumor Necrosis Factor agent or anti IL-17 agent. This algorithm was validated by two rheumatologists in a random sample of 182 cases. Finally, the point prevalence of SpA was estimated applying the validated algorithm.ResultsThe PPV of the ICD-9 codes of SpA was 44% (95%CI 36%-52%). The specific algorithm improved the PPV to 90% (95%CI 85%-94%). The concordance between the two rheumatologists was 91.3 95%CI (85.7-94.8). On the 31/12/2021, the validated algorithm identified 2892 live SpA patients older than 18 among a population of 3,167,329 enrollees in the database, reflecting a point prevalence of 0.09%, 94 patients per 100,000. Fifty one percent of the patients were male, 49% females. The point prevalence of males was 0.096%, and females - 0.087%. On the 31/12/2021, 6% of the patients were 18-29 years old, 34% 30-44 years old and 60% older than 45.ConclusionA specific algorithm can accurately identify patients with SpA in this large population-based database. The estimated prevalence of SpA is 0.09%. This figure is consistent with other population-based estimates (2).References[1]Wang R, Ward MM. Epidemiology of axial spondyloarthritis: an update. Curr Opin Rheumatol. 2018;30(2):137-43.[2]Stolwijk C, van Onna M, Boonen A, van Tubergen A. Global Prevalence of Spondyloarthritis: A Systematic Review and Meta-Regression Analysis. Arthritis Care Res (Hoboken). 2016;68(9):1320-31.Disclosure of InterestsNone declared
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Bilgin, E., U. Kalyoncu et L. Gossec. « SAT0367 EXTRA-ARTICULAR MANIFESTATIONS IN EARLY AXIAL SPONDYLOARTHRITIS : WHAT IS THEIR FREQUENCY ? A SYSTEMATIC LITERATURE REVIEW INCLUDING 2854 PATIENTS ». Annals of the Rheumatic Diseases 79, Suppl 1 (juin 2020) : 1130.1–1131. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3067.
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Background:Extra-articular manifestations (EAMs): psoriasis, uveitis and inflammatory bowel disease (IBD) are common in patients with established spondyloarthritis (SpA), with prevalences reported around 9%, 26% and 7 % respectively (1). However, data on the prevalence of EAMs are lacking in early axial SpA (axSpA).Objectives:The aim was to assess the prevalence of EAMs in early axSpA in the published literature.Methods:Systematic literature search on Pubmed MEDLINE up to 31.12.2019 with keywords referring to EAMs (uveitis and synonyms, psoriasis and synonyms or IBD and synonyms) and early axSpA (recent, young adult, young, untreated, inception) and selection by one reader of all full-text publications in English, describing the prevalence of at least one of the EAMs in patients with early axSpA, defined here as patients fulfilling ASAS, ESSG or Amor criteria and symptom duration of less than 6 years (as this was defined by authors as early disease). Patients’ age, axSpA symptom duration, sex, HLA-B27 status, and number of patients with EAMs were recorded by one reader using a predefined extraction sheet. For longitudinal studies, baseline data was recorded. Description of patients was analysed using weighted means. Prevalences in each study according to symptom duration were graphically reported, and pooled prevalences were calculated by meta-analysis of proportions, using a random-effects model and the DerSimonian & Laird method to derive the summary estimate.Results:Of 667 articles, 17 were relevant to the research question with prevalence data of psoriasis, uveitis and IBD available in 16, 17 and 15 articles, respectively (and most studies reporting several EAMs). Of the 17 articles, 14 were cohort studies and 3 were trials in early axSpA. A total of 2854 patients with early SpA was analyzed: weighted mean age 32.3±9.1 years (range 21-42 years), weighted mean axSpA symptom duration 20.7±11.1 months (range 8-68), 40.3 % were female, and 65.1% carried HLA-B27.The pooled prevalences of psoriasis, uveitis and IBD were respectively 8.9 % (95% CI 5.0, 13.8), 13.4% (95% CI 9.5, 17.8) and 3.5% (95% CI 1.7, 5.9) (Figure 1). There was a trend towards higher prevalences in patients with longer disease duration (Figure 2).Figure 1.Meta-analysis of prevalence of each EAMFigure 2.The prevalence of each EAM according to the symptom duration in early axSpAX axis: mean symptom duration (months). Y axis: prevalence (%) of an EAM. Diameter of bubbles is proportional to sample size of each article.Conclusion:Over the first years of axSpA, EAMs are frequent, in particular psoriasis and uveitis, with prevalences up to 30% in some studies. Compared to established axSpA, the EAM which was much less frequent was uveitis, which suggests the appearance of new cases over follow-up. Physicians need to screen carefully for EAMs right from the time of diagnosis, and need to repeat this screening over follow-up.References:[1]Stolwijk C et al. Prevalence of extra-articular manifestations in patients with ankylosing spondylitis: a systematic review and meta-analysis.Ann Rheum Dis. 2015;74(1):65–73Disclosure of Interests:Emre Bilgin: None declared, Umut Kalyoncu Consultant of: Abbvie, Amgen, Janssen, Lilly, Novartis, UCB, Laure Gossec Grant/research support from: Lilly, Mylan, Pfizer, Sandoz, Consultant of: AbbVie, Amgen, Biogen, Celgene, Janssen, Lilly, Novartis, Pfizer, Sandoz, Sanofi-Aventis, UCB
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Deodhar, A., K. Winthrop, R. Bohn, B. Chan, R. Suruki, J. Stark, H. Yun, S. Siegel, L. Chen et J. Curtis. « SAT0370 TUMOUR NECROSIS FACTOR INHIBITOR THERAPY DOES NOT REDUCE THE INCIDENCE OF COMORBIDITIES AND EXTRA-ARTICULAR MANIFESTATIONS IN ANKYLOSING SPONDYLITIS : AN ANALYSIS OF THREE US CLAIMS DATABASES ». Annals of the Rheumatic Diseases 79, Suppl 1 (juin 2020) : 1132.1–1133. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4201.
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Background:Comorbidities and extra-articular manifestations (EAMs) substantially increase disease burden and mortality risk in patients (pts) with ankylosing spondylitis (AS).1,2Tumour necrosis factor inhibitors (TNFi) are highly efficacious and effective in AS treatment (tx), and are used after inadequate response to non-steroidal anti-inflammatory drugs.3,4However, the impact of TNFi on the incidence of comorbidities and EAMs in pts with AS is unknown.5Objectives:To determine the incidence of comorbidities and EAMs in TNFi vs non-TNFi treated pts with AS in the US.Methods:This was a retrospective, observational cohort study using data from 3 healthcare insurance claims databases: Multi-Payer Claims Database (MPCD Optum Insight; 2007–2010), Truven MarketScan®(2010–2014) and US Medicare Fee-for-Service Claims database (2006–2014). Eligible pts: ≥20 years (yrs) for MarketScan/MPCD or ≥65 yrs for Medicare, had an AS diagnosis (≥2 International Classification of Disease, 9thversion [ICD-9] diagnosis codes of 720.0 from a rheumatologist) and ≥12 months’ continuous medical and pharmacy enrolment prior to AS diagnosis (AS index date). Pts with AS not receiving tx were excluded. Tx exposure was reported from the first date of a new prescription/administration of an AS tx (no prior exposure) after the AS index date. Crude incidence rates (IR; shown as cases/100 pt-yrs) were calculated for EAMs (uveitis, psoriasis [PSO], psoriatic arthritis [PsA], inflammatory bowel disease [IBD]), with follow-up until the earliest of: death, lost medical/pharmacy coverage, study period end, first outcome occurrence, tx switch/discontinuation. Hazard ratios (HRs) of comorbidities (hospitalised infection, solid cancers) and EAMs for propensity score (PS)-matched pt groups were calculated using Cox proportional hazard regression models. Pts with the specific comorbidity/EAM of interest prior to AS index date were excluded. PS analyses assessed probability of TNFi initiation vs non-TNFi tx and adjusted for factors including comorbidities and demographics. HRs with confidence intervals crossing 1 are not reported.Results:20,460 pts with AS were eligible (MPCD: 2,384; MarketScan: 9,032; Medicare: 9,044). In all databases, crude IR of EAMs were higher for TNFi vs non-TNFi treated pts (Figure 1). In the PS-matched cohort, incidences of hospitalised infections were lower in TNFi vs non-TNFi treated pts from the MarketScan and Medicare databases (Figure 2). Higher incidences of solid cancers and EAMs were observed in TNFi vs non-TNFi treated pts; Medicare data (Figure 2). A higher risk of PsA and PSO was seen in TNFi vs non-TNFi treated pts; MarketScan data (Figure 2). PS-matched cohort data from the MPCD database were non-significant.Conclusion:Despite strong efficacy in treating AS-related signs and symptoms, similar incidence of comorbidities and increased incidence of some EAMs (IBD, PSO/PsA, uveitis) was seen in TNFi vs non-TNFi treated pts in the PS-matched analyses. This may be due to channelling of pts with more severe AS to receive TNFi, despite the PS-matched analysis aiming to overcome this. Moreover, prior medical history of Medicare pts may not be captured in the database, as pts are typically older with longer disease durations. While these results confirm previous findings,6a prospective observational study is required to generalise to pts outside the US.References:[1]Stolwijk C. Ann Rheum Dis 2015;74:1373–8;[2]Bremander A. Arthritis Care Res 2011;63:550–6;[3]Braun J. Scand J Rheumatol 2005;34:178–90;[4]Ji X. Front Pharmacol 2019;10:1476;[5]Maxwell LJ. Cochrane Database Syst Rev 2015:CD005468;[6]Walsh J. J Pharm Health Serv Res 2018;9:115–21.Acknowledgments:This study was funded by UCB Pharma. Editorial services were provided by Costello Medical.Disclosure of Interests:Atul Deodhar Grant/research support from: AbbVie, Eli Lilly, GSK, Novartis, Pfizer, UCB, Consultant of: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myer Squibb (BMS), Eli Lilly, GSK, Janssen, Novartis, Pfizer, UCB, Speakers bureau: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myer Squibb (BMS), Eli Lilly, GSK, Janssen, Novartis, Pfizer, UCB, Kevin Winthrop Grant/research support from: Bristol-Myers Squibb, Consultant of: AbbVie, Bristol-Myers Squibb, Eli Lilly, Galapagos, Gilead, GSK, Pfizer Inc, Roche, UCB, Rhonda Bohn Consultant of: UCB Pharma, Benjamin Chan: None declared, Robert Suruki Employee of: UCB Pharma, Jeffrey Stark Employee of: UCB Pharma, Huifeng Yun Grant/research support from: Bristol-Myers Squibb and Pfizer, Sarah Siegel: None declared, Lang Chen: None declared, Jeffrey Curtis Grant/research support from: AbbVie, Amgen, Bristol-Myers Squibb, Corona, Crescendo, Genentech, Janssen, Pfizer, Roche and UCB Pharma, Consultant of: AbbVie, Amgen, Bristol-Myers Squibb, Corona, Crescendo, Genentech, Janssen, Pfizer, Roche and UCB Pharma
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Munir, Abdul, Satoru Takada et Takayuki Matsushita. « Re-evaluation of Stolwijk's 25-node human thermal model under thermal-transient conditions : Prediction of skin temperature in low-activity conditions ». Building and Environment 44, no 9 (septembre 2009) : 1777–87. http://dx.doi.org/10.1016/j.buildenv.2008.11.016.
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Lahrichi, S., K. Nassar et S. Janani. « POS0998 SPONDYLOARTHRITIS AND SLEEP DISORDERS ». Annals of the Rheumatic Diseases 80, Suppl 1 (19 mai 2021) : 767.2–768. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2909.
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Background:Spondyloarthropathies (SpA) are a group of chronic and progressive diseases, characterized in particular by a progressive stiffening of the spine, spreading to neighboring joints or to certain tissues, which could lead in the long term to progressive stiffening and functional impairment. This conditioncancauseinsomnia problems and impaired sleep quality.Objectives:To assess the impact of SpA on the quality of sleep.Methods:This is a retrospective study over a period of 4 years from January 2015 to December 2019, including all the medical records of patients with SpA followed in the Department of Rheumatology of the University Hospital of Ibn Rochd, Casablanca. We evaluated for each patient two validated scores: the Epworth somnolence scale rated from 0 to 24, and the Pittsburgh sleep score rated from 0 to 21 with 7 components. Patients with a psychiatric history or who were followed up for neurological pathologies were excluded.Results:178 patients were included. 60.67% were men with an average age of 36.32 years (14-68 years). 45.01% had axial SpA, 29.77% had psoriatic arthritis, and 25.22% were followed for SpA associated with inflammatory bowel disease. 45% had associated comorbidities: there were 18 diabetics and 34 hypertensive, 16.58% were smokers. Clinically, 85.42% presented a back pain initially on examination, 55% presented a polyarthralgia, and 39.88% an oligoarthritis. 63% had radiological sacroiliitis, and 35.14% had bilateral coxitis. 13.48% had a positive HLA B27 and 58.89% had a positive inflammatory assessment with very high activity indices,with a mean of 4.6. 64.66% of the patients received NSAIDs,of which 11% responded well. 57% were treated with csDMARDs, and 17.86% were treated with biologics. At the time of our study, the mean visual analog scale was 5.84 ± 1.7 out of 10 (2-9). The mean Epworth score was 8.38 ± 5.2 (0-21). 56.1% of patients had no sleep debt, 33.3% had a sleep deficit, and only 10.6% had signs of drowsiness. For the overall Pittsburgh score, the mean was 7.02 ± 3.6 (1-18). The mean of “subjective quality of sleep” was 1.12, “sleep latency” was 1.22, “duration of sleep” was 1.06, “usual sleep efficiency” was 0.74, “Sleep disturbance” of 1.28, “use of a sleep medication” of 0.54, and the average of the component concerning “poor shape during the day” was 1.03 out of 3. The LEQUESNE index went from an average of 6 to 8, which corresponds to an average handicap (P = 0.2) over a period of 3 years. 68% of the patients had an alteration in the quality of sleep, starting on average three years after the onset of symptoms. 11% reported having experiencedanxiety and depressive symptoms, and reported having used antidepressants or anxiolytics in the past 5 years.Conclusion:Our study showed the negative impact of SpA on the duration and overall quality of sleep. The degree of pain as well as functional impairment can cause and worsen sleep disturbances in SpA. We have shown that the Pittsburg score increases significantly with the increase of pain.The Lequesne score and that the Epworth score increase with disease activity[1].References:[1]StolwijkC,vanTubergenA,Castillo-OrtizJD,BoonenA.Prevalenceofextra-articularmanifestationsinpatientswithankylosingspondylitis:asystematicreviewandmeta-analysis.AnnRheumDis2015;74:65—73.Disclosure of Interests:None declared.
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Roelofsen, Paul, Kaspar Jansen et Peter Vink. « A transient thermal sensation equation fit for the modified Stolwijk model ». Intelligent Buildings International, 13 août 2021, 1–14. http://dx.doi.org/10.1080/17508975.2021.1962785.
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Whitmore, Janet. « The Thannhauser Gallery : Marketing Van Gogh edited by Stefan Koldehoff and Chris Stolwijk ». Nineteenth-Century Art Worldwide 17, no 2 (15 octobre 2018). http://dx.doi.org/10.29411/ncaw.2018.17.2.15.
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Ichwan, Moch Nur. « Anton Stolwijk (2021), "Aceh ; Kisah datang dan terusirnya Belanda dan jejak yang ditinggalkan" ». Wacana, Journal of the Humanities of Indonesia 23, no 3 (31 octobre 2022). http://dx.doi.org/10.17510/wacana.v23i3.1008.
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Hoek, Anne-Lot. « Anton Stolwijk, Atjeh. Het verhaal van de bloedigste strijd uit de Nederlandse koloniale geschiedenis ». BMGN - Low Countries Historical Review 132 (28 décembre 2017). http://dx.doi.org/10.18352/bmgn-lchr.10475.
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« H&W-redacteur Lisanne Stolwijk : ‘In de spreekkamer voel ik de behoefte aan houvast’ ». Huisarts en wetenschap 65, no 12 (29 novembre 2022) : 60. http://dx.doi.org/10.1007/s12445-022-2109-3.
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ОРЛОВА, Е. Е., И. Н. ЗУБИК, Ю. Г. ФИЛЬЦЫНА, Х. В. ШАРАФУТДИНОВ et Т. А. АНИСЬКИНА. « THE INFLUENCE OF THE TYPE OF SUPPORT ON THE DECORATIVE QUALITIES OF CLEMATIS VARIETIES (CLEMATIS L.) IN CONTAINER CULTURE ». Естественные и технические науки, no 8(146) (30 septembre 2020). http://dx.doi.org/10.25633/etn.2020.08.05.
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В статье приведена оценка декоративных качеств сортов клематиса при выращивании в контейнерах, изучены сорта: Blue Light , Daniel Deronda; Kakio (Pink champagne); Laura; Multi Blue; Perida; The President; Veronica’s Choice; Pink Flamingo; Stolwik Gold. Также рассмотрены результаты влияния типа опоры на декоративные качества сортов клематиса - White Swan, Rosalyn, Doctor Ruppel, Asao. The article provides an assessment of the decorative qualities of clematis varieties when grown in containers, studied varieties: Blue Light, Daniel Deronda; Kakio (Pink champagne); Laura; Multi Blue; Perida; The president; Veronica’s Choice; Pink flamingo; Stolwik Gold. The results of the influence of the support type on the decorative qualities of clematis varieties - White Swan, Rosalyn, Doctor Ruppel, Asao, are also considered.
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Alexander, Rosemary. « P15 Acupuncture treatment of Costochondritis, a case series ». Rheumatology Advances in Practice 6, Supplement_1 (26 septembre 2022). http://dx.doi.org/10.1093/rap/rkac067.015.
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Abstract Introduction/Background I had been practising acupuncture for 30 years and noticed while working in the rheumatology clinic that costochondritis had a particular response to acupuncture. As this condition is extremely debilitating and often misdiagnosed, a case series of 8 cases is presented, the majority of whom were seen in primary care. Description/Method Costochondritis is characterised by anterior chest pain associated with painful tender costochondral (CC) joints felt on palpation. These mainly affect the 2nd to 5th costochondral junctions, either unilateral or bilateral. Other areas of the anterior and lateral chest wall can also be affected. The pain is often severe and nocturnal, of sudden onset and can be associated with shock, nausea and dyspnoea, causing patients to call for an ambulance. Tietze's syndrome is a rare variant of this, usually affecting younger patients. Patients with persistent chest wall pain were offered acupuncture. Details of age, duration of symptoms, number of treatments and VAS pain scores were recorded day and night, (Table 1) pre and post treatment Patients with thoracic pain were excluded. 0.25*25mm and 0.25*30mm needles were used with silicon tips and a guide tube, to help prevent painful insertion. An infra-red lamp (Bio-lamp) was used + electro-acupuncture (EA) if insufficient improvement after two close treatments, sessions were continued weekly. Acupuncture points used were local tender/trigger points + distal Chinese points P6 and LI4. Other points used were CV 17, GB 34, SI6, GB39 or Sp 6 and St36. An average of 4.7 sessions were needed. Audit of Acupuncture Treatment Table 1 Six patients took daily analgesia which was rapidly reduced to nil. All completed their treatment until their pain stabilised. There were no adverse events. Average improvement in the day was 89% and night 85%. Recurrences of pain improved by 11% in the day and 72% at night. The attacks of severe chest pain and dyspnoea stopped, abating anxiety. Discussion/Results Costochondritis is a highly debilitating condition and I had noticed that acupuncture could be a dramatic treatment for this[i]. It can affect up to a third of patients attending emergency departments with atypical chest pain[ii] and 1-3% of patients in primary care[iii]. It seems to be a missed diagnosis by Accident and Emergency (A&E) doctors and GPs, perhaps because the chest wall was not carefully palpated. One patient had ankylosing spondylitis (AS) and another had systemic lupus erythematosus but attributed her pain to prolonged laughter. Five patients attended cardiology clinics including one who had a coronary angiogram. Another had tests for upper abdominal pain which also were normal. All the patients were female although quoted F:M ratio is 7:3 Differential diagnoses include: acute coronary syndromes, lung problems, trauma, upper gastroenterology pathology or neoplasia Pathogenesis is unclear but the onset can be acute and follow: Respiratory tract infection Extreme sneezing, coughing or laughter Chest wall trauma Micro trauma from costovertebral dysfunction Fibromyalgia Inflammation from inflammatory joint disease. [i] Alexander R; White A. Acupuncture in a Rheumatology Clinic. Acupuncture in Medicine; Dec 2000 vol.18 (no.2): 100-103 [ii] Disla E; Rhim HR; Reddy A; Karten I; Taranta A. A prospective analysis in an emergency department setting. Arch Intern Med. 1994; 154(21):2466-2469 [iii] Ayloo A; Cvengros T; Marella S. Evaluation and treatment of musculoskeletal chest pain. Prim Care (Review) Dec 2013 40(4): 863-87 Key learning points/Conclusion Normal management of costochondritis includes analgesia, physiotherapy, steroid injections and occasionally surgery[i]. 30% can have protracted pain. There are isolated reports of acupuncture for this condition, integrated with conventional medicine[ii] [iii]. Acupuncture also has been used for myofascial trigger points including costochondritis[iv]. Acupuncture is now an accepted modality of pain management and in 2021 was recommended in NICE guidelines for the treatment of Chronic Primary Pain alongside exercise programmes and CBT ahead of analgesic medication[v]. It has also been recommended in the management of low back pain in patients aged 60 years and over as a non-drug treatment[vi]. This paper highlights the fact that acupuncture appears to be a safe effective treatment for costochondritis, with further research and more access needed for this therapeutic modality. Increased awareness of this condition would make complex invasive investigations less necessary. [i] Gologorsky R; Hornik B; Velotta J. Surgical Management of Medically Refractory Tietze's Syndrome. Annals of Thoracic Surgery; Dec 2017; vol. 104 (no. 6) [ii] Jonkman FAM.; Jonkman-Buidin M.L; Stolwijk P.W.J. Surprise after successful treatment of a patient with noncardiac chest pain using acupuncture. Medical Acupuncture; Feb 2015; vol.27(no 1):83-90 [iii] Lin, Katerina; Tung, Cynthia. Integrating Acupuncture for the Management of Costochondritis in Adolescents. Medical Acupuncture; Oct 2017; vol.29(no 5): 327-330 [iv] Baldry P. Cardiac and non-cardiac chest wall pain. Acupuncture in Medicine;1997; vol.15(no.2): 42-45 [v] NICE guideline; Chronic Pain (primary and secondary) in over 16s (NG 193 April 2021) [vi] Traeger A; Underwood M;Ivers R; Buchbinder R. Low back pain in people aged 60 years and over. BMJ 2022 vol. 376: e066928