Articles de revues sur le sujet « (stamp, New York) (donor) »
Pour voir les autres types de publications sur ce sujet consultez le lien suivant : (stamp, New York) (donor).
Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres
Consultez les 50 meilleurs articles de revues pour votre recherche sur le sujet « (stamp, New York) (donor) ».
À côté de chaque source dans la liste de références il y a un bouton « Ajouter à la bibliographie ». Cliquez sur ce bouton, et nous générerons automatiquement la référence bibliographique pour la source choisie selon votre style de citation préféré : APA, MLA, Harvard, Vancouver, Chicago, etc.
Vous pouvez aussi télécharger le texte intégral de la publication scolaire au format pdf et consulter son résumé en ligne lorsque ces informations sont inclues dans les métadonnées.
Parcourez les articles de revues sur diverses disciplines et organisez correctement votre bibliographie.
1
Mountford, Peter. « Prolific Donor ». Ploughshares 50, no 2 (juin 2024) : 148–64. http://dx.doi.org/10.1353/plo.2024.a932301.
Texte intégralRésumé :
Abstract: The Summer 2024 Issue. Ploughshares is an award-winning journal of new writing. Since 1971, Ploughshares has discovered and cultivated the freshest voices in contemporary American literature, and now provides readers with thoughtful and entertaining literature in a variety of formats. Find out why the New York Times named Ploughshares “the Triton among minnows.” The Summer 2024 Issue, guest-edited by Rebecca Makkai, features prose by Dur e Aziz Amna, Ramona Ausubel, Peter Mountford, Khaddafina Mbabazi, DK Nnuro, and more.
2
Kurti, Marin, Klaus von Lampe, Yi He, Cristine Delnevo et Da Qin. « Innovations in counterfeiting tax stamps : a study of ultraviolet watermarks in a sample of discarded New York City packs ». Tobacco Control 28, no 4 (3 septembre 2018) : 469–71. http://dx.doi.org/10.1136/tobaccocontrol-2018-054501.
Texte intégralRésumé :
ObjectiveDocument the use of ultraviolet watermark in counterfeit joint New York City/New York State cigarette tax stamps to assess the scale at which distributors of illegal cigarettes adapt to measures protecting the integrity of the system of tobacco tax collection.MethodsIn 2016, we collected 2357 empty discarded cigarette packs along a stratified random sample of block groups in New York City (n=114) and analysed 449 joint New York City/New York State tax stamps using long wave ultraviolet irradiation, light microscopy and taggant testers developed by the tax stamp manufacturer, Meyercord Revenue, to determine whether the tax stamps were counterfeit and how they differed from their genuine equivalent.Findings23% (n=102) of the joint NYC/NYS tax stamps examined were counterfeit. Subsequent investigation revealed that almost two-thirds (n=58) of the counterfeit sample bore ultraviolet watermark that closely resembled genuine tax stamps in terms of fluorescence, watermark colour and wording. However, microscopic findings revealed that counterfeit tax stamps mismatched the genuine ultraviolet watermark in regards to font style and word orientation.ConclusionCounterfeiters are using ultraviolet watermarks which makes it difficult to differentiate counterfeit joint New York City/New York State tax stamps from their genuine equivalent when UV irradiation is used as the sole screening tool. Innovations in counterfeiting technology may be the result of fluorescent ink being available for purchase in the mainstream market. Independent monitoring of trends in the illicit market for tobacco products is advised to keep apace of counterfeiting methods.
3
Silver, Diana, Margaret M. Giorgio, Jin Yung Bae, Geronimo Jimenez et James Macinko. « Over-the-counter sales of out-of-state and counterfeit tax stamp cigarettes in New York City : Table 1 ». Tobacco Control 25, no 5 (27 août 2015) : 584–86. http://dx.doi.org/10.1136/tobaccocontrol-2015-052355.
Texte intégral
4
Shaul Bar Nissim, Hanna. « “New Diaspora Philanthropy” ? The Philanthropy of the UJA-Federation of New York Toward Israel ». Nonprofit and Voluntary Sector Quarterly 48, no 4 (15 février 2019) : 839–58. http://dx.doi.org/10.1177/0899764019828048.
Texte intégralRésumé :
This article explores the ways in which new philanthropic practices and grant-making patterns changed Jewish diaspora philanthropy. Based on an in-depth exploration of the philanthropy of the UJA-Federation of New York toward Israel, the article posits the development of a new Jewish diaspora philanthropy and outlines its characteristics and expressions. Findings suggest new missions, goals, activities, and philanthropic practices in Israel and point to a shift in the extent of donor engagement in decision-making. The article offers a broader discussion on the meanings and implications for the integration of new institutional environments, in the form of new philanthropic practices, to the organizational field of Jewish philanthropy, while highlighting the dilemmas generated in the process for the Federation and for recipient organizations.
5
Feeley, Thomas Hugh, Ashley E. Anker, Melanie Evans et Tobias Reynolds-Tylus. « A Department of Motor Vehicle–Based Intervention to Promote Organ Donor Registrations in New York State ». Progress in Transplantation 27, no 3 (4 juillet 2017) : 273–80. http://dx.doi.org/10.1177/1526924817715471.
Texte intégralRésumé :
Context: Examination of efficacy of motor vehicle representative educational training and dissemination of promotional materials as a means to promote organ donation enrollments in New York State. Objective: To increase the number of New York State residents who consent to donation through the department of motor vehicle transactions during project period. Setting: County-run motor vehicle offices across New York State. Participants: Customers who present to New York Department of Motor Vehicle offices and the representative who work at designated bureaus. Interventions: point-of-decision materials including promotional posters, brochures, website, and the motor vehicle representative training sessions. Main Outcome Measures: Reasons for enrollment decision, knowledge/experience with donation, monthly consent rates, enrollment in state organ, and tissue registry. Results: Customers who elected not to register reported no reason or uncertainty surrounding enrollment. The representatives reported experience with donation, discussion with customers, and need for additional education on organ donation. Enrollment cards were mailed to 799 project staff; counties where offices participated in intervention did not indicate significantly higher monthly enrollments when comparing pre- to postenrollment rates. Conclusions: Use of point-of-decision materials and enrollment cards proved inexpensive method to register customers with a 3.6% return rate. Customers report low (27%) enrollment rate and reticence to consent to donation. Educational training sessions with representatives did not yield significant enrollment increases when evaluating data at county-level enrollment.
6
Jensen, Anja. « Searching for meaningful aftermaths : donor family experiences and expressions in New York and Denmark ». Sites : a journal of social anthropology and cultural studies 8, no 1 (2011) : 129–48. http://dx.doi.org/10.11157/sites-vol8iss1id175.
Texte intégral
7
Wagner, JE, J. Rosenthal, R. Sweetman, XO Shu, SM Davies, NK Ramsay, PB McGlave, L. Sender et MS Cairo. « Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors : analysis of engraftment and acute graft-versus-host disease ». Blood 88, no 3 (1 août 1996) : 795–802. http://dx.doi.org/10.1182/blood.v88.3.795.795.
Texte intégralRésumé :
Abstract To reduce the morbidity and mortality associated with unrelated donor bone marrow (BM) transplantation and potentially extend the pool of suitable donors, cryopreserved unrelated donor umbilical cord blood was considered as an alternate source of hematopoietic stem cells for transplantation. Patients with leukemia, BM failure syndrome, or inborn error of metabolism were eligible for a phase I clinical trial designed to estimate the risk of graft failure and severe acute graft-versus- host disease after transplantation of umbilical cord blood from unrelated donors. As of December 21, 1995, unrelated donor umbilical cord blood was used to reconstitute hematopoiesis in eighteen patients aged 0.1 to 21.3 years weighing 3.3 to 78.8 kg with acquired or congenital lympho-hematopoietic disorders or metabolic disease. Patients received either HLA-matched (n = 7) or HLA-1 to 3 antigen disparate (n = 11) grafts collected and evaluated by the New York Blood Center (New York, NY). The probability of engraftment after unrelated donor umbilical cord blood transplantation was 100% with no patient having late graft failure to date. The probability of grade III-IV acute graft-versus-host disease at 100 days was 11%. With a median follow-up of 6 months (range, 1.6 to 17 months); the probability of survival at 6 months is 65% in this high risk patient population. We conclude that cryopreserved umbilical cord blood from HLA-matched and mismatched unrelated donors is a sufficient source of transplantable hematopoietic stem cells with high probability of donor derived engraftment and low risk of refractory severe acute graft-versus-host disease. Limitations with regard to recipient size and degree of donor HLA disparity remain to be determined.
8
Wagner, JE, J. Rosenthal, R. Sweetman, XO Shu, SM Davies, NK Ramsay, PB McGlave, L. Sender et MS Cairo. « Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors : analysis of engraftment and acute graft-versus-host disease ». Blood 88, no 3 (1 août 1996) : 795–802. http://dx.doi.org/10.1182/blood.v88.3.795.bloodjournal883795.
Texte intégralRésumé :
To reduce the morbidity and mortality associated with unrelated donor bone marrow (BM) transplantation and potentially extend the pool of suitable donors, cryopreserved unrelated donor umbilical cord blood was considered as an alternate source of hematopoietic stem cells for transplantation. Patients with leukemia, BM failure syndrome, or inborn error of metabolism were eligible for a phase I clinical trial designed to estimate the risk of graft failure and severe acute graft-versus- host disease after transplantation of umbilical cord blood from unrelated donors. As of December 21, 1995, unrelated donor umbilical cord blood was used to reconstitute hematopoiesis in eighteen patients aged 0.1 to 21.3 years weighing 3.3 to 78.8 kg with acquired or congenital lympho-hematopoietic disorders or metabolic disease. Patients received either HLA-matched (n = 7) or HLA-1 to 3 antigen disparate (n = 11) grafts collected and evaluated by the New York Blood Center (New York, NY). The probability of engraftment after unrelated donor umbilical cord blood transplantation was 100% with no patient having late graft failure to date. The probability of grade III-IV acute graft-versus-host disease at 100 days was 11%. With a median follow-up of 6 months (range, 1.6 to 17 months); the probability of survival at 6 months is 65% in this high risk patient population. We conclude that cryopreserved umbilical cord blood from HLA-matched and mismatched unrelated donors is a sufficient source of transplantable hematopoietic stem cells with high probability of donor derived engraftment and low risk of refractory severe acute graft-versus-host disease. Limitations with regard to recipient size and degree of donor HLA disparity remain to be determined.
9
Green, Donald P., Jonathan S. Krasno, Costas Panagopoulos, Benjamin Farrer et Michael Schwam-Baird. « Encouraging Small Donor Contributions : A Field Experiment Testing the Effects of Nonpartisan Messages ». Journal of Experimental Political Science 2, no 2 (2015) : 183–91. http://dx.doi.org/10.1017/xps.2015.1.
Texte intégralRésumé :
AbstractWe report the results of a field experiment conducted in New York City during the 2013 election cycle, examining the impact ofnonpartisanmessages on donations from small contributors. Using information from voter registration and campaign finance records, we built a forecasting model to identify voters with an above-average probability of donating. A random sample of these voters received one of four messages asking them to donate to a candidate of their choice. Half of these treatments reminded voters that New York City's campaign finance program matches small donations with public funds. Candidates’ financial disclosures to the city's Campaign Finance Board reveal that only the message mentioning policy (in generic terms) increased donations. Surprisingly, reminding voters that matching funds multiplied the value of their contribution had no effect. Our experiment sheds light on the motivations of donors and represents the first attempt to assess nonpartisan appeals to contribute.
10
Burr, Andrew T., Nicholas G. Csikesz, Earl Gonzales, Jennifer F. Tseng, Reza F. Saidi, Adel Bozorgzadeh et Shimul A. Shah. « Comparison of Right Lobe Donor Hepatectomy with Elective Right Hepatectomy for Other Causes in New York ». Digestive Diseases and Sciences 56, no 6 (27 novembre 2010) : 1869–75. http://dx.doi.org/10.1007/s10620-010-1489-6.
Texte intégral
11
Malbin, Michael J., et Michael Parrott. « Small Donor Empowerment Depends on the Details : Comparing Matching Fund Programs in New York and Los Angeles ». Forum 15, no 2 (26 juillet 2017) : 219–50. http://dx.doi.org/10.1515/for-2017-0015.
Texte intégralRésumé :
Abstract Political campaigns have long been financed by people with well above average incomes, but the balance has tilted dramatically since the Supreme Court’s 2010 decision in Citizens United v. FEC. A number of jurisdictions have been looking to rebalance the incentives through new (or updated) public financing programs. Much of the discussion about their potential effects, however, has been sweepingly generic. But we know that these programs do differ from each other and have good reason to expect that “success” or “failure” will depend both on their goals and the programs’ details. This article focuses on one type of program that has become a model in recent years. Until recently New York City was the only jurisdiction with a multiple matching system explicitly designed to increase the role of small donors.Previous studies noted apparent successes, but it has been difficult to feel comfortable with only one jurisdiction to test. After Los Angeles revised its system in 2013, serious comparisons became possible. This article finds that New York City’s campaign finance matching fund program increased the number, proportional role, and diversity of small donors in city council elections but that the Los Angeles program was substantially less effective. The findings were confirmed through a difference-in-differences procedure that tested each city council over time against state legislative districts representing the same geographical space. A series of explanations relating to the programs’ details were tested, leading us to conclude that the policy details were affecting the results. The results were also different in both cities for mayoral and city council candidates. This suggests alterations may be needed if one were to consider the model for offices with larger constituencies, such as Governor or the US Congress. Finally, the article concludes with a discussion of major arguments for and against increasing small donor participation as a goal for public policy.
12
Kessler, Debra A., Patricia A. Shi, Scott T. Avecilla et Beth H. Shaz. « Results of lookback for Chagas disease since the inception of donor screening at New York Blood Center ». Transfusion 53, no 5 (15 août 2012) : 1083–87. http://dx.doi.org/10.1111/j.1537-2995.2012.03856.x.
Texte intégral
13
Agarwal, Nikhil, Itai Ashlagi, Michael A. Rees, Paulo Somaini et Daniel Waldinger. « Equilibrium Allocations Under Alternative Waitlist Designs : Evidence From Deceased Donor Kidneys ». Econometrica 89, no 1 (2021) : 37–76. http://dx.doi.org/10.3982/ecta17017.
Texte intégralRésumé :
Waitlists are often used to ration scarce resources, but the trade‐offs in designing these mechanisms depend on agents' preferences. We study equilibrium allocations under alternative designs for the deceased donor kidney waitlist. We model the decision to accept an organ or wait for a preferable one as an optimal stopping problem and estimate preferences using administrative data from the New York City area. Our estimates show that while some kidney types are desirable for all patients, there is substantial match‐specific heterogeneity in values. We then develop methods to evaluate alternative mechanisms, comparing their effects on patient welfare to an equivalent change in donor supply. Past reforms to the kidney waitlist primarily resulted in redistribution, with similar welfare and organ discard rates to the benchmark first‐come, first‐served mechanism. These mechanisms and other commonly studied theoretical benchmarks remain far from optimal. We design a mechanism that increases patient welfare by the equivalent of an 18.2% increase in donor supply.
14
Rudow, Dianne LaPointe, et Robert S. Brown. « Role of the Independent Donor Advocacy Team in Ethical Decision Making ». Progress in Transplantation 15, no 3 (septembre 2005) : 298–302. http://dx.doi.org/10.1177/152692480501500317.
Texte intégralRésumé :
Adult living donor liver transplantation has developed as a direct result of the critical shortage of deceased donors. Recent regulations passed by New York State require transplant programs to appoint an Independent Donor Advocacy Team to evaluate, educate, and consent to all potential living liver donors. Ethical issues surround the composition of the team, who appoints them, and the role the team plays in the process. Critics of living liver donation have questioned issues surrounding motivation and the ability of donors to provide true informed consent during a time of family crisis. This article will address issues surrounding the controversies and discuss how using the team can effectively evaluate and educate potential living liver donors and improve practice to ensure safety of living donors.
15
Zubair, Hassan Bin, Dur-e.-Afshan Babar et Muhammad Maaz. « Analyzing Ambivalence and Hybridized Individualistic Western Cultural Values in Mohsin Hamid’s Moth Smoke ». Winter 2023 3, no 1 (31 mars 2023) : 799–808. http://dx.doi.org/10.54183/jssr.v3i1.202.
Texte intégralRésumé :
This research explores postcolonial issues like ambivalence, cultural hybridity, mimicry, and identity crisis in Mohsin Hamid’s novel Moth Smoke. The novel presents the picture of Pakistani society surrounded by the presence of western values, cultural rifts and obsessions of materiality, and a weakening bond between the community and moral codes. Bhabha’s theory provides grounds to analyze the selected text. The wealthy characters of the novel, like Ozi and Mumtaz, are pursuing individualistic lifestyles affected by their touch with New York during their studies, while some Pakistani characters, like the drug dealer, Murad, are pursuing English as a basic language of communication only to hide their reality of low origin and stamp their authority and control over other. Ambivalence, hybridity, and mimicry of these characters are analyzed in this research. The hybridized individualistic western values lead Mumtaz to become an infidel to his husband and have extramarital affairs with Daru going against the cultural values of the Pakistani society with rigid patriarchal and sexual control over women. The space of cultural hybridity paves the way for mimicry in most of the instances and also leads to the downfall of Daru, the economically poor class friend of Ozi.
16
Al-Sarraf, A., K. Sachs-Barrable, J. Hill, K. Wasan et J. Frohlich. « CETP IN RARE DYSLIPIDEMIAS ». Clinical & ; Investigative Medicine 32, no 6S (15 décembre 2009) : 3. http://dx.doi.org/10.25011/cim.v32i6s.11136.
Texte intégralRésumé :
Objective: To determines CETP mass and activity in rare disorders of HDL metabolism. Methods: Patients: Fasting plasma samples were obtained from two individuals with TD and from patients with LCAT deficiency, analphalipoproteinemia, Hepatic lipase deficiency (HL), vasculitis, and hypoalphalipoprteinemia. Their clinical and laboratory findings have been previously reported. Assay: CETP activity was measured using commercial CETP Fluorescence kit (Roar Biomedical Inc., New York, NY). The kit includes donor (without apoA-I) and acceptor lipoprotein particles. Incubation of donor and acceptor with a CETP source results in the CETP mediated transfer of fluorescent neutral lipid from donor to acceptor, rate of which is determined by the increase in fluorescence intensity as the fluorescent neutral lipid is removed from the donor to the acceptor. The amount of fluorescent substrate transferred was expressed as pmoles of fluorescent substrate transferred within 3 hours. CETP concentration was measured by ELISA using specific rabbit antibody against human CETP. Results: While CETP mass correlated with serum HDL-C levels, the activity decreased in patients with LCAT deficiency, FED, HL deficiency and vascultis, but increased in TD. We speculate that the composition of HDL particles in these disorders differs and results in the different CE transfer rates. Conclusion: CETP mass correlates with the HDL-C concentration but the activity differ widely among the patients with rare disorders of HDL metabolism, probably due to the changes in HDL quality.
17
Priest, Greg. « Marco Solinas. From Aristotle’s Teleology to Darwin’s Genealogy : The Stamp of Inutility. Translated by James Douglas. x + 182 pp., bibl., index. New York : Palgrave Macmillan, 2015. $95 (cloth). » Isis 108, no 4 (2 décembre 2017) : 869–70. http://dx.doi.org/10.1086/695357.
Texte intégral
18
Duan, Sunpeng, Yuedong Wang, Peter Kotanko et Hanjie Zhang. « Network analysis of spread of SARS-CoV-2 within dialysis clinics : A multi-center network analysis ». PLOS ONE 19, no 3 (8 mars 2024) : e0299855. http://dx.doi.org/10.1371/journal.pone.0299855.
Texte intégralRésumé :
Background In-center hemodialysis entails repeated interactions between patients and clinic staff, potentially facilitating the spread of COVID-19. We examined if in-center hemodialysis is associated with the spread of SARS-CoV-2 between patients. Methods Our retrospective analysis comprised all patients receiving hemodialysis in four New York City clinics between March 12th, 2020, and August 31st, 2022. Treatment-level clinic ID, dialysis shift, dialysis machine station, and date of COVID-19 diagnosis by RT-PCR were documented. To estimate the donor-to-potential recipient exposure (“donor” being the COVID-19 positive patient denoted as “COV-Pos”; “potential recipient” being other susceptible patients in the same shift), we obtained the spatial coordinates of each dialysis station, calculated the Euclidean distances between stations and weighted the exposure by proximity between them. For each donor, we estimated the donor-to-potential recipient exposure of all potential recipients dialyzed in the same shift and accumulated the exposure over time within the ‘COV-Pos infectious period’ as cumulative exposures. The ‘COV-Pos infectious period’ started 5 days before COVID-19 diagnosis date. We deployed network analysis to assess these interactions and summarized the donor-to-potential recipient exposure in 193 network diagrams. We fitted mixed effects logistic regression models to test whether more donor-to-potential recipient exposure conferred a higher risk of SARS-CoV-2 infection. Results Out of 978 patients, 193 (19.7%) tested positive for COVID-19 and had contact with other patients during the COV-Pos infectious period. Network diagrams showed no evidence that more exposed patients would have had a higher chance of infection. This finding was corroborated by logistic mixed effect regression (donor-to-potential recipient exposure OR: 0.63; 95% CI 0.32 to 1.17, p = 0.163). Separate analyses according to vaccination led to materially identical results. Conclusions Transmission of SARS-CoV-2 between in-center hemodialysis patients is unlikely. This finding supports the effectiveness of non-pharmaceutical interventions, such as universal masking and other procedures to control spread of COVID-19.
19
PARISH, PETER J. « The Will to Fight and the Will to Write : Some Recent Books on the American Civil War ». Journal of American Studies 32, no 2 (août 1998) : 295–305. http://dx.doi.org/10.1017/s0021875898005908.
Texte intégralRésumé :
David J. Eicher, The Civil War in Books: An Analytical Bibliography (Urbana: University of Illinois Press, 1997, $39.95). Pp. 432. ISBN 0 252 02273 4.Gary W. Gallagher, The Confederate War (Cambridge, Mass. and London: Harvard University Press, 1997, $24.95). Pp. 222. ISBN 0 674 16055 x.Judith N. McArthur and Orville Vernon Burton (editors), “A Gentleman and an Officer”: A Military and Social History of James B. Griffin's Civil War (New York: Oxford University Press, 1996, $30.00). Pp. 382. ISBN 0 19 509311 9.A. K. McClure, Abraham Lincoln and Men of War Times: Some Personal Recollections of War and Politics during the Lincoln Administration (Bison Books edition, with introduction by James A. Rawley; Lincoln: University of Nebraska Press, 1996, £18.95). Pp. 496. ISBN 0 8032 8228 1.James M. McPherson, For Cause and Comrades: Why Men Fought in the Civil War (New York: Oxford University Press, 1997, £20.00). Pp. 256. ISBN 0 19 509023 3.John Michael Priest, Before Antietam: The Battle for South Mountain (New York: Oxford University Press, 1992; pbk 1996, £15.99). Pp. 455. ISBN 0 19 510712 8.Jack D. Welsh, Medical Histories of Union Generals (Kent, OH: Kent State University Press, 1996). Pp. 442. ISBN 0 87338 552 7.Donald Yacovone (editor), A Voice of Thunder: The Civil War Letters of George E. Stephens (Urbana: University of Illinois Press, 1997, $26.95). Pp. 372. ISBN 0 252 02245 9.Like Ol' Man River, Civil War historiography just keeps rolling along. It changes course occasionally, leaving behind bayous of stagnant argument, while it carves out new lines of inquiry and debate. The books under review here follow the meandering course of this great river of historical writing. There are two scholarly editions of the writings of Civil War soldiers, one northern one southern, one black one white. There are two reference works, each of them bearing the rather idiosyncratic stamp of its editor. The immensely detailed battlefield narrative, as exemplified by John Michael Priest's book on South Mountain, adheres to a tradition of Civil War historical writing that resists changing historiographical fashions, and continues to appeal to a readership which knows the kind of military history it likes, and simply wants still more of it. Another honoured tradition in Civil War literature is the reprint of a “classic” written by someone who lived through the conflict, and Alexander McClure has good claims to inclusion in this category. Finally, there are two quite brief books by two heavyweight historians, James McPherson and Gary Gallagher, who address some of the perennial Civil War issues, such as why did men fight and go on fighting, and which is more in need of explanation: why did the Confederacy lose, or how did it manage to fight for so long?
20
Graves, Maya C., Sapna A. Mehta, Bonnie E. Lonze et Nicole M. Ali. « Evaluation and Transplantation of a SARS-CoV-2 Seropositive Kidney Candidate ». Case Reports in Nephrology 2021 (8 mars 2021) : 1–5. http://dx.doi.org/10.1155/2021/6613023.
Texte intégralRésumé :
The COVID-19 pandemic affected transplant center activity in areas with high number of cases such as New York City and prompted reevaluation of patients awaiting organ transplant diagnosed with SARS-CoV-2 infection. To resume safe transplantation at our center, we found it necessary to (1) identify transplant candidates with possible exposure to or history of COVID-19 infection, (2) outline a clinical and laboratory assessment to determine adequate clinical recovery from COVID-19 for transplantation, and (3) determine whether the possibility of perioperative COVID-19 transmission from the patient to staff would pose unacceptable risk. Here, we describe our center’s approach to proceeding with transplantation in a SARS-CoV-2 seropositive living donor kidney transplant recipient and describe early posttransplant outcomes.
21
Segal, Nancy L. « Twins Reared Apart : Zygotic Division After Artificial Insemination/Twin Research Reviews : Selective Resuscitation of Premature Twins ; Scientist Jailed for Editing Twins’ Genes ; Sexual Arousal Patterns in MZ Twins Discordant for Sexual Orientation ; MZ Twins With Jejuno-Ileal Atresia/Media Reports : Twin Girls’ Search for a Bone Marrow Donor ; Puppy with a Possible Parasitic Twin ; Twins in Silicon Valley ; Surgical Separation of Craniopagus Twins ; Twin-Based New Yorker Magazine Cartoon ; Twin Tragedies ». Twin Research and Human Genetics 23, no 2 (avril 2020) : 139–43. http://dx.doi.org/10.1017/thg.2020.11.
Texte intégralRésumé :
AbstractThis article opens with the brief life histories of reared-apart monozygotic (MZ) male twins. A New York City program that helped childless couples conceive via artificial insemination from the 1930s to the 1950s is examined as it related to these twins. The frequency with which pregnancies following assisted reproductive technology resulted in MZ twin pairs is also provided. Next, summaries of twin research concerning selective resuscitation, gene editing, sexual arousal and jejuno-ileal atresia are presented. The article ends with media reports of twin girls’ efforts to find a bone marrow donor for their father, possible parasitic twinning in a puppy, identical female twins’ business venture, the surgical separation of craniopagus twins, a twin-themed magazine cartoon and tragic events involving identical male twins.
22
Scholtz, Sibylle Katharina, Gerd Uwe Auffarth, Olaf Hellwinkel, Daniel Kampik, Philip Christian Maier, Berthold Seitz, Thomas Wegner, Frank Krogmann, Katja Rosenbaum et Gerd Geerling. « The Development and Status of Eye Banking with Special Focus on the Commitment of LIONS Clubs ». Klinische Monatsblätter für Augenheilkunde 238, no 06 (17 mars 2021) : 656–62. http://dx.doi.org/10.1055/a-1263-9979.
Texte intégralRésumé :
Abstract Background Ever since the first successful keratoplasty in 1905, there has been a need to store corneas for transplantation. R. Townley Paton founded the first eye bank in New York in 1944. With Helen Kellerʼs call in 1925 for LIONS to “constitute themselves Knights of the Blind in the crusade against darkness”, LIONS Clubs International has become involved in the establishment of eye banks worldwide. This paper presents the development of eye banking in general and with special attention to the support offered by LIONS Clubs. Methods Selective literature search through PubMed, Google Scholar and Google in close cooperation with the LIONS Eye Banks already established in Germany, LIONS Clubs International (USA) and the Julius Hirschberg Society (Austria). Analysis focused on the founding processes of 6 German eye banks and their current services. Results Filatov was the first to keep donor eyes in a cool, moist container for a few days. In 1973, Summerlin et al described the technique of organ culture for donor corneas, and McCarey & Kaufman described a liquid storage medium in 1974. LIONS Clubs International and their organisational structure first supported an eye bank in the US in 1952, outside America in Hong Kong in 1962 and in Germany in 1969. Funding is provided across all levels of LIONS as network support and material resources. In general, staff funding is not provided. Of the 88 eye banks operating worldwide today, 44 are called LIONS Eye Banks. 6 of the current 26 eye banks in Germany are operating under LIONS sponsorship and run by departments of ophthalmology at university medical centres. Although the number of transplants has increased in recent years due to new surgical techniques, the number of patients waiting for donor tissue is also growing as a result of the broadening indication. Conclusions Even today, the availability of donor corneas limits patient care. Eye banks help to meet the need for donor corneas. However, the techniques and technical equipment of eye banks must undergo continuous improvement. The local, national and international network of LIONS Clubs can assist in establishing these in order to facilitate legal requirements and structural developments. This support frequently lasts for many years, often triggers additional public commitment and is thus also a supporting element for the future development of eye banking in Germany.
23
Gonick, Lev S. « Donor Aid—The Determinants of Development Allocations to Third World Countries : A Comparative AnalysisLouis M. Imbeau New York : Peter Lang, 1989, pp. xv, 228 ». Canadian Journal of Political Science 24, no 1 (mars 1991) : 173–74. http://dx.doi.org/10.1017/s0008423900013615.
Texte intégral
24
Emmett, Michael. « Book Review The Measurement of Metabolic Bone Disease (Measurements in Medicine Series. Vol. 1.) Edited by F.I. Tovey and T.C.B. Stamp. 152 pp., illustrated. New York, parthenon, 1995. $58. 1-85070-465-1 ». New England Journal of Medicine 334, no 12 (21 mars 1996) : 805–6. http://dx.doi.org/10.1056/nejm199603213341222.
Texte intégral
25
Humaeroah, Humaeroah. « Psychological Approach On Sacrifice Conflict Of Anna’s Characters In The Novel “My Sister’s Keeper” ». Ganaya : Jurnal Ilmu Sosial dan Humaniora 4, no 2 (10 septembre 2021) : 374–84. http://dx.doi.org/10.37329/ganaya.v4i2.1321.
Texte intégralRésumé :
My Sister’s Keeper is a novel written by a New York Times Best Selling author, Jodi Picoult. The content of the novel tells the journey of a young girl making a sacrifice for her sister. This research aims to analyze the psychology of Anna doing a sacrifice for her sister. The type of this research is qualitative. The emerging conflict in main actors was analyzed using content analysis emphasizing on psychological approach. After reading and classifying My Sister’s Keeper Novel intensively, this study found the sacrifice conflict appeared in the novel. Based on the analysis, the novel shows internal and external conflict. Internal conflict (man vs self) of main character is a psychological conflict of Anna’s character about the sacrifice by doing donor of stem cell given to her sister and external conflict (man vs man) comes from her family.
26
Jin, Daniel K., Daniel J. Nesbitt, Jenny Yang, Haidee Chen, Julie Horowitz, Marcus Jones, Rianna Vandergaast et al. « Seroprevalence of anti-SARS-CoV-2 antibodies in a cohort of New York City metro blood donors using multiple SARS-CoV-2 serological assays : Implications for controlling the epidemic and “Reopening” ». PLOS ONE 16, no 4 (28 avril 2021) : e0250319. http://dx.doi.org/10.1371/journal.pone.0250319.
Texte intégralRésumé :
Projections of the stage of the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pandemic and local, regional and national public health policies to limit coronavirus spread as well as “reopen” cities and states, are best informed by serum neutralizing antibody titers measured by reproducible, high throughput, and statically credible antibody (Ab) assays. To date, a myriad of Ab tests, both available and FDA authorized for emergency, has led to confusion rather than insight per se. The present study reports the results of a rapid, point-in-time 1,000-person cohort study using serial blood donors in the New York City metropolitan area (NYC) using multiple serological tests, including enzyme-linked immunosorbent assays (ELISAs) and high throughput serological assays (HTSAs). These were then tested and associated with assays for neutralizing Ab (NAb). Of the 1,000 NYC blood donor samples in late June and early July 2020, 12.1% and 10.9% were seropositive using the Ortho Total Ig and the Abbott IgG HTSA assays, respectively. These serological assays correlated with neutralization activity specific to SARS-CoV-2. The data reported herein suggest that seroconversion in this population occurred in approximately 1 in 8 blood donors from the beginning of the pandemic in NYC (considered March 1, 2020). These findings deviate with an earlier seroprevalence study in NYC showing 13.7% positivity. Collectively however, these data demonstrate that a low number of individuals have serologic evidence of infection during this “first wave” and suggest that the notion of “herd immunity” at rates of ~60% or higher are not near. Furthermore, the data presented herein show that the nature of the Ab-based immunity is not invariably associated with the development of NAb. While the blood donor population may not mimic precisely the NYC population as a whole, rapid assessment of seroprevalence in this cohort and serial reassessment could aid public health decision making.
27
Devine, T. L., M. L. Looper, J. H. Pryor, E. Kara, M. C. Maurel, J. Decourtye, P. P. Baldauf, K. H. Jurney et C. R. Looney. « 98 COMMERCIAL APPLICATION OF A NEW COW-SIDE LH ASSAY FOR DETERMINING OPTIMUM AI INTERVALS IN SUPEROVULATED BEEF DONORS IN THE USA : A PRELIMINARY STUDY ». Reproduction, Fertility and Development 26, no 1 (2014) : 163. http://dx.doi.org/10.1071/rdv26n1ab98.
Texte intégralRésumé :
Successful superovulation and embryo collection require donors to be managed for precise insemination intervals. At times, determinations of these intervals can become difficult because of oestrus detection subjectivity. The objective of this study was to determine the feasibility of performing a rapid cow-side LH assay (Predi′Bov®, ReproPharm, Nouzilly, France) on superovulated donors with emphasis on determining how to use the results in a commercial program to time inseminations. This study was conducted at Ovagenix (Bryan, TX, USA) on 24 superovulated donors. On Day 0 cows received an intravaginal progesterone-releasing device (CIDR®, Pfizer Animal Health, New York, NY, USA) and were administered 25 mg of progesterone and 2.5 mg of oestradiol 17β intramuscularly (IM, 2 mL). Superstimulation was induced using 150–300 mg of Folltropin-V® (FSH, Bioniche Animal Health Inc., ON, Canada) administered with 7 injections at 12-h intervals in decreasing dosages (Day 4–7). On Day 6, two doses of Estrumate® (equaling 1 mg, Intervet Inc., Merck Animal Health, Summit, NJ, USA) were given IM, concurrently with FSH injections 5 and 6 with CIDR removal on Day 7 (a.m.). HeatWatch® transmitters (Cow Chips LLC, Denver, CO, USA) were applied to donors on Day 7 to determine onset of standing oestrus. Blood samples were collected in heparinized tubes via tail vein puncture starting at CIDR removal continuing every 6 h until a positive Predi′Bov® test was acquired or 36 h after CIDR removal. Whole blood (0.5 mL–1) was submitted to a proprietary 3-step procedure using a tube-stick applicator (40 min) to determine whether increased concentrations of LH were present. Stick applicators that turned blue were positive for increased concentrations of LH. Donors were artificially inseminated 12 and 24 h after a positive test, with specified sires, and embryos were nonsurgically collected 7 days after insemination. The Predi′Bov® test determined 91.6% (22/24) of the LH peaks occurred within 12 to 24 h after CIDR removal; 45.8% (11/24) occurred at 18 h; and 4% (1/24) at 30 h. A total of 203 viable embryos (average 8.5/donor) was collected with 174 embryos (average 9.2 ± 4.7/donor) from donors that exhibited oestrus and produced a positive test (19/24; 79.2%) and 29 embryos (average 5.8 ± 6.3/donor) from donors exhibiting silent oestrus that produced a positive test (5/24; 20.8%). One donor exhibited oestrus and never produced a positive test, but contributed 8 viable embryos to the total. In conclusion, Predi′Bov® cow-side usage could offer commercial utility when identifying oestrus is difficult or nonexistent. Increased detection of ovulation could help to identify optimal AI intervals, thereby increasing embryo production and limiting the use of expensive semen for desired donors.
28
Fjeld, Heidi. « Mohr, Sebastian2018. Being a sperm donor : masculinity, sexuality, and biosociality in Denmark. New York/Oxford : Berghahn Books. 185 pp. Hb. : US$120.00/£85.00. ISBN : 9781785339462. » Social Anthropology 27, no 3 (août 2019) : 568–70. http://dx.doi.org/10.1111/1469-8676.12682.
Texte intégral
29
Graham, Judy M., Maria E. Sabeta, Joseph T. Cooke, Elaine R. Berg et Wayne M. Osten. « A System's Approach to Improve Organ Donation ». Progress in Transplantation 19, no 3 (septembre 2009) : 216–20. http://dx.doi.org/10.1177/152692480901900304.
Texte intégralRésumé :
Using lessons learned from the US Department of Health and Human Services National Donation Breakthrough Collaborative, New York-Presbyterian Healthcare System (NYPHS) partnered with 5 donor service areas covering its member hospitals to improve donation across the system. By integrating established communication networks with the “spread” techniques of the Breakthrough Collaborative, the NYPHS identified hospital champions and best practices and established standardized outcome metrics. The improvements that resulted were a sustained increase of 40.23% in consent rate and an initial 41.7% increase in conversion rate during the first 6 months, although that conversion rate was not sustainable. During the 8 measured periods, 21 hospitals met or exceeded the 75% conversion rate during 1 or more quarters. NYPHS was able to spread these successes and outcome metrics through its established communication networks of quarterly report cards, regular senior leader meetings, and real-time access to a secure member-only Web site, thus keeping organ and tissue donation at the forefront of hospital leaders' priorities.
30
Drpić, Ivan. « Donor Portraits in Byzantine Art : The Vicissitudes of Contact between Human and Divine. By Rico Franses. New York : Cambridge University Press, 2018. xiii + 47 pp. $105.00 hardcover. » Church History 88, no 3 (septembre 2019) : 806–8. http://dx.doi.org/10.1017/s0009640719002051.
Texte intégral
31
Obajimi, G. O., et O. O. Ogunbode. « Assisted Reproductive Techniques and Gamete Donation ; Knowledge, Attitude and Willingness to Participate Among Students in a Nigerian Tertiary Institution ». Medical Journal of Zambia 47, no 1 (1 janvier 2020) : 8–15. http://dx.doi.org/10.55320/mjz.47.1.634.
Texte intégralRésumé :
Background: Infertility is a worldwide problem affecting about 10-15% of married couples and has social, economic and psychological implications1. A significant number of couples will require assisted reproduction following failure of common treatment options. Undergraduates form a rich source of potential gamete donors and it is imperative to assess their knowledge, attitude and willingness to participate in the expanding gamete donor programs in a developing country like Nigeria.
Objectives: This study aimed to assess the knowledge and attitude of participants about assisted reproduction and to further evaluate their willingness to donate gametes for assisted conception or act as surrogates.
Methodology: This was a cross-sectional descriptive study of 1150 participants consisting of 511 male students and 639 female students of the University of Ibadan. Participants were selected by simple random sampling technique. A semistructured, self-administered questionnaire was used to obtain information on sociodemographic characteristics, knowledge, attitude and willingness to participate in gamete donor programs. Participation was voluntary and data obtained was treated with utmost confidentiality. Data was analyzed using the Statistical Package for Social Sciences (IBM SPSS, New York) version 22.Descriptive statistics were generated, and the results summarized with the aid of a bar chart and frequency tables.
Results: Eight seven percent of the respondents had good knowledge of Assisted Reproductive Techniques (ART) and the most common source of awareness was the media (63.3%). More respondents were aware of sperm donation (75.5%)compared to egg donation (61.9%). Ninety percent of the participants were correctly able to identify the places where ART could be practiced in Nigeria.Most of the respondents (81.5%) supported ART services and the most common reason for not supporting was due to ethical considerations (45.1%). Only about 54.9% were willing to participate in gamete donor programs. Nine (0.8%) female respondents had previously participated in egg (oocyte) donation while none of the male respondents had ever donated sperm. About threequarters of the respondents demonstrated good knowledge about the practice of surrogacy.
32
Obajimi, G. O., et G. O. Obajimi. « Assisted Reproductive Techniques and Gamete Donation ; Knowledge, Attitude and Willingness to Participate Among Students in a Nigerian Tertiary Institution ». Medical Journal of Zambia 47, no 1 (7 mai 2020) : 8–15. http://dx.doi.org/10.55320/mjz.47.1.133.
Texte intégralRésumé :
Background: Infertility is a worldwide problem affecting about 10-15% of married couples and has social, economic and psychological implications1. A significant number of couples will require assisted reproduction following failure of common treatment options. Undergraduates form a rich source of potential gamete donors and it is imperative to assess their knowledge, attitude and willingness to participate in the expanding gamete donor programs in a developing country like Nigeria.
Objectives: This study aimed to assess the knowledge and attitude of participants about assisted reproduction and to further evaluate their willingness to donate gametes for assisted conception or act as surrogates.
Methodology: This was a cross-sectional descriptive study of 1150 participants consisting of 511 male students and 639 female students of the University of Ibadan. Participants were selected by simple random sampling technique. A semistructured, self-administered questionnaire was used to obtain information on sociodemographic characteristics, knowledge, attitude and willingness to participate in gamete donor programs. Participation was voluntary and data obtained was treated with utmost confidentiality. Data was analyzed using the Statistical Package for Social Sciences (IBM SPSS, New York) version 22.Descriptive statistics were generated, and the results summarized with the aid of a bar chart and frequency tables.
Results: Eight seven percent of the respondents had good knowledge of Assisted Reproductive Techniques (ART) and the most common source of awareness was the media (63.3%). More respondents were aware of sperm donation (75.5%)compared to egg donation (61.9%). Ninety percent of the participants were correctly able to identify the places where ART could be practiced in Nigeria.Most of the respondents (81.5%) supported ART services and the most common reason for not supporting was due to ethical considerations (45.1%). Only about 54.9% were willing to participate in gamete donor programs. Nine (0.8%) female respondents had previously participated in egg (oocyte) donation while none of the male respondents had ever donated sperm. About threequarters of the respondents demonstrated good knowledge about the practice of surrogacy.
33
Forshall, Georgie. « Hertz, R. and Nelson, M.K.Random Families : Genetic Strangers, Sperm Donor Siblings and the Creation of New Kin, New York : Oxford University Press2019. 296 pp $27.95 (hbk) $9.99 (ebk) ISBN 978‐0‐19‐088827‐5 ». Sociology of Health & ; Illness 42, no 1 (18 novembre 2019) : 210–11. http://dx.doi.org/10.1111/1467-9566.13033.
Texte intégral
34
Rothwell, Ian P. « Early Transition Metal Clusters with Pi-Donor Ligands Edited by Malcolm H. Chisholm (Indiana University). VCH : New York. 1995. xii + 289 pp. $115.00. ISBN 1-56081-684-8. » Journal of the American Chemical Society 119, no 25 (juin 1997) : 5991–92. http://dx.doi.org/10.1021/ja9553009.
Texte intégral
35
Adams, Patricia L. « Book Review Living Donor Organ Transplantation Edited by Rainer W.G. Gruessner and Enrico Benedetti. 791 pp., illustrated. New York, McGraw-Hill, 2008. $205. 978-0-07-145549-7 ». New England Journal of Medicine 359, no 3 (17 juillet 2008) : 324–25. http://dx.doi.org/10.1056/nejmbkrev0804312.
Texte intégral
36
Kosuri, Satyajit, Tara F. Wolff, Courtney Byam, Emily Lauer, Yeon Yoo, Miguel-Angel Perales, Sergio A. Giralt, Andromachi Scaradavou, Doris M. Ponce et Juliet N. Barker. « Prospective Evaluation of Cord Blood (CB) & ; Haplo-Identical Donor Availability Reveals Compromised Donor Access for Both Graft Types in Minorities and High Rates of Failure to Clear Haplo Donors in Adult Patients ». Blood 126, no 23 (3 décembre 2015) : 2027. http://dx.doi.org/10.1182/blood.v126.23.2027.2027.
Texte intégralRésumé :
Abstract Background: Many patients in need of hematopoietic allografts without matched siblings do not have any 8/8 HLA-matched unrelated volunteer donors (URD). This is especially true in patients of non-European & mixed ancestries & this applies to 50% of patients undergoing URD searches at our center. While unrelated donor CB & haploidentical (haplo) related donors offer alternative graft sources their availability in all patient populations is not established. Methods: We prospectively evaluated the availability of CB & haplo grafts 9/2012 - 7/2015 in a phase II clinical trial of double unit CBT (dCBT) supplemented by haplo CD34+ cells in patients with hematologic malignancies lacking an 8/8 HLA-matched URD. CB units required a cryopreserved TNC dose ≥ 1.5 x 107 /kg/unit, were ≥ 4/6 HLA-A,-B antigen, -DRB1 allele matched, & high resolution 8 HLA-allele match & CD34+ cell dose were also considered. Standard criteria were used to define donor eligibility for haplo PBSC collection. Reasons for failure of haplo donor clearance were classified as either medical ineligibility or psychosocial (including financial inability to relocate to our transplant center, international donors unable to come to the US, donor refusal or withdrawal of consent during workup, donor imprisonment, or patient refusal to approach the donor for collection). Results: 89 patients [median age 50 years (range 15-68)] were evaluated. Diagnoses included 58 acute leukemias, 10 MDS/ myeloproliferative disorders, & 21 NHL/ Hodgkins lymphomas. Evaluation of CB graft &/or haplo donor availability revealed 3 patient groups. Group 1 (59/89, 66% of the total) had both suitable CB grafts & haplo donors and underwent dCBT-haplo CD34+ transplants. 33% were non-European & their median weight was 78 kg (range 33-133). The CB grafts had a median infused TNC of 2.4 (larger unit) & 1.9 (smaller unit) x 107/kg with a median 5/8 (range 2-7/8) donor-recipient HLA-match whereas the 59 haplos (median age 36 years, range 15-71) included 17 siblings, 9 parents, 27 children, & 6 extended family. In Group 1, the first haplo chosen was cleared for donation in 52/59 (88%) patients whereas 6/59 (10%) required work-up of 2-4 haplos/ patient for a total of 16 donors who failed clearance for medical or psychosocial reasons. The remaining patient had pan-donor specific HLA antibodies to 5 haplos & subsequently a 7/8 HLA-matched nephew was secured. Group 2 (17/89, 19% of the total) received only dCB grafts due to failure to identify a suitable haplo donor. Group 2 patients were more likely to be non-European (65%) but had a similar weight (median 78 kg, range 55-118) as Group 1. The CB grafts were also similar to Group 1 (median infused TNC 2.2 & 1.5 x 107/kg & median donor-recipient HLA-match 5/8, range 3-8/8). Of these 17 dCBT only patients, 6 had no eligible haplos identified within their extended family whereas in 8 patients 1-4 haplos/ patient failed to clear for medical reasons, combinations of medical & psychosocial reasons, or pursuit of haplos failed due to a combination of medical failure & subsequent transplant urgency. Of the remaining patients, 2 had haplos who failed for purely psychosocial reasons, & in 1 the transplant was too urgent to delay to complete donor clearance. In this group a total of 19 haplos failed to clear. Finally, Group 3 (13/89, 15% of the total) had no dCB grafts + no haplo grafts. They were nearly all (85%) non-European including 7 patients of African ancestry & they had a higher weight (median 95 kg, range 52-143). One of these patients received a haplo transplant, 3 had no haplos identified, & in 9 patients clearance of potential haplos was not determined to date, or they pursued alternative therapy, were lost to follow-up, or their disease progressed. Conclusions: In this study, 15% of patients had no CB grafts & these patients were predominantly non-European with a high weight. Additionally, over 20% of patients had no haplo grafts & compromised haplo donor availability was common especially in minority patients. This data demonstrates that even in patients with identified haplos, donor clearance cannot be assumed & the need for workup of multiple haplos/ patient can delay admission & substantially add to transplant costs. These observations support continued investment in public CB inventories to provide a readily available graft especially for minority patients who are at increased risk for inability to identify a CB &/or haplo donor. Disclosures Perales: National Marrow Donor Program: Membership on an entity's Board of Directors or advisory committees; Merck: Honoraria; Amgen: Honoraria; Incyte: Honoraria; Seattle Genetics: Honoraria. Giralt:TAKEDA: Consultancy, Honoraria, Research Funding; JAZZ: Consultancy, Honoraria, Research Funding, Speakers Bureau; AMGEN: Consultancy, Research Funding; SANOFI: Consultancy, Honoraria, Research Funding; CELGENE: Consultancy, Honoraria, Research Funding. Scaradavou:National Cord Blood Program- New York Blood Center: Employment.
37
Tran, Tu M., Daniel Fraser, Christina L. Gillmor, Edwin Roberts, Patricia Dahl, Alessandro Meduri et Stephen C. Kaufman. « Effect of Double Povidone-Iodine Wash on Rate of Positive Donor Corneoscleral Rim Cultures : A 7-Year Eye Bank Analysis ». Eye Banking and Corneal Transplantation 2, no 3 (31 août 2023) : e0014. http://dx.doi.org/10.1097/ebct.0000000000000014.
Texte intégralRésumé :
Introduction: Starting October 2018, the Eye Bank Association of America modified the national standard protocol to incorporate a double povidone-iodine (P-I) wash at the time of procurement. Purpose: To determine if double P-I wash resulted in a reduced rate of positive donor rim cultures. Methods: A comprehensive database review was performed on consecutive corneoscleral tissue handled by The Eye-Bank for Sight Restoration (New York, NY) from January 2015 to December 2021. The primary outcome was the rate of positive corneoscleral rim cultures for bacteria or fungus. Secondary outcomes included rate of postoperative infection (eg, keratitis or endophthalmitis). For analysis, statistical significance was determined as P < 0.05. Results: Of 6079 corneal transplants performed, 3491 were done before implementation of double P-I wash with a total culture positive rate of 0.43%. There were 2588 corneal transplants performed after implementation of double P-I wash with a total positive culture rate of 0.23%, which is a significant reduction (Poisson regression incidence rate ratio [IRR] 0.35 [95% CI 0.089–0.61], P = 0.007). The most common organisms preimplementation were Candida species (46.7% of culture-positive rims), whereas no candida species were isolated postimplementation (logit regression, P = 0.034). Cutibacterium acnes culture positivity rate increased postimplementation to 50.0% versus 13.3% preimplementation (logit regression, P = 0.116). The rate of postoperative infection was 1.55% and 1.00% for preimplementation and postimplementation, respectively (IRR 0.30 [95% CI, 0.18–0.50], P < 0.001). Conclusions: The use of double P-I wash was associated with a decrease in the rate of positive corneoscleral donor rim cultures and a decrease in the rate of postoperative infection.
38
Thida, Aye Mon, Burak Erdinc, Sylvester Homsy, Firas Muhammad Jafri, Edwin Chiu et Jason Parker Gonsky. « Health disparities in acute myeloid leukemia : A decade-long analysis of Afro-Caribbean patients in a safety net New York City hospital. » Journal of Clinical Oncology 42, no 16_suppl (1 juin 2024) : e18515-e18515. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e18515.
Texte intégralRésumé :
e18515 Background: Acute Myeloid Leukemia (AML) in the Afro-Caribbean population is associated with poor outcomes due to disparities in health insurance and access to healthcare resources, among other factors, when compared to survival data in the national SEER database. This study reviews clinical characteristics and treatment outcomes of a cohort of 51 Afro-Caribbean patients who were diagnosed with AML and treated in the past 10 years in a urban safety net hospital in Brooklyn, New York. Methods: This is a retrospective review of patients diagnosed and treated for AML at New York City Health and Hospitals/Kings County from 2012 to 2022. Electronic Health Data was reviewed for clinicopathologic data and treatment outcomes. Analysis was performed through descriptive statistics with specific focus on insurance status and survival outcomes. Results: Our AML patient cohort had a mean age of 66, with 84% of patients identifying as Afro-Caribbean, and 51% being female. In this cohort, the AML risk stratification distribution based on 2022 European LeukemiaNet Risk classification includes 21 (41%) patients in the adverse-risk group, 23 (45%) patients in the intermediate-risk group, and 7 (14%) patients in the favorable-risk group. Of the 36 patients with molecular analysis data, 9 (25%) harbored a mutation in FLT3-ITD. Healthcare disparities are evident in insurance coverage, as 58% of patients lacked medical insurance, 19% had Medicare/Medicaid, and 23% had private insurance. At the time of this retrospective chart review, 35% of patients lacked any follow-up information, including appointments or status updates regarding their condition, vital status, or engagement with healthcare, possibly due to missed appointments, transfers, mortality, or other reasons. Of the 27 patients who were deemed transplant eligible, three (11%) successfully completed allogeneic bone marrow transplant. Reasons for non-transplantation include lack of a compatible donor, inadequate social support, insurance-related challenges, or patient refusal. Patients who completed induction and consolidation treatment with documented follow-up had a 23% survival rate at the five-year mark, compared to 31.7% overall survival rate reported in SEER data from 2013 to 2019. Conclusions: Our study highlights persistent healthcare disparities in Afro-Caribbean AML patients leading to poor survival outcomes. Despite treatment advancements, challenges related to insurance coverage, social support, follow-up care, and access to restricted, advanced care remain. Addressing these disparities calls for targeted interventions to enhance access and support systems for this vulnerable population.
39
Thome, Joseph, Melissa Ventevogel, Yoshiaki Ohmura, Tomoaki Kato, Gregory Sempowski et Donna Farber. « Human thymopoiesis and naïve T cell maintenance throughout life (LYM7P.724) ». Journal of Immunology 192, no 1_Supplement (1 mai 2014) : 193.12. http://dx.doi.org/10.4049/jimmunol.192.supp.193.12.
Texte intégralRésumé :
Abstract The extent to which thymopoieis is diminished over the human lifespan and how this affects the naïve T cell repertoire in peripheral tissue sites is not well characterized. In collaboration with the New York Organ Donor Network, we have attained novel access to thymus and secondary tissues from deceased organ donors. From this, it is possible to correlate naïve T cell development to distribution in tissue sites from the same individual effectively identifying when functional thymopoiesis is halted and how this affects the naïve T cell pool over time. We have found marked cessation of functional thymopoiesis in donors over 40 years of age but strikingly naïve T cells are maintained in lymph node tissue sites for decades undergoing low levels of proliferation and turnover comprising over 20% of total T cells in donors aged 40-73. When profiling double negative (DN) stage thymocytes using CD25 and CD44, DN1 thymocytes accumulate in donors with negligible thymic output indicating a lack of progenitor cells to progress to maturation while identified recent thymic emigrants (RTE) exhibit differential distribution and regulation in tissues during periods of active thympopoiesis but are evenly distributed in the spleen and lymph nodes when the export of new naïve T cells is halted. Together this indicates that naïve T cell populations are uniquely maintained as a function of thymic activity in order to preserve the ability to respond to new pathogen throughout the human lifetime.
40
Menzo, Daniel J. « Preserving Patchogue : A Small Institution Rehouses and Digitizes Glass Plate Negatives ». Collections : A Journal for Museum and Archives Professionals 14, no 2 (juin 2018) : 195–205. http://dx.doi.org/10.1177/155019061801400206.
Texte intégralRésumé :
In 2015, the Greater Patchogue Historical Society in Long Island, New York, received a gift of nearly 2,000 glass plate negatives dating from the early 20th century. While the donor alluded to rare images of this small town and its people, the collection presented a series of preservation concerns. Many of the objects were soiled, and almost all were still in their original acidic paper sleeves. Determined to both protect and utilize the collection, this small institution, with the assistance of a graduate student intern, formalized a preservation plan that also created multiple points of access to the visual and historical information that these objects contained. After minimally cleaning, rehousing, and photographing a selected portion of the negatives, the digital files were later processed with editing software so that the organization's members and local citizens could see the historic images. In addition to digitizing the negatives, the original sleeves were imaged to preserve valuable information, such as people's names, the location of views, or a negative's date. This ongoing project is an example of how smaller institutions can make a meaningful influence in their local communities by preserving photographic objects and implementing methods of digitization.
41
Azizah, Nur, et Fahriyya Noor Ahsana. « Role of UN Women in Addressing Women's Rights in Afghanistan under Taliban ». Journal of Islamic World and Politics 7, no 2 (7 décembre 2023) : 140–50. http://dx.doi.org/10.18196/jiwp.v7i2.57.
Texte intégralRésumé :
The current condition of Afghanistan under the Taliban government creates considerable humanitarian problems, especially concerning the rights of women and girls. The Taliban threatens Afghan women by implementing several detrimental policies prohibiting them from going to school, working, and leaving the house. The Taliban restricted the movement of women workers and created an insecure space. This research aims to explain the role of UN Women in responding to humanitarian issues in Afghanistan, especially those related to women. This study used a descriptive method with literature sources such as books, journals, notes, and related reports. The findings indicated that UN Women is committed to assisting Afghan women in restoring their rights under Taliban rule. UN Women, as an International Organization, plays a role as an arena for Afghan women by facilitating women to speak, one of which is in a series of events at the UN Security Council Open Debate on Women, Peace, and Security, which was held at the UN Headquarters in New York. UN Women also works as a donor by providing financial assistance, which will be allocated to the needs of Afghan women. In addition, UN Women acts as an advocate through various activities.
42
Fisher, Jim R. « The Wild Duck Chase : Inside the Strange and Wonderful World of the Federal Duck Stamp Contest Martin J. Smith. 2013. Bloomsbury Publishing, New York, NY. 272 pages, black & ; white illustrations. ISBN 9781620403075. $16.00 (Paperback). Also available as an ». Journal of Field Ornithology 85, no 2 (26 mai 2014) : 223–24. http://dx.doi.org/10.1111/jofo.12063_2.
Texte intégral
43
Mikles, Bethany, Monica Bhatia, Suzette O. Oyeku et Nancy S. Green. « Hematology Provider Perspectives On Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease ». Blood 120, no 21 (16 novembre 2012) : 4276. http://dx.doi.org/10.1182/blood.v120.21.4276.4276.
Texte intégralRésumé :
Abstract Abstract 4276 Introduction: Hematopoietic stem cell transplantation (HSCT) from an HLA matched donor is the only curative therapy for sickle cell disease (SCD), with sibling donor survival rates approaching 95%. Referral from the primary hematologist for transplant evaluation is a key step in the process. Study aims were to assess pediatric SCD providers for: 1) Current perspectives and referral patterns; 2) Whether perspectives differ for those practicing at a transplant center. Methods: All pediatric hematology providers at the designated newborn screening hemoglobinopathy centers within the seven state New York-Mid-Atlantic Consortium (NYMAC) were anonymously surveyed. Descriptive statistics and chi squared test or Fisher's exact test were used for analysis. Results: Of 197 pediatric SCD providers contacted through the NYMAC listserv, 104 (53%) responded, predominantly hematologists. Half (53%) of responders practice at sites performing HSCT for pediatric SCD. Overall, transplant centers had larger SCD patient populations (p<0.001). Provider referral pattern: Most providers (89%) had referred at least one child with SCD for transplant evaluation within the past two years. A higher proportion of practitioners at a transplant center had referred at least 3 patients for transplant evaluation, 84% vs. 53% (p=0.001). Patient demographics for transplant eligibility: Overall, 77% would limit HSCT to children with HbSS or HbS-β° thalassemia. Nearly half (44%) were less likely to refer a child for evaluation with SCD than with β-thalassemia major (no significant difference (NS) by practice setting). Those practicing at transplant centers were more certain of 6–16 years as an optimal transplant age (100% vs. 84%; p=0.004). Indications: Single disease indications for transplant referral were stroke, acute chest syndrome or family request. Less commonly cited were abnormal TCD (31%) or clinically silent stroke (34%). Commonly listed treatment indications were a new stroke despite chronic transfusion (82%) or poor response to hydroxyurea (71%), not iron overload (22%) (NS by practice setting). Donor: Most would offer HSCT to a child with multiple SCD complications with (95%) or without (66%) a sibling match; 37% would refer a child with limited disease despite a sibling donor (NS by practice setting). Acceptable outcomes: The majority (78%) agreed that HSCT can improve health. Risk of mortality, lack of sibling match, and infertility were most commonly cited as barriers to referral. Most identified acceptable overall survival rates as 90–100% (divided between ≥90% or 95–100%). Providers at transplant centers were more likely to accept event-free survival rates of 75–90% (87% vs. 63%; p=0.002), rather than 95–100%. Limitations: While only one U.S. region was surveyed, NYMAC collectively diagnoses approximately 25% of all newborns with SCD (genes-r-us.uthscsa.edu). Actual referral patterns could not be verified. No adjustments were made for size of each practice site, nor were providers queried about perceived influence of payer mix or other patient demographics. Conclusions: Most pediatric SCD providers accept HSCT as a treatment option, especially for children with severe disease complications or inadequate response to other therapies. Practitioners at transplant centers reported making more referrals for evaluation, having a stronger preferred age and accepting a broader range of event-free survival. Overall, only one third of providers deem eligible those patients with a sub-clinical stroke or stroke risk, or those with a sibling donor if without major disease complications. Most providers prefer transplant for children with a limited sickle hemoglobinopathy type, and almost half favor transplantation for β-thalassemia major. These findings suggest varying enthusiasm for HSCT for pediatric SCD beyond donor availability or current survival outcomes. The SCD provider is a critical conduit for ushering families towards transplantation and weighing difficult risk-benefit ratios. Informed decisions and referral may benefit from provider education, especially for those not practicing at transplant centers, as well as professional guidelines about current indications and research comparing outcomes of SCD versus HSCT. Disclosures: No relevant conflicts of interest to declare.
44
Ammarudin, Ammarudin, et Wahyu Tri Atmojo. « WORKSHOP SIMA BATIK DESA TANJUNG REJO : PENGEMBANGAN DESAIN BATIK CAP ». Gorga : Jurnal Seni Rupa 12, no 2 (29 décembre 2023) : 380. http://dx.doi.org/10.24114/gr.v12i2.48154.
Texte intégralRésumé :
Sima Batik is very popular in Tanjung Rejo Village and other areas because of the good quality of its stamped batik so that the potential for income and profit is also visible in the large demand. However, the problem is that the available motifs are very limited. One of the reasons is constraints on time and operational management in producing batik. This means that the Sima Batik workshop has not yet developed batik stamps. The aim of this research is to find out the results of the design process and realization of stamped batik products which are characterized by Tanjung Rejo Village motifs in Tanjung Rejo Village and carry out development. The research is located in Tanjung Rejo Village Jl. Paluh 80 Hamlet XIV, Percut Sei Tuan District, Deli Serdang Regency, North Sumatra. The duration of the research is 3 months from January to March 2023. This type of research is Research and Development (R&D) using the 4-D development model, namely: define, design, develop and disseminate. The tools and materials needed for this development are A4 paper, pencils, erasers, rulers, drawing pens, colored pencils, computer equipment and printers. In the work procedure there are 4 stages, namely: making a stamped batik design, making a batik stamp canting, finishing, and product validation. Data collection techniques through observation, documentation, interviews and questionnaires. The instruments used in this development are cellphone cameras, notebooks, stationery and laptops. Data analysis techniques use validity analysis, practicality and effectiveness analysis. The results of the development are 6 motifs, namely: crab, mangrove, shrimp, bamboo, stork and rice motifs. From the six motifs, 3 types of stamped batik designs were produced which were applied to tote bags.Keywords: batik, stamp, design, development, motif. AbstrakSima Batik sangat diminati di Desa Tanjung Rejo dan daerah lainnya karena kualitas batik capnya yang bagus sehingga potensi penghasilan dan keuntungan juga terlihat dengan banyaknya permintaan. Namun, permasalahannya motif yang tersedia sangat terbatas. Salah satu alasannya adalah terkendala pada waktu dan manajemen operasional dalam memproduksi batik. Hal ini membuat workshop Sima Batik belum melakukan pengembangan cap batik. Tujuan dari penelitian ini adalah mengetahui hasil proses desain dan perwujudan produk batik cap yang bercirikan motif Desa Tanjung Rejo di Desa Tanjung Rejo dan dilakukan pengembangan. Penelitian berlokasi di Desa Tanjung Rejo Jl. Paluh 80 Dusun XIV, Kecamatan Percut Sei Tuan, Kabupaten Deli Serdang, Sumatera Utara. Durasi penelitian selama 3 bulan sejak Januari hingga Maret 2023. Jenis penelitian ini adalah Research and Development (R&D) dengan menggunakan model pengembangan 4-D yaitu: define, design, develop, dan disseminate. Alat dan bahan yang dibutuhkan dalam pengembangan ini adalah kertas A4, pensil, penghapus, penggaris, pulpen gambar, pensil warna, perangkat computer, dan printer. Dalam prosedur kerja terdapat 4 tahapan yaitu: membuat desain batik cap, membuat canting cap batik, finishing, dan validasi produk. Teknik pengumpulan data melalui observasi, dokumentasi, wawancara, dan kuesioner. Instrumen yang digunakan dalam pengembangan ini adalah kamera handphone, buku catatan, alat tulis, dan laptop. Teknik analisis data menggunakan analisis kevalidan, analisis kepraktisan dan efektivitas. Hasil pengembangan berupa 6 motif yaitu: motif kepiting, mangrove, udang, bambu, bangau, dan padi. Dari keenam motif dihasilkan 3 jenis desain batik cap yang luarannya diterapkan pada tote bag.Kata Kunci: batik, cap, desain, pengembangan, motif. Authors:Ammarudin : Universitas Negeri MedanWahyu Tri Atmojo : Universitas Negeri Medan References: Arini, A. M., & Ambar, B. (2011). Batik: Warisan Adiluhung Nusantara. Yogyakarta: Andi Offset.BPS Deli Serdang. (2014). Deli Serdang Dalam Angka/ Deli Serdang in Gambars. Deli Serdang: Badan Pusat Statistik Kabupaten Deli Serdang.Dhani, Siti Rama; Sri Wiratma & Misgiya. (2020). Tinjauan Hasil Kerajinan Batik Cap di Batik Sumut Medan Tembung Berdasarkan Warna, Motif, dan Harmonisasi. Gorga: Jurnal Seni Rupa, 9(1), 88-93.Delila, T., & Wiratma, S. (2017). Kerajinan Batik Dan Perkembangany Studi Kasus Pada Ardhina Batik Medan. Gorga: Jurnal Seni Rupa, 6(2), 89-102.KBBI. (2008). Kamus Bahasa Indonesia. Jakarta: Pusat BahasaKamala, N., & Adriani, A. (2019). Studi Tentang Motif Dan Pewarnaan Batik Cap Dengan Zat Pewarnaan Alam di Rumah Batik Dewi Busana Kecamatan Lunang Kabupaten Pesisir Selatan. Gorga: Jurnal Seni Rupa, 8(2), 303-307.Krevitsky, N. (1964). Batik: Art and Craft. New York: Reinhold Publishing Corporation New York an Art Horizons Book.Midah, M. (2020). “Sumber Desain Motif Sima Batik” Hasil Wawancara Pribadi: 31 Januari 2020, Percut Sei Tuan.Seragih, Y. G., & Azis, A. C. K. (2021). Tinjauan Hasil Gambar Ilustrasi Kartun dengan Objek Binatang. Ekspresi Seni: Jurnal Ilmu Pengetahuan dan Karya Seni, 23(2), 302-318.Thiagarajan, S., Semmel, D.S., & Semmel, M.I. (1974). Instructional Development for Training Teacher Of Exceptional Children. Bloomington Indiana: Indiana University.Widya, L. (2002). Fundamental of Art and Desain. Jakarta: Cybermedia College.
45
Rahman, Farah, Sarah Taimur, Melissa R. Gitman, Dallas Dunn, Emily Baneman, Risa Fuller, Samantha E. Jacobs, Meenakshi Rana et Timonthy Sullivan. « 583. Successful prevention of Strongyloides reactivation in liver transplant recipients with individualized screening and treatment : 10 year experience at a large transplant center in New York City ». Open Forum Infectious Diseases 7, Supplement_1 (1 octobre 2020) : S356. http://dx.doi.org/10.1093/ofid/ofaa439.777.
Texte intégralRésumé :
Abstract Background Strongyloides stercoralis is an intestinal nematode that can establish chronic, asymptomatic infection in human hosts. Following solid organ transplantation, subclinical infection may progress to hyperinfection syndrome, which is associated with high morbidity and mortality. However, the optimal approach for screening and treatment of strongyloidiasis in liver transplant candidates in non-endemic areas is unknown. Methods We performed a retrospective chart review of all liver transplant (LT) recipients from 2010–2019. All patients were evaluated by an infectious diseases physician prior to transplant, and screening for Strongyloides exposure (with Strongyloides IgG antibody) was typically limited to those with risk factors for strongyloidiasis. Only patients with positive serologic testing or other evidence of strongyloidiasis were treated with ivermectin. Results One thousand and seventy-two LT cases (including 15 retransplants) were reviewed. Serologic testing was perfomed in 664 cases, of which 36 (5.4% of those tested, 3.4% of total) were positive. Of the 36 cases with positive serologic testing, 31 had identifiable risk factors including birth place, travel or eosinophilia. Eosinophilia (defined as peripheral eosinophila greater than 5%) was noted in 3 of the 36 recipients who had positive serology. Of the total 36 cases with positive serology, 18 were treated both pre- and post-transplant, 7 were treated only pre-transplant and 9 were treated only post-transplant. One patient died prior to initiating treatment, and one did not have documented treatment. One patient with negative serologic testing was empirically treated due to persistent eosinophilia. There was one case of Strongyloides hyperinfection due to likely donor-derived infection. There were no cases of Strongyloides reactivation in the study cohort. Conclusion This study demonstrates that an individualized screening and treatment protocol can effectively prevent Strongyloides reactivation in LT recipients. Given the high mortality rate of Strongyloides hyperinfection, especially in solid organ transplant recipients, a methodical assessment of epidemiologic risk is essential for appropriate risk stratification and management of Strongyloides in LT candidates. Disclosures All Authors: No reported disclosures
46
Jobanputra, Ketan, James P. Toner, Rita Denoncourt et William E. Gibbons. « Crinone 8% (90 mg)∗∗Crinone 8%, Serono Laboratories, Inc., Norwell, Massachusetts. given once daily for progesterone replacement therapy in donor egg cycles22Sponsored by Columbia Research Laboratories, Inc., Rockville Centre, New York. » Fertility and Sterility 72, no 6 (décembre 1999) : 980–84. http://dx.doi.org/10.1016/s0015-0282(99)00390-8.
Texte intégral
47
Stevens, Cladd E., Carmelita Carrier, Carol Carpenter, Dorothy Sung et Andromachi Scaradavou. « HLA mismatch direction in cord blood transplantation : impact on outcome and implications for cord blood unit selection ». Blood 118, no 14 (6 octobre 2011) : 3969–78. http://dx.doi.org/10.1182/blood-2010-11-317271.
Texte intégralRésumé :
AbstractDonor-recipient human leukocyte antigen mismatch level affects the outcome of unrelated cord blood (CB) transplantation. To identify possible “permissive” mismatches, we examined the relationship between direction of human leukocyte antigen mismatch (“vector”) and transplantation outcomes in 1202 recipients of single CB units from the New York Blood Center National Cord Blood Program treated in United States Centers from 1993-2006. Altogether, 98 donor/patient pairs had only unidirectional mismatches: 58 in the graft-versus-host (GVH) direction only (GVH-O) and 40 in the host-versus-graft or rejection direction only (R-O). Engraftment was faster in patients with GVH-O mismatches compared with those with 1 bidirectional mismatch (hazard ratio [HR] = 1.6, P = .003). In addition, patients with hematologic malignancies given GVH-O grafts had lower transplantation-related mortality (HR = 0.5, P = .062), overall mortality (HR = 0.5, P = .019), and treatment failure (HR = 0.5, P = .016), resulting in outcomes similar to those of matched CB grafts. In contrast, R-O mismatches had slower engraftment, higher graft failure, and higher relapse rates (HR = 2.4, P = .010). Based on our findings, CB search algorithms should be modified to identify unidirectional mismatches. We recommend that transplant centers give priority to GVH-O-mismatched units over other mismatches and avoid selecting R-O mismatches, if possible.
48
Ludwig, Bernd, Johanna Schneider, Daniela Föll et Qian Zhou. « Antibody-mediated rejection with detection of de novo donor-specific anti-human leucocyte antigen Class II antibodies 3 years after heart transplantation : a case report ». European Heart Journal - Case Reports 4, no 1 (25 janvier 2020) : 1–4. http://dx.doi.org/10.1093/ehjcr/ytz246.
Texte intégralRésumé :
Abstract Background Antibody-mediated rejection (AMR) in cardiac transplantation may manifest early within the first weeks after transplantation but also late after months to years following transplantation resulting in mild heart failure to cardiogenic shock. While patients with early cardiac AMR are less affected and seem to have survival rates comparable to transplant recipients without AMR, late cardiac AMR is frequently associated with graft dysfunction, fulminant forms of cardiac allograft vasculopathy, and a high mortality rate. Nevertheless, AMR of cardiac allografts remains difficult to diagnose and to treat. Case summary We report the case of a 47-year-old male patient with late AMR of the cardiac allograft 3 years after heart transplantation. Antibody-mediated rejection was confirmed by endomyocardial biopsy and the presence of donor-specific antibodies (DSA). The patient was treated with high dose of prednisolone, plasmapheresis, intravenous Gamma Globulin, rituximab, immunoadsorption, and bortezomib. Under this treatment regimen left ventricular ejection fraction and pro B-type natriuretic peptide recovered, and the patient improved to New York Heart Association Class I. Currently, 3 years after the diagnosis of cardiac AMR, graft function continues to be nearly normal, and there is no evidence for transplant vasculopathy. Discussion This case illustrates that AMR can occur at any time after transplantation. Although graft function fully recovered after treatment in our patient, the level of DSA remained high, suggesting that DSA may not be a reliable parameter to determine the intensity and duration of the therapy.
49
Travanty, Emily, Bin Zhou, Hongbo Zhang, Y. Peter Di, John F. Alcorn, David E. Wentworth, Robert Mason et Jieru Wang. « Differential Susceptibilities of Human Lung Primary Cells to H1N1 Influenza Viruses ». Journal of Virology 89, no 23 (16 septembre 2015) : 11935–44. http://dx.doi.org/10.1128/jvi.01792-15.
Texte intégralRésumé :
ABSTRACTHuman alveolar epithelial cells (AECs) and alveolar macrophages (AMs) are the first lines of lung defense. Here, we report that AECs are the direct targets for H1N1 viruses that have circulated since the 2009 pandemic (H1N1pdm09). AMs are less susceptible to H1N1pdm09 virus, but they produce significantly more inflammatory cytokines than AECs from the same donor. AECs form an intact epithelial barrier that is destroyed by H1N1pdm09 infection. However, there is significant variation in the cellular permissiveness to H1N1pdm09 infection among different donors. AECs from obese donors appear to be more susceptible to H1N1pdm09 infection, whereas gender, smoking history, and age do not appear to affect AEC susceptibility. There is also a difference in response to different strains of H1N1pdm09 viruses. Compared to A/California04/09 (CA04), A/New York/1682/09 (NY1682) is more infectious and causes more epithelial barrier injury, although it stimulates less cytokine production. We further determined that a single amino acid residue substitution in NY1682 hemagglutinin is responsible for the difference in infectivity. In conclusion, this is the first study of host susceptibility of human lung primary cells and the integrity of the alveolar epithelial barrier to influenza. Further elucidation of the mechanism of increased susceptibility of AECs from obese subjects may facilitate the development of novel protection strategies against influenza virus infection.IMPORTANCEDisease susceptibility of influenza is determined by host and viral factors. Human alveolar epithelial cells (AECs) form the key line of lung defenses against pathogens. Using primary AECs from different donors, we provided cellular level evidence that obesity might be a risk factor for increased susceptibility to influenza. We also compared the infections of two closely related 2009 pandemic H1N1 strains in AECs from the same donor and identified a key viral factor that affected host susceptibility, the dominance of which may be correlated with disease epidemiology. In addition, primary human AECs can serve as a convenient and powerful model to investigate the mechanism of influenza-induced lung injury and determine the effect of genetic and epigenetic factors on host susceptibility to pandemic influenza virus infection.
50
Altmann, Jeanne. « Observing Animal Behaviour : Design and Analysis of Quantitative Data. By Marian Stamp Dawkins. Oxford and New York : Oxford University Press. $120.00 (hardcover) ; $55.00 (paper). viii + 158 p. ; ill. ; index. ISBN : 978‐0‐19‐856935‐0 (hc) ; 978‐0‐19‐856936‐7 (pb). 2007. » Quarterly Review of Biology 85, no 1 (mars 2010) : 101. http://dx.doi.org/10.1086/650245.
Texte intégral