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Articles de revues sur le sujet "SP-ELISA"
CIMINO, R. O., M. MONJE RUMI, P. RAGONE, J. LAUTHIER, A. ALBERTI D'AMATO, I. R. LÓPEZ QUIROGA, J. F. GIL et al. « Immuno-enzymatic evaluation of the recombinant TSSA-II protein ofTrypanosoma cruziin dogs and human sera : a tool for epidemiological studies ». Parasitology 138, no 8 (26 avril 2011) : 995–1002. http://dx.doi.org/10.1017/s0031182011000540.
Texte intégralRamírez-Reveco, Alfredo, Gerardo Velásquez, Christopher Aros, Gabriela Navarrete, Franz Villarroel-Espíndola, Maritza Navarrete, Alberto Fica et al. « Performance estimation of two in-house ELISA assays for COVID-19 surveillance through the combined detection of anti-SARS-CoV-2 IgA, IgM, and IgG immunoglobulin isotypes ». PLOS ONE 18, no 2 (6 février 2023) : e0270388. http://dx.doi.org/10.1371/journal.pone.0270388.
Texte intégralWahyuningsih, Sri P. Astuti, R. Warsito, Hastari Wuryastuti et Kamiso H.N. « DETEKSI Streptococcus Sp PADA Clarias gariepinus MENGGUNAKAN AMPLIFIED ENZYME-LINKED IMMUNOSORBENT ASSAY ». Berkala Penelitian Hayati 5, no 1 (31 décembre 1999) : 23. http://dx.doi.org/10.23869/bphjbr.5.1.19993.
Texte intégralOliveira, Trícia Maria F. de Sousa, Patrícia I. Furuta, Débora de Carvalho et Rosangela Z. Machado. « Study of cross-reactivity in serum samples from dogs positive for Leishmania sp., Babesia canis and Ehrlichia canis in enzyme-linked immunosorbent assay and indirect fluorescent antibody test ». Revista Brasileira de Parasitologia Veterinária 17, no 1 (mars 2008) : 7–11. http://dx.doi.org/10.1590/s1984-29612008000100002.
Texte intégralMETZGER-BODDIEN, CHRISTOPH, ANJA BOSTEL et JOHANNES KEHLE. « AnDiaTec Salmonella sp. PCR-ELISA for Analysis of Food Samples ». Journal of Food Protection 67, no 8 (1 août 2004) : 1585–90. http://dx.doi.org/10.4315/0362-028x-67.8.1585.
Texte intégralGarcia-de-Lomas, J., C. Morales, M. A. Grau et A. Mir. « Detection of Candida sp. mannan antigen by indirect ELISA-inhibition ». Mycopathologia 102, no 3 (juin 1988) : 175–78. http://dx.doi.org/10.1007/bf00437401.
Texte intégralParé, Julie, Sharon K. Hietala et Mark C. Thurmond. « An Enzyme-Linked Immunosorbent Assay (ELISA) for Serological Diagnosis of Neospora Sp. Infection in Cattle ». Journal of Veterinary Diagnostic Investigation 7, no 3 (juillet 1995) : 352–59. http://dx.doi.org/10.1177/104063879500700310.
Texte intégralBoot, R., H. C. W. Thuis, J. L. Veenema et R. G. H. Bakker. « An enzyme-linked immunosorbent assay (ELISA) for monitoring rodent colonies for Pasteurella pneumotropica antibodies ». Laboratory Animals 29, no 3 (1 juillet 1995) : 307–13. http://dx.doi.org/10.1258/002367795781088306.
Texte intégralNIU, QINGLI, ZHIJIE LIU, JIFEI YANG, PEIFA YU, YUPING PAN, BINTAO ZHAI, JIANXUN LUO, GUIQUAN GUAN et HONG YIN. « Expression of sheep pathogen Babesia sp. Xinjiang rhoptry-associated protein 1 and evaluation of its diagnostic potential by enzyme-linked immunosorbent assay ». Parasitology 143, no 14 (17 octobre 2016) : 1990–99. http://dx.doi.org/10.1017/s0031182016001293.
Texte intégralQuispe Pari, Elizabeth. « Diagnóstico de teniasis humana mediante elisa coproantígeno y microscopía tradicional en poblaciones rurales de Puno - Perú. » Revista Investigaciones Altoandinas - Journal of High Andean Investigation 17, no 3 (30 décembre 2015) : 477. http://dx.doi.org/10.18271/ria.2015.152.
Texte intégralThèses sur le sujet "SP-ELISA"
Maciel, Marilene Oliveira dos Santos. « ELISA plasmônica na detecção de anticorpos IgG anti-leishmania sp. / ». Araçatuba, 2019. http://hdl.handle.net/11449/182290.
Texte intégralResumo: O cão tem sido alvo do controle da Leishmaniose Visceral (LV), pois são reservatórios potenciais de Leishmania infantum e desempenham um papel fundamental na cadeia epidemiológica da doença no homem. Portanto, o diagnóstico da leishmaniose canina (Lcan) no Brasil tem sido um desafio para os órgãos de controle de endemias, uma vez que apresentam limitações quanto à sensibilidade e especificidade em áreas endêmicas. Nesta perspectiva a presente pesquisa objetivou desenvolver e validar um ELISA plasmônica indireto rK28 (pELISA) para o diagnóstica da Lcan. Para o desenvolvimento do pELISA, foram realizados diferentes ensaios de otimização, determinação das concentrações ideais de peróxido de hidrogênio, íons ouro, anticorpo IgG anti-dog biotinilado e também do soro. Para a validação do ensaio, 170 amostras de soro de cães de área endêmica para Lcan e 26 amostras de cães saudáveis de área não endêmica para a doença foram testadas pelo pELISA e comparadas com ELISA indireto rk28 e com o teste imunocromatográfico (Dual Path Platform, TR_DPP®) usando como teste padrão-ouro o qPCR em amostras de sangue e/ou swab de subconjuntival. O ensaio foi padronizado com as concentrações de 250 μM de peróxido de hidrogênio, 0,30 mM de íons ouro e a melhor diluição do conjugado de estreptavidina-catalase foi de 1/50. O TR_DPP®, ELISA indireto rK28 e pELISA apresentaram sensibilidade de 79,0%, 89,5% e 94,7% e especificidade de 90,1%, 91,4% e 100,0%, respectivamente. Os maiores valores preditivos po... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Dogs have been the target of control of Visceral Leishmaniasis (VL) in humans, as they are potential reservoirs of Leishmania infantum and play a key role in the epidemiological chain of the disease. Therefore, the diagnosis of Canine Leishmaniasis (CanL) in Brazil has been a challenge for endemic control organs, since they have limitations on sensitivity and specificity in endemic areas. In this perspective the present research aimed to develop and validate an indirect plasmonic ELISA rK28 (pELISA) for the diagnosis of CanL. For the development of pELISA, different concentrations of hydrogen peroxide, gold ions, biotinylated anti-dog IgG antibody and serum were tested in order to establish ideal values to each parameter. For the validation of the assay, 170 dog serum samples from endemic area to CanL and 26 healthy dog samples from an area nonendemic to the disease were tested by pELISA and compared with indirect ELISA rk28 and the imunocromatografic test (Dual Path Platform, TR_DPP®) using as gold standard assay the real-time PCR in blood samples and/or subconjunctival swab. The assay was standardized with the concentrations of 250 μM hydrogen peroxide, 0.30 mM gold ions, and dilution of the streptavidin-catalase conjugate of 1/50. The TR_DPP®, indirect ELISA rK28 and pELISA presented sensitivity of 79.0%, 89.5% and 94.7% and specificity of 90.1%, 91.4% and 100%, respectively. The highest predictive positive (100%), negative (99.3%) and accuracy (99.4%) values were observed... (Complete abstract click electronic access below)
Mestre
Casimiro, Angélica Maria. « Padronização e avaliação de método sorológico ELISA para detecção de anticorpos IgG anti-Cryptosporidium sp ». Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-06032015-145009/.
Texte intégralThe aim of the present study was to standardize an immunoenzymatic assay, ELISA, for detection of IgG antibodies to Cryptosporidium sp for use in epidemiologic studies on cryptosporidiosis. For antigen preparation, oocysts were obtained from fecal samples of orally infected calves. A modified sucrose gradient, concentration technique was used for recovered and purification of oocysts, which were ruptured by using freezethaw cycles and ultra-sonication. Positive control sera were chosen among the Parasitology workers, who presented anti-Cryptosporidium antibodies and had been exposed to this parasite, because of their activities in the laboratory; and negative control sera were chosen among the ones with optical density (O.D.) readings lower than 0,300 at ELISA for anti- Cryptosporidium antibodies. Oifferent groups of sera from clinically normal individuais (parasitology workers, blood donors, pregnant patients) or with other parasite infection (cysticercisis, toxoplasmosis, schistosomiasis, Chagas disease, leishmaniasis) were evaluated for the presence of Cryptosporidium antibodies. The higher frequency was observed for the group of patients with Chagas disease (66.6%) and the lower frequency for the group patients with schistosomiasis and toxoplasmosis (20.0%). The specificity of the Cryptosporidium-ELISA test was demonstrated when significant reduction of the 0.0. readings was observed for some serum samples after absorption of the anti-Cryptosporidium antibodies. Also, in the group of pregnant patients, the high frequency of 52.0% for anti-Cryptosporidium antibodies when compared to the low frequency of 14.6% for anti-Toxoplasma antibodies might suggest possible absence of cross reactions between these two closely related parasite antigens. The ELISA for detection of anti-Cryptosporidium antibodies, as standardized in the present work, can constitute a good toel for epidemiological studies of cryptosporidiosis.
Santiago, Maria Emília Bodini [UNESP]. « Investigação de Leishmania spp. em Didelphis spp. (Linnaeus, 1756) na cidade de Bauru-São Paulo ». Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/94690.
Texte intégralCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
No período de março de 2005 a fevereiro de 2006, coletaram-se amostras de sangue e medula óssea de 112 gambás (Didelphis sp.) na região urbana da cidade de Bauru,estado de São Paulo, Brasil, com o objetivo de se verificar a possibilidade destes animais atuarem como reservatórios de Leishmania. Em amostras de soro foram detectados, anticorpos anti – Leishmania sp. pela técnica de ensaio imunoenzimático em fase sólida indireto (ELISA) e em medula óssea o DNA de Leishmania sp foi amplificado por meio da reação em cadeia pela polimerase (PCR) utilizando os primers 13A e 13B. Na reação de ELISA das 107 amostras analisadas 71,02% apresentaram se positivas, no PCR das 112 amostras de medula óssea analisadas 91,56% foram positivas. A evidência de fatores epidemiológicos de risco como, a presença do parasito circulante e dos vetores levam a acreditar que o gambá possa estar incluindo no ciclo da transmissão da Leishmaniose na cidade de Bauru.
Between March 2005 and February 2006, blood and Bone marrow samples were collected from 112 Opossums (Didelphis sp.) in the urban region of Bauru city - São Paulo state - Brazil . The objective was to verify the possibilities of these animals to be the reservoir of Leishmaniasis. Anti- Leishmania sp. antibodies were detected in serum by the Enzyme-Linked Immunosorbent Assay (ELISA) and DNA from Leishmania sp was detected in bone marrow through polymerase chain reaction (PCR). The 13A and 13B primers were used to perform the PCR. From 107 samples analysed with ELISA, 71,02% were positive for Leishmania sp, and positive outcome of 91,56% was observed by PCR. The evidence of epidemiologic risk factors like, the presence of a circulating parasite and of vectors leads to the conclusion that Opossums might be included in the leishmaniasis transmission cycle in Bauru city.
Sakauchi, Dirce. « Desenvolvimento de um ensaio do tipo ELISA indireto utilizando anti-soro policlonal produzido em coelho contra a proteína SP-A suína para quantificar SP-A no lavado broncoalveolar humano ». Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06012009-152702/.
Texte intégralThe lung collectins SP-A and SP-D are specific markers for lung diseases. Determination of amounts of these proteins using polyclonal and monoclonal antibodies on ELISA assays enabled clinicians to predict their role in the course of the lung disease process based on abnormalities on their concentrations. As the bronchoalveolar lavage (BAL) is a sample that permits to study the proteins secreted by the lung epithelium at any conditions, we proposed to develop an indirect ELISA able to detect SP-A in the BAL using polyclonal rabbit antiserum, raised against porcine SP-A. Porcine SP-A was purified by a protocol that includes an acid precipitation of the porcine pulmonary extract before affinity chromatography. The antiserum reacted with the two tested species porcine and human. The calibration curve were optimized, using human SP-A purified from patients with rheumatoid arthritis as human antigen calibrator. The selected calibration curve range was 0.312 to 5.0 mg/mL using the antiboby dilution 1:1.000. The detection limit of the standard curve was 0.625 mg/mL.
SIXDENIER, FABIENNE. « Detection de cryptospordium sp. Dans les selles de sideens : comparaison de trois methodes elisa avec la coloration de ziehl-neelsen modifiee et une technique d'immunofluorescence directe ». Lyon 1, 1993. http://www.theses.fr/1993LYO1M341.
Texte intégralOliveira, Carlos Augusto Fernandes de. « Aflatoxina M1 em leite em pó distribuído pelo Programa de Alimentação Escolar do Município de São Paulo, SP-Brasil : utilização do ensaio por enzimas imuno-adsorvidas (ELISA) ». Universidade de São Paulo, 1994. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-24012018-111852/.
Texte intégralAflatoxin M1 (AFM1) was surveyed in 300 samples of milk powder distributed by the School Food Supply Program of São Paulo, SP-Brazil. The analysis were performed by commercially available test sistems of competitive enzyme-linked immunosorbent assay (ELISA). Samples were reconstituted in water (1:8) and submitted directly to the assay, without clean-up procedures. Results showed 72 (24.0per cent ) positive samples for AFM1 at levels of 0.01 - 1.00 ng/ml (mean: 0.15 ng/ml). Concentrations above 0.10 ng/ml were observed in-33 samples (11.0per cent ). The method performance was evaluated experimentally in the laboratory, through repeated analysis of milk samples spiked with the toxin. Recoveries of AFM1 added to milk at levels of 0.10, 0.20, 0.50 and 1.00 ng/ml were 83.0per cent , 87.5per cent , 103.0per cent and 111.8per cent , respectively. Relative standard deviations for the concentrations refered were 65.5per cent , 31.8per cent , 10.9per cent and 13.6per cent , respectively (n = 10, per spiking level). By using data on milk consumption patterns, adopted by the Program for children aging 4 months (highest intake), a mean daily intake of 3.7 ng of AFM1/kg body weight/day was estimated. The implications of these data on human health, as well as the approaches for the establishment of regulations for AFM1 in milk and milk products, are discussed.
Rossi, Claudio Nazaretian [UNESP]. « Ocorrência de Leishmania sp. em gatos do município de Araçatuba - São Paulo - Brasil ». Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/89230.
Texte intégralFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Apesar de alguns relatos da ocorrência de leishmaniose visceral em felinos, a literatura é escassa no que diz respeito à sua pesquisa em populações de gatos de áreas endêmicas para a doença. Desta forma, o presente estudo teve por objetivo pesquisar em uma área endêmica para leishmaniose visceral canina, a possibilidade de infecção em gatos, por meio de exame parasitológico direto e da pesquisa de anticorpos anti-Leishmania chagasi pelas técnicas de ensaio imunoenzimático indireto (ELISA) e reação de imunofluorescência indireta (RIFI). Para tanto, foram colhidas amostras de soro de 200 gatos, encaminhados ao Centro de Controle de Zoonoses do município de Araçatuba - São Paulo - Brasil, bem como realizadas punções biópsias aspirativas de linfonodo, medula óssea, baço e fígado, utilizados para a confecção de preparados citológicos para a pesquisa direta de formas amastigotas de Leishmania sp. A prevalência da doença nessa população de gatos foi de 6,5%. Dos 200 animais avaliados, oito (4,0%) apresentaram resultado parasitológico positivo, seis (3,0%) apresentaram títulos sorológicos acima do ponto de corte (0,332) pela técnica de ELlSA e um (0,5%) evidenciou título superior ao ponto de corte (1:40) pela RIFI, totalizando 13 gatos considerados positivos.
In spite of some reports of the occurrence of feline visceral leishmaniasis, the literature is scarce about its research on populations of cats in endemic areas for the disease. The present work aimed to study, in an endemic area for canine visceral leishmaniasis, the infection possibility in cats using the direct parasitological test, enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescent antibody test (IFAT). For this purpose, a total of 200 cats directed to the Zoonosis Control Center of the municipal district of Araçatuba - São Paulo - Brazil were employed. Lymph node, bone marrow, spleen and liver aspiration biopsies were carried out and observed under optical microscope to search for amastigote forms of the parasite and serum samples were submitted to serological methods in order to detect anti-Leishmania chagasi circulating antibodies. The prevalence of the disease in this population of cats was 6.5%. Amastigote forms of the parasite were observed in eight (4.0%) cats; by ELISA method, six (3.0%) cats presented titer above the specie's cut off point (0,332) and one cat (0,5%) showed a titer above 1:40, a positive serological reaction, by IFAT, totalizing 13 positive cats.
Triques, Nelise Juliane. « Detecção de anticorpos contra Salmonella sp. em suco de carnes de suínos ». reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/13949.
Texte intégralSilva, Fabio Jorge Moreira da. « Rela??o entre infesta??o natural por Rhipicephalus (Boophilus) microplus (Acari : Ixodidae) e n?veis de anticorpos da classe IgG para os agentes da Tristeza Parasit?ria Bovina e Borrelia sp. em bezerros ». Universidade Federal Rural do Rio de Janeiro, 2008. https://tede.ufrrj.br/jspui/handle/tede/755.
Texte intégralConselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico
This study was conducted with the objective to contribute with the agreement of the relation calves x ticks x hemoparasites in the sector of milk cows of the Farm of the Institute of Zootecnia (FAIZ) of the Universidade Federal Rural do Rio de Janeiro (UFRRJ). Seventeen female calves with age between 15 days old and 14 months old, between july of 2006 and june of 2007. These animals were subdivided in three ages bands: up to 2 months, between 3- 6 months and above of 7 months, in accordance with the handling of the property. Was realized ticks`s counting, collection of blood and hematological examination of all the animals in interval of 14 days. The exams were carrying through in laboratories of Parasites Diseases, Clinical Pathology of UFRRJ and the Serological of Embrapa Beef Cattle. Throughout 12 months, it can be verified the constant presence of larvaes, nymphs and females of tick Rhipicephalus (Boophilus) microplus. The frequency of positive animals for the indirect enzyme-linked immunosorbent assay (ELISA), for the agents of the Tick-borne Disease (Babesia bigemina, B. bovis and Anaplasma marginale) and Borrelia sp., was verified that in all ages bands exist positive serological animal. The frequency and antibody levels, as much for B. bigemina as for B. bovis, evaluated through the indirect ELISA, had been high. This fact associated with the absence of infection symptoms suggests a situation of immunization of the animals and an area of enzootically stable. None trend of seasonal distribution of infections for B. bigemina, B. bovis, A. marginale and Borrelia sp. was observed.
Este estudo foi conduzido com o objetivo de contribuir para o entendimento das rela??es bezerros x carrapatos x hemoparasitos no setor de bovinocultura de leite da Fazenda do Instituto de Zootecnia (FAIZ) da Universidade Federal Rural do Rio de Janeiro (UFRRJ). Foram utilizadas 17 bezerras com idade entre 15 dias e 14 meses, entre julho de 2006 a junho de 2007. Estes animais foram subdivididos em tr?s faixas et?rias: at? 2 meses, de 3-6 meses e acima de 7 meses, de acordo com o manejo zoot?cnico da propriedade. Procedeu-se contagem de carrapatos, coleta de sangue e exames hematol?gicos de todos animais em intervalo de 14 dias. Os exames foram realizados nos Laborat?rios de Doen?as Parasit?rias, de Patologia Cl?nica da UFRRJ e de Sorologia da Embrapa Gado de Corte. Ao longo de 12 meses, podese verificar a presen?a constante de larvas, ninfas e f?meas de carrapatos Rhipicephalus (Boophilus) microplus. Em rela??o a freq??ncia de positividade pelo ensaio de imunoadsors?o enzim?tica (ELISA) indireto, para os agentes da Tristeza Parasit?ria Bovina (Babesia bigemina, B. bovis e Anaplasma marginale) e Borrelia sp., verificou-se que em todas as faixas et?rias haviam animais sorologicamente positivos. A freq??ncia e os n?veis de anticorpos, tanto para B. bigemina como para B. bovis, avaliados atrav?s do ELISA indireto, foram altos. Este fato associado ? aus?ncia de sintomas de infec??o sugere uma situa??o de pr?-imuniza??o dos animais e uma ?rea de estabilidade enzo?tica. N?o foi observada qualquer tend?ncia de distribui??o sazonal de infec??es por B. bigemina, B. bovis, Anaplasma marginale e Borrelia sp.
Cordeiro, Daniela. « Uso de bioindicador de efeito endócrino e validação do método para determinação de hormônios na água da Represa Municipal de São José do Rio Preto, SP ». Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-11032010-102102/.
Texte intégralAmong the several xenobiotics that human activities have produced in the last decades, endocrine disruptors (EDs), including hormones, have been drawing the attention of researches due to the effects they can cause in animals. Those effects may result in hermaphrodite characteristics in fishes and amphibians, testicular growth inhibition, spermatogenesis inhibition, eggs fertilization capacity decrease, and changes in the reproductive behavior of living beings. Concentrations of only 10 ng L-1 of hormones in the aquatic medium are capable of causing endocrine effects in organisms. In this study, the natural hormone 17β-estradiol and the synthetic ones levonorgestrel and 17α-ethinylestradiol were determined in the waters of the São José do Rio Preto (SP) dam. The first step of this study was the validation of the methods according to ANVISA\'s Resolution 899. The detection, quantification, and lower quantification limits of the method for determining 17α-ethinylestradiol were, respectively, 25, 100, and 100 ng L-1. The linearity, relative standard deviation, accuracy, and average recovery of the method for determining 17α-ethinylestradiol were, respectively, R equal to 0.98, 3.23%, 100.53%, and 89.95%. The detection, quantification, and lower quantification limits of the method for determining 17β-estradiol were, respectively, 100, 150, and 150 ng L-1. The linearity, relative standard deviation, accuracy, and average recovery of the method for determining 17β-estradiol were, respectively, R equal to 0.99, 3.43%, 106.16%, and 89.05%. For levonorgestrel, the detection, quantification, and lower quantification limits of the method were, respectively, 50, 150, and 150 ng L-1. The linearity, relative standard deviation, accuracy, and average recovery of the method for determining levonorgestrel were, respectively, R equal to 0.98, 3.48%, 105.15%, and 86.45%. In the second step of this research, samples collected in the São José do Rio Preto (SP) dam were analyzed regarding the presence of hormones. For extracting the hormones, SPE cartridges were used followed by HPLC/FLU/DAD. The results indicated the absence of the studied hormones down to the detection limits of the methods employed. Vitellogenin (VTG) analyses were performed in the blood plasma of fishes captured in the beforementioned dam, of the species Geophagus brasiliensis (pearl cichlid or pearl eartheater), Satanoperca pappaterra (Pantanal eartheater or Paraguay River eartheater), and Tilapia rendalli (redbreast tilapia). It was observed that male fishes had VTG concentrations between 152.4 and 2,841.8 ng mL-1. That indicates that there are substances with endocrine effect in the dam water, although one cannot say the studied hormones are among them.
Chapitres de livres sur le sujet "SP-ELISA"
Dilger, I., G. Schwedler, S. Janßen et J. W. Dudenhausen. « Messung der hydrophoben Surfactant-Proteine SP-B und SP-C im Fruchtwasser mit einem Kompetitions-ELISA als Beitrag zur antenatalen Lungenreifediagnostik ». Dans Gynäkologie und Geburtshilfe 1992, 1451–52. Berlin, Heidelberg : Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77857-5_581.
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