Thèses sur le sujet « SMCR8 »
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Pietri, David. « Structure and function of the C9ORF72-SMCR8-WDR41 complex and its implication for Amyotrophic Lateral Sclerosis (ALS) ». Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAJ087.
Texte intégralAmyotrophic lateral sclerosis (ALS or Charcot disease) is the third most common neurodegenerative disease. The main genetic cause of ALS is an expansion of GGGGCC repeats in the C9ORF72 gene which protein forms a complex with the SMCR8 and WDR41 proteins. To better understand its molecular functions, solving its structure was a main goal of my thesis. In parallel, we discovered that C9ORF72 regulates a newly described mechanism of biogenesis of newly-formed lysosomes, called autophagic lysosome reformation (ALR). This process has been extensively investigated during my thesis, in order to better understand its regulation, particularly for the regeneration of lysosomes in basal conditions and amino acid deprivation. My work reveals a new partner of the C9ORF72 complex as a novel function in lysosome biogenesis. These results could thus explain the dysfunction of lysosomes and neurodegeneration observed in ALS, which open new therapeutic ways for this devastating disease
O'Donohue, Daniel J. « First-term retention of enlisted Selected Marine Corps (SMCR) Reservists ». Thesis, Monterey, California. Naval Postgraduate School, 1988. http://hdl.handle.net/10945/23233.
Texte intégralLicari, Anthony D. « DEVELOPING A MARKOV MODEL FOR FORECASTING END STRENGTH OF SELECTED MARINE CORPS RESERVE (SMCR) OFFICERS ». Monterey, California. Naval Postgraduate School, 2013. http://hdl.handle.net/10945/32856.
Texte intégralConley, Gary D. « Examining the Cover and Composition of the Successional Vegetation Mosaic of Pre-SMCRA Mined Landscapes in Southeast Ohio ». Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1357751096.
Texte intégralHolsinger, John Frederick. « The Impact of SMCRA on Select Soil Properties in Reclaimed Mine Sites Determined by Geochemical and Hydrological Analyses ». The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406134738.
Texte intégralLeveroos, Maura K. « Economic Viability of Woody Bioenergy Cropping for Surface Mine Reclamation ». Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/50950.
Texte intégralMaster of Science
Prichard, Elizabeth Dulaney. « Sustainable Community Development in Boom and Bust Economies : A Comparative Case Analysis of Institutional Stakeholder Interaction in Four Appalachian Natural Resource Dependent Locales ». Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/99286.
Texte intégralPHD
Erhardt, Bruce J. Jr. « Development of a Markov Model for Forecasting Continuation Rates for Enlisted Prior Service and Non-Prior Service Personnel in the Selective Marine Corps Reserve (SMCR) ». Thesis, Monterey, California. Naval Postgraduate School, 2012. http://hdl.handle.net/10945/6791.
Texte intégralPennington, Michael Sean. « Is the coal industry worth protecting ? an examination of the effects of competing advocacy coalitions on implementation of the Surface Mining Control and Reclamation Act (SMCRA) of 1977 ». Texas A&M University, 2008. http://hdl.handle.net/1969.1/85961.
Texte intégralPollock, Matthew John. « Geomorphic Differences between Unmined and Surface Mined Lands in Southeastern Ohio ». The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429613137.
Texte intégralRuhm, Catherine Terese. « The Effects of Two Types of Reclamation on Abandoned Non-Coal Surface Mines in Cuyahoga Valley National Park, Ohio ». Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1543876471411951.
Texte intégralBack, Michael Patrick. « Working Backwards : Enhancing Forest Restoration by Reversing Effects of Surface Mine Reclamation on Soil Bulk Density and Soil Chemistry ». Kent State University Honors College / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors162014875138985.
Texte intégralJonsson, Peder. « Kommunikationsmodeller inom public relations ». Doctoral thesis, KTH, Industriell ekonomi och organisation (Inst.), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-205887.
Texte intégralQC 20170426
Gumbel, John D. « An evaluation of the Selected Reserve Educational Assistance Program (SREAP) as it relates to the Selected Marine Corps Reserve (SMCR) ». Thesis, 1987. http://hdl.handle.net/10945/22788.
Texte intégralChang, Lih-Yun, et 張力云. « Involvement of an inverted repeats in promoter of Vibrio vulnificus protease gene, vvp, in binding with SmcR and vvp expression ». Thesis, 2005. http://ndltd.ncl.edu.tw/handle/40070838247791346840.
Texte intégral國立成功大學
微生物暨免疫學研究所
93
Abstract We have found previously that SmcR, a transcriptional activator, is involved in the regulation of the metalloprotease (vvp) and cytolysin genes in Vibrio vulnificus, a marine bacterium causing wound infections and fatal septicemia. The putative SmcR-binding site in the vvp promoter region has been identified by DNase I footprint analysis, in which an inverted repeat sequence with a spacer of 14 bp was found. To determine the involvement of this inverted repeat region in binding with SmcR and transcriptional activation of vvp, seven point mutations at different positions in this region were created. The promoter mutations together with a downstream lacZ gene (Pvvp-lacZ) that served as the reporter were cloned individually into a suicide plasmid and subsequently introduced into V. vulnificus chromosome via homologous recombination between the lacZ gene in the plasmid and that in the chromosome. By assaying the -galactosidase activity in these strains, we found that four mutations that were located in the inverted repeats resulted in significant decreases in vvp promoter activity. However, another mutation in the inverted repeat and two mutations in the spacer did not affect the vvp promoter activity. We further examined the binding of SmcR to vvp promoter with the various mutations in this region by electrophoresis motive shift assay (EMSA). There was little difference between the wild type vvp promoter and the mutated ones, even those showing reduced vvp promoter activity, in binding with SmcR. One explanation for this inconsistency is that other factors may be involved in binding with vvp promoter region and regulation of vvp expression. On the other hand, the amino acid sequence from residues 39 to 59 of SmcR showed significant homology to the helix turn helix (HTH) DNA-binding domains of LuxR family. To determine the role of this putative HTH domain in binding with vvp promoter, five SmcR mutants were generated. Surprisingly, when expressed from a plasmid in the strain with a Pvvp-lacZ fusion, SmcR devoid of the HTH domain, namely, SmcR63-205 and SmcR101-205, retained the ability to activate the vvp promoter. On the contrary, those containing the HTH domain, SmcR29-205 and SmcR1-99, did not activate the vvp promoter. Furthermore, when combined with the various vvp promoter mutations, the -galactosidase expression patterns of SmcR63-205 were similar to those of the intact SmcR. However, for some reason not clear at this moment, the -galactosidase expression levels of the various vvp promoter mutants were similar to one another in the presence of SmcR101-205. We further examined the binding of SmcR63-205 to the vvp promoter with the various mutations by EMSA, and found that just like the intact SmcR, it bound to all the mutated promoter sequences. These results suggest that the SmcR C-terminal domain may be more important than the HTH domain for binding with and activation of vvp promoter.
Wu, Sin-Syuan, et 吳昕玹. « Studies on the Effect of Capsular Polysaccharides on Formation of Biofilm and Expression of Quorum-sensing Regulators LuxR/SmcR in Vibrio vulnificus ». Thesis, 2013. http://ndltd.ncl.edu.tw/handle/21810891370752940076.
Texte intégral輔英科技大學
醫學檢驗生物技術系碩士班
101
Vibrio vulnificus is a halophilic gram-negative bacterial species. In nature, V. vulnificus is present in marine environment and causes opportunistic infections in humans including septicemia and wound infection. The capsular polysaccharide is one of potential virulence factors and associated with formation of biofilm. To understand the effect of capsular polysaccharide on the formation of biofilm, this study uses the acapsular strain JF046 (ΔORFVV0364) with a mutation in capsular polysaccharide surface factor. The characteristics of bacterial growth and formation of biofilm were analyzed between strains. Furthermore, the mRNA expression of quorum-sensing regulators including LuxR and SmcR were determined and compared. First, the colony of YJ016 appeared to be opaque and JF046 was translucent. Second, the results of growth curve indicated that the bacterial density for growth (A600) were lower in JF046 than those in YJ016 both in seawater environment (cultured for 24 hours, 1.795 for YJ016, 1.486 for JF046; p=0.006) and fresh water environment (cultured for 24 hours, 1.519 for YJ016, 1.141 for JF046; p=0.005), respectively. Third, the bacterial aggregates were existed in JF046 and absent in YJ016. Fourth, the ability for formations of biofilm (A492/A620) in acapsular mutant JF046 were higher than those in wild type YJ016 both in seawater environment (0.91±0.15 for YJ016, 1.50±0.23 for JF046; p=0.047) and fresh water (0.50±0.05 for YJ016, 1.26±0.20 for JF046; p=0.013). Fifth, the expressions of quorum-sensing regulators, LuxR and SmcR, were compared between JF046 and YJ016. The results form regression analysis revealed that the correlation between mRNA expressions of LuxR and SmcR were r2=0.885 (y=1.045x+7.798) in YJ016 and r2=0.798 (y=0.928x+25.835) in JF046, respectively. In conclusion, the results demonstrated that the ORFVV0364 for capsular polysaccharide surface factor of Vibrio vulnificus is associated with formation of biofilm and quorum-sensing regulators expression.