Thèses sur le sujet « SMC Method »
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GONZATO, LUCA. « Application of Sequential Monte Carlo Methods to Dynamic Asset Pricing Models ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/295144.
Texte intégralIn this thesis we consider the application of Sequential Monte Carlo (SMC) methods to continuous-time asset pricing models. The first chapter of the thesis gives a self-contained overview on SMC methods. In particular, starting from basic Monte Carlo techniques we move to recent state of the art SMC algorithms. In the second chapter we review existing methods for the exact simulation of Hawkes processes. From our analysis we infer that the simulation scheme of Dassios and Zaho (2013) outperforms the other algorithms, including the most popular thinning method proposed by Ogata (1980). This chapter serves also as introduction to self-exciting jump processes, which are the subject of Chapter 3. Hence, in the third chapter we propose a new self-exciting jump diffusion model in order to describe oil price dynamics. We estimate the model by applying a state of the art SMC sampler on both spot and futures data. From the estimation results we find evidence of self-excitation in the oil market, which leads to an improved fit and a better out of sample futures forecasting performance with respect to jump-diffusion models with constant intensity. Furthermore, we compute and discuss two optimal hedging strategies based on futures trading. The optimality of the first hedging strategy proposed is based on the variance minimization, while the second strategy takes into account also the third-order moment contribution in considering the investors attitudes. A comparison between the two strategies in terms of hedging effectiveness is provided. Finally, in the fourth chapter we consider the estimation of continuous-time Wishart stochastic volatility models by observing portfolios of weighted options as in Orlowski (2019). In this framework we don't know the likelihood in closed-form; then we aim to estimate it using SMC techniques. To this end, we marginalize latent states and perform marginal likelihood estimation by adapting the recently proposed controlled SMC algorithm (Heng et. Al. 2019). From the numerical experiments we show that the proposed methodology gives much better results with respect to standard filtering techniques. Therefore, the great stability of our SMC method opens the door for effective joint estimation of latent states and unknown parameters in a Bayesian fashion. This last step amounts to design an SMC sampler based on a pseudo-marginal argument and is currently under preparation.
Esteras, Bejar Miguel. « Development of methods for the study of the role of the Smc5-Smc6 complex in DNA stability ». Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11072.
Texte intégralMcFarland, James. « Investigation of carbon nanotube growth using a nozzle CVD method ». Pomona College, 2006. http://ccdl.libraries.claremont.edu/u?/stc,4.
Texte intégralStrapko, Jaroslav. « Měření teplotních profilů SMD pouzder ». Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2010. http://www.nusl.cz/ntk/nusl-218369.
Texte intégralWang, Shu. « Thermodynamic properties predictions using the COSMO-SAC solvation method ». Access to citation, abstract and download form provided by ProQuest Information and Learning Company ; downloadable PDF file, 366 p, 2007. http://proquest.umi.com/pqdweb?did=1362532041&sid=24&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Texte intégralInoue, Shinichiro. « Ion assisted methods of deposition of SiC ». Thesis, University of Salford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308174.
Texte intégralZhang, Yixia. « Refined non-conforming linear and nonlinear finte [sic] element analysis ». Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22753060.
Texte intégralSaarikko, Jukka Olavi. « A multi-method empirical study of the Finnish SME restructurings ». Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500475.
Texte intégralYang, James J. « A statistical method for identifying informative genes in micorarrays [sic] ». [Gainesville, Fla.] : University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE1001199.
Texte intégralZhang, Yixia, et 張義霞. « Refined non-conforming linear and nonlinear finte [sic] element analysis ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31242704.
Texte intégralRoberts, Adam E. « A Phan-type theorem for orthgonal [sic] groups ». Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=bgsu1124723065.
Texte intégralPringle, Matthew. « Fnite [sic] element modelling of two-component, solid-liquid mixtures / ». *McMaster only, 2001.
Trouver le texte intégralCarballo, Jose M. « Residual Stress Analysis in 3C-SiC Thin Films by Substrate Curvature Method ». Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1590.
Texte intégralAngioni, Margherita. « The Role of the Internet in the Process of Internationalization of SMEs : A Mixed Method Analysis on the Furniture Sector ». Doctoral thesis, Urbino, 2019. http://hdl.handle.net/11576/2663935.
Texte intégralCabrera, Carlos Andres Cuenca. « Ductile failure prediction using phenomenological fracture model for steels : calibration, validation and application ». Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/3/3135/tde-27082018-075853/.
Texte intégralA presente dissertação apresenta o processo de análise, calibração e aplicação das propriedades mecânicas, incluindo o comportamento elastoplástico e de dano, para o aço A285, utilizando o critério \"Stress modified criticai strain\" (SMCS). Para obter o comportamento mecânico do material, testes experimentais foram realizados com a implementação de 5 tipos diferentes de geometrias: barra cilíndrica sem entalhe, barra cilíndrica com entalhe (R = 1, 2, 3 mm) e corpos de prova SE(B) com trinca inicial profunda e rasa. Para o processo de calibração das propriedades mecânicas foram gerados modelos de elementos finitos, utilizando elementos sólidos 30 com 8 nós (C3D8), que representam de forma adequada a geometria e as propriedades dos corpos de prova testados. Para calibrar o comportamento elastoplástico e iniciação do dano, utilizou-se a resposta experimental e numérica obtida para as amostras de barra cilíndrica com e sem entalhe; e, para a calibração da evolução do dano, foram utilizadas as respostas obtidas para os espécimes SEB de trincas profundas e rasa. Este modelo calibrado foi capaz de recuperar as respostas experimentais dos corpos de prova SE(B), o que valida o uso do material caracterizado em uma estrutura complexa. Uma vez calibradas as propriedades mecânicas, foram obtidos os fatores do critério SMSC representados pela equação ....... , e, a condição de dano que é representada pelo deslocamento na falha .... e o fator de amolecimento exponencial .... . Depois, o material totalmente caracterizado foi aplicado em dois dutos que possuem trinca elíptica circunferencial inicial externa; sendo o primeiro tubo com trinca superficial e o segundo com trinca profunda. Finalmente, ambos os tubos foram submetidos a cargas de tensão para prever o comportamento do dano dúctil, obtendo a carga necessária para o início do crescimento da trinca e a evolução da falha.
Benassi, Romain. « Nouvel algorithme d'optimisation bayésien utilisant une approche Monte-Carlo séquentielle ». Phd thesis, Supélec, 2013. http://tel.archives-ouvertes.fr/tel-00864700.
Texte intégralEsguerra, Mark. « An investigtion [sic] of developmentally appropriate methods in teaching drawing ». [Denver, Colo.] : Regis University, 2006. http://165.236.235.140/lib/MEsguerra2007.pdf.
Texte intégralWorley, Joseph Charles. « Equipping pastors to vary their their [sic] methods of preaching ». Theological Research Exchange Network (TREN), 1995. http://www.tren.com.
Texte intégralIslas, Michael E. « Efficiency improvement techniques for high voltage capacitor carging [sic] methods ». Orlando, Fla. : University of Central Florida, 2009. http://purl.fcla.edu/fcla/etd/CFE0002899.
Texte intégralSlavětínský, Radek. « Analýza cloudových řešení Business Intelligence pro SME ». Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-358847.
Texte intégralZhang, Jing. « The correlation among three hand srength [sic] measurement methods : hand dynamometer ». Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1020143.
Texte intégralSchool of Physical Education
Poskovic, Emir. « Innovative magnetic materials for the new applications in electrical machines ». Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3424784.
Texte intégralČedo, Žlebič. « Uticaj jednosmerne struje na karakteristike podešljivih feritnih komponenti ». Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110180&source=NDLTD&language=en.
Texte intégralAs part of this thesis variable ferite components with cores produced from comercialy available ESL 40011 ferite tapes manufactured in Low Temperature Co-fired Ceramic technology are implemented. Inductivity of the components is varied by applying DC current. Functionality of the implemented ferite components is verified in a circuit of DC-DC boost converter. This thesis proposes a measurement method which enables examining the influence of DC current on the characteristics of SMD inductors in real environment. The method is verified on comercialy available SMD inductors
Wiskel, J. Barry. « A study of the manufacturing method and related mechanical properties of SiC reinforced aluminum ». Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26343.
Texte intégralApplied Science, Faculty of
Materials Engineering, Department of
Graduate
Afrifa, Godfred Adjapong. « Working capital management and AIM listed SME companies profitability : a mixed research method approach ». Thesis, Bournemouth University, 2013. http://eprints.bournemouth.ac.uk/20968/.
Texte intégralArmour, Arthur David 1964. « Adaptive random search evaluated as a method for calibration of the SMA-NWSFS model ». Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/278394.
Texte intégralPutaala, J. (Jussi). « Reliability and prognostic monitoring methods of electronics interconnections in advanced SMD applications ». Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207605.
Texte intégralTiivistelmä Elektroniikkaliitosten rikkoontumisen seurantaan tarkoitettuja sähköisiä monitorointimenetelmiä kehitettiin samanaikaisesti karakterisoimalla testauksella liitoksiin aikaansaatuja muutoksia optisesti, akustisella mikroskoopilla sekä röntgen- ja pyyhkäisyelektronimikroskoopeilla. Liitosten eliniän ennustamiseen soveltuva muokattu Engelmaierin malli kalibroitiin PCSB-liitosten elinikäennusteen tarkkuuden parantamiseksi. Tulosten perusteella useimmille tässä työssä käytetyille lyijyttömille (SAC387, SAC405, SAC-In) juotteille ja suuren termisen epäsovituksen (ΔCTE > 10 ppm/°C) rakenneyhdistelmille eliniät lämpösyklaustesteissä 0‒100 °C ja −40‒125 °C alueilla olivat riittävät ja haitallisimpien murtumien, eli keraamimurtumien, määrä saatiin minimoiduksi. RF-mittauksia käytettiin liitosten vikaantumisen seurantaan sekä lämpösyklauksen aikana että syklausten välillä. Maadoitettua koplanaarista aaltojohtoa käytettiin joko suoraan perättäiskytkennässä tai suodatinmoduulin kanssa, jonka päästökaista oli 22–24 GHz. Rakenteet karakterisoitiin syklausten välillä 25 GHz ja 30 GHz asti tässä järjestyksessä. Näiden mittausten lisäksi 10–11 GHz kaistalla toimivaa antennirakennetta karakterisoitiin syklauksen aikana 14 GHz asti. Tulokset osoittavat, että signaalivasteen muutos ilmenee aluksi joillakin taajuuksilla lyhyinä, alle 1 s mittaisina häiriöpiikkeinä, 0‒100 °C syklauksen aikana. Syklauksen edetessä vasteen huononeminen havaitaan myöhemmin koko mittausalueella. Puolikokeellista elinikäennustemallia tarkasteltaessa havaittiin, että PCSB-liitosten lämpötila-alueesta riippuvia korjauskertoimia kuvasivat logaritmisen riippuvuuden sijaan parhaiten toisen asteen polynomifunktiot. PCSB BGA ‒rakenteille saadun ennusteen ja toteutuneen eliniän välinen ero oli pienimmillään alle 0.5 %
Santesmasses, Ruiz Didac 1978. « Selenoproteins across the tree of life : Methods and applications ». Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/565634.
Texte intégralSelenocysteine is known as the 21st amino acid. Selenoproteins incorporate selenocysteine in response to specific UGA codons through a recoding mechanism, which present in the three domains of life, but not in all organisms. Standard gene prediction programs consider UGA only as stop, and selenoproteins are normally misannotated. We have developed computational methods for prediction of selenoproteins. By applying these and other tools, we have characterized selenoproteins across the Tree of Life, showing a diverse evolution of the utilization of selenocysteine in different lineages. We have characterized the abundance and distribution of selenoproteins in the human microbiota. We characterized the selenoproteins in Lokiarchaeota, which have some eukaryotic-like features. Finally we gave special attention to insects, in which a progressive reduction in the number of selenoproteins culminated in multiple independent selenoprotein extinctions.
Costa, Gonçalo José Rodrigues. « Experimental investigation of EDM parameters on machining AIMg10 15%SiC composite based on Taguchi method ». Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11347.
Texte intégralO objetivo do estudo é investigar os efeitos da corrente de pico, servo voltagem, pulso on-time e pulso off-time na perfuração por electroerosão da liga de Alumínio Magnésio reforçado com carbonetos de silício e determinar a sua influência num grupo de parâmetros de saída, que incluem a taxa de remoção de material, desgaste do elétrodo, sobre corte radial e conicidade. Para melhor entender o problema experimental e todas as questões que este inclui, em primeiro lugar, foi feita uma revisão da literatura que abrange todos os princípios, tecnologias e aplicações do processo de electroerosão. Os dados para esta pesquisa foram recolhidos no laboratório de tecnologias não convencionais na "Gheorghe Asachi" Universidade Técnica de Iasi. O design de experiencias foi escolhido através do metodo Taguchi, nomeadamente o array L9. O primeiro objetivo desta pesquisa é encontrar a combinação ideal dos níveis de parâmetros através do método de Taguchi. O segundo objetivo é encontrar a contribuição da cada parâmetro de entrada para cada parâmetro de saída usando o método de análise estatística Análise da Variância. Objetivo final é desenvolver um modelo matemático para prever os valores de saída experimentais, através do software GW-Basic. Os resultados mostraram que os parâmetros com uma maior influência sobre a taxa de remoção de material e desgaste dos elétrodos foram a servo voltagem e corrente de pico, com 49% e 24% em relação ao primeiro parâmetro e 84% e 10% em relação ao segundo. O sobre corte radial foi mais influenciado pela corrente de pico e pelo pulso on-time, com 29% e 35%. Relativamente a conicidade, os parâmetros com mais influência foram corrente de pico e o pulso on-time, com 47% e 33% em termos de contribuição. Além disso, os níveis de combinação ótima de parâmetros associadas com a taxa de remoção de material, desgaste dos elétrodos, sobre corte radial e conicidade foram também obtidos. As respostas em estudo podem ser previstas usando os modelos matemáticos com um erro médio de 2% para a taxa de remoção de material, 16% para o desgaste do elétrodo, de 2% para sobre corte radial e 2% para a conicidade.
The purpose of this study is to investigate the effects of peak current, servo voltage, pulse on− time and pulse off − time on electrical discharge drilling of an aluminum magnesium reinforced with particles of silicone carbide and determine their influence on a range of output parameters such as material removal ratio, electrodewear,radial over cut and taper. To better understand the experimental problem and all issues that it includes, firstly, was done a literature review that covers all the electrical discharge machining principals, technologies and applications.The data for this research was collected on the “non conventional“ machining technologies laboratory at “Gheorghe Asachi” Technical University of Iasi. The design of experiments was chosen by Taguchi method, namely, orthogonal array L9.The first goal of this research is to find the optimum parameter level combination through the Taguchi method. The second goal is to find the contribution of the each parameter for each output using the statistic method Analysis of variance. Final goal was to find a mathematical model to predict the experimental output values, through a software GW-Basic. The results shows that the parameters with more influence on material removal ratio and electrode wear responses were servo voltage and peak current, with 49% and 24% regarding the first output and 84% and 10% the second. Radial over cut was more influenced by peak current and pulse on-time, with 29% and 35%, concerning the taper, the parameters with more influence were also peak current and pulse on-time but with 47% and 33% of contribution. In addition, the optimal combination levels of machining parameters associated with material removal rate, electrode wear, radial over cut and taper were also drawn. Responses in study can be predicted using the Mathematical models with a average error of 2% for material removal rate, 16% for electrode wear, 2% for radial over cut and 2% for taper.
Savchenko, Dariya, Bela Shanina, E. Kalabukhova, Andreas Pöppl, J. Lancok et Evgeny Mokhov. « The spin relaxation of nitrogen donors in 6H SiC crystals as studied by the electron spin echo method ». AIP Publishing, 2016. https://ul.qucosa.de/id/qucosa%3A21289.
Texte intégralSimon, Tom. « Temperaturbestimmung an IGBTs und Dioden unter hohen Stoßstrombelastungen ». Master's thesis, Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-166595.
Texte intégralCalminder, Tobias, et Martin Carlshamre. « The Transition towards Product-Service Systems : A Business Development Method for Small and Medium-Sized Manufacturing Enterprisees ». Thesis, Linköping University, Department of Management and Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15656.
Texte intégralThe increasing competition on today’s globalized markets creates drivers for new business models in order to create competitive advantage. By integrating services with the physical product, unique offers that aim at fulfilling customer needs rather than just providing physical goods can be created. This type of offers, in the literature often referred to as Product-Service Systems (PSS), are more difficult to imitate than pure products. Furthermore, the focus on fulfilling customer needs rather than just providing physical goods can reduce the use of resources, decreasing both costs and the environmental impact of the offer. From the customers’ point of view, PSS offers can bring increased flexibility and reduced risk. The development of successful PSS offers requires structured methods. Much of the research within the area, and consequently models and guidelines, has focused on large companies. However, since small and medium-sized enterprises (SMEs) constitute the foundation of economic growth in all developed countries, there is an important gap in the existing research within this area. One research initiative to fill this gap is the ongoing IPSE project (Integrated Product and Service Engineering), which aims at developing a methodology for efficient development of PSS offers in manufacturing SMEs. The methodology developed in the IPSE project is however at a conceptual level that is not applicable for the management in smaller companies. This thesis hence aims at developing a concrete and useful business development method applicable for the management in manufacturing SMEs, with the focus on generation of PSS offer concepts.
Based on earlier research within the PSS area, with the emphasis on the IPSE methodology, a concrete business development method for the generation of PSS concepts was created, which was then tested on three SMEs in order to verify and improve the method. The method consists of the three steps internal analysis, external analysis and planning of the new PSS offer. Each step contains a number of tools to be used in order to analyze different aspects of the business context. After analyzing the studies of the three case studies a revised method was developed, which was then summarized in managerial guidelines to be used by managers in manufacturing SMEs. The revision of the method mainly regarded simplifications of some of the tools in order to ease the use and increase the applicability.
The method proved to be useful and concepts could be generated for all the case companies. The method thoroughly examined the possibilities of creating PSS offers, even though it was found that it was also useful for the development of conventional business offers. Since the drivers for the case companies were specific threats or opportunities that would require changes in the offer, rather than a purpose in itself to integrate more services in the offer, this implies that the method can be useful as general business development method for manufacturing SMEs.
An important learning from our studies is that the day-to-day business is strongly focused by the managers in manufacturing SMEs, leaving little time for long-term business development. As stated by a manager in the case companies:
“It is like running beside the bicycle, but we do not have the time to get on it.”
The developed method can work as a tool for structuring the information needed in the business development process and hence reducing the time needed. However, if the reduction in time needed for long-term business development is enough to get the managers on their bikes is a question assigned to further studies.
Guo, Yu-yau. « Behavioral modeling and simulaitons [sic] of mixed-signal integrated circuits with process variations and physical defects / ». View online ; access limited to URI, 2003. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3115630.
Texte intégralGause, L. Arnold. « An evaluation of the Columbia Ministry, Education, and Training Center (C-MET) an alternative method of theological education / ». Theological Research Exchange Network (TREN), 1993. http://www.tren.com.
Texte intégralDyckman, Theodore R. (Theodore Robert) 1978. « Benchmark characterization for reusable launch vehicle onboard trajectory generation using a Legendre psuedospectral [sic] optimization method ». Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/82221.
Texte intégralQuintanilla-Anicama, Mario, Johana Congona-Garcia, Edgardo Carvallo-Munar, Iliana Macassi-Jauregui et Luis Cardenas. « Combined method redesign for the packing area in a peruvian bakery sme provider of national food programs ». Springer, 2021. http://hdl.handle.net/10757/656013.
Texte intégralSimmons, Kate D. « Improving the spelling skills of elementary students with mild learning and behavior problems a comparison between an explict [sic] rule-based method and traditional method / ». Auburn, Ala., 2007. http://repo.lib.auburn.edu/07M%20Dissertations/SIMMONS_KATE_27.pdf.
Texte intégralvon, Axelson Jens. « On development of production methods for transfer to SMEs ». Doctoral thesis, KTH, Industriell produktion, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4502.
Texte intégralQC 20100729
Poller, Tilo. « Thermal and thermal-mechanical simulation for the prediction of fatigue processes in packages for power semiconductor devices ». Doctoral thesis, Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-154320.
Texte intégralFür die Entwicklung von Umrichtern ist die Kenntnis über die Zuverlässigkeit der Leistungselektronik ein wichtiges Kernthema. Insbesondere für Offshore-Anwendungen ist das Wissen über die stattfindenden Ermüdungsprozesse und die Abschätzung der zu erwartenden Lebensdauer der Bauteile essentiell. Hierfür hat sich die Simulation als ein wichtiges Werkzeug für die Entwicklung und Lebensdauerbewertung von leistungselektronischen Anlagen etabliert. In der folgenden Arbeit wird das thermische und das thermisch-mechanische Verhalten der Leistungselektronik mittels Simulationen untersucht. Hierzu wird ein Vergleich zwischen verschiedenen thermischen Modellen für Leistungsbauelemente durchgeführt. Schwerpunkt ist die Beschreibung der thermischen Kopplung zwischen den Chips und deren Einfluss auf die Lebensdauerabschätzung. Ein weiterer Schwerpunkt ist das Leistungsmodul, welches sich als ein Standardgehäuse etabliert hat. Dazu wird erklärt, wie die Variation der Einschaltzeit im aktiven Lastwechseltest den Fehlermodus dieses Gehäusetyps beeinflusst. Weiterhin wird untersucht, wie SiC als Leistungshalbleiter und DAB als Substrat die Zuverlässigkeit beein- flusst. Der Press-Pack ist für Hochleistungsapplikationen von hohem Interesse, da dieses Gehäuse im elektrischen Fehlerfall ohne äußere Unterstützung kurzschliesst. Jedoch ist das Wissen über diese Gehäusetechnologie unter aktiven Lastwechselbedingungen sehr limitiert. Mit Hilfe von Simulationen wird dieses Verhalten untersucht und mögliche Schwachpunkte abgeleitet. Am Ende der Arbeit werden Möglichkeiten untersucht, wie Mithilfe von FEM Simulationen die Lebensdauer von Leistungsmodulen evaluiert werden kann
Cho, Harngid. « Financing methods that drive innovation in biotech and pharmaceuticals : the meagfund [sic] IPO model ». Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90227.
Texte intégralTitle as it appears in the MIT commencement exercises program, June 6, 2014: Financing methods that drive innovation in biotechnology: the megafund IPO model Cataloged from PDF version of thesis.
Includes bibliographical references (pages 91-92).
Current research has shown that a mega fund and securitization approach using debt financing can not only mitigate risk in investments in cancer but can also align research and development in the right direction for new and innovative breakthrough therapies. We propose a new application of this megafund biopharma model - the megafund IPO model. There are almost arbitrage-like opportunities for investors where there are heavily discounted investments opportunities which are generated in IPO's. However, these events driven investments are only for the institutional investor and hence pooling capital into a more scalable mega fund structure could generate returns that are not otherwise possible while encouraging innovation in biomedicine. The investment vehicle is attractive to investors because of the significant amount of alpha that the fund can generate on de-risked basis. Risk is mitigated by the fact that there is an arbitrage like opportunity for the institutional investor in events driven investments for the mispricing of an IPO. We examine a back-testing of ten years examining a long only strategy and later also look at a case study of Monashee Investment Management that currently most closely resembles the megafund IPO model.
by Harngid Cho.
M. Fin.
Lind, Sofia. « Adaptation of eco-design methods for SMEs in India : Experiences from the electronics industry ». Thesis, Linköping University, Department of Water and Environmental Studies, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9195.
Texte intégralThis thesis presents guidelines for how eco-design methods can be adapted to facilitate the introduction of ecologically responsible manufacturing in small and medium sized enterprises (SMEs) in the Indian electronics industry. It also investigates the major opportunities and obstacles for eco-design to become a natural part of product design. This is urgent both from environmental and economic perspectives since the SMEs pollute a lot in proportion to their share of the total industrial production, and at the same time they are vulnerable for the increasing environmental demands on product design. The European Union recently introduced their directive on the Restriction of the Use of certain Hazardous Substances in Electrical and Electronic Equipment (RoHS) which bans certain hazardous chemicals in electric and electronic device. For many producers that supply to the European market this was a wake up clock to start thinking about environmental aspects related to production.
The study was carried out as an interview and questionnaire study at three SMEs in the electronics industry. Additional interviews were held with informants in different organisations. It was concluded that for SMEs in the Indian electronics industry qualitative and semi-quantitative eco-design methods should be chosen before quantitative methods. Eco-design methods should resemble traditional methods that are already used in the companies. For the product developers to be able to work with eco-design more education and other solutions are needed to raise the environmental knowledge. Support and commitment from top management is also imperative. Methods should be developed to encourage the establishment of multi functional teams and early integration of environmental aspects in design projects.
The external demands on environmentally responsible manufacturing are expected to increase in the future. This will most likely have a positive influence on the environmental awareness in the industry, just as the RoHS directive has had. However, there are still economic and technical barriers that need to be bridged for SMEs in India to be able to work with eco-design. More cooperation and communication between academics, policy makers and the industry is needed to make it happen.
Kapsalis, Alexandra, et Roy Khazzaka. « Införande av digitalt mätsystem i tillverkande SME företag : MeasurLink ». Thesis, KTH, Hållbar produktionsutveckling (ML), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-276685.
Texte intégralThe quality of products manufactured by SME companies is of high importance for their competitiveness. Being able to produce tailor-made items of high quality and being able to deliver on time and according to specification are some of the most common requirements large companies place as customers. Manufacturing SME companies differentiate themselves from competitors by digitalizing their processes. However, the need for digital tools can also be considered as a survival factor, as the demands of customers become higher the more automated customers' factories become. Switching to a digitalized quality assurance process for SMEs is not easy. Part of the problems associated with the transition to a digitalized quality assurance process is the lack of IT knowledge and the limited resources that SME companies have. The purpose of this bachelor’s thesis is to analyze the use of digital measuring tools that can be used in the quality assurance process in manufacturing SME companies. As well as to analyze how this implementation can be carried out in the best possible way. To achieve this goal, this thesis answered the following research questions: 1) What quality assurance processes do SME manufacturing companies currently use? 2) How can digital tools be implemented to assist the quality assurance process of manufacturing SMEs? 3) What are the challenges in implementing digital quality assurance tools in manufacturing SMEs? The thesis is based on theories of different quality assurance processes. Examples of these are Lean, TQM and Six Sigma. The method used was a case study at the company Marcus Komponenter AB in Järna outside Södertälje. In the case study, the digital measurement system MeasurLink provided by Mitotoyo was used to digitalize the quality assurance process of the manufactured products. The data collection has been carried out using three different qualitative data collection methods; document collection, interviews and observations. The result of the thesis shows that the company should follow an action plan so that they can prepare in order to be able to implement a digital measurement system full-scale throughout the production. The result is important because it shows that companies should have achieved a certain degree of maturity in order to be able to implement digital measurement systems. In summary, the conclusion of the case study was that a large-scale implementation of MeasurLink is currently not possible. However, the implementation can be done in a smaller scale, at a test station. Once the company has built up a standardized method of measurement and data analysis using MeasurLink, a full-scale implementation can be performed.
Gumprecht, Daniela. « Spatial Methods in Econometrics. An Application to R&D Spillovers ». Department of Statistics and Mathematics, WU Vienna University of Economics and Business, 2005. http://epub.wu.ac.at/290/1/document.pdf.
Texte intégralSeries: Research Report Series / Department of Statistics and Mathematics
Bernardin, Frederick E. « Application of Semi-Grand Canonical Monte Carlo (SGMC) methods to describe non-equilibrium polymer systems ». Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42428.
Texte intégralIncludes bibliographical references.
Understanding the structure of materials, and how this structure affects their properties, is an important step towards the understanding that is necessary in order to apply computational methods to the end of designing materials to fit very specific needs. Such needs include specific optical and mechanical properties. In polymers, the ability to easily create orientation through a variety of processes allows the production of materials that, while chemically similar, exhibit a wide variety of optical and mechanical properties. The ability to illuminate the connections between structure and optical or mechanical properties depends on the ability to reliably interpret a wide variety of experimental measurements. I assert that thermodynamic consistency and energy minimization is an integral part of this endeavor; reliable analyses of structure and properties are built upon the foundation of a minimum-free-energy ensemble of configurations that reproduces the experimental results. This project encompasses three goals, which make up this thesis: 1) to show how sets of experimental measurements are integrated into simulations to produce thermodynamically consistent, minimum-free-energy ensembles; 2) to show how these ensembles can characterize the conformations of macromolecules, which are not available from direct simulation; 3) to show how dynamic processes, which create inhomogeneous systems can be incorporated, along with experimental structural measurements, into thermodynamically consistent, minimum-free-energy ensembles. To achieve the first of these goals, we describe the application of the Semi-Grand Canonical Monte Carlo (SGMC) method to analyze and interpret experimental data for non-equilibrium polymer melts and glasses. Experiments that provide information about atomic-level ordering, e.g. birefringence, are amenable to this approach.
(cont.) Closure of the inverse problem of determining the structural detail from limited data is achieved by selecting the lowest-free-energy ensemble of configurations that reproduces the experimental data. The free energy is calculated using the thermodynamic potential of the appropriate semi-grand canonical (SGC) ensemble ... , as defined by the experimental data. To illustrate the method we examine uniaxially oriented polyethylene melts of average chain length up to C400. The simulation results are analyzed for features not explicitly measured by birefringence, such as the density, torsion angle distribution, molecular scale orientation and free energy, to understand more fully the underlying features of these non-equilibrium states. The stress-optical rule for polyethylene is evaluated in this way. The second goal is achieved through multi-scale modeling, which requires the selection and preservation of information crucial to understanding the behavior of a system at appropriate length and time scales. For a description of processed polymers, such a model must successfully link rheological properties with atomic-level structure. We propose a method for the calculation of an important rheological state descriptor, the configuration tensor
(cont.) Because the characteristic relaxation times of processed polymer chains often span several orders of magnitude, it is commonly the case that partial relaxation of the chains is frozen into the final product. We report results of molecular simulations by the Semi-grand Canonical Monte Carlo (SGMC) method to study the orientation-dependent elasticity of glassy polystyrene as a function of both the system-average degree of orientation and the degree of relaxation of chain ends at a constant average degree of orientation, in accord with the tube model of Doi and Edwards. Our simulations reproduce quantitatively the experimentally observed changes in the tensile modulus E33 as a function of both average orientation and inhomogeneity of the orientation due to partial relaxation. The results show that the partial relaxation of the polymer chains is sufficient to explain the observed variation of mechanical properties for samples that differ in processing history, yet have the same observed birefringence.
by Frederick E. Bernardin, III.
Ph.D.
Celik, Ertugrul. « Integrating EMS into SCM : A Case Study of Methods, Benefits and Barriers at Sandvik Tooling ». Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-21299.
Texte intégralZaidi, Mohammed. « Experimental Testing and Reliability Analysis of Repaired SMA and Steel Reinforced Shear Walls ». Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35357.
Texte intégralКраснов, В. А., С. Ю. Ерохин et А. Н. Деменский. « Формирование внутренних дефектов в p-n структурах SiC для перспективных источников одиночных фотонов ». Thesis, Сумский государственный университет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64503.
Texte intégralEnmark, Martin. « Fundamental Investigations of Supercritical Fluid Chromatography ». Doctoral thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-37913.
Texte intégralThis thesis aims at a deeper understanding of Supercritical Fluid Chromatography (SFC). Although preparative SFC has started to replace Liquid Chromatography (LC) in the pharmaceutical industry - because of its advantages in speed and its less environmental impact - fundamental understanding is still lacking. Therefore there is no rigid framework to characterize adsorption or to understand the impact of changes in operational conditions. In Paper I-II it was demonstrated why most methods applied to determine adsorption isotherms in LC could not be applied directly for SFC. Methods based on extracting data from overloaded profiles should be preferred. In Paper III a Design of Experiments approach was successfully used to quantitatively describe the behavior of several solutes in a separation system. This approach can be used to optimize SFC separations or to provide information about the separation system. In Paper IV severe peak distortion effects often observed in SFC were carefully investigated and explained using experiments and simulations. Finally, in Paper V, the prerequisites for performing reliable and predictable scale-up of SFC were investigated by small and large scale experiments.
Paper 4 ("Evaluation of scale-up from analytical to preparative...") ingick som manuskript med samma titel i avhandlingen. Nu publicerad.
Xu, Yingjie. « Prediction of properties and optimal design of microstructure of multi-phase and multi-layer C/SiC composites ». Phd thesis, Université de Technologie de Belfort-Montbeliard, 2011. http://tel.archives-ouvertes.fr/tel-00625953.
Texte intégralGao, Xiang. « Using methods of optimization programming and meta-analysis to evaluate current Unite [sic] States nutritional recommendations / ». Thesis, Connect to Dissertations & ; Theses @ Tufts University, 2005.
Trouver le texte intégralAdviser: Katherine L. Tucker. Submitted to the School of Nutrition Science and Policy. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;