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1
Single-molecule cellular biophysics. Cambridge : Cambridge University Press, 2012.
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Chemical cytometry : Ultrasensitive analysis of single cells. Weinheim : Wiley-VCH, 2010.
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Sako, Yasushi. Cell Signaling Reactions : Single-Molecular Kinetic Analysis. Dordrecht : Springer Science+Business Media B.V., 2011.
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Sardin, Marie-Neige. Celle qui dit non. Paris : Œuvre, 2011.
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1961-, Duijn Bert van, et Wiltink Anneke 1961-, dir. Signal transduction--single cell techniques. Berlin : Springer, 1998.
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The diversity of life : From single cells to multicellular organizations. Oxford : Heinemann Library, 2003.
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Snedden, Robert. The diversity of life : From single cells to multicellular organisms. Chicago, Ill : Heinemann Library, 2008.
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Arnaud, Chauvière, Preziosi Luigi et Verdier Claude 1962-, dir. Cell mechanics : From single scale-based models to multiscale modeling. Boca Raton : Chapman & Hall/CRC, 2009.
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Arnaud, Chauvière, Preziosi Luigi et Verdier Claude, dir. Cell mechanics : From single scale-based models to multiscale modeling. Boca Raton : Chapman & Hall/CRC, 2009.
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Luigi, Preziosi, et Verdier Claude, dir. Cell mechanics : From single scale-based models to multiscale modeling. Boca Raton : Chapman & Hall/CRC, 2009.
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Leake, Mark C. Single-Molecule Cellular Biophysics. Cambridge University Press, 2012.
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Leake, Mark C. Single-Molecule Cellular Biophysics. Cambridge University Press, 2013.
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Leake, Mark C. Single-Molecule Cellular Biophysics. Cambridge University Press, 2013.
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Stockings and Cellulite. Troubador Publishing Limited, 2010.
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Viggiano, Debbie. Stockings and Cellulite. Troubador Publishing Limited, 2010.
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Ueda, Masahiro, et Yasushi Sako. Cell Signaling Reactions : Single-Molecular Kinetic Analysis. Springer Netherlands, 2014.
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Jef ferys, John G. R. Cortical activity : single cell, cell assemblages, and networks. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199688395.003.0004.
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This chapter describes how the activity of neurons produces electrical potentials that can be recorded at the levels of single cells, small groups of neurons, and larger neuronal networks. It outlines how the movement of ions across neuronal membranes produces action potentials and synaptic potentials. It considers how the spatial arrangement of specific ion channels on the neuronal surface can produce potentials that can be recorded from the extracellular space. Finally, it outlines how the layered cellular structure of the neocortex can result in summation of signals from many neurons to be large enough to record through the scalp as evoked potentials or the electroencephalogram.
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Henderson, Daniel A., R. J. Boys, Carole J. Proctor et Darren J. Wilkinson. Linking systems biology models to data : A stochastic kinetic model of p53 oscillations. Sous la direction de Anthony O'Hagan et Mike West. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198703174.013.7.
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This article discusses the use of a stochastic kinetic model to study protein level oscillations in single living cancer cells, using the p53 and Mdm2 proteins as examples. It describes the refinement of a dynamic stochastic process model of the cellular response to DNA damage and compares this model to time course data on the levels of p53 and Mdm2. The article first provides a biological background on p53 and Mdm2 before explaining how the stochastic kinetic model is constructed. It then introduces the stochastic kinetic model and links it to the data and goes on to apply sophisticated MCMC methods to compute posterior distributions. The results demonstrate that it is possible to develop computationally intensive Markov chain Monte Carlo (MCMC) methods for conducting a Bayesian analysis of an intra-cellular stochastic systems biology model using single-cell time course data.
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Koch, Christof. Biophysics of Computation. Oxford University Press, 1998. http://dx.doi.org/10.1093/oso/9780195104912.001.0001.
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Neural network research often builds on the fiction that neurons are simple linear threshold units, completely neglecting the highly dynamic and complex nature of synapses, dendrites, and voltage-dependent ionic currents. Biophysics of Computation: Information Processing in Single Neurons challenges this notion, using richly detailed experimental and theoretical findings from cellular biophysics to explain the repertoire of computational functions available to single neurons. The author shows how individual nerve cells can multiply, integrate, or delay synaptic inputs and how information can be encoded in the voltage across the membrane, in the intracellular calcium concentration, or in the timing of individual spikes. Key topics covered include the linear cable equation; cable theory as applied to passive dendritic trees and dendritic spines; chemical and electrical synapses and how to treat them from a computational point of view; nonlinear interactions of synaptic input in passive and active dendritic trees; the Hodgkin-Huxley model of action potential generation and propagation; phase space analysis; linking stochastic ionic channels to membrane-dependent currents; calcium and potassium currents and their role in information processing; the role of diffusion, buffering and binding of calcium, and other messenger systems in information processing and storage; short- and long-term models of synaptic plasticity; simplified models of single cells; stochastic aspects of neuronal firing; the nature of the neuronal code; and unconventional models of sub-cellular computation. Biophysics of Computation: Information Processing in Single Neurons serves as an ideal text for advanced undergraduate and graduate courses in cellular biophysics, computational neuroscience, and neural networks, and will appeal to students and professionals in neuroscience, electrical and computer engineering, and physics.
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Snedden, Robert. Diversity of Life : From Single Cells to Multicellular Organisms. Capstone, 2007.
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Snedden, Robert. Diversity of Life : From Single Cells to Multicellular Organisms. Raintree Publishers, 2008.
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Diversity of Life : From Single Cells to Multicellular Organisms (Cells & Life). Heinemann, 2002.
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The Diversity of Life : From Single Cells to Multicellular Organisations (Cell & Life). Heinemann, 2002.
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Waves In Neural Media From Single Neurons To Neural Fields. Springer-Verlag New York Inc., 2013.
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Snedden, Robert. The Diversity of Life : From Single Cells to Multicellular Organisms (Cells and Life/ 2nd Edition). Heinemann, 2007.
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Snedden, Robert. The Diversity of Life : From Single Cells to Multicellular Organisms (Cells and Life/ 2nd Edition). Heinemann, 2007.
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Salgals, Toms. Development and Assessment of a Spectrally Efficient Hybrid Optical Communication Systems. RTU Press, 2022. http://dx.doi.org/10.7250/9789934228056.
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Thesis describes the wavelength division multiplexed fiber optic communication systems, i.e., assessment of the development of PON and DCI. Experimentally evaluate the application of spectrally efficient multi-level pulse amplitude modulation formats to increase the performance of PON, DCI and RoF solutions for 5G and beyond implementation. Application of SDM technology for the implementation of a spectrally and spatial efficient wavelength division multiplexed FOTS is evaluated. Spectrally efficient next-generation optical system for the transmission of millimeter-wave radio signals over fiber for cellular mobile communications and new hybrid fiber optic transmission system architecture capable of broadband Internet data transmission and radio signal transmission over single optical fiber was developed. Implementation of a novel type of transmission with a novel WGMR-based Kerr-OFC multi-wave light source are shown and presented for first time.
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Albert, Tyler J., et Erik R. Swenson. The blood cells and blood count. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0265.
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Blood is a dynamic fluid consisting of cellular and plasma components undergoing constant regeneration and recycling. Like most physiological systems, the concentrations of these components are tightly regulated within narrow limits under normal conditions. In the critically-ill population, however, haematological abnormalities frequently occur and are largely due to non-haematological single- or multiple-organ pathology. Haematopoiesis originates from the pluripotent stem cell, which undergoes replication, proliferation, and differentiation, giving rise to cells of the erythroid, myeloid, and lymphoid series, as well as megakaryocytes, the precursors to platelets. The haemostatic system is responsible for maintaining blood fluidity and, at the same time, prevents blood loss by initiating rapid, localized, and appropriate blood clotting at sites of vascular damage. This system is complex, comprising both cellular and plasma elements, i.e. platelets, coagulation and fibrinolytic cascades, the natural intrinsic and extrinsic pathways of anticoagulation, and the vascular endothelium. A rapid, reliable, and inexpensive method of examining haematological disorders is the peripheral blood smear, which allows practitioners to assess the functional status of the bone marrow during cytopenic states. Red blood cells, which are primarily concerned with oxygen and carbon dioxide transport, have a normal lifespan of only 120 days and require constant erythropoiesis. White blood cells represent a summation of several circulating cell types, each deriving from the hematopoietic stem cell, together forming the critical components of both the innate and adaptive immune systems. Platelets are integral to haemostasis, and also aid our inflammatory and immune responses, help maintain vascular integrity, and contribute to wound healing.
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Chess, Andrew, et Schahram Akbarian. The Human Brain and its Epigenomes. Sous la direction de Dennis S. Charney, Eric J. Nestler, Pamela Sklar et Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0003.
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Conventional psychopharmacology elicits an insufficient therapeutic response in more than one half of patients diagnosed with schizophrenia, bipolar disorder, depression, anxiety, or related disorders. This underscores the need to further explore the neurobiology and molecular pathology of mental disorders in order to develop novel treatment strategies of higher efficacy. One promising avenue of research is epigenetics.Deeper understanding of genome organization and function in normal and diseased human brain will require comprehensive charting of neuronal and glial epigenomes. This includes DNA cytosine and adenine methylation, hundred(s) of residue-specific post-translational histone modifications and histone variants, transcription factor occupancies, and chromosomal conformations and loopings. Epigenome mappings provide an important avenue to assign function to many risk-associated DNA variants and mutations that do not affect protein-coding sequences. Powerful novel single cell technologies offer the opportunity to understand genome function in context of the vastly complex cellular heterogeneity and neuroanatomical diversity of the human brain.
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Wilsey, Brian J. Biodiversity of Grasslands. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198744511.003.0002.
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Grasslands can be surprisingly diverse and contain many charismatic flora and fauna. Plant species are often combined into functional groups. Three major conceptual models: competitors-stress tolerants-ruderals (CSR); the leaf traits, plant height, seed mass (LHS); and R*, used to classify grassland species are described by the author. There are three distinct groups of mammalian herbivores based on the ways that herbivores harbor cellulose degrading microbes: hindgut fermentation, foregut fermentation, and foregut fermentation with rumination. Grasslands have a smaller number of bird species than forested systems, and the bird species that are endemic to grasslands tend to be specialized to open habitat (e.g., large flightless birds). Abundant insects can gathered into feeding groups. Single-celled organisms are important in grassland nutrient cycling and as mutualists and pathogens and are extremely abundant in soil. Soil pH is a strong predictor of bacterial diversity (as in plants), with diversity higher in neutral than in acidic soils.
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Levitan, Irwin B., et Leonard K. Kaczmarek. The Neuron. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199773893.001.0001.
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The Fourth Edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. It begins with properties of the many newly discovered ion channels that have emerged through mapping of the genome and which shape the way a single neuron generates varied patterns of electrical activity. It also covers the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. It discusses the biochemical pathways that are linked to the action of neurotransmitters and that can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons, and the rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. Also addressed is the role of ongoing experience and activity in shaping these connections, and the mechanisms thought to underlie the phenomena of learning and memory.
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Narlikar, A. V., et Y. Y. Fu, dir. Oxford Handbook of Nanoscience and Technology. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199533053.001.0001.
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This Handbook presents important developments in the field of nanoscience and technology, focusing on the advances made with a host of nanomaterials including DNA and protein-based nanostructures. Topics include: optical properties of carbon nanotubes and nanographene; defects and disorder in carbon nanotubes; roles of shape and space in electronic properties of carbon nanomaterials; size-dependent phase transitions and phase reversal at the nanoscale; scanning transmission electron microscopy of nanostructures; the use of microspectroscopy to discriminate nanomolecular cellular alterations in biomedical research; holographic laser processing for three-dimensional photonic lattices; and nanoanalysis of materials using near-field Raman spectroscopy. The volume also explores new phenomena in the nanospace of single-wall carbon nanotubes; ZnO wide-bandgap semiconductor nanostructures; selective self-assembly of semi-metal straight and branched nanorods on inert substrates; nanostructured crystals and nanocrystalline zeolites; unusual properties of nanoscale ferroelectrics; structural, electronic, magnetic, and transport properties of carbon-fullerene-based polymers; fabrication and characterization of magnetic nanowires; and properties and potential of protein-DNA conjugates for analytic applications.
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Ladyman, James, et Karoline Wiesner. What Is a Complex System ? Yale University Press, 2020. http://dx.doi.org/10.12987/yale/9780300251104.001.0001.
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What is a complex system? Although “complexity science” is used to understand phenomena as diverse as the behavior of honeybees, the economic markets, the human brain, and the climate, there is no agreement about its foundations. In this introduction for students, academics, and general readers, the authors develop an account of complexity that brings the different concepts and mathematical measures applied to complex systems into a single framework. The book begins with an overview and a brief history of complexity science. Complexity science is relatively new but already indispensable. Many of the most important problems in engineering, medicine, and public policy are now addressed with the ideas and methods of complexity science. The conceptual foundations of complexity science are disputed, and there are many and diverging views among scientists about what complexity and complex systems are. Its origins lie in cybernetics and systems theory and it is related to dynamical systems theory and the study of cellular automata. The book introduces the different features of complex systems and discusses different conceptions of complexity with the authors documenting their own account. In do so, they explain why complexity science is so important in today's world.
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Sklar, Larry A., dir. Flow Cytometry for Biotechnology. Oxford University Press, 2005. http://dx.doi.org/10.1093/oso/9780195183146.001.0001.
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Flow cytometry is a sensitive and quantitative platform for the measurement of particle fluorescence. In flow cytometry, the particles in a sample flow in single file through a focused laser beam at rates of hundreds to thousands of particles per second. During the time each particle is in the laser beam, on the order of ten microseconds, one or more fluorescent dyes associated with that particle are excited. The fluorescence emitted from each particle is collected through a microscope objective, spectrally filtered, and detected with photomultiplier tubes. Flow cytometry is uniquely capable of the precise and quantitative molecular analysis of genomic sequence information, interactions between purified biomolecules and cellular function. Combined with automated sample handling for increased sample throughput, these features make flow cytometry a versatile platform with applications at many stages of drug discovery. Traditionally, the particles studied are cells, especially blood cells; flow cytometry is used extensively in immunology. This volume shows how flow cytometry is integrated into modern biotechnology, dealing with issues of throughput, content, sensitivity, and high throughput informatics with applications in genomics, proteomics and protein-protein interactions, drug discovery, vaccine development, plant and reproductive biology, pharmacology and toxicology, cell-cell interactions and protein engineering.
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Hill, Geoffrey E. Mitonuclear Ecology. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198818250.001.0001.
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Eukaryotes were born of a chimeric union of two prokaryotes. The legacy of this fusion is organisms with both a nuclear and mitochondrial genome that must work in a coordinated fashion to enable cellular respiration. The coexistence of two genomes in a single organism requires tight coadaptation to enable function. The need for coadaptation, the challenge of co-transmission, and the possibility of genomic conflict between mitochondrial and nuclear genes have profound consequences for the ecology and evolution of eukaryotic life. This book defines mitonuclear ecology as an emerging field that reassesses core concepts in evolutionary ecology in light of the necessity of mitonuclear coadaptation. I discuss and summarize research that tests new mitonuclear-based theories for the evolution of sex, two sexes, senescence, a sequestered germ line, speciation, sexual selection, and adaptation. The ideas presented in this book represent a paradigm shift for evolutionary ecology. Through the twentieth century, mitochondrial genomes were dismissed as unimportant to the evolution of complex life because variation within mitochondrial genomes was proposed to be functionally neutral. These conceptions about mitochondrial genomes and mitonuclear genomic interactions have been changing rapidly, and a growing literature in top journals is making it increasingly clear that the interactions of the mitochondrial and nuclear genomes over the past 2 billion years have played a major role in shaping the evolution of eukaryotes. These new hypotheses for the evolution of quintessential characteristics of complex life hold the potential to fundamentally reshape the field of evolutionary ecology and to inform the emerging fields of mitochondrial medicine and mitochondrial-based reproductive therapies.
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Roe, Simon, dir. Protein Purification Techniques. Oxford University Press, 2001. http://dx.doi.org/10.1093/oso/9780199636747.001.0001.
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Proteins are an integral part of molecular and cellular structure and function and are probably the most purified type of biological molecule. In order to elucidate the structure and function of any protein it is first necessary to purify it. Protein purification techniques have evolved over the past ten years with improvements in equipment control, automation, and separation materials, and the introduction of new techniques such as affinity membranes and expanded beds. These developments have reduced the workload involved in protein purification, but there is still a need to consider how unit operations linked together to form a purification strategy, which can be scaled up if necessary. The two Practical Approach books on protein purification have therefore been thoroughly updated and rewritten where necessary. The core of both books is the provision of detailed practical guidelines aimed particularly at laboratory scale purification. Information on scale-up considerations is given where appropriate. The books are not comprehensive but do cover the major laboratory techniques and common sources of protein. Protein Purification Techniques focuses on unit operations and analytical techniques. It starts with an overview of purification strategy and then covers initial extraction and clarification techniques. The rest of the book concentrates on different purification methods with the emphasis being on chromatography. The final chapter considers general scale-up considerations. Protein Purification Applications describes purification strategies from common sources: mammalian cell culture, microbial cell culture, milk, animal tissue, and plant tissue. It also includes chapters on purification of inclusion bodies, fusion proteins, and purification for crystallography. A purification strategy that can produce a highly pure single protein from a crude mixture of proteins, carbohydrates, lipids, and cell debris to is a work of art to be admired. These books (available individually or as a set)are designed to give the laboratory worker the information needed to undertake the challenge of designing such a strategy.
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Reber, Arthur S. The First Minds. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190854157.001.0001.
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The book presents a novel theory of the origins of mind and consciousness dubbed the Cellular Basis of Consciousness (CBC). It argues that sentience emerged with life itself. The most primitive unicellular species of bacteria are conscious, though it is a sentience of a primitive kind. They have minds, though they are tiny and limited in scope. There is nothing even close to this thesis in the current literature on consciousness. Hints that cells might be conscious can be found in the writings of a few cell biologists, but a fully developed theory has never been put forward before. Other approaches to the origins of consciousness are examined and shown to be seriously or fatally flawed, specifically ones based on: (a) the assumption that minds are computational and can be captured by an artificial intelligence (AI), (b) efforts to discover the neurocorrelates of mental experiences, the so-called Hard Problem, and (c) looking for consciousness in less complex species by identifying those that possess precursors of those neurocorrelates. Each of these approaches is shown to be either essentially impossible (the AI models) or so burdened by philosophical and empirical difficulties that they are effectively unworkable. The CBC approach is developed using standard models of evolutionary biology. The remarkable repertoire of single-celled species that micro- and cell-biologists have discovered is reviewed. Bacteria, for example, have sophisticated sensory and perceptual systems, learn, form memories, make decisions based on information about their environment relative to internal metabolic states, communicate with one another, and even show a primitive form of altruism. All such functions are indicators of sentience. Conversations with a caterpillar function as a literary vehicle Finally, the implications of the CBC model are discussed along with a number of related issues in evolutionary biology, philosophy of mind, the possibility of sentient plants, the ethical repercussions of universal animal sentience, and the long-range impact of adopting the CBC stance.
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Vaheri, Antti, James N. Mills, Christina F. Spiropoulou et Brian Hjelle. Hantaviruses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0035.
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Hantaviruses (genus Hantavirus, family Bunyaviridae) are rodent- and insectivore-borne zoonotic viruses. Several hantaviruses are human pathogens, some with 10-35% mortality, and cause two diseases: hemorrhagic fever with renal syndrome (HFRS) in Eurasia, and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Hantaviruses are enveloped and have a three-segmented, single-stranded, negative-sense RNA genome. The L gene encodes an RNA-dependent RNA polymerase, the M gene encodes two glycoproteins (Gn and Gc), and the S gene encodes a nucleocapsid protein. In addition, the S genes of some hantaviruses have an NSs open reading frame that can act as an interferon antagonist. Similarities between phylogenies have suggested ancient codivergence of the viruses and their hosts to many authors, but increasing evidence for frequent, recent host switching and local adaptation has led to questioning of this model. Infected rodents establish persistent infections with little or no effect on the host. Humans are infected from aerosols of rodent excreta, direct contact of broken skin or mucous membranes with infectious virus, or rodent bite. One hantavirus, Andes virus, is unique in that it is known to be transmitted from person-to-person. HFRS and HCPS, although primarily affecting kidneys and lungs, respectively, share a number of clinical features, such as capillary leakage, TNF-, and thrombocytopenia; notably, hemorrhages and alterations in renal function also occur in HCPS and cardiac and pulmonary involvement are not rare in HFRS. Of the four structural proteins, both in humoral and cellular immunity, the nucleocapsid protein appears to be the principal immunogen. Cytotoxic T-lymphocyte responses are seen in both HFRS and HCPS and may be important for both protective immunity and pathogenesis. Diagnosis is mainly based on detection of IgM antibodies although viral RNA (vRNA) may be readily, although not invariably, detected in blood, urine and saliva. For sero/genotyping neutralization tests/RNA sequencing are required. Formalin-inactivated vaccines have been widely used in China and Korea but not outside Asia. Hantaviruses are prime examples of emerging and re-emerging infections and, given the limited number of rodents and insectivores thus far studied, it is likely that many new hantaviruses will be detected in the near future.