Thèses sur le sujet « Single target »
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Crockett, Mark T. « Target Motion Estimation Techniques for Single-Channel SAR ». BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/4111.
Texte intégralHristova, Ivana. « Transverse-target single-spin azimuthal asymmetry in hard exclusive electroproduction of single pions at HERMES ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15839.
Texte intégralWe present the analysis of data taken in the years 2002-2004 with the 27.56 GeV positron beam of the HERA storage ring at DESY and the internal transversely polarised hydrogen fixed target of the HERMES experiment. Events with a scattered positron and a produced pion are selected. Exclusive production of single pions, e p -> e'' n pi+, is ensured by requiring the missing mass in the event to be equal to the mass of the neutron, which is not detected. The cross section for this process depends on the Bjorken scaling variable, the four-momentum transfer, and the transverse four-momentum transfer, whose average values for our sample are =0.12, =2.3 GeV^2, =-0.18 GeV^2, respectively, and two azimuthal angles: the angle phi between the scattering and production planes (their common line contains the virtual photon), and the angle phi_S between the scattering plane and the target polarisation vector. The asymmetry, also called transverse-target single-spin azimuthal asymmetry, is defined as the ratio of the difference to the sum of the cross sections for positive and negative target polarisation. It is characterised by six azimuthal sine modulations, whose amplitudes can vary from -1 to 1. We measure the asymmetry from a sample of 2093 events with a signal-to-background ratio of 1:1. At average kinematics, the values of the amplitudes are found to be small or consistent with zero, except for the amplitude of the sin(phi_S) modulation, however, within their large statistical uncertainties. A direct and more precise data-to-theory comparison requires larger statistics and improved detector capabilities than available for the present measurement.
Iovenitti, Pio Gioacchino, et piovenitti@swin edu au. « Three-dimensional measurement using a single camera and target tracking ». Swinburne University of Technology, 1997. http://adt.lib.swin.edu.au./public/adt-VSWT20060724.151747.
Texte intégralGok, Sercan. « Fuzzy Decision Fusion For Single Target Classification In Wireless Sensor Networks ». Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611296/index.pdf.
Texte intégralCarlhamn, Rasmussen Liv. « Evaluation of Cu2ZnSnS4 Absorber Films Sputtered from a Single, Quaternary Target ». Thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199838.
Texte intégralMatsunaga, Shinichiro. « A single-chip CMOS tracking image sensor for a complex target ». Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/15285.
Texte intégralSecmen, Mustafa. « A Novel Music Algorithm Based Electromagnetic Target Recognition Method In Resonance Region For The Classification Of Single And Multiple Targets ». Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/2/12609306/index.pdf.
Texte intégralMUSIC Spectrum Matrices (MSMs)&rdquo
are constructed for each candidate target at each reference aspect angle using targets&rsquo
scattered data at different late-time intervals. These individual MSMs correspond to maps of targets&rsquo
natural-resonance related power distributions. All these patterns are first used to obtain optimal late-time interval for classifier design and a &ldquo
Fused MUSIC Spectrum Matrix (FMSM)&rdquo
is generated over this interval for each target by superposing MSMs. The resulting FMSMs include more complete information for target resonances and are almost insensitive to aspect and polarization. In case of multiple target recognition, the relative locations of a multi-target group and separation distance between targets are also important factors. Therefore, MSM features are computed for each multi-target group at each &ldquo
reference aspect/topology&rdquo
combination to determine the optimum late-time interval. The FMSM feature of a given multi-target group is obtained by the superposition of all these aspect and topology dependent MSMs. In both single and multiple target recognition cases, the resulting FMSM power patterns are main target features of the designed classifier to be used during real-time decisions. At decision phase, the unknown test target is classified either as one of the candidate targets or as an alien target by comparing correlation coefficients computed between MSM of test signal and FMSM of each candidate target.
Naeem, Asad. « Single and multiple target tracking via hybrid mean shift/particle filter algorithms ». Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/12699/.
Texte intégralBarker, Amy Magoolagan. « Evaluating a single-stranded RNA genome as an anti-viral drug target ». Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20768/.
Texte intégralOakey, Mary E. « Developing a Quantitative Means for Evaluating Single Isocenter Multi-Target SRS Plans ». University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556908025631349.
Texte intégralTrevisoli, Priscila Anchieta. « Association of predicted deleterious single nucleotide polymorphisms with carcass traits in meat-type chickens ». Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-21082018-152925/.
Texte intégralO melhoramento genético é o principal responsável pelo aumento da eficiência da produção avícola nas últimas décadas e os programas de melhoramento de aves estão direcionados para um maior rendimento de carne e eficiência alimentar. Dentre as abordagens genômicas, estudos de associação genômica ampla (GWAS) identificaram loci associados com características quantitativas (QTLs) de carcaça em uma população de frangos de corte. Análise de GWAS identifica regiões em desequilíbrio de ligação com possíveis mutações causais e com o objetivo de refinar esses resultados, estudos de associações usando polimorfismos de base única (SNPs) não sinônimos podem ser úteis. O SNP não sinônimo pode ser predito como deletério por meio do Sorting Intolerant From Tolerant (SIFT) score quando a alteração de aminoácidos tem o potencial de impactar a função da proteína e consequentemente pode afetar o fenótipo. Portanto, neste estudo, SNPs preditos como deletérios localizados em regiões de QTLs foram identificados e associados com peso e rendimento de coxa, sobrecoxa, gordura abdominal e peito de frangos de corte. Modelo misto foi utilizado, com sexo, incubação e genótipos dos SNPs como efeitos fixos e família como efeito aleatório. De 20 SNPs analisados, seis foram associados significativamente (p<0,05) com peso e rendimento de coxa, sobrecoxa e peito, e três deles rs736010549, rs739508259 e rs313532967 estão presentes nos genes WDR77, VWA8 e BARL, respectivamente. Estes genes estão relacionados com processos biológicos como via de sinalização de esteroide, receptores de estrogênio e de ácidos biliares. Nossa estratégia permitiu a identificação de potenciais mutações causais associadas com crescimento e desenvolvimento muscular.
Xiao, Jingjing. « Single-target tracking of arbitrary objects using multi-layered features and contextual information ». Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6688/.
Texte intégralOztan, Baha Baran. « Linear Prediction For Single Snapshot Multiple Target Doppler Estimation Under Possibly Moving Radar Clutter ». Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609741/index.pdf.
Texte intégralr-Rao bounds. We have analyzed linear prediction, together with its efficient implementation invented by Tufts &
Kumaresan, and compared its performance to other high resolution frequency estimation algorithms all modified to run under clutter. The essential part of the work is that line spectra estimation techniques model the clutter process also as a complex exponential. In addition, linear prediction combined with linear time&ndash
invariant maximum Signal to Interference Ratio (SIR) processor is analyzed. A technique to determine the model order, which is required by the frequency estimation algorithms, is presented that does not distinguish between targets and clutter. Clutter region concept is introduced to identify targets from clutter. The possibility to use these algorithms for target classification is briefly explained after providing a literature survey on helicopter echoes.
Zajac, Pawel. « Parallel target selection by trinucleotide threading ». Doctoral thesis, KTH, Genteknologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11284.
Texte intégralQC 20100819
Leschhorn, Günther. « Time-resolved measurements on a single molecular target and Discrete Kink Solitons in Ion traps ». Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-139027.
Texte intégralChan, N. M. M. « Isolation of a single chain antibody fragment specific to a molecular target of MLL leukaemias ». Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597424.
Texte intégralAlkhairy, Sahar Ashraf. « Comprehensive single and paired drug target identification in healthy and disease models of NF-kB pathway ». Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105937.
Texte intégralThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 81-82).
Nuclear NF-[kappa]B ("NF-[kappa]Bn") is a transcription factor responsible for regulating many genes that play important roles in inter- and intra-cellular signaling, cellular stress responses, cell growth, survival and apoptosis. Defective levels of NF-[kappa]Bn has been associated with cancer, inflammatory, and autoimmune diseases. Therefore, it is important to identify species in the NF-[kappa]B pathway that if inhibited/ targeted by added drugs normalize the levels of NF-[kappa]Bn. Also, since there is a limit to how effective single drug targets are in complicated diseases, identification of combinations of targets is very important. Existing experimental and computational work are disease specific, not comprehensive as they only analyze specific drug targets, and rarely analyze combinations of targets. In this thesis, we computationally modify a healthy model of the pathway to reflect what is defective in different classes of diseases. Then for each of the healthy and disease models, we score individual targets based on how much change in concentration of NF-[kappa]Bn they induce when inhibited with an added inhibitor. Furthermore, we explain (1) why certain species score better than others, (2) why the inhibition profile of the output (NF-[kappa]Bn) is not linear, and (3) why some isoforms of the same species score better than others. We also classify pairs of targets based on whether they are synergistic, additive, or antagonistic and obtain general trends for synergism of target combinations. Finally, we provide a comparison of the identified best targets with previously identified ones. One of our main findings is that very few species are effective at low levels of inhibition but many are effective at extremely high levels of inhibition. We also find that the scores of the species greatly depend on their steady state concentrations, the relative reaction parameters such as nuclear import/export rates and synthesis rates, and the relative concentrations of IKK and NF-[kappa]B. Furthermore, we find that all species that have some effect on the output are synergistic with one another. In departure from other approaches we have computationally targeted both individual proteins and protein complexes, rather than just individual proteins. Although protein complexes score better they are more difficult to inhibit physically.
by Sahar Ashraf Alkhairy.
M. Eng. in Computer Science and Molecular Biology
Don, Nicola. « A single molecule approach to investigate how AP1 transcriptional regulators find their target sites on DNA ». Thesis, University of Essex, 2015. http://repository.essex.ac.uk/16580/.
Texte intégralWinkler, Joseph W. « An Investigation into Ground Moving Target Indication (GMTI) Using a Single-Channel Synthetic Aperture Radar (SAR) ». BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3555.
Texte intégralGittens, Shaun. « Neural network generation of temporal sequences from single static vector inputs using varying length distal target sequences ». College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/6710.
Texte intégralThesis research directed by: Computer Science. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
Croci, R. « RNA DEPENDENT RNA POLYMERASE : A VALUABLE TARGET TO BLOCK VIRAL REPLICATION IN SINGLE-STRANDED (+)SENSE RNA VIRUSES ». Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/243352.
Texte intégralDutta, Chiranjib. « MEASUREMENT OF SINGLE-TARGET SPIN ASYMMETRIES IN THE ELECTROPRODUCTION OF NEGATIVE PIONS IN THE SEMI-INCLUSIVE DEEP INELASTIC REACTION n↑(e,éπ¯)X ON A TRANSVERSELY POLARIZED 3He TARGET ». UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/29.
Texte intégralRécamier, Vincent. « Single particle imaging in the cell nucleus : a quantitative approach ». Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00998389.
Texte intégralKeaikitse, Advice Seiphemo. « Long-term tracking of multiple interacting pedestrians using a single camera ». Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86632.
Texte intégralENGLISH ABSTRACT: Object detection and tracking are important components of many computer vision applications including automated surveillance. Automated surveillance attempts to solve the challenges associated with closed-circuit camera systems. These include monitoring large numbers of cameras and the associated labour costs, and issues related to targeted surveillance. Object detection is an important step of a surveillance system and must overcome challenges such as changes in object appearance and illumination, dynamic background objects like ickering screens, and shadows. Our system uses Gaussian mixture models, which is a background subtraction method, to detect moving objects. Tracking is challenging because measurements from the object detection stage are not labelled and could be from false targets. We use multiple hypothesis tracking to solve this measurement origin problem. Practical long-term tracking of objects should have re-identi cation capabilities to deal with challenges arising from tracking failure and occlusions. In our system each tracked object is assigned a one-class support vector machine (OCSVM) which learns the appearance of that object. The OCSVM is trained online using HSV colour features. Therefore, objects that were occluded or left the scene can be reidenti ed and their tracks extended. Standard, publicly available data sets are used for testing. The performance of the system is measured against ground truth using the Jaccard similarity index, the track length and the normalized mean square error. We nd that the system performs well.
AFRIKAANSE OPSOMMING: Die opsporing en volging van voorwerpe is belangrike komponente van baie rekenaarvisie toepassings, insluitend outomatiese bewaking. Outomatiese bewaking poog om die uitdagings wat verband hou met geslote kring kamera stelsels op te los. Dit sluit in die monitering van groot hoeveelhede kameras en die gepaardgaande arbeidskoste, en kwessies wat verband hou met toegespitse bewaking. Die opsporing van voorwerpe is 'n belangrike stap in 'n bewakingstelsel en moet uitdagings soos veranderinge in die voorwerp se voorkoms en beligting, dinamiese agtergrondvoorwerpe soos ikkerende skerms, en skaduwees oorkom. Ons stelsel maak gebruik van Gaussiese mengselmodelle, wat 'n agtergrond-aftrek metode is, om bewegende voorwerpe op te spoor. Volging is 'n uitdaging, want afmetings van die voorwerp-opsporing stadium is nie gemerk nie en kan afkomstig wees van valse teikens. Ons gebruik verskeie hipotese volging (multiple hypothesis tracking ) om hierdie meting-oorsprong probleem op te los. Praktiese langtermynvolging van voorwerpe moet heridenti seringsvermoëns besit, om die uitdagings wat voortspruit uit mislukte volging en okklusies te kan hanteer. In ons stelsel word elke gevolgde voorwerp 'n een-klas ondersteuningsvektormasjien (one-class support vector machine, OCSVM) toegeken, wat die voorkoms van daardie voorwerp leer. Die OCSVM word aanlyn afgerig met die gebruik van HSV kleurkenmerke. Daarom kan voorwerpe wat verdwyn later her-identi seer word en hul spore kan verleng word. Standaard, openbaar-beskikbare datastelle word vir toetse gebruik. Die prestasie van die stelsel word gemeet teen korrekte afvoer, met behulp van die Jaccard ooreenkoms-indeks, die spoorlengte en die genormaliseerde gemiddelde kwadraatfout. Ons vind dat die stelsel goed presteer.
Gulez, Taner. « Weapon-target Allocation And Scheduling For Air Defense With Time Varying Hit Probabilities ». Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608471/index.pdf.
Texte intégralBALAPA, MANOHAR. « A HEURISTIC FLIGHT PATH PLANNER FOR A SMALL UAV ATTEMPTING TO FIND A SINGLE TARGET IN MINIMUM TIME ». University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1201285427.
Texte intégralKissel, Jay D. « Target specificity and structural characterization of single-stranded DNA aptamer RT1t49, a broad inhibitor of HIV-1 reverse transcriptases ». [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3274917.
Texte intégralSource: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4320. Adviser: Donald H. Burke-Aguero. Title from dissertation home page (viewed Apr. 22, 2008).
Alexander, Jason S. « Interference effects due to projective-target nucleus scattering in single ionization of molecular hydrogen by 75 keV proton impact ». Diss., Rolla, Mo. : Missouri University of Science and Technology, 2009. http://scholarsmine.mst.edu/thesis/pdf/Alexander_09007dcc8064b51f.pdf.
Texte intégralVita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed April 27, 2009) Includes bibliographical references (p. 70-74).
Ozkilic, Sibel. « Performance Improvement Of A 3-d Configuration Reconstruction Algorithm For An Object Using A Single Camera Image ». Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/1095793/index.pdf.
Texte intégralHales, Audra Marie. « Using Systematic and Engaging Early Literacy Instruction and Digital Books to Teach At-Risk Kindergarteners to Read Target Words ». BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3468.
Texte intégralBjering, Beatrice. « Estimations of 3D velocities from a single camera view in ice hockey ». Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-254320.
Texte intégralIshockey är en kontaktsport med hög risk för hjärnskador, så som hjärnskakningar. Detta är ett stort hälsoproblem och det finns ett behov av större förståelse mellan huvudets kinematik och hjärnskakningar. Hastigheten och riktningen av kollisionerna är faktorer som kan påverka svårighetsgraden av hjärnskakningarna. Därför kan förståelsen av hjärnskakningar förbättras genom att extrahera hastigheter med videoanalys. I denna rapport utvecklades en prototyp för att ta fram 3D hastigheter från en kameravinkel genom att använda målsökningsalgoritmer och homografi. En validering av prototypen gjordes där medelfelet uppskattades till 21.7%. Prototypen utvärderade även 60 fall av tacklingar där 30 resulterade hjärnskakningar och där de andra 30 tacklingarna inte resulterade i hjärnskakningar. Ingen signifikant skillnad mellan de två grupperna kunde påvisas. Medelhastigheten för tacklingarna som resulterade i hjärnskakning var 6.55 m/s för den attackerande spelaren och 4.59 m/s för den skadade spelaren. Prototypen jämfördes också med hastigheter som tagits fram med SkillSpector i ett tidigare kandidatexamensarbete. Det var en signifikant skillnad mellan de hastigheter som togs fram med prototypen och de som tog fram med SkillSpector. En validering av SkillSpector gjordes också, som visade att medelfelet var 37.4%.
Deneault, Dustin. « Tracking ground targets with measurements obtained from a single monocular camera mounted on an Unmanned Aerial Vehicle ». Thesis, Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/528.
Texte intégralKilic, Varlik. « Performance Improvement Of A 3d Reconstruction Algorithm Using Single Camera Images ». Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606259/index.pdf.
Texte intégralLeschhorn, Günther [Verfasser], et Tobias [Akademischer Betreuer] Schätz. « Time-resolved measurements on a single molecular target and Discrete Kink Solitons in Ion traps / Günther Leschhorn. Betreuer : Tobias Schätz ». München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1019479159/34.
Texte intégralSun, Li. « Microfluidic Platform for the Detection of Single Cell Immune Activity and Tag-Free Selection of Individual Target-Cell Responsive Effector Cells ». Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493489.
Texte intégralEngineering and Applied Sciences - Applied Physics
Kazemisaber, Mohammadreza. « Clutter Removal in Single Radar Sensor Reflection Data via Digital Signal Processing ». Thesis, Linnéuniversitetet, Institutionen för fysik och elektroteknik (IFE), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-99874.
Texte intégralKatich, Joseph M. « Measurement of the Target-Normal Single-Spin Asymmetry A(n,y) in the Deep Inelastic Region from the Reaction Helium-3 (e,e') ». W&M ScholarWorks, 2011. https://scholarworks.wm.edu/etd/1539623578.
Texte intégralSaygin, Oktay. « An Effectiveness Evaluation Method For Airburst Projectiles ». Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613202/index.pdf.
Texte intégralUzbaş, Fatma [Verfasser], Heiko [Akademischer Betreuer] Lickert, Heiko [Gutachter] Lickert et Wolfgang [Gutachter] Wurst. « Development of a Novel Target Enrichment and Barcoding Method for Next-Generation Sequencing, and Implementation for Single-Cell Transcriptomics / Fatma Uzbaş ; Gutachter : Heiko Lickert, Wolfgang Wurst ; Betreuer : Heiko Lickert ». München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1221279653/34.
Texte intégralVestin, Albin, et Gustav Strandberg. « Evaluation of Target Tracking Using Multiple Sensors and Non-Causal Algorithms ». Thesis, Linköpings universitet, Reglerteknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160020.
Texte intégralRanu, Navpreet Singh. « Targeted sequencing : single cells and single strand breaks ». Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119977.
Texte intégralCataloged from PDF version of thesis.
Includes bibliographical references (pages 77-92).
Sequencing the human genome has spurred systematic work on understanding how gene expression and genomic integrity contribute to disease. To date, 3,519 genes have been identified as the underlying cause of specific single gene disorders. However, complex diseases still pose a daunting challenge that require both an understanding of cell function as well as how the genome interacts with its cellular environment. Sequencing technologies are now routinely applied to interrogate gene variants, gene expression patterns, chromosome accessibility, among other measurements to infer gene and cell function. We build upon past work to address the challenge of targeting sequencing effort to cells and genomic loci of interest to probe the molecular mechanisms behind disease. In this thesis, we demonstrate two novel targeted sequencing methods that can enable a greater understanding of cell function. (1) The development of targeted sequencing in pooled single cell RNA-seq libraries and (2) the development of a novel sequencing approach that allows for the quantification and identification of single stranded break (SSB) locations across the genome. First, we introduce a new targeted sequencing approach to identify rare cells of interest in pooled sequence libraries. Improved throughput in single cell sequencing has enabled the transcriptional profiling of thousands of cells at once. However, due to reliance on pooled library construction methods, it is now more difficult to focus on and analyze particular cells of interest, apart from analyzing the library in its entirety. We designed multiplex PCR primers to simultaneously enrich targeted cells from a complex DNA library pool of single cells. We show how molecular enrichment can be used to efficiently target rare cell types, such as the recently identified AXL+SIGLEC6+ dendritic cell (AS DC). Next, we demonstrate a new targeted sequencing approach, called NickSeq, to locate and quantify DNA SSBs with single nucleotide resolution. SSBs are the most common form of DNA damage at an estimated 10,000 per cell per day, but there is no available method to robustly determine the exact sites of damage. SSB accumulation correlates with disease, but it is unknown how the location and amount of damage relate to health outcomes. We intentionally create a unique mutational signature at the SSB that is a fingerprint for this specific type of DNA damage when the locus is sequenced. Taken as a whole, we introduce two novel strategies to further understand cell function through studying rare cells in single cell populations and analyzing DNA SSB damage in relation to cell health. This work demonstrates that targeted sequencing approaches have promise for understanding the molecular mechanisms behind aberrant cell function, a necessary step in the prevention and treatment of disease.
by Navpreet Singh Ranu.
Ph. D.
Steyn, G. F., et C. Vermeulen. « Saturation conditions in elongated single-cavity boiling water targets ». Helmholtz-Zentrum Dresden - Rossendorf, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-165869.
Texte intégralRodríguez, Marrero Ana Yaiza. « Measurement of the exclusive ([Ni][Mi subíndex][Ro] -> ; [Mi][- elevat][Ro][Pi][+ elevat]) and inclusive ([Ni][Mi subíndex] N -> ; [Mi][- elevat] N' [Pi][+ elevat]) single pion [Ni] interaction cross section in a carbon target using the SciBar detector at the K2K experiment ». Doctoral thesis, Universitat Autònoma de Barcelona, 2007. http://hdl.handle.net/10803/3392.
Texte intégralBarham, Joshua Philip. « Single electron transfer in organic synthesis targeted towards sustainable manufacture ». Thesis, University of Strathclyde, 2017. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30673.
Texte intégralSuzuki, Motoshi, Yasuhiro Kamei, Shunsuke Yuba et Shin Takagi. « Manipulating behaviors of targeted single cells in vivo by using IR-LEGO ». IEEE, 2009. http://hdl.handle.net/2237/13889.
Texte intégralBain, Amanda Louise. « Investigation of the Physiological Role of Ssb1 using an in-vivo Targeted Mouse Model ». Thesis, Griffith University, 2013. http://hdl.handle.net/10072/366937.
Texte intégralThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
Full Text
Jacksén, Johan. « Improved techniques for CE and MALDI-MS including microfluidic hyphenations foranalysis of biomolecules ». Doctoral thesis, KTH, Analytisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-27342.
Texte intégralQC 20101214
Chemali, Raja. « «In Vitro» evaluation of single walled carbon nanotubes as targeted drug delivery systems ». Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110416.
Texte intégralGrace à leurs propriétés uniques tel que leur grande surface de contact et leur aisance de pénètre les cellules humaines, les nanotubes de carbone sont désormais de prometteurs systèmes de livraison des médicaments. Le but de cette thèse est de rendre les nanotubes de carbone plus biocompatible, et de tester leur habileté de cibler la chimiothérapie vers les cellules cancéreuses qui possèdent les intégrines αvβ3 et les récepteurs EGF. Ces deux récepteurs sont spécifiquement ciblés car ils sont présents en grandes concentrations sur la surface des cellules cancéreuses telles que les cellules colorectales et les cellules du cancer du sein. Les résultats montrent que la modification covalente et non covalente de la surface des nanotubes de carbone augmente leur compatibilité envers les cellules RAW 264.7 et Caco-2 de 17% et 20.8%, respectivement, comparèrent aux nanotubes modifies de façon covalente seulement. Les résultats montrent aussi que la concentration de la chimiothérapie doxorubicine (DOX) était plus grande lorsqu'elle est délivrée par les nanotubes. En effet, la concentration de DOX délivrée par les nanotubes était 1.4 (± 0.3) et 2 (±0.4) fois plus élevée dans les cellules Caco-2 et RAW 264.7, respectivement, que celle de DOX délivrée sans système de livraison. De même, la cyto-toxicité de DOX délivré par les nanotubes de carbone aux cellules RAW 264.7 était 3.6 (± 0.7) fois plus élevée que celle de DOX délivrée sans système de livraison à 48 h post exposition. L'étude montre que les nanotubes de carbone sont capables d'augmenter la concentration du médicament dans les cellules cancéreuses. Pour étudier tout le potentiel des nanotubes de carbone, d'autres études in vivo seront nécessaire.
Lu, Linyu, et 陸林宇. « Investigations into the feasibility of single-strandedoligonucleotide-mediated targeted gene repair in mammalian cells ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38722793.
Texte intégralBoyer, Patrick D. « Single Wall Carbon Nanotube–Protein Complexes and Immune Cells : Uptake, Processing, and Targeted Delivery ». Research Showcase @ CMU, 2015. http://repository.cmu.edu/dissertations/569.
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