Littérature scientifique sur le sujet « Single cell mRNA sequencing »
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Articles de revues sur le sujet "Single cell mRNA sequencing"
Xu, Yunbo, Hongliang Hu, Jie Zheng et Biaoru Li. « Feasibility of Whole RNA Sequencing from Single-Cell mRNA Amplification ». Genetics Research International 2013 (23 décembre 2013) : 1–8. http://dx.doi.org/10.1155/2013/724124.
Texte intégralDhar, Manjima, Reem Khojah, Andy Tay et Dino Di Carlo. « Research highlights : microfluidic-enabled single-cell epigenetics ». Lab on a Chip 15, no 21 (2015) : 4109–13. http://dx.doi.org/10.1039/c5lc90101d.
Texte intégralD’avola, D., C. Villacorta, S. N. Martins-Filho, A. Craig, I. Labgaa, J. V. Felden, A. Kimaada et al. « Single-cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma ». Journal of Hepatology 68 (avril 2018) : S445—S446. http://dx.doi.org/10.1016/s0168-8278(18)31131-0.
Texte intégralNakamoto, Margaret, Mirko Corselli, Ian Taylor et Suraj Saksena. « Single cell multiomic analysis of chronically stimulated T cells displaying hallmarks of T-cell exhaustion ». Journal of Immunology 202, no 1_Supplement (1 mai 2019) : 189.18. http://dx.doi.org/10.4049/jimmunol.202.supp.189.18.
Texte intégralLee, Jeongwoo, Do Young Hyeon et Daehee Hwang. « Single-cell multiomics : technologies and data analysis methods ». Experimental & ; Molecular Medicine 52, no 9 (septembre 2020) : 1428–42. http://dx.doi.org/10.1038/s12276-020-0420-2.
Texte intégralShi, Xiaoshan, Imteaz Siddique, Margaret Nakamoto et Stefanie Mortimer. « Simultaneous mRNA, protein, and immune repertoire profiling of antigen-specific T cells by single cell sequencing ». Journal of Immunology 204, no 1_Supplement (1 mai 2020) : 246.17. http://dx.doi.org/10.4049/jimmunol.204.supp.246.17.
Texte intégralLiu, Wendao, et Noam Shomron. « Analysis of MicroRNA Regulation and Gene Expression Variability in Single Cell Data ». Journal of Personalized Medicine 12, no 10 (21 octobre 2022) : 1750. http://dx.doi.org/10.3390/jpm12101750.
Texte intégralSchoettle, Louis, Xixi Wei, Marlene Garcia-Neurer, Veronkia Zarnitsyna, Rustom Antia, Hao Yan et Joseph Blattman. « DNA origami : single cell analysis of T cell receptors without single cell sorting. (LYM7P.719) ». Journal of Immunology 192, no 1_Supplement (1 mai 2014) : 193.7. http://dx.doi.org/10.4049/jimmunol.192.supp.193.7.
Texte intégralLi, Jiawei, Yi Zhang, Cheng Yang et Ruiming Rong. « Discrepant mRNA and Protein Expression in Immune Cells ». Current Genomics 21, no 8 (21 décembre 2020) : 560–63. http://dx.doi.org/10.2174/1389202921999200716103758.
Texte intégralBattich, Nico, Joep Beumer, Buys de Barbanson, Lenno Krenning, Chloé S. Baron, Marvin E. Tanenbaum, Hans Clevers et Alexander van Oudenaarden. « Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies ». Science 367, no 6482 (5 mars 2020) : 1151–56. http://dx.doi.org/10.1126/science.aax3072.
Texte intégralThèses sur le sujet "Single cell mRNA sequencing"
Johnson, Travis Steele. « Integrative approaches to single cell RNA sequencing analysis ». The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586960661272666.
Texte intégralBorgström, Erik. « Technologies for Single Cell Genome Analysis ». Doctoral thesis, KTH, Genteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-181059.
Texte intégralQC 20160127
La, Forest Divonne Sébastien De. « Caractérisation constitutive et en condition d'infection bactérienne des populations hémocytaires par une approche intégrative cytologiques, transcriptomiques et fonctionnelles chez l'huitre creuse Crassostrea (Magallana) gigas ». Electronic Thesis or Diss., Perpignan, 2024. http://www.theses.fr/2024PERP0025.
Texte intégralThe Pacific oyster, Crassostrea (Magallana) gigas, is a bivalve mollusk of significant ecological and economic importance, and it has recently emerged as a model species for studying the innate immunity of bivalves. In recent years, oyster farming has been confronted with episodes of massive mortality, exacerbated by climate change and human activities. These mortalities, though multifactorial, share a common factor: the ability of pathogens (viruses and bacteria) to evade the oysters' immune defenses, often leading to fatal septicemia. While immune cells in vertebrates, particularly humans, are well characterized, the diversity and functional specialization of hemocytes in C. gigas remain a black box and are hotly debated within the scientific community. This knowledge gap hampers our understanding of host-pathogen interactions, thus limiting the development of strategies to reduce oyster mortality in aquaculture. In this context, the main objective of my thesis project was to characterize the circulating hemocyte types in C. gigas using cytological, functional, and single-cell transcriptomic approaches (scRNA-seq). These methods first allowed us to identify seven distinct constitutive hemocyte types in naïve animals. These hemocyte populations were characterized based on their morphological properties, gene expression profiles, and specific biological functions. Furthermore, we established a hemocyte ontology, suggesting potential differentiation pathways for the cell lineages. Using this hemocyte atlas, we then assessed the differential impact of Vibrio aestuarianus infection on hemocyte populations, both from a cytological and transcriptomic perspective, revealing alterations dependent on the circulating bacterial load. This work provides a significant contribution to the understanding of immunity in C. gigas, by offering a precise definition of hemocyte types. Our results propose a reference hemocyte atlas and emphasize the importance of studying hemocyte homeostasis in mollusks to better understand and anticipate oyster mortality crises during epizootic episodes
Raoux, Corentin. « Review and Analysis of single-cell RNA sequencing cell-type identification and annotation tools ». Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-297852.
Texte intégralKindblom, Marie, et Hakim Ezeddin Al. « Phylogenetic fatemapping : estimating allelic dropout probability in single cell genomic sequencing ». Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186453.
Texte intégralHenao, Diaz Emanuela. « Towards single-cell exome sequencing with spatial resolution in tissue sections ». Thesis, KTH, Skolan för bioteknologi (BIO), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-150564.
Texte intégralEvrony, Gilad David. « Single-cell Sequencing Studies of Somatic Mutation in the Human Brain ». Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10747.
Texte intégralKe, Rongqin. « Detection and Sequencing of Amplified Single Molecules ». Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183141.
Texte intégralTu, Ang A. (Ang Andy). « Recovery of T cell receptor variable sequences from 3' barcoded single-cell RNA sequencing libraries ». Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127888.
Texte intégralCataloged from PDF version of thesis.
Includes bibliographical references (pages 107-112).
Heterogeneity of the immune system has increasingly necessitated the use of high-resolution techniques, including flow cytometry, RNA-seq, and mass spectrometry, to decipher the immune underpinnings of various diseases such as cancer and autoimmune disorders. In recent years, high-throughput single-cell RNA sequencing (scRNA-seq) has gained popularity among immunologists due to its ability to effectively characterize thousands of individual immune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including variable sequences of T cell antigen receptors (TCRs) that confer antigen specificity. Incorporation of TCR sequencing into scRNA-seq data could identify cells with shared antigen-recognition, further elucidating dynamics of antigen-specific immune responses in T cells.
In the first part of this thesis work, we develop a strategy that enables simultaneous analysis of TCR sequences and corresponding full transcriptomes from 32 barcoded scRNA-seq samples. This approach is compatible with common 32 scRNA-seq methods, and adaptable to processed samples post hoc. We applied the technique to identify transcriptional signatures associated with clonal T cells from murine and human samples. In both cases, we observed preferential phenotypes among subsets of expanded T cell clones, including cytotoxic T cell states associated with immunization against viral peptides. In the second part of the thesis, we apply the strategy to a 12-patient study of peanut food allergy to characterize T helper cell responses to oral immunotherapy (OIT). We identified clonal T cells associated with distinct subsets of T helper cells, including Teff, Treg, and Tfh, as well as Th1, Th2, and Th17 signatures.
We found that though the TCR repertoires of the patients were remarkably stable, regardless of their clinical outcomes, Th1 and Th2 clonotypes were phenotypically suppressed while Tfh clonotypes were not affected by therapy. Furthermore, we observed that highly activated clones were less likely to be suppressed by OIT than less activated clones. Our work represents one of the most detailed transcriptomic profiles of T helper cells in food allergy. In the last part of the thesis, we leverage the simplicity and adaptability of the method to recover TCR sequences from previously processed scRNA-seq samples derived from HIV patients and a nonhuman primate model of TB. In the HIV study, we recovered expanded clonotypes associated with activated T cells from longitudinal samples from patients with acute HIV infections. In the TB study, we modified the primers used in the method to T cells from TB granulomas of cynomolgus macaques.
We identified not only expanded clonotypes associated with cytotoxic functions, but also clonotypes shared by clusters of activated T cells. In total, these results demonstrate the utility of our method when studying diseases in which clonotype-driven responses are critical to understanding the underlying biology.
by Ang A. Tu.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biological Engineering
Lefebvre, Keely. « Resolving the Taxonomy and Phylogenetics of Benthic Diatoms from Single Cell Sequencing ». Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34553.
Texte intégralLivres sur le sujet "Single cell mRNA sequencing"
Suzuki, Yutaka, dir. Single Molecule and Single Cell Sequencing. Singapore : Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-6037-4.
Texte intégralYu, Buwei, Jiaqiang Zhang, Yiming Zeng, Li Li et Xiangdong Wang, dir. Single-cell Sequencing and Methylation. Singapore : Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-4494-1.
Texte intégralWang, Xiangdong, dir. Single Cell Sequencing and Systems Immunology. Dordrecht : Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-017-9753-5.
Texte intégralDing, Hongxu. Understand Biology Using Single Cell RNA-Sequencing. [New York, N.Y.?] : [publisher not identified], 2018.
Trouver le texte intégralLevitin, Hanna M. Biological Inference from Single Cell RNA-Sequencing. [New York, N.Y.?] : [publisher not identified], 2020.
Trouver le texte intégralSuzuki, Yutaka. Single Molecule and Single Cell Sequencing. Springer, 2019.
Trouver le texte intégralMenon, Swapna. Single Cell Sequencing Essentials in Brief : Single Cell RNA Sequencing and Orthogonal Omics Technologies. Independently Published, 2021.
Trouver le texte intégralWang, Xiangdong. Single Cell Sequencing and Systems Immunology. Springer, 2015.
Trouver le texte intégralWang, Xiangdong. Single Cell Sequencing and Systems Immunology. Springer, 2016.
Trouver le texte intégralProserpio, Valentina. Single Cell Methods : Sequencing and Proteomics. Springer New York, 2019.
Trouver le texte intégralChapitres de livres sur le sujet "Single cell mRNA sequencing"
Livak, Kenneth J. « Eukaryotic Single-Cell mRNA Sequencing ». Dans Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing, 343–65. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31350-4_14.
Texte intégralShum, Eleen Y., Elisabeth M. Walczak, Christina Chang et H. Christina Fan. « Quantitation of mRNA Transcripts and Proteins Using the BD Rhapsody™ Single-Cell Analysis System ». Dans Single Molecule and Single Cell Sequencing, 63–79. Singapore : Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-6037-4_5.
Texte intégralVanlandewijck, Michael, et Christer Betsholtz. « Single-Cell mRNA Sequencing of the Mouse Brain Vasculature ». Dans Methods in Molecular Biology, 309–24. New York, NY : Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8712-2_21.
Texte intégralDe Simone, Marco, Grazisa Rossetti et Massimiliano Pagani. « Chromium 10× Single-Cell 3′ mRNA Sequencing of Tumor-Infiltrating Lymphocytes ». Dans Methods in Molecular Biology, 87–110. New York, NY : Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9240-9_7.
Texte intégralMeyer, Michelle, et Palaniappan Ramanathan. « Droplet-Based Single-Cell 3′ mRNA Sequencing of Marburg Virus-Infected Samples ». Dans Methods in Molecular Biology, 387–405. New York, NY : Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-4256-6_27.
Texte intégralSanada, Chad D., et Aik T. Ooi. « Single-Cell Dosing and mRNA Sequencing of Suspension and Adherent Cells Using the PolarisTM System ». Dans Methods in Molecular Biology, 185–95. New York, NY : Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9240-9_12.
Texte intégralDurruthy-Durruthy, Robert, et Manisha Ray. « Using Fluidigm C1 to Generate Single-Cell Full-Length cDNA Libraries for mRNA Sequencing ». Dans Methods in Molecular Biology, 199–221. New York, NY : Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7471-9_11.
Texte intégralBarreby, Emelie, et Connie Xu. « Kupffer Cell mRNA Sequencing ». Dans Methods in Molecular Biology, 27–44. New York, NY : Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0704-6_5.
Texte intégralZhu, Chenxu, Yun Gao, Jinying Peng, Fuchou Tang et Chengqi Yi. « Single-Cell 5fC Sequencing ». Dans Methods in Molecular Biology, 251–67. New York, NY : Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9240-9_16.
Texte intégralKohn, Andrea B., Tatiana P. Moroz, Jeffrey P. Barnes, Mandy Netherton et Leonid L. Moroz. « Single-Cell Semiconductor Sequencing ». Dans Methods in Molecular Biology, 247–84. Totowa, NJ : Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-556-9_18.
Texte intégralActes de conférences sur le sujet "Single cell mRNA sequencing"
Barmpas, Petros, Sotiris K. Tasoulis, Spiros V. Georaakonoulos et Vassilis P. Plagianakos. « Hyperdimensional Computing Approaches in Single Cell RNA Sequencing Classification ». Dans 2024 IEEE Congress on Evolutionary Computation (CEC), 1–8. IEEE, 2024. http://dx.doi.org/10.1109/cec60901.2024.10612207.
Texte intégralHu, Can, et Yuxia Sheng. « Hypergraph-based Clustering for Single-Cell RNA Sequencing Data ». Dans 2024 43rd Chinese Control Conference (CCC), 3529–34. IEEE, 2024. http://dx.doi.org/10.23919/ccc63176.2024.10662510.
Texte intégralDong, Bowen, Sarabjot Pabla, Vincent Giamo, Weijian Jiang, Kiyomi Taniguchi, Sean T. Glenn, Masataka Shirai et Pawel Kalinski. « Abstract 968 : Distinct pathways of DC-induced CD8+T cell differentiation revealed by single-cell mRNA sequencing analysis ». Dans Proceedings : AACR Annual Meeting 2020 ; April 27-28, 2020 and June 22-24, 2020 ; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-968.
Texte intégralSiddique, Imteaz, Xiaoshan Shi, Margaret Nakamoto et Stefanie Mortimer. « Abstract 1344 : Simultaneous mRNA, protein, and immune repertoire profiling of antigen-specific T cells by single cell sequencing ». Dans Proceedings : AACR Annual Meeting 2020 ; April 27-28, 2020 and June 22-24, 2020 ; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1344.
Texte intégralTrump, S., J. Loske, M. T. Völker, O. Debnath, S. Lukassen, N. Ishaque, M. Messingschlager et al. « Single cell mRNA sequencing of nasal swabs indicate an impaired ciliated cell function in COVID-19 convalescents with persisting dyspnea ». Dans ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.4377.
Texte intégralEgidio, Camila, Michael Gonzales, Joel Brockman, Shuwen Chen, Robert Durruthy-Durruthy, Clare Rogers et Manisha Ray. « Abstract LB-078 : Improved single-cell mRNA sequencing for transcriptome and paired-chain TCR analysis of primary human CD3+ T cells ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-lb-078.
Texte intégralSeinstra, D., L. Kester, D. Van der Velden, J. Wesseling, E. Voest, A. Van Oudenaarden et J. Van Rheenen. « PO-337 Single cell mRNA sequencing reveals the presence of the gene expression signature of all major molecular subtypes in individual breast cancers ». Dans Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.849.
Texte intégralGiamo, Vincent, Melissa Grimm, Sarabjot Pabla, Ellen Karasik, Jesse Luce, Sean T. Glenn, Jeffrey Conroy et al. « Abstract 970 : Single-cell mRNA sequencing analysis of the synergistic impact of double-stranded RNA (dsRNA) and IFNα on human monocyte-derived macrophages ». Dans Proceedings : AACR Annual Meeting 2020 ; April 27-28, 2020 and June 22-24, 2020 ; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-970.
Texte intégralAlrhmoun, S., O. Yu Perik-Zavodskaia, M. O. Volynets, Yu A. Lopatnikova, Yu A. Shevchenko, M. S. Fisher, R. Yu Perik‑Zavodskii, V. V. Kurilin, A. N. Silkov et S. V. Sennikov. « OBTAINING FULL SEQUENCES OF CD8+ T-CELL RECEPTORS SPECIFIC TO THE TUMOR-ASSOCIATED ANTIGEN HER-2/NEU USING SINGLE CELL MRNA SEQUENCING AND ERGO-II NEURAL NETWORK ». Dans OpenBio-2023. ИПЦ НГУ, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-9.
Texte intégralBaker, J. B., M. P. McGrogan, C. Simonsen, R. L. Gronke et B. W. Festoff. « STRUCTURE AND PROPERTIES OF PROTEASE NEXIN I ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644765.
Texte intégralRapports d'organisations sur le sujet "Single cell mRNA sequencing"
Oskolkov, Nikolay. Single Cell Data Analysis. Instats Inc., 2024. http://dx.doi.org/10.61700/23nmyqoprtfw01698.
Texte intégralHarouaka, Ramdane. Platform for Single-Cell Dual RNA Sequencing of Host-Pathogen Interactions. Office of Scientific and Technical Information (OSTI), octobre 2021. http://dx.doi.org/10.2172/1832283.
Texte intégralFung, N. DNA sequencing with capillary electrophoresis and single cell analysis with mass spectrometry. Office of Scientific and Technical Information (OSTI), mars 1998. http://dx.doi.org/10.2172/348902.
Texte intégralHovav, Ran, Peggy Ozias-Akins et Scott A. Jackson. The genetics of pod-filling in peanut under water-limiting conditions. United States Department of Agriculture, janvier 2012. http://dx.doi.org/10.32747/2012.7597923.bard.
Texte intégralTucker, Mark L., Shimon Meir, Amnon Lers, Sonia Philosoph-Hadas et Cai-Zhong Jiang. Elucidation of signaling pathways that regulate ethylene-induced leaf and flower abscission of agriculturally important plants. United States Department of Agriculture, janvier 2012. http://dx.doi.org/10.32747/2012.7597929.bard.
Texte intégralBacharach, Eran, et Sagar Goyal. Generation of Avian Pneumovirus Modified Clones for the Development of Attenuated Vaccines. United States Department of Agriculture, novembre 2008. http://dx.doi.org/10.32747/2008.7696541.bard.
Texte intégralHansen, Peter J., et Zvi Roth. Use of Oocyte and Embryo Survival Factors to Enhance Fertility of Heat-stressed Dairy Cattle. United States Department of Agriculture, août 2011. http://dx.doi.org/10.32747/2011.7697105.bard.
Texte intégralPalmer, Guy, Varda Shkap, Wendy Brown et Thea Molad. Control of bovine anaplasmosis : cytokine enhancement of vaccine efficacy. United States Department of Agriculture, mars 2007. http://dx.doi.org/10.32747/2007.7695879.bard.
Texte intégralFahima, Tzion, et Jorge Dubcovsky. Map-based cloning of the novel stripe rust resistance gene YrG303 and its use to engineer 1B chromosome with multiple beneficial traits. United States Department of Agriculture, janvier 2013. http://dx.doi.org/10.32747/2013.7598147.bard.
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