Littérature scientifique sur le sujet « Sindromi mieloproliferative »
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Articles de revues sur le sujet "Sindromi mieloproliferative"
Aznar, Justo. « Could iPS cells be clinically useful ? » Medicina e Morale 59, no 2 (30 avril 2010). http://dx.doi.org/10.4081/mem.2010.218.
Texte intégralThèses sur le sujet "Sindromi mieloproliferative"
Vener, C. « Caratteristiche morfologiche delle sindromi mieloproliferative croniche valutate su biopsie oesteomidollari ». Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/54065.
Texte intégralBaldazzi, Carmen <1980>. « Caratterizzazione Citogenetico-Molecolare delle alterazioni cromosomiche 3q26 e 1p36 nelle Sindromi Mieloproliferative ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5691/1/baldazzi_carmen_tesi.pdf.
Texte intégralEVI1 and PRDM16 overexpression has been associated with poor prognosis in myeloid malignancies. The main mechanism is the rearrangement of chromosome bands 3q26 and 1p36, where they are mapped, respectively. Overexpression has also been reported in specific cytogenetic subgroups, without 3q26 and 1p36 abnormalities observable by chromosome banding analysis (CBA). The main aim of this study has been to identify and characterize EVI1 and PRDM16 rearrangements in cases with 3q and 1p cytogenetic abnormalities. EVI1 rearrangements were mainly associated with 3q26 cytogenetic abnormalities, but they have also been demonstrated in 6 cases (6/35;17,1%) without 3q26 cytogenetic involvement, because of complex mechanism and/or ‘cryptic‘ abnormalities. We have also identified new EVI1 rearrangements. Interestingly, two new similar translocations appeared in two brothers. Rearrangements, but also amplifications of PRDM16 resulting in gene overexpression, have often been associated with 1p36 aberrations. EVI1 and PRDM16 analyses have been performed in others cytogenetics subgroups, such as: -7/7q-, normal karyotype, and 3q abnormalities for PRDM16 and 1p for EVI1. EVI1 overexpression was frequent only in -7/7q- group (17.2%;10/58), and in one case was associated with amplification, not seen by CBA, because of metaphases’ poor quality. On the contrary, PRDM16 overexpression has been found in all cytogenetic subgroups, that we have considered. In some cases with complex karyotype, PRDM16 overexpression has been associated with gene amplification. FISH analysis and RQ-PCR have allowed us to identify EVI1 and PRDM16 abnormalities in patients with or without 3q26 and 1p36 abnormalities. Complex rearrangements or metaphases’ poor quality were the main reasons for the failed detection of these abnormalities in CBA. These observations indicate the importance of screening for EVI1 and PRDM16 abnormalities, especially in cases with 3q and 1p cytogenetic abnormalities, to identify at diagnosis patients with poor prognosis that could benefit from more aggressive chemotherapy and/or stem cell transplantation.
Baldazzi, Carmen <1980>. « Caratterizzazione Citogenetico-Molecolare delle alterazioni cromosomiche 3q26 e 1p36 nelle Sindromi Mieloproliferative ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amsdottorato.unibo.it/5691/.
Texte intégralEVI1 and PRDM16 overexpression has been associated with poor prognosis in myeloid malignancies. The main mechanism is the rearrangement of chromosome bands 3q26 and 1p36, where they are mapped, respectively. Overexpression has also been reported in specific cytogenetic subgroups, without 3q26 and 1p36 abnormalities observable by chromosome banding analysis (CBA). The main aim of this study has been to identify and characterize EVI1 and PRDM16 rearrangements in cases with 3q and 1p cytogenetic abnormalities. EVI1 rearrangements were mainly associated with 3q26 cytogenetic abnormalities, but they have also been demonstrated in 6 cases (6/35;17,1%) without 3q26 cytogenetic involvement, because of complex mechanism and/or ‘cryptic‘ abnormalities. We have also identified new EVI1 rearrangements. Interestingly, two new similar translocations appeared in two brothers. Rearrangements, but also amplifications of PRDM16 resulting in gene overexpression, have often been associated with 1p36 aberrations. EVI1 and PRDM16 analyses have been performed in others cytogenetics subgroups, such as: -7/7q-, normal karyotype, and 3q abnormalities for PRDM16 and 1p for EVI1. EVI1 overexpression was frequent only in -7/7q- group (17.2%;10/58), and in one case was associated with amplification, not seen by CBA, because of metaphases’ poor quality. On the contrary, PRDM16 overexpression has been found in all cytogenetic subgroups, that we have considered. In some cases with complex karyotype, PRDM16 overexpression has been associated with gene amplification. FISH analysis and RQ-PCR have allowed us to identify EVI1 and PRDM16 abnormalities in patients with or without 3q26 and 1p36 abnormalities. Complex rearrangements or metaphases’ poor quality were the main reasons for the failed detection of these abnormalities in CBA. These observations indicate the importance of screening for EVI1 and PRDM16 abnormalities, especially in cases with 3q and 1p cytogenetic abnormalities, to identify at diagnosis patients with poor prognosis that could benefit from more aggressive chemotherapy and/or stem cell transplantation.
GUGLIELMELLI, PAOLA. « Correlazioni tra genotipo e fenotipo nelle sindromi mieloproliferative croniche Ph-negative ». Doctoral thesis, 2010. http://hdl.handle.net/2158/599006.
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