Bibliographies thématiques / SILICO ANALYSIS

Littérature scientifique sur le sujet « SILICO ANALYSIS »

Auteur : Grafiati
Publié le 11 septembre 2023

Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres

Choisissez une source :

Sommaire

Consultez les listes thématiques d’articles de revues, de livres, de thèses, de rapports de conférences et d’autres sources académiques sur le sujet « SILICO ANALYSIS ».

À côté de chaque source dans la liste de références il y a un bouton « Ajouter à la bibliographie ». Cliquez sur ce bouton, et nous générerons automatiquement la référence bibliographique pour la source choisie selon votre style de citation préféré : APA, MLA, Harvard, Vancouver, Chicago, etc.

Vous pouvez aussi télécharger le texte intégral de la publication scolaire au format pdf et consulter son résumé en ligne lorsque ces informations sont inclues dans les métadonnées.

Articles de revues sur le sujet "SILICO ANALYSIS"

1

Barik, Dr Bibhuti Prasad. « In Silico Observations and Analysis of Metabolic Pathways ». International Journal of Scientific Research 2, no 11 (1 juin 2012) : 44–48. http://dx.doi.org/10.15373/22778179/nov2013/14.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
2

Chaudhary, Hammad Tufail, et Shahida Hasnain. « IN-SILICO ANALYSIS ». Professional Medical Journal 23, no 02 (10 octobre 2016) : 217–22. http://dx.doi.org/10.29309/tpmj/2016.23.02.1074.

Texte intégral
Résumé :
ntroduction: Different pathogen reducing technologies are being implementedwhich includes S-303. CD-61 is important receptor for clotting. Pathogen reducing agents arebeing studied extensively to probe its effects. Objective: We conducted this study to reviewthe docking of S-303 at CD-61, to look into the effect of S-303 on function of platelets. StudyDesign: This was an observational study. Setting: In-silico study. Period: March 2015 toAugust 2015. Method: The study was carried out in-silico. PDB (Protein data bank) code ofTirofiban bound to CD-61 was 2vdm. CD-61 was docked with Tirofiban using online dockingtools i.e. Patchdock and Firedock. Then, S-303 and CD-61 were also docked. Best dockingposes to active sites of 2vdm were found. Interactions of ligands and CD-61 were obtained.Then comparison of Hydrogen Bonds, Hydrogen Bond Lengths, Hydrophobic bonds of 2vdmmolecule and best poses of docking results were done. Patchdock and Firdock results of bestposes were also analyzed using SPSS-16. Results: The Hydrogen bonds and Hydrogen bondlength and hydrophobic bonds of docking results were compared to 2vdm. 2 best poses wereobtained for docking of tirofiban to CD-61. No docking to active site was observed in Patchdockand firedock for S-303to CD-61. Conclusion: S-303 did not bind to the active site of CD-61. Wecan assume that S-303 doe
Styles APA, Harvard, Vancouver, ISO, etc.
3

Gunamalai, Lavanya, et C. Jaynthy C.Jaynthy. « In Silico Molecular Interaction Analysis Of Type I Collagen Telopeptides With Cyclodextrins ». International Journal of Scientific Research 3, no 8 (1 juin 2012) : 25–27. http://dx.doi.org/10.15373/22778179/august2014/8.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
4

TADA, Yukio, et Mie TOGAWA. « Biomechanical Analysis of Hip Joint in Silico ». Proceedings of Conference of Kansai Branch 2002.77 (2002) : _4–45_—_4–46_. http://dx.doi.org/10.1299/jsmekansai.2002.77._4-45_.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
5

Joy, Amitha. « MLH1 gene : An in silico analysis ». Journal of Computational Biology and Bioinformatics Research 5, no 1 (30 avril 2013) : 1–5. http://dx.doi.org/10.5897/jcbbr12.012.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
6

Barbosa, Aulus Estevão, et Paulo Marinho. « In silico analysis of Eucalyptus thioredoxins ». Genetics and Molecular Biology 28, no 3 suppl (2005) : 539–47. http://dx.doi.org/10.1590/s1415-47572005000400008.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
7

Denomme, Gregory. « In Silico Analysis in Transfusion Medicine ». Vox Sanguinis 83 (août 2002) : 111–13. http://dx.doi.org/10.1111/j.1423-0410.2002.tb05280.x.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
8

Gunn, S., J. R. Hotchkiss et P. Crooke. « In silico analysis of mechanical ventilation ». Journal of Critical Care 21, no 4 (décembre 2006) : 358–59. http://dx.doi.org/10.1016/j.jcrc.2006.10.027.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
9

Florczuk, Patrycja, et Joanna Gruszczyńska. « GENETIC BACKGROUND OF CHONDRODYSPLASIA IN DOMESTIC DOG (CANIS LUPUS FAMILIARIS) – IN SILICO ANALYSIS ». Acta Scientiarum Polonorum Zootechnica 15, no 4 (10 janvier 2017) : 5–14. http://dx.doi.org/10.21005/asp.2016.15.4.01.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
10

Kaplarević, Milica, Marija Gačić, Georgia Karanasiou, Dimitris Fotiadis et Nenad Filipović. « COST-EFFECTIVENESS ANALYSIS OF IN SILICO CLINICAL TRIALS OF VASCULAR STENTS ». Journal of the Serbian Society for Computational Mechanics 16, no 2 (1 décembre 2022) : 105–16. http://dx.doi.org/10.24874/jsscm.2022.16.02.08.

Texte intégral
Résumé :
Today, it takes ten to twelve years on average to complete a clinical trial before a new drug is approved and brought to marktet. Moreover, the evaluation of the efficacy and safety of drugs or devices has been performed in the linear and sequential manner with limited change over the past decade. The InSilc project is an EU funded project (www.insilc.eu) within which the InSilc platform was developed for designing, developing and assessing coronary stents. The InSilc platform contains the following modules: Mechanical Modelling Module, 3D Reconstruction and Plaque Characterization Tool, Deployment Module, Fluid Dynamics Module, Drug Delivery Module, Degradation Module, Myocardial Perfusion Module, Virtual Population Physiology and Virtual Population Database. We analyze the cost of three different in silico scenarios for clinical study. In Scenario 1, two different stent designs are compared according to the ISO standard for in silico mechanical tests. Scenario 2 predicts the stenting outcome for a virtual anatomy where design/material could be changed. Scenario 3 compares two stents using the same virtual anatomies from the Virtual vessel database. Cost-effectiveness analysis was performed for real clinical trials with metallic and BVS stent and in silico clinical trials. It was observed that in silico clinical trials are almost 90 times cheaper than real clinical trials for 1000 patients. In Silico clinical trials will not completely replace real clinical studies but the evidence shows that they can significantly reduce the cost of a real clinical study which will open a new avenue for future hybrid real and in silico clinical trials.
Styles APA, Harvard, Vancouver, ISO, etc.
Plus de sources

Thèses sur le sujet "SILICO ANALYSIS"

1

Chen, Ming. « In silico systems analysis of biopathways ». [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972067272.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
2

Valejev, Najl V. « In silico analysis of signal transduction proteins ». Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432258.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
3

Ferreira, Susana Duarte Barros Lopes. « In silico analysis of regenerating spinal cord transcriptomes ». Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/19034.

Texte intégral
Résumé :
Mestrado em Biomedicina Molecular
As lesões na medula espinal são uma desordem neurológica comum com um impacto significativo na sociedade moderna do ponto de visto físico, psicosocial e socioeconómico. Apesar de vários vertebrados serem capazes de regenerar lesões do sistema nervoso central, nomeadamente da medula espinal (ex. Rã, Peixe-zebra, Salamandra), está bem estabelecido que os seres humanos, e outros mamíferos adultos, não o conseguem fazer. Como tal, em consequência de lesões traumáticas no cérebro ou medula espinal, há incapacidade dos axónios crescerem extensivamente no tecido lesado. No entanto, um estudo importante realizado no virar do século por Ramón y Cajal, comprovou que a incapacidade das fibras nervosas regenerarem “deriva de condições externas, da presença ou ausência de fatores auxiliares que são indispensáveis para o processo regenerativo”, trazendo assim esperança que a neuroregeneração possa ser alcançada por modulação de condições celulares e moleculares. Esta dissertação tem como objetivo adquirir uma melhor e mais extensa compreensão dos genes e processos fisiológicos que são cruciais durante a regeneração da medula espinal, usando estudos de expressão genómica de modelos regenerativos, tais como Xenopus laevis, Xenopus tropicalis e Danio rerio, estabelecendo-se simultaneamente um paralelismo com os respetivos ortólogos humanos com o objetivo de encontrar genes candidatos no genoma humano passíveis de serem modulados com vista a alterar o estatuto não-regenerativo dos mamíferos adultos.
Spinal cord injuries are a common neurologic disorder that have devastating impacts on modern society, be it from physical, psychosocial, or socioeconomic point of view. Although many small vertebrates are capable of regenerating lesions to the central nervous system, namely the spinal cord, (e.g. frog, zebrafish, salamander) it is well established that humans and other adult mammals cannot. As so, failure of axons to grow extensively through damaged central nervous system (CNS) tissues is a common consequence of injury to the brain and spinal cord on adult mammals. However, an important study made at the turn of the century by Ramón y Cajal, proved that the failure of central fibers to regrow “derives from external conditions, the presence or absence of auxiliary factors that are indispensable to the regenerative process”, thus bringing hope that neuroregeneration can be achieved by modulating cellular and molecular conditions. Through this dissertation, we aim to get a better understanding of the involvement of the genes and physiological processes that are crucial during regeneration of the spinal cord, using genome wide expression studies of regenerative models such as Xenopus laevis, Xenopus tropicalis, and Danio rerio, while drawing parallel to its human orthologues. Being our goal to find perfect gene candidates in the human genome that are predictably capable of being modulated so we can alter the non-regenerative status of the adult mammals.
Styles APA, Harvard, Vancouver, ISO, etc.
4

Bassot, Claudio. « In silico analysis of membrane transport/permeability mechanisms ». Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425730.

Texte intégral
Résumé :
Lipid membranes are a fundamental component of living cells, mediating the physical separation of intracellular components from the external environment, as well as the different cellular organelles from cytoplasm. Transmembrane transport proteins confer permeability to lipid membranes, which is essential for nutrient translocation and energy metabolism. Crystallography of transmembrane proteins is a particularly challenging problem. Due to their natural localization and chemical properties only a limited number of structures are to date available at atomic resolution. In silico analysis can be successfully applied to address the structure and to propose testable models of transporters and pores and of their function. My PhD work focused on two main models: Pendrin (SLC26A4) and the Permeability Transition Pore (PTP). These two systems allowed me to investigate different membrane types and permeation mechanisms, i.e. the plasma membrane-specific anion exchange (SLC26A4) and the inner mitochondrial membrane (IMM) unselective PTP. Pendrin mutations are estimated to be the second most common genetic cause of human deafness, but a precise 3D structure of the protein is still missing. Aim of my work was to obviate the absence of structural information for pendrin transmembrane domain and to give a functional explanation for mutations collected in the MORL Deafness Variation Database. The human pendrin 3D model was inferred by homology with SLC26Dg and then validated analyzing the surface distribution of hydrophobic residues. The resulting high quality model was used to map 147 pathogenic human mutations. Three mutation clusters were found, while their localization suggested an innovative 14 transmembrane domain structure for pendrin. The nature of PTP has long remained a mystery. In 2013 Giorgio et. al. suggested dimers of F1FO (F)-ATP synthase to form the pore, however the exact PTP composition and how can a pore form from the energy-conserving enzyme is still matter of debate. PTP opening is triggered by an increased Ca2+ concentration in the mitochondrial matrix, and is favored by oxidative stress. To shed light on PTP function, I investigated the effect of Ca2+ binding to the Me2+ binding site of the F1 domain of F-ATP synthase through molecular dynamics (MD) simulations. A similar approach was also applied to the F-ATP synthase β subunit mutation T163S, which alters the relative affinity for Mg2+ and Ca2+. Experimental data show that Ca2+ binding stiffens the complex structure and that the T163S mutation induces resistance to PTP opening. Further, catalytic site rearrangement induced from different ion occupancy, as well as the mutation T163S, yields relevant variation of the interaction between F1 domain and OSCP subunit. I suggest that an unstructured loop between residues 82-131 of the β subunit transmits the structural rearrangement originated into catalytic site to the OSCP subunit and then to the inner membrane through the rigid lateral stalk. The critical role emerging for OSCP in the PTP regulation opens two parallel questions, i.e. (i) how the OSCP-mediated opening signal is transmitted to the trans-membrane region and (ii) what are the transmembrane PTP components. Variation in pore conductivity among species suggested that the putative pore-forming subunits may be different in different species. Sequence alignment was performed for all the subunits of F-ATP synthase, but we mainly focused on subunits e, g and b due to their localization in the complex and sequence conservation. Specific mutations affecting F-ATP synthase were collected and their functional effect is currently under analysis. In parallel, the presence and features of e, g and f subunits across eukaryotes was investigated by mean of phylogenetic analysis. Protein homologues of these specific subunits were found to be widespread in eukaryotes from yeast to plants while we found that Oomycetes lack subunits e and g and green algae subunit e. This observation suggest an ancient evolution for the F-ATP synthase dimerization subunits and possibly for the PTP. Further analysis and experimental validation are planned to clarify this aspect.
Le membrane lipidiche sono una componente fondamentale delle cellule viventi, separano fisicamente le componenti intracellulari dall’ambiente esterno e i diversi organelli del citoplasma. Le proteine di trasporto conferiscono permeabilità alle membrane lipidiche, proprietà essenziale per la traslocazione di nutrienti e la conservazione dell’energia. La cristallografia di proteine transmembrana è problematica a causa della loro localizzazione e proprietà chimiche, e solo un numero piuttosto ridotto di strutture è disponibile. L’analisi in silico può essere applicata con successo per investigare le strutture e il funzionamento proporre modelli testabili di trasportatori e delle loro funzioni. Il lavoro del mio dottorato sì è focalizzato su due modelli: la pendrina (SLC26A4) e il poro di transizione di permeabilità (PTP). Questi due sistemi proteici mi hanno permesso di studiare due differenti tipi di membrana e meccanismi di permeabilità: la membrana plasmatica con scambio specifico di anioni (SLC26A4) e la membrana interna mitocondriale con la permeabilità non selettiva mitocondriale (PTP). Le mutazioni della pendrina sono stimate essere la seconda causa genetica più comune della sordità umana, ma la struttura della proteina non è stata ancora determinata. Scopo del mio lavoro è stato quello di sopperire all’assenza di informazioni strutturali per il dominio transmembrana della pendrina e di dare una spiegazione funzionale per le mutazioni raccolte nel MORL Deafness Variation Database. Il modello 3D della pendrina è basato sull’omologia con SLC26Dg (3) ed è stato validato analizzando la distribuzione sulla superfice dei residui idrofobici. L’alta qualità risultante dal modello è stata usata per mappare 147 mutazioni patologiche umane. Tre cluster di mutazioni sono stati trovati e la loro localizzazione suggerisce per pendrina un innovativa struttura a 14 domini transmembrana. Anche la natura del PTP è rimasta a lungo misteriosa. Nel 2013 Giorgio et al. hanno suggerito che i dimeri di F1FO (F)-ATP sintasi formino il poro, tuttavia l’esatta composizione e il modo in cui il poro di transizione si possa formare è ancora materia di dibattito. L’apertura del PTP è innescata da un aumento della concentrazione di Ca2+ nella matrice mitocondriale ed è favorita dallo stress ossidativo. Per fare luce sul funzionamento del PTP ho studiato l’effetto del legame del Ca2+ al sito per i cationi divalenti (Me2+) nel dominio F1 attraverso la dinamica molecolare (MD). Un approccio simile è stato anche applicato alla mutazione T163S, che fa variare l’affinità relativa per Mg2+ e Ca2+. I dati sperimentali mostrano come la mutazione induca resistenza all’apertura del PTP. La MD ha dimostrato come il legame del Ca2+ irrigidisca la struttura del complesso. Il riarrangiamento del sito catalitico indotto dai differenti ioni che lo occupano, così come la mutazione T163S, causa rilevanti variazioni delle interazioni tra il dominio F1 e la subunità OSCP. Suggerisco che un loop non strutturato tra i residui 82-131 della subunità β trasmetta il riarrangiamento strutturale originato nel sito catalitico a OSCP e quindi alla membrana interna attraverso il rigido stalk laterale. Il ruolo critico che emerge per OSCP nella regolazione del PTP apre due domande collegate: (i) come il segnale di apertura mediato da OSCP venga trasmesso alla regione trans-membrana e (ii) quali siano i componenti transmembrana del PTP. Le variazioni di conduttanza del poro osservate in specie diverse suggeriscono che le subunità che formano il canale debbano avere delle differenze significative. E’ stato prodotto un allineamento di sequenze per tutte le subunità della F-ATP sintasi. I risultati preliminari ci hanno spinto a focalizzarci sulle subunità e, g e b a causa della loro localizzazione e conservazione di sequenza. Basandomi sugli allineamenti multipli ho suggerito mutazioni puntiformi per testare l’importanza di specifici residui ai fini dell’apertura del poro. In parallelo la presenza delle subunità e e g tra gli eucarioti è stata indagata attraverso un analisi filogenetica. Proteine omologhe di queste specifiche subunità sono presenti in tutti gli eucarioti: dai lieviti alle piante, tuttavia gli Oomiceti sono risultati mancanti delle subunità e e g e le alghe verdi della subunità e. Questi risultati suggeriscono un’origine antica per le subunità di dimerizzazione della F-ATP sintasi e probabilmente anche del PTP. Per chiarire questo aspetto saranno necessarie ulteriori analisi e verifiche sperimentali.
Styles APA, Harvard, Vancouver, ISO, etc.
5

Bellora, Pereyra Nicolás. « In silico analysis of regulatory motifs in gene promoters ». Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7202.

Texte intégral
Résumé :
Regulation of gene transcription is a complex process involving many different proteins, some of which bind in a sequence-specific manner to DNA motifs in the gene promoter. The need to maintain specific interactions between transcription factors and proteins involved in the RNA polymerase II complex is expected to impose constrains on the relative position and spacing of the interacting DNA motifs. The present work includes the development of a novel approach to identify motifs that show a preferential location in DNA sequences and the implementation of a public web application called PEAKS. We investigated if the arrangement and nature of the most common motifs depended on the breath of expression of the gene. We found differences that serve to illustrate that many key specific regulatory signals may be present in the proximal promoter region in mammalian genes. We also apply other methods for the identification of specific transcription factors (TFs) involved in the co-regulation of a set of genes. Data from experimentally-verified transcription factors binding sites (TFBSs) support the biological relevance of our findings.
La regulació de la transcripció dels gens és un procés complex que implica moltes proteïnes diferents, algunes de les quals s'unexien a motius específics d'ADN localitzats a la regió promotora dels gens. S'espera que la necessitat de mantenir les interaccions específiques entre els factors de transcripció i les proteïnes implicades en el complex de la ARN polimerasa II imposi limitacions en la posició relativa i l'espaiat dels motius d'interacció amb l'ADN. La feina presentada en aquesta tesi inclou el desenvolupament d'un nou metode per l'identificació de motius que mostren una localització preferencial en seqüències d'ADN i l'implementació d'una aplicació web pública anomenada PEAKS. Hem investigat si la col·locació i la naturalesa de la majoria dels motius comuns depen del rang d'expresió del gen. Hem trobat diferències que serveixen per il·lustrar el fet que moltes senyals clau de regulació gènica poden estar presents en la regió proximal del promotor dels gens de mamífers. També hem aplicat altres mètodes per a l'identificació de factors de transcripció (TFs) específics involucrats en la co-regulació d'un grup de gens. Dades de llocs d'unio dels TFs (TFBSs) verificats experimentalment recolzen la rellevància biològica dels nostres resultats.
Styles APA, Harvard, Vancouver, ISO, etc.
6

Behera, Jyoti, et Aruna Kilaru. « Comparative in Silico Analysis of WRINKLED1 Paralogs in Angiosperms ». Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7723.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
7

Behera, Jyoti, Shina Bhatia et Aruna Kilaru. « Comparative in Silico Analysis of WRINKLED1 Paralogs in Angiosperms ». Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7724.

Texte intégral
Résumé :
WRINKLED 1(WRI1), a member of AP2/EREBP class of transcription factors regulates carbon allocation between glycolytic and fatty acid biosynthetic pathway. Additionally, among the four WRI1 paralogs in Arabidopsis, WRI3 and 4 but not WRI2, are also able to increase fatty acid content in different tissues. While the role of WRI1 is well established in seeds, the potential or WRI1 or its paralogs as master regulators in oilrich nonseed tissues is poorly understood. Recent transcriptome studies of avocado (Persea americana) mesocarp revealed that the ortholog of WRI2, along with WRI1 and WRI3 was highly expressed during oil accumulation.Through transient expression assays, wefurther demonstrated thatbothPaWRI1 andPaWRI2 can accumulate oil in tobacco leaves. We conducted a comprehensive and comparative in silico analysis of WRI paralogs from a dicot, monocot and a basal angiosperm to identify distinct features associated with function. These data provide insights into the possible evolutionary changes in WRI1 homologs and allow for identification of new targets to enhance oil biosynthesis in diverse tissues.
Styles APA, Harvard, Vancouver, ISO, etc.
8

Azevedo, Ana do Carmo Ramalho Moreira. « Familial amyloid polyneuropathy : TTR sequencing and "in silico" analysis ». Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15608.

Texte intégral
Résumé :
Mestrado em Biomedicina Molecular
Familial amyloid polyneuropathy (FAP) or paramiloidosis is an autosomal dominant neurodegenerative disease with onset on adult age that is characterized by mutated protein deposition in the form of amyloid substance. FAP is due to a point alteration in the transthyretin (TTR) gene and until now more than 100 amyloidogenic mutations have been described in TTR gene. FAP shows a wide variation in age-at-onset (AO) (19-82 years, in Portuguese cases) and the V30M mutation often runs through several generation of asymptomatic carriers, before expressing in a proband, but the protective effect disappear in a single generation, with offspring of late-onset cases having early onset. V30M mutation does not explain alone the symptoms and AO variability of the disease observed in the same family. Our aim in this study was to identify genetic factors associated with AO variability and reduced penetrance which can have important clinical implications. To accomplish this we genotyped 230 individuals, using a directautomated sequencing approach in order to identify possible genetic modifiers within the TTR locus. After genotyping, we assessed a putative association of the SNPs found with AO and an intensive in silico analysis was performed in order to understand a possible regulation of gene expression. Although we did not find any significant association between SNPs and AO, we found very interesting and unreported results in the in silico analysis since we observed some alterations in the mechanism of splicing, transcription factors binding and miRNAs binding. All of these mechanisms when altered can lead to dysregulation of gene expression, which can have an impact in AO and phenotypic variability. These putative mechanisms of regulation of gene expression within the TTR gene could be used in the future as potential therapeutical targets, and could improve genetic counselling and follow-up of mutation carriers.
A Polineuropatia amiloidótica familiar (FAP) ou paramiloidose é uma doença neurodegenerativa autossómica dominante com início na vida adulta sendo caracterizada pela deposição da proteína mutada na forma de substância amilóide. A FAP é devida a uma mutação pontual no gene transtirretina (TTR) e até agora mais de 100 mutações amiloidogénicas foram descritas neste gene. A FAP apresenta uma grande variação na idade de início (AO) (19-82 anos, nos casos portugueses) e a mutação V30M pode segregar através de várias gerações de portadores assintomáticos, antes de se expressar num probando. No entanto, este efeito protetor pode desaparecer numa única geração, com os filhos de casos tardios a apresentarem um início precoce. A mutação V30M não explica por si só os sintomas e a variabilidade da AO observada dentro de uma mesma família. O nosso objetivo neste trabalho foi identificar fatores genéticos associados com a variabilidade da AO e a penetrância reduzida. De modo a cumprir este objetivo genotipámos 230 doentes, por sequenciação automática, para identificar possíveis modificadores genéticos dentro do locus da TTR. Após a genotipagem, investigamos uma possível associação dos SNPs encontrados com a AO e realizamos uma intensiva análise in silico de modo a perceber uma possível regulação da expressão génica. Apesar de não termos encontrado nenhuma associação entre os SNPs e a AO, encontrámos resultados não descritos e muito interessantes na análise in silico dado termos observado algumas alterações a nível do mecanismo de splicing, ligação de fatores de transcrição e ligação de miRNAs. Todos estes mecanismos quando alterados podem levar à desregulação da expressão do gene, o que pode ter um impacto na AO e variabilidade fenotípica. Estes mecanismos hipotéticos da regulação da expressão génica no gene da TTR podem ser úteis para no futuro serem aplicados como potenciais alvos terapêuticos, beneficiando o aconselhamento genético e o follow-up dos portadores da mutação.
Styles APA, Harvard, Vancouver, ISO, etc.
9

Huang, Yi. « In silico analysis of a novel human coronavirus, coronavirus HKU1 ». Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39793825.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
10

Saeed, Hanaa. « «In planta» and «in silico» analysis of soybean lectin promoters ». Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18806.

Texte intégral
Résumé :
Soybean seed lectin, Le1, is specifically located in seeds of soybean, Glycine max, (L.) Merr., due to its promoter. Gene homologues of Le1 were previously identified as possibly located in other parts of soybean. We cloned two novel promoters from these genes, and show that they drive reporter gene expression in transgenic Arabidopsis. A total of 1.3kb was isolated from each of the Le2 and Le3 5' promoter regions and fused with the GUS reporter gene. A previously cloned Le1 5' promoter was used as a control and the constructs were introduced into Arabidospis. GUS expression in transformed plants reveals that GUS driven by Le3 is found predominantly in vegetative tissues whereas GUS driven by Le2 show low expression in all tissues examined. The expression patterns resulting from the three different lectin promoters are distinct and consistent with regulatory motifs computationally identified in the sequences.
Chez le soja (Glycine max), le promoteur du gene lectine Le1 dirige l'expression spécifique dans les graines. Des homologues de Le1 existent dans le genome du soja et sont exprimées ailleurs dans la plante. Nous avons isolé deux promoteurs de ces homologues de lectine, et décrivons le patron d'expression qu'ils dirigent. Un total de 1.3 kilobase des regions 5' des promoteurs, en amont du gène, a été isolé pour chacune des copies Le2 et Le3, et fusionné avec le gène rapporteur GUS. Le promoteur de Le1 étant déjà connu, il sert de controle. L'Arabidopsis transformée avec ces constructions, montre que le promoteur de Le3 dirige l'expression dans les tissues végétatifs, tandis que le promoteur de Le2 procure un niveau minimal d'expression dans tous les tissus examinés. De plus, des analyses bioinformatiques identifient des motifs spécifiques dans les sequences de promoteurs qui confirment les patrons d'expression que nous avons démontrés.
Styles APA, Harvard, Vancouver, ISO, etc.
Plus de sources

Livres sur le sujet "SILICO ANALYSIS"

1

Center, Lewis Research, dir. Stability and rheology of dispersions of silicon nitride and silicon carbide. [Cleveland, Ohio] : National Aeronautics and Space Administration, 1987.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
2

Ampian, Sarkis G. Crystalline silica overview : Occurrence and analysis. Washington, D.C : U.S. Dept. of the Interior, Bureau of Mines, 1992.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
3

Trust, Western Australian Silicon, et Maunsell & Partners., dir. Western Australian Silicon Project. [W.A.] : Maunsell & Partners, 1986.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
4

International, ASTM, dir. Silica and associated respirable mineral particles. West Conshohocken, PA : ASTM International, 2014.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
5

United States. National Aeronautics and Space Administration., dir. Stress and efficiency studies in EFG. Waltham, Mass : Mobil Solar Energy Corp., 1987.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
6

Jet Propulsion Laboratory (U.S.), dir. Stress and efficiency studies in EFG : Quarterly progress report, subcontract no. 956312, covering period October 1, 1984 - December 31, 1984. Waltham, Mass : Mobil Solar Energy Corp., 1985.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
7

United States. National Aeronautics and Space Administration, dir. Stress and efficiency studies in EFG : Quarterly progress report ... covering period January 1, 1985 to March 31, 1985. Waltham, Mass : Mobil Solar Energy Corp., 1985.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
8

Adachi, Sadao. Properties of semiconductor alloys : Group-IV, III-V and II-VI semiconductors. Chichester, West Sussex, U.K : Wiley, 2009.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
9

Properties of semiconductor alloys : Group-IV, III-V and II-VI semiconductors. Chichester, West Sussex, U.K : Wiley, 2009.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
10

Ned, Tenekedjiev, Thomas Susan P et American Foundrymen's Society, dir. Microstructures and thermal analysis of strontium-treated aluminum-silicon alloys. Des Plains, Ill : American Foundrymen's Society, 1995.

Trouver le texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
Plus de sources

Chapitres de livres sur le sujet "SILICO ANALYSIS"

1

Yu, Bing, et Changbin Zhang. « In Silico PCR Analysis ». Dans Methods in Molecular Biology, 91–107. Totowa, NJ : Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-176-5_6.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
2

Bolívar, Julio, Reinhard Hehl et Lorenz Bülow. « In Silico Expression Analysis ». Dans Methods in Molecular Biology, 247–57. New York, NY : Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6396-6_16.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
3

Dovrolis, Nikolas. « In Silico Metagenomics Analysis ». Dans Gut Microbiome-Related Diseases and Therapies, 29–39. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-59642-2_2.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
4

Hone, Andrew, et Hugo van den Berg. « Mathematical Analysis of Artificial Immune System Dynamics and Performance ». Dans In Silico Immunology, 351–74. Boston, MA : Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-39241-7_17.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
5

Woodrow, Ian E. « Flux Control Analysis of the Rate of Photosynthetic CO2 Assimilation ». Dans Photosynthesis in silico, 349–60. Dordrecht : Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9237-4_15.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
6

Paris, Margot, et Laurence Després. « In Silico Fingerprinting (ISIF) : A User-Friendly In Silico AFLP Program ». Dans Data Production and Analysis in Population Genomics, 55–64. Totowa, NJ : Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-870-2_4.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
7

Zhu, Xin-Guang, et Stephen P. Long. « Can Increase in Rubisco Specificity Increase Carbon Gain by Whole Canopy ? A Modeling Analysis ». Dans Photosynthesis in silico, 401–16. Dordrecht : Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9237-4_17.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
8

Liu, Hanqing, Tim N. Beck, Erica A. Golemis et Ilya G. Serebriiskii. « Integrating In Silico Resources to Map a Signaling Network ». Dans Gene Function Analysis, 197–245. Totowa, NJ : Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-721-1_11.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
9

Pruess, Manuela, Paul Kersey, Tamara Kulikova et Rolf Apweiler. « Databases and Resources for in silico Proteome Analysis ». Dans Methods of Biochemical Analysis, 395–414. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471973165.ch21.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
10

Squazzoni, Flaminio, et Federico Bianchi. « Exploring Interventions on Social Outcomes with In Silico, Agent-Based Experiments ». Dans Texts in Quantitative Political Analysis, 217–34. Cham : Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-12982-7_9.

Texte intégral
Résumé :
AbstractAgent-Based Modeling (ABM) is a computational method used to examine social outcomes emerging from interaction between heterogeneous agents by computer simulation. It can be used to understand the effect of initial conditions on complex outcomes by exploring fine-grained (multiple-scale, spatial/temporal) observations on the aggregate consequences of agent interaction. By performing in silico experimental tests on policy interventions where ex ante predictions of outcomes are difficult, it can also reduce costs, explore assumptions and boundary conditions, as well as overcome ethical constraints associated with the use of randomized controlled trials in behavioral policy. Here, we introduce the essential elements of ABM and present two simple examples where we assess the hypothetical impact of certain policy interventions while considering different possible reactions of individuals involved in the context. Although highly abstract, these examples suggest that ABM can be either a complement or an alternative to behavioral policy methods, especially when understanding social processes and exploring direct and indirect effects of interventions are important. Prospects and critical problems of these in silico policy experiments are then discussed.
Styles APA, Harvard, Vancouver, ISO, etc.

Actes de conférences sur le sujet "SILICO ANALYSIS"

1

Rossinelli, Diego, Yu-Hang Tang, Kirill Lykov, Dmitry Alexeev, Massimo Bernaschi, Panagiotis Hadjidoukas, Mauro Bisson et al. « The in-silico lab-on-a-chip ». Dans SC15 : The International Conference for High Performance Computing, Networking, Storage and Analysis. New York, NY, USA : ACM, 2015. http://dx.doi.org/10.1145/2807591.2807677.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
2

L., Yeo S., Shazilah K., Suhaila S., Abu Bakar F. D. et Murad A. M. A. « In-silico analysis of Aspergillus niger beta-glucosidases ». Dans THE 2014 UKM FST POSTGRADUATE COLLOQUIUM : Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2014 Postgraduate Colloquium. AIP Publishing LLC, 2014. http://dx.doi.org/10.1063/1.4895257.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
3

Spanu, Michele, et Matteo Bruno Lodi. « In silico analysis of farmlands disinfection using microwave ». Dans 2017 International Applied Computational Electromagnetics Society Symposium - Italy (ACES). IEEE, 2017. http://dx.doi.org/10.23919/ropaces.2017.7916419.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
4

Arshad, Abida, Rashda Abbasi, Christian MK Sieber, Muhammad Arshad et Nafees Ahmad. « In silico analysis of mutations in PITX3 gene ». Dans 2014 8th International Conference on Systems Biology (ISB). IEEE, 2014. http://dx.doi.org/10.1109/isb.2014.6990430.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
5

Mundayoor, Sathish. « Session details : In silico analysis in biomedical research ». Dans ISB '10 : International Symposium on BioComputing. New York, NY, USA : ACM, 2010. http://dx.doi.org/10.1145/3250321.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
6

Abreu, Carlos, Francisco Miranda et Paula Felgueiras. « Towards patient-specific carbohydrate counting accuracy : An in silico study ». Dans INTERNATIONAL CONFERENCE OF NUMERICAL ANALYSIS AND APPLIED MATHEMATICS ICNAAM 2020. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0081330.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
7

Timkin, Pavel, E. Timofeev, A. Chupalov et Evgeniy Borodin. « ANALYSIS AND SELECTION OF LIGANDS FOR TRPM8 USING HARD DOCKING AND MACHINE LEARNING ». Dans XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9b233509.17835494.

Texte intégral
Résumé :
In this work, using the in-silico experiment modeling method, the receptor and its ligands were docked in order to obtain the data necessary to study the possibility of using machine learning and hard intermolecular docking methods to predict potential ligands for various receptors. The protein TRPM8 was chosen, which is a member of the TRP superfamily of proteins and its classic agonist menthol as a ligand. It is known that menthol is able to bind to tyrosine 745 of the B chain. To carry out all the manipulations, we used the Autodock software and a special set of graphic tools designed to work with in silico models of chemicals. As a result of all the manipulations, the menthol conformations were obtained that can bind to the active center of the TRPM8 receptor.
Styles APA, Harvard, Vancouver, ISO, etc.
8

Schoenrock, Andrew, Daniel Burnside, Houman Moteshareie, Alex Wong, Ashkan Golshani, Frank Dehne et James R. Green. « Engineering inhibitory proteins with InSiPS : the in-silico protein synthesizer ». Dans SC15 : The International Conference for High Performance Computing, Networking, Storage and Analysis. New York, NY, USA : ACM, 2015. http://dx.doi.org/10.1145/2807591.2807630.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
9

Mustafha, Siti Mardhiah, Abdul Munir Abdul Murad, Nor Muhammad Mahadi, Shazilah Kamaruddin et Farah Diba Abu Bakar. « In silico analysis of subtilisin from Glaciozyma antarctica PI12 ». Dans THE 2015 UKM FST POSTGRADUATE COLLOQUIUM : Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4931246.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
10

HANAI, TOSHIHIKO, et TSUTOMU TACHIKAWA. « QUANTITATIVE ANALYSIS OF CHEMILUMINESCENCE INTENSITY AND TOXICITY IN SILICO ». Dans Proceedings of the 13th International Symposium. WORLD SCIENTIFIC, 2005. http://dx.doi.org/10.1142/9789812702203_0094.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.

Rapports d'organisations sur le sujet "SILICO ANALYSIS"

1

Lazzaro, John, et John Wawrzynek. Silicon Models for Auditory Scene Analysis. Fort Belvoir, VA : Defense Technical Information Center, janvier 1995. http://dx.doi.org/10.21236/ada327239.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
2

Pawlak, John. D0 Silicon Upgrade : Ladder Removal Stress Analysis. Office of Scientific and Technical Information (OSTI), octobre 1994. http://dx.doi.org/10.2172/1033317.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
3

van der Werf, I., F. Palmisano, Raffaele De Leo et Stefano Marrone. Chemical Analyses of Silicon Aerogel Samples. Office of Scientific and Technical Information (OSTI), avril 2008. http://dx.doi.org/10.2172/955880.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
4

Haney, R. E., A. Neugroschel, K. Misiakos et F. A. Lindholm. Frequency-domain transient analysis of silicon solar cells. Office of Scientific and Technical Information (OSTI), mars 1989. http://dx.doi.org/10.2172/6346849.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
5

Rucinski, Russ. D0 Silicon Upgrade : D-Zero Assembly Hall ODH Analysis. Office of Scientific and Technical Information (OSTI), mars 1997. http://dx.doi.org/10.2172/1033268.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
6

Rucinski, Russ. D0 Silicon Upgrade : Lower Cleanroom Roof Quick Load Analysis. Office of Scientific and Technical Information (OSTI), novembre 1995. http://dx.doi.org/10.2172/1033291.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
7

Wilmarth, W. R. Silicon Analysis of Tank 8F and Tank 40H Turbidity Samples. Office of Scientific and Technical Information (OSTI), avril 2001. http://dx.doi.org/10.2172/779685.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
8

Anderson, Brent. D0 Silicon Upgrade : A Layer Drawbridge Access : Platforms Calculations and Analysis. Office of Scientific and Technical Information (OSTI), mai 2000. http://dx.doi.org/10.2172/1481382.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
9

Underwood, J. H., P. J. Cote et G. N. Vigilante. Thermomechanical and Fracture Analysis of Silicon Carbide in Cannon Bore Applications. Fort Belvoir, VA : Defense Technical Information Center, juin 2003. http://dx.doi.org/10.21236/ada416282.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
10

Ratzmann, Paul M. D0 Silicon Upgrade : Thermal Analysis of the D0 Double Sided Ladders. Office of Scientific and Technical Information (OSTI), juillet 1996. http://dx.doi.org/10.2172/1033276.

Texte intégral
Styles APA, Harvard, Vancouver, ISO, etc.
Vous pouvez également être intéressé par les bibliographies sur le sujet « SILICO ANALYSIS » pour d’autres types de sources :
Articles de revues Thèses Livres
Nous offrons des réductions sur tous les plans premium pour les auteurs dont les œuvres sont incluses dans des sélections littéraires thématiques. Contactez-nous pour obtenir un code promo unique!

Vers la bibliographie