Thèses sur le sujet « SIGNALLING MECHANISM »
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Promel, Simone. « Investigating the molecular mechanism of latrophilin signalling ». Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533843.
Texte intégralLewis, Miranda Faye. « Dissecting the molecular mechanism of toll signalling ». Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707987.
Texte intégralNyamay'Antu, Alengo. « Elucidating the mechanism of angiopoeitin-mediated Tie2 signalling ». Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/elucidating-the-mechanism-of-angiopoeitinmediated-tie2-signalling(4269f3c3-fc71-455d-ae5b-4bc47dda78ca).html.
Texte intégralWong, Tin Lok. « Mechanism of action of silicon in cell signalling ». Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709339.
Texte intégralSeymour, Lyndsey A. « Characterising the signalling mechanism of the mTOR-dependent phosphatase ». Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55115/.
Texte intégralBryan, Andrea. « A study of electrophysiological and pathological signalling mechanism in the Xenopus laevis oocyte ». Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267991.
Texte intégralJethwa, Susanna Anjali. « Exosomes : vesicular carriers of autotaxin, a novel mechanism of LPA signalling ». Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608189.
Texte intégralJopling, Helen Mary. « A Mechanism for VEGFR2 Trafficking, Signalling and Degradation in Human Endothelial Cells ». Thesis, University of Leeds, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515561.
Texte intégralMcDowell, Natasha. « The mechanism of long-range signalling between cells of the Xenopus embryo ». Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624744.
Texte intégralMcLaughlin, Declan. « Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity ». Thesis, Queen's University Belfast, 2014. https://pure.qub.ac.uk/portal/en/theses/investigation-into-the-mechanism-of-nox2-nadph-oxidasedependent-signalling-in-doxorubicin-cardiotoxicity(4250d47c-175c-48d9-bc79-7d1a5ab01443).html.
Texte intégralThomas, Paul William. « Long-distance systemic irradiance signalling : the extent, nature and mechanism in vascular angiosperms ». Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421164.
Texte intégralWardyn, J. D. « Investigating the molecular mechanism of crosstalk between NF-κB and Nrf2 signalling pathways ». Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3000015/.
Texte intégralMeehan, B. « Bacteria-induced Wnt signalling as a mechanism for malignant development in the intestinal epithelium ». Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3012547/.
Texte intégralBates, Katharine Jane. « The neuroplastin cell adhesion molecules : activation of signalling pathways and characterization of the homophilic binding mechanism ». Thesis, Royal Holloway, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499983.
Texte intégralGruber, Claudia. « Investigation into the regulatory mechanism of BRCA2 stability ». Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e69ab649-f955-48d2-a7c5-48b65f15df45.
Texte intégralBritton, G. « Proteomic analysis of Vascular Endothelial Growth Factor (VEGF) signalling : studies of the mechanism of VEGF-induced Heat Shock Protein 27 phosphorylation and its role in endothelial cell signalling and function ». Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19979/.
Texte intégralSéquaris, Gilles Frédéric Brice [Verfasser], Siegfried [Akademischer Betreuer] Roth et Angelika A. [Akademischer Betreuer] Noegel. « Molecular mechanism of Indian Hedgehog signalling in human sebocytes / Gilles Frédéric Brice Séquaris. Gutachter : Siegfried Roth ; Angelika A. Noegel ». Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/1038227216/34.
Texte intégralLo, William Wing-Yan. « A study of receptor-mediated phosphoinositide signalling mechanism using the human pituitary cell line flow 9000 as a model system ». Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328913.
Texte intégralWoolson, Hayley D. « Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines : IL-6 and leptin in endothelial cells ». Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/648/.
Texte intégralSalvi, Michele [Verfasser], Christian [Akademischer Betreuer] Griesinger, Blanche [Gutachter] Schwappach et Groot Bert [Gutachter] De. « Structural Studies on Transmembrane Signalling Mechanism of Histidine Kinase CitA / Michele Salvi ; Gutachter : Blanche Schwappach, Bert De Groot ; Betreuer : Christian Griesinger ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1201884659/34.
Texte intégralPhan, Michael. « Viral Sensitizers Potentiate the Infection of Cancer Cells Via NF-kB ». Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40524.
Texte intégralSymington, Hannah Lucy. « Mechanism of IL-2 mediated BACH2 regulation in the control of Human naive B cell differentiation into plasma cells ». Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B009.
Texte intégralThe terminal differentiation of B cells, which takes places within germinal centres of secondary lymphoid organs, is the ultimate step of a T cell dependent response and results in the generation of long-lived plasma cells (PCs) that secrete protective, antigen-specific, high-affinity antibodies as part of adaptive immunity. The transition of a naive B cell into a PC is governed by a well-characterised gene regulatory network and is heavily influenced by the integration of externally received signals, including BCR-antigen binding and T cell help, such as cytokines which guide B cell fate. The early IL-2 priming of human primary activated B cells triggers PC differentiation through sustained ERK signalling resulting in the down regulation of B cell transcription factor BACH2. Transient BACH2 repression is sufficient to trigger plasmablast differentiation in the absence of IL-2 suggesting that it acts as a key lock of PC differentiation. Importantly, this enforced BACH2 repression results in the generation of plasmablasts with a lymphoplasmacytic phenotype. The focus of this thesis was to characterise the molecular mechanisms regulating BACH2 expression via the IL-2 ERK transduction pathway. We identify ELK-1 as the mediator of IL-2 ERK induced BACH2 downregulation as it binds to a regulatory enhancer element located within intron 1 of BACH2 instigating its repression and unlocking the PC programme triggering differentiation. The characterisation of this BACH2 enhancer confirms that it is dynamically regulated during PC differentiation and is located within a region targeted for mutation suggesting that it may have a potential role in lymphomagenesis
Gyles, Shan Lindsey. « Intracellular signalling mechanisms in steroidogenesis ». Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269684.
Texte intégralVan, den Bosch Marion T. J. « Signalling mechanisms regulating platelet secretion ». Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685919.
Texte intégralBrumell, John H. « Phosphorylation-dependent signalling mechanisms in human neutrophils ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0018/NQ27612.pdf.
Texte intégralKwan, Yuen-wah, et 關琬樺. « Signalling mechanisms of Epac1-mediated vascular responses ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49618106.
Texte intégralpublished_or_final_version
Pharmacology and Pharmacy
Master
Master of Philosophy
Healey, Eleanor G. « Molecular mechanisms of Repulsive Guidance Molecule signalling ». Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:3ba6699b-7919-47db-a58e-95970e5e8fcf.
Texte intégralFlack, Joshua Edwin. « Mechanisms of molecular switching in the Wnt signal transduction pathway ». Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284206.
Texte intégralTamiya, Shigeo. « Autocrine and paracrine signalling mechanisms in lens cells ». Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365025.
Texte intégralBhangu, P. S. « Vesicular 'pre-synaptic' glutamatergic signalling mechanisms in bone ». Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288814.
Texte intégralSpencer, Gary James. « Glutamate recycling and signalling mechanisms in bone cells ». Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399248.
Texte intégralFiúza, Ulla-Maj. « Mechanisms of regulation of notch signalling in Drosophila ». Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611170.
Texte intégralJenkinson, Stephen. « Molecular mechanisms of lithium action on phosphoinositide signalling ». Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35263.
Texte intégralAmbily, Anju. « Studies of calcium signalling mechanisms in human platelets ». Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/studies-of-calcium-signalling-mechanisms-in-human-platelets(0754e26d-374a-485e-9387-41e074926048).html.
Texte intégralCastello, A. « Regulatory mechanisms of antigen encounter and BCR signalling ». Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1407025/.
Texte intégralOrlando, Giulia. « Molecular mechanisms of ARF regulation in response to DNA damage ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:fde8ab19-bc7f-4ad8-8396-6c5f5f385d34.
Texte intégralKirkeby, Håkon. « In silico Investigation of Possible Mitotic Checkpoint Signalling Mechanisms ». Thesis, Norwegian University of Science and Technology, Department of Mathematical Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-9663.
Texte intégralThe mitotic checkpoint is the major bio-chemical pathway acting to ensure stable genome content in cell division. A delay in chromosome segregation is enforced as long as at least one kinetochore is in lack of proper attachment to the mitotic spindle, something that prevents premature initiation of anaphase and uneven chromosome distribution. The backbone of the mitotic checkpoint control system is established as the production of a wait-anaphase signal at the unattached kinetochores. However, how this signal is able to support a functional checkpoint is unclear. To explore the performance of the wait-anaphase signal in terms of providing the mitotic checkpoint with high fidelity, a mathematical modelling framework is constructed that simulates the spatially distinct production of anaphase inhibitors, their diffusion in the cytoplasm and interference with the anaphase-promoting machinery. The model is used to analyse the performance of several different signalling mechanisms, with emphasis on testing the ability to maintain tight inhibition and allow rapid release of the anaphase promoter.
Atwal, Jasvinder K. « Signalling mechanisms underlying Trk function in neonatal sympathetic neurons ». Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37645.
Texte intégralFirst, I examined the involvement of key signalling motifs on the Trk receptor in mediating neurotrophin-dependent survival and local axon growth. Using recombinant adenoviruses, I expressed the BDNF receptor TrkB, which is not endogenously expressed in SCG neurons, either in wild-type form or mutated at defined effector binding sites. Ectopically expressed wild-type TrkB activated signalling pathways similarly to endogenous TrkA, and supported both neuronal survival and local axon growth in compartmented Campenot chambers. However, TrkB mutated at the Shc-binding site was impaired in its ability to activate PI3-kinase/Akt and MEK/ERK, and was a poor mediator of both neuronal survival and local axon growth. Furthermore, by using pharmacological inhibitors, I found that TrkB-mediated survival and local axon growth required both PI3-kinase and MEK/ERK signalling.
Next, I investigated the contribution of Trk signalling to growth cone maintenance in sympathetic neurons. Acute inhibition of NGF/TrkA signalling rapidly collapsed growth cones, as did inhibition of either PI3-kinase or MEK/ERK. I then asked whether the chemorepellent Sema3F collapsed sympathetic growth cones by inhibiting TrkA-mediated growth signals. Sema3F did not disrupt NGF-induced activation of TrkA, Shc, or PLC-gamma but significantly reduced PI3-kinase and MEK/ERK activation. Furthermore, sustained hyper-activation of PI3-kinase and MEK/ERK partially blocked Sema3F-induced collapse, suggesting that Sema3F acts, at least in part, by inhibiting Trk-dependent pathways.
Together, these data describe the role of Trk signalling in survival, local axon growth, and growth cone maintenance in cultured sympathetic neurons. The Shc-binding site was found to be critical for TrkB-mediated survival and local axon growth. The PI3-kinase and MEK/ERK pathways were found to be important for survival, local axon growth and growth cone maintenance. Furthermore, the chemorepellent Sema3F collapses sympathetic growth cones, at least in part, by interfering with key neurotrophin-induced signalling pathways.
Neve, Joshua Thomas. « Identification of novel regulators and mechanisms of auxin signalling ». Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612611.
Texte intégralCameron, A. L. « Intracellular signalling mechanisms of the unicellular parasite, T.b. brucei ». Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597238.
Texte intégralLahne, Manuela. « Damage-induced signalling mechanisms in the neonatal rat cochlea ». Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444911/.
Texte intégralKemp, Daniel M. « Reporter gene analysis of regulatory mechanisms in cAMP signalling ». Thesis, University of Kent, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310202.
Texte intégralDavies, Clare Charlotte. « Mechanisms of CD40 signalling and apoptosis in carcinoma cells ». Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398887.
Texte intégralJimeÌnez, Luis Albert. « Signalling mechanisms induced by particulate matter in lung cells ». Thesis, Edinburgh Napier University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250084.
Texte intégralLi, Xin. « TRPM2 channel-mediated signalling mechanisms for neuronal cell death ». Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18576/.
Texte intégralGooch, Sophie Louise. « Studies into NOD1 and NOD2 activation and signalling mechanisms ». Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608182.
Texte intégralHsu, Li-Heng. « Signalling mechanisms underlying priming and tolerance of T cells ». Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4263/.
Texte intégralKneeshaw, Sophie. « Molecular mechanisms of redoxin-mediated signalling in plant immunity ». Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/18754.
Texte intégralAlayash, Abdu I. « Hemoglobin-based blood substitutes : redox, signalling and clearance mechanisms ». Thesis, University of Essex, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528868.
Texte intégralSianati, Setareh. « μ-Opioid receptor signalling mechanisms : quantifying bias and kinetics ». Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12794.
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