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VALLETTA, SIMONA. « Recurrent SETBP1 mutations in atypical chronic myeloid leukemia ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50227.
Texte intégralRésumé :
Atypical chronic myeloid leukemia (aCML) is a heterogeneous disorder belonging to the group of myelodysplastic/myeloproliferative (MDS/MPN) syndromes. aCML shares clinical and laboratory features with Chronic Myeloid Leukemia (CML), but it lacks the Philadelphia chromosome and the resulting BCR-ABL fusion gene. This crucial difference with CML points to a different pathogenetic process. Because no specific recurrent genomic or karyotypic abnormalities have been identified in aCML, and the molecular pathogenesis of this disease has remained elusive with a dismal outcome, we performed exome-sequencing of eight aCML patients, in order to identify new possible recurrent mutations. The presence of an identical mutation not previously involved in cancer in two different aCML cases altering SETBP1 gene, prompted us to resequence this particular gene in samples from additional subjects with aCML or other hematological malignancies and in cell lines representative of the most common human solid cancers. SETBP1 mutations were identified only in aCML and in the closely related disorders and represents the first gene shown to be enriched and recurrently mutated in aCML. Most SETBP1 mutations were located between codons 858 and 871 causing abrogation of a degron binding site for E3-ubiquitin β-TrCP1 and protection from proteasomal degradation. This causes accumulation of SETBP1 and SET protein, decreased PP2A phosphatase activity and higher proliferation rates. Individuals with SETBP1 mutations had higher white blood cell counts and worse prognosis, indicating SETBP1 as a possible valuable diagnostic tool in the differential diagnosis of MDS/MPN syndromes and their prognosis.
This study increases the knowledge of the mechanisms by which malignancy arises and will have important consequences for the diagnosis, prognosis and treatment of aCML and diseases associated with SETBP1 alterations.
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PERONACI, MARCO. « Characterization of new oncogenes identified through NGS-based analysis of leukemias : SETBP1 and ETS2-ERG ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/144663.
Texte intégralRésumé :
In the past years, the improvements in sequencing technology led to the development of “Next Generation Sequencing” (NGS) technologies. Several NGS approaches exist. Whole genome sequencing (WGS) and whole exome sequencing (WES) allow the identification of genomic alterations such as small insertions/deletions, point mutations and structural variants. Whole transcriptome sequencing (RNA-Seq) permits to quantify gene expression profiles and to detect alternative splicing and fusion transcripts. Recently, by using WES on atypical chronic myeloid leukemia (aCML) samples, our group identified recurrent mutations in SETBP1 gene; also, by using RNA-Seq on acute myeloid leukemia (AML), we identified a new fusion gene: ETS2-ERG. In aCML, SETBP1 mutations disrupt a degron binding site, leading to a decreased protein degradation. This leads to an increased amount of SETBP1 protein interacting with its natural ligand SET, which in turn acts inhibiting the protein phosphatase 2A (PP2A) oncosuppressor. Interestingly, the SETBP1 mutational cluster affected in aCML is highly conserved and the same mutations were also observed in the Schinzel-Giedion syndrome (SGS). However, the inhibition of the PP2A by SET, the only known interactor of SETBP1, does not explain the phenotype of SGS. To further characterize the role of SETBP1 protein, 293 Flp-In isogenic cellular models expressing the empty vector or the wild type (WT) or mutated (G870S) form of SETBP1 were established. In these models SETBP1 was fused with a V5 tag. Chromatin Immunoprecipitation sequencing experiments (Chip-Seq) performed against V5 confirmed the binding of SETBP1 to DNA, both for the WT and G870S forms. In addition, RNA-Seq experiments were performed. The comparison between Chip-Seq and RNA-Seq data has allowed us to identify 130 genes presenting both the binding of SETBP1 to their promoter region and transcriptional upregulation. Together these data suggest a role for SETBP1 as a transcriptional activator. Co-immunoprecipitation (Co-IP) experiments in transiently transfected HEK293T cells coupled with mass spectrometry (MS) analysis were performed to identify potential interactors of SETBP1. MS analysis led to the identification of the host cell factor 1 (HCF1), a component of the SET1/KMT2A COMPASS-like complex. Independent validation by western blot and fluorescence resonance energy transfer (FRET) confirmed the direct binding of HCF1 to SETBP1. Further independent experiments confirmed the Co-Ip of SET1/KMT2A and PHF8 with SETBP1. SET1/KMT2A is a core component of COMPASS-like complex and possesses H3K4 methyltransferase activity, whereas PHF8 possesses H4K20 demethylase activity. Both marks are associated with actively transcribed genes. Taken together, we have shown that SETBP1 protein is able to act as a transcriptional activator recruiting the HCF1/KMT2A/PHF8 complex.
In a previous study, comparing cytogenetic analysis and RNA-Seq to detect chromosomal abnormalities on AML patient samples, a new fusion between the ETS2 and ERG genes was reported. The patient carrying this fusion was affected by acute promyelocytic leukemia (APL) and did not respond to therapy with retinoic acid. The role of the ETS2-ERG fusion is not known. To gain insight about the functional role of ETS2-ERG fusion in APL two cellular models were established. HL-60 and NB-4 cells were stable transfected with retroviral empty vector or with a vector carrying the fusion gene. This vector also carries the GFP as a positive selection marker. HL-60 cells carrying the ETS2-ERG fusion treated with retinoic acid showed a decrease in the expression at membrane level of the differentiation marker CD11b. This suggests that the ETS2-ERG fusion is able to impair the differentiation of APL cells upon retinoic acid treatment. Further experiments are ongoing to confirm the data in the NB4 cellular model.
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KHANDELWAL, PRAVEEN. « Elucidating the oncogenic role of genetic events in BCR-ABL1 positive chronic myeloid leukemia ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/99449.
Texte intégralRésumé :
In hematological myeloid malignancies the accumulation of oncogenic events plays a significant role in disease progression. Therefore, in this work, we studied (i) the mutational landscape in typical chronic myeloid leukemia (CML) patients and (ii) the neoplastic role of Setbp1 mutation in atypical chronic myeloid leukemia (aCML).
1) We evaluated somatic variants in CML patients by Next Generation Sequencing, to study the molecular pathogenesis of cancer. We conducted a mutational analysis on 23 chronic phase BCR-ABL1+ CML patients through exome and RNA sequencing performed on diagnosis samples. A total of 107 non-synonymous variants (range 0-11 per patient) were identified by setting a threshold of mutation frequency >25%, which corresponds to the presence of a heterozygous mutation in >50% of cells, assuming a pure tumoral sample. A positive correlation was observed between number of mutations and patient age, indicating that several events were passenger mutations, being immortalized by the neoplastic transformation. However, when using a newly in-house developed tool (Oncoscore) to weigh the oncogenic potential of each mutation, a significant correlation was observed between the Sokal score and Oncoscore by using linear model statistical analysis. In long term follow-up (>2 years), 21 CML patients achieved complete cytogenetic responses (CCyR) and 2 failed to achieve any cytogenetic response with tyrosine kinase inhibitors. These two patients showed an Oncoscore value of (165.4 ±27.2) which was significantly higher than the one (80.6 ±12.7) in the 21 responding patients. No fusions (other than BCR/ABL1) were identified by RNA Seq, and no chromosomal alterations were observed by using the CEQer software. In conclusion, CML patients at diagnosis carry genetic alterations additional to the BCR/ABL1 fusion, which could be relevant for response to treatment and progression of the disease.
2) We aimed to gain insights into the biological role of Setbp1 mutations found in aCML patients, by invivo genetic manipulation techniques. Recently, by NGS approach, we identified a recurrent SETBP1 missense mutation in aCML patients, associated with poor overall survival. The most frequent SETBP1 mutations identified in various MDS/MPN neoplasms were positioned at D868N, S869G, G870S and I871T. The same mutations identified in myeloid malignancies had previously been observed as de novo recurrent germline mutations responsible for Schinzel-Giedion syndrome. Unfortunately, the biological role of Setbp1 and its activity in leukemic transformation is not exactly known. Therefore, an improved understanding of the molecular mechanism is imperative. So, we applied genetic engineering to construct a conditional knock-in model for dissecting the role of leukemia transforming factors in heterozygous Setbp1G870S mice. For construction, 3 genomic fragments of Setbp1 intron 3 and exons 4 through 6 were subcloned into the conditional replacement vector pDELBOY-3X. The linearised vector was then transfected into murine ES cells. We are currently screening ES cells to identify a correctly targeted clone for blastocyst injection and transplantion into pseudo-pregnant mice. The 1st generation Setbp1WT/floxed mice will express wild type Setbp1 under the control of its endogenous promoter. Thereafter, the expression of Setbp1G870S would be induced in a conditional manner with Cre-mediated recombination. Depending on the type of promoter driving Cre recombinase expression, the mutant allele will be expressed either constitutively (germline) or somatically, and it will be possible to study the oncogenic effects of Setbp1G870S in specific tissues, or in all tissue/cells. Additionally, the molecular interactions and physiological pathways accountable for tumorigenesis and the clonal evolution pattern will be examined by implementing the molecular and functional genomic techniques, which help in better understanding of developing targeted therapies.
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Rediger, Daniel. « Minimizing production setups by optimizing the production setup ». Connect to resource, 2006. http://hdl.handle.net/1811/6493.
Texte intégralRésumé :
Thesis (Honors)--Ohio State University, 2006.Title from first page of PDF file. Document formatted into pages: contains 9 p. Includes bibliographical references (p. ). Available online via Ohio State University's Knowledge Bank.
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Andersson, Joakim, et Jimmy Bertilsson. « SETUP TIME OPTIMIZATION ». Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-23661.
Texte intégralRésumé :
Sammanfattning Emhart Glass AB är världsledande företag inom glasflasktillverkning. De konstruerar automatiserade maskiner som formar glasflaskor. I Sverige finns det två fabriker, en i Örebro och en i Sundsvall. I Örebro tillverkar man främst reservdelar och nya delar till maskinerna medan man i Sundsvall monterar ihop maskinerna. Det finns totalt 15 olika fabriker och kontor över världen med huvudkontor i schweiziska Cham. Eftersom Emhart Glass Örebro har för långa ställtider på några av deras maskiner ska det undersökas hur omställningsarbetet går till i dagsläget och hur omställningsarbetet skiljer sig åt mellan operatörerna. Det ska även undersökas om det finns några möjligheter till förbättringar samt om det i dagsläget finns något standardiserat sätt som operatören borde följa. Ett dokument som beskriver hur ställarbetet ska gå till kommer även att tas fram. Ett utmärkt verktyg för att förkorta ställtiderna i en produktion är SMED-Metoden. Filosofin bakom SMED är att man ska analysera och skilja på inre och yttre ställ. Med inre och yttre ställ menas de som endast kan utföras då maskinen är avstängd resp. de som kan utföras när maskinen är i drift. För att standardisera omställningsarbetet så att samtliga operatörer jobbar på liknande sätt så krävs det att man tar fram en dokumentation över hur arbetet ska gå till. Därför har checklistor tagits fram till operatören. "Checklista - Omställning.xls" är en checklista med syftet att man ska kunna bocka för vilka delar i förberedelserna man gjort inför kommande ställ. Den har tagits fram för att man enkelt ska kunna hålla reda på vilka delar man gjort om man blivit tvungen att jobba med maskinen emellan förberedelserna eller om man slutar sitt skift och lämnar delar av arbetet till nästa operatör. Om samtliga av dessa förbättringar införs kan man förvänta sig en ställtidsreducering på 20,5% vilket motsvarar ca 35min per ställ. Ignorerar man inkörningstiderna och endast kollar på riggningstider kan man se en förbättring på 36,4 %.Abstract Emhart Glass Ltd is a world leader in glass bottle manufacturing. They design automated machines that shape glass bottles. In Sweden there are two factories, one in Örebro and one in Sundsvall. In Örebro they manufacture primarily spare parts and new parts for the machines while they in Sundsvall assemble the machines. There are a total of 15 factories and offices around the world with the headquarter located in Swiss Cham.Since Emhart Glass Örebro has long setup times on some of their machines. This is why we want to identify the current setup process and how the setup process differs between operators. We will also look at whether there are any opportunities for improvement to be made and if they have a standardized way to work. A document that describes how to setup work should be done will also be developed.An excellent tool to shorten the setup time in a production is the SMED method. The philosophy behind SMED is that you should analyze and separate the inner and outer activities. Inner and outer activities mean those activities which can only be performed when the machine is turned off, respectively those activities that can be performed when the machine is in operation. In order to standardize the adjustment process so that all operators are working in a similar way it's required that you make a documentation about how the work should be done. Therefore, checklists been developed to the operator. "Checklista - Omställning.xls" is a checklist with the purpose to be able to check which parts of the preparations they have made before the next setup work. It has been designed to be easy to keep track of what parts you have done if you had to work with the machine between the trial or if you quit your shift and leaving parts of the work to the next operator. If all of these improvements are implemented, we expect a set-up time reduction of 20.5% which corresponds to about 35min per set-up. By ignoring the running time and only check on the setup times, one can see an improvement of 36.4%.
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Bernardo, Heliudson de Oliveira. « Cosmological models from string theory setups / ». São Paulo, 2019. http://hdl.handle.net/11449/183612.
Texte intégralRésumé :
Orientador: Horatiu NastaseResumo: Nesta tese, discutimos três modelos cosmológicos que são baseados direta ou indiretamente em ideias advindas de teoria das cordas. Depois de uma revisão geral de cosmologia em teoria das cordas, um resumo de cosmologia e teoria das cordas é apresentado, com ênfase nos conceitos fundamentais e teóricos. Então descrevemos como o acoplamento camaleônico pode potencialmente afetar as predições de inflação cósmica com campo único, com tratamento cuidadoso dos modos de perturbação cosmológica adiabáticos e de entropia. Além disso uma nova abordagem para a dualidade-T em soluções cosmológicas de supergravidade bosônica é discutida no contexto de teoria dupla de campos. Por fim, propomos uma nova prescrição para o mapa holográfico em cosmologia que pode ser usado para conectar modelos fundamentais de cosmologia holográfica com outras abordagens fenomenológicas.
Doutor
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Yang, Yanchun Bulfin Robert L. « Knapsack problems with setup ». Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Summer/Dissertations/YANG_YANCHUN_31.pdf.
Texte intégral
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Apotsos, Alex. « Setup in the surfzone ». Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42219.
Texte intégralRésumé :
Thesis (Ph. D.)--Joint Program in Applied Ocean Science and Engineering (Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering; and the Woods Hole Oceanographic Institution), 2007.Includes bibliographical references.
Surfzone wave height transformation and wave-breaking-driven increases in the mean sea level (setup) are examined on alongshore-uniform beaches with alongshore homogeneous and inhomogeneous wave forcing. While previously derived models predict wave heights adequately (root-mean-square errors typically less than 20%), the models can be improved by tuning a free parameter or by using a new parameterization based on the deep-water wave height. Based on a sensitivity analysis of the cross-shore momentum balance used to predict setup, a one-dimensional (1-D) model is developed that includes wave rollers and bottom stress owing to the mean offshore-directed flow. The model predicts setup accurately at three alongshore homogeneous field sites, as well as at a site where the incident wave field is alongshore non-uniform, suggesting that setup is driven primarily by the cross-shore (1-D) forcing. Furthermore, alongshore gradients of setup can be important to driving alongshore flows in the surfzone, and the 1-D setup model predicts these gradients accurately enough to simulate the observed flows.
by Alex Apotsos.
Ph.D.
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Yemm, Sean P. « Field Observation of setup ». Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Jun%5FYemm.pdf.
Texte intégralRésumé :
Thesis (M.S. in Meteorology and Physical Oceanography)--Naval Postgraduate School, June 2004.Thesis advisor(s): Edward Thornton. Includes bibliographical references (p. 29-31). Also available online.
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D'Uva, Michael. « Motor Generator Dynamometer Setup ». Thesis, D'Uva, Michael (2013) Motor Generator Dynamometer Setup. Other thesis, Murdoch University, 2013. https://researchrepository.murdoch.edu.au/id/eprint/21902/.
Texte intégralRésumé :
The primary aim of this thesis was the further development and reconstruction of the Motor Generator Dynamometer set up. Once completed, the apparatus is to be used as a learning tool for the engineering students at Murdoch University, demonstrating key concepts of electric machines and their reactions to the change in load conditions. For the mention primary aim the design, construction and commissioning of a load bank had to be adapted to the initial setup to enable the students to alter the connected load. Measurements and control of the apparatus was achieved through National instruments NI 6014 data acquisition unit and National Instruments LabVIEW.
The understanding of the project and the work that had been previously completed was the first stage of the project. Understanding the current system setup including the:
• DAQ system
• AC motor
• DC Generator
The resolution of existing problems was attempted such as overcoming the interference induced by the variable Frequency drive, accurate speed measurement of the machines and calibration of the torque measurement. As the main priority associated with the development of this project was safety for undergraduate students to perform experiments without the risk of being injured. This is why a complete reconstruction of the set up must take place further information can be found in the guidelines and design approaches that have been developed.
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Rondilla, Mark. « Motor generator dynamometer setup ». Thesis, Rondilla, Mark (2017) Motor generator dynamometer setup. Honours thesis, Murdoch University, 2017. https://researchrepository.murdoch.edu.au/id/eprint/35836/.
Texte intégralRésumé :
The motor-generator set is widely used in the industry for converting large amounts of power energy to a different form of energy although the topic for this project motor-generator is smaller than usually utilized by an industrial company. The primary purpose of this small version motor-generator is for learning tool used by students associated with Electrical Power Engineering or Industrial Computer System Engineering at Murdoch University. The equipment is located in 1.003 Pilot Plant Engineering & Energy Building and was used in previous years by students at Murdoch University.
The fundamental aim of the project is to get the apparatus operating correctly and establish accurate communication and control. Investigate the effects of Variable Speed Drive on the motor, the effects of rotor speed and loads on the generator. To design and implement a working communication and control program in the system using LabVIEW software, it should display the following outputs; Field Voltage, Armature Voltage, Current, Power, Synchronous Speed of Motor, Rotor Speed, Force, and Torque.
It will be discussed in this report the fundamentals of motor-generator, National Instrument Data Acquisition card, and the LabVIEW software that being used and also the different components used as communication for the motor-generator. The major equipment of the system that will investigate are the following; Variable Speed Drive (VSD), Induction Motor, DC Generator, and the NI DAQ card. With understanding these pieces of equipment, it would determine accurate data information in the outputs. Allen Bradley variable speed drive powered and control the induction motor’s speed, while the National Instrument Data Acquisition card receives the systems information and addresses the controls. The four-kilowatt three-phase induction motor with 415 Voltage and 7.7 Amps which runs at 1455 revolution per minute. The DC generator converts mechanical energy into electrical energy and produces the measured DC voltage output with a variable load bank. The software control for this project is LabVIEW, which reads and writes to different components of the project through NI 6013, 50 pin DAQ card.
To ensure the implementation of the communication and control program, it was run with many trials that produced accurate results. The output results of Voltage, Current and Power are displayed in the waveform were expected, the Strain Gauge that measured force were also shown as well as the torque concerning the level arm of the generator. The rotor speed was calculated based on the synchronous speed and slip of the motor and not measured by a proximity sensor. The calculated values of rotor speed were compared to the tachometers measured value.
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Lindell, Jonas, et Filip Lagerholm. « WPS - WiFi Protected Setup : En studie om Wi-Fi Protected Setup som autentiseringsmetod ». Thesis, Högskolan i Halmstad, Akademin för informationsteknologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-40093.
Texte intégral
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Mertens, Frank. « Entwicklung eines Computerprogramms zur Durchführung elektronischer Setups ». [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=958332932.
Texte intégral
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Mertens, Frank. « Entwicklung eines Computerprogramms zur Durchführung elektronischer Setups ». Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/14456.
Texte intégralRésumé :
Es wird ein selbst entwickeltes Programm für Personalcomputer zur Simulation eines kieferorthopädischen Setups vorgestellt. Das Programm arbeitet mit einem Beispieldatensatz, der mikroskopisch gewonnen wurde. Mit dem Programm "VirtSet" lassen sich Zähne unabhängig voneinander positionieren, da sie sich auf eigene Koordinatensysteme beziehen. Die Ausrichtungen dieser Koordinatensysteme entsprechen den zahnärztlichen Richtungsbezeichnungen. Das Programm bietet eine halbautomatische Positionierung zu den mesialen und distalen Nachbarzähnen und zu den Antagonisten an. Das Programm erlaubt es, eine Zahnstellung mit mindestens vier antagonistischen Kontaktpunkten zu berechnen. Befinden sich beim Positionieren der Zähne Wurzelanteile außerhalb der Alveolarknochen, so wird dies dargestellt. Ferner wird ein Werkzeug zur exakten Positionierung der Zähne angeboten. Man kann die Zähne derart positionieren, daß sich Zahnanteile überlappen, und diese dann in einem speziellen Programmteil strippen. Zähne lassen sich extrahieren. Alle Änderungen an den Zähnen und deren Stellungen lassen sich rückgängig machen. Es wird ein halbindividueller Artikulator simuliert, mit dem man Protrusions-, Laterotrusions- und Okklusionsbewegungen realitätsnah darstellen kann. Mit virtuellem Kontaktpapier verschiedener Stärke lassen sich unterschiedliche Kontaktsituationen darstellen. Die Ausgabe erfolgt am Bildschirm in photorealistischer Darstellung. Es lassen sich diverse Einstellungen vornehmen, so daß man verschiedene Flächenarten wie zum Beispiel Zahnkronen-, Wurzel-, Kontaktpunkt- oder Artikulationsflächen differenzieren kann. Der Artikulator läßt sich von verschiedenen Seiten betrachten. Es lassen sich Bereiche unbegrenzt vergrößern und verkleinern. Die Darstellung auf dem Bildschirm läßt sich auf einem Drucker ausgeben, ebenso die Maße der durchgeführten Rotationen und Verschiebungen bezogen auf die zahn- und kieferspezifischen Achsen. Die Genauigkeit der Berechnungen liegt bei einem Mikrometer. Download des Computerprogramms für Windows95/98A computer program for simulating an orthodontic set up is presented. It seeks to offer a precise and practical contribution to computer-animated tools for orthodontics. The program is based on an exemplary set of data which was obtained microscopically. As a special feature, the teeth can be positioned independently as they refer to their own coordinate system. The alignments correspond to the dental nomenclature, for instance mesial, oral, apical. Moreover, antagonists and neighbouring teeth can be positioned semi-automatically. It is possible to calculate and present a minimum of four antagonistic contact points for each pair of teeth. If parts of the roots are outside the alveolar bone these are illustrated graphically. As another feature, the program offers a tool for an exact positioning of the teeth. Teeth can be positioned in an overlapping arrangement and subsequently can be stripped interdentally. The user can also extract teeth. Any changes of teeth and their positions can be reversed. Moreover the program allows to simulate a semi-individual articulator depicting protrusive, laterotrusive and occlusive movements authentically. The user can identify different contact points with the aid of virtual articulation foil. Besides, the program offers several application-oriented features: All computer-animated pictures have photographic qualities. That allows differentiations between various surface areas, such as crown, root, occlusal contact and articulation surfaces. The articulator can be looked at from different points of view. All areas can be zoomed in and out without limitations. Both the depictions and the measures of taken rotations related to the axes of individual teeth can be printed in full. The precision of all calculations is about one micrometer. Download the Computerprogram for MS-Windows95/98
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Dunn, Scott Lindsay. « Wave setup in river entrances / ». [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17132.pdf.
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Bergström, Patrik. « Automated Setup of Display Protocols ». Thesis, Linköpings universitet, Databas och informationsteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-117745.
Texte intégralRésumé :
Radiologists' workload has been steadily increasing for decades. As digital technology matures it improves the workflow for radiology departments and decreases the time necessary to examine patients. Computer systems are widely used in health care and are for example used to view radiology images. To simplify this, display protocols based on examination data are used to automatically create a layout and hang images for the user. To cover a wide variety of examinations hundreds of protocols must be created, which is a time-consuming task and the system can still fail to hang series if strict requirements on the protocols are not met. To remove the need for this manual step we propose to use machine learning based on past manually corrected presentations. The classifiers are trained on the metadata in the examination and how the radiologist preferred to hang the series. The chosen approach was to create classifiers for different layout rules and then use these predictions in an algorithm for assigning series types to individual image slots according to categories based on metadata, similar to how display protocol works. The resulting presentations shows that the system is able to learn, but must increase its prediction accuracy if it is to be used commercially. Analyses of the different parts show that increased accuracy in early steps should improve overall success.Röntgenläkares arbetsbörda har under flera årtionden ökat. Den digitala sjukvårdsteknologin utvecklas ständigt vilket bidrar till ett förbättrat arbetsflöde och kortare undersökningstider i radiologiavdelningar. Datorsystem används idag överallt inom sjukvården och används bland annat för att visa bilder åt röntgenläkare. För att underlätta visningen används display protocol som automatiskt skapar layouts och hänger bilder åt användaren. För att täcka ett stort antal olika undersökningstyper krävs att användaren skapar hundratals protokoll vilket är en tidskrävande uppgift, och systemet kan ändå misslyckas med att hänga upp bilder om de strikta kraven protokollen ställer inte uppfylls. För att ta bort detta manuella steg föreslår vi att man använder maskininlärning baserat på tidigare sparade presentationer. Klassificerarna tränas på undersökningens metadata och radiologens preferenser på hängning av serier. Den valda metoden går ut på att skapa klassificerare för olika layout-regler och att sedan använda deras output i en algoritm som placerar ut series-typer till individuella bildplatser enligt kategorier baserade på metadata. Denna metod liknar den process de nuvarande display protokollen utför. De presentationer som skapats visar att systemet kan läras upp, men kräver högre precision om det ska användas kommersiellt. Analys av de olika delarna tyder på att ökad precision tidigt i systemet skulle öka den totala precision.
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Bertilsson, Jimmy, et Joakim Andersson. « Ställtidsoptimering ». Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-23744.
Texte intégralRésumé :
Emhart Glass AB är världsledande företag inom glasflasktillverkning. Dekonstruerar automatiserade maskiner som formar glasflaskor. I Sverige finns dettvå fabriker, en i Örebro och en i Sundsvall. I Örebro tillverkar man främstreservdelar och nya delar till maskinerna medan man i Sundsvall monterar ihopmaskinerna. Det finns totalt 15 olika fabriker och kontor över världen medhuvudkontor i schweiziska Cham.Eftersom Emhart Glass Örebro har för långa ställtider på några av deras maskinerska det undersökas hur omställningsarbetet går till i dagsläget och huromställningsarbetet skiljer sig åt mellan operatörerna. Det ska även undersökasom det finns några möjligheter till förbättringar samt om det i dagsläget finnsnågot standardiserat sätt som operatören borde följa. Ett dokument som beskriverhur ställarbetet ska gå till kommer även att tas fram.Ett utmärkt verktyg för att förkorta ställtiderna i en produktion är SMEDMetoden.Filosofin bakom SMED är att man ska analysera och skilja på inre ochyttre ställ. Med inre och yttre ställ menas de som endast kan utföras då maskinenär avstängd resp. de som kan utföras när maskinen är i drift.För att standardisera omställningsarbetet så att samtliga operatörer jobbar påliknande sätt så krävs det att man tar fram en dokumentation över hur arbetet skagå till. Därför har checklistor tagits fram till operatören. "Checklista -Omställning.xls" är en checklista med syftet att man ska kunna bocka för vilkadelar i förberedelserna man gjort inför kommande ställ. Den har tagits fram för attman enkelt ska kunna hålla reda på vilka delar man gjort om man blivit tvungenatt jobba med maskinen emellan förberedelserna eller om man slutar sitt skift ochlämnar delar av arbetet till nästa operatör.Om samtliga av dessa förbättringar införs kan man förvänta sig enställtidsreducering på 20,5% vilket motsvarar ca 35min per ställ. Ignorerar maninkörningstiderna och endast kollar på riggningstider kan man se en förbättring på36,4 %.Emhart Glass Ltd is a world leader in glass bottle manufacturing. They designautomated machines that shape glass bottles. In Sweden there are two factories,one in Örebro and one in Sundsvall. In Örebro they manufacture primarily spareparts and new parts for the machines while they in Sundsvall assemble themachines. There are a total of 15 factories and offices around the world with theheadquarter located in Swiss Cham.Since Emhart Glass Örebro has long setup times on some of their machines. Thisis why we want to identify the current setup process and how the setup processdiffers between operators. We will also look at whether there are anyopportunities for improvement to be made and if they have a standardized way towork. A document that describes how to setup work should be done will also bedeveloped.An excellent tool to shorten the setup time in a production is the SMED method.The philosophy behind SMED is that you should analyze and separate the innerand outer activities. Inner and outer activities mean those activities which canonly be performed when the machine is turned off, respectively those activitiesthat can be performed when the machine is in operation.In order to standardize the adjustment process so that all operators are working ina similar way it's required that you make a documentation about how the workshould be done. Therefore, checklists been developed to the operator. "Checklista- Omställning.xls" is a checklist with the purpose to be able to check which partsof the preparations they have made before the next setup work. It has beendesigned to be easy to keep track of what parts you have done if you had to workwith the machine between the trial or if you quit your shift and leaving parts of thework to the next operator.If all of these improvements are implemented, we expect a set-up time reductionof 20.5% which corresponds to about 35min per set-up. By ignoring the runningtime and only check on the setup times, one can see an improvement of 36.4%.
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Swarén, Mikael. « Experimental test setups and simulations in skiing mechanics ». Licentiate thesis, KTH, Strukturmekanik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-144408.
Texte intégralRésumé :
Product testing and development are essential parts in sports and for the athletes in their quest to reach the podium. Manufacturers of sports equipment often use basic test methods which do not test the equipment in a sports specific way. Much of the equipment used by world-class athletes is chosen based only on subjective tests and the athletes’ feelings. One short term aim was therefore to develop test methods for objective tests of sports equipment that also tested the equipment in a sports specific way. Another aim was to integrate mechanics and simulations to enhance the understanding of the test results. The more long term aims are to contribute to increased theoretical knowledge regarding test methods for sports equipment and to contribute to the development of test methods to create new and better sports equipment. Experimental tests combined with simulations can give valuable information to improve the performance and safety of sports equipment. Three studies dealt with the issue of objective yet sport specific test methods for sports equipment. The main methodological advancement is the modification of established test methods together with conventional mechanics calculations. New test devices and methodologies are proposed for alpine ski helmets and cross-country ski poles. Suggestions are given for improved test setups as well as theoretical simulation are introduced for glide tests of skis. The results show how sport specific test methodologies together with theoretical calculations can improve the objectiveness and relevance when testing sports equipment. However, the collected and used data require high precision to obtain high accuracy in the simulations. High data accuracy can be an issue in field measurements but also due to manufacturers not disclosing key material data. Still, the used methods and calculations in this thesis produce relevant and reliable results which can be implemented to accurate evaluations of different sports equipment. Even though it has not been a first priority aim in this work, the results from the alpine helmet study have been used by helmet manufacturers to design new helmets with increased safety properties. This further show how an objective and sport specific test approach together with theoretical simulation can improve sports equipment and in the longer perspective, also the athletes’ performances.QC 20140423
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Anjum, Nadeem. « Trajectory based video analysis in multi-camera setups ». Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/629.
Texte intégralRésumé :
This thesis presents an automated framework for activity analysis in multi-camera setups. We start with the calibration of cameras particularly without overlapping views. An algorithm is presented that exploits trajectory observations in each view and works iteratively on camera pairs. First outliers are identified and removed from observations of each camera. Next, spatio-temporal information derived from the available trajectory is used to estimate unobserved trajectory segments in areas uncovered by the cameras. The unobserved trajectory estimates are used to estimate the relative position of each camera pair, whereas the exit-entrance direction of each object is used to estimate their relative orientation. The process continues and iteratively approximates the configuration of all cameras with respect to each other. Finally, we refi ne the initial configuration estimates with bundle adjustment, based on the observed and estimated trajectory segments. For cameras with overlapping views, state-of-the-art homography based approaches are used for calibration. Next we establish object correspondence across multiple views. Our algorithm consists of three steps, namely association, fusion and linkage. For association, local trajectory pairs corresponding to the same physical object are estimated using multiple spatio-temporal features on a common ground plane. To disambiguate spurious associations, we employ a hybrid approach that utilises the matching results on the image plane and ground plane. The trajectory segments after association are fused by adaptive averaging. Trajectory linkage then integrates segments and generates a single trajectory of an object across the entire observed area. Finally, for activities analysis clustering is applied on complete trajectories. Our clustering algorithm is based on four main steps, namely the extraction of a set of representative trajectory features, non-parametric clustering, cluster merging and information fusion for the identification of normal and rare object motion patterns. First we transform the trajectories into a set of feature spaces on which Meanshift identi es the modes and the corresponding clusters. Furthermore, a merging procedure is devised to re fine these results by combining similar adjacent clusters. The fi nal common patterns are estimated by fusing the clustering results across all feature spaces. Clusters corresponding to reoccurring trajectories are considered as normal, whereas sparse trajectories are associated to abnormal and rare events. The performance of the proposed framework is evaluated on standard data-sets and compared with state-of-the-art techniques. Experimental results show that the proposed framework outperforms state-of-the-art algorithms both in terms of accuracy and robustness.
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Lee, Wen-Hsuan Ph D. Massachusetts Institute of Technology. « Development of microreactor setups for microwave organic synthesis ». Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98157.
Texte intégralRésumé :
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2015.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 135-140).
The main contribution of this work is the understanding of microwave heating and the microreactor design challenges involved through both chemical experiments and computational models. The original goal of this research is to develop a microreactor system in order to carry the microwave organic synthesis in continuous flow format and to understand the basic phenomena of microwave heating through accurate kinetic studies. Several heating issues were observed with the first microreactor setup, including an uneven temperature distribution across the microwave irradiated area and a temperature limitation that depends on the position of the reactor. To find the root of these problems, the electromagnetic field and the heat transfer scheme of the microwave system were modeled with COMSOL. The simulations show that there are three main causes to the heating issues: (1) the electric field has an inherent resonance structure and thus has an uneven magnitude within the microwave cavity, (2) the electric field changes with not only the material, but also the sizes and positions of the objects in the microwave cavity, (3) the air gaps in the microwave waveguide creates a large natural convection heat loss. The simulations gave us a deeper understanding of the microwave heating phenomena and were used to find the optimum design of the microreactor. A second multiple-layered glass reactor was designed accordingly to overcome the heating limitation and minimized the temperature unevenness. However, the non-uniform heating rate cannot be eliminated since it is inherent in the resonance structure of microwaves. Both the experimental results and the simulations of the final reactor show that even though the reactor can reach the desired temperature, the temperature range across the reactor could be up to 20 *C. In addition, it was found that the flow rate of the reaction greatly affects the thermal equilibrium of the reaction volume. Accurate temperature control is therefore still a challenge for kinetic studies to be feasible with the current single-mode microwave system. The benefit of microwave heating is therefore still in the qualitative screening of chemical compounds, a feature which was demonstrated with a Fischer-Indole screening in the final setup.
by Wen-Hsuan Lee.
Ph. D.
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Januzi, Altin. « Triple-Camera Setups for Image-Based Depth Estimation ». Thesis, Uppsala universitet, Institutionen för elektroteknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422717.
Texte intégralRésumé :
This study was conducted as to attempt to find whether a three-camera setup could improve depth map retrieval as opposed to a two-camera setup. The study is based on three main ideas to exploit information from the additional camera. These are three cameras on one axis, as to exploit wide and short baseline benefits, three cameras on different axes, as to exploit vertical and horizontal scanning of the scene and a third idea of combining the two previous ideas. More than three cameras would impose particular implications on the solution and without sufficient theoretical justification thereof the study was limited to a study of the different three-camera configurations possible. As a practical connection was of interest, the study was further limited by the possibility to perform in real-time. An implementation based on previous research was made such as to evaluate images with specific scenes. Pre-processing by Census transformation of the images, camera calibration and rectification of different camera setups and optimizaton by the SGM algorithm are part of the solution used to retrieve results to analyse. Two tests were then studied, first one with rendered images and then one with images from real cameras. From these tests it was noted that a three-camera configuration can improve upon the results significantly and further, if the third camera was placed in perpendicular axis to the first camera pair, unique information was yielded which improves upon the result in specific cases. Using three cameras on the same axis showed no improvement when considering the error metrics BMP and BMPRE, but offers wider application uses, consistently providing better results than the worst pair.
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Manuylova, Ekaterina. « Investigations of stereo setup for Kinect ». Thesis, Linköpings universitet, Institutionen för teknik och naturvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-75855.
Texte intégralRésumé :
The main purpose of this work is to investigate the behavior of the recently released by Microsoft company the Kinect sensor, which contains the properties that go beyond ordinary cameras. Normally, in order to create a 3D reconstruction of the scene two cameras are required. Whereas, the Kinect device, due to the properties of the Infrared projector and sensor allows to create the same type of the reconstruction using only one device. However, the depth images, which are generated by the Infrared laser projector and monochrome sensor in Kinect can contain undefined values. Therefore, in addition to other investigations this project contains an idea how to improve the quality of the depth images. However, the base aim of this work is to perform a reconstruction of the scene based on the color images using pair of Kinects which will be compared with the results generated by using depth information from one Kinect. In addition, the report contains the information how to check that all the performed calculations were done correctly. All the algorithms which were used in the project as well as the achieved results will be described and discussed in the separate chapters in the current report.
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Lundberg, Olof, et Jacob Wesslén. « Development of Setup for Biotac Sensor ». Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51842.
Texte intégralRésumé :
This is a thesis project done on behalf of BillerudKornäs in collaboration with Örebro University in a research project investigating grip stiffness of carton board packages. This is of interest because a better understanding of it would allow optimizing of the packaging design and result in a better product. In this thesis the mission has been to develop a setup for a sensor enabling a method of testing on packages. This has been carried out as a product development project. After a preparation study a specification of requirements was written. With the use of this a number of concepts were generated. Through evaluation one concept was chosen for further development and built as a prototype model. The prototype did not work satisfactory at the end of the project but could with some improvements be useful in testing packages with the intended sensor.Detta är ett examensarbete utfört åt BillerudKorsnäs i samarbete med Örebro universitet inom ett forskningsprojekt där greppstyvhet hos kartongförpackningar undersöks. Det här är intressant eftersom att en djupare förståelse inom området skulle möjliggöra optimering av förpackningsdesignen och resultera i en bättre produkt. Uppgiften i detta examensarbete har varit att utveckla en testrigg för en sensor med syfte att möjliggöra en laborativ metod för att testa förpackningar. Detta har bedrivits som ett produktutvecklingsprojekt. Efter att en förstudie gjorts togs en kravspecifikation fram. Med hjälp utav vad som definierats i denna generades ett antal koncept. Genom utvärdering valdes ett koncept för vidareutveckling och byggdes sedan som prototypmodell. Prototypen fungerade inte tillfredställande vid projektets slut men skulle efter vissa förbättringar kunna vara användbar vid tester av förpackningar med den avsedda sensorn.
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Andzik, Rob, et Charles (Chuck) N. Brans. « AUTOMATIC RANGE EQUIPMENT SETUP AND CONTROL ». International Foundation for Telemetering, 2006. http://hdl.handle.net/10150/604137.
Texte intégralRésumé :
ITC/USA 2006 Conference Proceedings / The Forty-Second Annual International Telemetering Conference and Technical Exhibition / October 23-26, 2006 / Town and Country Resort & Convention Center, San Diego, CaliforniaToday Ranges are faced with the typical dilemma of doing more with less—less money, less time, and less experienced range personnel. Meanwhile, Ranges are being forced to make their operations more efficient in use of time, money, and functionality. As a result, Ranges are looking for automated ways to remotely configure and operate their tracking stations and to provide interoperability between ranges, sites, and equipment. RT Logic worked with numerous range operators and equipment vendors to create an open software architecture that provides rapid device configuration, equipment status at a glance, and automatic fault detection and isolation. RT Logic’s architecture utilizes the CORBA specification to achieve extensibility and scalability for future range requirements. Adoption of this architecture and approach will reduce costs, time, and mistakes.
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Thom, Gary A. « PCM SIMULATOR ARCHITECTURE REDUCES SETUP COMPLEXITY ». International Foundation for Telemetering, 1985. http://hdl.handle.net/10150/615740.
Texte intégralRésumé :
International Telemetering Conference Proceedings / October 28-31, 1985 / Riviera Hotel, Las Vegas, NevadaThe advent of Bit Slice Processors and related architectures has produced numerous high performance PCM Data Simulators. Many of these fall into the category of stored program simulators, which give the user unlimited flexibility and power. These simulators allow the user to program almost any imaginable format, with combinations of subframes, subsubframes, and asynchronously embedded subframes. The drawback is that the user is forced to program the simulator using a very detailed machine level language which usually has no obvious relation to PCM frame formats. A new simulator architecture allows the user to describe the frame format to be simulated in familiar terms. This eliminates the need to learn yet another programming language or develop a Compiler. The user identifies common parameters such as frame length, subframe length, and where special words should be located. These special words can be unique sensor data words, a table of sensor data, ID counters, subframe slots and so on.
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DI, NEZZA Francesca. « Setup of nanodevices and their applications ». Doctoral thesis, Università degli studi del Molise, 2017. http://hdl.handle.net/11695/79697.
Texte intégralRésumé :
In questi ultimi anni le nanoscienze hanno profondamente modificato la medicina, sia in campo diagnostico sia terapeutico. E’ nata così la nanomedicina come disciplina in grado di creare terapie personalizzate. Questo nuovo paradigma della medicina si bassa sulla consapevolezza di creare dei dispositivi di dimensioni nanometriche contenenti specifici principi attivi capaci di interagire con particolari tessuti e quindi di curare particolari patologie. Tale disciplina fornisce un valido aiuto anche in campo diagnostico con la creazione di specifici sistemi fluorescenti, per esempio. Il contributo più efficace della nanomedicina è da ricercare nella teranostica (terapeutica più diagnostica) dove si costruiscono nanodevice in grado di veicolare contemporaneamente farmaci ad uso terapeutico e nanoparticelle ad uso diagnostico.
L’attività di questo dottorato si è indirizzata verso la creazione di nano sistemi che avessero una immediata applicazione alla medicina. A tal prosposito si sono messi a punto solo liposomi per la veicolazioni di principi attivi idrosolubili. In particolare sono stati messi a punto particolari colliri liposomiali per la terapia dell’ipertensione intraoculare e soluzioni liposomiali di coloranti vitali da usare nelle operazioni di canalostomia e canaloplastica soluzioni liposomiali capaci di attivare il canale del Ca2+ nel caso di particolari patologie cerebrali. Inoltre sono state derivatizzate nanoparticelle colloidali di oro per la veicolazione di principi attivi attravesro la somministrazione orale.In recent years nanoscience have profoundly changed the medicine, both in the diagnostic field and therapeutic. It 'gave rise to nanomedicine as a discipline capable of creating personalized therapies. This new paradigm of medicine is low on the awareness of creating nanometer sized devices containing specific active principles capable of interacting with particular tissues and thus to treat particular pathologies. This discipline also provides a valuable aid in the diagnostic field with the creation of specific fluorescent systems, for example. The most effective contribution of nanomedicine is to be found in theranostics (more therapeutic diagnostics) where they build nanodevices capable of transmitting simultaneously for therapeutic use medication and diagnostic use nanoparticles. The activity of this PhD has been directed toward the creation of nano systems that have an immediate application to medicine. To achieve this goal they have developed only liposomes for water-soluble therapeutic agents. In particular they were developed special liposomal eye drops for the therapy of intraocular hypertension and liposomal solutions of vital dyes to be used in operations of canalostomia and canaloplasty liposomal solutions capable of activating the Ca2 + channel in the case of particular brain pathologies. In addition, we have been derivatized gold nanoparticles for the delivery of active ingredients through oral administration.
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Ota, Iara Naomi Nobre. « Quantum information and relativity : harvesting entanglement in different setups ». Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/76/76131/tde-02102018-093613/.
Texte intégralRésumé :
The aim of this work is present the phenomenon denoted entanglement harvesting. We begin by introducing entanglement historically. Following, we go beyond the one particle theory in flat spacetime and introduce Quantum Field Theory in Curved Spacetime, showing two famous consequences: the Unruh effect and the Hawking radiation. Finally, we analyze entanglement harvesting for two Unruh-deWitt detectors. In the fisrt example, we see that there is a \"sudden death\" point of entanglement harvesting when the detectors are near the BTZ black hole event horizon, due to redshift effect and Hawking radiation. Then, we compare the phenomenon for different scenarios, and find out that it is sensitive to the structure of spacetime. Finally, we see how detectors\' parameters affect it and find out that the smoothness of the switching of the detectors\' coupling to the field is extremely relevant. We also see how the parameters can be used to optimize entanglement harvested.O objetivo desse trabalho é apresentar o fenômeno denotado colheita de emaranhamento. Primeiramente fazemos uma introdução histórica de emaranhamento de estados quânticos. Em seguida, introduzimos a Teoria Quântica de Campos no Espaço-tempo Curvo, como um passo além da teoria quântica de uma partícula no espaço-tempo plano, e demonstramos dois resultados famosos da teoria: o efeito Unruh e a radiação Hawking. Por fim, fazemos uma analise do fenômeno de colheita de emaranhamento para dois detectores Unruh-deWitt. Nosso primeiro exemplo mostra que há um ponto de \"morte súbita\" do fenômeno quando os detectores se aproximam do horizonte de eventos de um buraco negro de BTZ, que é uma consequência do efeito de redshift e da radiação Hawking. Em seguida, comparamos o fenômeno em cenários diferentes, e observamos que a colheita de emaranhamento é sensível à estrutura do espaço-tempo. Por último, analisamos como os parâmetros dos detectores afetam a colheita de emaranhamento, e vemos que a suavidade em que o acoplamento dos detectores com o campo é \"ligado\" e \"desligado\" é extremamente relevante. Também analisamos como podemos usar os parâmetros dos detectores para otimizar a quantidade de emaranhamento colhida.
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Lakehal, Massil. « Out of Equilibrium Lattice Dynamics in Pump Probe Setups ». Thesis, Université de Paris (2019-....), 2020. http://www.theses.fr/2020UNIP7039.
Texte intégralRésumé :
L'étude de la dynamique hors équilibre des systèmes fortement corrélés, à l'aide de laser femtoseconde, a révélé une variété de phénomènes sans analogue en physique d'équilibre. Dans cette thèse, nous étudions théoriquement la dynamique hors équilibre des degrés de liberté du réseau et leur signature en spectroscopie pompe-sonde. Nous développons une description microscopique des phonons cohérents displacive excité par le laser. La théorie capture la rétroaction de l'excitation des phonons sur le fluide électronique, qui manque dans la formulation phénoménologique actuelle. Nous montrons que cette rétroaction conduit à une oscillation avec une fréquence qui dépend du temps aux temps courts, même si le mouvement des phonons est harmonique. Pour les temps longs, cette rétroaction apparaît comme une phase résiduelle dans le signal oscillatoire. Nous appliquons la théorie au BaFe2As2, nous expliquons l'origine de la phase du signal oscillatoire rapporté dans des expériences récentes, et nous prédisons que le système oscille avec une fréquence décalé vers le rouge pour les grandes fluences. Notre théorie ouvre également la possibilité d'extraire des informations d'équilibre à partir la dynamique des phonons cohérents. Un autre phénomène intéressant qui a été observé en spectroscopie pompe-sonde est l'oscillation des fluctuations du réseau au double de la fréquence d’un phonon du système étudié. Ces oscillations sont interprétées comme une signature d'états de phonons squeezé macroscopique. Dans ce travail, nous identifions d'autres mécanismes d'oscillations à une fréquence double autre que le squeezing. Nous montrons qu'un quench de la température du bain thermique induite par la pompe, à laquelle le phonon est couplé, ou l'excitation d'un phonon cohérent pour lequel l'anharmonicité cubique est permise par symétrie peut également produire de telles oscillations en spectroscopie sans que le phonon soit dans un état squeezé. Nous concluons que, contrairement à ce qui est communément admis, les oscillations à double fréquence phononique en spectroscopie de bruit ne sont pas nécessairement une signature des phonons squeezés. Nous soulignons ce qui peut être un critère fiable pour identifier un phonon squeezé en utilisant la spectroscopie pompe-sondeThe study of the out of equilibrium dynamics of strongly correlated systems, using ultrafast pulses, uncovered a plethora of phenomena with no analog in equilibrium physics. In this thesis, we theoretically investigate the out of equilibrium dynamics of the lattice degrees of freedom and their signature in pump-probe spectroscopy. We develop a Hamiltonian-based microscopic description of laser pump induced displacive coherent phonons. The theory captures the feedback of the phonon excitation upon the electronic fluid, which is missing in the state-of-the-art phenomenological formulation. We show that this feedback leads to chirping at short timescales, even if the phonon motion is harmonic. At long times, this feedback appears as a finite phase in the oscillatory signal. We apply the theory to BaFe2As2, explain the origin of the phase in the oscillatory signal reported in recent experiments, and we predict that the system will exhibit redshifted chirping at larger fluence. Our theory also opens the possibility to extract equilibrium information from coherent phonon dynamics. Another interesting phenomenon that have been reported in pump-probe spectroscopy is the oscillation of the lattice fluctuations at double phonon frequency. These oscillations are invariably interpreted as a signature of macroscopic squeezed phonon states. In this work, we identify other mechanisms of double phonon frequency oscillations that do not involve squeezing. We show that a pump induced temperature quench of the bath, to which the phonon is coupled to, or exciting a coherent phonon for which cubic anharmonicity is allowed by symmetry can also produce such oscillations in noise spectroscopy without squeezing the phonon state. We conclude that, in contrast with what is commonly believed, double phonon frequency oscillations in noise spectroscopy are not necessarily a signature of macroscopic phonon squeezing. We point out what can be a reliable criterion to identify a squeezed phonon using pump-probe spectroscopy
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Andersson, Lucas, et Alexander Sjöblom. « An analysis of construction logistics setups for Berga Äng ». Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-177544.
Texte intégralRésumé :
Byggindustrin är en komplex bransch där varje byggprojekt är unikt, vilket medför svårigheter i att finna logistiklösningar som är anpassade till byggarbetsplatsen. Beroende på omgivning och plats där bygget skall utföras, storlek på bygget, vilka material som ska användas under byggets olika skeden för konstruktion och hur flödet påverkas av transporter till byggarbetsplatsen. Examensarbetet är utfört i samarbete med Aurum Fastighetsutveckling och forskningsprojektet Fossilfri Bygglogistik, finansierat av Triple F. Aurum Fastighetsutveckling är intresserade av att se hur ett tänkbart transportflöde för byggarbetsplatsen Berg Äng som är planerad mellan 20242028 kan se ut under olika faser för byggnadsprojektet. Syftet med denna studie är därför att genomföra en simulering för ett undersöka transportflödet och effekterna för olika logistiklösningar under byggnadsprocessen. Syftet har utformats baserat på tre frågeställningar, vilka har besvarats med hjälp av kvantitativa och kvalitativa metoder. De kvalitativa metoderna består främst av intervjuer och observationer vid insamling av data och för att generera ett resultat har kvantitativ metod i form av simulering använts. Data för beräknandet av antalet förväntade transporter och när dessa ankommer har givits av forskningsprojektet Störningsfri stad vid Linköpings universitet. Totalt har tre kvartal för byggprojektet Berga Äng simulerats. Efter analys av simuleringsresultaten konstaterades att det kommer uppstå logistikutmaningar som måste tas i åtanke vid planeringsfasen. Kvartal Q2 2026 har två potentiella zoner med lägenhetshus på byggarbetsplatsen som eventuellt inte kommer hinna klart inom den utsatta projekttiden. Detta på grund av det höga antalet transporter som förväntas ankomma till zonerna under den planerade tiden för byggnation på dessa. Analysen visar även att eventuella köer och väntetid för lastbilar under byggprocessen kan reduceras vid användning av logistiklösningar, så som en terminal eller check-point. Slutsatsen av denna studie belyser vikten av att ha antalet transporter som förväntas ankomma till byggarbetsplatsen i beaktning under planeringsfasen. För att bidra till en skarpare planering med bättre precision bör mer data för transporthantering samlas in inom byggbranschen, vilket kan bidra till att förutse eventuella perioder under byggnationen där schemaläggning och planering av transporter är extra viktigt. Genom att förutse detta kan även slutsatser kring hur vida användandet av logistiklösningar är nödvändigt eller inte under byggnationen genomföras, och beslut kan tas kring när dessa bör användas.Examensarbetet är utfört vid Institutionen för teknik och naturvetenskap (ITN) vid Tekniska fakulteten, Linköpings universitet
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Silva, Augusto Almeida da. « Heurística evolutiva para problemas de programação em no-wait flowshop com tempos de setup ». Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/18/18156/tde-15012013-101434/.
Texte intégralRésumé :
Este trabalho aborda o problema de no-wait flowshop em um ambiente com custos de setup apartados dos tempos de processamento, são investigados os casos de setups dependentes e independentes da seqüência para makespan e total flowtime. Diversas aplicações práticas podem ser modeladas sob estas suposições, dentre elas destacamos a indústria química e alimentícia. É proposta uma metaheurística evolutiva baseada em algoritmo genético e clustering search e seus resultados são comparados com os métodos de Brown et al (2004), França et al (2006) e Ruiz e Allahverdi (2007) através dos bancos de dados de Ruiz e Stützle (2008) e Ruiz e Allahverdi (2007). Os métodos são avaliados segundo o percentual de sucesso e desvio relativo médio. Os resultados obtidos demonstram a superioridade do método proposto para problemas de grande porte.This work intends to research the no-wait flowshop scheduling problem with setup times separated from the processing costs; the both cases where the sequence is dependent and independent are targeted for makespan and total flowtime. There are numerous practical situations that can be modeled under these assumptions, such as, chemical industry, food processing, etc. A hybrid metaheuristic method based on a genetic algorithm and clustering search is proposed and its results are compared to the methods of Brown et al (2004), França et al (2006) e Ruiz e Allahverdi (2007) using the data base from Ruiz e Stützle (2008) and Ruiz e Allahverdi (2007). The methods are evaluated as regarding the success rate and average relative deviation. The results show that the proposed method delivers better solutions for problems with higher complexity.
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Kallumadanda, Ganesh Chetan C. « Value stream mapping in a welding setup ». Menomonie, WI : University of Wisconsin--Stout, 2005. http://www.uwstout.edu/lib/thesis/2005/2005kallumadandag.pdf.
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Yakadina, Irina. « Limiting Debt in the Optional Taxation Setup ». Doctoral thesis, Universitat Pompeu Fabra, 2002. http://hdl.handle.net/10803/7424.
Texte intégralRésumé :
La literatura reciente que se ha concentrado en la imposición fiscal óptima de los factores de producción (el capital y el trabajo) llega a las conclusiones siguientes. Para un gobierno benevolente que maximiza el bienestar de los consumidores del país, es óptimo no recurrir a un impuesto sobre el capital a largo plazo. El resultado se debe a Chamley y Judd.Esta tesis estudia los efectos sobre los impuestos óptimos al capital y al trabajo cuando se limita la deuda del gobierno. La tesis está compuesta de tres capítulos relacionados, el primero de los cuales sirve de introducción y hace un resumen de la extensa literatura sobre la imposición fiscal. El segundo se dedica a estudiar qué impacto puede tener la introducción de unos límites superiores exógenos sobre la nueva deuda del gobierno y la del consumidor representativo sobre la política fiscal óptima. El modelo del equilibrio general en un entorno estocástico considerado en este capítulo no tiene solución analítica debido a su conocida complejidad. Además, los límites a la deuda alteran el supuesto habitual de mercados completos añadiendo dificultades a la búsqueda de una solución numérica. Los resultados principales de este capítulo son: límites a la absorción de choques externos por medio de la deuda implican el uso del impuesto sobre el capital. El modelo con límites a la deuda comparado al modelo con mercados completos tiene implicaciones mas plausibles para el comportamiento de los dos impuestos. En particular, los impuestos sobre el trabajo reproducen perfectamente las características principales de los mismos impuestos en los datos para los países del G7.
El tercer capítulo extiende el modelo anterior para examinar los límites a la deuda del consumidor al introducir el requisito de colateral en el espíritu de Kiyotaki y Moore. El resultado del impuesto óptimo positivo sobre capital positivo es aún mas fuerte porque el entorno de la economía en este modelo es determinístico. Hasta ahora son pocos los ejemplos de modelos determinísticos en la literatura para los cuales el resultado de Chamley y Judd no se cumple.
Incorporar el límite endógeno sobre la deuda del consumidor en el modelo estocástico del capítulo dos sería un campo de investigación muy prometedor. Permitiría mejorar las predicciones del comportamiento de impuestos sobre capital y hacerlos muy semejantes a los datos reales, como es ya el caso para los impuestos sobre el trabajo en el modelo del segundo capítulo de mi tesis.
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Kramer, Steven Boyd. « Evaluation of setup economies in cellular manufacturing ». College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1781.
Texte intégralRésumé :
Thesis (Ph. D.) -- University of Maryland, College Park, 2004.Thesis research directed by: Business and Management. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Sha, Mao Xuan, Xi Tao Wang et Shu Zuo. « WSN Setup by means of Software Agents ». Thesis, Högskolan i Halmstad, Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16450.
Texte intégralRésumé :
A significant challenge in the Wireless Sensor Networks (WSN) research field is to find flexible and energy efficient strategies to perform the network setup and configuration to accomplish specified sensing missions. This thesis presents an approach which uses mobile agents to disseminate and allocate sensing missions to the sensor nodes. The addressed problem refers to the selection of appropriate nodes to perform the sensing mission, by using a decentralized approach supported by mobile software agents. Traditional approaches to deal with WSN setup use the pre-planned strategies, which are deliberately modelled, designed and tuned before the network deployment, and thus are not flexible. This thesis presents an alternative approach based on Belief Desire Intention-model agents using JASON, instead of traditional approaches. Simulation results provides evidences that this approach can achieve the goals of a sensing mission setup by decisions autonomously taken by the sensor node, diminishing then the need for communication among the sensor nodes, hence saving energy resources.
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Gilbert, Sebastien. « Camera pose estimation from a stereo setup ». Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/27138.
Texte intégralRésumé :
This thesis addresses the problem of estimation of the camera poses with respect to a rigid object, which is equivalent to the problem of tridimensional registration of a moving rigid object before fixed cameras. Matching, tracking and 3D reconstruction of feature points by a stereoscopic vision setup allows the computation of the homogeneous transformation matrix linking two consecutive scene captures. Robustness to errors is provided by the scene rigidity constraint. Accumulation of error is compensated through loop detection in the calculated camera poses. Experimental results show the validity of the obtained camera poses.
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Mäcker, Alexander [Verfasser]. « On scheduling with setup times / Alexander Mäcker ». Paderborn : Universitätsbibliothek, 2019. http://d-nb.info/1200017560/34.
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Lien, Fredrik. « Modelling and Test Setup for Sandwich Radomes ». Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for elektronikk og telekommunikasjon, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-26233.
Texte intégralRésumé :
Sandwich radomes are structures providing communication- and radar antennas with protection from the environment. The sandwich materials are designed to affect the electromagnetic radiation as little as possible with respect to transmission- and reflection loss, boresight error, boresight error slope, increased sidelobe levels and depolarization. In order to match the frequency response of the radome material to the specifications, simulation and optimization of the thickness and dielectric properties of the individual sandwich layers is done.To simulate the transmission- and reflection coefficients for sandwich materials a Matlab scripts has been developed. The script calculate the response for up to 10 different layers for incidence angles and frequencies defined by the user. Verification of the results has been done by comparing the simulated data to results in Kozakoff (2010) and show that the script works correctly.Waveguide measurement and calibration components have been designed and manufacturedin order to measure samples of dielectric materials and samples of complete radome sandwich materials. The results have been compared to results from simulations done in CST Microwave Studio and show a good match for complete sandwich materials and thicker dielectrics. However the measurement results for thin material samples show more deviation compared to the simulation results. The deviation seems to be dependent on the thickness of the sample.Two optimization routines have been developed in Matlab. The first compare the measuredresults from measurements to the simulated results from Matlab. Least square optimization is used to adjust the dielectric properties (relative permittivity and dielectric loss tangent) used by the simulation script in order to match the simulation values to the measured values. The results show good match of the optimized relative permittivity for a 22 mm thick sample of Teflon with the optimized value deviating 1.3% from the specified permittivity value. With decreasing thickness of the test samples the deviation increased to approximately 3-12%. The optimized loss tangent values however show very large deviation from the specified values and should be treated as invalid. The main reasons are believed to be the low loss of the materials combined with the thickness relative to the measurement wavelength.The second optimization routine adjust the thickness of the individual layers to achieveminimum loss for one- or more predefined frequency bands. The results show that theoptimization work as intended. To investigate the effect of production errors/productiontolerances the core thickness of an A-sandwich has been adjusted with +/-10% from theoptimized thickness. The result show that the thickness deviation has a bigger impact onhigh frequencies.
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Filho, Márcio Antonio Ferreira Belo. « Lot sizing with setup carryover and crossover ». Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-29042016-142624/.
Texte intégralRésumé :
Production planning problems are of paramount importance within supply chain planning, supporting decisions on the transformation of raw materials into finished products. Lot sizing in production planning refers to the tactical/operational decisions related to the size and timing of production orders to satisfy a demand. The objectives of lot-sizing problems are generally economical-related, such as saving costs or increasing profits, though other aspects may be taken into account such as quality of the customer service and reduction of inventory levels. Lot-sizing problems are very common in production activities and an efficient planning of such activities gives the company a clear advantage over concurrent organizations. To that end it is required the consideration of realistic features of the industrial environment and product characteristics. By means of mathematical modelling, such considerations are crucial, though their inclusion results in more complex formulations. Although lot-sizing problems are well-known and largely studied, there is a lack of research in some real-world aspects. This thesis addresses two main characteristics at the lot-sizing context: (a) setup crossover; and (b) perishable products. The former allows the setup state of production line to be carried over between consecutive periods, even if the line is not yet ready for processing production orders. The latter characteristic considers that some products have fixed shelf-life and may spoil within the planning horizon, which clearly affects the production planning. Furthermore, two types of perishable products are considered, according to the duration of their lifetime: medium-term and short-term shelf-lives. The latter case is tighter than the former, implying more constrained production plans, even requiring an integration with other supply chain processes such as distribution planning. Research on stronger mathematical formulations and solution approaches for lot-sizing problems provides valuable tools for production planners. This thesis focuses on the development of mixed-integer linear programming (MILP) formulations for the lot-sizing problems considering the aforementioned features. Novel modelling techniques are introduced, such as the proposal of a disaggregated setup variable and the consideration of lot-sizing instead of batching decisions in the joint production and distribution planning problem. These formulations are subjected to computational experiments in state-of-the-art MILP-solvers. However, the inherent complexity of these problems may require problemdriven solution approaches. In this thesis, heuristic, metaheuristic and matheuristic (hybrid exact and heuristic) procedures are proposed. A lagrangean heuristic addresses the capacitated lot-sizing problem with setup carryover and perishable products. A novel dynamic programming procedure is used to achieve the optimal solution of the uncapacitated single-item lot-sizing problem with setup carryover and perishable item. A heuristic, a fix-and-optimize procedure and an adaptive large neighbourhood search approach are proposed for the operational integrated production and distribution planning. Computational results on generated set of instances based on the literature show that the proposed methods yields competitive performances against other literature approaches.Problemas de planejamento da produção são de suma importância no planejamento da cadeia de suprimentos, dando suporte às decisões da transformação de matérias-primas em produtos acabados. O dimensionamento de lotes em planejamento de produção é definido pelas decisões tático-operacionais relacionadas com o tamanho das ordens de produção e quando fabricá-las para satisfazer a demanda. Os objetivos destes problemas são geralmente de cunho econômico, tais como a redução de custos ou o aumento de lucros, embora outros aspectos possam ser considerados, tais como a qualidade do serviço ao cliente e a redução dos níveis de estoque. Problemas de dimensionamento de lotes são muito comuns em atividades de produção e um planejamento eficaz de tais atividades, estabelece uma clara vantagem à empresa em relação à concorrência. Para este objetivo, é necessária a consideração de características realistas do ambiente industrial e do produto. Para a modelagem matemática do problema, estas considerações são cruciais, embora sua inclusão resulte em formulações mais complexas. Embora os problemas de dimensionamento de lotes sejam bem conhecidos e amplamente estudados, várias características reais importantes não foram estudadas. Esta tese aborda, no contexto de dimensionamento de lotes, duas características muito relevantes: (a) preservação da preparação total e parcial; e (b) produtos perecíveis. A primeira permite que o estado de preparação de uma linha de produção seja mantido entre dois períodos consecutivos, mesmo que a linha de produção ainda não esteja totalmente pronta para o processamento de ordens de produção. A ultima característica determina que alguns produtos tem prazo de validade fixo, menor ou igual do que o horizonte de planejamento, o que afeta o planejamento da produção. Além disso, de acordo com a duração de sua vida útil, foram considerados dois tipos de produtos perecíveis: produtos com tempo de vida de médio e curto prazo. O ultimo caso resulta em um problema mais apertado do que o anterior, o que implica em planos de produção mais restritos. Isto pode exigir uma integração com outros processos da cadeia de suprimentos, tais como o planejamento de distribuição dos produtos acabados. Pesquisas sobre formulações matemáticas mais fortes e abordagens de solução para problemas de dimensionamento de lotes fornecem ferramentas valiosas para os planejadores de produção. O foco da tese reside no desenvolvimento de formulações de programação linear inteiro-mistas (MILP) para os problemas de dimensionamento de lotes, considerando as características mencionadas anteriormente. Novas técnicas de modelagem foram introduzidas, como a proposta de variáveis de preparação desagregadas e a consideração de decisões de dimensionamento de lotes ao invés de decisões de agrupamento de ordens de produção no problema integrado de planejamento de produção e distribuição. Estas formulações foram submetidas a experimentos computacionais em MILP-solvers de ponta. No entanto, a complexidade inerente destes problemas pode exigir abordagens de solução orientadas ao problema. Nesta tese, abordagens heurísticas, metaheurísticas e matheurísticas (híbrido de métodos exatos e heurísticos) foram propostas para os problemas discutidos. Uma heurística lagrangeana aborda o problema de dimensionamento de lotes com restrições de capacidade, preservação da preparação total e produtos perecíveis. Um novo procedimento de programação dinâmica e utilizado para encontrar a solução ótima do problema de dimensionamento de lotes de um único produto perecível, sem restrições de capacidade e preservação da preparação total. Uma heurística, um procedimento x-and-optimize e uma abordagem por buscas adaptativas em grande vizinhanças são propostas para o problema integrado de planejamento de produção e distribuição. Resultados computacionais em conjuntos de instâncias geradas com base na literatura mostram que os métodos propostos obtiveram performances competitivas com relação a outras abordagens da literatura.
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Clancy, Devin. « Static Tire Characterization for Race Vehicle Setup ». Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/76891.
Texte intégralRésumé :
In order to provide data for non-rolling tire models that are used in computer simulations of vehicle dynamics, a tire test rig is designed and manufactured which attaches to an MTS kinematics and compliance machine. This test rig is developed for the purpose of characterizing the loaded radius, overturning moment, and displacement of multiple tires in the vertical, lateral, and longitudinal test axes. Equations are developed and used to fit these parameters for the purpose of representing them in non-rolling vehicle simulation models.Master of Science
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Marklund, Daniel. « Control of a high temperature DLTS setup ». Thesis, Uppsala universitet, Institutionen för teknikvetenskaper, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328710.
Texte intégralRésumé :
This thesis deals with a DLTS-setup and how this can be controlled. The controlling program is constructed in LABVIEW, where a previous built program measuring transients at varying pulses been handled and tried to be implemented for this setup. Parts of the program was implemented successfully, other part needs more work. The heater in the setup has further been connected directly to the sample. This one has been tested to see that the setup can handle the heat and that the difference between the temperature at the sample and the setup did not differ too much. The result showed that the difference was not so big. Finally, DLTS tests was performed at samples of silicon carbide as well as on diamond, where transients could be measured up to 723 °C on the silicon carbide sample, while the tests of diamond only gave noise.
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Buschkühl, Lisbeth. « Multi-level capacitated lotsizing with setup carryover / ». Köln : Kölner Wiss.-Verl, 2008. http://d-nb.info/989792714/04.
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Tadi, Bhaskar Vijay Kumar Reddy. « Ultrasound hardware setup for CMP pad characterization ». [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000340.
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Lundberg, Tommy, et Daniel Nee. « Automatic Measurement Setup for new Optical FPGA:s ». Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-254228.
Texte intégralRésumé :
Aiming to reduce research and development times in the field of silicon photonics, this paper presents a method for automatized device testing. Focus lies on automatic optical coupling between the grating couplers on a chip and optical fibers and efficient switching between devices when performing laboratory tests on silicon photonic chips. A lab setup with high precision motorized stages has been built and an algorithm for finding the best optical coupling between fiber and chip, based on the light distribution properties of the fiber, has been implemented. The project results shows that, while these methods have the potential of considerable time savings, further testing is needed.
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Senniappan, Karthikeyan Yildirim Mehmet Bayram. « Parallel-machine scheduling with load-balancing and sequence-dependent setups ». Diss., A link to full text of this thesis in SOAR, 2006. http://soar.wichita.edu/dspace/handle/10057/679.
Texte intégralRésumé :
Thesis (M.S.)--Wichita State University, College of Engineering, Dept. of Industrial and Manufacturing Engineering."December 2006." Title from PDF title page (viewed on Sept. 18, 2007). Thesis adviser: Mehmet Bayram Yildirim. Includes bibliographic references (leaves 53-57).
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Naredi-Rainer, Nikolaus [Verfasser]. « Advanced Confocal Microscopy : From Setups To Applications / Nikolaus Naredi-Rainer ». München : Verlag Dr. Hut, 2014. http://d-nb.info/1050331907/34.
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Tubilla, Kuri Fernando. « Dynamic scheduling of manufacturing systems with setups and random disruptions ». Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67606.
Texte intégralRésumé :
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2011.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 249-256).
Manufacturing systems are often composed of machines that can produce a variety of items but that most undergo time-consuming (and possibly costly) setups when switching between product types. Scheduling these setups efficiently can have important economic effects on the performance of the plant and involves a tradeoff between throughput, inventory, and operating costs. In addition, the schedule must be robust to random disruptions such as failures or raw material shortages, which are common in production environments. In this thesis, we study policies that address the setup scheduling problem dynamically, in response to current conditions in the system. A new heuristic, called the Hedging Zone Policy (HZP), is introduced and developed. It is a dynamic-sequence policy that always produces the current part type at its maximum production rate until a fixed base stock level is reached. Then, before switching setups, the policy might produce the current part type at its demand rate for some additional time. When selecting changeovers, the HZP implements two types of decision rules. If the difference between base stock and surplus level is small for all part types, the item with the largest weighted difference is selected. Otherwise, the policy uses a fixed priority ranking to select between items that are far from their base stock value. In order to demonstrate the benefits of our policy, we also adapt and implement several other heuristics that have been proposed in the literature for related models. The policies are first analyzed in a purely deterministic setting. The stability of the HZP is addressed and it is shown that a poor selection of its parameters leads to a condition in which some low-priority parts are ignored, resulting in an unstable system. Using Lyapunov's direct method, we obtain an easy-to-evaluate and not-too-conservative condition that ensures production of all part types with bounded surplus. We then compare, through a series of extensive numerical experiments with three-part-type systems, the deterministic performance of the policies in both make-to-order and make-to-stock settings. We show that the HZP outperforms other policies within its class in both cases, a fact that is mainly attributed to its priority-based decisions. When compared to the approximate optimal cost of the problem, our policy performs very well in the make-to-order case, while the simplicity of its base stock structure makes it less competitive in the deterministic make-to-stock problem. The results are then leveraged for the study of a stochastic model, where we consider the effect of random disruptions in the form of machine failures. We prove that our model converges to a fluid limit under an appropriate scaling. This fact allows us to employ our deterministic stability conditions to verify the stochastic (rate) stability of the failure-prone system. We also extend our previous numerical experiments by characterizing the performance of the policies in the stochastic setting. The results show that the HZP still outperforms other policies in the same class. Furthermore, we find that except for cases where failures occur much less or much more frequently than changeovers, the HZP outperforms a fixed-sequence policy that is designed to track a pre-determined, near-optimal deterministic schedule.
by Fernando Tubilla.
Ph.D.
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REGINA, CARLA. « Setdb1 : a novel interactor of ΔNp63α, involved in breast tumorigenesis ». Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/203104.
Texte intégralRésumé :
ΔNp63α è un fattore trascrizionale ampiamente studiato nel cancro alla mammella. Studi recenti indicano che esso è implicato nella tumorigenesi e nell’auto-rinnovamento delle cellule staminali di suddetto cancro. Anche se il profilo trascrizionale di p63 è stato ampiamente caratterizzato, la nostra conoscenza sui suoi possibili interattori implicati nella regolazione del cancro alla mammella è limitata. In questo lavoro abbiamo inizialmente effettuato un saggio di doppio ibrido per cercare dei putativi interattori della proteina che potessero avere un ruolo nella tumorigenicità del cancro al seno. Fra questi, abbiamo identificato Setdb1, una istone lisina metiltrasferasi, che interagisce specificamente con l’isoforma alfa troncata della proteina, ΔNp63α, interazione che contribuisce alla stabilità di p63. Setdb1 risulta essere amplificato nei tumori primari della mammella e la sua assenza rende le cellule tumorali meno prone alla crescita. Abbiamo inoltre trovato trenta geni che risultano aumentare dopo il silenziamento di Setdb1 o p63 (quindi geni che sono repressi da entrambe le proteine) e l’espressione di quattro di essi risulta essere positivamente correlata alla sopravvivenza dei pazienti di cancro al seno. Questi risultati suggeriscono che p63 e Setdb1 potrebbero agire come oncogeni in questo tipo di cancro andando a reprimere dei geni che si comportano da soppressori dei tumori.ΔNp63α has been widely studied in breast cancer, and recent studies indicate that it is involved in both breast tumorigenesis and self-renewal potential of breast cancer stem cells. Although the p63 transcriptional profile has been extensively characterized, our knowledge about p63 binding partners, potentially involved in the regulation of breast tumor progression, is limited. Here, we performed the yeast-twohybrid approach to identify p63α interactors involved in breast tumorigenesis. We found that Setdb1, a histone lysine methyltransferase, interacts with ΔNp63α and that this interaction contributes to p63 protein stability. Setdb1 is often amplified in primary breast tumours and its depletion confers growth disadvantage to breast cancer cells. Also, we identified a list of thirty genes repressed by ΔNp63 in a Setdb1dependent manner and the expression of four of them is positively correlated to survival of breast cancer patients. These results suggest that p63 and Setdb1 may have diagnostic and prognostic potential via the repression of common target genes.
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XU, NUO. « MULTIPLE ATTRIBUTE UTILITY ANALYSIS IN SETUP PLAN EVALUATION ». University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069776252.
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Heron, Matthew Joseph. « Assessment of time-dependent capacity of driven piles in Ohio soils ». University of Dayton / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1556303954380124.
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Sveinsson, Ólafur Björgvin. « Measurement setup for High Power Impulse Magnetron Sputtering ». Thesis, Uppsala universitet, Signaler och System, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-162988.
Texte intégralRésumé :
Recently material physics group at Science Institute of University of Iceland has been using reactive sputtering to grow thin films used in various research projects at the institute. These films have been grown using dc sputtering which has been proven a very successful method. High power impulse magnetron sputtering or HiPIMS is an new pulsed power sputtering method where shorter but high power pulses are used to sputter over lower steady power. The project resulted in a functional system capable of growing thin films using HiPIMS. Thin films grown with high power pulses have a higher film density and other more preferable properties compared to films grown using direct current magnetron sputtering.